introduction to autonomic pharmacology: part vi interaction of drugs with the autonomic
DESCRIPTION
INTRODUCTION TO AUTONOMIC PHARMACOLOGY: Part VI Interaction of drugs with the autonomic nervous system. SYMPATHOMIMETICS: Drugs that facilitate or mimic some or all of the actions of the sympathetic nervous system. Indirect Acting. Direct Acting. Drugs that facilitate NE release. - PowerPoint PPT PresentationTRANSCRIPT
INTRODUCTION TO AUTONOMIC PHARMACOLOGY: Part VI
Interaction of drugs with the autonomic nervous system
SYMPATHOMIMETICS: Drugs that facilitate or mimic some or all of the actions of
the sympathetic nervous system.
Direct Acting
Indirect Acting
Drugs that facilitate NE release
Drugs that block NE uptake-adrenergic agonists
-adrenergic agonists
Ganglionic blocking
drugs
Centrally acting sympatholytics
NE depleting drugs
Drugs that inhibit NE synthesis
Adrenergicneuronal
blocking drugs
-adrenergicantagonists
-adrenergic antagonists
SYMPATHOLYTICS: Drugs that reduce or inhibit some or all of the actions of the
sympathetic nervous system.
PARASYMPATHOMIMETICS (CHOLINOMIMETICS): Drugs that
facilitate or mimic some or all of the actions of the parasympathetic nervous system.
Muscarinic receptor agonists
Anticholinesterases
PARASYMPATHOLYTICS (ANTICHOLINERGICS): Drugs that reduce
or inhibit some or all of the actions of the parasympathetic nervous system.
Muscarinic receptor
antagonistsGanglionic blocking
drugs
Predicting Responses of Drugs that
Interact with the Autonomic
Nervous System
Baroreceptor Reflex
Baroreceptor Reflex
BP(mmHg)
SNA(Units)
PSNA(Units)
HR(bpm)
Time (minutes)
Phenylephrine Histamine
Predicting Responses
1 & 2
1, 2, 1 & 2
1, 1 & 2
ACH (2 g)
ACH (5 mg)
ACH (50 g)
ACH (50 g)
ACH (5 mg)
Heart Rate Blood Pressure
(Atropine: Muscarinic Receptor Antagonist)
(Hexamethonium: Neuronal Nicotinic Receptor Antagonist)