chapter 3 cells - weebly · 2018-09-06 · 27 clinical application diseases at the organelle level...
Post on 26-Mar-2020
7 Views
Preview:
TRANSCRIPT
1
Hole’s Human
Anatomy and Physiology Eleventh Edition
Chapter 3
Shier w Butler w Lewis
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
2
Chapter 3: Cells
Human body cells:
• 70 trillion cells
• 260 different types
• eukaryotic
•vary in size
• possess distinctive shapes to fit their function
• measured in micrometers
4
Cell Membrane
• outer limit of cell
• controls what moves in and out of cell
• selectively permeable
5
Cell Membrane
Composed maily of: 1. phospholipid bilayer
• water-soluble “heads” form surfaces • water-insoluble “tails” form interior • permeable to lipid (nonpolar)-soluble substances
2. proteins • receptors • self-markers • transport
6
Cytoplasmic Organelles
Endoplasmic Reticulum • connected, membrane-bound sacs, canals, and vesicles
• transport system
• rough ER • studded with ribosomes
• protein synthesis
• smooth ER • lipid synthesis
• break down of drugs
Ribosomes • free floating or connected to ER
• provide structural support
7
Cytoplasmic Organelles
Golgi apparatus •stack of flattened, membranous sacs •modifies, packages and delivers proteins
Mitochondria •membranous sacs with inner partitions •generate energy
Vesicles •membranous sacs •store substances
8
Cytoplasmic Organelles
Lysosomes • enzyme-containing sacs • digest worn out cell parts or unwanted substances
Peroxisomes • enzyme-containing sacs • break down organic molecules
Centrosome • two rod-like centrioles • distributes chromosomes during cell division
9
Cytoplasmic Organelles
Cilia • short hair-like projections • propel substances on cell surface
Flagellum • long tail-like projection • provides motility to sperm
10
Microfilaments and microtubules • thin rods and tubules • support cytoplasm • allows for movement of organelles
Cytoplasmic Organelles
11
Cell Nucleus
• control center of cell
• nuclear envelope • porous double membrane • separates nucleoplasm from cytoplasm
• nucleolus • dense collection of RNA and proteins • site of ribosome production
• chromatin • fibers of DNA and proteins • stores information for synthesis of proteins
12
Movements Into and
Out of the Cell Passive Transport
• require no cellular energy • simple diffusion •facilitated diffusion • osmosis • filtration
Active Transport • require cellular energy • endocytosis • exocytosis
13
Simple Diffusion
• movement of substances from regions of higher concentration to regions of lower concentration
• oxygen, carbon dioxide and lipid-soluble substances
14
Facilitated Diffusion
• diffusion across a membrane with the help of a channel or carrier molecule
• glucose and amino acids
15
Osmosis
• movement of water through a selectively permeable membrane from regions of higher concentration to regions of lower concentration
• water moves toward a higher concentration of solutes
16
Osmosis
Comparing the outside environment to the inside of the cell • if the outside solution has a lower solute concentration than it is hypertonic and the cell will swell
• if the outside solution has a higher solute concentration than it is hypotonic and the cell will shink
• if both environments are of the same concentration of solute they are considered isotonic and will remain stable
17
Active Transport
• carrier proteins transport substances across a membrane from regions of lower concentration to regions of higher concentration
• sugars, amino acids, sodium ions, potassium ions, etc.
18
Endocytosis
• cell engulfs a substance by forming a vesicle around the substance • three types
• pinocytosis – substance is mostly water • phagocytosis – substance is a solid • receptor-mediated endocytosis – requires the substance to bind to a membrane-bound receptor
19
Exocytosis
• reverse of endocytosis
• substances in a vesicle fuse with cell membrane
• contents released outside the cell
• EX: release of neurotransmitters from nerve cells
20
The Cell Cycle
• series of changes a cell undergoes from the time it forms until the time it divides
• 3 stages • interphase • mitosis • cytoplasmic division
21
Interphase
• very active period
• 2 phases
• G phases – cell grows and synthesizes new organelles to prepare for cytoplasmic division
• S phase – cell replicates DNA to prepare for nuclear division
22
Mitosis
• produces two daughter cells from an original somatic cell
• nucleus divides – karyokinesis
• cytoplasm divides – cytokinesis
• stages (PMAT)
• prophase – chromosomes form; nuclear envelope disappears • metaphase – chromosomes align midway between centrioles • anaphase – chromosomes separate and move to centrioles • telophase – chromatin forms; nuclear envelope forms
24
Tumors
Two types of tumors
• benign – usually remains
localized
• malignant – invasive and can
metastasize; cancerous
Two major types of genes
cause cancer
• oncogenes – activate other
genes that increase cell division
• tumor suppressor genes –
normally regulate mitosis; if
inactivated they are unable to
regulate mitosis
• cells are now known as
“immortal”
25
Stem and Progenitor Cells
Stem cell • can divide to form two new stem cells
• self-renewal • can divide to form a stem cell and a progenitor cell • totipotent – can give rise to every cell type • pluripotent – can give rise to a restricted number of cell types
Progenitor cell • committed cell • can divide to become any of a restricted number of cells • pluripotent
27
Clinical Application
Diseases at the Organelle Level
MELAS – mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes
• mitochondria are missing a gene necessary to carry out important energy producing reactions • usually inherited by mother • causes strokes, severe headaches, muscle weakness and numb hands
ALD – adrenoleukodystrophy • peroxisomes are missing enzymes • causes dizziness, weakness, darkening skin, and abnormal heart rhythms
Tay-Sachs Disease • lysosomes are abnormally large and lack one enzyme • causes nervous system failure and early death
top related