exposición química bioinorgánica final.pptx

7/25/2019 Exposicin Qumica Bioinorgnica final.pptx

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METALOFRMACOS CONTRA LAENFERMEDAD DEL ALZHEIMER (EA) Y

COMPLEJOS Y COMPUESTOSORGANOMETLICOS DE RUTENIO CON

ACTIVIDAD ANTITUMORAL

GODNEZ LOYOLA YOKARI

PEDRO HERNNDEZ LUIS DANIEL DRA. LENA RUIZ

19 DE NOVIEMBRE DEL 2014

UNIVERSIDAD NACIONAL AUTNOMA DE MXICO

FACULTAD DE QUIMICAQUMICA BIOINORGNICA


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Fue descr!" #$r#r%er" &e' #$r e#su"!r" *+eur$#"!,$-$ "e%.+A$s A'/e%er e+0123 e+ e 444VIIC$+-res$ dePsu"!r"s desur$es!e de Ae%"+"5

C$+sder"d$ e #"drede " +eur$#"!$$-6"5

7u6%c" 8$+$r-.+c" METALOFRMACOS CONTRA LA EA Y COMPLEJOS Y COMPUESTOS ORGANOMETLICOS DERUTENIO CON ACTIVIDAD ANTITUMORAL


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Enfe!e"#" ne$%"e&ene#'()#* +%&e,()# e (e)e,(-e.

P/"("# +%&e,()# e (e)e,(-e "e # !e!%(#* # %(en'#(n e#3%n#!(en'% e, "e(* $n# "e&ene#(n ne$%n# ,ee'()#.



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P#(en'e, %n EA +e,en'#n6

Un# "e&ene#(n ne$%n# n$%)#$%#.

Un (ne!en'% "e %, +%"$'%, "e "#7%%8("#'()%.

Un# #$!$#(n "e #&e"%, +%'e(%,6O)(%, ne$%-(#e, :ON;6


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E,'#"(% "e!en(# !%"e#"#6

E +#(en'e +e(,# #$"# +## en'en"e en% e%n%en en'%n%, '(+% #,#,* =#-('#

EA en f#,e "e "e!en(# )e6

L%, +#(en'e, +e(,#n #$"# +## '%"

-,(#, "e # )("# "(#(#. In((#n $n# (nA+en#, %!+en"en e en&$#e %!+e%

L# e'#+# 'e!(n# "e # EA e, $n e,'#"'%'# "e !e"(% e8'en%* "%, )#(#-(&("e3 &ene#(3#"#. L%, +#(en'e, f#"e-(('#!(en'% +%&e,()% %!+(#(



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E +/+'("% ? #!(%("e '(ene 4042 #!(n%("%, "e e8'en,(n.

H(+'e,(, "e # #,#"# "e#!(%("eJ* $e +%+%ne #

&ene#(n # f%!#(n "e%(&!e%, ne$%'8(%, "e+/+'("%?A.



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P%'en# Pe$,%# "e A!(%("e

L# +%'en# +e#!(%("e @PPA &$%+%'en# '#n,!e!-#n# +e,en'# %n (,%f%!#,.

L#, (,%f%!#, "e0* ,e e8+e,#n$-($#* !(en'#, F9C* ,e e,+e#!en'e ene)(%,% en'# @S



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U+ "u%e+!$ e+ "c$+ce+!r"c,+ de A9"&$rec6" "9$r%"c,+ de "#r$!e6+" T"u *:c$+secue+!e%e+!e:" 9$r%"c,+ de$&$s

+eur$;


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E $+ c$#!d$ A:d$%+$ (PPA3B00)5



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PPA +e,en'# #+#("#" e"$'%#,%-e e >$6


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%nen'#(n +e+'"(#4C0.

Re(en'e!en'e ,e =# "e,('% $e e +/+'("% ?A $ne %-e %n $n# #'# #n("#" +e,en'# en,$ e,'$'$# $n ,('(% "e %%"(n#(n%%+e#'()# #%,'/(% +% e,'e !e'#.



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L%, #&e"%, "e +/+'("% ? A '(enen $nefe'% ne$%'8(% en e #n&% "e%nen'#(n !(%!%#.

E ? A +e,en'# $n# e,'$'$# $!(# $ef#(('# # f%!#(n "e ERO. En e,'%,+%e,%, (n'e)en"#n !e'#e, %!% =(e%

%-e.P% % '#n'% %, !e'#e, 'en"#n $n efe'% "$#6

P%!%)(en"% # #&e(n "e +/+'("% ? A

P%'en(#n"% ,$ #(n '8(# )# #&ene#(n "e ERO



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Z(n

E (%n (n (n"$e #

+e(+('#(n "e ? A +##f%!# +#'e "e #, +##, "e#!(%("e.

#!-(/n e, #+#3 "e ,$+(!(+#(#!en'e # f%!#(n "eH2O2f%!#"% +% e ? A.

Se =# ,$&e("% $e #, PS+%"#n %e,+%n"e # $n

,(,'e!# "e "efen,# e$#*"%n"e e (%n (n +e(+('# e+/+'("% ? A (n=(-(en"% ,$#'()("#" %8("#,#.



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P$r $!r" #"r!e e=s!e s$


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C$%#ues!$s c$+ #$s


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Porcentaje de inhibicin ante la agregacin de A



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Generacin de radicales OH* a partir de la reacredox Cu/Ascorbato.



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C$%#e$s *c$%#ues!$s$r-"+$%e!.c

$s deRu(II)KRu(III)

c$%$

#$!e+c"es"+!!u%$r"es



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Cs#"!+$: #r%er 9.r%"c$u!'"d$ c$%$ "+!!u%$r" ue

c$+!e+6" u+ %e!" e+ sues!ruc!ur"5

S+ e%!% ,e (n((% #-,$e"# "e n$e)%,

#n'('$!%#e,



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E c$%#e$ "re+$ Ru(II) %$+$de+!"d$ :de !#$ (3B"re+$)Ru(II)(e+)CPF3

c$+s!!u*e u+ -ru#$ de "+!!u%$r"esc$+ u+ %ec"+s%$ de "cc,+ d9ere+!e "

de $s c$%#e$s de Ru(III)5 Ru(3B#Bc*%e+)C(PTA

RAPTABC



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Mec"+s%$ de "cc,+:1;

:1;. >HAERQE* S%$!#* KUND* S$-=#"(+* BHAA>HARYYA* A(n"DYSON* P#$ Q.Journal of Biological Inorganic Chemistry. @200. 156



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S$+e8("% "(,!$'#,#

U-($('n#

>


:2;


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: ;

:2;. U* B(n* ONG* M(=ee S.* GROSSEL* M(=#e* ADHIREKSAN* Zen('#* HARINGER*>=(,'(#n G.* DYSON* P#$ Q.* DAVEY* >$' A. Chemistry European Journal. 2011. 1. 5CF25CFF.



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Es u+ #reB9.r%"c$ "+!%e!.s!c$ ue se e+cue+!r" e+9"se II de #rue


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Mec"+s%$ de "cc,+De


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(!r"+sB!e!r"c$r$


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Mec"+s%

:C;. VAKASH* S(n&=* GAQENDRA* K.A3#"* AMARENDAR* Re""*M.*SHIVANI*B##n\#. European Journal of Pharmacology. 736 (20!"# 77$%&.


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L%, #"(#e, (-e,]


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O!r$ #$s


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M.s #$s


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Re9ere+c"s

VAASH: S+-/: GAJENDRA: 5A'"d: AMARENDAR: Redd*:M5:SHIVANI: 8"r"+Q"5 European Journal of Pharmacology. 736 (201 VAASH: S+-/: GAJENDRA: 5A'"d: AMARENDAR: Redd*:M5: PAPITA: M"+d": RAAGUHVIR: T$%"r5 !E"# $e%%er&. 88(2014), 1 MAZURI: O-": URPIESA: "!"r'*+": LEINSI: r'*s'!$9: STOCHEL: Gr"*+": 8RINDELL: M"-$r'"!"5Jounal of 'norgan"ochem&%ry5 003 (20): 00B05

APITZA: Sus"++e: JAUPEC: Mc/"e A5: UHL: M"r": EPPLER: 8er+/"rd 5: MARIAN: 8r-!!e5ancer $e%%er&. 226 (200), 11

8RA8EC: V!$r: NOVOV: O-"5 *rug +e&&%ance pa%e&5 1 (223)5 000W05 CASINI: A+-e": GA88IANI: C/"r": MICHELUCCI: Ee+": PIERACCINI: Guse##e: MONETI: G$r"+$: DYSON: P"u J:: MESSORI: Lu"ologcal 'norganc hem&%ry5 (221) 0X?30W25

RATAAPHAN: Ads$r+: TEM8OOTA: P$r+&c/": DYSON: P"u J5 hem&%ry an "oer&%y. 7 (2010). 12/0-1302. +'E+, hr&%an .,J5PE, chael , +"#-#E'+!+'E* #%efane, +E##$, chael, EE+, le9aner, "EE+, :alarala;o&, *

exposición química bioinorgánica final.pptx

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