logy course 4

8/14/2019 logy Course 4

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CIII.O\IC Nr LArlMA llo,.. Lotrr. i

tlistolog ca featJrer of cl ro,rr( i1!a-matof locLs. ri.ontai 10 A (vasuhr

ymphoqiesandpasm:.es'

(cl RePa r or nlur ss is made by(anq'osenesis-and ibi.r6 9(d) h4 ns and snids rissu.

Chronic inflammalion. lt is an inflammation of long-term (weeks,months), in which jl occurs simultaneoLtslyl- active inflammai on- tissue damage,- repaif pfocesses.. Chronic inflammation may be a resull of

acute inflammation, but often, chronicinflammation starts insidiously.

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Types of chronic inflammation

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Non-spec llc chronic infam.nat on ischaraclerized by a focal or diffuseInfl Emmatory infittraie composed of- Ex.. innammaion from.hrcn c peptr. ukerfiomspecific chron c inftammat on. it rscnaractelzed by lesions specifc to a-Ex


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nnamm.r on is charaDterized by

Ex chron c pepl c u cer ross or

cir o,r c nflarnmatton\lon spec i c

Varicose ulcer


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Granulomatous chronic inflammation (lCG)

. aggr6qat6 ol aol,Eledmajnry lyhphodyl4 (1y)


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Classification of granulomas based on themechanism of production. immune type (immune mechanism)

- caseous; ex. Tuberculosis- non- caseous; ex. Sarcoidoss. non-rmmune type:- ex. foreign body granulomas

Etiological classifi cation ofgranutoamas

. Koch bacillus "tuberculosis. treoonema !allidum . svohiLis. BGP (actindmyces lsra;ii) . actjnomicosis. BGN -catscratch disease- The pahsite (toxoplasma Gondi) - toioplasmosis- Fungi (candida arbicans) " candidiasis

lll, the unknown aetiology:


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_iubercul.:iucinflammalion

rubercu oussranu oma {rB) wh'ch

l\4acroscopic types of tuberculous lesions

Nodulaf lesionsDiffuse lesions

L

Itl

(tubercles)

Ulcefated lesions


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.i.

Nodular lesion


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Nodura, iesions (tbercret

Nodular lesions

Poly.yclelubetle. lbcboncliopne!mnla

Pulmonary tuberculous nodule


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Nodular lesions = milliary tubercles


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Nodular lesions = milliary tubercles

Polycycle tubercles

10


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Noduiar rena tubefcLl oslsand ulcerative renal tuberculosls

Difusse lesionsln pafenchymalorgans:

Pulmonary apical 1!berculous infillrate- Caseous pneunroniaOn Serols sufaces:-tuberc!lous Pertonilis- tubercurous p eures a

tuberculoLrs lePtomen ngltis


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Ulcerative lesionsLn the caviiary organs or suriaces:-Tbculceratons(cutaneous iniestna)ln parenchyrnal organs - cavemae:

Renal ulcerative tuberculosis

O'ssem,nalon Mys ofrubercu ou5 infectiondnd ennsion of a mosl close/sl3p bystep/c ose to closeTnear by nearllynphaicmy'specmcway iiIobercurous pdma.ry nfecriodh-"marosenous My (b Kocheniers nlhe

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Acqurreo sYPirilisStage I

Syphilitic inflammation

tl


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Stage ll F;si

\lrtri\\Cutaneous-mucous leslons

Ski.les onste seconorashes ilrat mav nave avar ely of appearances

papub, les cns;syprrl dete q condylomalala rfom

The rash often appearsas red or feddish brownsools both on the Pahsolihe hands and on the

lesLons[4ridIcandcela

Se|o og ca dragnosrs rsmonihs w tholt neaLngwth or wthout treatmeft


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Tertiary or Late SyphilisStagesrao llao@areto5r01sv*is f.om th healinq offfiaiion of leriiary ls onsmefrb.anes and oeep otgans0tr, b@n bon, heanand

Gumma is a o zed area ofcharadtetsl c nllamnatory

m msumma 1m'u6.op d

ltlrh. rarent (hidd'n) shqe ot

wibourr.ahenq $e inraded

t5


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Gummadld!iiglkh.lodof'pii|i!. ;;;"-r, ; -."'.",*,"u,'J.ffI",*. *.* " " ""'. '"io vidr 6n o*cbrcv (d' ordsbd)a, ::gtiiltisitrr$i: fiiirulfrv$*\i'll,lilf

(3) *Hii*.*Strg;"1?$*fi l,i3*i#*r3**',s,'r;]:lfjj"',t'$:1l.{4) Fi&di. 4nnc qrcslod b ! redabt nuiht $45

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Congenital sYPhilisLranem *rcn rrm moiherro tbe letnestm. *dd e nose debnryIhe (onsen la nphr s.ouLd beeadYorr.te

'e ts 'ooq a ab'o n: ire

ActinomycosisBGP (actinomYces lsraeli)Actinomycosis (A) is a bacte alinflammation produced by actlnomycesIsraeli. a qram positive, anaefoDlc,filamentoils bacteria (BGP), that ls asaprophyt in the o|al cavity and checumBacteria enters into the adjacent softtissues, using a solutio"'l of contin.lity ardprod,Jces a chrot'c purulent irflam'natlonand fistula.


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Actinomycosis-AMacfoscopically, A is

fistule which drains asyelow granules (thecolor of the sulPhur

ActinomycosisM croscopnany actLnomycos'sis a drron csuPUEtron vnrh

On a rilstolog 6l *diion oi thepurue^loiuere.*ea 3puruentetudale made up oraltered and ntnse basoplr rD

ye low gra.ules (the colorol


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Cat scratch disease-CSDCSD s a. inflammaironnegaiive bacteria (BGN)sc.aich, whLch produces.nammation drarnina in

lyriph nodes whrdr are

Cat scratch disease-CSDMicroscopically itdeverops

GEnulonauft bndency losupuraton h @opdsed of Ecsupr?fveaLAa appet n9 as aDu,uent siar (sranuLoma wit[


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Helminthiasis. ls an inflammation caused bYhe minthvworms as a reactionlothetissue incLusion orrcm |6Nae:' cvElicec (dEease=cvslicetcosis), laryaorienia solium is localEed h periskeletonsofltissues or in the braLn. hydalic c'st (dFease=hvdal dosis) .lhelada ol Ech nococcls qranulGu3, wncrLocales in the liver, lung, hearl, kidnev6

2l


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Disease=cysticercosist larva=cysticerc

Hydatic cystMacroscopically hydaliccyst js a cysljclesion orvaiable size (5-10 cm),

. an exienalnbrcus

. an internalwa I-the germlnallayef

2)


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Foreign body granulomaForeign body qranu oma 3$ean und'cested iorc qn bdyThe thre reaclron 's a chronicnon-ncrot c gnuLomatousGEnd oma is composed ot

nodueorvdousdmension

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Foreign body granuloma- Lipogranuloma -

Lioooranuoma s produced as reaciron agaL.sIendcellula r llplds acc!mu!ated aier a liss!e lra!masomelimes, areJormed n lhe aa otmammary g andand are looking as pseudo_tumora masses

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5a rcoidosis

Crohn's disease

logy course 4

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