introduction to autonomic pharmacology part ii - anatomy of
TRANSCRIPT
INTRODUCTION TO AUTONOMIC PHARMACOLOGY: Part II
Anatomy of peripheral nervous system
SkeletalMuscle
Peripheral Nervous System
Somatic NervousSystem
Autonomic NervousSystem
ParasympatheticNervous System
SympatheticNervous System
SelectiveActivation
DiffuseActivation
Glands, Smooth Muscle& Cardiac Muscle
Controls skeletal muscle
Controls smooth & cardiac
muscle & glands
Peripheral Nervous System
SomaticNervousSystem
AutonomicNervous System
One NeuronEfferent
Limb
Two NeuronEfferent
Limb
Ach
Ach
Ach
Ach NE
AchEPI/NE
Ach Ach
Somatic
Sympathetic
Sympathetic
Sympathetic
Para-sympathetic
Postganglionic Fiber; Adrenergic
Pos
tgan
gli o
ni c
F
ibe r
; C
ho l
i ner
g ic
Adrenal Gland
Motor Fiber
Sweat Glands
Smooth MuscleCardiac CellsGland Cells
Smooth MuscleCardiac CellsGland Cells
Skeletal Muscle
Pr e
g an
glio
nic
Fib
e r;
Ch
o lin
e rgi
c
Ganglion
Ganglion
Ganglion
Radial Muscle of IrisCiliary Muscle
SA & AV NodesHis-Purkinje System
Myocardium
Bronchi/Bronchial Glands
Stomach
Kidneys
Intestines
Bladder//Genitalia
Sublingual/Submaxillary & Parotid Gland
Pilomotor MusclesSweat Glands
Blood Vessels
Sympathetic Nervous System(Thoracolumbar Outflow)
Paravertebral Ganglia
Prevertebral Ganglia
Ventral Root
White Ramus Communicans
ParavertebralGanglion
PrevertebralGanglion
Gray Ramus Communicans
AutonomicNerve
SpinalNerve
Epinephrine
(+) Fatty Acid Release (-) Intestinal Motility
(+) Glycogenolysis
(+) ACTH & TSH
(+) Mental Alertness
(+) Muscle Contraction & Efficiency
(+) Dilates Airways
(+) Cardiac Output
ADRENAL MEDULLA
Chromaffin Cells
Parasympathetic Nervous System (Craniosacral Outflow)
Genitalia
Bladder
Large Intestines
Kidney
Bile DuctsGallbladder
Small Intestines
Stomach
Bronchi/Bronchial Glands
SA & AV Node
Sphincter Muscle of IrisCiliary Muscle
Lacrimal Gland
Submaxillary &Sublingual
Glands
Parotid Gland
Most organs receive dual sympatheticand parasympathetic innervation.
However, some organs only receivesympathetic innervation:
SpleenSweat Glands
Piloerector MusclesMost Blood Vessels