SPRINT-SARIShort Period Incidence Study of Severe Acute Respiratory InfectionMaya GeorgeMONASH UNIVERSITY

BackgroundMultiple outbreaks of novel SARI: Unpredictable events

H7N9, H5N1, SARS-CoV, MERS-CoV, 2009 H1N1 pandemic

critical to have the ability to collect and report data as quickly as possible during the next outbreak

ANZIC Influenza Investigators: address the gaps by providing a global platform for observational studies of patients with SARI as an essential component of pandemic and epidemic research preparedness

extend the concept to a range of acute infectious syndromes with epidemic or pandemic potential.

Increased RisksGlobalisation

Air travelFarming PracticesClimate Change

Objectives

UncertaintyWhen? Where?

How much critical illness?Age-specific incidence critical illness?

Risk factors for critical illness?Infectivity (R0)?

Case-fatality

Better prepared for informing clinicians & decision makers around the world

Improve healthcare systems to rapidly respond to infectious outbreaks

Research response capability for the future

Descriptive epidemiology and microbiology

Ethics, Administrative, Regultory and Logistic (EARL) barriers

ApproachTIERED DATA & SAMPLE COLLECTION:Modular and scalable standard Case Report Forms and integrated within the same Protocol

PERIODIC TESTING:5-7 day period during local peak flu season; annually

PREAPPROVED:Ethics approved and ready for immediate activation

Approach

Year1:Sitescollectthenenterdataretrospec3velyatany3metheylike,retrospec3veanalysis

Year2:Sitescollectthenenterdataretrospec3velyforapre-definedweek,retrospec3veanalysis

Year3:Sitescollect&enterdatainreal3meforapre-definedweek,retrospec3veanalysis

Year4:Sitescollect&enterdatainreal3meonimmediateno3ce,retrospec3veanalysis

Year5:Sitescollect&enterdatainreal3meonimmediateno3cewithreal-3medataanalysis&repor3ng

Time Increasin

gPan

demicRe

searchRespo

nsePrep

ared

ness

20162017

20182019

Testing protocol and CRFsTesting readiness

Value-adding

Pre-plannedPre-approved

Research Infrastructure

Towards Research Preparedness During Future Pandemics

An ethics-ready global network of sites capable of :

ü Collecting observational data during epidemic/pandemic;

ü Decreased lag time between outbreak onset and establishing an evidence base to guide ongoing decision-making;

ü Initiating appropriately designed time-sensitive research that will lead to improved care for patients during an outbreak.

Translation26 countries 140 sites 1500+ subjects

119

Global presence after 2.5 seasons

Translation

Acuteandcriticalcareresearchpreparednessforpandemics–theSPRINTprograms,andbeyond

Editorial Piece

Research Articles

• basedon 2016-2017SPRINT-SARIdata;• draftmanuscriptisbeingreviewedbytheworkinggroup.

Publication1

Publication2• basedon datafromimmediateactivationofSPRINT-SARIatalloursitesinNorth

America,andEuropeinJan/Feb2018duringthe“moderatelysevere”NorthernHemispherefluseason;

• Dataanalysiscurrentlyunderway.

Next steps

syndrome-specific CRF modules (either tiered or not tiered) for a range of different infectious syndromes

GenericCRFplusoneof:

SARITier1

SARITier2

SARITier3

Encephalitis GITier1

GITier2

SampleCollection

Demographic data, co-existing illnesses, timing of hospital +/- ICU admission, outcome data etc.

Modular CRF design: Extend the range of infectious syndromes that the protocol and CRF are suitable for

Contact Us:Lead investigators

§ Steve Webb, Monash University, Australia

§ Allen Cheng, Alfred Hospital, Australia

Project Manager

§ Maya George, Monash University, Australia

MNHS-Sprint.Sari@monash.edu