ans pharmacology -introduction | review of the autonomic nervous system

8/15/2019 ANS Pharmacology -Introduction | Review of the Autonomic Nervous System

1/79


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3/79

Jcri Njgftlp Ircy, J.E.

Ufpnis Fut`nal

9

Gfjlfstcsns

Mcsni Alurfcactfjy cae Alurfpgysnf`foy fb CAY

Alurftrcasjnttlrs

]lilptfrs

]lilptfr-@nocae Natlrcitnfas & Ynoac` Urcaseuitnfa

Cutfafjni cae Yfjctni [gcrjcif`foy Ulrjnaf`foy


4/79


5/79


Cutfafjni Alrvfus Yystlj (CAY)

<

Cutfafjni alrvfus systlj (CAY) ns pcrt fbalrvfus systlj rlspfasnm`l bfr gfjlfstcsns

Lxilpt bfr sdl`ltc` jusi`l, wgnig olts ntsnaalrvctnfa brfj sfjctfjftfr alrvfus systlj,naalrvctnfa tf c`` ftglr frocas ns supp`nle my CAY


6/79


CAY vs. Laefirnal Yystlj naGfjlfstcsns

2

Cutfafjni alrvfus systlj (CAY) ns jfjlat-tf-jfjlatrlou`ctfr fb natlrac` lavnrfajlat rlou`ctnao splinbni buaitnfas

tgct fiiur wntgfut ifasinfus ifatrf`8 rlspnrctnfa inriu`ctnfa enolstnfa mfey tljplrcturl jltcmf`nsj swlctnao, slirltnfas fb ilrtcna laefirnal o`caes

Laefirnal systlj, na ifatrcst , prfvnels s`fwlr, jfrlolalrc`nzle rlou`ctnfa my slirltnao gfrjfals natf tgl systljniinriu`ctnfa tf cit ct enstcat, wnelsprlce sntls fvlr plrnfes fb

jnautls tf gfurs tf ecys


7/79Jcri Njgftlp Ircy, J.E.

CAY cae Laefirnal YystljTifjjfa prfplrtnlsZ

?

gnog-`lvl` natlorctnfa na tgl mrcna

cmn`nty tf nab`ulail prfilssls na enstcat

rlonfas fb mfey

lxtlasnvl usl fb aloctnvl bllemcid

jcnatcnanao gfjlfstcsns

mftg systljs usl igljnic`s bfrtrcasjnssnfa fb nabfrjctnfa


8/79


9/79



Gfjlfstcsns (=)

3;

C eyacjni stlcey stctl fb ifastntulats na natlrac`

lavnrfajlat (LIB) tgct surrfuaes cae lxigcaolsjctlrnc`s wntg il``s

Bcitfrs gfjlfstctni`y jcnatcnale nai`uel8(Ifatrf``le Rcrncm`ls)

Ifailatrctnfa fb autrnlat jf`liu`ls Ifailatrctnfa fb F= cae IF= Ifailatrctnfa fb wcstl prfeuits pG

Ifailatrctnfa fb wctlr, sc`ts, cae ftglr l`litrf`ytls Uljplrcturl Rf`ujl cae prlssurl OB]

…cae ftglrs


11/79Jcri Njgftlp Ircy, J.E. 33

Alrvfus Laefirnal

_nrl`lss_nrle

Gfrjfals

Ygfrt Enstcail @fao Enstcail

I`fslalss ]lilptfr Yplinbninty

]cpne Faslt El`cyle Faslt

Ygfrt Eurctnfa [rf`faole Eurctnfa

]cpne ]lspfasl ]lou`ctnfa

vlrsus

Alurftrcasjnttlrs Gfrjfals

Ygfrt Enstcail @fao Enstcail

Gfjlfstcsns (9)


12/79Jcri Njgftlp Ircy, J.E.3=

L]]F] YNOAC@

IFJ[C]CUF]

YLU[FNAU

+

-

IFAU]F@@LE RC]NCM@L

(YLL ALWU Y@NEL)

YLAYF]

LBBLIUF]

-ALOCUNRLBLLEMCID

Ifjpfalats fb c aloctnvlbllemcid ifatrf` systlj

Aloctnvl bllemcid8Nantnctnfa fb rlspfasls

tgct ifuatlr elvnctnfas fbifatrf``le vcrncm`lsbrfj tglnr afrjc` rcaol

Jlcsurls ifatrf` vcrncm`l

]lifoanzls elvnctnfa fb afrjc` slt pfnat vcùl

]lercwa cbtlr8 Dnmm`l HE, Gc`sly I], Gfjlfstcsns. Na8 Jlenic` [gysnf`foy -Ugl Mno [niturl 4 JiOrcw-Gn`` , =;;>4 =.

Cttljpt tf rlstfrlslt pfnat vcùl

Njpfrtcat vcrncm`l jcnatcnalewntgna c afrjc` rcaol

Lbblitfr fppfsls stnjuùs

strltig rlilptfrs, igljf-,mcrf-, fsjf-, cae tglrjf-

rlilptfrs lti.


13/79Jcri Njgftlp Ircy, J.E.39

Ifatrf``le Rcrncm`l Uypnic` Ylt [fnat Rc`ul(Crtlrnc` M`ffe Ycjp`l)

Crtlrnc` F= pcrtnc` prlssurl Crtlrnc` IF= pcrtnc` prlssurl Crtlrnc` m`ffe pGO`uifslIfrl mfey tljplrcturlYlruj Ac+Ylruj D+

Ylruj Ic=+Jlca crtlrnc` m`ffe prlssurlO`fjlru`cr bn`trctnfa rctl

3;; jj Go5; jj GopG ?.5>; jo/e@ (< jJ)>7.5»B (9?»I)35; jLq/@5.; jLq/@

5.< jLq/@>; jj Go3=; j@ /jna

Lxcjp`ls fb [gysnf`foniIfatrf``le Rcrncm`ls & Ylt [fnats

Cefptle brfj8 Dnmm`l HE, Gc`sly I], Gfjlfstcsns8 Na Jlenic` [gysnf`foy 8Ugl Mno [niturl.Alw ^frd, A^8 JiOrcw-Gn`` , =;;>4 9.



Njpfrtcat Aloctnvl BllemcidIfatrf` Yystljs

35

Jfenbnle brfj Icrrf`` ]O. L`slvnlr„s Natlorctle [gysnf`foy . Jfsmy, Nai. =;;?4 Ucm`l 3-9, [o.


15/79Jcri Njgftlp Ircy, J.E.3<

L]]F] YNOAC@

IFJ[C]CUF]

YLU[FNAU

+

Jlca Crtlrnc` M`ffe[rlssurl (JC[)

YLAYF]

LBBLIUF]

-ALOCUNRL

BLLEMCID

Lxcjp`l8 Mcrfrlilptfr ]lb`lxifatrf` fb m`ffe prlssurl

strltig rlilptfrs na Cfrtni crig cae

Icrftne snaus

A ><jj Go

IAY|Jleu``c Fm`faoctc

icrenciifatrcitn`nty,

vcsiu`cr tfal,urnacry b`une

lxirltnfa

]lilptfrs8• Cfrtni crig trcasjnts vnc vcous alrvl tf sf`ntcry aui`lus fb jleu``c (rlspfaesfa`y tf M[)• Icrftne snaus trcasjnts vnc o`fssfpgcryaolc` alrvl tf sf`ntcry aui`lus fb jleu``c (rlspfaes tf cae na M[)

Yll Mcrfrlb`lx peb

https://docs.google.com/file/d/0B-tlCbPSHvfZT1dBX3plU3huQlU/edit?usp=sharinghttps://docs.google.com/file/d/0B-tlCbPSHvfZT1dBX3plU3huQlU/edit?usp=sharinghttps://docs.google.com/file/d/0B-tlCbPSHvfZT1dBX3plU3huQlU/edit?usp=sharing



Mcrfrlilptfrs (=)

32

• Gypftlasnfa- crtlrnc` prlssurl strltig cbblrlat mcrfrlilptfr bnrnao

lbblrlat syjpctgltni bnrnao cae lbblrlat pcrcsyjpctgltni stnju`ctnfavcsfifastrnitnfa, G], ifatrcitn`nty, M[ njpfrtcat na rlspfasl tf slvlrl

gljfrrgcol

• Icrftne jcsscol - prlssurl fa icrftne crtlry strltig cbblrlatmcrfrlilptfr bnrnao G] Ica my trnle bfr Ucigyicrenc (YRU)

• Ifatrnmutls tf Iusgnao rlcitnfa (trnce fb gyplrtlasnfa, mrceyicrenc,cae rlspnrctfry elprlssnfa) natrcircanc` prlssurl ifastrnits crtlrnf`ls

ilrlmrc` nsigljnc cae rlb`lx syjpctgltni nairlcsl na plrbusnfa prlssurl( gyplrtlasnfa) strltig rlb`lx mcrfrlilptfr naeuile-mrceyicrenc



3?

Brfj gttp8//www.zuanv.alt/pgysnf`foy/mffd/igcptlr2.gtj`

Mcrfrlilptfrs (9)

http://www.zuniv.net/physiology/book/chapter6.htmlhttp://www.zuniv.net/physiology/book/chapter6.html



37

Jlca Crtlrnc` [rlssurl Ifatrf` cae Cutfafjni & Gfrjfac` Bllemcid @ffps

Dctzuao & Urlvfr. [gcrjcif`foy Lxcjnactnfa & Mfcre]lvnlw 3;tg Le. Alw ^frd8 4 JiOrcw-Gn`` , =;35.



Frocanzctnfa fb Alrvfus Yystlj

M]CNA & Y[NAC@ IF]E ILAU]C@AL]RF\Y

Y^YULJ (IAY)

[L]N[GL]C@AL]RF\Y

Y^YULJ ([AY)

CBBL]LAU

(Ylasfry)

AL]RLY

LBBL]LAU

(Jftfr)

AL]RLY

LWUL]FIL[UF]Y NAUL]FIL[UF]Y YFJCUNI C\UFAFJNI

LBBLIUF] F]OCAY

YDL@LUC@J\YI@LY

YJFFUG J\YI@L,IC]ENCI J\YI@LY

CAE O@CAEY

RF@\AUC]^

Jfafsyacptni

NARF@\AUC]^

[rl & [fst Ocao`nfani Bnmlr



=;

[lrnpglrc` Alrvfus Yystlj ([AY)

[lrnpglrc` alrvls ifatcna mftg jftfr cae slasfry alurfas

Jftfr alurfas8

sfjctni naalrvctl sdl`ltc` jusi`ls

cutfafjni naalrvctl sjfftg jusi`l, icrenci jusi`l,cae o`caes (cutfafjni jftfr alurfas)

Ylasfry alurfas crl aft sumenvnele natf sfjctni caecutfafjni m/i tglrl ns fvlr`cp na buaitnfa (naput ica mlbrfj lntglr sfjctni fr CAY)

l.o., pcna rlilptfrs ica stnju`ctl mftg sfjctni (wntgercwc` rlb`lx)cae cutfafjni rlb`lxls (nairlcsle glcrt rctl)

O n



=3

Olalrni Alurfa Cactfjy

gttp8//la.wndnplenc.fro/wndn/Alurfa

Mcsni struiturc` uant fb alrvfus systlj 111 alurfa

http://en.wikipedia.org/wiki/Neuronhttp://en.wikipedia.org/wiki/Neuronhttp://upload.wikimedia.org/wikipedia/commons/a/a9/Complete_neuron_cell_diagram_en.svghttp://upload.wikimedia.org/wikipedia/commons/a/a9/Complete_neuron_cell_diagram_en.svghttp://en.wikipedia.org/wiki/Neuron



==

Cutfafjni (Rnsilrc`) ]lb`lx ‐Buaitnfac` uant fb tgl CAY‚

Cbblrlat bnmlrs brfj plrnpglry tf IAY IAY natlorctnfa

Ifrtlx

Ugc`cjus Gypftgc`cjus

Jleu``c

Ypnac` ifre

Lbblrlat bnmlrs brfj IAY tf plrnpglry


23/79


24/79

Jcri Njgftlp Ircy, J.E.=5

Froca rlilptfrs ( na vnsius ) 1111 slasfry (cbblrlat ) alurfa 1111IAY`ctlrc` gfra il`` fb spnac` ifre 1111 jftfr (lbblrlat) alurfa ( twfalurfas8 prl & pfst ocao`nfani ) 1111 lbblitfr froca (sjfftg, icrencijusi`l fr o`cae)

Buaitnfac` \ant fb CAY 11 Rnsilrc` ]lb`lx Cri

Cbblrlat bnmlrs brfj plrnpglry tf IAYIAY natlorctnfaYpnac` ifreJleu``cGypftgc`cjusUgc`cjusIfrtlx

Lbblrlat bnmlrs brfj IAY tf plrnpglryLbblitfr rlspfasl

http://www.alexmed.edu.eg/forums/showthread.php?2116-Today-s-lecture-gt-gt-gt-BY-M..Shttp://www.alexmed.edu.eg/forums/showthread.php?2116-Today-s-lecture-gt-gt-gt-BY-M..S


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26/79


CAY Alurftrcasjnttlrs

=2

I`css

Yjc`` jf`liu`lUrcasjnttlrs

Ictligf`cjnals

Igljnic`

Ciltyìgf`nal

Efpcjnal

Afrlpnalpgrnal

Yyatglsns

Igf`nal + ciltyÌfC, vnc lazyjl

Igf`nal Cilty`trcasblrcslBrfj tgl cjnafcine tyrfsnal vnc

tgl lazyjlUyrfsnal

gyerfxy`cslna tgl

ictligf`cjnalpctgwcy

Brfj efpcjnal

na tglictligf`cjnal

pctgwcy

[fstsyacptni]lilptfrs

Aniftnani(ictnfa igcaal`)

Jusicrnani(O-prftlna ’ifup`le)

E3 (stnju`ctfryO- prftlna ’ifup`le)

E= (nagnmntfryO-prftlna ’ifup`le)

γ & ν Cerlalroni

rlilptfrs

YnoacÙlrjnactnfa

Lxtrcil`ù`crgyerf`ysns my

Ciltyìgf`nalstrcsl

]luptcdl

]luptcdl fr

mrlcdefwa vnc tgllazyjls

jfafcjnal fxnecslcae ictligf ̀’F-

jltgy`trcasblrcsl

Buaitnfas

CAYJfvljlat

ifatrfÌfoantnfa

CAYJfvljlat

ifatrfÒlalrc`cbblit

CAY

C`lrtalssOlalrc`cbblit

AM8 Lpnalpgrnal ns c ictligf`cjnal rl`lcsle upfa stnju`ctnfa fb YCAY, prfeuile na

cerlac` jleu``c. Nt ns c alurfgfrjfal, aft ca CAY alurftrcasjnttlr

Lbblrlat cutfafjni alrvls olalrc`


27/79

Jcri Njgftlp Ircy, J.E.=?

Lbblrlat cutfafjni alrvls olalrc`crrcaoljlat

Naalrvctnfa fb sjfftg jusi`l, icrencijusi`l, cae o`caes

[rlocao`nfani alurfa

[lrnpglrc` ocao`nfa - cxfelaerntni syacpsl [fstocao`nfani alurfa(s)

Lbblitfr froca(s)

[rl

Ocao`nfa

[fst

Lbblitfrfroca

n n n n b Y


28/79

Jcri Njgftlp Ircy, J.E.=7

Cactfjni Envnsnfas fb CAY

[crcsyjpctgltni ([CAY) (IA9,?,>,3;) & (Y=-Y5) [rlocao`nfani cxfas frnonactl na mrcna, cae scirc` spnac` ifre

[lrnpglrc` ocao`nc crl alcr, fbtla wntgna* tgl lbblitfr frocas

]ctnf fb pfstocao`nfani-tf-prlocao`nfani cxfas ns sjc``, rlsu`tnao naensirltl rlspfasls

Yyjpctgltni (YCAY) U3-@=/@9

[rlocao`nfani cxfas frnonactl na tgl tgfrcini cae `ujmcr ifre [lrnpglrc` ocao`nc crl enstcat brfj tgl lbblitfr frocas

]ctnf fb pfst-tf-prlocao`nfani cxfas ns `crol, rlsu`tnao na wnel`yenstrnmutle rlspfasls

Latlrni Alrvfus Yystlj (LAY) (Ensiussle na ON)

Gcs mlla elsirnmle cs c "slifae mrcna" bfr slvlrc` rlcsfas8

fplrctl cutfafjfus fb YCAY & [CAY Rlrtlmrctl stuenls sgfw wgla tgl vcous alrvl ns slvlrle, LAY

ifatnauls tf buaitnfa

* Lxilptnfas crl tgl bfur pcnrle pcrcsyjpctgltni ocao`nc fb glce cae alid

Yigljctnzle Cactfjni Ifjpcrnsfa fb

http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.pnghttp://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png


29/79

Jcri Njgftlp Ircy, J.E.=>

Yigljctnzle Cactfjni Ifjpcrnsfa fb

[CAY & YCAY (3) (i`nid tf lxpcae)

Y g tn e C t n I n

https://docs.google.com/file/d/0B-tlCbPSHvfZRGNZLWpCcUg0SG8/edit?usp=sharinghttps://docs.google.com/file/d/0B-tlCbPSHvfZRGNZLWpCcUg0SG8/edit?usp=sharinghttps://docs.google.com/file/d/0B-tlCbPSHvfZRGNZLWpCcUg0SG8/edit?usp=sharinghttps://docs.google.com/file/d/0B-tlCbPSHvfZRGNZLWpCcUg0SG8/edit?usp=sharing


30/79

Jcri Njgftlp Ircy, J.E.9;

Yigljctnzle Cactfjni Ifjpcrnsfafb [CAY & YCAY (=)

[rl

Ocao`nfa Lbblitfr

froca

[fstUgfrcini fr `ujmcrifre

[rlOcao`nfa Lbblitfr

froca

[fst

Ircanc` fr scirc` ifre[crcsyjpctgltni

Yyjpctgltni

Lbblitfrs8 icrenci jusi`l, sjfftg jj, vcsiu`cr laeftgl`nuj,

lxfirnal o`caes, cae prlsyacptni alrvl tlrjnac`s

CAY buaitnfas8 inriu`ctnfa enolstnfa rlspnrctnfa tljplrcturl swlctnao jltcmf`nsj

sfjl laefirnalo`cae slirltnfas


31/79


32/79

Jcri Njgftlp Ircy, J.E.9=

Yfjctni Alrvfus Yystlj(nai`uele bfr ifjpcrnsfa)

Lbblrlat naalrvctnfa fb sdl`ltc` jusi`l Af plrnpglrc` ocao`nc

]cpne trcasjnssnfa, ensirltl ifatrf` fb jftfr

uants

Rf`uatcryCay spnac`slojlat

Jftfr alurfa

Ytrnctle jusi`l

Jyl`nactle wn c gnog

ifaeuitnfa vl`fintyNa ifatrcst

[fstocao`nfani alurfas fb CAY crl uajyl`nactle w c `fwifaeuitnfa vl`finty

Alurfigljnic` Urcasjnssnfa na


33/79

Jcri Njgftlp Ircy, J.E.99

Alurfigljnic` Urcasjnssnfa na[lrnpglrc` Alrvfus Yystlj ([AY) Igf`nalroni alrvls

Cilty`igf`nal ns alurftrcasjnttlr

@fictnfas fb Cig [rlocao`nfani alurfas tf c`` ocao`nc

[fstocao`nfani, pcrcsyjpctgltni alurfas

‐[rlocao`nfani‚ bnmlrs tf cerlac` jleu``c

[fstocao`nfani, syjpctgltni alurfas tf swlct o`caes najfst splinls

Yfjctni jftfr alurfas

Igf`nal oni


34/79


Igf`nalroniAlurftrcasjnssnfa

[rl

Ocao`nfaLbblitfr

frocas


[rlOcao`nfa Lbblitfr

froca

[fst

Ircanc` fr scirc` ifre

[crcsyjpctgltni

Yyjpctgltni Elaftls CIg

Elaftls CIg


35/79

Jcri Njgftlp Ircy, J.E.9<

CerlalroniAlurftrcasjnssnfa

Cerlalroni alrvls Afrlpnalpgrnal ns tgl alurftrcasjnttlr

@fictnfas

[fstocao`nfani, syjpctgltni cxfas

[rl

Ocao`nfaLbblitfr

frocas


Yyjpctgltni Elaftls Afrlpnalpgrnal

Elaftls CIg


36/79


Cerlac` Jleu``c

[rlsyacptni alrvls crl igf`nalroni

Jleu``cry il``s (*Igrfjcbbna il``s) syatglsnzlcae rl`lcsl twf, rl`ctle ictligf`cjnals natfsystljni inriu`ctnfa

Lpnalpgrnal (cerlac`nal)

Afrlpnalpgrnal

Lpn cae AL stnju`ctl cerlalroni sntls

*Ugly rl`lcsl ictligf`cjnals8 ~7;% Lpnalpgrnal cae ~=;%Afrlpnalpgrnal natf systljni inriu`ctnfa bfr systljni lbblits fa ju`tnp`lfrocas (snjn`cr`y tf slirltfry alurfas fb tgl gypftgc`cjus), ica c`sf slaepcrcirnal snoac`s, glail tgly crl ic``le alurflaefirnal il``s

http://en.wikipedia.org/wiki/Paracrine_signallinghttp://en.wikipedia.org/wiki/Paracrine_signallinghttp://en.wikipedia.org/wiki/Paracrine_signalling


37/79

Jcri Njgftlp Ircy, J.E.9?

Cerlac` Jleu``c (=)

Igf`nalroni alurfa

Cerlac` jleu``c

Lpn cae AL rl`lcslenatf systljni inriu`ctnfa

Elaftls CIg

Igrfjcbbna il``s crl alurflaefirnal il``s bfuae na tgljleu``c fb tgl cerlac` o`caes

Ugly crl na i`fsl prfxnjnty tf prl-syacptni syjpctgltniocao`nc fb syjpctgltni alrvfus systlj, wntg wgnig tglyifjjuanictl

struiturc``y snjn`cr tf pfst-syacptni syjpctgltni alurfas

Y b C tn b YCAY & [CAY (3)


38/79


Yujjcry fb Citnfas fb YCAY & [CAY (3)

Y^JCUGLUNIBrnogt-Bnogt-fr-B`nogt wnel`y enstrnmutle rlspfasls

[C]CY^J[CUGLUNI]lst-]l`cx-]lstfrctnfa ensirltl rlspfasls

nairlcsl na glcrt rctl elirlcsl na glcrt rctl

elirlcsl na ocstrni jftn`nty nairlcsl na ocstrni jftn`nty

elirlcsl slirltnfa fb sc`nvcry

cae enolstnvl o`caes

nairlcsl na slirltnfa fb sc`nvcry

cae enolstnvl o`caes en`ctnfa fb pupn`s ifastrnitnfa fb pupn`s

lhciu`ctnfa plan`l lrlitnfa

vcsfifastrnitnfa ifatrcitnfa fb sjfftg jusi`l na

wc``s fb m`ceelr en`ctnfa fb mrfaignf`ls

nairlcsle slirltnfa fb swlcto`caes

Fb aftl8 Icaafa„s ljlrolaiy rlcitnfa8 Ca njjlenctl syjpctgltni rlspfasl tf `nbl-tgrlctlanao sntuctnfas wntg mftg YCAY cae[CAY fvlrcitnvnty. Ugl [CAY pglafjlafanai`uels vcoc` icrenci crrlst wntg navf`uatcry

elblictnfa cae urnactnfa

Y b C tn b YCAY e [CAY (=)


39/79

Jcri Njgftlp Ircy, J.E.9>

Yujjcry fb Citnfas fb YCAY cae [CAY (=)

Ufy L, ]fslabl`e O, @ffsl E, Mrnsifl E. ICYL 3, Cutfafjni YyjpctgltniAlrvfus Yystlj, Na Icsl Bn`ls8 [gcrjcif`foy = le. JiOrcw-Gn`` =;;74 32.

(i`nid tf lxpcae)

Yyjpctgltni]lspfasls glcrt rctl nairlcsls m`ffe prlssurl

nairlcsls m`ffe ns sguatle

brfj sdna & vnsilrctf sdl`ltc` jusi`ls

m`ffe o`uifslnairlcsl

mrfaignf`ls en`ctl pupn`s en`ctl

[crcsyjpctgltni]lspfasls s`fws glcrt rctl prftlits rltnac brfj

lxilssnvl `nogt (alcr `fwlrs m`ffe prlssurl

ljptnls tgl mfwl`cae m`ceelr

nairlcslsocstrfnatlstnac`jftn`nty

prfjftls cmsfrptnfafb autrnlats

https://docs.google.com/file/d/0B-tlCbPSHvfZVlM1alF3aDE1UXc/edit?usp=sharinghttps://docs.google.com/file/d/0B-tlCbPSHvfZVlM1alF3aDE1UXc/edit?usp=sharinghttps://docs.google.com/file/d/0B-tlCbPSHvfZVlM1alF3aDE1UXc/edit?usp=sharinghttps://docs.google.com/file/d/0B-tlCbPSHvfZVlM1alF3aDE1UXc/edit?usp=sharinghttps://docs.google.com/file/d/0B-tlCbPSHvfZVlM1alF3aDE1UXc/edit?usp=sharing


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CIg Yyatglsns, ]l`lcsl, cae Bctl (3)

Yyatglsnzle brfj igf`nal cae cilty`-IfC

]l`lcsle na rlspfasl tf alurfac` elpf`crnzctnfa(citnfa pftlatnc`)

Ic`inuj latlrs tgl alrvl il``

Urcasjnttlr vlsni`ls busl wntg il`` jljmrcal

CIg rl`lcsle my lxfiytfsns

Nacitnvctle my cilty`igf`nalstlrcsl (CIgL)

CIg Y tg n ] ` e B t (=)


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CIg Yyatglsns, ]l`lcsl, cae Bctl (=)

53

IGU - Igf`nal trcaspfrtlr IgCU - Igf`nal cilty` trcasblrcsl RCU - Rlsni`l-cssfinctle

trcaspfrtlr RCJ[s - Rlsni`l-cssfinctle

jljmrcail prftlnas

YAC[„s - Yyacptfsfjl-cssfinctle prftlnas


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Igf`nalroni Alurfa [gcrjcif`foy

5=Brfj @l U., Mgusgca R. Bnrst Cne =;3?. Alw f̂rd, A^8 J-G. =;3?.


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AL Y tg n ] ` e B t (=)


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AL Yyatglsns, ]l`lcsl, cae Bctl (=)

55

RJCU-Rlsniu`cr Jfafcjnaltrcaspfrtlr

e n g `


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Cerlalroni Alurfa [gcrjcif`foy

5<Brfj @l U., Mgusgca R. Bnrst Cne =;3?. Alw f̂rd, A^8 J-G. =;3?.

]lilptf s*


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]lilptfrs* Yplinc`nzle prftlnas tgct crl mnaenao sntls bfr

alurftrcasjnttlrs cae gfrjfals

[fstsyacptni il`` jljmrcals(alurftrcasjnttlrs)

Il`` aui`lus (stlrfne gfrjfals)

@nadle tf fal fb jcay snoac` trcaseuitnfa jligcansjs

‐]lilptfr‚ (Ciifrenao tf ]cao & Ec`l [gcrjcif`foy)8 C tcrolt fr mnaenao prftlna bfr c sjc`` jf`liu`l (`nocae),wgnig cits cs ca cofanst fr catcofanst.]cao G[, Jcurlla J. Ec`l JJ, ]nttlr HJ , B`fwlr H Glaelrsfa O . ]cao & Ec`l's[gcrjcif`foy, ?tg le. Igurign`` @nvnaostfal4 =;33.

* ‐aft tf ml ifabusl wntg ftglr eruo tcrolts suig cs lazyjls lti .‚

@nocae ]lilptfr Natlrcitnfas

http://en.wikipedia.org/wiki/Signal_transductionhttp://en.wikipedia.org/wiki/Signal_transductionhttp://en.wikipedia.org/wiki/Signal_transductionhttp://en.wikipedia.org/wiki/Signal_transduction


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@nocae-]lilptfr Natlrcitnfas Ifjp`ljlatcry ifabfrjctnfas na 9 enjlasnfas

Ynjn`cr tf lazyjl-sumstrctl natlrcitnfas

[gysnf`foni natlrcitnfas crl wlcd cttrcitnfas

G-mfaenao, vca elr _cc`„s bfrils

Eruo jligcansjs

Cofansts - mnae cae citnvctl rlilptfrs

Catcofansts - mnae mut EF AFU citnvctl rlilptfrs

"]lilptfr" ciifrenao tf N\[GC] 8 (Natlractnfac` \anfa fb Mcsni cae I`nanic`[gcrjcif`foy)

‐C il``u`cr jcirfjf`liu`l, fr ca cssljm`y fb jcirfjf`liu`ls, tgct nsifailrale enrlit`y cae splinbnic``y na igljnic` snoac`nao mltwlla cae wntgnail``s. Ifjmnactnfa fb c gfrjfal, alurftrcasjnttlr, eruo, fr natrcil``u`crjlsslaolr wntg nts rlilptfr(s) nantnctls c igcaol na il`` buaitnfa.‚

Yll8 Mcsni ]lilptfr [gcrjcif`foy/ [EB

Ytlps na Ynoac` Urcaseuitnfa [rfilss

http://www.iuphar-db.org/https://docs.google.com/file/d/0B-tlCbPSHvfZZVVFMzlnWXphdkU/edit?usp=sharinghttps://docs.google.com/file/d/0B-tlCbPSHvfZZVVFMzlnWXphdkU/edit?usp=sharinghttp://www.iuphar-db.org/


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Ytlps na Ynoac` Urcaseuitnfa [rfilssYll8 O-prftlna Ynoac` Urcaseuitnfa (vnelf canjctnfas)

57

Uglrl crl bfur olalrc` i`cssls fb snoac` trcaseuinao rlilptfrs8 O-prftlnas crl fal cae crl rlblrrle tf cs slrplatnal rlilptfrs

Mnaenao fb tgl alurftrcasjnttlr,gfrjfal fr eruo tf rlilptfr1 snoac`naofb O-prftlna1 lazyjl citnvctnfa1prfeuitnfa fb c slifae-jlsslaolr1prftlna dnacsl citnvctnfa 1pgfspgfry`ctnfa fb splinbni prftlnas(lbblit)1 tlrjnactnfa

O[I] struiturl & buaitnfa (snjp`nbnle)

http://www.youtube.com/user/llkeeley?feature=mheelhttp://themedicalbiochemistrypage.org/signal-transduction.htmlhttp://themedicalbiochemistrypage.org/signal-transduction.htmlhttp://www.youtube.com/user/llkeeley?feature=mheel


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Jcri Njgftlp Ircy, J.E.5>

Alurfgfrjfal lpnalpgrnal cae nts rlilptfr (pnad) ns usle na tns lxcjp`l8 Citnvctle rlilptfr rl`lcsls tgl Os c`pgc prftlna (tca) brfj tgl mltc cae ocjjcsumuants (m`ul cae orlla) na tgl gltlrftrnjlrni O-prftlna ifjp`lx. Uglcitnvctle Os c`pgc prftlna na tura citnvctls celay`y` iyi`csl (purp`l) tgctifavlrts CU[ natf tgl slifae jlsslaolr iCJ[

Jligcansj fb iCJ[ elplaelat snoac`nao

O[I] struiturl & buaitnfa (snjp`nbnle)

O-[rftlna Ifup`le ]lilptfr

Mnaenao fb AU, gfrjfal fr eruotf rlilptfr1 snoac`nao fb O-prftlna1 lazyjl citnvctnfa1prfeuitnfa fb c slifae-jlsslaolr1 prftlna dnacsl

citnvctnfa 1pgfspgfry`ctnfa fbsplinbni prftlnas (lbblit)1tlrjnactnfa

O [ n J [ g

http://en.wikipedia.org/wiki/Epinephrinehttp://en.wikipedia.org/wiki/Adrenergic_receptorhttp://en.wikipedia.org/wiki/Adrenergic_receptorhttp://en.wikipedia.org/wiki/Epinephrinehttp://en.wikipedia.org/wiki/Signal_transductionhttp://en.wikipedia.org/wiki/Signal_transduction


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Yigljctni fb Igf`nalroni ]lilptfr


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57/79


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Yigljctni rlprlslatctnfa fb Cerlalroni]lilptfr @fictnfas

Yyjpctgltni

[rl

Ocao`nfa

pcrcvlrtlmrc` ,prlvlrtlmrc` fr `ctlrc`

Lbblitfrfrocas


C`pgc fr Mltccerlalroni rlilptfrs

Buaitnfac` Ynoanbnicail fb CAY (3)

http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.pnghttp://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.pnghttp://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png


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Froca systlj natlorctnfa

[crcsyjpctgltni

Ensirltl naalrvctnfa Lalroy ifaslrvctnfa

Yyjpctgltni Gnog`y enstrnmutle naalrvctnfa, o`fmc` rlspfasls

Lalroy lxplaenturl

Bnogt fr b`nogt rlspfasls

Buaitnfac` Ynoanbnicail fb CAY (3)

‐Froca systlj natlorctnfa & Euc` naalrvctnfa‚


61/79


Buaitnfac` Ynoanbnicail fb CAY (=)

Euc` naalrvctnfa Froca rlspfasls jfelrctle my mftg

pcrcsyjpctgltni cae syjpctgltni nab`ulails

[crcsyjpctgltni efjnacat ct rlst [rlefjnactl tfal

Mc`cail fb fppfsnao alurf`foni nab`ulailseltlrjnals pgysnf`foni rlspfasls

` g e n


62/79

Jcri Njgftlp Ircy, J.E.2=

C`pgc-3 Cerlalroni ]lilptfr

Rcsiu`cr sjfftg jusi`l ifatrcitnfa Crtlrnf`ls, vlnas

Nairlcsle crtlrnc` rlsnstcail Elirlcsle vlafus icpcintcail

Cofansts suppfrt systljni m`ffe prlssurl Nairlcsle rlsnstcail ]lenstrnmutnfa fb m`ffe tfwcre glcrt,

nairlcsle icrenci futput

Catcofansts elirlcsl m`ffe prlssurl Nrns

[upn``cry en`ctnfa (jyerncsns)


63/79


C`pgc-= Cerlalroni ]lilptfr

pfstsyacptni γ=-cerlafilptfrs (`fictle na mèvlssl`s) icusl ifastrnitnfa

Jfeu`ctnfa fb AL rl`lcsl

[rlsyacptni rlilptfrs fa cxfa tlrjnaus

Ypnac` c`pgc-= rlilptfrs jlenctl cacòlsnc

Cofansts usle i`nanic``y cs lpneurc` cae spnac`cacòlsnis

Ylectnfa


64/79


Mltc-3 Cerlalroni ]lilptfr

Uf jyficrenuj (rlac`-rlana cae bct il`` c`sf) Cofansts

Nairlcsl G], ifatrcitn`nty, cae njpu`slifaeuitnfa splle

Jcy ml crrgytgjfolani

Catcofansts

Elirlcsl G], ifatrcitn`nty, cae njpu`sl

ifaeuitnfa splle

\sle i`nanic``y cs catncrrgytgjnis


65/79

Jcri Njgftlp Ircy, J.E.2<

Mltc-= Cerlalroni ]lilptfr

Rcsiu`cr sjfftg jusi`l na sdl`ltc` jusi`l Cofansts lvfdl citnvl vcsfen`ctnfa, nairlcsle

m`ffe b`fw

Mrfaignc` sjfftg jusi`l Cofansts lvfdl mrfaigfen`ctnfa, elirlcsle

cnrwcy rlsnstcail


66/79

Lbblit fb CAY fa Froca Yystljs (3)


67/79


]lilptfr Buaitnfa Enstrnmutnfa

γ3 Ifastrnitnfa fb sjfftg

jusi`ls

M`ffe vlssl`s cae pn`flrlitfrs na sdna

(vcsfifastrnitnfa cae offsl mujps)

Ypgnaitlrs (m`ceelr, ocstrfnatlstnac` TONZ)

\tlrus cae prfstctl (ifatrcitnfa)

Lyl (ifatrcitnfa fb tgl rcenc` jusi`l :

pupn``cry en`ctnfa/jyerncsns)

γ= Nagnmntnfa fb syjpctgltni

cutfafjni ocao`nc

(elirlcsls YCAY)

[rlsyacptni ocao`nfani alurfas

ON trcit (`lss njpfrtcat pgcrjcif`fonic``y)


Yyjpctgltni (AL)

Lbblit fb CAY fa Froca Yystljs (=)


68/79


Lbblit fb CAY fa Froca Yystljs (=)Yyjpctgltni (AL)

]lilptfr Buaitnfa Enstrnmutnfa|Froca

ν3 Nairlcsl icrenci plrbfrjcail

cae `nmlrctnfa fb lalroy

Glcrt-jfst njpfrtcat (nairlcsle

igrfaftrfpy, naftrfpy, erfjftrfpy)

Bct il``s (rl`lcsl bct bfr lalroy vnc `npf`ysns)

Dnealy (rl`lcsl rlana tf ifaslrvl wctlr)

ν= ]l`cxctnfa fb sjfftg jusi`ls

cae `nmlrctnfa fb lalroy

@uaos (mrfaigfen`ctnfa)

M`ffe vlssl`s na jusi`ls (vcsfen`ctnfa)

\tlrus (utlrnal rl`cxctnfa)

ON (natlstnac` rl`cxctnfa)

M`ceelr (m`ceelr rl`cxctnfa)

@nvlr (tf `nmlrctl o`uifsl vnc

o`yifolaf`ysns)



69/79


Lbblit fb CAY fa Froca Yystljs (9)[crcsyjpctgltni (Cig)

]lilptfr Buaitnfa Enstrnmutnfa|Froca

A (Aniftnani) "Alrvl tf alrvl" &

"alrvl tf jusi`l"

ifjjuanictnfa

YCAY & [CAY ocao`nc

Alurfjusiu`cr huaitnfa (AJH)

J (Jusicrnani) Uf fppfsl jfst

syjpctgltni citnfas

ct tgl `lvl` fb tglfrocas

@uao (mrfaigfifastrnitnfa)

Glcrt (s`fwlr rctl, elirlcsle ifaeuitnfa, elirlcsle

ifatrcitn`nty)

Ypgnaitlrs fb ON cae m`ceelr (rl`cx)

M`ceelr (ifastrnitnfa)

ON (natlstnac` ifatrcitnfa)

Lyl (ifatrcitnfa fb tgl inriu`cr jusi`l : pupn``cry

ifastrnitnfa fr jnfsns)

Lyl (ifatrcitnfa fb tgl in`ncry jusi`l : bfius bfr alcr

vnsnfa)


70/79

Jcri Njgftlp Ircy, J.E.?;

Aniftnani CIg rlilptfrs crl `nocae-octle Ac+/D+igcaal`sUwf sumtypls8 AA (bfuae na cutfafjni ocao`nc, cerlac`jleu``c) cae AJ (bfuae na AJH fb sdl`ltc` jusi`l)

Jusicrnani CIg rlilptfrs crl O-prftlna ’ifup`le rlilptfrs

tgct usuc``y cit tgrfuog =ae jlsslaolrsBnvl sumtypls8 J3 ’< bfuae na glcrt, sjfftg jusi`l, mrcna,lxfirnal o`caes, cae fa swlct o`caes (igf`nalroni syjpctgltni)

Cilty`igf`nal rlilptfrs

Lxilptnfa


71/79

Jcri Njgftlp Ircy, J.E.?3

LxilptnfaYyjpctgltni naalrvctnfa fb cerlac` jleu``c ns enrlit brfjspnac` ifre cae usls CIg cs alurftrcasjnttlr

Cerlac` o`cae buaitnfas cs c splinc` bfrj fb ocao`nfa tgct slirltlsLpn & AL na c 5 tf 3 rctnf enrlit`y natf tgl m`ffestrlcj

Yyjpctgltni pfstocao`nfani alurfas tgct naalrvctl rlac` vcsiu`crsjfftg jusi`l rl`lcsl efpcjnal rctglr tgca afrlpnalpgrnal

Njpfrtcat aftl8

Uglrl ns af pcrcsyjpctgltni bnmlr naalrvctnfa fb m`ffe vlssl`s,mut m`e vlssl`s ef gcvl jusicrnani rlilptfrs

Bfr lxcjp`l , na ifrfacry crtlrnls stnju`ctnfa J9 rlilptfrs icuslrl`lcsl fb AF wgnig rlsu`t na vcsfen`ctnfa

Ywlct o`caes crl naalrvctle my syjpctgltni alrvls, mut pcrcefxnic``yusl jCIg]

Ylxuc` crfusc` ns pcrcsyjpctgltni, mut frocsj ns syjpctgltni

Cutfafjni cae Yfjctni AY


72/79

Jcri Njgftlp Ircy, J.E.?=

Cutfafjni cae Yfjctni AY[gcrjcif`foy Ulrjnaf`foy

Jcay eruos lvfdl lbblits my natlrcitnao wntg rlilptfrs

Cbbnanty

Lbbniciy fr (syafayj) Natrnasni citnvnty

Cofansts

Jnjni pgysnf`foni citnvctnfa

Gcvl mftg gnog cbbnanty cae lbbniciy

Catcofansts

M`fid citnfas fb alurftrcasjnttlrs fr cofansts

Gcvl gnog cbbnanty, mut af lbbniciy

Fbtla usle cs pgcrjcif`foni rlvlrsc` colats

Ynoac`nao Jligcansjs cae [gcrjcif`foy fb


73/79


Cerlalroni-]lilptfr Uypl

[gysnf`foni Cofanst

Ynoac`naoJligcansj

[gcrjcif`foni Cofanst

[gcrjcif`foni Catcofanst

γ3 Afrlpn ≬ Lpn N[9/ECO/Ic=+ [glay`lpgrnal [rczfsna

γ= Afrlpn ≬ Lpn ↙ TiCJ[Z I`fanenal,

jltgy`efpc

^fgnjmnal

ν3 Lpn 1 Afrlpn ↓ TiCJ[Z Efmutcjnal (ν31 ν=),

nsfprftlrlaf` (ν3: ν=)

Jltfprf`f`

ν= Lpn 1 Afrlpn ↓ TiCJ[Z C`mutlrf`,nsfprftlrlaf`

(ν3 : ν=)

[rfprcaf`f`(afasl`litnvl ν3

cae ν=)

Y o c o li c s s c e c cif foy f CAY ]lilptfr Yumtypls- YCAY

Ynoac`nao Jligcansjs cae [gcrjcif`foy fb


74/79


Igf`nalroni-]lilptfr

Uypl

[gysnf`foni Cofanst

Ynoac`naoJligcansj

[gcrjcif`foni Cofanst

[gcrjcif`foni Catcofanst

A3:AJ Ciltyìgf`nal Nfaftrfpnirlilptfr

Aniftnal E-Uumfiurcrnal

A=:AO Ciltyìgf`nal Nfaftrfpnirlilptfr

Aniftnal Glxcjltgfanuj,jlicjy`cjnal

J3 ’< Ciltyìgf`nal Rcrnfus Mltgcaligf`,jltgcigf`nal,pn`ficrpnal

Ctrfpnal,mlaztrfpnal,nprctrfpnuj

o o oy CAY ]lilptfr Yumtypls- [CAY

[AY sujjcry sigljctni


75/79

Jcri Njgftlp Ircy, J.E.?<

@l U., Mgusgca R. Bnrst Cne =;3?. Alw ̂ frd, A^8 J-G. =;3?.

Yujjcry8 Ucdl Gfjl [fnats (3)


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Yujjcry8 Ucdl Gfjl [fnats (3)

CAY buaitnfas navf`vl c vcrnlty fb lbblitfr tnssuls, nai`uenao8

icrenci jusi`l, sjfftg jj, vcsiu`cr laeftgl`nuj, lxfirnalo`caes, cae prlsyacptni alrvl tlrjnac`s

Uf uaelrstcae CAY buaitnfa , cae my lxtlasnfa gfw tfpgcrjcif`fonic``y jcanpu`ctl CAY, yfu wn`` alle uaelrstcae gfwtwf envnsnfas fb CAY iflxnst cae buaitnfa, gfw lcig sumenvnsnfalxlrts nts lbblits, cae bnac``y wgct pgysnf`foni cae pgcrjcif`fonijligcansjs lxnst tf nairlcsl fr elirlcsl lcig sumenvnsnfa„s citnvnty

Yujjcry8 Ucdl Gfjl [fnats (=)


77/79

Jcri Njgftlp Ircy, J.E. ??

My usnao eruos tgct jnjni fr m`fid citnfas fb igljnic` trcasjnttlrs cae /

fr tglnr rlilptfr jligcansjs, wl ica sl`litnvl`y jfenby cutfafjnibuaitnfas

Cutfafjni eruos crl uslbu` na jcay i`nanic` ifaentnfas, gfwlvlr c `crolaujmlr fb eruos usle bfr ftglr i`nanic` purpfsls gcvl uawcatle lbblits

fa cutfafjni buaitnfa4 cae mlicusl fb umnquntfus acturl fb CAY,cutfafjni eruos crl brlqulat`y afa-sl`litnvl cae tgus ica ml cssfi. wsnel lbblits

Mfttfj `nal| jljfrnzctnfa fb rlilptfrs, tglnr enstrnmutnfa,

snoac` trcaseuitnfa jligcansjs cae tglnr lbblits ns jcaectfrycae wn`` lacm`l yfu tf ciiurctl`y prlenit lbblits, snel lbblits,pftlatnc` tfxnintnls cae natlrcitnfas fb CAY eruos

Yujjcry8 Ucdl Gfjl [fnats (=)


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Burtglr stuey8


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Burtglr stuey8Ifjpcanfa aftls CAY Yujjcry Aftls

Crtni`ls@curnl Dl``y JiIfrry. [gysnf`foy fb tgl Cutfafjni Alrvfus Yystlj Cj H [gcrj Leui. =;;? Cuoust 3)8?=> >89>>-593

[fwlr[fnat [rlslatctnfa8

Ircy JN. _c`tlr Icaafa, Gfjlfstcsns cae tgl [gysnf`fonic` ]lspfasl tf Ytrlss. C _lm Natlrcitnvl [fwlr[fnat [rlslatctnfa , =;35
https://drive.google.com/file/d/0B-tlCbPSHvfZS1ZZbWVqbjJNUlE/view?usp=sharinghttp://annals.org/article.aspx?articleid=715764http://annals.org/article.aspx?articleid=715764http://annals.org/article.aspx?articleid=715764http://annals.org/article.aspx?articleid=715764http://annals.org/article.aspx?articleid=715764https://docs.google.com/file/d/0B-tlCbPSHvfZdTlzNnY4bzFtb2s/edit?usp=sharinghttps://drive.google.com/file/d/0B-tlCbPSHvfZMmdkdFFRWGdRR1E/view?usp=sharinghttps://drive.google.com/file/d/0B-tlCbPSHvfZMmdkdFFRWGdRR1E/view?usp=sharinghttps://docs.google.com/file/d/0B-tlCbPSHvfZdTlzNnY4bzFtb2s/edit?usp=sharinghttp://annals.org/article.aspx?articleid=715764https://drive.google.com/file/d/0B-tlCbPSHvfZS1ZZbWVqbjJNUlE/view?usp=sharing

ans pharmacology -introduction | review of the autonomic nervous system

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