SABITHA.K II M.PHARM Dept:PHARMACEUTICS

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Introduction Advantages Limitations Mechanism Applications Objective of the work Plan of work literature review

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Nanoparticles are solid colloidal particles with diameters ranging from 1-1000 nm.

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Nanoparticle consist of macromolecular materials in which the active ingredient is dissolved, entrapped, encapsulated, adsorbed or chemically attached. Polymers used for nanoparticle drug delivery system include natural polymers and synthetic polymers

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Natural polymers: Chitosan Alginate Gelatin

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ynthetic polymers: Poly(lactide-co-glycolide) Poly lactic acid Polyhexylcyanoacrylate

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Particle size and surface characteristics of nanoparticles can easily manipulated Control and sustain release of drugs there by increasing the drug therapeutic efficiency Reduction in side effects and toxicity Site specific targeting Improved stability of drug

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Small size and large surface area leads to particleparticle aggregation. Small size and large surface area result in limited drug loading and burst release.

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Diffusion Erosion

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chemotherapy Intracellular targeting In gene delivery In ocular drug delivery Delivery of proteins and peptides For brain targeting

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To prepare and optimize a passive carrier using a natural polymer chitosan for the ocular delivery of moxifloxacin and thus increase its transient residence time & bioavailability To evaluate its physico-chemical characteristics, in vitro release and stability of the drug loaded nanospheres

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Pre-formulation studies: Solubility studies U V calibration data IR Spectroscopy Process optimization

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Formulation Evaluation

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Physico-chemical characterization:o o particle size and zeta potential particle morphology

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Drug entrapment In vitro drug release Microbiological studies In vivo study Mucoadhesion studies Stability studies

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Sanjay.k. Motwani; have studied chitosan-sodium alginate nanoparticles as submicroscopic reservoirs for ocular delivery:formulation,optimisation and invitro characterization . ejpb 68,2008. Azza A Mahmoud; have studied chitosansulfobutylether--cyclodextrin nanoparticles as a potential approach for ocular delivery. ijps 413,2011

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Basavaraj K Nanjwade;have studied praparation and evaluation of carboplatin biodegradable polymeric nanoparticles. ijps 385,2010 Marta Merodio; have studied ganciclovir loaded albumin nanoparticles;characterization and in vitro release properties. ejps 12;2009 Robhash Kusam Subedi;have studied preparation and characterization of solid lipid nanoparticles loaded with doxorubicin. ejps 37;2009