Declaration: per piece % RDA*Magnesium 23,8 mg 6,3%Vitamin D 1.66 µg 33,3%Calcium Phosphate 30 mg 3,75%Fluoride 0,12 mg 3,4%

* % of Recommended Daily AllowanceRecommeded Daily intake: 5 pieces per day.

Nutrition information per 100 g: Energy 145 kJ/640 kcal Protein 0 g, Carbohydrate 60 g, of which: Sugars 0 g, Polyols 60 g, Fat 0 g, of which: Saturates 0 g, Fibre 0 g, Sodium 0.01 g. Energy per tablet: 2,47 kJ/ 10.88 kcal

Ingredients: Sweetener (xylitol 40%), gum base, sweetener (sorbitol), bulking agent (dicalcium phosphate 1.8%), mineral (magnesium oxide 1.4%), fla-vourings, stabiliser (sodium carboxy methyl cellulose), colours (E171, E133, E132), bulking agent (calcium carbonate 0.33%), sweeteners (sucralose, steviol glycosides), mineral (sodium flouride), antioxidant (E321), vitamin (Vitamin D).

CavityGumThe Gum CavityGum is a chewing gum concept targeting dental health that includes several active ingredi-ents: Magnesium, Vitamin D, Calcium and Fluoride. The gum is available in a Freshmint flavor and it is sweetened with Stevia (no Aspartame).

Bi-Layered Compressed GumFor CavityGum, Fertin’s patented Bi-layered com- pressed chewing gum technology has been utilized. This innovative chewing gum technology is well suit-ed for the inclusion of active ingredients due to a dry and cool manufacturing process, which is ideal for sensitive ingredients. Furthermore, the powder base of the gum ensures an efficient release of the active substances.

Chewing gum and Dental Health For many years, the positive oral benefits of sugar-free chewing gum have been well known1. Plaque removal2, saliva flow3, caries protection4 and re-mineralization5 are known benefits of chewing gum by itself. Besides this, chewing gum also releases actives in the oral cavity, an ideal feature for con-cepts targeting the mouth and teeth.

CavityGum BenefitsBeyond the inherent oral care benefits found with chewing gum, this delivery form also allows a local release of actives into the oral cavity, which is ideal for active ingredients targeting dental health. Con-cerning the active ingredients, Fluoride has been chosen due to its well-known association with cavi-ty protection6. Magnesium has been included, as it has been shown to aid in preventing tooth loss and periodontal disease7,8. Calcium and Vitamin D are fundamental and well-known components for the maintenance of strong bones and teeth9,10. Together with chewing gum, these active ingredients com-prise a dental chewing gum concept designed to protect against cavities and to maintain strong teeth.

SafetyCavityGum is safe for human use. All raw materials are permitted and approved as food ingredients or food additives according to the Danish EU legisla-tion on food.

Product info

References1. Mehta F. (2010): Chewing Gum as a drug delivery system. Archives of Applied Science Research, 2010, 2 (2): 79-99 2. Addy M, Per-riam E, Sterry A (1982) Effects of sugared and sugar-free chewing gum on the accumulation of plaque and debris on the teeth. J Clin Periodontol 9: 346-54 3. Dawes C, Macpherson LMD (1992) Effects of nine different chewing gums and lozenges on salivary flow rate and pH. Caries Res. 26: 176-182 4. Dawes C., MacPherson L. M. The distribution of saliva and sucrose around the mouth during the use of chewing gum and the implications for the site-specificity of caries and calculus deposition. J. Dent. Res. 1993; 72(5): 852-857. 5. Man-ning, R., H. (1992): Effects of chewing gums sweetened with sorbitol or a sorbitol/xylitol mixture on the remineralisation of human enamel lesions in situ. Caries Res. 1992;26(2):104-9. 6. Lamb, W.J., Corpron, R.E., More, F.G., Beltran, E.D., D.S. Strachan, Kowalski, C.J. in situ remineralisation of subsurface enamel lesion after the use of a fluoride chewing gum. 1993;27:111-116 7. Tanaka, K. (2006): Magnesium intake is inversely associated with the prevalence of tooth loss in Japanese pregnant women: the Osaka Maternal and Child Health Study. Magnes Res. 2006 Dec;19(4):268-75. 8. Meisel, P. (2005): Magnesium deficiency is associated with periodontal disease. J Dent Res. 2005 Oct;84(10):937-41. 9. Krall, E. A. (2001): Calcium and vitamin D supplements reduce tooth loss in the elderly. Am J Med. 2001 Oct 15;111(6):452-6. 10. Di Danielle, N. (2004): Effect of supplementation of calcium and vitamin D on bone mineral density and bone mineral

content in peri- and post-menopause women; a double-blind, randomized, controlled trial. Pharmacol Res. 2004 Dec;50(6):637-41.

Fact sheet

Declaration: Per. piece % RDA*Calcium Carbonate 40 mg N/APotassium Glyconate 44 mg N/ADicalcium Diphosph. 30 mg N/AFluoride 0,12 mg 3,4%

* % of Recommended Daily Allowance Recommeded Daily intake: 5 pieces per day.

Nutrition information per 100 g (50 tablets): Energy 584 kJ/140 kcal Protein 0 g, Carbohydrate 58 g, of which: Sugars 0 g, Polyols 58 g, Fat 0 g, of which: Saturates 0 g, Fibre 0 g, Sodium 0 g. Energy per tablet: 11.68 kJ/ 2.80 kcal

Ingredients: Gum base, Sweetener (xylitol 31%, isomalt), bulking agents (calcium carbonate 2.36%, potas-sium glyconate 2.59%, dicalcium diphosphate 1.77%), flavourings, stabiliser (sodium carboxy methyl cellulose), colours (E171, E101, E133), sweeteners (steviol glycosides, sucralose), min-eral (sodium flouride), antioxidant (E321).

SensitiveGumThe Gum Fertin has formulated SensitiveGum with Potas-sium, Calcium and Fluoride, which are all ingredi-ents with proven oral care benefits1,2,3,4, especially for hypersensitivity. The gum has been developed with a spearmint flavor, and it is sweetened with Xylitol and Stevia (no Aspartame).

Bi-Layered Compressed GumFor SensitiveGum, Fertin’s patented Bi-layered compressed chewing gum technology has been utilized. This innovative chewing gum technology is well suited for the inclusion of active ingredients due to a dry and cool manufacturing process, which is ideal for sensitive ingredients. Furthermore, the powder base of the gum ensures an efficient re-lease of the active substances.

Chewing gum and Dental Health For many years, the positive oral benefits of sugar-free chewing gum have been well known5. Plaque removal6, saliva flow7, caries protection8 and re-mineralization9 are known benefits of chewing gum by itself. Moreover, chewing gum also releases ac-tives in the oral cavity, an ideal feature for concepts targeting the mouth and teeth.

SensitiveGum BenefitsPotassium has been used in toothpaste for decades and studies have indicated that its’ ions depolarize the nerve endings of the teeth, inhibiting hypersen-sitivity1,2,3. Fluoride is added to SensitiveGum as a base ingredient for overall protection against cavi-ties4. The combination of the active ingredient bene- fits, and the inherent benefits of gum, make this a useful aid in managing dentin hypersensitivity. When looking at the growth in number of product launches for products targeting dentin hypersensi-tivity10, Fertin is convinced that this product comes with a sizeable market potential.

SafetySensitiveGum is safe for human use. All raw materi-als are permitted and approved as food ingredients or food additives according to the Danish and EU legislation on food.

Product info

References1. Orchardson R, Gillam DG (2000): The efficacy of potassium salts as agents for treating dentin hypersensitivity. J Orofac Pain. 2000 Winter;14(1):9-19. 2. Poulsen, S. et al (2001): Potassium nitrate toothpaste for dentine hypersensitivity. Cochrane Database Syst Rev. 2001;(2):CD001476. 3. Wara-aswapati, N. et al (2005): The effect of a new toothpaste containing potassium nitrate and triclosan on gingival health, plaque formation and dentine hypersensitivity. J Clin Periodontol. 2005 Jan;32(1):53-8. 4. Lamb, W.J., Corpron, R.E., More, F.G., Beltran, E.D., D.S. Strachan, Kowalski, C.J. in situ remineralisation of subsurface enamel lesion after the use of a fluoride chewing gum. 1993;27:111-116 5. Mehta F. (2010): Chewing Gum as a drug delivery system. Archives of Applied Science Research, 2010, 2 (2): 79-99 6. Addy M, Perriam E, Sterry A (1982) Effects of sugared and sugar-free chewing gum on the accumulation of plaque and debris on the teeth. J Clin Periodontol 9: 346-54 7. Dawes C, Macpherson LMD (1992) Effects of nine different chewing gums and lozenges on salivary flow rate and pH. Caries Res. 26: 176-182 8. Dawes C., MacPherson L. M. The distribution of saliva and sucrose around the mouth during the use of chewing gum and the implications for the site-specificity of caries and calculus deposition. J. Dent. Res. 1993; 72(5): 852-857. 9. Manning, R., H. (1992): Effects of chewing gums sweetened with sorbitol or a sorbitol/xylitol mixture on the

remineralisation of human enamel lesions in situ. Caries Res. 1992;26(2):104-9. 10. Mintel GNPD database

Fact sheet

GumThe Gum WhiteGum is a chewing gum that is meant to aid in maintaining a healthy oral hygiene, with a specific focus on teeth whitening. The product comes in a Whitemint flavor and is sweetened with Xylitol and Stevia (no Aspartame)

Bi-Layered Compressed GumFor WhiteGum, Fertin’s patented Bi-layered com- pressed chewing gum technology has been utilized. This innovative chewing gum technology is well sui-ted for the inclusion of active ingredients due to a dry and cool manufacturing process, which is ideal for sensitive ingredients. Furthermore, the powder base of the gum ensures an efficient release of the active substances.

Chewing gum and Dental Health For many years, the positive oral benefits of sugar-free chewing gum have been well known2. Plaque removal3, saliva flow4, caries protection5 and re-mineralization6 are known and documented bene-fits of chewing gum by itself.

WhiteGum BenefitsBy adding active ingredients with oral care bene-fits1,7,9,10, such as Calcium Pyrophosphate, Calcium Carbonate, Sodium Bicarbonate (baking soda) and Fluoride, the inherent benefits of chewing gum are complemented by the effects of the active ingredi-ents. In addition, the local delivery in the oral cavity achieved by chewing gum is very beneficial. Calci-um Pyrophosphate, Calcium Carbonate and Baking Soda have been selected based on the document-ed whitening effects1,9,10. The inclusion of Fluoride is meant to be supportive, by targeting cavity pro-tection7, and thereby creating a well-rounded con-cept for general oral care protection, specifically focused on whitening. Further to the actual product benefits, WhiteGum will cater to a very strong and growing whitening and fluoride market8.

SafetyWhiteGum is safe for human use. All raw materials are permitted and approved as food ingredients or food additives according to the Danish and EU leg-islation on food.

Product info

References1. Kleber C.J. et al (2002): In vitro stain removal/ inhibition and polish by calcium carbonate chewing gums. Poster session Friday March 8th, 2002, Oral Healt Research Program. 2. Mehta F. (2010): Chewing Gum as a drug delivery system. Archives of Applied Science Re-search, 2010, 2 (2): 79-99 3. Addy M, Perriam E, Sterry A (1982) Effects of sugared and sugar-free chewing gum on the accumulation of plaque and debris on the teeth. J Clin Periodontol 9: 346-54 4. Dawes C, Macpherson LMD (1992) Effects of nine different chewing gums and lozenges on salivary flow rate and pH. Caries Res. 26: 176-182 5. Dawes C., MacPherson L. M. The distribution of saliva and sucrose around the mouth during the use of chewing gum and the implications for the site-specificity of caries and calculus deposi-tion. J. Dent. Res. 1993; 72(5): 852-857. 6. Creanor S. L., Strang R., Gilmour W. H., Foye R. H., Brown J., Geddes D. A. M. The effect of chewing gum use on in situ enamel lesion remineralization. J. Dent. Res. 1992; 71:1895-1900. 7. Lamb, W.J., Corpron, R.E., More, F.G., Beltran, E.D., D.S. Strachan, Kowalski, C.J. in situ remineralisation of subsurface enamel lesion after the use of a fluoride chewing gum. 1993;27:111-116 8. $1.6 billion dental hygiene market fueled by teeth whitening and digital cavity detection. by Drew Gutschmidt, iData Research. Dental Tribune, Business USA. September 9, 2011. 9. Ghassemi, A. et al (2012): Effectiveness of a new dentifrice with baking soda and peroxide in removing extrinsic stain and whitening teeth. J Clin Dent. 2012;23(3):86-91. 10. Koertge, T., E., (1998): A longitudinal

comparison of tooth whitening resulting from dentifrice use. J Clin Dent. 1998;9(3):67-71.

Fact sheet Declaration: per piece % RDA*Calcium Pyr.Phosph. 100 mg N/ACalcium Carbonate 48 mg N/ABaking Soda 5 mg N/AFluoride 0,12 mg 3,4%

* % of Recommended Daily AllowanceRecommeded Daily intake: 5 pieces per day.

Nutrition information per 100 g: Energy 132 kJ/548 kcal Protein 0 g, Carbohydrate 55 g, of which: Sugars 0 g, Polyols 55 g, Fat 0 g, of which: Saturates 0 g, Fibre 0 g, Sodium 0,1 g. Energy per tablet: 2,24 kJ/ 9,32 kcal

Ingredients: Sweetener (xylitol 34%), gum base, sweet-ener (sorbitol), bulking agents (dicalcium di-phosphate 5.9%, calcium carbonate 2.8%), flavourings, stabiliser (sodium carboxy me-thyl cellulose), colour (E171), acidity regu-lator (sodium hydrogen carbonate 0.29%), sweeteners (sucralose, steviol glycosides), mineral (sodium flouride), antioxidant (E321).