factores que modifican la toxicidad

8/17/2019 Factores Que Modifican La Toxicidad

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EDAD GERIÁTRICA

Deterioro de la función hepática y renal.Incremento del pH del jugo gástrico.

Disminución de la motilidad intestinaly atrofia de la mucosa.

Menor proporción de albúmina plasmáticay otras proteínas transportadoras.

Aumento del tejido adiposo y disminuciónde la masa muscular y el agua total.


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Insuficiencia hepática(por reducción de lacapacidad metabolizante general)

Aumentan la vida media del tóxicoal prolongar el tiempo de

permanencia en el organismo

Insuficiencia renal

Insuficiencia hepática+

ESTADO DE SALUD


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factores que modifican la toxicidad

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