life science for health and innovation time to transform sten g e lindahl karolinska institutet
DESCRIPTION
Life Science for Health and Innovation Time to Transform Sten G E Lindahl Karolinska Institutet Karolinska University Hospital Stockholm, Sweden. Fosbury Flop. Western Roll. Scissors. Incremental or Quantum Leaps ?. Olympic Gold Medal Winners in High Jump. 2.6 2.4 2.2 2 1.8 - PowerPoint PPT PresentationTRANSCRIPT
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Life Science for
Health and Innovation
Time to Transform
Sten G E LindahlKarolinska Institutet
Karolinska University HospitalStockholm, Sweden
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William F. Achtmeyer Center for Global Leadership - Tuck School of Business at Dartmouth
Incremental or Quantum Leaps?
2.6
2.4
2.2
2
1.8
1.6 1900 1920 1940 1960 1980
Scissors
WesternRoll
Straddle
FosburyFlop
Source: Pascale
Olympic Gold Medal Winners in High Jump
Quantum Leap
Incremental
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1950 1965 1980 1995 2010
Molecular Biology towards Molecular and Regenerative Medicine
Quantum Leap
Incremental
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Pathogenetic mechanisms and Phenotypes
Genetic Initiators
Individualized
Preventive
Prognostic
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Research
Innovation
Knowledge Triangle
Growth & Jobs
Creative sector
Education
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Challenges
Collaborative research
Joint Technology Initiativessuch as medicines,nanoelectronics aso
International cooperation
Systems
Univ - Univ Hosp&
Society/Industry
Intellectual Property &
Biotechnology
Partnerships
Clusters
More integration than before
Universities- Long term research- Frontier research
Capacity building- infrastructure
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Outline
Life Science & Modern Health Care
Scientific questions
Public and Private
Transforming
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Life Science &
Modern Health Care
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Medical Research
Basic Medical Science
Clinical Science/Clinical testing
Implementation in Clinical Practice
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Natural Sciences
Physics
Chemistry
Medicine
Biology
Mathematics
Technology
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Current clinical subjectsCurrent clinical subjects
Entireity or Fragmentation?Entireity or Fragmentation?
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Brilliant individuals Brilliant systems
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Advantages – Enhanced Potentials
Create an Internal Market for Research
Research better funded
Diminish Fragmentation
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- Chamber of Commerce, Milano, Italien - One Nucleus, London-Cambridge, Storbritannien - Heidelberg Technology Park, Heidelberg, Tyskland - INNOVA, Debrecen, Ungern - Medicen, Paris, Frankrike - Matimop, Tel Aviv, Israel - Alsace Biovalley, Alsace, Frankrike - Bioindustry Park Silvano Fumero, bioPmed innovation cluster, Torino, Italien - Barcelona Science Park, Barcelona, Spanien - BioWin, Vallonien, Belgien - Medicon Valley Alliance, Medicon Valley, Danmark-Sverige - BioM Biotech Cluster Development, Munchen, Tyskland - Stockholm Science City, Stockholm, Sverige
www.toolsofscience.eu
www.stockholm-life.se
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Searching
Common Denominators
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Future Medicine based onScience and Development
Would Pathogenetic mechanisms be the logical denominator?
If so, are todays clinical departments based on pathogenetic mechanisms?
If not, what then??
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Clusters
Cardiovascular-Diabetes-Kidney
Cancer-Hematology
Infection-Inflammation-Immunology
Neuroscience-Psychiatry
Regenerative/Reparative Medicine
Reproduction & Developmental Medicine
Endocrinology & Metabolism
Cardiovascular-Diabetes-Kidney
Cancer-Hematology
Infection-Inflammation-Immunology
Neuroscience-Psychiatry
Regenerative/Reparative Medicine
Reproduction & Developmental Medicine
Endocrinology & Metabolism
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Will a ThrivingHigh performance organisation be Vertical or Horizontal?
or Both ??
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The Scientific Question
Einsteins challenge(but not Bohrs)
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ACß3
cAMP
PK
acyl-CoA FFA
acyl-carn
acyl-CoA ß-oxidation CAC
ATP
respiratorychain
proton circuit
H+
cell membrane
NE
HSL
thermogenin
mitochondrial membrane
ß3
lipiddroplet
Proton gradient across Mitochondrial Membranes
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Biomechanics from
macro- to nano-scale
When will we be able to image/visualize a turn of the spiral ?
1 nanometer, nm, is 1 billionth of a meter
1 atom = 0.1nm; 1 turn of the DNA-spiral is 3.4 nm
Nanotechnology 2015 2 million jobs ;10 billion €
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Public and Private
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The Boston Globe
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Trust in Research
Weakening trust for researchers in western regions (around 50%).
It may be comforting that the figure for Medical researchers was 77%.
A leading traditional university can no longer state:
”?? is not obliged to compete. There are no challengers perpetually ready to depose ?? from its pre-eminent position”
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Universities are being challenged
There is a Competition
Ranking and Metrics
To Measure and Be Measured
To Change – But How?
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The University as a Marketplace
A University cannot be run by cost accountants
or
Act as a commercial enterprise responding only to changing markets.
That is bad for academies and the societies we seek to serve. Henry Rosovsky,
The University, W W Norton and Company, 1991
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Competing logicsDifferent levels of Partnerships
Managerialism & Professionalism
Knowledge transfer
Academia & Commercialism
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A Partnership is a Partnership is a Partnership
Academic Medical Centers (mergers are high risk)
Universities (LoI or MoU)
Public and Private (open innovation)
Departments
Research groups
Individuals
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Competing logics
Different levels of Partnerships
Managerialism & Professionalism
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Competing logicsDifferent levels of Partnerships
Managerialism & Professionalism
Knowledge transfer
Academia & Commercialism
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Research
Health CareEducation
Knowledge triangle
Academic Health Centers
Knowledge Transfer
Investments
Economics
Innovation
Growth & Jobs
Society
PatentsPublications
People
ContractsNetworkingStart-ups
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New Knowledge
Talents
Academy
Using money
Earning moneyTeaching
Hiring
Knowledge Transfer
CommercialismAcademy
Commercialism
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Transforming Doubt, Develop and Change
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Transforming
Challenges in the North
Neurodegenerative diseasesCancerCardio-Vascular and HypertensionDiabetetsThe Metabolic SyndromeStress and Psychiatric conditions
Challenges in the South:
Nutrition and PovertyGastrointestinal diseases and DiarreaHIV/AIDSMalaria-Polio-TuberculosisFamilyplanningTobacco and Nicotin
The Art of Maintaining Wellness
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Leadership
Measurements
Change
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Development:the driving forceComte and SpencerDarwin and Haeckel
The philosophicaldoubtDescartes and Spinoza
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To Measure & To Be Measured
Own Other
High Performance
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To Measure
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Siegmund Freud to Stefan Zweig:"Up to now I have considered surrealists………..as incurable nutcases. The young Spaniard, however,……. has made me reconsider….. In fact, it would be very interesting to investigate the way in which such a painting has been composed."
Metamorphosis of Narcissus
To be Measured
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Change
Development:the driving forceComte and SpencerDarwin and Haeckel
The philosophicaldoubtDescartes and Spinoza
The enemy of Status Quo
Innovation/Development/Change
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Life Sci&
Modern Health
Care
Summing up
CreativityFantasy
Public and Private
Transforming
Scientific questions