medical scientist training program (mstp) annual...

Medical Scientist Training Program (MSTP)

Annual Report 2011-2012

College of Graduate Studies College of Medicine


MEDICAL SCIENTIST TRAINING PROGRAM COMMITTEE

Steering Committee 2011-2012

Dr. Perry V. Halushka, Director Professor of Pharmacology & Medicine Dean, College of Graduate Studies

Dr. Michael Kern Professor of Regenerative Medicine and Cell Biology

Dr. Robin Muise-Helmericks, Associate Director Assistant Professor of Regenerative Medicine and Cell Biology

Dr. Jim Oates Associate Professor of Medicine

Ms. Amy Connolly Assistant Director, MSTP

Dr. Shikhar Mehrotra Assistant Professor of Surgery

Dr. John M. Arthur Associate Professor of Medicine/Nephrology

Dr. Baerbel Rohrer Professor of Neurosciences

Dr. Maria G. Buse Professor of Medicine/Endocrinology

Dr. Cyntha Schandl Associate Professor of Pathology & Laboratory Medicine

Dr. James A. Cook Professor of Neurosciences

Dr. Rick Schnellmann Professor & Chair of Pharmaceutical Sciences

Dr. Deborah Deas Senior Associate Dean for Medical Education, College of Medicine Professor, Psychiatry & Behavioral Medicine

Dr. Joann Sullivan Assistant Dean for Extramural Program Development

Dr. Maurizio Del Poeta Professor of Biochemistry & Molecular Biology

Dr. Stephen Tomlinson Professor of Microbiology & Immunology

Dr. Scott Eblen Assistant Professor of Cell & Molecular Pharmacology


MEDICAL SCIENTIST TRAINING PROGRAM COMMITTEES

2011-2012 Progress Committee Dr. Perry Halushka Dr. Robin Muise-Helmericks

Scholarship Committee Dr. Perry Halushka Dr. Robin Muise-Helmericks

Recruitment Committee Dr. Perry Halushka Dr. Maria Buse Dr. James Cook Dr. Scott Eblen Dr. Victoria Findlay Dr. Elizabeth Garrett-Mayer Dr. Michael Janech Dr. Michael Kern Dr. Yiannis Koutalos Dr. Amanda LaRue Dr. Shikrha Mehrotra Dr. Robin Muise-Helmericks Dr. Carola Neumann Dr. Jim Oates Dr. Baerbel Rohrer Dr. Cynthia Schandl Dr. Ron See Mr. Brandon Bentzley Mr. Benjamin Newcomb Mr. Lee Wheless Mr. Ryan Whitaker Dr. Cynthia Wright – Ex-officio Dr. Deborah Deas – Ex-officio Ms. Joan Graesch – Ex-officio

Seminar Committee Mr. Joseph Cheng Mr. Mohamad Dahrouj Representative to Graduate Council Mr. Anthony Leonard


MEDICAL SCIENTIST TRAINING PROGRAM STUDENTS

MSTP Matriculation Students Date Advisor Undergraduate School Mohamad Adada 06/11 Dr. R. Young American University of Beirut Adnan Al-Ayoubi 8/05 Dr. S. Eblen American University of Beirut Joseph Alge 06/10 Dr. J. Arthur Wofford University/MUSC Obaidallah Aseem 6/06 Dr. S. Argraves Morehouse College DeAnna Baker 8/04 Dr. G. Gilkeson University of Maryland-Baltimore County Tiffany Baker 6/09 Dr. L. Cunningham College of Charleston/MUSC Fahmin Basher 6/08 Dr. T. Nowling University of South Carolina Thomas Beckham 6/07 Dr. J. Norris Clemson University Brandon Bentzley 6/09 Dr. G. Aston-Jones College of New Jersey-Trenton Jennifer Blakely 6/07 Dr. C. Beeson Erskine College Jacob Bowers 6/11 Dr. T. Nowling University of Utah Sarah Brice 6/10 Dr. A. Cowart Clemson University/MUSC Laura Briggs 7/08 Dr. A. Wessels University of Florida Robert Cameron 05/11 Dr. C. Beeson Davidson College Joseph Cheng 6/05 Dr. J. Norris Dartmouth College Danielle Clark 6/09 Drs. I. Singh/D. Jenkins Marshall University Mohammad Dahrouj 6/10 Dr. C. Crosson American University of Beirut Anna-Maria De Costa 6/06 Dr. M. R. Young Wofford University Andre Eaddy 7/04 Dr. R. Schnellmann Morehouse College Christopher Gault 7/03 Dr. L. Obeid University of California-Santa Barbara George Russell Glenn 8/10 Dr. A. Tabesh Wofford University George Daniel Grass 7/08 Dr. B. Toole Charleston Southern University David Hartmann 7/12 Dr. L. J. Chandler New College of Florida Linda Heffernan 8/04 Dr. L. Obeid George Washington University Daniel Herr 6/11 Dr. L. Obeid University of Scranton Russell Jenkins 7/04 Dr. Y. Hannun University of Virginia Christopher B Johnson 6/09 Dr. D. Cole University of North Carolina-Chapel Hill Craig Kutz 6/10 Dr. S. Kubalak Minnesota State University Moorhead Anthony Leonard 1/07 Dr. B. Rohrer Emory & Henry Sarah Tucker Marrison 6/08 Dr. J. Norris Yale University Ahmad Mashmoushi 7/07 Dr. J. Oates American University of Beirut Jamie Mills 6/11 Dr. V. Findlay California State University-Chico Keely Morris 6/06 Dr. S. Tomlinson Cal Tech Khaled Moussawi 8/05 Dr. P. Kalivas American University of Beirut Thomas Mullen 6/03 Dr. L. Obeid Clemson University Daniel Neitzke 6/10 Dr. M. George University of Virginia Benjamin Newcomb 6/09 Dr. Y. Hannun Seattle University Ken Noguchi 5/12 Dr. P. Howe Kenyon College Casey O’Dell 6/10 Dr. N. Banik Erskine University Armina Omole 7/05 Dr. P. Kalivas University of Maryland Baltimore County Joseph Palatinus 6/05 Dr. R. Gourdie Davidson College

David Perry 6/06 Dr. Y. Hannun Clemson University Saleh Rachidi 6/10 Dr. Z. Li American University of Beirut Ryan Rhome 7/04 Dr. M. Del Poeta University of Georgia Douglas Roberts-Wolfe 6/11 Dr. G. Aston-Jones Hampshire College Sahar Saddoughi 6/07 Dr. B. Ogretmen Barnard College Jennifer Scott 8/09 Dr. G. Gilkeson University of Central Florida Achraf Shamseddine 6/11 Dr. C. Voelkel-Johnson American University of Beirut Amena Smith 6/05 Dr. N. Banik Lee College Joshua Smith 6/08 Dr. N. Banik Wofford College Adrian Sproul 7/03 Dr. P. D. Bell Oberlin College Kyle Strickland 6/05 Dr. S. Krupenko College of Charleston Erik Strungs 6/09 Drs. R. Gourdie/ University of Minnesota-Twin Cities L. Luttrell Alton Sutter 6/07 Dr. K. Chavin College of Charleston Peter Tang 6/06 Dr. R. Crouch University of Pennsylvania Joseph Taylor 6/07 Dr. M. George Davidson College Abigail Washispack 6/12 Dr. J. Jones University of Arkansas Ft. Smith Rebecca Weber 6/08 Dr. M. Wargovich Denison University Lee Wheless 6/05 Dr. A. Alberg Davidson College Ryan Whitaker 6/08 Dr. R. Schnellmann University of Iowa Katelyn Williams 6/12 Dr. B. Ogretmen University of Maryland Baltimore County Parker C. Wilson 6/05 Drs. L. Luttrell Johns Hopkins University Xiaoyi Zhang 6/08 Dr. K. Kirkwood University of South Carolina

MSTP Graduates (1982-2011)

MSTP Graduate Date Residency Current Position Samuel E. Gandy, III, MD, PhD

1982 Cornell University

Mt. Sinai Professor Alzheimer’s Research, Professor of Neurology & Psychiatry. Mt. Sinai Medical School

Geoffrey E. Renk, MD, PhD

1986 UCLA Emergency Medicine, Mt. Pleasant, SC

Robert P. Aftring, MD, PhD 1987 Beth Israel Group Director, Clinical Cardiovascular and Metabolic Medicine Development Center, Glaxo-Smith Kline and French

Charles F. Burant, MD, PhD

1987 University of California San Francisco

Professor of Medicine, Professor of Molecular Integrative Physiology, Robert C. & Veronica Atkins Professor of Metabolism, University of Michigan

Kevin D. Ballard, MD, PhD* 1989 Baylor College of Medicine

Director of Research and Development, National Medical Services Labs, Willow Grove PA

Richard L. Griffith, MD, PhD

1989 University of Virginia Hospital

Practice in Internal Medicine/Immunology, Marietta, GA

Stanley A. Katz, MD, PhD 1989 Vanderbilt University

unknown

Margaret O. Sowell, MD, PhD

1990 Brigham and Women's Hospital

Global Clinical Safety and Pharmacovigilance, GlaxoSmithKline

Richard H. Peters, MD, PhD

1991 Massachusetts General Hospital

Vice President, Head of Global Medical Affairs, Sanofi Oncology

N. Carolyn Schanen, MD, PhD

1991 Stanford University

Adjunct Associate Professor, Biological Sciences, University of Delaware/Head, Human Genetics Research, A.I. duPont Hospital for Children

Keith A. Coffee, MD, PhD 1992 Vanderbilt University

Senior Medical Director, Global Therapeutic Development, Pharmaceutical Product Development, Inc.

Stephen R. Murray, MD, PhD

1992 University of California San Francisco

Senior Medical Officer, TB Alliance, New York, NY

Jeffery L. Twiss, MD, PhD 1992 Stanford University

Professor & Department Head, Department of Biology, Drexel University

William Oehlenschlager, MD, PhD

1993 Case Western Reserve University

WRH Health System, Wadsworth OH

C. Richard Ross, MD, PhD 1993 Johns Hopkins University

Practice in Emergency Medicine, Modesto, CA

Kendrick A. Shunk, MD, PhD

1993 University of Chicago

Associate Professor of Medicine, Director Cardiac Catheter Lab, UCSF

Charles J. Beischel, MD, PhD

1994 Medical University of South Carolina

Clinical Assistant Professor of Ophthalmology, MUSC

J. Bryan Hill, MD, PhD 1995 Baylor University Private Practice, Anderson SC

Charles T. Ivester, MD, PhD

1996 University of Utah

Practice in Internal Medicine, Pulmonary Medicine, Salt Lake City, UT

Timothy C. Ball, MD, PhD 1997 Bowman Gray Assistant Professor, Internal Medicine, Virginia Tech Carilion School of Medicine/Interventional Cardiologist, Carilion Clinic, Roanoke, VA

Bradley S. Miller, MD, PhD 1997 Mayo Clinic Associate Professor of Pediatrics, Division of Pediatric Endocrinology, University of Minnesota

Kimberly V. Barnes, MD, PhD


Private Practice, Chicago IL

Gloria J. Bullock Morris, MD, PhD

1998 Thomas Jefferson University

Assistant Professor of Medicine, Department of Oncology, Mt. Sinai School of Medicine, Tisch Cancer Institute

Charles E. Hill, MD, PhD 1998 Emory University Assistant Professor of Pathology & Laboratory Medicine, Director Molecular Diagnosis, Emory University

Ana Maria Ibrado, MD, PhD

1998 Johns Hopkins University

Practice in Emergency Medicine Providence Hospital, Washington, DC

John H. Cleator, MD, PhD 1999 Cleveland Clinic Assistant Professor of Medicine, Cardiology Division Director of the Experimental Angiographic Laboratory, Vanderbilt University

Michel A. Makhlouf, MD, PhD

1999 University of Pittsburgh Magee Women's Hospital

Assistant Professor, OB/GYN, University of Texas, Galveston

Cynthia A. Schandl, MD, PhD

1999 Medical Univ. of South Carolina

Associate Professor, Department of Pathology, MUSC

Keith T. Borg, MD, PhD 2000 University of Cincinnati

Associate Professor, Emergency Medicine/Division Chief, Pediatric Emergency, MUSC

Justin P. Favaro, MD, PhD 2000 University of Texas, Dallas Southwestern Medical Center

Assistant Consulting Professor, Department of Medicine, Duke University/Private Practice Hematology Oncology

Kim M. Huffman, MD, PhD 2000 Duke University Assistant Professor of Medicine, Division of Rheumatology, Duke University Medical Center Staff Physician, Physical Medicine & Rehabilitation, Durham VA Medical Center

Antoine A. Makhlouf, MD, PhD

2000 University of Virginia

Private Practice, Urology, Sugar Land, TX

Donald C. Shields, MD, PhD

2000 UCLA Assistant Professor of Neurosurgery, George Washington University Medical Center

Kristie B. Blade, MD, PhD 2001 University of Washington

Virginia Mason Medical Center (last known position)

Mark (Horney) Jameson, MD, PhD


Assistant Professor of Otolaryngology, University of Virginia

Chad E. Hudson, MD, PhD 2001 University of Maryland

Private Practice OB/GYN, Hagerstown, MD

Deanne L. King, MD, PhD 2002 University of Arkansas

Resident in Otolaryngology, University of Arkansas

Richard A. Walgren, MD, PhD

2002 Washington University

Senior Medical Advisor for Oncology, Eli Lilly, Indianapolis, IN

Joseph R. Kelley, MD, PhD 2003 Medical College of Virginia

Private Practice in Radiation Oncology, Wichita, Kansas

Stewart M. Knoepp, MD, PhD

2003 Massachusetts General Hospital/Harvard

Assistant Professor of Pathology, University of Michigan

Bryce A. Nelson, MD, PhD 2003 Vanderbilt University

Pediatric Endocrinology, Greenville, SC

Christopher D. Willey, MD, PhD

2003 Vanderbilt University

Assistant Professor of Radiation Oncology, Univ. of Alabama, Birmingham

Scott P. Commins, MD, PhD


Assistant Professor of Medicine, Asthma & Allergic Diseases Center, University of Virginia

Christopher A. Wells, MD, PhD


Research Instructor, Cardiovascular Medicine, Vanderbilt University

Ralph J. Barker, MD, PhD 2005 MUSC/Surgery Resident 2005 MUSC Surgical Critical Care Fellowship, MUSC

Kevin Becker, MD, PhD 2005 Yale Assistant Professor, Neurology, Division of Medical Neuro-oncology, Yale University

Michael L. Bernard, MD, PhD 2005 Vanderbilt University/Internal Medicine Resident


Fellow, Electrophysiology Cardiology, MUSC

Christopher V. Crosby, MD, PhD

2005 Emory University Clinical Assistant Professor, Dermatology, University of California San Diego

Michelle B. Crosby, MD, PhD

2005 Emory University Clinical Assistant Professor, Ophthalmology, University of California San Diego

Ron J. Feldman, MD, PhD 2005 Cleveland Clinic Assistant Professor, Dermatology, Emory University

Joshua M. Hubbard, MD, PhD


Asheville Radiology, Asheville, NC

Benjamin J. Pettus, MD, PhD

2005 Washington University, St. Louis

Private Practice, Radiology, Yorktown, VA

Vijay U. Rao, MD, PhD 2005 Duke University Cardiology, St. Francis Medical Group, Indianapolis, IN

Nicole Redmond, MD, PhD 2005 Emory University Assistant Professor, Preventive Medicine, University of Alabama-Birmingham

Stephen F. Shafizadeh, MD, PhD


Infolded Fellowship in Cerebrovascular and Skull Base Surgery, University of Chicago

Justin Turner, MD, PhD 2006 Johns Hopkins Fellow, Endoscopic Sinus & Skull Base Surgery, Stanford University

John Yordy, MD, PhD 2006 MD Anderson Assistant Professor, Radiation Oncology, University of Texas Southwestern

Zachary Bowman MD, PhD 2007 UCSD Maternal/Fetal Medicine Fellow, University of Utah Health Sciences

Lena Heung, MD, PhD 2007 Baystate/Tufts Affiliate

Fellow, Infectious Diseases, University of Washington

Shantae Jenkins, MD, PhD 2007 MUSC Hospitalist, Colleton Medical Center

Eric Sribnick, MD, PhD 2007 Emory University Resident, Neurosurgery, Emory University

Tarek Taha, MD, PhD 2007 Indiana University

Fellow, Orthopedic Trauma Surgery, Scottsdale, Arizona

David Arrington, MD, PhD 2008 Georgetown University/MUSC

Fellow, Body Imaging, University of Alabama Birmingham

Mary Lee Gregory, MD, PhD

2008 Baystate/Tufts Affiliate

Resident, Pediatric Neurology and Neurodevelopmental Medicine, Johns Hopkins Kennedy-Krieger Institute

Gregor Krings, MD, PhD 2008 Mass. General Hospital/UCSF

Research Fellow, Pathology, UCSF

John Shea, MD, PhD 2008 Allegheny General

Resident, Emergency Medicine, Allegheny General

Laura Spruill, MD, PhD 2008 MUSC Fellow, Surgical Pathology, MUSC

Brice Williams, MD, PhD 2008 University of Utah

Resident Ophthalmology, University of Utah

Saeed ElOjeimy, MD, PhD 2009 University of Washington

Resident, Diagnostic Radiology, University of Washington

Amanda Galloway, MD, PhD

2009 University of Texas Southwestern-Dallas

Resident, Pediatrics, University of Texas-Southwestern

Jason Guichard, MD, PhD 2009 University of Alabama-Birmingham

Resident, American Board of Internal Medicine Research Pathway, University of Alabama Birmingham

Mark Hallman, MD, PhD 2009 MUSC/Fox Chase Cancer Center

Resident, Radiation Oncology, Fox Chase Cancer Center

Youssef Zeidan, MD, PhD 2009 Stanford University

Resident, Radiation Oncology, Stanford

Rany Abdallah, MD, PhD 2010 MUSC/ Lenox Hill/Rush

Resident, Anesthesiology, Rush University Medical Center

Jamie Fraser, MD, PhD 2010 National Institutes of Health

Resident, Pediatric Genetics

Mona Taleb, MD, PhD 2010 Mt. Sinai Medical Center-Miami/ Wayne State

Resident, Surgery, Wayne State

Juan Varela, MD, PhD 2010 Johns Hopkins University

Resident, Internal Medicine, Johns Hopkins University

Jonathan Butler, MD, PhD 2011 Vanderbilt Resident, Adult Neurology, Vanderbilt

Justin Ellett, MD, PhD 2011 MUSC Resident, Surgery/Urology, MUSC

Loretta Jophlin, MD, PhD 2011 Mt. Sinai Resident, Internal Medicine, Mt. Sinai

Jason Lockrow, MD, PhD 2011 University of Washington

Resident, Pediatric Neurology, University of Washington

Phillip Moschella, MD, PhD 2011 University of Cincinnati

Resident, Emergency Medicine, University of Cincinnati

Michael O’Quinn, MD, PhD 2011 MUSC/VCU Resident, Internal Medicine, Virginia Commonwealth University

Brian Snarr, MD, PhD 2011 University of Texas-Southwestern

Resident, Pediatrics, University of Texas-Southwestern

Jarrett Walsh, MD, PhD 2011 University of Iowa

Resident, Otolaryngology, University of Iowa

Adnan Al-Ayoubi, MD, PhD 2012 MUSC Intern, General Surgery, MUSC

DeAnna Baker, MD, PhD 2012 Duke Resident, Internal Medicine, Duke University

Christopher Gault, MD, PhD

2012 University of Pennsylvania

Resident, Pathology, University of Pennsylvania

Linda Heffernan-Stroud, MD, PhD

2012 Eastern Virginia Medical Center

Intern, Internal Medicine Greenville Memorial/Resident, Dermatology, Eastern Virginia Medical Center

Russell Jenkins, MD, PhD 2012 Mass General Intern, Internal Medicine, Massachusetts General Hospital

Khaled Moussawi, MD, PhD

2012 Mass General Intern, Internal Medicine/Resident, Neurology, Brigham & Women’s

Thomas Mullen, MD, PhD 2012 Tufts/University of Washington

Intern, Lemuel Shattuck Hospital/Resident, Radiation Oncology, University of Washington

Ryan Rhome, MD, PhD 2012 MUSC/Mt. Sinai Intern, Internal Medicine, MUSC/Resident, Radiation Oncology, Mt. Sinai Hospital

Adrian Sproul, MD, PhD 2012 MUSC/UNC Chapel Hill

Intern, Transitional Surgery, MUSC/ Resident, Anesthesia, UNC Chapel Hill

*Deceased

HIGHLIGHTS (2011-2012) The national prominence of the program continues to increase significantly. This year, we had 174 applications, the highest number in the history of the program. Last year we had 164 applications. The quality of the applicant pool remains very high. We interviewed a total of 55 applicants. The average GPA and MCAT scores of the interviewees were 3.75 and 33.84, respectively. We had a total of 4 new students matriculate. Their GPA and MCAT scores were 3.76 and 34.25, respectively. Of particular note, is the extensive undergraduate research experiences that the applicants had. It was clear during the recruitment process that we continue to compete with the best programs in the country. David Hartmann and Abigail Washispack, incoming first year students, were both awarded the annual MUSC Physicians/MSTP scholarship. David Hartmann was also awarded the Lane scholarship and the Suzann Pershing Award. Anna-Maria De Costa was awarded an SCE&G scholarship. From the Hollings Cancer Center, Daniel Neitzke and Katelyn Williams received the Abney scholarship. The seven students who were awarded NIH predoctoral fellowships from the training grant are Robert Cameron, Joseph Cheng, G. Daniel Grass, Daniel Herr, Jamie Mills, Ken Noguchi and Lee Wheless. Congratulations to Sarah Brice Russo and Joe Taylor who received Ruth Kirschstein NSRA fellowships. Our success rate for obtaining these NRSA fellowships is approximately twice the national average, which is 30%. Our new students and their undergraduate institutions are listed below.

David Hartmann New College of Florida Ken Noguchi Kenyon College Abigail Washispack University of Arkansas Fort Smith Katelyn Williams University of Maryland Baltimore County

This year we graduated nine students. Institution Field of Study Adnan Al-Ayoubi MUSC General Surgery DeAnna Baker Duke University Internal Medicine Chris Gault University of Pennsylvania Pathology Linda Heffernan-Stroud Greenville Memorial Internal Medicine Eastern Virginia Medical Ctr Dermatology Russ Jenkins Massachusetts General Internal Medicine Khaled Moussawi Massachusetts General Internal Medicine Brigham & Women’s Neurology Tom Mullen Lemuel Shattuck Hospital Transitional Year University of Washington Radiation Oncology Ryan Rhome MUSC Internal Medicine Mt. Sinai Radiation Oncology Adrian Sproul MUSC Transitional Surgery

UNC-Chapel Hill Anesthesia

Russell Jenkins and Khaled Moussawi were named as co-recipients of the Distinguished Graduate of the Year Award. This was unprecedented as the Award Committee deemed both students’ accomplishments outstanding and could not distinguish between them. They will both return in August to present the Liz Chesterman Memorial lecture to the incoming graduate students. The monthly student seminar series, which are organized by the students, continues to be very successful. It is scheduled for the fourth Monday of each month at 5:00 p.m. Faculty from our institution presented informal research seminars at each of the meetings. These interactions have resulted in several students choosing the presenters as mentors for research projects. This year, three students who were ready to defend their dissertation presented their research. This provided an excellent venue for them to practice their presentation. It also allowed the other students in the program to learn about their colleague’s research.

10/10/11 Kyle Strickland 2/27/12 Sahar Saddoughi 5/21/12 G. Daniel Grass

Our Translational Medicine Seminar series has been a great success. Each one of our senior students paired with one of our faculty to present a clinical case. This was followed by a research discussion by the faculty member focused on the disease that was presented. The topics and speakers are listed below: 7/11/11 DeAnna Baker with Gary Gilkeson, MD

Advances in the Systemic Lupus Erythematosus 8/8/11 Russell Jenkins with John Lazarchick, MD and Keisuke Shirai, MD

Hemophagocytic Lymphohistiocytosis: A Rare, but Often Fatal Non-Malignant Systemic Inflammatory Condition - Case Review, Diagnosis, Treatment, and Current Investigations

9/26/11 Chris Gault with Milos Budisavljevic, MD TTP And Plasma Exchange; From Clinic To Bench And Back To Clinic

1/9/12 Adrian Sproul with Francis McGowan, MD Single Ventricle Physiology In Adults Following Staged Repair Of Congenital Heart Disease

2/13/12 Linda Heffernan-Stroud with Keith Borg, MD, PhD Traumatic Brain Injury - Challenges in Translation

3/12/12 Khaled Moussawi with Leonardo Bonilha, MD, PhD The Quest for Understanding Epilepsy Through Neuroimaging

4/9/12 Ryan Rhome with Ernest Camp, MD, MSCR Targeting EMT to Enhance Therapy of Colon Cancer

The Translational Sciences Clinics have proven to be a very rewarding and successful experience for our students. Both the students and faculty have provided very positive evaluations.

During this past year eleven students; Joseph Cheng, Anna-Maria De Costa, Andre Eaddy, G. Daniel Grass, Joseph Palatinus, David Perry, Sahar Saddoughi, Amena Smith, Kyle Strickland, Lee Wheless and Parker Wilson successfully defended their Ph.D. dissertations. Our 22nd Annual MSTP Student Research Day was held on March 24, 2012 in the Bioengineering Building. There were 10 oral, 27 poster presentations as well as 4 Clinical and Translational Research Center presentations. All of the presentations reflected the high quality science that our students are conducting. One of our alumni, Scott Commins, M.D., Ph.D., Assistant Professor of Medicine and Pediatrics at the University of Virginia, was the keynote speaker. The title of his talk was “Delayed Anaphylaxis to Mammalian Meat: How Oncologists Helped Discover a Novel Food Allergy.” This has also been an exciting year for many of our students. Jennifer Blakeley became engaged to Joey Harmon, Danielle Clark became engaged to Charlie Lowe and Alton Sutter became engaged to Alina Ovechkina, Anthony Leonard and Emily Bowen were married in October, Erik Strungs and Amanda Zimmerman were married in November, Andre Eaddy and Nicole Rogers were married in May and Sarah Brice and Adam Russo were also married in May. Joey and Mikah Alge had a baby girl, Eleanor, on March 2 and Anna-Maria and Brian De Costa had a baby boy, Benjamin, on June 8.

Sarah Brice & Adam Russo Andre Eaddy & Nicole Rogers (and Ben) (Deontae, Myles and Madison)

Casey O’Dell & Joshua Holmes Anthony Leonard & Emily Bowen

Erik Strungs & Amanda Zimmerman

Eleanor Lynn Alge Benjamin Augustus De Costa

Our students continue to garner many honors and awards that you will see listed after their names. Including the incoming class, we currently have 53 students in the program. GOALS FOR 2012-2013

• We will continue to try to identify philanthropic support for the program • We will re-evaluate our recruitment and admissions process • Increase the size and quality of our applicant pool • Formally evaluate the program via the instrument developed at the time of the

submission of the grant • Replace the program director

AWARDS AND HONORS (2011-2012) Listed below are the many honors and awards our students have garnered during the past year. Student’s Name (Year of Matriculation) Joseph Alge (2010) American Society of Nephrology 2011 Kidney Week Travel Award 2011 Tiffany Baker (2009) Ruth L. Kirchstein National Research Service Award F30 2011 Fahmin Basher (2008) Travel Award American College of Rheumatology Research Workshop 2012 Thomas Beckham (2007) MUSC College of Medicine’s Most Outstanding Student Volunteer 2012 Brandon Bentzley (2009) NIH/MSTP Predoctoral Fellowship Training Grant, GM08716 2011-2012 American Society for Clinical Pathology Award for Academic Excellence and Achievement 2011-2012 Jennifer Blakely (2007) Ruth L. Kirchstein National Research Service Award F30 DK091107 2011-2012 Jacob Bowers (2011) Desiree Roy Research Scholarship 2012 NIH/MSTP Predoctoral Fellowship Training Grant, GM08716 2011-2012 Laura Briggs (2008) Travel Award to 2012 Weinstein Conference 2012 Robert Cameron (2011) Lane Family Scholarship 2011 University Medical Associates/MSTP Scholar 2011-2012 Mohammad Dahrouj (2010) Travel Award ARVO Foundation/Retina Research Foundation/Joseph M. and Eula C. Lawrence 2012 Danielle Desjardins (2011) SCTR TL1 Trainee 2011-2012

Chris Gault (2003) Ruth L. Kirchstein National Research Service Award F30 HL093991-01A1 2011-2012 George Russell Glenn (2010) NIH/MSTP Predoctoral Fellowship Training Grant, GM08716 2011-2012 George Daniel Grass (2008) Travel Award for ASCI (American Society for Clinical Investigation), AAP (Association of American Physicians) Joint Meeting 2012 Regulation of Invadopodia Formation and Activity by CD147. J Cell Science; 125(Part3): 777-788, 2012. Paper was reviewed by a member of the faculty of 100 which places the work in a library of the top 2% of published articles in biology and medicine 2012 1st Place, PhD Poster III Category, The Perry V. Halushka MUSC Student Research Day 2011 DOD Breast Cancer Research Program Predoctoral Traineeship W81XWH-10-1-0083 2011-2012 Presidential Scholar 2011-2012 Linda Heffernan-Stroud (2004) Ruth L. Kirschstein National Research Service Award, F30ES017379 2011-2012 Daniel Herr (2011) University Medical Associates/MSTP Scholar 2011-2012 Casey O’Dell Holmes (2010) NIH/MSTP Predoctoral Fellowship Training Grant, GM08716 2011-2012 Russell Jenkins (2004) South Carolina Electric & Gas Scholarship 2011-2012 MUSC College of Graduate Studies Distinguished Graduate Student Award 2012 Christopher Bryce Johnson (2009) MUSC Hollings Cancer Center Abney Foundation Scholarship 2011-2012 Anthony Leonard (2008) Travel Award, 26th Annual National MD/PhD Student Conference 2011 Jamie Mills (2010) Lane Family Scholarship 2011 Keely Morris (2006) Ruth L. Kirchstein National Research Service Award F30 DK089696-01 2011-2012

Khaled Moussawi (2005) Alpha Omega Alpha Medical Society 2011 MUSC College of Graduate Studies Distinguished Graduate Student Award 2012 Thomas Mullen (2003) Ruth L. Kirchstein National Research Service Award F30 2011-2012 Alpha Omega Alpha Medical Society 2011 MUSC College of Graduate Studies Distinguished Graduate Student Finalist 2012 Daniel Neitzke (2010) NIH/MSTP Predoctoral Fellowship Training Grant, GM08716 2011-2012 Benjamin Newcomb (2009) MUSC Hollings Cancer Center Abney Foundation Scholarship 2011-2012 Joseph Palatinus (2005) Ruth L. Kirschstein National Research Service Award, 1F30HL095320-01 2011-2012 Saleh Rachidi (2010) Award from South Carolina Clinical and Translational Research Institute (SCTR) for inflammatory genes in cancer 2012 Ryan Rhome (2004) MUSC Student Leadership Award 2012 Douglas Roberts-Wolfe (2011) Suzann Pershing Scholarship 2011-2012 NIH/MSTP Predoctoral Fellowship Training Grant, GM08716 2011-2012 Sarah Brice Russo (2010) Ralph H. Johnson VAMC Student Research Honorable Mention Certificate, PhD Oral VI Category, The Perry V. Halushka MUSC Student Research Day 2011 Ruth L. Kirchstein National Research Service Award F30 DK09125 2011-2012 Presidential Scholar 2011-2012 Sahar Saddoughi (2006) Ruth L. Kirschstein National Research Service Award, F30 2011-2012 Amena Smith (2005) Ruth L. Kirschstein National Research service Award F31EY019457-01 2011-2012 Joshua Smith (2008) 2nd Place, PhD Oral VI Category, The Perry V. Halushka MUSC Student Research Day 2011

Kyle Strickland (2005) Sigma Xi Award, MUSC Student Research Day 2011 2nd Place, Ph.D. Oral VII Category, The Perry V. Halushka MUSC Student Research Day 2011 Ruth L. Kirschstein National Research Service Award 1F30DK083215-01A2 2011-2012 Erik Strungs (2009) SCTR TL1 Trainee 2011-2012 Peter Tang (2006) 1st place, Clinical-Professional-Masters Oral VI Category, The Perry V. Halushka MUSC Student Research Day 2011 NIH/MSTP Predoctoral Fellowship Training Grant, GM08716 2011-2012 Joseph Taylor (2007) Student Research Honorable Mention, Ralph H. Johnson VAMC 2011 Women’s Club Scholarship, Medical University of South Carolina 2011 Howard Hughes Medical Institute Teacher Training Fellowship, College of Charleston 2011 MUSC, College of Graduate Studies Most Outstanding Student Volunteer 2012 Selected for NINDS/AUPN Combining Clinical/Research Careers in Neuroscience Symposium 2012 1st Place Poster Presentation, 13th Annual Frontiers in Neuroscience Research Day 2012 NIDA NRSA F30 Fellowship Award, National Institutes of Health, NIDA 1F30DA033748-01 2012 Penn Fellowship in Neuroscience & Society, University of Pennsylvania 2012 American Neuropsychiatric Association (ANPA) Young Investigator Award 2012 Lee Wheless (2005) Society for Investigative Dermatology PhD Retreat Invited Attendee 2012 Xiaoyi Tina Zhang (2008) 2nd place, PhD IV Oral Category, The Perry V. Halushka MUSC Student Research Day 2011 American Medical Association Foundation Seed Grant Recipient 2012

PUBLICATIONS Our students have also been very productive in their research endeavors, as witnessed by their publication records. In 2011-2012 they authored or co-authored 60 manuscripts that have been published or are in press and an additional 15 manuscripts have been submitted. Three book chapters have been published and 2 in preparation (compared to 1 last year) and they submitted 110 abstracts for presentation compared to 102 last year.

Adnan Al-Ayoubi (2005) Abstracts: Al-Ayoubi AM, Zheng H, Liu Y, Bai T, Eblen ST. ERK2 Phosphorylation of Splicing Factor 45 (SPF45) Regulates SPF45 Alternative Splicing Site Utilization and Downstream Gene Expression. The Perry V. Halushka MUSC Student Research Day. Charleston, SC. November 2011 Liu Y, Al-Ayoubi A, Zheng H, Bethard J, Eblen ST. The SR Protein Kinase Clk1 Phosphorylates SPF45 and Regulates Its Degradation and Splice-Site Selectivity. The Perry V. Halushka MUSC Student Research Day. Charleston, SC. November 2011

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In Press

Joseph Alge (2010) Abstracts: Alge J, Chawla LS, Tumlin JA, Arthur JM. The Ratio of alpha-1-Acid Glycoprotein to alpha-1B Glycoprotein in Urine Is an Early and Accurate Predictor of Acute Kidney Injury [Abstract]. J Am Soc Nephrol 22, 2011: 358A. Alge JL, Janech MG, Shaw AD, Chawla LS, Tumlin JA, Arthur JM. The Ratio of Alpha-1B-Glycoprotein to Zinc Alpha-2 Glycoprotein in Urine Is an Early and Accurate Predictor of Acute Kidney Injury. The Perry V. Halushka MUSC Student Research Day. Charleston, SC. November 2011 Alge JL Janech MG, Shaw AD, Chawla LS, Tumlin JA, Arthur JM. Urinary Angiotensinogen Predicts Acute Kidney Injury After Cardiac Surgery. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Obaidullah Aseem (2006) Abstracts: Aseem O, Smith BT, Cooley MA, Argraves WS. Cubilin is Essential for Maintaining Blood HDL Levels, The Perry V. Halushka MUSC Student Research Day. Charleston, SC. November 2011 Aseem O, Smith BT, Cooley MA, Argraves WS. The Epigenetic Regulation of Multi-Ligand Receptor Cubilin. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 DeAnna Baker (2004) Manuscripts: Baker, DA, Obeid LM, Gilkeson GS. Impact of sphingosine kinase on inflammatory pathways in fibroblast-like synoviocytes. Inflamm Allergy Drug Targets. 2011 Dec 1;10(6):464-71 Abstracts: Hunter DA, Baker DA, Gray J, Gonsalves W. Point of Care Testing for Diabetic Patients in the Student Run Free Clinic: Advantages for the Patients, Students, and Your Bottom Line. Society for Student Run Free Clinics Annual Meeting, Houston, TX January 2011 Tiffany Baker (2009) Manuscripts: Bullard SA, Baker T, de Buron I. New species of Cardicola (Digenea: Aporocotylidae) from heart of Atlantic Croaker, Micropogonias undulatus (Perciformes: Sciaenidae), of the South Atlantic Bight. Journal of Parasitology 98(2):328-332 Fahmin Basher (2008) Abstract: Basher F, Amani A, Bunni M, Nowling T. Effects of Fli1 on T Cell Function in Systemic Lupus Erythematosus. MUSC MSTP Research Day, Charleston, SC, March 24, 2012

Thomas Beckham (2007) Manuscripts: Turner LS, Cheng JC, Beckham TH, Keane TE, Norris JS, Liu X. Autophagy is increased in prostate cancer cells overexpressing acid ceramidase and enhances resistance to C6 ceramide. Prostate Cancer and Prostatic Diseases. 2011; 14, 30-37 Beckham TH, Lu P, Cheng JC, Zhao D, Turner LS, Zhang X, Hoffman S, Armeson KE, Liu A, Marrison T, Hannun YA, and Liu X. Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through up-regulation of cathepsin B. Int J Cancer. 2012 PMID: 22322590 Beckham TH, Cheng JC, Marrison ST, Norris JS, Liu X. Interdiction of sphingolipid metabolism to improve standard cancer therapies. Advances In Cancer Research. In Press. 2012 Abstract: Beckham TH, Cheng JC, Marrison ST, Liu X, Norris JS. Sphingosine 1-phosphate and acid ceramidase modulate the subcellular localization of the PTEN tumor suppressor. The Perry V. Halushka MUSC Student Research Day, Charleston, SC, November 2011 Marrison ST, Cheng JC, Beckham TH, Lu P, Liu A, Casey S, Liu X, Norris JS. Acid Ceramidase Over Expression in Response to Cigarette Smoke Exposure, The Perry V. Halushka MUSC Student Research Day, Charleston, SC, November 2011 Marrison ST, Cheng JC, Beckham TH, Lu P, Liu A, Casey S, Liu X, Norris JS. Acid Ceramidase Over Expression in Response to Cigarette Smoke Exposure. Hollings Cancer Center Retreat Fall 2011 Cheng JC, Marrison ST, Beckham TH, Keane TE, Marshall DT, Liu X, Norris JS. The Role Of Acid Ceramidase In The Failure Of Radiation Therapy For Prostate Cancer. The Perry V. Halushka MUSC Student Research Day, Charleston, SC, November 2011 Beckham TH, Cheng JC, Marrison ST, Liu X, Norris JS. Sphingosine 1-phosphate and acid ceramidase modulate the subcellular localization of the PTEN tumor suppressor. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Cheng JC, Liu X, Beckham TH, Keane TE, Hannun YA, Norris JS. Sphingolipid Metabolism In The Radiation Resistance And Relapse Of Prostate Cancer. MUSC MSTP Student Research Day, Charleston, SC, March 24, 2012 Marrison ST, Cheng JC, Beckham TH, Lu P, Liu X, Norris JS. Sphingosine 1-phosphate receptor signaling in mesenchymal stem cells. MUSC MSTP Research Day, Charleston, SC, March 24, 2012

Cheng JC, Liu X, Beckham TH, Keane TE, Hannun YA, Norris JS. Sphingolipid metabolism in the radiation resistance and relapse of prostate cancer. Keystone Symposium for Inflammation and Carcinogenesis. Dublin, Ireland, May 2012. Beckham TH, Cheng JC, Marrison ST, Liu X, Norris JS.: Sphingosine 1-phosphate and acid ceramidase modulate the subcellular localization of the PTEN tumor suppressor. MUSC Lipid Signaling In Cancer Program Retreat, Charleston, SC, 2012 Beckham TH, Cheng JC, Marrison ST, Liu X, Norris JS.: Sphingosine 1-phosphate and acid ceramidase modulate the subcellular localization of the PTEN tumor suppressor. Gordon Research Conference on Glycolipid and Sphingolipid Biology, Lucca, Italy, 2012 Brandon Bentzley (2009) Manuscript: Bentzley B, Fender K, Aston-Jones G. Behavioral economics for the neuroscientist: A review and new analytical approach. Psychopharmacology. Under Review, 2012 Abstract: Bentzley B Aston-Jones G. Microinjection Of Muscimol Into The Subthalamic Nucleus Attenuates Cocaine Consumption At High Price. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Bentzley B, Fender K, Aston-Jones G. Behavioral economics for the neuroscientist: Demand curve analysis of the within-session threshold procedure. 13th Annual Frontiers in Neuroscience Research Day, Seabrook Island, SC, 2012 Jennifer Blakely (2007) Manuscript: Eaddy A, Kale V, Blakely J, Kolisetty N, Mock J, Cummings B, Megyesi J, Schnellmann R. Genetic Ablation of Ca2+–Independent Phospholipase A2γ Induces Lipid Peroxidation, Oxidative DNA Damage, and Loss of Phospholipid Homeostasis in Mouse Kidney. Kidney International, Submitted, May 2012 Abstract: Blakely JL, Garrett SM, Beeson CC, Schnellmann RG. 5-Hydroxytryptamine-Class 2 Receptor-Mediated Mitochondrial Biogenesis as a Potential Therapeutic Strategy for Treatment of Acute Kidney Injury. American Society of Nephrology Kidney Week Philadelpha, PA; November 9-12, 2011 Blakely JL, Garrett SM, Beeson CC, Schnellmann RG. Class 2 5-Hydroxytryptamine Receptor-Mediated Mitochondrial Biogenesis as a Potential Therapeutic Strategy for Treatment of Acute Kidney Injury. MUSC MSTP Research Day, Charleston, SC, March 24, 2012

Manuscripts: Briggs LE, Kakarla J, Wessels A. The pathogenesis of atrial and atrioventricular septal defects with special emphasis on the role of the dorsal mesenchymal protrusion. Differentiation 2012 May 11. PMID: 22709652 Wessels A, van den Hoff MJ, Adamo RF, Phelps AL, Lockhart MM, Sauls K, Briggs LE, Norris RA, van Wijk B, Perez-Pomares JM, Dettman RW, Burch JB. Epicardially derived fibroblasts preferentially contribute to the parietal leaflets of the atrioventricular valves in the murine heart. Dev Biol 2012 Apr 24. PMID: 22546693 Abstracts: Briggs LE, Kakarla J, Phelps A, Wessels A The Role of Bone Morphogenetic Protein 4 in the Developing Inflow and Outflow Regions of the Heart. The Perry V. Halushka MUSC Student Research Day, Charleston, SC, November 2011 Briggs L, Kakarla J, Phelps A, Wessels A. The Role of Bone Morphogenetic Protein 4 in the Developing Inflow and Outflow Regions of the Heart. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Briggs LE, Phelps A, Kakarla J, van den Hoff M, Wessels A. BMP Signaling and Atrioventricular Septation. Weinstein Cardiovascular Development Conference, Chicago, IL, May 2-4, 2012 Wessels A, van den Hoff MJ, Adamo RF, Phelps AL, Lockhart MM, Sauls K, Briggs LE, Norris RA, van Wijk B, Perez-Pomares JM, Dettman RW, Burch JB Epicardially derived fibroblasts preferentially contribute to the parietal leaflets of the atrioventricular valves in the murine heart. Weinstein Cardiovascular Development Conference, Chicago, IL, May 2-4, 2012 Robert Cameron (2011) Abstracts: Cameron RB, Lindsey C, Wills LP, Trager RT, Beeson CC, Schnellmann RG, Peterson YK. Rational Development of Novel Biogenic Beta-Adrenergic Selective Agonists. The Perry V. Halushka MUSC Student Research Day, Charleston, SC, November 2011 Cameron RB, Lindsey C, Wills LW, Trager, RT, Beeson, C, Schnellmann RG, Peterson YK. Rational Development of Novel Biogenic Beta-Adrenergic Selective Agonists. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Joseph Cheng (2005) Manuscripts: Turner LS, Cheng JC, Beckham TH, Keane TE, Norris JS, Liu X. Autophagy is increased in prostate cancer cells overexpressing acid ceramidase and enhances resistance to C6 ceramide. Prostate Cancer and Prostatic Diseases. 2011; 14, 30-37

Beckham TH, Lu P, Cheng JC, Zhao D, Turner LS, Zhang X, Hoffman S, Armeson KE, Liu A, Marrison T, Hannun YA, Liu X. Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B. International Journal of Cancer. 2012 Feb 9. doi: 10.1002/ijc.27480. [Epub ahead of print] PubMed PMID: 22322590. Abstracts: Marrison ST, Cheng JC, Beckham TH, Lu P, Liu A, Casey S, Liu X, Norris JS. Acid Ceramidase Over Expression in Response to Cigarette Smoke Exposure, The Perry V. Halushka MUSC Student Research Day, Charleston, SC, November 2011 Beckham TH, Cheng JC, Marrison ST, Liu X, Norris JS. Sphingosine 1-phosphate and acid ceramidase modulate the subcellular localization of the PTEN tumor suppressor. The Perry V. Halushka MUSC Student Research Day, Charleston, SC, November 2011 Cheng JC, Marrison ST, Beckham TH, Keane TE, Marshall DT, Liu X, Norris JS. The Role Of Acid Ceramidase In The Failure Of Radiation Therapy For Prostate Cancer. The Perry V. Halushka MUSC Student Research Day, Charleston, SC, November 2011 Cheng JC, Liu X, Beckham TH, Keane TE, Hannun YA, Norris JS. Sphingolipid Metabolism In The Radiation Resistance And Relapse Of Prostate Cancer. MUSC MSTP Student Research Day, Charleston, SC, March 24, 2012 Marrison ST, Cheng JC, Beckham TH, Lu P, Liu X, Norris JS. Sphingosine 1-phosphate receptor signaling in mesenchymal stem cells. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Cheng JC, Liu X, Beckham TH, Keane TE, Hannun YA, Norris JS. Sphingolipid metabolism in the radiation resistance and relapse of prostate cancer. Keystone Symposium for Inflammation and Carcinogenesis. Dublin, Ireland, May 2012. Danielle Clark (2009) Abstracts: Clark D, Perkel J, Fraser J, Rollins LG, Nie X, Singh I, Jenkins D. NAC and Vitamin D Treatment Improving Hypoxic Ischemic Injury in the Neonatal Rat Model. The Perry V. Halushka MUSC Student Research Day, Charleston, SC, November 2011 Clark D, Perkel J, Fraser J, Rollins LG, Nie X, Singh I, Jenkins D. NAC and Vitamin D Treatment Improving Hypoxic Ischemic Injury in the Neonatal Rat Model. MUSC MSTP Student Research Day, Charleston, SC, March 24, 2012 Clark D, Perkel J, Fraser J, Rollins LG, Nie X, Singh I, Jenkins D. NAC and Vitamin D Treatment Improving Hypoxic Ischemic Injury in the Neonatal Rat Model. DCRI Anniversary Conference and Retreat, Charleston, SC, March 29, 2012

Mohammad Dahrouj (2010) Manuscripts: Ablonczy Z, Dahrouj M, Tang PH, Liu Y, Sambamurti K, Marmorstein A D, Crosson CE. Human Retinal Pigment Epithelium Cells as Functional Models for the RPE In Vivo. Investigative Ophthalmology & Visual Science, 52(12), 8614-20. doi:10.1167/iovs.11-8021, 2011 Abstract: Dahrouj M, Ablonczy Z Crosson CE. Natriuretic Peptides Protect the RPE From Advanced Glycation End Products-Induced Barrier Breakdown. The Perry V. Halushka MUSC Student Research Day, Charleston, SC, November 2011 Dahrouj M, McMillin JC, Crosson CE, Ablonczy Z. Using SD-OCT to Study the Effect of VEGF on Fluid Transport Across the RPE in vivo. MUSC MSTP Student Research Day, Charleston, SC, March 24, 2012 Dahrouj M, McMillin JC, Crosson CE, Ablonczy Z. Using SD-OCT to Study the Effect of VEGF on Fluid Transport across the RPE In Vivo. Association for Research in Vision & Ophthalmology (ARVO) Annual Meeting, Ft. Lauderdale, FL, May, 2012. Vivar LJ, Liu Y, Goletz P, Dahrouj M, Tang PH, Ablonczy Z. Human Retinal Pigment Epithelium Cells As Functional Models for Retinoid Metabolism. Association for Research in Vision & Ophthalmology (ARVO) Annual Meeting, Ft. Lauderdale, FL, May, 2012. Ablonczy A, Crosson CE, McMillin JC, Dahrouj M. SD-OCT To Link VEGF-induced RPE Dysfunction with The Development of Wet-AMD. ARVO/ISIE Imaging Conference: May 2012 Anna-Maria De Costa (2006) Manuscripts: De Costa AM, Young MR. Immunotherapy for head and neck cancer: advances and deficiencies. Anticancer Drugs. 2011 Aug;22(7):674-81 De Costa AM, Schuyler CA, Walker DD, Young MR. Characterization of the evolution of immune phenotype during the development and progression of squamous cell carcinoma of the head and neck. Cancer Immunol Immunother. 2011 Nov 25 [Epub ahead of print] Walker DD, Reeves TD, De Costa AM, Schuyler CA, Young MR. The effects of 1,25-dihydroxyvitamin D3 on tumor-associated immunosuppression in squamous cell carcinoma of the head and neck. Cytokine. 2012 March 24 [Epub ahead of print]

De Costa AM, Justis D, Schuyler CA, Young MR. Administration of a vaccine composed of dendritic cells pulsed with premalignant oral lesion lysate to mice bearing carcinogen-induced premalignant oral lesions stimulates a protective immune response. International Immunopharmacology. 2012 [Epub ahead of print] Abstracts: De Costa AM, Justis D, Schuyler C, Young R. Characterization of the evolution of immune phenotype during the development and progression of squamous cell carcinoma of the head and neck. 11th Annual Hollings Cancer Center Research Retreat, Charleston, SC, November 18, 2011 De Costa AM, Justis D, Schuyler C, Young R. Characterization of the Evolution of Immune Phenotype During the Development and Progression of Squamous Cell Carcinoma of the Head and Neck. The Perry V. Halushka MUSC Student Research Day, Charleston, SC, November 2011 Justis DN, De Costa AM, Schuyler C, Young R. The Role of Th17 and Treg Cells During HNSCC Carcinogenesis. The Perry V. Halushka MUSC Student Research Day, Charleston, SC, November 2011 De Costa AM, Justis D, Schuyler C, Young R. Administration Of A Vaccine Composed Of Dendritic Cells Pulsed With Premalignant Oral Lesion Lysate To Mice Bearing Carcinogen-Induced Premalignant Oral Lesions Stimulates A Protective Immune Response. MUSC MSTP Student Research Day, Charleston, SC, March 24, 2012 Danielle Desjardins (2011) Manuscripts: Ewen EP, Snyder CM, Wilson M, Desjardins D, Naya FJ. The Mef2A transcription factor coordinately regulates a costamere gene program in cardiac muscle. J Biol Chem. 2011 Aug 26;286(34):29644-53. Epub 2011 Jul 1. Fast EM, Toomey ME, Panaram K, Desjardins D, Kolaczyk ED, Frydman HM. Wolbachia enhance Drosophila stem cell proliferation and target the germline stem cell niche. Science. 2011 Nov 18;334(6058):990-2. Epub 2011 Oct 20. Layre E, Sweet L, Hong S, Madigan CA, Desjardins D, Young DC, Cheng TY, Annand JW, Kim K, Shamputa IC, McConnell MJ, Debono CA, Behar SM, Minnaard AJ, Murray M, Barry CE 3rd, Matsunaga I, Moody DB. A comparative lipidomics platform for chemotaxonomic analysis of Mycobacterium tuberculosis. Chem Biol. 2011 Dec 23;18(12):1537-49. Abstracts: Desjardins DM, Beeson CC. Mitochondrial Dysfunction in Degenerative Pathologies. The Perry V. Halushka MUSC Student Research Day, Charleston, SC, November 2011

Andre Eaddy (2004) Manuscript: Eaddy A, Cummings B, McHowat J, Schnellmann R. The Role of Endoplasmic Reticulum Ca2+-Independent Phospholipase A2γ in Oxidant-induced Lipid Peroxidation, Ca2+ Release, and Renal Cell Death. Toxicol Sci. 2012 May 15. [Epub ahead of print] Eaddy A, Kale V, Blakely J, Kolisetty N, Mock J, Cummings B, Megyesi J, Schnellmann R. Genetic Ablation of Ca2+–Independent Phospholipase A2γ Induces Lipid Peroxidation, Oxidative DNA Damage, and Loss of Phospholipid Homeostasis in Mouse Kidney. Kidney International, Submitted May 2012 Abstract: Eaddy A, Walker C, Caton C. “Crack” the Case: Report of Cocaine/Levamisole-induced Cutaneous Vasculitis. Presented at the Regional and National Society of General Internal Medicine Meetings, February and May 2012 Christopher Gault (2003) Manuscripts: Gault CR. Obeid LM. Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy. [Review] Critical Reviews in Biochemistry & Molecular Biology. 46(4):342-51, 2011 Aug. Mullen TD, Clarke CJ, Gault CR, Snider AJ, Wu BX, Heffernan-Stroud LA, Hannun YA, and Obeid LM. Complex regulation of sphingoid base metabolism by multiple sphingolipid enzymes. Journal of Lipid Research. Submitted 2012 Abstract: Selvam SP, Peterson YK, Gault CR, Obeid LM, Isaacs JS, Spiegel S, Smith CD, Ogretmen B. Regulation of Telomerase By Sphingosine Kinase 2/Sphingosine-1-Phosphate Signaling in Lung Cancer. The Perry V. Halushka MUSC Student Research Day. Charleston, SC. November 2011 Mullen TD, Clarke CJ, Gault CR, Snider AJ, Wu BX, Heffernan LA, Hannun YA, Obeid LM. Complex Regulation Of Sphingoid Base Metabolism By Multiple Sphingolipid Enzymes. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 George Russell Glenn (2010) Abstract: Glenn R, Tabesh A. Retrospective Noise Correction in Diffusional Kurtosis Imaging. MUSC MSTP Student Research Day, Charleston, SC, March 24, 2012 George Daniel Grass (2008) Manuscripts: Grass GD, Bratoeva M, Toole BP. Regulation of Invadopodia Formation and Activity by CD147. J Cell Science; 125(Part3): 777-788, 2012.

Dai L, Slomiany MG, Guinea MC, Bratoeva MP, Grass GD, Tolliver LB, Maria BL, Toole BP. CD147-dependent heterogeneity in malignant and chemoresistant properties of cancer cells. American Journal of Pathology. Submitted, May 2012 Wilkerson BA, Grass GD, Wing SB, Argraves WS, Argraves KM. S1P carrier-dependent regulation of endothelial barrier: HDL-S1P prolongs endothelial barrier enhancement as compared to albumin-S1P via effects on levels, trafficking and signaling of S1P1. Journal of Biological Chemistry. Submitted, May 2012 Abstract: Grass GD, Bratoeva M, Toole BP. EMMPRIN (CD147) is a Novel Regulator of Invadopodia Formation and Activity. The Perry V. Halushka MUSC Student Research Day. Charleston, SC. November 2011

Wilkerson BA, Grass GD, Wing SB, Argraves WS, Argraves KM. S1P carrier-dependent regulation of endothelial barrier: HDL-S1P prolongs endothelial barrier enhancement as compared to albumin-S1P via effects on levels, trafficking and signaling of S1P1. The Perry V. Halushka MUSC Student Research Day. Charleston, SC. November 2011 Grass GD, Bratoeva M, Toole BP. EMMPRIN (CD147) is a Novel Regulator of Invadopodia Formation and Activity. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Grass GD, Bratoeva M, Toole BP. Emmprin (CD147) is a Novel Regulator of Invadopodia Formation and Activity. 8th Annual APSA Conference. Chicago, IL: April 27-29, 2012 Linda Heffernan-Stroud (2004) Manuscripts: Heffernan-Stroud LA, Harper JL. Cutaneous Candida infection following radiation therapy for breast cancer. Journal of Dermatological Case Reports, Submitted 2012 Heffernan-Stroud LA, Obeid LM. Sphingosine kinase 1 and cancer. Advances in Cancer Research, Submitted 2012 Mullen TD, Clarke CJ, Gault CR, Snider AJ, Wu BX, Heffernan-Stroud LA, Hannun YA, Obeid LM. Complex regulation of sphingoid base metabolism by multiple sphingolipid enzymes. Journal of Lipid Research. Submitted 2012 Abstract: Carroll BL, Heffernan-Stroud LA, Obeid LM. Regulation of Sphingosine Kinase 1 By P53-Dependent Proteolysis. The Perry V. Halushka MUSC Student Research Day. Charleston, SC. November 2011

Casey O’Dell Holmes (2010) Manuscript: O'Dell CM, Das A, Wallace G 4th, Ray SK, Banik NL. Understanding the basic mechanisms underlying seizures in mesial temporal lobe epilepsy and possible therapeutic targets: a review. J Neurosci Res. 2012 May;90(5):913-24. doi: 10.1002/jnr.22829. Epub 2012 Feb 8. Russell Jenkins (2004) Manuscripts: Jenkins RW, Cannick L, Harper J. Use of MammoSite balloon brachytherapy for early stage breast cancer. Community Oncology 2011;8: 37-40. Hernandez-Corbacho MJ, Jenkins RW, Clarke CJ, Hannun YA, Obeid LM, Snider AJ, Siskind LJ. Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction. PLoS One. 2011;6(6):e20411 Truman JP, AI Gadban MM, Smith KJ, Jenkins RW, Mayroo N, Virella G, Lopes-Virella MF, Bielawska A, Hannun YA, Hammad SM. Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized LDL and oxidized LDL immune complexes: role in phagocytosis and cytokine release. Immunology, In press. 2012 Jenkins RW, McDonald K, Greenberg CS. Numb Chin Syndrome in Acute Myeloid Leukemia. American Journal of Medical Science. Accepted 2012 Salegio EA, Samaranch L, Jenkins RW, Clarke CJ, Lamarre C, Beyer J, Kells AP, Bringas J, San Sebastian W, Richardson RM, Rosenbluth KH, Hannun YA, Bankiewicz KS, Forsayeth J. Safety study of AAV2-mediated human acid sphingomyelinase expression in the non-human primate brain. Human Gene Therapy. Submitted 2012. Jenkins RW, Clarke CJ, Lucas J, Shabbir M, Wu B, Simbari F, Mueller J, Hannun YA, Lazarchick J, Shirai K. Evaluation of the Role of Secretory Sphingomyelinase and Bioactive Sphingolipids as Biomarkers in Hemophagocytic Lymphohistiocytosis. Blood. Submitted 2012 Book Chapters Mullen TD, Jenkins RW, Obeid LM, Hannun YA. Ceramide and Lipid Mediators in Apoptosis In: Apoptosis: Physiology and Pathology. Eds. Reed JC, Green DR. Cambridge University Press. pg. 88-105, 2011. Christopher Bryce Johnson (2009) Manuscripts: Rubinstein MP, Cloud CA, Garrett TE, Moore CJ, Schwartz KM, Johnson CB, Craig DH, Salem ML, Paulos CM, Cole DJ. Ex vivo interleukin-12-priming during CD8(+) T cell activation dramatically improves adoptive T cell transfer antitumor efficacy in a lymphodepleted host. J Am Coll Surg 214(4): 700-8, 2012

Johnson CB, Tikunov AP, Lee H, Wolak JE, Pediaditakis P, Romney DA, Holmuhamedov E, Gamcsik MP, Macdonald JM. 13 C magnetic resonance spectroscopy detection of changes in serine isotopomers reflects changes in mitochondrial redox status. Magn Reson Med doi: 10.1002/mrm.23296, 2011 Abstracts: Katikaneni L, Mulvihill DM, Johnson CB, Perkel J, Lambert D, Morgan P, Brown T, Chang E, Caplan M & Jenkins D. Brain biomarkers for the development of motor injury in term newborns exposed to chorioamnionitis; International Society for Developmental Neuroscience Annual Meeting, Mumbai, India, January 2012 Johnson CB, Cloud CA, Rubinstein MP, Cole DJ. Total body irradiation enhances the anti-tumor efficacy of adoptively transferred CD8+ T cells stimulated ex vivo with IL-12; Hollings Cancer Center Research Retreat, Charleston, SC, March 2012 Johnson CB, Cloud CA, Rubinstein MP, Cole DJ. Total body irradiation enhances the anti-tumor efficacy of adoptively transferred CD8+ T cells stimulated ex vivo with IL-12; American Association of Immunologists, Boston, MA, May 2012 Abstract: Johnson CB, Cloud CA, Rubinstein MP, Cole DJ.. Total body irradiation enhances the anti-tumor efficacy of adoptively transferred CD8+ T cells stimulated ex vivo with IL-12. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Rebecca Weber Knackstedt (2008) Manuscript: Knackstedt R, Moseley D, Wargovich MJ. Epigenetic Mechanisms Underlying Diet-Sourced Compounds in the Prevention and Treatment of Gastrointestinal Cancer. Anticancer Agents Med Chem. In Press, 2012 Book Chapter: Weber R, Taylor B, Engelman D. Laser Tissue Reactions and Dermatology. IN: Basics in Dermatological Laser Applications (First edition). S. Karger AG, ed. Medical and Scientific Publishers. 2011 Abstracts: Knackstedt R. MCAT Success Strategies. SNMA 2011 Regional Conference, Charleston, SC, October 2011. Knackstedt R, Moseley D, Morris J, Wargovich MJ. The Vitamin D receptor and RXR expression related to DNMT levels in a murine model of colitis. AACR Frontiers in Cancer Prevention Research. Boston, MA, October 2011.

Knackstedt R, Moseley D, Morris J, Wargovich MJ. The Vitamin D receptor and RXR expression related to DNMT levels in a murine model of colitis. The Perry V. Halushka MUSC Student Research Day. Charleston, SC. November 2011 Knackstedt R. Student Panel on MCAT Success. 2012 Ernest E. Just Symposium, Charleston, SC, February 2012. Knackstedt R, Moseley D, Morris J, Wargovich MJ. VDR and RXRα Expression in Murine Models of Colitis. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Craig Kutz (2010) Manuscript: Provost JJ, Rastedt D, Canine J, Ngyuen T, Haak A, Kutz C, Berthelsen N, Slusser A, Anderson K, Dorsam G, Wallert MA. Urokinase plasminogen activator receptor induced non-small cell lung cancer invasion and metastasis requires NHE1 transporter expression and transport activity. Cell Onc. 2012 Jan 31. 35,2 - 95-110. Abstracts: Kutz C, Atkison J, Bernanke J, Kubalak S. Noncanonical, Rapid Downstream Crosstalk Between TGFβ and Retinoic Acid Signaling Pathways As Revealed By the Proximity Ligation Assay. The Perry V. Halushka MUSC Student Research Day. Charleston, SC. November 2011 Kutz C, Atkison J, Bernanke J, Kubalak S. Noncanonical, Rapid Downstream Crosstalk Between TGFβ and Retinoic Acid Signaling Pathways As Revealed By the Proximity Ligation Assay. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Anthony Leonard (2007) Manuscript: Leonard A, Appleton KM, Luttrell LM, Peterson YK. A High-content, Live-cell, and Real-time Approach to the Quantitation of Ligand Induced β-arrestin2 and Class A /Class B GPCR Mobilization. Microscopy and Microanalysis, Submitted May 2012 Abstracts: Leonard AP, Perron N, Nasarre C, Beeson C, Rohrer B. Inhibition of Mitochondrial Fission is Associated with Neuroprotection in Retinitis Pigmentosa. National MD/PhD Student Conference, Keystone, CO, July 2011 Leonard AP, Perron N, Nasarre C, Beeson C, Rohrer B.Mitochondrial Fusion is Linked to Bioenergetic Capacity and Cell Survival in a Cell-based Model of PDE6B-dependent Retinitis Pigmentosa. The Perry V. Halushka MUSC Student Research Day. Charleston, SC. November 2011 Leonard AP, Peterson YK, Perron NR, Beeson CC, Rohrer BM. High Content Imaging-based Automated Classification of Mitochondrial Morphology. MUSC MSTP Research Day, Charleston, SC, March 24, 2012

Leonard AP, Peterson YK, Perron NR, Beeson CC, Rohrer BM. High Content Imaging Analysis of Mitochondrial Morphology in Retinal Degeneration. Frontiers in Neuroscience Conference, Seabrook Island, SC, March 2012 Leonard AP, Peterson YK, Perron NR, Beeson CC, Rohrer BM. High Content Imaging Reveals Mitochondrial Morphological Insights into the Mechanism of Neuroprotective Drug Candidates in Retinitis Pigmentosa. National Clinical and Translational Sciences Predoctoral Meeting, Mayo Clinic, Rochester, MN, May 2012 Sarah Tucker Marrison (2008) Manuscript: Beckham TH, Lu P, Cheng JC, Zhao D, Turner LS, Zhang X, Hoffman S, Armeson KE, Liu A, Marrison T, Hannun YA, Liu X. Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B. International Journal of Cancer. 2012 Feb 9. doi: 10.1002/ijc.27480. [Epub ahead of print] PubMed PMID: 22322590. Beckham TH, Cheng JC, Marrison ST, Norris JS, Liu X. Interdiction of sphingolipid metabolism to improve standard cancer therapies. Advances In Cancer Research. In Press. 2012 Abstract: Marrison ST, Cheng JC, Beckham TH, Lu P, Liu A, Casey S, Liu X, Norris JS. Acid Ceramidase Over Expression in Response to Cigarette Smoke Exposure. Hollings Cancer Center Retreat Fall 2011 Marrison ST, Cheng JC, Beckham TH, Lu P, Liu A, Casey S, Liu X, Norris JS. Acid Ceramidase Over Expression in Response to Cigarette Smoke Exposure. The Perry V. Halushka MUSC Student Research Day, Charleston, SC, November 2011 Beckham TH, Cheng JC, Marrison ST, Liu X, Norris JS. Sphingosine 1-phosphate and acid ceramidase modulate the subcellular localization of the PTEN tumor suppressor. The Perry V. Halushka MUSC Student Research Day, Charleston, SC, November 2011 Cheng JC, Marrison ST, Beckham TH, Keane TE, Marshall DT, Liu X, Norris JS. The Role Of Acid Ceramidase In The Failure Of Radiation Therapy For Prostate Cancer. The Perry V. Halushka MUSC Student Research Day, Charleston, SC, November 2011 Marrison ST, Cheng JC, Beckham TH, Lu P, Liu X, Norris JS. Sphingosine 1-phosphate receptor signaling in mesenchymal stem cells. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Beckham TH, Cheng JC, Marrison ST, Liu X, Norris JS. Sphingosine 1-phosphate and acid ceramidase modulate the subcellular localization of the PTEN tumor suppressor. MUSC MSTP Research Day, Charleston, SC, March 24, 2012

Beckham TH, Cheng JC, Marrison ST, Liu X, Norris JS.: Sphingosine 1-phosphate and acid ceramidase modulate the subcellular localization of the PTEN tumor suppressor. MUSC Lipid Signaling In Cancer Program Retreat, Charleston, SC, 2012 Beckham TH, Cheng JC, Marrison ST, Liu X, Norris JS.: Sphingosine 1-phosphate and acid ceramidase modulate the subcellular localization of the PTEN tumor suppressor. Gordon Research Conference on Glycolipid and Sphingolipid Biology, Lucca, Italy, 2012 Ahmad Mashmoushi (2007) Abstracts: Mashmoushi A, Hofbauer A, Donohue J, Ruiz P, Gilkeson G, Perl A, Oates J. Role Of Endothelial Nitric Oxide Synthase (eNOS) in Lupus Nephritis. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Jamie Mills (2011) Abstracts: Mills JN, Bandurraga SG, Kramer R, Rumboldt T, Neumann C, Turner DP, Findlay VJ. MicroRNA 510 as a Predictive Marker for Response to Platinum-Based Chemotherapy in Triple Negative and HER2+ Breast Cancer Patients. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Mills JN, Bandurraga SG, Kramer R, Rumboldt T, Neumann C, Turner DP, Findlay VJ. MicroRNA 510 as a Predictive Marker for Response to Platinum-Based Chemotherapy in Triple Negative and HER2+ Breast Cancer Patients. 1st Annual RNA Pathobiology in Cancer Symposium, Charleston, SC, June 2012 Keely Morris (2006) Abstracts: Morris KL, Qiao F, He S, Atkinson C, Kulik L, Holers MV, Tomlinson S. Pathogenic Natural Igm Antibodies Initiate The Inflammatory Response Important For Both HepaticIschemia/Reperfusion Injury And Liver Regeneration After Partial Hepatectomy, The Perry V. Halushka MUSC Student Research Day. Charleston, SC. November 2011 Morris KL, Qiao F, He S, Atkinson C, Kulik L, Holers MV, Tomlinson S. For Both Hepatic Ischemia/Reperfusion Injury And Liver Regeneration After Partial Hepatectomy. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Khaled Moussawi (2005) Manuscripts: Shen H, Moussawi K, Zhou W, Toda S, Kalivas PW. Heroin relapse requires LTP-like plasticity mediated by NR2B-containing receptors. Proceedings of the National Academy of Sciences of the United States of America. 2011, Nov 29;108(48):19407-12

Kupchik YM, Moussawi K, Tang XC, Wang X, Kolokithas RA, Ogburn KB, Kalivas PW. The effect of N-acetylcysteine on neurotransmission in the accumbens and relapse to cocaine. Biological Psychiatry. Dec 1 [Epub ahead of print], 2011 Moussawi K, Riegel AC, Nair S, Kalivas PW. Extracellular glutamate: functional compartments operate in different concentration ranges. Front Syst Neurosci. 5:94. Epub 2011 Nov 24, 2011 Wang X, Moussawi K, Shen H, Kalivas PW. Role of mGlur5 neurotransmission in reinstated cocaine-seeking. Addiction Biology. Accepted 2012 Stefanik MT, Moussawi K, Kupchik YM, Smith KC, Miller RL, Huff ML, Deisseroth K, Kalivas PW, LaLumiere RT. Optogenetic inhibition of cocaine seeking in rats. Addiction Biology. Submitted 2012 Thomas Mullen (2003) Manuscripts: Mullen TD, Obeid LM. Ceramide and Apoptosis: Exploring the Enigmatic Connections Between Sphingolipid Metabolism and Programmed Cell Death. Anticancer Agents Med Chem. 2011 Jun 27. [Epub ahead of print]. PMID: 21707511. Mullen TD, Hannun YA, Obeid LM. Ceramide synthases at the centre of sphingolipid metabolism and biology. Biochem J. 2012 Feb 1;441(3):789-802. PMID: 22248339. Mullen TD, Sharma AK, Varma AK. Cervical osteomyelitis after placement of a self-expanding plastic stent for palliation of dysphagia associated with chemoradiation-induced esophageal strictures. Head Neck. 2012 Feb 24 [Epub ahead of print]PMID: 22367919. Mullen TD, Clarke CJ, Gault CR, Snider AJ, Wu BX, Heffernan-Stroud LA, Hannun YA, Obeid LM. Complex regulation of sphingoid base metabolism by multiple sphingolipid enzymes. Journal of Lipid Research. Submitted 2012 Book Chapters Mullen TD, Jenkins RW, Obeid LM, Hannun YA. Ceramide and Lipid Mediators in Apoptosis In: Apoptosis: Physiology and Pathology. Eds. Reed JC, Green DR. Cambridge University Press. pg. 88-105, 2011. Abstract: Mullen TD, Clarke CJ, Gault CR, Snider AJ, Wu BX, Heffernan LA, Hannun YA, Obeid LM. Complex Regulation Of Sphingoid Base Metabolism By Multiple Sphingolipid Enzymes. MUSC MSTP Research Day, Charleston, SC, March 24, 2012

Daniel Neitzke (2010) Abstract: Neitzke D, Taylor J, Khouri G, Borckardt J, George M. Repetitive Transcranial Magnetic Stimulation of the Left Dorsolateral Prefrontal Cortex Promotes Resilience, Prevents Learned Helplessness. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Benjamin Newcomb (2009) Manuscript: Montefusco DJ, Newcomb B, Gandy JL, Brice SE, Matmati N, Cowart LA, Hannun YA. Sphingoid bases and the serine catabolic enzyme CHA1 define a novel Feedforward/Feedback mechanism in the response to serine availability. Journal of Biological Chemistry. 2012, 287(12):9280-9. Abstract: Perry DM, Newcomb B, Wu B, Kitatani K, Hannun YA. Differential Regulation of IL-6 Production by Sphingolipid Catabolism: Role of Acid Sphingomyelinase in p38 Activation. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Armina Wiggins Omole Manuscript: Wiggins AT, Smith RJ, Shen HW, Kalivas PW. Integrins Modulate Relapse to Cocaine-Seeking. Journal of Neuroscience 2011, 31(45):16177-16184;doi:10.1523/ JNEUROSCI.3816-11.2011 Abstract: Smith AW, Wiggins AT, Kalivas PW. Matrix Metalloproteinases in Reinstated Cocaine Seeking, The Perry V. Halushka MUSC Student Research Day. Charleston, SC, November 2011 Joseph Palatinus (2005) Manuscripts: Palatinus JA, Rhett JM, Gourdie RG.The connexin43 carboxyl terminus and cardiac gap junction organization. Biochim Biophys Acta. 2012 Aug;1818(8):1831-43. Epub 2011 Aug 9. Abstract: Palatinus JA, Gourdie RG. A Connexin 43 C-terminal peptide increases PKC-epsilon mediated phosphorylation of Connexin 43. International Gap Junction Conference, Ghent, Belgium, July 2011 Palatinus JA, Gourdie RG.Phosphoregulation of the Cx43 Carboxy-terminus in Cardiac Injury. The Perry V. Halushka MUSC Student Research Day. Charleston, SC. November 2011

David Perry (2006) Manuscripts: Perry DM, Kitatani K, Roddy P, El-Osta M, Hannun YA. Identification and Characterization of PP2C Activation by Ceramide. J Lipid Res. Accepted 2012 Abstract: Perry DM, Kitatani K, Roddy P, El-Osta M, Hannun Y. Identification and Characterization of PP2C Activation By Ceramide. The Perry V. Halushka MUSC Student Research Day. Charleston, SC. November 2011 Perry DM, Newcomb B, Wu B, Kitatani K, Hannun YA. Differential Regulation of IL-6 Production by Sphingolipid Catabolism: Role of Acid Sphingomyelinase in p38 Activation. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Saleh Rachidi (2010) Abstract: Rachidi S, Qin T, Zheng J, Li Z. Identifying Cancer-Associated Inflammatory Genes: A Data-Mining Approach. The Perry V. Halushka MUSC Student Research Day. Charleston, SC. November 2011 Rachidi S, Qin T, Zheng J, Li Z. Human Multi-Cancer Gene Expression Analysis Defines an Inflammatory Cancer-Associated Molecular Pattern (iCAMP) with Prognostic Significance. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Ryan Rhome (2004) Manuscript: Rhome R, Singh A, Kechichian T, Drago M, Morace G, Luberto C, Del Poeta M. Surface localization of glucosylceramide in Cryptococcus neoformans allows targeting as a potential anti-fungal. PLoS One. 2011 Jan 21;6(1):e15572. Qureshi A, Wray D, Rhome R, Barry W, Del Poeta M. Detection of antibody against fungal glucosylceramide in immunocompromised patients. Mycopathologia. 2012 Jun;173(5-6):419-25. Epub 2011 Oct 5. Russo JK, Armeson KE, Rhome R, Spanos M, Harper J. Dose to level I and II axillary lymph nodes and lung by tangential field radiation in patients undergoing postmastectomy radiation with tissue expander reconstruction. Radiation Oncology, 2011 Dec 28;6:179. Abstracts: Rhome R, Wahlquist A, Garrett-Mayer E, Harper JL. Investigation of Epidemiological Factors As Barriers To Indicated Radiation Therapy in Post-Mastectomy Breast Cancer Patients in South Carolina. San Antonio Breast Cancer Symposium, San Antonio, TX, 2011

Douglas Roberts-Wolfe (2011) Manuscript: Roberts-Wolfe D, Sacchet M, Hastings E, Roth H and Britton W. Mindfulness training alters emotional memory recall compared to active controls: support for an emotional information processing model of mindfulness. Frontiers in Human Neuroscience 6:15. doi:10.3389/fnhum.2012.00015, 2012 Sarah Brice Russo (2010) Manuscripts: Montefusco DJ, Newcomb B, Gandy JL, Brice SE, Matmati N, Cowart LA, Hannun YA. Sphingoid bases and the serine catabolic enzyme CHA1 define a novel Feedforward/Feedback mechanism in the response to serine availability. Journal of Biological Chemistry. 2012, 287(12):9280-9. Book Chapter: Brice SE, Ross JS, Cowart LA. Sphingolipids in obesity, type 2 diabetes, and metabolic disease. IN: Sphingolipids in Health and Disease. Erich Gulbins, ed. In press, 2012 Abstracts: Brice SE, Van Laer A, Baicu CF, Geng T, Kasiganesan H, Zile M, Cowart LA. Bioactive Sphingolipids Regulate Cardiac Hypertrophy and Autophagy in Lipid Overload: A Role for Myristate and Its Derivatives. The Perry V. Halushka MUSC Student Research Day, Charleston, SC, November 2011 Brice SE. A High-Myristate Diet Induces Sphingolipid-Dependent Cardiac Hypertrophy, Dysfunction, and Autophagy: A Requirement for (Dihydro)Ceramide Synthase 5 in Sphingolipid-Dependent Cardiac Autophagy. Southeastern Regional Lipid Conference – Cashiers, NC, November, 2011 Brice SE, Baicu CF, Van Laer A, Geng T, Kasiganesan H, Zile MR, Cowart LA. The Role of Sphingolipids and (Dihydro) Ceramide Synthase 5 in Diabetic Cardiomyopathy in Mice. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Brice SE. The Role of Sphingolipids and (Dihydro)Ceramide Synthase 5 in Diabetic Cardiomyopathy. Biochemistry Research and Methods Seminar, Medical University of South Carolina, Charleston, SC, March, 2012 Brice SE. The Role of Sphingolipids and (Dihydro)Ceramide Synthase 5 in Diabetic Cardiomyopathy. Society for Heart and Vascular Metabolism Annual Meeting, Oxford, United Kingdom, June, 2012 Sahar Saddoughi (2006) Manuscript: Saddoughi SA, Garrett-Mayer E, Chaudhary U, O'Brien PE, Afrin LB, Day TA, Gillespie MB, Sharma AK, Wilhoit CS, Bostick R, Senkal CE, Hannun YA, Bielawski J, Simon GR, Shirai K, Ogretmen B. Results of a phase II trial of gemcitabine plus doxorubicin in

patients with recurrent head and neck cancers: serum C₁₈-ceramide as a novel biomarker for monitoring response. Clin Cancer Res. 2011 Sep 15;17(18):6097-105. Epub 2011 Jul 26. Senkal CE, Ponnusamy S, Manevich Y, Meyers-Needham M, Saddoughi SA, Mukhopadyay A, Dent P, Bielawski J, Ogretmen B. Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network. J Biol Chem. 2011 Dec 9;286(49):42446-58. Epub 2011 Oct 19. Abstracts: Creel JS, Saddoughi S, Ogretmen B. The Effect of Fingolimod (FTY720) on Small Cell Lung Cancer and Non-Small Cell Lung Cancer. The Perry V. Halushka MUSC Student Research Day. Charleston, SC. November 2011 Jennifer Scott (2009) Manuscript: Cunningham MA, Naga OS, Eudaly JG, Scott JL, Gilkeson GS. Estrogen receptor alpha modulates toll-like receptor signaling in murine lupus. Clinical immunology. 2012, 144(1):1-12. Abstracts: Scott JL, Cunningham M, Naga OS, Gilkeson G. Absence of Estrogen Receptor Alpha Reduces Plasmacytoid Dendritic Cells and Type I Interferon Production in Lupus Prone Mice. The Perry V. Halushka MUSC Student Research Day. Charleston, SC. November 2011 Scott JL, Cunningham M, Naga OS, Gilkeson G. Absence of Estrogen Receptor Alpha Reduces the Number and Function of Plasmacytoid Dendritic Cells in Lupus Prone Mice. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Amena Smith Manuscript: Smith AW, Rohrer B, Wheless L, Samantaray S, Ray S, Inoue J, Azuma M, Banik N. The effect of calpain inhibition on visual pathway function during the course of chronic-progressive optic neuritis. J Neurosci. Submitted 2012 Abstract: Smith AW, Wiggins AT, Kalivas PW. Matrix Metalloproteinases in Reinstated Cocaine Seeking, The Perry V. Halushka MUSC Student Research Day. Charleston, SC, November 2011

Joshua Smith (2008) Manuscripts: McDowell ML, Das A, Smith JA, Varma AK, Ray SK, Banik NL. Neuroprotective effects of genistein in VSC4.1 motoneurons exposed to activated microglial cytokines. Neurochem Int. 2011;59(2):175-84. PMCID: 3153433. Smith JA, Das A, Ray SK, Banik NL. Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases. Brain Res Bull. 2012;87(1):10-20. Haar CP, Hebbar P, Wallace GCt, Das A, Vandergrift WA, 3rd, Smith JA, et al. Drug resistance in glioblastoma: a mini review. Neurochem Res. 2012;37(6):1192-200. Park S, Nozaki K, Guyton MK, Smith JA, Ray SK, Banik NL. Calpain Inhibition Attenuated Morphological and Molecular Changes in Skeletal Muscle of Experimental Allergic Encephalomyelitis Rats. J Neurosci Res. In press, 2012 Abstracts: Smith JA, Das A, Wallace GC, Ray SK, Banik NL. Estrogen Receptor Agonists Protect Against Glutamate Excitotoxicity In Spinal Cord Slice Cultures. The Perry V. Halushka MUSC Student Research Day. Charleston, SC. November 2011 Smith JA, Das A, Wallace GC IV, Ray SK, Banik NL. Estrogen receptor agonists protect against glutamate excitotoxicity in rat spinal cord slices. American Society for Neurochemistry 2012 Meeting, Baltimore, MD. Smith JA, Park S, Das A, Nozaki K, Krause JS, Banik NL. Identifying Telomerase as a Target for Estrogen Neuroprotection Following Spinal Cord Injury. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Kyle Strickland (2005) Abstract: Strickland KC, Krupenko SA. Regulation of Mitochondrial Protein Biosynthesis By Formylation and Deformylation of MethionyltRNA. The Perry V. Halushka MUSC Student Research Day. Charleston, SC, November 2011 Alton Sutter (2007) Manuscript: Evans ZP, Palanisamy AP, Sutter AG, Ellett JD, Ramshesh VK, Attaway H, Schmidt MG, Schnellmann RG, Chavin KD. Mitochondrial uncoupling protein-2 deficiency protects steatotic mouse hepatocytes from hypoxia/reoxygenation. Am J Physiol Gastrointest Liver Physiol. 2012 Feb 1;302(3):G336-42. Epub 2011 Nov 17. Abstracts: Sutter A, Ellett J, Chavin K. Interleukin-10 And Kupffer Cells Protect The Fatty Liver From Ischemia And Reperfusion Injury. The Perry V. Halushka MUSC Student Research Day. Charleston, SC. November 2011

Sutter AG, Chavin KD. TLR4 Knockout Protects Obese Mice from Steatosis Associated Liver Inflammation and Injury. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Peter Tang (2006) Manuscripts: Boyer NP, Tang PH, Higbee D, Ablonczy Z, Crouch RK, Koutalos Y. Lipofuscin and A2E accumulate with age in the retinal pigment epithelium of Nrl-/- mice. Photochem Photobiol 2012, 10.1111/j.1751-1097.2012.01127.x. Tang PH, Buhusi M, Ma JX, Crouch RK. RPE65 is present in human green/red cones and promotes photopigment regeneration in an in vitro cone cell model. J Neurosci 2011, 31(50):18618-18626 Ablonczy Z, Dahrouj M, Tang PH, Liu Y, Sambamurti K, Marmorstein AD, Crosson C. Human retinal pigment epithelium cells as functional models for the RPE in vivo. Invest Ophthalmol Vis Sci 2011, 52(12):8614-8620 Tang PH, Kono M, Koutalos Y, Ablonczy Z, Crouch RK. New insights into the retinoid metabolism and cycle of the retina. Prog Retin Eye Res. In Press 2012 Tang PH, Vivar LJ, Dahrouj M, Liu Y, Oatis Jr. J, Ablonczy Z. Retinoid metabolism and chromophore synthesis in cultured fetal human retinal pigment epithelium cells. Invest Ophthalmol Vis Sci. Submitted 2012 Book Chapter: Tang PH, Crouch RK. The essential role of retinoids as ligands for visual pigment formation and survival of cone photoreceptors. IN: CRC Handbook of Photochemistry & Photobiology. In Press 2012 Abstract: Tang PH, Buhusi M, Crouch RK. RPE65 Protein is Present Within Human Cones to Enhance Photopigment Regeneration for Vision. The Perry V. Halushka MUSC Student Research Day. Charleston, SC. November 2011 Tang PH, Wheless L, Ma JX, Crouch RK. RPE65 Is Present Within Human Cone Photoreceptors And Is Required For Efficient Cone Visual Pigment Regeneration. The Perry V. Halushka MUSC Student Research Day. Charleston, SC. November 2011 Vivar LJ, Liu Y, Goletz P, Dahrouj M, Tang PH, Ablonczy Z. Human Retinal Pigment Epithelium Cells As Functional Models for Retinoid Metabolism. Association for Research in Vision & Ophthalmology (ARVO) Annual Meeting, Ft. Lauderdale, FL, May, 2012.

Joseph Taylor (2008) Manuscript: Taylor JJ, Borckardt JJ, George MS (2012) Endogenous Opioids Mediate Left Dorsolateral Prefrontal Cortex rTMS-Induced Analgesia. Pain 153, 1219-1225. Book Chapter: George MS, Taylor JJ, Short B: Treating the Depressions with Superficial Brain Stimulation Methods (ECT, TES, TMS, rTMS, tDCS, epidural and subdural stimulation). IN: Handbook of Brain Stimulation, Lozano and Hallett (eds.); Handbook of Clinical Neurology, 3rd Series, Elsevier Press, 2012. Abstract: Taylor JJ, Borckardt JJ, George MS. Endogenous Opioids Mediate Left Dorsolateral Prefrontal Cortex RTMS-Induced Analgesia. The Perry V. Halushka MUSC Student Research Day. Charleston, SC. November 2011 Neitzke D, Taylor J, Khouri G, Borckardt J, George M. Repetitive Transcranial Magnetic Stimulation of the Left Dorsolateral Prefrontal Cortex Promotes Resilience, Prevents Learned Helplessness. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Taylor JJ, Borckard JJ, George MS. Endogenous opioids mediate left dorsolateral prefrontal cortex rTMS-induced analgesia. 23rd Annual Meeting of the American Neuropsychiatric Association, 2012. Salatino A, Li X, Taylor JJ, Mu Q, Bohning D, George MS, Ricci. Imaging the neural correlates of rightward neglect-like bias in healthy volunteers: an interleaved TMS/fMRI study. 8th Federation of European Neuroscience Societies (FENS) Forum of Neuroscience, 2012. Hanlon CA, Canterberry M, Taylor JJ, DeVries W, Li X, Brown TS, George MS. Differentiating neural networks with interleaved TMS-BOLD imaging. Society for Brain Mapping and Therapeutics. Annual Meeting, Toronto, CA. June 2012. Lee Wheless (2005) Manuscripts: Barnado A, Wheless L, Meyer AK, Gilkeson GS, Kamen DL. Quality of Life in Patients with Systemic Lupus Erythematosus (SLE) Compared to Related Controls within a Unique African American Cohort. Lupus 2012; 21:563-9. Wheless L, Kistner-Griffin E, Jorgensen TJ, Ruczinski I, Berthier-Schaad Y, Kessing B, Hoffman-Bolton J, Francis L, Shugart YY, Strickland PT, Kao WHL, Alani RM, Smith MW, Alberg AJ. A community-based study of nucleotide excision repair polymorphisms in relation to risk of non-melanoma skin cancer. J Invest Dermatol 2012; 132:1354-62.

Ruczinski I*, Jorgensen TJ* (co-first authors), Shugart YY, Berthier-Schaad Y, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WHL, Wheless L, Francis L, Alani RM, Strickland PT, Smith MW, Alberg AJ. Nonmelanoma skin cancer as a marker of a cancer-prone phenotype: Potential role of DNA repair gene variants. Carcinogenesis. In press 2012 Jorgensen TJ, Ruczinski I, Wheless L, Shugart YY, Berthier-Schaad Y, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WHL, Francis L, Alani RM, Strickland PT, Smith MW, Alberg AJ. Variants in Hedgehog genes and the risk of cancer. Cancer Epidemiol. In press 2012 Alberg AJ, Jorgensen TJ, Ruczinski I, Wheless L, Shugart YY, Berthier-Schaud Y, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WHL, Francis L, Alani R, Smith MW, Strickland PT. “DNA repair gene variants in relation to overall cancer risk: A population-based study. Cancer Epidemiol Biomarkers Prev. Submitted 2012 Smith AW, Rohrer B, Wheless L, Samantaray S, Ray S, Inoue J, Azuma M, Banik N. The effect of calpain inhibition on visual pathway function during the course of chronic-progressive optic neuritis. J Neurosci. Submitted 2012 Jorgensen TJ, Ruczinski I, Wheless L, Shugart YY, Berthier-Schaad Y, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WHL, Francis L, Alani RM, Strickland PT, Smith MW, Alberg AJ. Fibroblast growth factor 2 receptor polymorphisms associated with increased risk of basal cell carcinoma. J Invest Dermatol. Submitted 2012 Wheless L, Kistner-Griffin E, Shugart YY, Kao WHL, Jorgensen TJ, Berthier-Schaad Y, Kessing B, Hoffman-Bolton J, Ellerbe C, Francis L, Strickland PT, Alani RM, Smith MW, Alberg AJ, Ruczinski I. Practical consideration in exploring gene-gene interactions: An example using nucleotide excision repair pathway genes in relation to nonmelanoma skin cancer. In preparation 2012 Wheless L*, Lam TK* (co-first authors), Jorgensen TJ, Ruczinski I, Berthier-Schaad Y, Kessing B, Hoffman-Bolton J, Woodward L, Yao Y, Strickland PT, Smith MW, Alberg AJ. XPD variant Lys751Gln is associated with increased risk of lung cancer independent of smoking. In preparation 2012 Barnado A, Wheless L, Meyer AK, Gilkeson GS, Kamen DL. Pregnancy Outcomes among African American Patients with Systemic Lupus Erythematosus (SLE) Compared to Controls. In preparation 2012 Abstracts: Tang PH, Wheless L, Ma JX, Crouch RK. RPE65 Is Present Within Human Cone Photoreceptors And Is Required For Efficient Cone Visual Pigment Regeneration. The Perry V. Halushka MUSC Student Research Day. Charleston, SC. November 2011

Wheless L, Kistner-Griffin E, Jorgensen TJ, Ruczinski I, Berthier-Schaad Y, Kessing B, Hoffman-Bolton J, Woodward L, Yao Y, Strickland PT, Kao WHL, Alani RM, Smith MW, Alberg AJ. A Community-Based Study Of Nucleotide Excision Repair Polymorphisms In Relation To Risk Of Non-Melanoma Skin Cancer. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Wheless L, Kistner-Griffin E, Jorgensen TJ, Ruczinski I, Berthier-Schaad Y, Kessing B, Hoffman-Bolton J, Francis L, Shugart YY, Strickland PT, Kao WHL, Alani RM, Smith MW, Alberg AJ. A community-based study of nucleotide excision repair polymorphisms in relation to risk of non-melanoma skin cancer. AACR annual meeting, Chicago, IL, March 2012 Wheless L, Kistner-Griffin E, Shugart YY, Kao WHL, Jorgensen TJ, Berthier-Schaad Y, Kessing B, Hoffman-Bolton J, Francis L, Strickland PT, Alani RM, Smith MW, Alberg AJ, Ruczinski I. Practical consideration in exploring gene-gene interactions: An example using nucleotide excision repair pathway genes in relation to nonmelanoma skin cancer. Society for Investigative Dermatology annual meeting, Raleigh, NC, May 2012 Ryan Whitaker (2008) Manuscript: Smith MA, McInnes C, Whitaker RM, Lindsey CC, Comer RF, Beeson CC, Schnellmann RG. Calpain 10 Homology Modeling with CYGAK and Increased Lipophilicity Leads to Greater Potency and Efficacy in Cells. ACS Chem Biol. [Epub ahead of print]. 2012 Abstract: Whitaker RM, Covington MD, Schnellmann RG. (2011). Calpain 10 Loss Mediates Increased Susceptibility to Nephrotoxicity. American Society of Nephrology Kidney Week, Philadelphia, PA. November 2011 Whitaker RM, Smith MA, Covington, MD, Schnellmann, RG (2012). Depletion of Renal Calpain 10 Mediates Early Renal Mitochondrial Dysfunction in Streptozotocin-Induced Diabetic Rats. Keystone Symposium - Mitochondrial Dynamics and Function, Banff, Alberta, Canada. March 2012 Whitaker R, Wills L, Schnellmann R. Stimulation of Mitochondrial Biogenesis with PDE3 Inhibitors. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Parker Wilson (2005) Manuscript: El-Shewy HM, Sohn M, Wilson P, Lee MH, Hammad SM, Luttrell LM, Jaffa AA. Low-density lipoprotein induced expression of connective tissue growth factor via transactivation of sphingosine 1-phosphate receptors in mesangial cells. Mol Endocrinol. 2012 May;26(5):833-45. Epub 2012 Mar 15.

Xiaoyi Zhang (2008) Abstracts: Zhang X, Yu H, Kirkwood KL. MKP-1 deficiency enhances epithelial neoplasia in a murine oral cancer model. The Perry V. Halushka MUSC Student Research Day. Charleston, SC. November 2011 Zhang X, Yu H, D’Silva N, Kirkwood KL. MKP-1 Deficiency Enhances Murine Oral Neoplasia. MUSC MSTP Research Day, Charleston, SC, March 24, 2012 Zhang X, Yu H, D’Silva N, Kirkwood KL. MKP-1 deficiency enhances murine oral neoplasia at the MUSC 10th Annual Head and Neck Multidisciplinary Research Workshop, Charleston, SC, April 2012; 1st place Zhang X, Yu H, D’Silva N, Kirkwood KL. MKP-1 deficiency enhances murine oral neoplasia at the Keystone Symposia: The Role of Inflammation in Carcinogenesis, Dublin, Ireland, May 2012

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