iv] the nervous sytem
DESCRIPTION
dendrites receptors of stimuli 1 body of cell source of ions 2 3 nucleus source of proteins eg. pumps 4 Schwann cells fats that insulate the neuron 5 Nodes of Ranvier gaps in the insulation 6 axon path of electrical signalTRANSCRIPT
IV] THE NERVOUS SYTEM
1
2
3
4
5
6
dendrites
body of cell
nucleus
Schwann cells
Nodes of Ranvier
axon
receptors of stimuli
source of ions
source of proteins eg. pumps
fats that insulate the neuron
gaps in the insulation
path of electrical signal
1. Dendrite
3. Nucleus
2. Cell body
4. Schwann cells
5. Nodes of Ranvier
6. Axon
7. Axon Terminal
8. Terminal Bouton
9. Axon Hillock
K+ K+
K+ K+
K+ K+
K+ K+
Na+ Na+
K+ gate
Na+ Na+
Na+ Na+
Na+
Na+ Na+
Na+
Na+ gate
Na/K pump
inside of neuron
outside of neuron
1. The Na/K pump - pumps 2 K+ in and 3 Na+ out of the neuron
2. The K+ gate - allows K+ to freely move out of neuron
3. The Na+ gate - usually these are partly closed, and so only allows some of Na+ to move back into neuron
4. The result
- there are more Na+ ions outside of neuron which gives it a positive charge outside
- because there are Cl- ions equally inside and out, the inside of the neuron now has a negative charge after some of the Na+ ions have moved outside
- the net result is a -70 mV negative charge inside the neuron compared to outside
A. Resting potential
B. Stimulus
Na+
Na+
C. Propagating signal
Na+
Na+
Na+
Na+
D. Further propagation of signal
Na+
Na+
Na+
Na+
4. ACTION POTENTIAL
+40 mV
0 mV
-70 mV
MILLISECONDS
A. RESTING POTENTIAL
B. DEPOLARIZING
C. REPOLARIZING
D. HYPERPOLARIZATION A
E. REFRACTORY PERIOD
A. RESTING POTENTIAL - the Na/K pumps are ON
- Na+ gates are CLOSED
B. DEPOLARIZING - the Na/K pumps are OFF
- the Na+ gates are OPEN
C. REPOLARIZING - the Na/K pumps are ON
- the Na+ gates are CLOSED
4. ACTION POTENTIAL
D. HYPERPOLARIZATION - the Na/K pumps are ON
- the Na+ gates are CLOSED
- extra positive ions are pumped out, making a larger electrical difference
E. REFRACTORY PERIOD
- the time during which the neuron can NOT respond to a new signal
F. THRESHHOLD VALUES
- a neuron is either ON or OFF, there are no part signals
- a stronger stimulus results in the sending of MORE signals
-if a stimulus does not reach the threshold level, the neuron isnot activated
or more neuron sending the same signals
5. SALTATORY CONDUCTION - in mylenated cells
A. RESTING POTENTIAL
B. STIMULUS
Na+
Na+
C. PROPAGATING THE SIGNAL
Na+
Na+ Na+
Na+
D. FURTHER PROPAGATION OF SIGNAL
Na+
Na+
Na+
Na+
mylenated neurons send the signal faster as the signal jumps under the Schwann cells
thicker neurons have more pumps and more ions and so they can depolarize and repolarize faster
Synapses between neurons
Ca2+
Ca2+
axon dendrite
synaptic cleft
6. PROPAGATING A SIGNAL ACROSS A SYNAPSE
1
Ca2+2
Ca2+
2axon
1. INCOMING ELECTRICAL SIGNAL-arrives at the axon end of the synapse
2. CALCIUM CHANNELS -are triggered to open and let Ca2+ ions enter the axon
3. PRE-SYNAPTIC VESICLES
-the Ca2+ causes pre-synaptic vesicles to move to the end of the axon
3
4
6
7dendrite
synaptic cleft
4. NEUROTRANSMITTER
-the pre-synaptic vesicles release neurotransmitter [acetylcholine] into the synaptic cleft [space]
5. RECEPTORS -the neurotransmitter binds to receptors in the dendrite
6. OUTGOING ELECTRICAL SIGNAL
-the neurotransmitter / receptor complex [N/R complex]initiates an electrical signal in the dendrite
7. ENZYME
- an enzyme [acetylcholinesterase] is released from the dendrite to get rid of acetylcholine and stop the N / R complex from initiating another electrical signal
5
neurotransmitter
location function
ACETYLCHOLINE nerve / muscle synapses
responsible for muscle contractions
SEROTONIN in brain synapsesrole in emotions such as depression, aggression, impulsive behaviour
NOREPINEPHRINE in brain synapses role in dreaming, arousal, moodiness
BETA-ENDORPHINS & ENKEPHALINS in all synapses
modifies nerve signals eg reduces pain sensitivity
DOPAMINE in brain synapses affects control of movement, emotions, pleasure , pain
GLYCINE & GABA
in brain synapses inhibit signals
GLUTAMINE in brain synapses
most commoninvolved in memory
too much kills brain cells
mylenation proceeds from the back to the front as you age
Now work on…………
“Problems with neurons”