medical scientist training program (mstp) annual report...

Medical Scientist Training Program (MSTP)

Annual Report 2016-2017

College of Graduate StudiesCollege of Medicine

MEDICAL SCIENTIST TRAINING PROGRAM Steering Committee

2016-2017

Dr. Perry V. Halushka Director, MSTP Distinguished University Professor Committee Chair Dr. Nancy DeMore Associate Director, MSTP Professor of Surgery Medical Director, Breast Center BMW Endowed Chair in Cancer Research Ms. Amy Connolly Assistant Director, MSTP Dr. Steven L. Carroll Professor & Chair, Pathology & Laboratory Medicine Dr. Benjamin Clyburn Associate Professor, Medicine Associate Dean for Graduate Medical Education Faculty Development, College of Medicine Dr. Christopher Cowan Associate Professor, Neuroscience Dr. Michael A. de Arellano Senior Associate Dean for Diversity, College of Medicine Director, Mental Health Disparities and Diversity Program Professor of Psychiatry & Behavioral Sciences Dr. Christopher Davies Professor of Biochemistry & Molecular Biology Dr. Scott Eblen Associate Professor of Cell & Molecular Pharmacology Dr. Carol Feghali-Bostwick Kitty Trask Holt Endowed Chair Professor, Rheumatology & Immunology

Dr. Donna Kern Associate Professor, Family Medicine Associate Dean for Curriculum in the Clinical Sciences, College of Medicine Dr. Michael Kern Professor of Regenerative Medicine and Cell Biology Dr. Viswanathan Ramakrishnan Professor, Biostatistics & Epidemiology Dr. Don Rockey Professor and Chair of Medicine Dr. Baerbel Rohrer Professor of Neurosciences Dr. Cynthia Schandl Associate Professor of Pathology & Laboratory Medicine Myra Haney Singleton, M.Ed. Assistant Dean for Student Affairs College of Medicine Dr. Joann Sullivan Assistant Dean for Extramural Program Development Dr. Stephen Tomlinson Professor of Microbiology & Immunology Dr. Graham Warren Associate Professor of Radiation Oncology Dr. Patrick Woster Professor, Interim Chair and SmartState Endowed Chair in Drug Discovery Dr. Michael Yost Associate Professor of Surgery Sagar Bajpai MSTP Student Representative

College of Graduate Studies College of Medicine

MEDICAL SCIENTIST TRAINING PROGRAM COMMITTEES

2016-2017 Progress Committee Dr. Perry Halushka Dr. Robin Muise-Helmericks

Scholarship Committee Dr. Perry Halushka Dr. Robin Muise-Helmericks

Recruitment Committee Dr. Perry Halushka William F. Conway, MD, PhD Melissa Cunningham, MD Scott Eblen, PhD Carol Feghali-Bostwick, PhD Victoria Findlay, PhD Elizabeth Garrett-Mayer, PhD Perry Halushka, PhD, MD Michael Kern, PhD Yiannis Koutalos, PhD Kyo-Ho Lee, PhD Eric Meissner, MD, PhD Robin Muise-Helmericks, PhD Arthur Riegel, PhD Baerbel Rohrer, PhD Steven Rosenzweig, PhD Cynthia Schandl, MD, PhD Juan Varela, MD, PhD Graham Warren, MD, PhD Michael Yost, PhD Dr. Cynthia Wright – Ex-officio Dr. Deborah Deas – Ex-officio Dr. Donna Kern – Ex-officio Ms. Amy Connolly – Ex-officio

Seminar Committee Mr. Jacob Bowers Mr. David Hartmann Representative to Graduate Council Mrs. Katelyn Williams

College of Graduate Studies College of Medicine

MEDICAL SCIENTIST TRAINING PROGRAM STUDENTS

MSTP Matriculation Students Date Advisor Undergraduate School Ali Alawieh 6/13 Dr. S. Tomlinson American University of Beirut Dimitrios Arhontoulis 6/17 Dr. A. Shih Drexel University Sagar Bajpai 6/15 Dr. J.A. Diehl University of Maryland Baltimore County Fahmin Basher 6/08 Dr. J. Wu University of South Carolina Krishna Bharani 6/13 Dr. L. Granholm Loyola University Daniel Bonthius 7/15 Dr. H. Yao Wartburg College Davis Borucki 6/17 Dr. B. Ogretmen Boston University Jacob Bowers 6/11 Dr. C. Paulos University of Utah David Braak 6/16 Dr. M. Commings Temple University Robert Cameron 5/11 Dr. R. Schnellmann Davidson College Ying Chao 8/14 Dr. T. Jhou University of California San Diego Vivian Chioma 6/14 Dr. P. Kalivas University of Maryland Baltimore County Yongjoo Cho 6/16 Dr. C. Cowan Temple University Stewart Cox 7/15 Dr. C. Reichel University of Colorado Boulder Mohammed Dany 6/13 Dr. B. Ogretmen American University of Beirut Danielle Desjardins 6/11 Dr. Z. Ablonczy Boston University Maya Eid 6/15 Dr. T. Jhou American University of Beirut J. Gray Evans 6/16 Dr. A. Shih University of Virginia Stephen Gadomski 7/17 Dr. S. Duncan University of Scranton George Russell Glenn 8/10 Dr. J. Helpern/ Wofford University Dr. J. Jensen Alice Kim 6/16 Dr. C. Paulos Emory University David Hartmann 7/12 Dr. A. Shih New College of Florida Daniel Herr 6/11 Dr. D. Menick University of Scranton Nour Hijazi 6/17 Dr. J. McGinty American University of Beirut Nathaniel Jensen 6/13 Dr. H. Cheung Brigham Young University Hannah Knochelmann 8/15 Dr. C. Paulos Notre Dame Craig Kutz 6/10 Dr. P. Woster Minnesota State University Moorhead Hyunwoo Tony Kwon 8/14 Dr. Z. Li University of Toronto Elizabeth Farris Langley 6/17 Dr. S. Tomlinson College of Charleston Danielle Clark Lowe 6/09 Dr. I. Singh/ Marshall University Dr. D. Jenkins Emilie McKinnon 6/17 Dr. L. Bonihla Ku Leuven University/MUSC Allison Meadows 8/15 NIH University of Virginia Jamie Mills 6/11 Dr. S. Ethier California State University- Chico Christopher Mullins 6/15 Dr. M. George University of North Carolina Chapel Hill Daniel Neitzke 6/10 Dr. D. Cole/ University of Virginia Dr. M. Rubinstein

Ken Noguchi 5/12 Dr. P. Howe Kenyon College Elizabeth Ogunrinde 6/14 Dr. W. Jiang Florida State University Alexander Oles 6/16 Dr. S. Carroll Kenyon College Sanket Pattanaik 6/13 Dr. M. Yost Cornell University Guillermo Rangel Rivera 6/16 Dr. Z. Li University of South Carolina Matthew Roberts 6/16 Dr. T. Naselaris Rhodes College Douglas Roberts-Wolfe 6/11 Dr. P. Kalivas Hampshire College Sarah Brice Russo 6/10 Dr. A. Cowart Clemson University/MUSC Jennifer Scott 8/09 Dr. G. Gilkeson University of Central Florida Mohamad Mahdi Sleiman 6/16 Dr. C. Paulos American University of Beirut Joshua Smith 6/08 Dr. R. Schnellmann Wofford College Victoria Spadafora 6/17 Dr. C. Feghali-Bostwick Pennsylvania State University Park Erik Strungs 6/09 Dr. L. Luttrell University of Minnesota- Twin Cities Catherine Svetcharnik 5/15 Dr. J. McGinty University of Colorado Ralph Tanios 6/15 Dr. S. Carroll American University of Beirut Amer Toutonji 6/16 Dr. S. Tomlinson American University of Beirut Danh Tran 6/13 Dr. S. Nadig University of California- Los Angeles Jonathan Turner 6/13 Dr. C. Davies West Virginia University Shannon Weber 7/15 Dr. S. Carroll University of Richmond Ryan Whitaker 6/08 Dr. R. Schnellmann University of Iowa Melanie Wiley 7/15 Dr. M. George University of Maryland Baltimore County Katelyn Williams 6/12 Dr. S. Olsen University of Maryland Baltimore County Daniel Wood 6/17 Dr. C. Cowan University of South Carolina

Current Positions of MUSC MSTP Graduates (1982-2017)

MSTP Graduate Grad Year

Residency Current Position

Samuel E. Gandy, MD, PhD 1982 Cornell University Professor of Neurology and Psychiatry, Mount Sinai Chair in Alzheimer's Disease Research, Geoffrey E. Renk, MD, PhD 1986 UCLA President, Charleston Emergency Services

R. Paul Aftring, MD, PhD 1987 Beth Israel Senior Global Program Head/Vice President, Established Medicines, Novartis Pharmaceuticals Corporation

Charles F. Burant, MD, PhD 1987 University of California San Francisco

Robert C. and Veronica Atkins Professor of MetabolismProfessor, Internal MedicineProfessor, Molecular & Integrative PhysiologyProfessor, Department of Nutritional Sciences, School of Public HealthProfessor, School of KinesiologyDirector, Michigan Metabolomics and Obesity CenterDirector, Michigan Regional Comprehensive Metabolomics Resource CoreDivision of Metabolism, Endocrinology, and DiabetesUniversity of Michigan Health System

*Kevin D. Ballard, MD, PhD 1989 Baylor College of Medicine

Deceased

Richard L. Griffith, MD, PhD 1989 University of Virginia Hospital

Private Practice, Internal Medicine, Marietta, GA

*Stanley A. Katz, MD, PhD 1989 Vanderbilt University DeceasedMargaret O. Sowell, MD, PhD 1990 Brigham and

Women's HospitalMedical Director, Global Clinical Safety and Pharmco-vigilence, GlaxoSmithKline

Richard H. Peters, MD, PhD 1991 Massachusetts General Hospital

Senior Vice PresidentHead of Global Rare Diseases Franchise and Head of JAPAC Specialty Care Business UnitSanofi Genzyme

N. Carolyn Schanen, MD, PhD 1991 Stanford University Adjunct Associate Professor, Biological Sciences, University of Delaware/Head of Human Genetics Research, A.I. duPont Hospital for Children

Keith A. Coffee, MD, PhD 1992 Vanderbilt University Vice President, Internal Medicine, Scientific Affairs, PRA Health Sciences

Stephen R. Murray, MD, PhD 1992 University of California San Francisco

Senior Medical Officer, Global Alliance for TB Drug Development, New York, NY

Jeffrey L. Twiss, MD, PhD 1992 Stanford University SmartState Endowed Chair in Child Neurotherapeutics, Professor of Biological Sciences, University of South Carolina

William F. Oehlenschlager, MD, PhD 1993 Case Western Reserve University

Clinical Assistant Professor, Pediatrics, Ohio University College of MedicinePrivate Practice, Pediatrics, Wadsworth, OH

Richard C. Ross, MD, PhD 1993 Johns Hopkins University

Emergency Medicine, Modesto, CA

Kendrick A. Shunk, MD, PhD 1993 University of Chicago Professor of Medicine, University of California San FranciscoDirector Cardiac Catheter Lab, San Francisco VA Medical Center

Charles J. Beischel, MD, PhD 1994 Medical University of South Carolina

Assistant Professor, Ophthalmology, MUSC, Ralph H. Johnson VA Medical Center



James Bryan Hill, MD, PhD 1995 Baylor University Assistant Professor of Clinical Pediatrics, USC School of MedicineSpecial Care Pediatric Center, Greenville Health System Children's Hospital, Anderson, SC

Charles T. Ivester, MD, PhD 1996 University of Utah Private Practice, Pulmonary, Critical Care and Sleep Medicine, Ogden, Utah

Timothy C. Ball, MD, PhD 1997 Bowman Gray Assistant Professor of Medicine & Medical Director Cardiac Catheterization Laboratory, Virginia Tech Carilion School of Medicine, Roanoke, VA

Bradley S. Miller, MD, PhD 1997 Mayo Clinic Associate Professor, Pediatrics/Endocrinology, University of Minnesota Masonic Children's Hospital

Kimberly V. Barnes, MD, PhD 1998 University of Chicago Private Practice, Biloxi, MSCharles E. Hill, MD, PhD 1998 Emory University Professor and Vice Chair of Education

Program Director, Pathology ResidencyDepartment of Pathology and Laboratory MedicineEmory University School of MedicineDirector, Molecular Diagnostics LaboratoryEmory University Hospital

Ana Maria Ibrado, MD, PhD, FACEP 1998 Johns Hopkins University

Medical Director, Stroke Center and Clinical Decision Unit, Providence Hospital, Washington, DC

Gloria Bullock Morris, MD, PhD 1998 Thomas Jefferson University

Hematology & Oncology Associates of Central New York, Syracuse, NY

John H. Cleator, MD, PhD 1999 Cleveland Clinic Assistant Professor of Medicine, Cardiology Division, Director of the Experimental Angiographic Laboratory, Director, Interventional Cardiology Research, Vanderbilt University

Michel A. Makhlouf, MD, PhD 1999 University of Pittsburgh Magee Women's Hospital

Senior Attending Physician, OB/Gyn, Sidra Medical and Research Center, Doha, Qatar/Adjunct, Weil Cornell Med College-Qatar

Cynthia A. Schandl, MD, PhD 1999 Medical Univ. of South Carolina

Associate Professor, Pathology and Laboratory Medicine, Medical University of South Carolina

Keith T. Borg, MD, PhD 2000 University of Cincinnati

Associate Professor, Emergency Medicine/, Medical University of South CarolinaMedical Director, Lifenet 7 Moncks Corner, Air Methods Corporation

Justin P. Favaro, MD, PhD 2000 University of Texas, Dallas Southwestern Medical Center

Assistant Consulting Professor, Medicine, Duke University/Private Practice, Hematology/Oncology, Charlotte, NC

Kim M. Huffman, MD, PhD 2000 Duke University Associate ProfessorDivision of Rheumatology and Immunology Department of MedicineMolecular Physiology InstituteDuke University School of MedicineDurham VA Medical Center

Antoine A. Makhlouf, MD, PhD 2000 University of Virginia Private Practice, Urology, Sugar Land, TX



Donald C. Shields, MD, PhD 2000 UCLA Associate Professor, Neurosurgery, George Washington University

Kristie B. Blade, MD, PhD 2001 University of Washington

Private Practice, Internal Medicine, Lynnwood, WA

Chad E. Hudson, MD, PhD 2001 University of Virginia Private Practice, Obstetrics & Gynecology, Hagerstown, MD

Mark J. Jameson, MD, PhD 2001 University of Maryland Associate Professor and DirectorDivision of Head and Neck Oncologic and Microvascular SurgeryDepartment of Otolaryngology - Head and Neck SurgeryCo-leader, Head and Neck/Endocrine Cancer Team, Emily Couric Clinical Cancer CenterUniversity of Virginia Health System

Deanne L. King, MD, PhD 2002 University of Arkansas Private Practice, Otolaryngology, Little Rock, AR

Richard A. Walgren, MD, PhD 2002 Washington University Medical Fellow and Medical Director, Oncology Clinical Development, Eli Lilly, Indianapolis, IN

Joseph R. Kelley, MD, PhD 2003 Medical College of Virginia

Assistant Professor, Radiology, University of TennesseeRadiation Oncology & Cyperknife Center, Knoxville, TN

Stewart M. Knoepp, MD, PhD 2003 Massachusetts General Hospital/Harvard

Private Practice, St. Joseph's Hospital, Ann Arbor, MI

Bryce A. Nelson, MD, PhD 2003 Vanderbilt University Associate Professor of Clinical Pediatrics, University of South Carolina School of Medicine/Adjunct Faculty, Virginia College of Osteopathic Medicine, Spartanburg, SC/Chairman, IRC-B, Greenville Hospital System/Medical Director, Division of Pediatric Endocrinology & Diabetes Program, Greenville Hospital System

Christopher D. Willey, MD, PhD 2003 Vanderbilt University Associate Professor, Radiation Oncology, Director of Kinome Core, University of Alabama Birmingham

Scott P. Commins, MD, PhD 2004 University of Virginia Associate Professor, Thurston Research Center, Division of Allergy, Immunology & Rheumatology, Department of Medicine & Pediatrics, The University of North Carolina at Chapel Hill

Christopher A. Wells, MD, PhD 2004 Vanderbilt University Cardiologist, American Family Care/Veterans Health Administration, Nashville, TN

Ralph J. Barker, MD, PhD 2005 MUSC Bradenton Trauma Surgical Group, Brandenton, FL

Kevin P. Becker, MD, PhD 2005 Yale Assistant Professor, Neurology, Division Medical Neuro-oncology, Yale University School of Medicine

Michael L. Bernard, MD, PhD 2005 Vanderbilt University Cardiac Electrophysiologist, Oschsner ClinicChristopher V. Crosby, MD, PhD 2005 Emory University Clinical Assistant Professor, Dermatology,

UCSD



Michelle B. Crosby, MD, PhD 2005 Emory University Clinical Assistant Professor, Ophthalmology, UCSD

Ron J. Feldman, MD, PhD 2005 Cleveland Clinic Assistant Professor, Dermatology, Emory University School of Medicine

Joshua M. Hubbard, MD, PhD 2005 University of Virginia Private Practice, Asheville Radiology Associates, Asheville, NC

Benjamin J. Pettus, MD, PhD 2005 Washington University, St. Louis

Full Clinical Professor, Radiology, Riverside Health System, Newport News, VA

Vijay U. Rao, MD, PhD 2005 Duke University Staff Cardiologist, St. Francis Hospital, Indianapolis, INDirector, Cardiovascular ResearchDirector, CardioOncology ClinicDirector, In-patient Heart FailureCo-Director, Anticoagulation ClinicClinical Assistant Professor, Marian College of Osteopathic Medicine

Nicole Redmond, MD, PhD, MPH 2005 Emory University Medical OfficerNational Heart, Lung, and Blood Institute (NHLBI)Division of Cardiovascular Sciences (DCVS)Clinical Applications and Prevention Branch (CAPB)

Stephen F. Shafizadeh MD, PhD 2005 University of Chicago Private Practicem Neurosurgery, Arkansas Neuroscience Institute

Justin Turner, MD, PhD 2006 Johns Hopkins Assistant Professor, Otolaryngology-Head and Neck SurgeryAssistant Professor, Biomedical Engineering, Vanderbilt University School of Medicine

John Yordy, MD, PhD 2006 MD Anderson Radiation Oncologist, Anchorage & Valley Radiation Therapy Centers, Anchorage, AK

Zachary Bowman, MD, PhD 2007 UCSD Maternal/Fetal Medicine Specialist, MAHEC Ob/Gyn Specialist, Asheville, NC

Lena Heung, MD, PhD 2007 Baystate/Tufts Affiliate Fellow, Infectious Diseases, Memorial Sloan Kettering Cancer Center

Shantae Jenkins, MD, PhD 2007 MUSC Hospitalist, Colleton Medical CenterEric Sribnick, MD, PhD 2007 Emory University Pediatric Neurosurgeon at Nationwide

Children's Hospitalin Columbus, OH

Tarek Taha, MD, PhD 2007 Indiana University Orthopedic Trauma Surgeon, St. Mary's of Michigan Orthopedic Assoc, Saginaw, MI

David Arrington, MD, PhD 2008 Georgetown University/MUSC

Upper Savannah Radiological Associates, Greenwood, SC

Mary Lee Gregory, MD, PhD 2008 Baystate/Tufts Affiliate Assistant Professor, Pediatric Neurology, Augusta University Medical Center

Gregor Krings, MD, PhD 2008 Mass. General Hospital/UCSF

Assistant Professor, Pathology, UCSF

John Shea, MD, PhD 2008 Allegheny General Resident, Emergency Medicine, Alleghany General Hospital

Laura Spruill, MD, PhD 2008 MUSC Assistant Professor, Pathology & Laboratory Medicine, MUSC

Brice Williams, MD, PhD 2008 University of Utah Adjunct Faculty, Ophthalmology, University of Utah



Saeed ElOjeimy, MD, PhD 2009 University of Washington

Assistant Professor, Radiology, University of New Mexico

Jason Guichard, MD, PhD 2009 University of Alabama-Birmingham

Fellow, Advanced Heart Failure and Transplant Cardiology, UAB

Mark Hallman, MD, PhD 2009 MUSC/Fox Chase Cancer Center

Assistant Professor, Radiation Oncology, Fox Chase Cancer Center

Amanda Galloway Hartke, MD, PhD 2009 University of Texas Southwestern-Dallas

Pediatric Hospitalist, Children's Hospital, Greenville Health SystemM4 Pediatric Director, Assistant ProfessorUSC School of Medicine Greenville

Youssef Zeidan, MD, PhD 2009 Stanford University Assistant Professor & Program Director, Radiation OncologyAssistant Professor, Anatomy and Cell Biology, American University of Beirut

Rany Abdallah, MD, PhD 2010 MUSC/Lenox Hill/Rush

Assistant Professor, Anesthesia, Temple University Health Systems

Jamie L. Fraser, MD, PhD 2010 National Institutes of Health

Attending Physician, Division of Genetics and Metabolism, Children's National Medical CenterAssistant Professor, George Washington University

Mona Taleb, MD, PhD 2010 Mt. Sinai Medical Center-Miami/Wayne State

Fellow, Advanced GI Surgery, Thomas Jefferson University

Juan C. Varela, MD, PhD 2010 Johns Hopkins University

Assistant Professor, Hematology/Oncology, MUSC

Jonathan Butler, MD, PhD 2011 Vanderbilt Riverside Neurology Specialists, Newport News, VA

Justin Ellett, MD, PhD 2011 MUSC Private Practice, Lowcountry UrologyLoretta Jophlin, MD, PhD 2011 Mt. Sinai Fellow, Transplant Hepatology, Mayo ClinicJason Lockrow, MD, PhD 2011 University of

WashingtonFellow, Clinical Neurophysiology, University of Washington

Phillip Moschella, MD, PhD 2011 University of Cincinnati

Clinical Assistant Professor, Emergency Medicine, Greenville Hospital System

Michael O'Quinn, MD, PhD 2011 MUSC/VCU Fellow, Cardiovascular Disease, Virginia Commonwealth University

Brian Snarr, MD, PhD 2011 University of Texas-Southwestern

Pediatric Cardiology, Children's Hospital of Philadelphia

Jarrett Walsh, MD, PhD 2011 University of Iowa Assistant Professor, Otolaryngology, University of Iowa

Adnan Al-Ayoubi, MD, PhD 2012 MUSC Resident, Integrated Thoracic Surgery, University of Iowa

DeAnna Baker Frost, MD, PhD 2012 Duke Fellow, Rheumatology, MUSCChristopher Gault, MD, PhD 2012 University of

PennsylvaniaFellow, Surgical Pathology, University of Pennsylvania

Linda Heffernan-Stroud, MD, PhD2012 Eastern Virginia Medical Center

Private Practice, Dermatology, Tidewater Skin Care, Kitty Hawk, NC

Russell Jenkins, MD, PhD 2012 Mass. General Fellow, Medical Oncology, Dana Farber Cancer Institute

Khaled Moussawi, MD, PhD 2012 Mass. General NIH Clinical Fellow, NIDABehavioral Neurology and Neuropsychiatry Fellow, Johns Hopkins Medicine



Thomas Mullen, MD, PhD 2012 Tufts/University of Washington

Resident, Radiation Oncology, University of Washington

Ryan M. Rhome, MD, PhD 2012 MUSC/Mt. Sinai Assistant Professor, Radiation Oncology, Indiana University

Adrian Sproul, MD, PhD 2012 MUSC/UNC Chapel Hill

Paramedic

Andre Eaddy, MD, PhD 2013 Vanderbilt Clinical and Research Fellow in GastroenterologyPhysician-Scientist Training Program, ABIM Research Pathway and Harrison SocietyVanderbilt University Medical Center

Joseph Palatinus, MD, PhD 2013 Beth Israel Deaconess Fellow, Cardiology, Cedars Sinai Medical Center, Los Angeles, CA

Amena Smith, MD, PhD 2013 Johns Hopkins Fellow, Neurodevelopmental Disabilities, Kennedy Krieger Institute/Johns Hopkins

Kyle Strickland, MD, PhD 2013 Brigham and Women’s Hospital

Assistant Professor, Pathology, Duke University

Peter Tang, MD, PhD 2013 University of Minnesota

Fellow, Vitreoretinal Surgery, Stanford University

Parker Wilson, MD, PhD 2013 Yale Fellow, Renal & Genitourinary Pathology, Yale New Haven

Joseph Cheng, MD, PhD 2014 MUSC Resident, Psychiatry, MUSCAnna-Maria De Costa, MD, PhD 2014 MUSC/University of

WisconsinResident, Radiation Oncology, University of Wisconsin

George Daniel Grass, MD, PhD 2014 Greenville Hospital System/Moffitt Cancer Center

Resident, Radiation Oncology, Moffitt Cancer Center Tampa

Armina Omole, MD, PhD 2014 University of Pennsylvania

Resident, Neurology, University of Pennsylvania

David M. Perry, MD, PhD 2014 Greenville Hospital System/MUSC

Resident, Dermatology, MUSC

Sahar Saddoughi, MD, PhD 2014 Mayo School of Medicine

Resident, Cardiothoracic Surgery, Mayo School of Medicine

Lee Wheless, MD, PhD 2014 Vanderbilt Resident, Dermatology, Vanderbilt UniversityJoseph Alge, MD, PhD 2015 Baylor Resident, Pediatric Physician Scientist, Baylor

UniversityObaidullah Aseem, MD, PhD 2015 Mayo School of

MedicineResident, Medicine/GI Physician Scientist Track, Mayo Clinic

Tiffany Baker, MD, PhD 2015 MUSC Resident, Pathology, MUSCThomas Beckham, MD, PhD 2015 Memorial Sloan

KetteringResident, Radiation Oncology, Sloan Kettering

Mohammad Dahrouj, MD, PhD 2015 Indiana Univ/Harvard Resident, Ophthalmology, HarvardRebecca Knackstedt, MD, PhD 2015 Cleveland Clinic Resident, Plastic Surgery, Cleveland Clinic

Keely Marshall, MD, PhD 2015 Loyola/University of Pittsburgh

Resident, Dermatology, University of Pittsburgh

Ahmad Mashmoushi, MD, PhD 2015 University of Texas Southwestern-Dallas

Resident, Pediatrics, UT Southwestern Dallas

Alton Sutter, MD, PhD 2015 Beth Israel Deaconess Resident, Surgery, Beth Israel Deaconess Medical Center

Joseph Taylor, MD, PhD 2015 Yale Resident, Psychiatry Neuroscience Research Training Program, Yale

Brandon S. Bentzley, MD, PhD 2016 Stanford Resident, Psychiatry, Stanford University



Laura Briggs, MD, PhD (Winters) 2016 Medical College of Georgia

Resident, Psychiatry, Medical College of Georgia

Jennifer Harmon, MD, PhD 2016 Children’s National Medical Center

Resident, Pediatric Neurology, Children's National Medical Center

Christopher Bryce Johnson, MD, PhD 2016 Memorial Sloan-Kettering

Resident, Radiation Oncology, Memorial Sloan Kettering

Anthony P. Leonard, MD, PhD 2016 Washington University Resident, Ophthalmology, Washington University

Sarah Tucker Price, MD, PhD 2016 Trident Medical Center

Resident, Family Medicine, Trident Medical Center

Saleh Rachidi, MD, PhD 2016 Johns Hopkins Hospital

Resident, Dermatology, Johns Hopkins Medical Center

Xiaoyi Tina Zhang, MD, PhD 2016 MUSC Resident, Pediatrics, MUSCCraig J. Kutz, MD, PhD 2017 UCSD Resident, Emergency Medicine, UCSD

Jennifer L. Scott, MD, PhD 2017 Washington Hospital Center

Resident, Medicine/Dermatology, Washington Hospital Center

Joshua A. Smith, MD, PhD 2017 Baylor University Resident, Pediatric Neurology, BaylorRyan M. Whitaker, MD, PhD 2017 UCSD/Vanderbilt Transitional Medicine, UCSD

Resident, Radiation Oncology, Vanderbilt

HIGHLIGHTS (2016-2017) This year is most notable for the change in leadership for the MSTP. Dr. Nancy DeMore, BMW Endowed Chair in Cancer Research and Professor of Surgery, was named the new program director and Dr. Donald Menick, Professor of Biochemistry and Molecular Biology, was named associate program director. Special thanks goes to Dr. Robin Muise-Helmericks for her years of devoted service to the MSTP as associate program director. Dr. DeMore and Dr. Menick bring a set of complementary skills that will provide outstanding leadership for the program. The national prominence of the program continues to increase significantly. This year, we had 191 applications. The quality of the applicant pool remains very high. We interviewed a total of 39 applicants. The average GPA and MCAT scores of the interviewees were 3.86 and 515, respectively. We had a total of 8 new students matriculate. Their GPA and MCAT scores were 3.88 and 511, respectively. The 8 matriculants had a total of 47 publications and turned down 15 acceptances from other programs. Of particular note, is the extensive undergraduate research experiences that the applicants had. It was clear during the recruitment process that we continue to compete with the best programs in the country. Elizabeth Farris Langley, incoming first year student, was awarded the annual MUSC Physicians/MSTP scholarship. She also received the Suzann Pershing Award. Daniel Wood received the SCE&G Scholarship. From the Hollings Cancer Center, Hyunwoo Tony Kwon received the Abney scholarship for the second year. Sagar Bajpai also received the Abney scholarship. The nine students who were awarded NIH predoctoral fellowships from the training grant are Dimitrios Arhontoulis, David Braak, John Grayson Evans, Jamie Mills, Alexander Oles, Guillermo Rangel Rivera, Matthew Roberts, Victoria Spadafora and Shannon Weber. The visiting professor seminar series has been reactivated. The plan is to have one to two speakers during the upcoming year. Dr. Skip Brass, Director, University of Pennsylvania MSTP, will be visiting in January. Congratulations to Jacob Bowers and Ken Noguchi who received Ruth Kirschstein NSRA fellowships. Our success rate for obtaining the NRSA fellowships continues to be approximately twice the national average, which is 30%. Currently, 8 of our students are the recipients of a competitive intramural or extramural individual fellowship. Our new students and their undergraduate institutions are listed below.

Dimitrios Arhontoulis Drexel University Davis Borucki Boston University Stephen Gadomski University of Scranton Nour Hijazi American University of Beirut Elizabeth Farris Langley College of Charleston Emilie McKinnon Ku Leuven University/MUSC Victoria Spadafora Pennsylvania State University Park

Daniel Wood University of South Carolina This year we graduated four students.

Field of Study Institution for Residency Craig Kutz Emergency Medicine UCSD Jennifer Scott Medicine/Dermatology Washington Hospital Center Joshua Smith Pediatric Neurology Baylor University Ryan Whitaker Radiation Oncology UCSD/Vanderbilt

Vivian Chioma was appointed to the MUSC Student Leadership Society. Mohammed Dany was inducted into the Alpha Omega Alpha Honor Society. The monthly student seminar series, which are organized by the students, continues to be very successful. It is scheduled for the fourth Monday of each month at 5:00 p.m. Faculty from our institution presented informal research seminars at each of the meetings. These interactions have resulted in several students choosing the presenters as mentors for research projects. This year, 8 students who were ready to defend their dissertation presented their research. This provided an excellent venue for them to practice their presentation. It also allowed the other students in the program to learn about their colleague’s research.

December 12 Daniel Neitzke December 14 Danielle Lowe April 5 Jacob Bowers April 13 Ali Alawieh May 1 Daniel Herr June 5 Douglas Roberts-Wolfe June 12 Ken Noguchi June 13 Fahmin Basher

Our Translational Medicine Seminar series has been a great success. Each one of our senior students paired with one of our faculty to present a clinical case. This was followed by a research discussion by the faculty member focused on the disease that was presented. The topics and speakers are listed below: January 9 Craig Kutz and Edward Jauch, MD, MS, FAHA “Intracerebral Hemorrhage” February 13 Joshua Smith, Ken Holden, MD & Gisele Matheus, MD

"Neurogenetics and imaging in individuals with Allan-Herndon-Dudley syndrome"

April 3 Ryan Whitaker and Graham Warren, MD, PhD "Smoking Cessation and Radiation Therapy Response" April 17 Jennifer Scott and DeAnna Frost, MD, PhD

"The Effects of Estradiol on Dermal Fibrosis in Scleroderma"

The Translational Sciences Clinics have proven to be a very rewarding and successful experience for our students. Both the students and faculty have provided very positive evaluations. During this past year 9 students; Ali Alawieh, Fahmin Basher, Jacob Bowers, Daniel Herr, Jamie Mills, Danielle Lowe, Daniel Neitzke, Ken Noguchi, Douglas Roberts-Wolfe successfully defended their Ph.D. dissertations. This has also been an exciting year for many of our students. Ken and Katie Noguchi welcomed baby boy Jaydee on August 20, Doug and Christine Roberts-Wolfe welcomed baby girl Lena in January. Our students continue to garner many honors and awards that you will see listed after their names. Including the incoming class, we currently have 56 students in the program. GOALS FOR 2017-2018

• We will continue to try to identify philanthropic support for the program

• Increase the size and quality of our applicant pool

• Submit a successful competing renewal application for the program in May 2018

• Re-evaluate the MSTP’s activities and programs

AWARDS AND HONORS (2016-2017) Listed below are the many honors and awards our students have garnered during the past year. Student’s Name (Year of Matriculation) Ali Alawieh (2013) Young Arab Neuroscientist Travel Award, Society for Neuroscience Annual Meeting 2016, San Diego, CA 2016 1st Place Oral Presentation Winner, Perry V. Halushka MUSC Research Day, Charleston, SC 2016 Best Poster Award, AAP/ASCI/APSA Annual Meeting, Chicago, IL. 2017 AAP/ASCI/APSA Joint Meeting Travel Award, AAP/ASCI/APSA Annual Meeting, Chicago, IL 2017 Oral presenter travel award, Society for Clinical and Translational Research Annual Meeting, Chicago, IL 2017 International Stroke Conference Junior Investigator Travel Award, American Heart Association, Houston, TX 2017 Krishna Bharani (2013) NIH/AFAR T35 Medical Student Training in Aging Research (MSTAR) Scholar - Harvard Medical School 2016-2017 Combining Clinical and Research Careers in Neuroscience Symposium Scholar 2017 Jacob Bowers (2011) Willard and Betty Peterson Award, Perry V Halushka MUSC Research Day 2016 Robert Cameron (2011) NIH NRSA F30 DK104550 2014-2018 Daniel T. O'Connor Young Investigator Award, Catecholamine Society 2017 Yamamura Award, Best Oral Presentation, University of Arizona College of Medicine Data Blitz 2017 Kevin Caulfield (2016) NIH/MSTP Predoctoral Fellowship Training Grant, GM008716 2016-2017

Vivian Chioma (2014) IMSD Scholar 2016-2017 Student Leadership Society Inductee 2016-2017 Presidential Scholars Program Fellow 2016-2017 Recipient of National Institute of Drug Abuse Travel Award for Cold Spring Harbor Laboratory Course: Cellular Biology of Addiction 2017 Recipient of Sandy Nelson Memorial Award: Excellence in Communication 2017 Recipient of Carl Storm Underrepresented Minority Fellowship (CSURM) 2017 Cannabinoid Function in the CNS Gordon Research Conference 2017 Stewart Cox (2015) NIH/MSTP Predoctoral Fellowship Training Grant, GM008716 2016-2017 Mohammed Dany (2013) Alpha Omega Alpha – Inducted in junior year 2016 SID Student Research Travel Award, Society for Investigative Dermatology, Annual meeting, Portland OR Abstract selected for drug discovery mini-symposium- oral presentation 2017 First Place Best Poster Presentation Award, Medicine Research Symposium, MUSC 2017 Best medication review award, Pediatrics Clerkship, MUSC 2017 Maya Eid (2015) Young Investigator Travel Award, International Behavioural and Neural Genetics Society, Madrid, Spain 2017 John Grayson Evans (2016) NIH/MSTP Predoctoral Fellowship Training Grant, GM008716 2016-2017 George Russell Glenn (2010) Magna Cum Laude award for outstanding abstract at the 24th annual ISMRM meeting 2016 Travel award to Third Annual Academic Interventional Radiology Symposium 2016 Original scientific artwork selected as the cover art for American Journal of Neuroradiology Volume 37, Issue 7 2016 First author publication selected for Editors’ Choice (PMCID: 5226062) 2016 Co-first author publication selected for Editors’ Choice (PMICID: 4946981) 2016 NIH/MSTP Predoctoral Fellowship Training Grant, GM008716 2016-2017 Joseph Guy (2011) Outstanding Poster Award - Global Doctoral Partnerships Annual Workshop 2017 David Hartmann (2012) NIH/NINDS Ruth L. Kirschstein NRSA Individual Predoctoral Fellowship F30 2015-2019

Daniel Herr (2011) NIH/NHLBI Ruth L. Kirschstein NRSA Individual Predoctoral Fellowship F30 HL129629 2015-2019 Institutional Representative, American Physician Scientists Association 2016-2017 1st Place Oral Presentation, MUSC MSTP Annual Research Day 2016 1st Place Poster Presentation, MUSC Department of Medicine Research Symposium 2017 Alice Kim (2016) NIH/MSTP Predoctoral Fellowship Training Grant, GM008716 2016-2017 Hannah Knochelmann (2015) NIH/MSTP Predoctoral Fellowship Training Grant, GM008716 2016-2017 12/12 Theme Honors COM Year 2 2016-2017 12/12 Block Honors COM Year 2 2016-2017 Hyunwoo Tony Kwon (2014) Abney Foundation Scholarship 2016-2017 American Physician Scientist Association Excellent Mentor Award 2017 Allison Meadows (2015) NIH/MSTP Predoctoral Fellowship Training Grant, GM008716 2016-2017 Jamie Mills (2011) 1st place PhD Presenter of the Year, Pathology & Laboratory Medicine Seminar Series 2016-2017 2nd place PhD VII Oral Presentation, Perry V. Halushka MUSC Research Day 2016 Christopher Mullins (2015) NIH/MSTP Predoctoral Fellowship Training Grant, GM008716 2016-2017 Daniel Neitzke (2010) NIH/MSTP Predoctoral Fellowship Training Grant, GM008716 2016-2017 Ken Noguchi (2012) Ruth L. Kirschstein National Research Service Award, NCI, 1F30CA203269-01 2015-2019 Elizabeth Ogunrinde (2014) Infectious Disease Society of America (IDSA) Medical Scholar 2017 Rheumatology Research Foundation (RRF) Medical and Graduate Student Preceptorship 2017 Alexander Oles (2016) Abney Foundation Scholarship 2016-2017

Sanket Pattanaik (2013) Appointee to T32: Training to improve cardiovascular therapies 2016-2017 Guillermo Rangel Rivera (2016) Pershing Scholarship Recipient 2016-2017 SCE&G Scholarship Recipient 2016-2017 Matthew Roberts (2016) MUSC Physicians Scholarship Recipient 2016-2017 CARES Clinic, Board Member & Grant Writer 2016-2017 Catherine Svetcharnik (2015) NIH/MSTP Predoctoral Fellowship Training Grant, GM008716 2016-2017 Danh Tran (2014) NIH/NHLBI Cardiovascular Predoctoral Fellowship Training Grant, HL007260 2016-2017 Jonathan Turner (2013) Perry V. Halushka MUSC Research Day, Grad 1 & 2, First Place Poster 2016 Association for Clinical and Translational Science Conference, Burroughs-Wellcome Fund Travel Award 2016 Southeastern Predoctoral Clinical and Translational Research Award, TL1 Trainee 2016-2017 Shannon Weber (2015) Perry V. Halushka MUSC Research Day, First Prize, Masters/Professional/Clinical 2016 Katelyn Williams (2012) F30 NRSA Fellowship, NCI F30CA216921 titled “Investigation of Cdc34 Molecular Recognition by its Enzyme Partners, Uba1 and SCF Ligases 2017-2021 PUBLICATIONS Our students have also been very productive in their research endeavors, as witnessed by their publication records. In 2016-2017 they authored or co-authored 74 manuscripts that have been published or are in press. They submitted 94 abstracts for presentation. PRESENTATIONS AND ABSTRACTS Ali Alawieh (2013) Alawieh A, Langley F, Kulik L, Tomlinson S. Injury Site-Specific Complement Inhibition as A Novel and Translational Approach to Improve Chronic Outcomes After Ischemic Stroke. MUSC MSTP Student Research Day, Charleston, SC, September 2016.

Langley EF, Alawieh A, Scheiber M, Tomlinson S. A Translational Strategy to Improve Chronic Recovery After Stroke Using Injury-site Targeted Inhibition of Complement Activation. Perry V. Halushka MUSC Research Day, Charleston, SC, November 2016. Alawieh A, Langley EF, Tomlinson S. Breaking the Spiral of Neurodegeneration After Stroke Using Transient and Local Inhibition of Complement Activation. Perry V. Halushka MUSC Research Day, Charleston, SC, November 2016. Alawieh A, Langley F, Tomlinson S. Improving Chronic Motor and Cognitive Recovery After Stroke Using Injury-site Specific Inhibition of Complement Activation. International Stroke Conference 2017. Houston, TX, February 2017 Alawieh A, Andersen M, Adkins DL, Tomlinson S. Targeted Inhibition of the Alternative Complement Pathway Enhances Rehabilitation-Induced Cognitive and Motor Recovery in a Murine Model of Chronic Stroke. International Stroke Conference, Houston, TX, February 2017 Alawieh A, Langley F, Tomlinson S. Co-targeting of Pathogenic Postischemic Self-Recognition by Natural Antibodies and Complement Activation Limits Chronic Neuroinflammation and Improves Outcomes After Experimental Stroke. AANS/CNS Joint Cerebrovascular Section Annual Meeting, Houston, TX, February 2017 Alawieh A, Langley F, Tomlinson S. Inhibiting post-stroke neuroinflammation by ischemia-targeted complement modulation. Society for Neuroscience, San Diego, CA, October 2016. Sagar Bajpai (2015) Bajpai S, Jin H, Diehl A. Identification of Novel Substrates from SCFFBXL8. MUSC MSTP Student Research Day, Charleston, SC, September 2016. Fahmin Basher (2008) Basher F, Jeng E, Wong H, Wu JD. Cooperative Therapeutic Anti-tumor Effect of IL-15 Agonist ALT-803 and Co-targeting Soluble NKG2D Ligand sMIC. Perry V. Halushka MUSC Research Day(oral), November 4, 2016 Dhar P, Basher F, Zhang J, Wu JD. Modulation of Signaling and Metabolic Preference of NK Cells By Different Forms of NKG2D Ligands and Its Implications, Perry V. Halushka MUSC Research Day(oral), November 4, 2016 Basher F, Jeng E, Wong H, Wu JD. Cooperative Therapeutic Anti-tumor Effect of IL-15 Agonist ALT-803 and Co-targeting Soluble NKG2D Ligand sMIC. Hollings Cancer Center Annual Retreat (poster), November 2016.

Basher F, Jeng E, Wong H, Wu JD. Cooperative Anti-tumor Effect of Soluble NKG2D Ligand MIC Neutralization and PD-1 Pathway Blockade. American Association of Immunologists Annual Meeting (poster), May 2017. Krishna Bharani (2013) Bharani KL, Columbo L, Ledreux A, Granholm AC. BDNF As a Biomarker For Alzheimer’s Disease. MUSC MSTP Student Research Day, Charleston, SC, September 2016. Bharani KL, Columbo L, Ledreux A, Granholm, AC. BDNF As a Biomarker for Alzheimer’s Disease. Perry V. Halushka MUSC Research Day, Charleston, SC, November 2016 Bharani, K.L., Ledreux, A., Carroll, S., Granholm, A.C. BDNF as a biomarker for Alzheimer’s disease. AAP/ASCI/APSA Annual Meeting, Chicago, IL, April 2017 Bharani, K.L. Deep Brain Stimulation in Alzheimer’s disease. Neurosurgery Research Day & Christian Vera Lecture, Charleston, SC, April 2017 Bharani, K.L., Szeles, D, Sorrell, A., Granholm, A.C., Benitez, A. Serum Brain-Derived Neurotrophic Factor (BDNF) Levels Correlate with Hippocampal and White Matter Volumes in Older Adults. 13th Annual Aging Research Day: “Health and Technology Supports for Aging-in-Place”, Columbia, SC, April 2017 Daniel Bonthius (2015) Yao H, Gross R, Bonthius D. The Development Of A Kyphoscoliosis Porcine Model For The Study Of Novel Corrective Spinal Instrumentation. MUSC MSTP Research Day. September 2016. Jacob Bowers (2011) Bowers JS, Nelson MH, Majchrzak K, Bailey SR, Diven MA, Schwartz KM, Rohrer B, Gattinoni L, Paulos CM. Th17 Cells Retain Antitumor Efficacy After Long-Term Ex Vivo Expansion. MUSC MSTP Research Day. September 2016 Bowers JS, Nelson MH, Majchrzak K, Bailey SR, Rohrer Baerbel, Atkinson C, Gattinoni, Paulos CM. Th17 Cells Are Refractory to Senescence Retaining Robust Antitumor Activity After Long-term Ex Vivo Expansion. Perry V. Halushka MUSC Research Day, Charleston, SC, November 2016. Bowers JS, Nelson MH, Majchrzak K, Bailey SR, Rohrer B, Kaiser ADM, Atkinson C, Gattinoni L, Paulos CM. Th17 cells are refractory to senescence retaining robust antitumor activity after long-term ex vivo expansion. Keystone C7 symposium, Whistler British Columbia, Canada, 19-23 March 2017

Bowers JS, Nelson MH, Majchrzak K, Bailey SR, Rohrer B, Kaiser ADM, Atkinson C, Gattinoni L, Paulos CM. Th17 cells are refractory to senescence retaining robust antitumor activity after long-term ex vivo expansion. APSA, Chicago Illinois, USA, 21-23 April 2017 Robert Cameron (2011)

Cameron RB, Beeson CC, Schnellmann RG. The Role Of G-Akt Signaling In 2-Adrenoceptor-Mediated Mitochondrial Biogenesis. MUSC MSTP Research Day. September 2016 Cameron RB, Beeson CC, Schnellmann RG. The role of Gbg-dependent signaling in formoterol induced mitochondrial biogenesis. GRKs and Arrestins: From Structure to Disease, Saxtons River, VT Cameron RB, Beeson CC, Schnellmann RG. Identifying receptor-ligand interactions that drive Gbg-dependent signaling. Experimental Biology, 2017, Chicago, IL Cameron RB, Beeson CC, Schnellmann RG. Activation of Gbg-Akt signaling mediates the differential effects of b2-adrenoceptor agonists on mitochondrial biogenesis. American Society of Nephrology Kidney Week, 2016, Chicago, IL Vivian Chioma (2014) Chioma V, Spencer S, Kalivas P. CB1 Receptor Antagonist, Rimonabant, Attenuates THC Self-Administration Behavior in Rodents. Frontiers in Neuroscience Conference, Charleston, SC, March 2017 Mohammed Dany (2013) Dany M, Ogretmen B. LCL-461 is a Lipid Based Therapeutic Drug That Overcomes Drug Resistance in Acute Myeloid Leukemia. Perry V. Halushka MUSC Research Day, Charleston, SC, 2016 Dany M, Ogretmen B. Fighting Cancer with Fat: Utilizing ceramide to induce lethal mitophagy. Society for Investigative Dermatology-Drug Discovery session. April 28, 2017. Selected oral presentation. Dany M, Ogretmen B. Fighting Cancer with Fat: Utilizing ceramide lipid to induce lethal mitophagy. Medicine Research Symposium, Medical University of South Carolina. March 25, 2017. Maya Eid (2015) Eid M, Pullman D, Jhou T. The Heritability of Cocaine Conditioned Avoidance Behavior. MUSC MSTP Student Research Day, Charleston, SC, September 2016. Eid M, Pullman D, Jhou T. The Heritability of Cocaine Conditioned Avoidance Behavior. Society for Neuroscience Conference, San Diego, CA, November 2016.

Eid M, Pullman D, Li H, Jhou T. Cocaine Avoidance and Punishment Resistance: Two Heritable Phenotypes that Influence Addiction. Neuropalooza, Charleston, SC, February 2017. Eid M, Pullman D, Li H, Jhou T. Cocaine Avoidance and Punishment Resistance: Two Heritable Phenotypes that Influence Addiction. Frontiers in Neuroscience, Charleston, SC, March 2017. Eid M, Pullman D, Li H, Jhou T. Cocaine Avoidance and Punishment Resistance: Two Heritable Phenotypes that Influence Addiction. International Behavioural and Neural Genetics Society, Madrid, Spain, May 2017. George Russell Glenn (2010) Helpern JA, Glenn, GR, Benitez A, Falangola MF, Jensen JH, Deardorff R. Automated fiber quantification identifies the extent of white matter integrity loss concurrent to hippocampal atrophy. International Society for Magnetic Resonance in Medicine, Honolulu, Hawaii, 2017 McKinnon ET, Jensen JH, Glenn GR, Shih A, Helpern JA. Exploring multidirectional cortical diffusion in mice using diffusional kurtosis imaging. International Society for Magnetic Resonance in Medicine, Honolulu, Hawaii, 2017. Moss H, Glenn GR, Jensen JH. Fiber ball imaging: a qualitative and quantitative analysis. International Society for Magnetic Resonance in Medicine, Honolulu, Hawaii, 2017. Adisetiyo V, Gray KM, Shaw CB, Glenn GR, Jensen JH, Helpern JA. Structural connectivity in children and adolescents with attention-deficit/hyperactivity disorder who lack substance use history. Organization for Human Brain Mapping, Vancouver, Canada, 2017 McKinnon ET, Glenn GR, Wabnitz A, Jensen JH, Helpern JA, Bonilha L, Fridriksson J. Therapy-related structural plasticity of temporal white matter is related to naming recovery in aphasia. International Stroke Conference, Houston, TX, 2017. McKinnon ET, Glenn GR, Jensen JH, Helpern JA, Bonilha L, Fridriksson J. Investigating microstructural changes of the ipsilateral SLF and ILF underlying speech therapy using advanced diffusion MRI techniques. Society for the Neurobiology of Language, London, England, 2016. McKinnon ET, Glenn GR, Jensen JH, Helpern JA, Bonilha L, Fridriksson J. Examining the relationship between semantic performance and inferior longitudinal fasciculus integrity in chronic post-stroke aphasia using advanced diffusion MRI techniques. Perry V. Halushka MUSC Research Day, Charleston, SC, 2016.

Keller SS, Glenn GR, Weber B, Kreilkamp BA, Jensen JH, Richardson MP, Bonilha L. Resection extent of the uncinate fasciculus and postoperative seizure outcome in temporal lobe epilepsy. European Congress on Epileptology, Prague, Czech Republic, 2016. Keller SS, Glenn GR, Weber B, Kreilkamp BA, Jensen JH, Richardson MP, Bonilha L. Predicting outcome after surgery for temporal lobe epilepsy using Automated Fibre Quantification. Organization for Human Brain Mapping, Geneva, Switzerland, 2016. Glenn GR, Bonilha L, Kreilkamp B, Richardson MP, Weber B, Keller SS. Automated fibre quantification of the fornix predicts outcome after surgery for intractable temporal lobe epilepsy. International Society for Magnetic Resonance in Medicine, Suntec City, Singapore, 2016. Glenn GR, Bonilha L, Kreilkamp B, Richardson MP, Weber B, Keller SS. Automated fibre quantification of the fornix predicts outcome after surgery for intractable temporal lobe epilepsy. International Society for Magnetic Resonance in Medicine, Suntec City, Singapore, 2016. American Physician Scientist Association Annual Meeting, Chicago, IL, 2016. Glenn GR, Jensen JH, Keller SS, Helpern JA, and Bonilha L. Cytoarchitectonic abnormalities along white matter pathways in temporal lobe epilepsy: Combining diffusional kurtosis imaging and automated fiber quantification. International Society for Magnetic Resonance in Medicine, Suntec City, Singapore, 2016. Joseph Guy (2011) Guy JR. From Radio Waves to Pixels: Signal Generation and Image Formation in MRI. Theory of Living Matter tutorial. Pub talk. Cambridge, UK, February 2016. Guy JR, Franklin RM, Brindle KB. Magnetic Resonance Imaging of Brain Inflammation. Biochemistry Department student research day. Talk. Cambridge, UK, July 2016. Guy JR, Brindle KB, Franklin RM. RF Coil and Pulse Sequence Development in Magnetic Resonance Microscopy. Stem Cell Institute student research day. Talk. Cambridge, UK, July 2016. Guy JR, Franklin RM, Brindle KB, Reich DS. Ultra-high resolution MR histology using ROI-extraction and SNR David Hartmann (2012) Hartmann DA, Grant RI, Shih AY. Probing The Contractility Of Capillary Pericytes In Vivo With Optogenetics. MUSC MSTP Research Day. September 2016 Hartmann DA, Grant RI, Harrill SA, Noonan TE, Shih AY (2016) Probing the contractility of capillary pericytes in vivo with optogenetics. Poster presentations at Perry V. Halushka Student Research Day, Charleston, SC, November 2016

Hartmann DA, Grant RI, Harrill SA, Noonan TE, Shih AY (2016) Probing the contractility of capillary pericytes in vivo with optogenetics. Poster presentations at Society for Neuroscience Annual Meeting, San Diego, CA., November 2016. **Selected by the Society for Neuroscience as a Hot Topic Daniel Herr (2011) Herr DJ, Aune SE, Ball LE, Chou JC, Menick DR. Class I Histone Deacetylases Localize to Cardiac Myocyte Mitochondria and Contribute to Ischemia Reperfusion Injury. Poster presentation at the ASCI/AAP/APSA Joint Meeting, Chicago, IL, April 22nd 2017. Herr DJ, Aune SE, Baarine M, Li X, Ball LE, Lemasters JJ, Chou JC, Beeson CC, Menick DR. HDAC1 localizes to myocyte mitochondria and exacerbates cardiac I/R injury. Poster presentation at the MUSC Department of Medicine Research Symposium, Charleston, SC, March 24th, 2017. Rountree CA, Zahra A, Russo JK, O’Keefe J, Andresen NS, Mott SL, Herr DJ, Allen BG, Sharma AK, Bhatia S, Buatti JM, Watkins JM. Once- (QD) versus Twice-Daily (BID) Radiotherapy (RT) plus Concurrent Chemotherapy for Limited-Stage (LS) Small-Cell Lung Cancer (SCLC): A Comparative Outcomes Analysis. Poster presentation at the Multidisciplinary Thoracic Cancers Symposium, San Francisco, CA March 16-18th, 2017. Herr DJ, Aune SE, Nguyen XX, Bethard JR, Ball LE, Menick DR. Class I Histone Deacetylases Localize to Cardiac Myocyte Mitochondria and Contribute to Ischemia-Reperfusion Injury. Oral presentation at the Perry V. Halushka MUSC Research Day, Charleston, SC, November 4th, 2016. Herr DJ. Class I Histone Deacetylases Exacerbate Cardiac I/R Injury and Modify the Mitochondrial Acetylome. Oral presentation at the annual MUSC MSTP Research Day, Charleston, SC, July 23rd, 2016. Nathaniel Jensen (2013) Jensen N, Cheung HW. Developing Novel Combination Therapy For GAB2-Driven Ovarian Cancer. MUSC MSTP Research Day. September 2016 Jensen NJ, Cheung HW. Defining downstream effectors critical for GAB2 oncogene induced tumorigenesis. HCC Scientific Research Retreat, Charleston, SC, October 2016. Hannah Knochelmann (2015) Knochelmann H, Nelson MH, Bowers JS, Neitzke DJ, Meek ME, Paulos CM. Infusion of fewer T cells streamlines potent antitumor response in adoptive immunotherapy. MUSC MSTP Research Day, Charleston, SC, July 2016.

Knochelmann H, Nelson MH, Bowers JS, Neitzke DJ, Meek ME, Paulos CM. Infusion of fewer T cells streamlines potent antitumor response in adoptive immunotherapy. Perry V. Halushka MUSC Research Day, MUSC, Charleston, SC, November 2016. Jamie Mills (2011) Mills JN, Ivey B, Ethier S. WHSC1L1 and 8p11 Ampliconmediated Estrogen-independent Activation of ER-alpha in Luminal B Breast Cancers. Perry V. Halushka MUSC Research Day, MUSC, Charleston, SC, November 2016. Mills JN and Ethier SP. The 8p11 amplicon oncogenes ASH2L and NSD3 alter the epigenetic landscape and provide the foundation for novel application of epigenetic therapy in luminal B breast cancers. AACR Annual Meeting, Washington, DC, April 2017 Turner-Ivey B, Smith EL, Rutkovsky AC, Spruill LS, Mills JN, and Ethier SP. Development of mammary hyperplasia, dysplasia, and invasive ductal carcinoma in transgenic mice expressing the 8p11 amplicon oncogene NSD3 (WHSC1L1). AACR Annual Meeting, Washington, DC, April 2017. Mills JN. The 8p11-p12 Amplicon Oncogenes ASH2L and NSD3 Regulate Cell Cycle Progression via Epigenetic Alterations and Result in Overexpression and Estrogen-independent Activation of ERα. Dissertation Defense Seminar, Charleston, SC, May 2017. Mills JN. The 8p11-p12 Amplicon Oncogenes ASH2L and NSD3 Regulate Cell Cycle Progression via Epigenetic Alterations and Result in Overexpression and Estrogen-independent Activation of ERα. MSTP Seminar Series, Charleston, SC, May 2017. Mills JN. Epigenetic regulation of gene expression by the 8p11-p12 amplicon oncogene ASH2L in luminal B breast cancer. Pathology and Laboratory Medicine Seminar Series, Charleston, SC, April 2017. Ken Noguchi (2012) Noguchi K, Dalton A, Howe P. mRNA Regulation Of The Oncogene ILEI In Melanoma. MUSC MSTP Research Day. September 2016 Noguchi K, Dalton A, McCall B, Howe PH. BRAF/MAPK Signaling Regulates ILEI, Which Contributes to the Low-MITF/invasive Melanoma Phenotype. Perry V. Halushka MUSC Research Day, Charleston, SC, November 2016. Alexander Oles (2016) Oles A, Bu Y, Diehl A. Role of miR-217 in the UPR during ER stress. Perry V. Halushka MUSC Research Day, Charleston, SC November 2016.

Sanket Pattanaik (2013) Pattanaik S, Arbra C, Bainbridhe H, Rhett JM, Fann S, Yost M. Rapid Anastomosis of Scaffold-free Prevascular Endothelial-Fibroblast Constructs. BMES 2017, Phoenix, Arizona, 2017. (abstract accepted; oral presentation in October 11-14) Pattanaik S, Bainbridge H, Rhett JM, Fann S, Yost M. Rapid Anastomosis and endothelial reorganization around scaffold-free, prevascular fibroblast-endothelial constructs. MSTP Research Day, Charleston, SC, September 2016 Pattanaik S, Bainbridge H, Rhett JM, Fann S, Yost M. Rapid Anastomosis of Scaffold-Free Endothelial-Fibroblast Constructs. Perry V. Halushka MUSC Research Day, Charleston SC, November 2016 Matthew Roberts (2016) Roberts MH, Shenker J. Non-Optic Vision: Beyond Synesthesia? MUSC MSTP Research Day. September 2016 Roberts MH, Shenker JI, Jhou T, Joseph J, Naselaris T. Non-Optic Vision: Beyond Synesthesia? Perry V. Halushka MUSC Research Day, Charleston SC, November 2016 Roberts, MH, Shenker JI, Joseph, J., Naselaris, T, & Jhou, T. Non-Optic Vision: Beyond Synesthesia. MUSC College of Medicine Research Day, Charleston, SC, 2016 Douglas Roberts-Wolfe (2011) Roberts-Wolfe D, Shields C, Gipson C, Scofield M, Kalivas P. Extinction Training Is Required For Transient Synaptic Potentiation In Accumbens Core And Shell. MUSC MSTP Research Day. September 2016 Roberts-Wolfe D, Shields C, Gipson C, Heinsbroek J, Bobadilla A, Kalivas P. Extinction training is required for transient synaptic potentiation in accumbens core and shell. Poster session presented at Society for Neuroscience, San Diego, CA, November 2016. Catherine Svetcharnik (2015) Svetcharnik CM, O’Neill CE, Newsom RJ, McGinty JF. Effects of Oxytocin Following Traumatic Stress on Methamphetamine Seeking in Female Rats. Poster. Perry V. Halushka MUSC Research Day, Charleston, SC, November 2016. Svetcharnik CM, O’Neill CE, Newsom RJ, McGinty JF. Effects of Oxytocin Following Traumatic Stress on Methamphetamine Seeking in Female Rats. Poster. MUSC 26th Annual MSTP Student Research Day, Charleston, SC, July 2016. Svetcharnik CM, Mlakar L, Wipf P, Feghali-Bostwick C. The Mechanism of Action of the Anti-fibrotic Drug MMS-350 Includes Activation of the Transcription Factor C-Ets-1. Poster. National MD/PhD Student Conference, Keystone, CO, July 2016.

Amer Toutonji (2016) Toutonji A. The Different Paths to Science & The Immune System in Stroke. Ashley Hall High School. June 16, 2016 Danh Tran (2014) Tran DT, Dong C, Alawieh A, Beeson G, Atkinson C, Nadig SN. Static Cold Storage Induces Metabolic Alterations and Autophagy in Models of Cardiac Transplantation. Abstract #1150. International Society of Heart & Lung Transplantation 37th Annual Meeting and Scientific Sessions, San Diego, CA, April 2017. Tran DT, Alawieh A, Beeson G, Atkinson C, Nadig SN. Rapamycin Reverses Metabolic Alterations Induced by Static Cold Preservation in Models of Transplantation. Abstract #119. American Society of Transplant Surgeon 17th Annual State of the Art Winter Symposium, Miami, FL, January 2017. Tran DT, Dong C, Alawieh A, Beeson G, Atkinson C, Nadig SN. Rapamycin Reverses Metabolic Alterations Induced by Static Cold Preservation in Models of Cardiac Transplantation. Abstract #139. Perry V. Haluska MUSC Research Day, Charleston, SC, November 2016. Tran DT, Dong C, Beeson G, Atkinson C, Nadig SN. Hypothermic Preservation Induces Mitochondrial Dysfunction and Metabolic Alteration in Models of Cardiac Transplantation. MUSC MSTP Research Day, Charleston, SC, July 2016. Jonathan Turner (2013) Turner JM, Woster PM, Davies C. Development Of Novel Penicillin Binding Protein 2 (PBP2) Inhibitors As Drug Candidates For Penicillin- And Cephalosporin-Resistant. Neisseria gonorrhoeae MUSC MSTP Research Day. September 2016 Turner JM, Woster PM, Davies C. Development of Novel Penicillin-binding Protein 2 (PBP2) Inhibitors as Drug Candidates for Penicillin- and Cephalosporin-Resistant Neisseria gonorrhoeae. Perry V. Halushka MUSC Research Day, Charleston, SC, November 2016. Turner JM, Randise J, Davies C. Identification of Penicillin-binding Protein 3 (PBP3) Inhibitors as Agents against Pseudomonas aeruginosa. Perry V. Halushka MUSC Research Day, Charleston, SC, November 2016. Turner JM, Woster PM, Davies C. Development of Novel Penicillin Binding Protein 2 (PBP2) Inhibitors as Drug Candidates for Penicillin- and Cephalosporin-Resistant Neisseria gonorrhoeae. Association for Clinical and Translational Research Conference, Washington DC, April 2017.

Shannon Weber (2015) Weber S, Alawieh A, Langley F, Tomlinson S. Targeted complement inhibition reduces chronic neuroinflammation and improves outcomes after murine traumatic brain injury. Perry V. Halushka MUSC Research Day, Charleston, SC, November 2016. Katelyn Williams (2012) Williams K, Lyu Z, Olsen S. Investigation of Cdc34 Molecular Interaction with Ubiquitin Conjugation Enzyme Partners. Perry V. Halushka MUSC Research Day, Charleston, SC, November 2016.

PUBLICATIONS Alawieh, A., Pierce, A. K., Vargas, J., Turk, A. S., Turner, R. D., Chaudry, M. I., &

Spiotta, A. M. (2017). The golden 35 min of stroke intervention with ADAPT: effect of thrombectomy procedural time in acute ischemic stroke on outcome. J Neurointerv Surg. doi:10.1136/neurintsurg-2017-013040

Alawieh, A., & Tomlinson, S. (2016). Injury site-specific targeting of complement inhibitors for treating stroke. Immunological Reviews, 274(1), 270-280. doi:10.1111/imr.12470

Alawieh, A., Wang, W., Narang, A., & Tomlinson, S. (2016). Thromboembolic model of cerebral ischemia and reperfusion in mice. Methods in Molecular Biology, 1462, 357-372. doi:10.1007/978-1-4939-3816-2_20

Alawieh, A., Zhao, J., & Feng, W. (2016). Factors affecting post-stroke motor recovery: Implications on neurotherapy after brain injury. Behavioural Brain Research. doi:10.1016/j.bbr.2016.08.029

Ren, C., Kobeissy, F., Alawieh, A., Li, N., Li, N., Zibara, K., . . . Mondello, S. (2016). Assessment of serum UCH-L1 and GFAP in acute stroke patients. Scientific Reports, 14(6). doi:10.1038/srep24588

Basher, F., Jeng, E. K., Wong, H., & Wu, J. (2016). Cooperative therapeutic anti-tumor effect of IL-15 agonist ALT-803 and co-targeting soluble NKG2D ligand sMIC. Oncotarget, 7(1), 814-830. doi:10.18632/oncotarget.6416

Bharani, K. L., Paller, K. A., Reber, P. J., Weintraub, S., Yanar, J., & Morrison, R. G. (2016). Compensatory processing during rule-based category learning in older adults. Aging, Neuropsychology, and Cognition, 23(3), 304-326. doi:10.1080/13825585.2015.1091438

Bonthius, D. J. (2016). The arenaviruses. Neurotropic Viral Infections: Volume 1: Neurotropic RNA Viruses, 149-174. doi:10.1007/978-3-319-33133-1_6

Carpenter, J. E., Clayton, A. C., Halling, K. C., Bonthius, D. J., Buckingham, E. M., Jackson, W., . . . Grose, C. (2016). Defensive perimeter in the central nervous system: Predominance of astrocytes and astrogliosis during recovery from varicella-zoster virus encephalitis. Journal of Virology, 90(1), 379-391. doi:10.1128/JVI.02389-15

Klein, H., Rabe, G. K., Karacay, B., & Bonthius, D. J. (2016). T-cells underlie some but not all of the cerebellar pathology in a neonatal rat model of congenital lymphocytic choriomeningitis virus infection. Journal of Neuropathology and Experimental Neurology, 75(11), 1031-1047. doi:10.1093/jnen/nlw079

Bowers, J. S., Nelson, M. H., Majchrzak, K., Bailey, S. R., Rohrer, B., Kaiser, A. D., . . . Paulos, C. M. (2017). Th17 cells are refractory to senescence and retain robust antitumor activity after long-term ex vivo expansion. JCI Insight, 2(5), e90772. doi:10.1172/jci.insight.90772

Majchrzak, K., Nelson, M. H., Bailey, S. R., Bowers, J. S., Yu, X. Z., Rubinstein, M. P., . . . Paulos, C. M. (2016). Exploiting IL-17-producing CD4+ and CD8+ T cells to improve cancer immunotherapy in the clinic. Cancer Immunol Immunother, 65(3), 247-259. doi:10.1007/s00262-016-1797-6

Nelson, M. H., Bowers, J. S., Bailey, S. R., Diven, M. A., Fugle, C. W., Kaiser, A. D., . . . Paulos, C. M. (2016). Toll-like receptor agonist therapy can profoundly augment

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Luciano, N. J., Sati, P., Nair, G., Guy, J. R., Ha, S. K., Absinta, M., ... & Reich, D. S. (2016). Utilizing 3D Printing Technology to Merge MRI with Histology: A Protocol for Brain Sectioning. Journal of visualized experiments: JoVE, (118).

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Kunal Patel, Carl Atkinson, Danh Tran, Satish N. Nadig. Nanotechnological Approaches to Immunosuppression and Tolerance Induction. Curr Transpl Rep. 2017 Jun; 4(2): 159-168

Tobiansky, D. J., Will, R. G., Lominac, K. D., Turner, J. M., Hattori, T., Krishnan, K., . . . Dominguez, J. M. (2016). Estradiol in the Preoptic Area Regulates the Dopaminergic Response to Cocaine in the Nucleus Accumbens. Neuropsychopharmacology, 41(7), 1897-1906. doi:10.1038/npp.2015.360

Whitaker, R. M., Corum, D., Beeson, C. C., & Schnellmann, R. G. (2016). Mitochondrial Biogenesis as a Pharmacological Target: A New Approach to Acute and Chronic Diseases. Annual Review of Pharmacology and Toxicology, 56, 229-249. doi:10.1146/annurev-pharmtox-010715-103155

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Ansa-Addo, E., Thaxton, J., Hong, F., Wu, B., Zhang, Y., Fugle, C.W., Metelli, A., Riesenberg, B., Williams, K., Gerwith, D., Chiosis, G., Liu, B., Li, Z. (2016). Clients and oncogenic roles of molecular chaperone gp96/grp94. Current Topics in Medicinal Chemistry, 16(25), 2765-2778.

Lv, Z., Rickman, K. A., Yuan, L., Williams, K., Selvam, S. P., Woosley, A. N., . . . Olsen, S. K. (2017). S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity. Mol Cell, 65(4), 699-714.e696. doi:10.1016/j.molcel.2017.01.008

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