Nanotechnology in Healthcare Sector

Feng Yang

A Perspective of Biosensors

Market Segmentation

Healthcare Sector

Pharmaceutical

Biotechnology

Clinical Diagnostics

Medical Devices

Medical Imaging

Patient Monitoring

Remote Patient Monitoring

mHealth

General Healthcare IT

Telemedicine

MedTech

Life Science

Connected Health

• Chronic diseases (diabetes and cancer) and infectious diseases will continue driving demand

for newer, better and targeted therapeutics;

• Innovative vaccine products, diagnostics and early detection of HPV, HIV, cancers,

Alzheimer’s decease and genetic deceases are strongly demanded;

• Molecular diagnostics, point-of-care testing and immunoassays are the fastest-growing areas;

• Dug and diagnostic co-development will accelerate M&A.

• Roche has dominated the self monitoring of

blood glucose (SMBG) sub-segment due to

its innovative products;

• The growth in capital equipment such as CT

and MRI scanners is driven by the

increasing number private hospital projects

(greenfield);

• Compared to the Western countries,

Cardiac rhythm management is a less

penetrated market in the Asia-Pacific area;

• Singapore reduced regulatory requirement

for Class A device dealer licensing and

provisioned for faster access and lower

regulatory fees for Class C and D medical

devices, which is expected to be replicated

in Malaysia;

• Electronic Medical Records (EMR) &

Electronic Health Records (EHR);

• Personalisation of Devices and Sensors for

Monitoring Physiological Parameters;

• Professional Solutions for Smartphones and

Personal Devices Assistants to Facilitate

Healthcare Mobility.

Source: Frost & Sullivan, 2013 APAC Healthcare Outlook, March 2014 : Potential market to focus for IMRE

Market Revenue for 2012

$64.78 B

CAGR for 2012 ~ 2016

10.2%

Market Size for 2016

$95.67 B

Degree of Technical

Change (scale of 1 to 10,

Low to High)

7.5

Base Year Market Growth

Rate

7.2%

Key Change

Increased Intelligence &

Diagnostics

Top 3 Vertical End Users

Process Control,

Automotive, Medical

Average Product

Development Period

2 years

Global Sensor Market Dynamics Huge Market Size

Sensor End-User

Market Analysis (2012)

Chemicals & Petro.

10.8%

Medical

9.9%

Process Control

7.7%

O&G

5.9%

Automotive

10.8%

Sensor Product Market

Analysis (2012)

Biosensors

13.2%

Flow Sensors

10.1%

Pressure

9.0%

Level Sensors

7.7%

Temperature

6.9%

Image Sensor

7.0%

Gas Sensors

4.2%

Source: Frost & Sullivan, Global Sensor Outlook 2013, June 2013

High Growth Rate of Biosensor Market

CAGR = 11.7% for 2012 - 2016

Biosensors

Vertical

Market

Market

Size

2012

($ Million)

Growth

Potential

Market

Size

2016

($ Million)

Research

Laboratory 1,005.5 Medium 1,539.1

Home

Diagnostics 1,790.3 High 2,919.0

Point of Care 4,259.4 High 6,469.8

Process

Industries 606.3 Medium 951.0

Environment 1,208.3 High 2,065.1

Biodefense 258.2 High 477.1

Total 9,128.4 High 14,421.2

Source: Frost & Sullivan, Global Sensor Outlook 2013, June 2013

Biosensors

Process

Industry

Defense

Environmental

Monitoring

Agriculture &

Food Safety

Pharmacology

Medicine

• High risk of diabetes and obesity;

• Rising incidence of chronic disease like heart

disease, stroke, cancer, chronic respiratory diseases,

tuberculosis etc;

• High concern of food safety.

Healthcare

Drivers:

• Development of nanotechnology;

• Multiple application;

• High demand of in-line monitoring.

Constraints

• Low technology transfer rate from lab to

commercial application;

• Vulnerable biomolecules are sensitive

to harsh environments;

• High R&D expenses (ave. $25 -30

million).

Nitto Denko Asia Technical

Centre (NAT)

Sensitive Element

Value Chain of Biosensor Development Process

Source: Kirsch, Jeffrey (2013) “Biosensor Technology: recent advances in threat

agent detection and medicine”, Chem. Soc. Rov.,42, pp.8733

IMRE IBN Nitto

Closed-Loop of Biosensor Development

Nanomedicine

Nanobiotechnology

Nanomachinary

Nanodevices

Gas Sensing

Polymer Sensing

Biological Sensing

……

NEMS*

To detect atom(s)

To detect biological molecules

(e.g. protein)

Nanomaterials:

CNT, NP, NW

Biological

Recognition

Interface

Integrated with

MEMS

A hypothetical approach to developing biosensors for medical application.

*NEMS: nano-electromechanical system

IMRE Staff Designation Capability Group

Dr. Wang, Zhijuan Scientist I

Synthesis & Integration Dr. Li, Jun Senior Scientist III

Dr. Zheng, Yuangang Scientist III

Dr. Liu, Rongrong Scientist I

Dr. O'Shea, Sean Principal Scientist I

Analysis &

Characterization

Ms. Khin Moh Moh Aung Senior Specialist I

Dr. Su, Xiaodi Senior Scientist II

Dr. Zhou, Xiaodong (Donna) Senior Scientist I

Ms. Zhang, Nan Senior Specialist I

Ms. Kanjanawarut, Roejarek Specialist II

Dr. Free, Paul Francis Scientist I

Dr. Tan, Yennee Scientist III

Research Staff of IMRE in

Biosensors-Related Area Glucose

31.6%

Cardiac Biomarkers

7.4%

Infectious Disease

5.8%

Toxicity

8.8%

Biosensor End-User Application (2012)

Source: Frost & Sullivan, Global Sensor Outlook 2013, June 2013

0 625 1250 1875 2500

Carbon Nanotube (CNT)

Nanoparticles (NP)

Quantum Dot (QD)

Graphene

Chitosan

Dendrimer

Lipid / Liposome

Nanofiber

No. of Publication

21%

36% 8%

16%

9%

2% 6%

2%

14%

39%

16%

20%

1% 1%

4% 5%

Carbon Nanotube (CNT) Nanoparticle

Quantum Dot Graphene

Chitosan Dendrimer

Lipid / Liposome Nanofiber

Research Publication of IMRE on

Biosensors

• Title + Key word + Abstract: (biosensor OR nanosensor)

AND nanomaterials

• Year: 2010 - 2014

• Database: Scopus

IMRE

Worldwide

Research Publication of IMRE on

Biosensors

45%

25%

16%

5%

4% 3% 2%

Nanyang Technological University

National University of Singapore

Institute of Microelectronics

Institute of Materials Research and Engineering

Institute of Bioengineering and Nanotechnology

Yong Look Lin School of Medicine

Singapore INstitute of Manufacturing Technology

Collaborative Publication of IMRE on Biosensors (2010-2014)

NTU

NUS

IME

54%

7%

7%

7%

7%

7%

4% 4% 4%

Singapore AustriaChina IndiaThailand USGermany New Zealand

Research Publication on Biosensors in Singapore (2010-2014)

SG

AT

CN

IN

TH

US

Summary

1.Medical devices, medical imaging, biotechnology and clinical

diagnostics can be the research focus for IMRE to make its

impact on healthcare sector;

2.There’s a great market for sensors in the medical application,

while biosensors have the largest market revenue.

3.Biosensors have high growth potential in research laboratory,

home diagnostics and point-of-care of healthcare sector.

4.NAT has demonstrated a successful collaborative mechanism

between IMRE and Nitto Denko in terms of the value chain of

biosensor development process.

4.A closed-loop approach has been proposed in the development of

NEMS-based bionanosensors for IMRE in order to strengthen

IMRE’s impact on the R&D value chain.

5. The statistic result of IMRE’s research publication shows that

IMRE shares the same research interest with global statistics in

terms of nanomaterials research for biosensors application.

6.IMRE is suggested to seek more collaboration with NTU to rely on

its research strength in biosensors in the local context as well as

more and broader alliance with overseas institutes.

7.A further study on the patent of biosensors with benchmarking

global peers is expected to position IMRE’s capability in the

technology transfer map of this area.

Summary