NIDA Director’s Report to the National Advisory Councils of

NIDA, NIAAA, & NCI

Nora D. Volkow, M.D., Director

February 4, 2015

0

200,000

400,000

600,000

800,000

1,000,000

1,200,000Budget Authority Appropriation in 1998 Dollars

NIDA Program Level in Appropriated Dollars and Constant 1998 Dollars

$ (

in t

hou

san

ds)

30% Budget is for AIDS research

NIDA Applications, Awards & Success Rates

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45

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Applications Awards Success Rate (%)

No. of

Ap

pli

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tion

s vs.

Aw

ard

s

Fiscal Year

%

%

%

%

%

%

%

%

%

%

0

10

20

30

40

50

60

91 92 93 94 95 96 97 98 99 00 01 02 03 04 05 06 07 08 09 10 11 12 13 14

Percentage of U.S. 12th Grade Students Reporting Past Month Use of

Cigarettes, Marijuana and Alcohol

SOURCE: University of Michigan, 2014 Monitoring the Future Study.

Cigarettes

Marijuana

Alcohol

Status of Marijuana Laws in the US

Nu

mb

ers

in M

illio

ns

3.1+ 3.1+ 3.2+ 3.4+

3.1+

3.6+ 3.9+

4.1+

4.6+ 5.0+

5.4

4.8+ 4.9+ 4.9+ 5.1+ 5.1+ 5.1+

5.5+

6.2+

6.9+ 7.1+

7.6

0

1

2

3

4

5

6

7

8

2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012

Marijuana on 20 or More Days in Past Month

Marijuana on 300 or More Days in Past Year

National Survey on Drug Use and Health (NSDUH)

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12

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90

Da

ily

Use

(P

erce

nt)

Per

ceiv

ed R

isk

(P

erce

nt)

Perceived Risk

Daily Use

Source: The Monitoring the Future study,

the University of Michigan

Monitoring the Future (MTF)

Regular Marijuana Use, Persons

Aged 12 or Older: 2002-2012

% 12th Graders Reporting Regular Marijuana Use vs. Perceived Risk of

Regular Marijuana Use

Source: National Survey on Drug Use and Health, SAMHSA

Subcortical Structures Differences Between Regular Marijuana Users and Nonusers

Weiland B J et al. J. Neurosci. 2015;35:1505-1512

Effects of Prenatal Nicotine Exposure on Brain Development in Boys and Girls

Chang et al, PING CONSORTIUM

Subcortical PC: NIC*Gender interaction p=0.017 (post-hoc interaction: left: p=0.17; right: p=0.68)

NIC exposed females had smaller GP than controls, males show no difference

Left and Right Pallidum

Vo

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e (

mm

3)

Age(years) V

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me

(m

m3)

Age(years)

2 4 6 8 10 12 14 16 18 20

2 4 6 8 10 12 14 16 18 20

Left Right

Adolescent Brain Cognitive Development National Longitudinal Study

Ten year longitudinal study of 10,000 children from age 10 to 20 years to assess effects of drugs on

individual brain development trajectories

NIDA, NIAAA, NCI, NICHD, NIMHD, ORWH, OBSSR, NIMH, NINDS, NEI

• Expert panel workshop developed recommendations on best

large-scale designs and measures to assess developmental effects

of substance exposure (beginning prior to exposure) during childhood

through adolescence (in human subjects) May 27-28, 2014

• RFI solicited input on proposed study design/measures

June-August 2014

• Revised design based on input from RFI and satellite symposium

at SfN November 17, 2014

• Notices of Intent to Publish: FOA January 2015

• Updates at: www.addictionresearch.nih.gov

Adolescent Brain & Cognitive Development (ABCD)

National Longitudinal Study NIDA NIAAA NCI NICHD NIMHD

ORWH NIMH NINDS OBSSR NEI

Time

Prospective cohort study of ~10,000 youth beginning ~ ages 9-10

Substance use, Cognition, Emotion, Mental Health, Physical health, Executive Function, General Intelligence, Environment, Biospecimens: Genetics, Epigenetics

Notice of Intent to Publish a Funding Opportunity Announcement for A Longitudinal Study of Adolescent Brain and Cognitive Development (ABCD) Research Sites (U01)

Notice Number: NOT-DA-15-001 Key Dates Release Date: November 26, 2014 Estimated Publication Date of Announcement: January 2015 First Estimated Application Due Date: April 2015 Earliest Estimated Award Date: September 2015 Earliest Estimated Start Date: September 2015 Related Announcements NOT-DA-15-002 NOT-DA-15-003 Issued by National Institute on Drug Abuse (NIDA) National Cancer Institute (NCI) National Institute on Alcohol Abuse and Alcoholism (NIAAA) Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

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Chalmers et al, Lancet 2014, 383, 9912, 11-17 How to increase value and reduce waste when research priorities are set

Pure basic research without consideration of relevance to

practical issues (Current 55%)

Waste

Pure applied research to address important practical

questions (35%)

Use-inspired basic research to address important practical

questions (Current 10%)

Low High

Relevant to immediate application

N Bohr

L Pasteur

T Edison

D E Stokes. Pasteur's quadrant—basic science and technological innovation. Brookings Institution Press, Washington, DC (1997)

NIDA Strategic Plan

2010-2015 Basic

Epi, Prevention Services (HIV)

Treatment (HIV)

CTN

IRP

RM&S

*30% Budget HIV/AIDS

Current/Future Issues • Leveraging new technologies • Developing standards, infrastructure, and tools to support Big Data • Integration with BRAIN Initiative • Responding to changes in SUD landscape (i.e., marijuana policies, healthcare reform, E-cigarettes as drug delivery devices) • Accelerate translation research (i.e., medications, devices) • Training for next generation of scientists

NIDA Strategic Plan 2010-2015

Input from multiple sources - NIDA staff, NIDA Advisory Council, Researchers,Practitioners, Constituent organizations, Consumer groups, Other Stakeholders • Key Mechanisms: - Request for Information (RFI)/Public Comment - Bold Goals Challenge Prizes - Priority Area/Cross - Cutting Work Groups • Publication: Fall 2015

Updating NIDA Strategic Plan • RFI released Dec 10 for feedback on draft priorities:

– Understanding basic science of drug use, addiction, vulnerability, and recovery

– Supporting development of new and better interventions and treatments

– Increasing the public health impact of NIDA research

– Enhancing the national research infrastructure

• Comment period closed January 30th (more than 200 comments)

• Next steps: – Priority Area Workgroups with internal and external experts:

• Big Data

• Gene x Environment x Development interactions

• Complex patients (multiple comorbidities) and phenotyping

• Health disparities

– Division strategic plans

• Timeline – RFI –Review – By March 6, 2015

– Priority Area Workgroups – Feb-July

– Division Strategic Plans Drafts – By February 6, 2015

– Draft Strategic Plan to Council – May 2015

– Final Strategic Plan – Fall 2015