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COMPLEMENT SYSTEM

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Page 1: COMPLEMENT SYSTEM - ntgc.in€¦ · Regulation of Complement System . Classical p athway Antige Il-antibody immune complexes Initiation Clq Antibody Amplification Cd convertases Lectin

COMPLEMENT SYSTEM

Page 2: COMPLEMENT SYSTEM - ntgc.in€¦ · Regulation of Complement System . Classical p athway Antige Il-antibody immune complexes Initiation Clq Antibody Amplification Cd convertases Lectin

Page 3: COMPLEMENT SYSTEM - ntgc.in€¦ · Regulation of Complement System . Classical p athway Antige Il-antibody immune complexes Initiation Clq Antibody Amplification Cd convertases Lectin

Page 4: COMPLEMENT SYSTEM - ntgc.in€¦ · Regulation of Complement System . Classical p athway Antige Il-antibody immune complexes Initiation Clq Antibody Amplification Cd convertases Lectin

INITIATION

Page 5: COMPLEMENT SYSTEM - ntgc.in€¦ · Regulation of Complement System . Classical p athway Antige Il-antibody immune complexes Initiation Clq Antibody Amplification Cd convertases Lectin

Major Complement components

Page 6: COMPLEMENT SYSTEM - ntgc.in€¦ · Regulation of Complement System . Classical p athway Antige Il-antibody immune complexes Initiation Clq Antibody Amplification Cd convertases Lectin

Classical Pathway

Page 7: COMPLEMENT SYSTEM - ntgc.in€¦ · Regulation of Complement System . Classical p athway Antige Il-antibody immune complexes Initiation Clq Antibody Amplification Cd convertases Lectin

Alternative Pathway

Page 8: COMPLEMENT SYSTEM - ntgc.in€¦ · Regulation of Complement System . Classical p athway Antige Il-antibody immune complexes Initiation Clq Antibody Amplification Cd convertases Lectin

Alternative Pathway

Page 9: COMPLEMENT SYSTEM - ntgc.in€¦ · Regulation of Complement System . Classical p athway Antige Il-antibody immune complexes Initiation Clq Antibody Amplification Cd convertases Lectin

Lectin Pathway

Page 10: COMPLEMENT SYSTEM - ntgc.in€¦ · Regulation of Complement System . Classical p athway Antige Il-antibody immune complexes Initiation Clq Antibody Amplification Cd convertases Lectin

TERMINATION

Page 11: COMPLEMENT SYSTEM - ntgc.in€¦ · Regulation of Complement System . Classical p athway Antige Il-antibody immune complexes Initiation Clq Antibody Amplification Cd convertases Lectin

Membrane Attack Complex (MAC)

Page 12: COMPLEMENT SYSTEM - ntgc.in€¦ · Regulation of Complement System . Classical p athway Antige Il-antibody immune complexes Initiation Clq Antibody Amplification Cd convertases Lectin

Summary of Complement Pathways

Page 13: COMPLEMENT SYSTEM - ntgc.in€¦ · Regulation of Complement System . Classical p athway Antige Il-antibody immune complexes Initiation Clq Antibody Amplification Cd convertases Lectin

Page 14: COMPLEMENT SYSTEM - ntgc.in€¦ · Regulation of Complement System . Classical p athway Antige Il-antibody immune complexes Initiation Clq Antibody Amplification Cd convertases Lectin

Page 15: COMPLEMENT SYSTEM - ntgc.in€¦ · Regulation of Complement System . Classical p athway Antige Il-antibody immune complexes Initiation Clq Antibody Amplification Cd convertases Lectin

Page 16: COMPLEMENT SYSTEM - ntgc.in€¦ · Regulation of Complement System . Classical p athway Antige Il-antibody immune complexes Initiation Clq Antibody Amplification Cd convertases Lectin

Regulation of Complement System

Page 17: COMPLEMENT SYSTEM - ntgc.in€¦ · Regulation of Complement System . Classical p athway Antige Il-antibody immune complexes Initiation Clq Antibody Amplification Cd convertases Lectin

Comparison of the established standard complement ... · crossmatch (FACS-CM) was developed (Garovoy et al., 1983). This method detects low antibody titers (Bittencourt et al., 1998),

Human Seminal Plasma Inhibition Antibody Complement … · 2014-01-30 · It may enhance pathogenesis of agents of sexually transmitted diseases. INTRODUCTION Highly effective biological

Complement-independent blistering mechanisms in bullous ... · antibody prevents disease induction. The aboveevidence indicate that complement activation is s essential for induction

A Novel Antibody against Human Properdin Inhibits the … · 2017. 8. 30. · A Novel Antibody against Human Properdin Inhibits the Alternative Complement System and Specifically

Host Cellular Immune Response to Pneumococcal Lung ... · also activates the classical complement pathway in the absence of antipneumolysin antibody (16). ... our model of bronchopneumonia

Complement system: key features, role of the C3 convertases and … · 2019. 2. 28. · The complement system Part of the innate immune system Also influences adaptive immune system

Type (II) Hypersensitivity. ( ( cytotoxic hypersensitivity ) Antibody directed against cell surface or tissue antigens interacts with complement and a

Degree Antibody-Independent Activation Classical ... · classical complement pathway. Kl strains of all three 0 serotypes were resistant to the alternative ... bacteria to cause meningitis

Complement Synthesis and attachment of specific antibody to invading microorganisms does not directly lead to destruction. It is a "label" that

LEUKOCYTE/ IMMUNE SYSTEM DISORDERS. VARIATIONS IN IMMUNE FUNCTION Fetal and Neonatal Immune Function l Antibody, phagocytic and complement functions

Complement-dependent and -independent aquaporin 4-antibody-mediated cytotoxicity … · 2017-01-03 · antibody-mediated cytotoxicity to astrocytes. In addition, pure AQP4 loss without

Structural Immunology of Complement Receptors 3 …opens up for a better understanding of complement in antibody-based biological therapy and certainly highlights the role of CR3 and

GENETIC BACKGROUND OF ANTIBODY DIVERSITY. STRUCTURE OF IMMUNOGLOBULINS/ANTIBODIES COMPLEMENT ACTIVATION BINDING TO CELLS DEGRADATION TRANSPORT Light chain

What Is Antibody-Mediated Rejection in Histologic Diagnosis in … · 2017-03-30 · of antigen-antibody reaction by complement system in liver, and the role of AMR in chronic graft

Immunoglobulin and complement deposition in skin of ... · patients with SLE had reactive antinuclear antibody (ANA)titres >1:32(BlondinandMcDuffie, 1970). Control studies were performed

LEPRA REACTION...hypersensitivity and produce antigen antibody immune complex reaction in the presence of complement system. • Immune complexes are precipitated in: Skin, eyes, joints,

2005 Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus

Opsonophagocytic Killing Activity ofRabbit Antibody to ... · Opsonophagocytic Killing Activity ofRabbitAntibodyto ... by the alternative pathway of complement (11), although some

ANTIGEN- ANTIBODY INTERACTIONS – II. COMPLEMENT FIXATION TEST Complement, a heat labile factor in normal serum is absorbed during combination of Ag

Processing by Convertases Is Required for Glypican-3- induced

EpCAM immunotherapy versus specific targeted delivery of drugsdro.deakin.edu.au/eserv/DU:30110157/macdonald-epcam... · complement components, regardless of the afﬁnity of the antibody

complement and complement deficiency

Role of Complement in MouseMacrophage Binding ... · Monoclonal antibody Ml8/2.a.8 was prepared using methods identical to those used to prepare M1/70. This rat IgG2a antibody recognizes

VARIABLE ANTIBODY-DEPENDENT ACTIVATION OF … · 03/11/2010 · VARIABLE ANTIBODY-DEPENDENT ACTIVATION OF COMPLEMENT BY FUNCTIONALIZED PHOSPHOLIPID NANOPARTICLE SURFACES Christine

Inhibition of Prohormone Convertases PC1/3 and PC2 by …molpharm.aspetjournals.org/content/molpharm/81/3/440.full.pdf · Inhibition of Prohormone Convertases PC1/3 and PC2 by 2,5-Dideoxystreptamine

Maturation of the Human Complement System€¦ · suggest that developmentally the complement system is a more primative biological defense mechanism than antibody. INTRODUCTION The

Introduction to Physiology: The Cell and General Physiology · Fc receptor Antigen Antibody Action. Antibody-Activated Phagocytosis bacterium Fc receptor opsonization. Complement

Complement-Mediated Neutralization of Dengue Virus ... · fever/dengue shock syndrome [DHF/DSS]) (2). Although the pathogenesisofDENVinfectionremainscontroversial,antibody-dependent

A Novel Antibody against Human Properdin Inhibits the ... · A Novel Antibody against Human Properdin Inhibits the Alternative Complement System and Specifically Detects Properdin

Complement, Chapter 5, App. 8 Proliferation ANTIBODY …jeeves.mmg.uci.edu/immunology/LecturePPT/LEC05PH.pdf · Complement, Chapter 5, App. 8 ... "presentation" Inflammation Killing

THE ROLE OF COMPLEMENT IN ACUTE ANTIBODY ...skin allografts could not be destroyed by injection of anti-donor antibodies. Acute antibody-mediated rejection (AAR) of established skin

Review Article The Role of Mannose-Binding Lectin in Severe Sepsis …downloads.hindawi.com/journals/mi/2013/625803.pdf · activates complement cascade via the antibody-independent

Complement Jan 25, 2006. Complement (C’) Complement Complement refers, historically, to fresh serum capable of lysing antibody (Ab)-coated cells. This

2014 -Antibody/Neutrophils/Complement

Antibody ormation F in ansfusion r T Therapynursing.ceconnection.com/ovidfiles/00129804-201803000-00002.pdf · networks of complement and lectin proteins are the next line of defense