Medical Sc ient ist Tra in ing Program

Lila Gollogly Glotfelty BA, Biology, Harvard College, 2004; PhD, Dept of Microbiology & Immunology; Advisor: Gail Hecht, MD PhD Thesis: “Enteropathogenic E. coli EspG1/G2 Perturb Microtubules and Im-pede Tight Junction Regulation and Recovery” Residency: Internal Medicine, UIC Ina Han Lee BS, Molecular Cell Biology, UC-Berkeley, 1999 MS, Biotechnology, Johns Hopkins University, 2005 PhD, Program in Neuroscience; Advisor: Scott Brady, PhD PhD Thesis: “The Role of c-Jun N-Terminus Kinase Isoforms in Huntington’s Dis-ease Pathogenesis“ Residency: Pathology: University of Maryland Medical Center

Vanessa Reese McFadden BA, Community Health, Brown University, 2006 PhD, Dept of Microbiology & Immunology; Advisor: Alan McLachlan, PhD PhD Thesis: “Transcriptional Regulation of Hepatitis B Virus Biosynthesis by Bile Acids and FoxA Factors” Residency: Pediatrics, Medical College of Wisconsin, Milwaukee

Sachin Moonat BA, Molecular Biology, UC Berkeley, 2002 MA, Physiology, UC Berkeley, 2005 PhD, Program in Neuroscience; Advisor: Subash Pandey, PhD PhD Thesis: “The role of amygdaloid chromatin and synaptic remodeling in anxiety and alcoholism“ Post Graduate Research Position: TBA Lawren VandeVrede BS, Biology & Chemistry, Florida State University, 2007 PhD, Program in Neuroscience; Advisor: Gregory Thatcher, PhD PhD Thesis: “Nitrate Chimeras: A New Class of Disease-Modifying Agents for the Treatment of Alzheimer’s Disease” Residency: Internal Medicine, Massachusetts Gen. Hospital; Neurology, Brig-ham & Women’s Hospital, Boston. Jonathan Waxman BS, Computer Science, University of Pennsylvania, 1998 PhD, Dept. of Electrical & Computer Engineering; Advisors: David Carley, PhD; Daniel Graupe, PhD PhD Thesis: “Prediction of Pathophysiological Events: Sleep Disordered Breathing, Vigilance Lapses, and Driving Mistakes” Residency: Otolaryngology, Wayne State University School of Medicine, Detroit, MI

Volume 15, Issue 2

CONGRATULATIONS 2014 GRADUATES

Apri l 30 , 2014

Calendar: Thursday, May 8, 5:30PM, Graduation Banquet, La Luce Restaurant Friday, May 9, 2:00 pm COM Graduation, UIC Pavilion Tuesday, May 20, 5:30 pm Dinner Seminar Gail Prins, PhD

I N S I D E T H I S I S S U E :

Awards, Honors, etc. 2

Alumni News 3

Wedding Bells 3

Recent Student Publications 4

2013 Grand Rounds 5

Graduation Banquet 6

Dinner Seminars 6

MEDICAL SCIENTIST

SAVE THE DATE

JUNE 22-23, 2014

MSTP RETREAT

Starved Rock

State Park

Bus transporta-tion to and fro will

be provided.

Details to follow in

separate bulletin.

Ryan Lahey, G4, was one of three finalists for the 2013 CCVR Young Investigator Research Awards, as announced by E. Douglas Lewandowski, PhD, Director of the Center for Cardiovascular Research and Professor in the Departments of Physiology & Biophysics and Medicine (Cardiology). The three finalists presented their work as oral abstract presenta-tions during the CCVR research day activities on Tuesday September 10, 2013 and were selected by a panel of CCVR faculty from the abstract submissions for the CCVR Research Day. Ryan’s presentation, entitled: “Lipid dynamics in de-compensated hearts are influenced by chain composition of major dietary fats and linked to nuclear signaling through peroxisome proliferator-activated receptor-alpha”, won first prize.

Mir (Isaam) Isaamullah, M1, was elected Historian in the September 2013 elections for the M1 Class Board.

On September 13, 2013, the Office of Student Affairs announced the members of the Class of 2014 that were inducted into the COM chapter of the Alpha Omega Alpha Medical Honor Society, including two MSTP students, Sachin Moonat, M4 and Lawren (Ren) VandeVrede, M4. AOA was founded in 1902 by William Webster Root and five other medical students at the College of Physicians and Surgeons, which eleven years later became the U of I COM. AOA is organized for educational purposes exclusively and not for profit, and its aims shall be the promotion of scholarship and research in medical schools, the encouragement of a high standard of character and conduct among medical students and gradu-ates, and the recognition of high attainment in medical science, practice, and related fields.

At the Department of Physiology & Biophysics 24th Annual Awards/Recognition Evening on November 20, 2013, the fol-

lowing awards were given to MD-PhD students: 2013 Kate Barany Graduate Student Award – Sarah Baumgarten, G3 2013 Mark R. Lambrecht Award for Scholarship and Commitment: Ryan Lahey, G4

On November 26, 2013, Michael Cho, PhD, Professor in the Department of Bioengineering and Thesis Advisor to Farah Shareef, G3, proudly informed us that Farah was a winner of the 2013 Chancellor's Graduate Research Fellowship.

Dr. Tobacman, wearing his hat as Senior Associate Dean of Research, had the pleasure of announcing the 2013 COM Research Forum Award winners, including these MD-PhD students: Honorable Mention to Ryan Lahey, G4 (Physiology and Biophysics), Michael Marshall, G1 (Anatomy and Cell Biology), Christine Haddad, G3 (Microbiology and Immunol-ogy), and Justin Sysol, G1 (Medicine).

On December 5, Alicia Rizzo proudly reported that her American Heart Association grant application was awarded with a fellowship.

The FMC Technologies, Inc, Educational Fund Selections Committee selected Farah Shareef on March 25 as the win-ner of their 2014-15 Fellowship Award. This award was established in 1963 by a generous donation to the U. of I. Foun-dation by 1897 alumnus Bert A. Gayman.

Page 2

Awards, Honors, Presentations – Congratulations!

Volume 15, Issue 2

On Sunday, October 13, 2013, Christine Haddad, G3, ran the Chicago Marathon with a time of 3:49:23 as part of Cellmates on the Run of the Chicago Diabetes Projects, which raises funds for dia-

betes research. Prior to the run she sent out the following message, with a picture of her 2012 Mara-

thon run : Dear friends and family,

Another year, another marathon, and I am again running the Chicago Marathon this year to raise money for the Chicago Diabetes Project. Running for a cause means a lot of me, and your contribu-

tion and support in the past years has made my race experience much more meaningful. Please con-sider supporting me again this year as I do what I can to raise awareness and funds.

GOLDEN APPLE AWARD TO DR. NANCY FREITAG COM Class of 2016 President Karen Tye announced on March 17 that this year's M2 Golden Apple Award recipient is Dr. Nancy Freitag, Associate Di-rector of the MSTP and Associate Professor in the Dept. of Microbiology & Im-munology. Ms Tye expressed appreciation and gratitude on behalf of the en-

tire M2 class for Dr. Freitag’s “wonderful work furthering our medical education this year.” The 2014 COM Golden Apple awards were bestowed at the CMSC general body meeting and dinner on April 21.

Medical Scientist Page 3

Alumni News Wedding

Bells

Congratulations to Vanessa Reese on her marriage to Ben McFadden on November 16, 2013 in Orlando, FL at her aunt's home.

Congratulations to Alan Tseng on his marriage to Cindy Hou, Guest Service Manager, Club Quarters Central Loop on De-cember 28, 2013 at Shangri-La's Far Eastern Plaza Hotel, Taipei, Taiwan. Aside from family, they had friends from the US, Taiwan, HK, Shanghai, Japan, and Europe celebrate with them.

Again we are deeply grateful to Tatiana Grzeszkiewicz, 2003, for her second generous donation to the program. This donation, in De-cember 2013, came earmarked "for something social for the students!" The Student Activities has been apprised of this wonderful news and is thinking of ways to use it to the best advan-tage of all. (At right is Dr. G’s annual Christmas photo of her family).

In the Alumni Mailbag

From: Rahul Davé (2010) [mailto:rahulhdave@gmail.com]

Sent: Monday, March 10, 2014 9:30 PM

To: Bernstein, Roberta

Dear Roberta, How are you?

I am finishing my Neurology residency in Miami, and have accepted a position at the NIH

in Bethesda, Maryland for a combined clinical-basic research fellowship in Neuroinflamma-

tory diseases.

If any of the current students have questions about Neurology, or Miami's program, feel

free to pass on my contact information.

Sincerely, Rahul

Note to all alumni: Please keep the updates on your news coming. And if you’re going to be in Chicago, please stop by for a visit which can be informal or a formal presenta-

tion, as you wish.

Congratulations to Ike Madueke on his engage-ment to and Ijeoma Oke-chukwu, an M3 at U. MN SOM.

Welcome Home to UIC In autumn semester 2013, UIC welcomed back Kharma Foucher (2005) as Assistant Professor in the Dept. of Kinesiology and Nutrition and Adjunct Assistant Professor in the Dept. of Bioen-ginneering (where she earned he UIC PhD). She was formerly Assistant Professor of Orthopedic Surgery at Rush University Medi-

cal Center, Dept. of Orthopedics.

Condolences to Roy Smetana, 2009, and his children on the passing of their wife and mother, Mary Lipple.

Edwin deZoeten (2001) sent this lovely

photo of himself with his family, Xander

(7mo), Laina (7), wife Karen, Ana(10),

Cole (9 ), in October 2013 prior to his

informal talk October10 to current stu-

dents during a quick visit to Chicago. Dr.

deZoeten is an Assistant Professor of

Pediatrics-Gastronenterology at the

Univ. of Colorado SOM and Scientific

Director of the Pediatric IBD Center,

Children’s Hospital, Colorado Digestive

The wedding is planned for May 31, 2014.

Page 4 Volume 15, Issue 2

Recent Student Publications – as of March 2014

Joseph Bogaard, G3 Chang Q, Berdyshev E, Bogaard JD, White JJ, Chen S, Shah R, et al. Cytochrome P450 2C Epoxygenases Mediate Photochemical Stress-induced Death of Photoreceptors. Journal of Biological Chemistry. 2014. doi: 10.1074/jbc.M113.507152.

Grassi MA, Rao V, Winkler KP, Zhang W, Bogaard JD, Chen S, et al. Genetic variation is the major determinant of indi-vidual differences in leukocyte endothelial adhesion. PloS one. 2014;9(2):e87883. Epub 2014/02/13. doi: 10.1371/journal.pone.0087883. PubMed PMID: 24520339; PubMed Central PMCID: PMCPMC3919726.

Jason Buhrman, G3 Wei Zhang, Giulia Fulci, Hiroaki Wakimoto, Tooba A. Cheema, Jason S. Buhrman, Deva S. Jeyaretna, Anat O. Stem-mer Rachamimov, Samuel D. Rabkin, Robert L. Martuza. Combination of Oncolytic Herpes Simplex Viruses Armed with Angiostatin and IL12 Enhances Anti-tumor Efficacy in Human Glioblastoma Models. Neoplasia. 2013, 15(6).

Köllmer M, Buhrman JS, Zhang Y, Gemeinhart RA. Markers Are Shared Between Adipogenic and Osteogenic Differen-tiated Mesenchymal Stem Cells. Journal of Developmental Biology and Tissue Engineering 5(2): 18-25, 2013

Jason S. Buhrman, Laura C. Cook, Jamie E. Rayahin, Michael J. Federle, Richard A. Gemeinhart. Proteolytic activated anti-bacterial hydrogels. Journal of Controlled Release. 171 (3) 288-295. 2013

Jason S. Buhrman, Laura C. Cook, Jamie E. Rayahin, Michael J. Federle, Richard A. Gemeinhart. Active, soluble re-combinant melittin purified by extracting insoluble lysate of Escherichia Coli without denaturation. Biotechnology Pro-gress. 29 (5) 1150-1157. 2013.

Michael Fettiplace, G2 Fettiplace, M. R., Akpa, B., Ripper, R., Zider, B., Lang, J., Rubinstein, I., & Weinberg, G. (2014). Resuscitation with Lipid Emulsion : Dose-dependent Recovery from Cardiac Pharmacotoxicity Requires a Cardiotonic Effect. Anesthesiology, 120(4), 915–925.

Fettiplace, M. R., Ripper, R., Lis, K., Feinstein, D. L., Rubinstein, I., & Weinberg, G. (2014). Intraosseous Lipid Emul-sion: An Effective Alternative to IV Delivery in Emergency Situations. Crit Care Med, 42(2), e157–160.

Fettiplace, M. R., Ripper, R., Lis, K., Lin, B., Lang, J., Zider, B., … Weinberg, G. (2013). Rapid Cardiotonic Effects of Lipid Emulsion Infusion. Crit Care Med, 41(8), e156–e162.

Fettiplace, M. R., & Weinberg, G. (2013). Should transient physiologic effects following lipid administration be attributed to a cellular signaling mechanism without cellular data? Crit Care Med, 41(11), Author reply. Krishnamoorthy, V., Vavilala, M., Fettiplace, M. R., & Weinberg, G. (2014). Epinephrine for Cardiac Arrest: Are We Do-ing More Harm Than Good? Anesthesiology, 120(4), 792–794.

Alan Perez-Rathke, M2 1/3/2013, Perez-Rathke A, Li H, Lussier YA. Interpreting personal transcriptomes: personalized mechanism-scale profil-ing of RNA-seq data. Pac Symp Biocomput. 2013:159-70. PMID: 23424121.

Alicia Rizzo, G2 Rizzo AN, Fraidenburg DR, Yuan JX. Pulmonary Vascular Anatomy, in Lanzer P, ed. PanVascular Medicine 2nd Edition: New York, NY, Springer, 2014 (In Production). Rizzo AN, Fraidenburg DR, Yuan JX. Pulmonary Vascular Physiology and Pathophysiology, in Lanzer P, ed. PanVascu-lar Medicine 2nd Edition: New York, NY, Springer, 2014 (In Production).

Goldman J, Sammani S, Kempf C, Saadat L, Letsiou E, Wang T, Moreno-Vinasco L, Rizzo AN, Fortman J, Garcia JGN. Pleiotropic effects of interleukin 6 in a “two hit” murine model of acute respiratory distress syndrome. (Accepted). Pulmo-nary Circulation, 2014. Frencher JT, Shen, H, Yan L, Rizzo AN, Wilson, JO, Freitag NE, Shen L, Chen ZW. Infection with HMBPP-deficient IPP-producing Listeria mutant alters pulmonary and systemic immune responses, effector functions, and memory polarization of Vγ2Vδ2 T cells. (Accepted) Journal of Leukocyte Biology. January 2014.

Medical Scientist Page 5

Chen W, Sharma R, Rizzo AN, Siegler JH, Garica JG, Jacobson JR. Role of Claudin-5 in the Attenuation of Murine Acute Lung Injury by Simvastatin. Am J Respir Cell Mol Biol. 2013 Sep 12. PubMed PMID: 24028293. Xiao H, Rizzo AN, Siegler J, Chen W. The Importance of Bronchial Epithelial Junction Integrity in Asthma. J Allergy Therapy S11:003. doi: 10.4172/2155-6121.S11-003, 2013.

Matthew Tobin, G1

9/23/13, Alaraj A, Tobin M, Birk D, Aletich V. Role of argatroban during neurointerventional procedures in patients with heparin induced thrombocytopenia. J Neurointerv Surg. 2013. [Epub ahead of print]

12/10/2013, Tobin MK, Birk D, Siemionow K, Neckrysh S, Schizas C. T1 pedicle subtraction osteotomy for the treatment of rigid cervical kyphotic deformity: Clinical series of four patients and review of the literature. J Neurosurg Spine. 2013. In press.

8/10/2013, Book chapter: Birk DM, Tobin MK, Slavin KV: Neurosurgical options for control of chronic and malignant ab-dominal pain, in Kapural L (ed): Visceral Abdominal pain: An Evidence-Based, Comprehensive Guide to Clinical Manag-ment. Springer-Verlag, 2013, accepted

Jonathan Waxman, M4

4/1/2014, Waxman J, Carley DW, Graupe D. Automated Prediction of Apnea and Hypopnea Using a LAMSTAR Artificial Neural Network. American Journal of Respiratory and Critical Care Medicine. 2010 Apr; 181(7): 727-33. Cited in Pub-Med; PMID: 20019342.

2014 Student Grand Round Presentations Tuesday, February 18, 12:30 pm, 5175 COMRB - In conjunction with the CCTS Topic: "Acute Respiratory Distress Syndrome: Current Approaches and Future Directions" Clinical Presentation: Lila Gollogly Glotfelty M4, defended doctoral thesis August 17, 2012 in the Dept. of Microbiology & Immunology on ““Enteropathogenic E. coli EspG1/G2 Perturb Microtubules and Impede Tight Junction Regulation and Recovery” (advisor: Gail Hecht, MD) Research Presentation: P. David McMullen and Alicia Rizzo McMullen-4th year graduate student, Dept. of Microbiology & Immunology (advisor: Nancy Freitag, PhD) Rizzo-2

nd year graduate student, Dept. of Pharmacology (advisor: Steven Dudek, MD)

Presentation Faculty Advisors: Steven Dudek, MD, and Patrick Belvitch, MD, Dept. of Medicine: Pulmonary, Critical Care, Sleep & Allergy

Tuesday, March 11, 12:30 pm, 5175 COMRB - In conjunction with the CCTS Topic: “Secondary neoplasms in childhood cancer survivors” Clinical Presentation: Vanessa Reese McFadden M4, defended doctoral thesis on April 17, 2012 in the Dept. of Microbiology & Immunology on “Transcriptional Regulation of Hepatitis B Virus Biosynthesis by Bile Acids and FoxA Factor” (advisor: Alan McLachlan, PhD) Research Presentation: Ryan Carr M3, defended doctoral thesis on May 24, 2013 in the Dept. of Microbiology & Immunology on “Utilizing the Warburg Ef-fect to Enhance TRAIL-Induced Apoptosis in Several Cancer Types” (advisor: Bellur Prabhakar, PhD) Presentation Faculty Advisor: Mary Lou Schmidt, MD. Associate Professor, Dept. of Pediatrics

Tuesday, April 8, 12:30 pm, 5175 COMRB - In conjunction with the CCTS Topic: “Immunomodulatory therapies in type 1 diabetes” Clinical Presentation: Ina Han Lee M4, defended doctoral thesis on September 4, 2012 in the Neuroscience Program on “The Role of c-Jun N-Terminus Kinase Isoforms in Huntington’s Disease Pathogenesis” (advisor: Scott Brady, PhD) Research Presentation: Christine Haddad 3rd year graduate student, Dept. of Microbiology & Immunology (advisor: Bellur Prabhakar, PhD) Presentation Faculty Advisor: Bellur Prabhakar, PhD

COMING: Thursday, June 2—Topic and time TBA Clinical Presentation: Jonathan Waxman, M4 Research Presentation: Jason Buhrman, G3

University of Illinois

College of Medicine

COM Dean’s Office, MC 784

1853 West Polk Street

Chicago, IL 60612

Medical Scient is t Training Program

Phone: 312-996-7473

Fax: 312-413-8221

E-mail: roberta@uic.edu

MSTP Administration Larry S. Tobacman, MD Director Nancy Freitag, PhD Associate Director Roberta Bernstein, Assistant Director Medical Scientist Editor

COM Administration Dimitri Azar, MD, Dean Larry S. Tobacman, MD, Sr. Associate Dean for Research Kathleen Kashima, PhD, Interim Senior Assoc. Dean for Education Jorge Girotti, PhD, Associate Dean and Director of Admissions and Special Curricular Programs Kathleen Kashima, PhD, Senior Associate Dean of Students

We’re on the web!

www.uic.edu/com/mdphd

Spring 2014 Dinner Seminars Thursday, April 24, 2014, 6:30 p.m., 120 COMRB Annual Joint Seminar with MSTPs of Northwestern University and University of Chicago Kevin Shannon, MD, American Cancer Society Research Professor and Auerback Distinguished Professor of Mo-lecular Oncology, Department of Pediatrics, UCSF “Physician Scientist Pathways in 2014” Tuesday, May 20 2013, 5:30 p.m., 300 CSN Gail Prins, PhD, Professor of Physiology, Dept. of Urol-ogy “The Endocrine Disruptor Bisphenol A (BPA) Reprograms Human Prostate Stem Cells and Increases Prostate Can-cer Susceptibility ”

The UIC MSTP cordially invites you to its Graduation Seminar and Banquet

Thursday, May 8, 2015 La Luce Restaurant, 1393 W. Lake St. (at Loomis)

5:30 p.m. Reception 6:00 p.m. Seminar 7:00 p.m. Dinner Our Honored Graduates:

Lila Ina Sachin Vanessa Lawren Jonathan Glotfelty Lee Moonat McFadden VandeVrede Waxman

Our Guest Speaker: Uzma Samadani MD, PhD (UIC 1999) Chief Neurosurgeon, New York Harbor Health Care System Co-Director, Steven and Alexndra Cohen Veterans Center for

PTSD and TBI, Assistant Professor, Departments of Neurosurgery, Psychiatry and Physiology & Neuroscience

New York University School of Medicine

“Development of an Eye Tracking Biomarker for Concussion”

RSVP by April 30 to Roberta Bernstein, Roberta@uic.edu

Page 6 Volume 15, Issue 2

Page 7 Medical Scientist