Penyakit Kulit Alergi

Allergic Reactions

• Immune system naturally responds to foreign substances in body

• Allergic reaction: exaggerated response to foreign substance

• Allergen: substance causing exaggerated effect

Classification of Immunologic Reactions (Gel and Coombs)

Hypersensitivity Reactions

Atopy

• Atopy is the term for the genetic trait to have a predisposition for localized anaphylaxis.

• Atopic individuals have higher levels of IgE and eosinophils.

Urticaria

Wheal and flare pale centers surrounded by rings of

erythemamore uniformly pink in color Itching resolve completely within 24 hours

Urticaria

Mast cell degranulation physical factors Medications Infections Foods

Urticaria

Treatment Eliminating non-sedating anti-histamines sedating anti-histamines Corticosteroid

Signs and Symptoms: Hives

Urticaria - dermatographism

Type 1 – prick tests immediate

Atopic dermatitis

a chronic, relapsing skin disorder that often begins in childhood, improves with age, but often manifests itself in adulthood with a relapsing course.

Atopic dermatitis

Acute lesion: pruritic, erythematous macules or papules

excoriated papules with crust and serum exudates

Diagnosis

Atopic dermatitis

Treatment relief of pruritus restoration of the barrier function of skin elimination of environmental factors that

exacerbate AD amelioration of the inflammation

Food Hypersensitivity

Contact Dermatitis

• eczematous rash site of contact• any site affected, hands and face • allergic; type IV cell-mediated hypersensitivity reaction

following sensitisation eg; cosmetics, nickel,