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ANTIBIOTIKAANTIBIOTIKA

Dr.I.B.NGURAH,M.ForDr.I.B.NGURAH,M.For

BAGIAN FARMAKOLOGI FKBAGIAN FARMAKOLOGI FKUNUDUNUD

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PendahuluanPendahuluan

Fleming, peniillin, !"#$Fleming, peniillin, !"#$

!"%#!"%#

An&i'io&i(a 'er(em'ang pe)a&An&i'io&i(a 'er(em'ang pe)a&

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Ba(&erio)&a&i(Ba(&erio)&a&i(

Ba(&eri)idBa(&eri)id

Kadar ham'a& minimalKadar ham'a& minimal Po)& an&i'io&i e*e&Po)& an&i'io&i e*e&

+pe(&rum lua) on&oh- e&ra/lin0+pe(&rum lua) on&oh- e&ra/lin0

+pe(&rum )empi& on&oh+pe(&rum )empi& on&oher/&hrom/in0er/&hrom/in0

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ANTIBIOTIKAANTIBIOTIKA

PENICILLINPENICILLIN

B1N23L P1NI4ILLINB1N23L P1NI4ILLIN

B1N2AHIN1 P1NI4ILLIN GB1N2AHIN1 P1NI4ILLIN G

P1NI4ILLIN 5P1NI4ILLIN 5AMPI4ILLIN, AMO6I4ILLINAMPI4ILLIN, AMO6I4ILLIN

P1NI4ILLIN UNUK P+1UDOMONA+P1NI4ILLIN UNUK P+1UDOMONA+

  KL1B+I1LA  KL1B+I1LA  PRO1U+PRO1U+

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4ARB1NI4ILLIN4ARB1NI4ILLIN

 I4AR4ILLIN I4AR4ILLIN

P1NI4ILLIN AHAN P1NI+ILINA+1P1NI4ILLIN AHAN P1NI+ILINA+1

O6A4ILLINO6A4ILLIN

DI4LO6A4ILLINDI4LO6A4ILLIN

NAF4ILLINNAF4ILLIN

M1HI4ILLINM1HI4ILLIN

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MEKANISME KERJAMEKANISME KERJA

SPEKTRUMSPEKTRUM

RESISTENSIRESISTENSIESOESO

INDIKASI KLINIS,KONTRA INDIKASIINDIKASI KLINIS,KONTRA INDIKASI

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SULFONAMIDESULFONAMIDE

M1KANI+M1 K1R7AM1KANI+M1 K1R7A  PABAPABA

  +ULFONAMID1+ULFONAMID1

  DIHIDROFOLADIHIDROFOLA

  RIM1HOPRIM RIM1HOPRIM

  1RAHIDROFOLA 1RAHIDROFOLA

 

+IN1+A RNA DAN DNA+IN1+A RNA DAN DNA 

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MACAM-MACAM SULFONAMIDEMACAM-MACAM SULFONAMIDE

(LIHAT DIKTAT)(LIHAT DIKTAT)

FARMAKOKIN1IK FARMAKOKIN1IK 

K1RN8I41RU+K1RN8I41RU+

1+O1+O INDIKA+I KLINI+INDIKA+I KLINI+

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CHLORAMPHENICOLCHLORAMPHENICOL

D1RI5AN3A HIAMPH1NI4OLD1RI5AN3A HIAMPH1NI4OL P1RB1DAAN D1NGAN 4HLORAMPH1NI4OLP1RB1DAAN D1NGAN 4HLORAMPH1NI4OL

FARMAKOKIN1IK FARMAKOKIN1IK 

M1KANI+M1 K1R7AM1KANI+M1 K1R7A

+P1KRUM+P1KRUM

R1+I+1N+IR1+I+1N+I

1+O1+O

INDIKA+I KILINIK INDIKA+I KILINIK 

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MACROLIDEMACROLIDE

ERYTHROMYCINERYTHROMYCIN

SPIRAMYCINSPIRAMYCIN

CHLARITHROMYCINCHLARITHROMYCIN  AZITHROMYCINAZITHROMYCIN

  ROXITHROMYCINROXITHROMYCIN

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FARMAKOKINETIKFARMAKOKINETIK

MEKANISME KERJAMEKANISME KERJA

SPEKTRUMSPEKTRUM RESISTENSIRESISTENSI

ESOESO

INDIKASI KLINIS, KONTRA INDIKASIINDIKASI KLINIS, KONTRA INDIKASI

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BEDA ERYTHROMYCINBEDA ERYTHROMYCIN

  SPIRAMYCINSPIRAMYCIN

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TETRACYCLINTETRACYCLIN

FARMAKOKINETIK FARMAKOKINETIK  MEKANISME KERJAMEKANISME KERJA SPEKTRUMSPEKTRUM

RESISTENSIRESISTENSI ESOESO INDIKASI KLINIK, KONTRA INDIKASIINDIKASI KLINIK, KONTRA INDIKASI

BEDA DENGAN DOXYCYCLIN,BEDA DENGAN DOXYCYCLIN,MINOCYCLINMINOCYCLIN

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Penggunaan an&i'io&i(a pada (ehamilanPenggunaan an&i'io&i(a pada (ehamilan

Peniillin, er/&hrom/in, ephalo)porinPeniillin, er/&hrom/in, ephalo)porin

Aminogl/o)ideAminogl/o)ide

+ul9onamide+ul9onamide

4hlorampheniol4hlorampheniol

:uinolone:uinolone

 e&ra/lin e&ra/lin