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COLLEGE OF BIOTECHNOLOGY AND BIOENGINEERING300 Cheoncheon-Dong, Jangan-Gu, Gyeonggi-Do 440-746, Republic of KoreaTel. +82-31-290-5872 / Fax. +82-31-290-5879 / http://lifetech.skku.edu

COLLEGE OF BIOTECHNOLOGYAND BIOENGINEERING

http://biotech.skku.edu

Sungkyunkwan University was founded in 1398 as the highest national educational institute in the early years of the Joseon Dynasty in Korea. As the oldest university in East Asia, it has fostered leaders of our society for over 600 years. ‘수기치인 (修己治人),’ pronounced as ‘Su-Gi-Chi-In,’ SKKU’s main ideology, teaches that SKKU students strive to perfect themselves as leader and contribute to our society. This ideology is the fundamental principle by which SKKU brought up leaders of our society for over 600 years, thus contributing to evolution of our society. SKKU aims to educate future global leaders equipped with this ideology so that it will further contribute to the international society. Sungkyunkwan University, under the catch-phrase ‘Unique Origin Unique Future,’ continuously pursues to integrate its foundation philosophy with the modern technology with a view to cultivating global talents who will lead the 21st century. What the University has achieved in the past fifty years meets and exceeds that of the preceding five hundred and fifty years. We take pride in the University’s innovative spirit; as a result of the long efforts to place natural sciences on an equal footing with our strong foundation in humanities, we now operate two campuses: the Humanities and Social Sciences Campus and the Natural Sciences Campus. Based on a highly successful partnership with Samsung which has generously funded several core initiatives, the University has been rapidly developing and prospering since 1996.

CO

NTEN

TSDEAN’S MESSAGE 04

ORGANIZATION 05

Food Science and Biotechnology 06

Bio-Mechatronic Engineering 11

Genetic Engineering 17

Interdisciplinary Program of Biotechnology and Bioengineering (IPBB) 23

Institute of Biotechnology and Bioengineering 24

BK21 25

CAMPUS MAP 26

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Welcome to the College of Biotechnology and Bioengineering at the Sungkyunkwan

University.

College of Biotechnology and Bioengineering was established on the vision that

Sungkyunkwan University will lead the forefront education and research in the fields of life

science, biotechnology, biomedical sciences, bioengineering, and food biotechnology. Our

college comprises 3 departments and 1 interdisciplinary department : Department of Food

Science and Biotechnology, Department of Bio-Mechatronic Engineering, Department of

Genetic Engineering, and Department of Biotechnology and Bioengineering. As a leading

biotechnology group in major research universities, our mission is to effectively integrate

learning, discovery, and engagement. We, also reinforce education-industry ties to enhance

research efficiency and to maximize the proficiency of adding industrial value to the research

products. Through this interdisciplinary research and academic cooperation, we have

demonstrated our promising future.

In addition to offering high quality undergraduate education, our college offers excellent

graduate programs at the MS and PhD levels. Graduates from our advanced degree programs

are presidents of corporations, excellent researchers in industries, bureaucrats in related

fields and professors. Like our undergraduate students, our graduate students have the

opportunity to learn from the best faculty in the discipline. Beyond that, graduate students

participate in cutting edge research in the hopes of solving some of today’s most pressing

problems. We know that the best learning is experiential, and leads to a clear understanding

of how discoveries are made, how science is conducted, and how ideas are communicated.

The best learning is facilitated by faculty who are active in research and who can engage

students in the excitement of biotechnology and bioengineering. The best learning results in

alumni who are well-prepared to successfully pursue their chosen carriers. Undergraduate

students in our school are all welcomed to join this research-oriented educational program,

too. In order to support our students who are actively performing their research, we are

currently running 2 Brain Korea 21 programs which are supported by Ministry of Education,

Science and Technology ($500,000 per annum).

Our faculty, staff, and students are engaged with the communities of science and education,

the worlds of industry and business, and our alumni and friends. To each individual who joins

us, we promise opportunities to experience the excitement of biotechnology. We encourage

you to become a part of our team as a student, alumnus, corporate partner, scientific

collaborator, or a member of our faculty and staff. Join us on our journey of learning,

discovery, and commitment and enjoy the excitement of biotechnology and bioengineering.

Dean’s Message

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Organization

COLLEGE OF BIOTECHNOLOGY AND BIOENGINEERING

Dean

Administration

BK Teams

Food Science and Biotechnology

Bio-Mechatronic Engineering

Genetic Engineering

Interdisciplinary Program of

Biotechnology and Bioengineering (IPBB)

Core HRD-Team for Genetic Engineering

HRD Center for Next Generation Digital Production Process of New Bio-Materials

Faculty

Institute of Biotechnology and Bioengineering

Center for Biological Technology

Center for Medical and Engineering Research

Center for Korean Wild Ginseng Research

Center for Safety of Feeds and Livestock Products Research

Center for Human Motion Analysis

Food Science and Biotechnology

The department of Food science and Biotechnology is a discipline that deals with broad

aspects of food. Specifically, basic sciences, nutritional needs, processing of food for human

consumption, food safety, food packaging, food microbiology, food chemistry, and developing

functional foods lie in the area of Food science and Biotechnology.

Based on the fundamental science and biotechnology, exploring natural foods that can

prevent diseases, discovering how food components affect metabolism, screening and

developing novel and useful microbes and genes that can be utilized for biotechnology.

and identifying mechanism of lipid oxidation and antioxidants based on food matrix,

phototransformation of phytochemicals are investigated. Vigorous research is also undertaken

to explore the potential applications in biotechnology and food science. Research and

education on the basic sciences, functional food, nutrition, food microbiology, food chemistry,

food processing, packaging, food hygiene, safety of food, and biotechnology for production

of functional live stock are designed to provide technical information and assistance to the

consumers, food industries, research institutes, and government.

Dept. of Food Science and Biotechnology was established at 1976 and in 2004, to meet the

social request, renamed to Food science and biotechnology for combining Food science with

biotechnology. Dept. of Food Science and Biotechnology has history of 27 years and produced

800 undergraduates, 150 master’s, and 60 doctoral degrees. The graduates play significant

roles as experts in the variety of fields such as academics, industries, research institutes,

and government. Our department offers combined masters and doctorate program and also

provide research exchange programs with various research institutes and graduate schools.

As one of the most spotlighted scientific fields, this major is designed to provide students with

fundamental and applied knowledges in food science and biotechnology and achieve global

excellence in academics and industries.

Introduction

Vision

■ Specialization of curriculum in basic and applied sciences

■ Support for graduate

research and promotion of research exchange program

■ Development of training program to increase global competitiveness in biotechnology industries

Dept. Strategy

■ Cultivate global experts who can lead advancement of Food science and Biotechnology

Dept. Mission

■ Cultivating global excellence in Food science and Biotechnology

Dept. Vision

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Accomplishment

Professor Projects Support year

Ki-Moon Park

Construction of a regional specialization based on small-scale cultivation of mushrooms

Rural Development Administration,

Republic of Korea.2011-2013

Ki-Moon Park

Development of new biomaterials from egg shell membrane and nanopowder of biocompatibility

Small & MediumBusiness

Administration2011-2013

JaeHwan Lee

Study on the Dasik, a traditional Korea dissert with fortifying health-beneficial functionality

IPET 2012-2012

Jung-Hoon Yoon

Metagenome Resource BankNational Research

Foundation of Korea

2012-2017

Jung-Hoon Yoon

Investigation and screening project of domestic prokaryotes

National Institute of Biological Resources

2012-2014

Kye Won Park

Identification of new molecular mechanism in adipocyte differentiation and obesity by using a novel small molecule

National Research Foundation of

korea2011-2014

Kye Won Park

Studies and therapeutic application of Notch signaling in the obesity and type 2 diabetes

Korea Health Industry

Development Institute

2010-2012

Jaejoon Han

Development of innovative anti-insect packaging system for food application

Korean Food and Drug

Administration2011-2014

Jaejoon Han

D e v e l o p m e n t o f a n t i m i c r o b i a l food packaging material using a microencapsulation technique for safety assurance of fresh food

Ministry for Food, Agriculture, Forestry and

Fisheries

2011-2014

Jaejoon Han

Developing functional bio-plastic materials from biomass and biopolymer composite and their application for food packaging

Ministry of Education, Science

and Technology2011-2014

Projects (2010)

Publications (2010-2012) • Park KM, Jin YH, Lee KT, Lee WI, Nam SW, Han YK. Influence of Epimedium koreanum

on the performance of laying hens, egg quality, and fat soluble vitamin and cholesterol contents in the yolk. J. Medicinal Plants Research. 2010. 4(19) : 1971-1976

• Lee JL, An JM, Yang HJ, Kim BW, Park KM. Reparatory and preventive effects of oriental herb extract mixture (OHEM) on hyperuricemia and gout. Food Sci. Biotechnol. 2010. 19(2) : 517-524

• Cho JW, Jeong YS, Chun YJ, Kim HK, Kim MY, Kim BJ, Park KM, Kim JK, Kim JH, Cho SM. Skin hydration and collagen synthesis of AF-343 in HS68 cell line and NC/Nga mice by filaggrin expression and suppression of matrix metallopreteinase. Toxicol. Res. 2011. 27(4) : 225-229

• JuDong Yeo, Min Kyu Jeong, Chan Uk Park, and JaeHwan Lee. Comparing Antioxidant

Effectiveness of Natural and Synthetic Free Radical Scavengers in Thermally-oxidized Lard using DPPH Method. Journal of Food Science. 2010, 75, C258-C262.

• Min Hee Park, Min Kyu Jeong, JuDong Yeo, Hee-Jin Son, Chae-Lan Lim, Eun Jeung Hong,

Bong-Soo Noh, and JaeHwan Lee. Application of Solid Phase-microextraction (SPME) and Electronic Nose Techniques to Differentiate Volatiles of Sesame Oils Prepared with Diverse Roasting Conditions. Journal of Food Science. 2011, 76(1), C80-C88.

• Min Hee Park, Min Kyu Jeong, Mija Kim, and JaeHwan Lee. Modification of Isoflavone

Profiles in a Fermented Soy-food with Almond Powder. J Food Sci. 2012. 77(1), C125-134.

• Tae Soo Kim, Eric Decker, and JaeHwan Lee. Effects of chlorophyll photosensitization on the oxidative stability in O/W emulsion. Food Chem. 2012. 133(4), 1449-1455

• Lee, J. S., Kim, Y.-S., Park, S., Kim, J., Kang, S.-J., Lee, M.-H., Ryu, S., Choi, J. M., Oh, T.-K.

and Yoon, J.-H. Exceptional production of both prodigiosin and cycloprodigiosin as major metabolic constituents by a novel marine bacterium, Zooshikella rubidus S1-1. Appl. Environ. Microbiol. 2011 Jul, 77(14); 4967-4973.

• Kang, C.-H., Oh, K.-H., Lee, M.-H., Oh, T.-K., Kim, B. H. and Yoon, J.-H. A novel family VII esterase with industrial potential from compost metagenomic library. Microbial Cell Factories. 2011 May, 10:41.

• Yoon, J.-H., Kang, S.-J., Lee, S.-Y., Lee, J.-S. and Park, S. Ohtaekwangia koreensis gen. nov., sp. nov. and Ohtaekwangia kribbensis sp. nov., isolated from marine sand, deep-branching members of the phylum Bacteroidetes. Int. J. Syst. Evol. Microbiol. May, 61(5): 1066-1072.

• Yoon, J.-H., Kang, S.-J. and Lee, S.-Y. Salinimonas lutimaris sp. nov., a polysaccharide-degrading bacterium isolated from a tidal flat. Antonie van Leeuwenhoek. April, 101(4): 803-810.

• Park KW, Waki H, Choi SP, Park KM, Tontonoz P. The small molecule phenamil is a modulator of adipocyte differentiation and PPARgamma expression. JOURNAL OF LIPID RESEARCH. J Lipid Res. 2010, Sep 51(9), 2775-84

• Jung SR, Song NJ, Hwang HS, An JJ, Cho YJ, Kweon HY, Kang SW, Lee KG, Yoon K, Kim BJ, Nho CW, Choi SY, ParkKW. Silk peptides inhibit adipocyte differentiation through modulation of the Notch pathway in C3H10T1/2 cells. Nutr Res. 2011 Sep;31(9):723-30.

• Jung SR, Kim YJ, Gwon AR, Lee J, Jo DG, Jeon TJ, Hong JW, Park KM, Park KW. Genistein mediates the anti-adipogenic actions of Sophora japonica L. extracts. Med Food. 2011 Apr;14(4):360-8.

• Han J, Salmieri S, Le Tien C, Lacroix M. Improvement of water barrier property of paperboard by coating application with biodegradable polymers. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2010 Mar; 58(5); 3125-3131

• Han, J., Britten, M., St-Gelais, D., Champagne, C.P., Fustier, P., Salmieri, S. and Lacroix, M. Effect of polyphenolic ingredients on physical characteristics of cheese. FOOD RESEARCH INTERNATIONAL. 2011 Jan; 44(1); 494-497

• Han, J., Britten, M., St-Gelais, D., Champagne, C.P., Fustier, P., Salmieri, S. and Lacroix, M. Polyphenolic compounds as functional ingredients in cheese. FOOD CHEMISTRY. 2011 Feb; 124(4); 1589-1594

Patents (2008-2011)

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Extract of Rhodotus palmatus cultured broth and cosmetic composition comprosing the same for providing anti-wrinkle activity, Ki-moon Park, Korea, patent registered 10-0868784, 2008-11-07

Composition of matter having plant extracts to detoxifing of nicotine and dioxins, Ki-moon Park, Japan, patent registered, 4100623, 2008-03-28

Pellet Composite containing ultra fine calcium carbonate and method for preparaing same, Ki-moon Park, Korea, patent registered, 10-0948499, 2010-03-11

A novel Pleurotus eryngii var. ferulae strain DDL01 and method of producing it, Ki-moon Park, Korea, Patnet registered, 10-0954964, 2010-04-19

Nature biodegradable sheet containing starch and method fpor manufacturing the same, Ki-moon Park, Korea, patent registered, 10-0955024, 2010-04-20

Composition of matter having plant extracts to improve atopic dermatitis, Ki-moon Park, Korea, patent registered, 10-0986975, 2010-10-05

Novel Pleurotus eryngii var. ferulae Strains, Ki-moon Park, Korea, Patnet applied 10-2011- 0065104, 2011-06-30

New bacterial species Zooshikella rubidus producing red pigments and red pigments produced from it, Jung-Hoon Yoon, Korea, Patent registered 10-1132305, 2012-3-26

Novel gene encoding low temperature activated lipase derived from tidal flat metagenome and preparation method thereof, Jung-Hoon Yoon, Korea, Patent registered 10-0997735, 2010-11-25

Novel gene encoding esterase derived from tidal flat metagenome and preparation method thereof, Jung-Hoon Yoon, Korea, Patent registered 10-0986161 2010-10-1

Faculty members

ProfessorDegree PhD / 1986 / Sungkyunkwan UniversityPhone 031-290-7806 e-mail [email protected] - Studies on the physiological activity and nutritional composition of mushrooms - Development of functional materials for environmental health and disease prevention - Development of functional foods using cactus, pomegranate, pharmacognosy Ki-moon Park

Associate ProfessorDegree PhD / 2002 / The Ohio State UniversityPhone 031-290-7809e-mail [email protected] - Mechanism of lipids oxidation and antioxidant action - Phototransformation of phytochemicals - Development of new assays for lipid oxidation and antioxidant effectivenessJaeHwan Lee

Associate ProfessorDegree PhD / 1998 / Korea Advanced Institute of Science and Technology (KAIST)Phone 031-290-7800 e-mail [email protected] -Studiesonscreeningandidentificationofnovelbacterialspeciesfromenvironment -Studiesscreeninganddevelopmentofnovelandusefulmicrobesandmaterials -DevelopmentofnovelandusefulenzymesforbiotechnologyJung-Hoon Yoon

Associate ProfessorDegree PhD / 2004 / University of UtahPhone 031-290-7804 e-mail [email protected] -Identificationofosteogenicfactorsandtheirmolecularmechanismsinosteogenesis -Identificationofanti-adipogenicnaturalmaterials -StudiesandtherapeuticapplicationofNotchsignalingintheobesityandtype2diabetesKye Won Park

Assistant ProfessorDegree PhD / 2006 / Texas A&M UniversityPhone 031-290-7803e-mail [email protected] -Foodpreservationandsafetystudyusingthenaturalbioactivecompoundsandactive

packaging treatment -Developmentofeco-friendlybiodegradableplasticfilmsfromagriculturalby-productsfor

practical purposes -Evaluatingsafetyofpaper-basedmaterialsforfoodpackagingapplicationJaejoon Han

Bio-Mechatronic Engineering

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The purpose of Bio-Mechatronic Engineering (BME) is to carry out the basic and applied multi-disciplinary engineering researches in the fields of Biomedical Engineering including bio-system and biomechanics of human motion, and Mechatronic Engineering including automation engineering and bio-processing engineering. Bio-system disciplinary includes physiological modeling and simulation, rehabilitation engineering, artificial organ, bio-signal and image processing and biomaterials. Biomechanics of Human Motion disciplinary includes ergonomics and sports biomechanics. Automation Engineering disciplinary includes bio-production automation, earth moving vehicle, robotics, bio-sensor, signal analysis, and bio-image processing. Bio-Processing Engineering disciplinary bio-reactor design and bio-production process engineering.

The BME department offers 33 major courses toward undergraduate program including Introduction of Biomedical Engineering, Human Physiology, Biomechanics, Biomaterials, Tissue Engineering, Bio Materials, and Image Processing in the disciplinary of Biomedical engineering and Digital Circuit, Automatic control, Bio-Sensor engineering, Automatic control and Digital Circuit, Automatic Control, CAD/CAM, Robotics and Programming Language in the disciplinary of Mechatronics.

Cutting-edge interdisciplinary research aimed at improving the quality of human life is an important goal of the faculty of the Department of BME. Areas of concentration for individual faculty cover a wide range of fields within BME. The laboratory in BME associated with each faculty is listed here such as bio-system laboratory, bio-processing laboratory, bio-production system laboratory, biosensor and instrumentation laboratory, image processing and robotics laboratory, system automation laboratory and biomedical engineering laboratory.

The broad goal of BME program is to educate engineering students who will promote the human health by solving problems with living systems, and the knowledge toward the mechatronic system by solving problems with mechanics, electronics and computer.

Introduction

Vision

■ Bio-mechatronic specialist training, dramatically strengthening of research capacity

■ Biomedical engineering and mechatronic training is divided into subject matter experts

Strategy

■ Cultivate global leader with excellency in biotechnology and mechatronics in the era of bio-engineering

Mission

■ International competitiveness in biotechnology, mechanical and electronic engineering training of human resource

Vision

Professor Subject Support Year

Dong-HyukKeum

Development of new grain drying system using rice husk energy for RPC Rural Development Administration 2009-2012

Development of drying technology for sola salt

Korea Institution of Planning & Evaluation for Technology in Food, Agriculture, Forestry & Fisheries

2008-2011

Structural analysis of storage facilities using composition and volume of air Korea Forest Research Institute 2009-2011

Energy analysis for development of the energy efficient processing and engineering model for RPC


2009-2012

Kyou-SeongLee

Development of seeding machine for small grain Rural Development Administration 2009-2011

Development of low cost and high efficient soybean harvester and thresher Rural Development Administration 2008-2010

Development of self-propelled potato harvester


2008-2010

Development of IT oriented environment friendly cultivation and mechanization for a pear orchard


2009-2012

Chang-Hyun Choi

Development of food quality sensing technology for u-food system Korea Forest Research Institute 2010-2014

Development of simulation model and optimized operation programfor preprocessing system

Korea Forest Research Institute 2009-2011

Development of automated manual transmission(AMT) for improvement of tractor’s energy efficiency and convenience


2009-2012

Development of heating appliance suitable for Korean cuisine


2009-2011

Heon Hwang

Development of Inorganic Super-Hydrophilic Nano-Coating Solution for the PV Improvement of Solar Cell

Korea Institute for Advancement of Technology 2010~2011

Development of Highly Efficient Heat Absorbing Inorganic Functional Materials and Anti-Dirt, Self-cleaning Film

Small & Medium Business Administration 2009~2011

Development of Anti-Dirt and Durability Improvement Technology for Exterior Building Materials Using Atmospheric Pressure Plasma

Korea Institution of Construction & Transportation Technology Evaluation and Planning

2008~2013

Development of IT Oriented Environment Friendly Cultivation and Mechanization for a Pear Orchard


2009~2012

Dae-Weon Lee

Development of system for medium opration sprayer


2009-2012

Control and management system for welfare sows in outdoor group breeding system


2009-2012

Joung-Hwan Mun

Development of a musculoskeletal model and a seat of combine operater


2007-2010

Development of intelligence monitoring system for anesthesia level and facial nerve using electromyogram

Ministry of Healht & welfare 2010-2012

Development of All-In-One type multy function brain disease diagnosis & treatment system

Gyeonggi Research Institute 2009-2011

The study on the improvement of agricultural process for worker protection Rural Development Administration 2010-2012

Accomplishment

SelectedResearch

Projects (2006-2010)

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• Hong, S. J., L. A. Duc, J. W. Han, H. Kim, Y. H. Kim, D. H. Keum. 2008. Physical properties of rapeseed(II). Biosystem Eng. 33(3):173-178

• Kim, Y. H., J. W. Han, D. H. Keum. 2007. Desorption EMC models for rapeseed. Biosystem Eng. 32(6):403-407

• Han, J. W., D. H. Keum, H. Kim, S. J. Hong. 2007. Development of a rice circulating concurrent-flow dryer(II)-validation of drying simulation model-. Biosystem Eng. 32(5):309-315

• Lee, K. S., Lee, D. H., Sudduth, K. A., Chung, S. O., Kitchen, N. R., Drummond, S. T. 2009. Wavelength identification and diffuse reflectance estimation for surface and profile soil properties. Transactions of the ASABE 52(3):683-695.

• Park, W.Y., Y. C. Chang, S. S. Lee, J. H. Hong, J. G. Park, K. S. Lee. 2008. Prediction of the tractive performance of a flexible tracked vehicle. Journal of Terramechanics 45:13-23.

• L.G. Huan, S. Choi, S.I. Cho, M.H. L, H. Hwang, 2009. Automatic extraction of lean-tissue Contours fo r beef quality grading, Biosystems Engineering, 102[2]

• Kwon, K. H., J. W. Jeong, J. H. Kim, Y. J. Kim, and C. H. Choi. 2009. Thermal storage and thermodynamic characteristics of phase change materials slurries. Food Science and Biotechnology 18(6):1392-1397.

• Choi, C. H., J. D. Kim, T. H. Kim, J. H. Mun, Y. J. Kim. 2009. A study on visibility evaluation for cabin type combine. Journal of Biosystems Engineering 34(2):130-135.

• Kim, Y. J., E. H. Nam, C. H. Choi, J. D. Kim. 2008. A study on measurement of blood pressure by partial least square method. Journal of Biosystems Engineering 33(6):408-415.

• D.H. Im, S.. Kim, S.I. Cho, S.C. Chung, H. Hwang, 2008. Multi-functional Automated Cultivation for House Melon -Development of Tele-robotic System-, J. of Biosystems Engineering, 33[3], 186-195.

• Hwang H., 2008. Development of Robotic Harvest System for Bench-type Strawberry Cultivation, ISMAB 2008 Symposium pp11-18

• Seo, K. W., B. R. Min, H. T. Kim, S. Y. Lee, D. W. Lee. 2008. Classification of esophagitis grade by neural network and texture analysis. Journal of Mechanical Science and Technology. 22(12):2475-2480

• Kim, W., B. R. Min, D. W. Lee. 2007. A stereo-vision system for 3D position recognition. Journal of Biosystems Engineering. 32(1)

• Lee, D. W., K. W. Seo, B. R. Min. 2006. Discrimination between cancer and normal tissue using near infrared spectroscopy. IFMBE Proceedings WC. Vol.14, pp.1232-1235

• Choi, A. R., T. S. Yun, K. S. Lee, K. K. Min, H. Hwang, K. Y. Lee, E. C. Oh and Joung H. Mun. 2009. Asymmetric loading of erector spinae muscles during sagittally symmetric lifting. Journal of Mechanical Science and Technology. Vol. 23, pp.64-74

• Shin, K. Y., K. Y. Lee and Joung H. Mun. 2009. Estimating muscle fatique of the biceps brachii using high to low band ratio in EMG during isotonic exercise. International Journal of Precision Engineering and Manufacturing. Vol. 10, No. 10, pp. 1-10

• Rim, Y. H., A. R. Choi, S. S. Lee, K. K. Min, D. H. Keum, C. H. Choi and Joung H. Mun. 2009. The comparison of joint kinematic error using the absolute and relative coordinate systems for human gait. Journal of Mechanical Science and Technology. Vol. 22, No. 1, pp. 161-169

SelectedPublications(2006-2010)

SelectedPatents

(2006-2010)

Automatic quality grading and weighting system for chicken carcass, Hwang, H., Korea, Registration No. 10-0948406

Chicken carcass individual managing system, Hwang, H., Korea, Registration No. 10-0919462

End-effector for harvesting a pepper, Lee, D. W., Korea, Registration No. 10-0958039

Apparatus for cutting a pepper, Lee, D. W., Korea, Registration No. 10-0834706

A real-time portable system for predicting raw milk, Choi, C. H., I. H. Park, J. M. Kim, Y. J. Kim. Korea, Registration No. 10-2008-0048253

Visible/Near-infrared spectrum analysis software. Choi, C. H., Y. J. Kim, J. D. Kim. Korea, Korea Copyright Commission. Registration No. 2008-01-122-001996

A diagnostic system for joint and muscle disorders and a diagnostic method thereof, Mun, J. H., Korea, Registration No. 10-2009-0105053

A method and apparatus for expressing the variation of volume in human skin for the computer graphic animation, Mun, J. H., Korea, Registration No. 10-2008-0103734

New calibration method of multi-view camera for a optical motion capture system, Mun, J. H., Korea, Registration No. 10-2008-0068156

Camera adhesion type image processing and data transmission apparatus for optical motion capturing, Mun, J. H., Korea, Registration No. 10-2008-70136

Coating Film, Hwang, H., Korea, Registration No. 10-0777606

Coating Materials, Hwang, H., Korea, Registration No. 10-0777607

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Faculty members

ProfessorDegree PhD / 1988 / Seoul National UniversityPhone 031-290-7823 e-mail [email protected] - A Study of Soil-Wheel System for Identifying the Dimension of Pertinent Soil Parameter -WavelengthIdentificationandDiffuseReflectanceEstimationforSoilProperties - Construction of the Soil Bin System for the Evaluation of Soil-Machine System PerformanceKyou-Seung Lee

ProfessorDegree PhD / 1988 / Iowa State UniversityPhone 031-290-7824 e-mail [email protected] -MeasurementSystemforCombineDiagnoses -AutomaticGuidanceSystemforCombineUsingDGPS -PredictionofQualityParametersofAgriculturalProductionby

Visible/Near-infraredSpectroscopyChang-Hyun Choi

ProfessorDegree PhD / 1988 / Louisiana State UniversityPhone 031-290-7825 e-mail [email protected] Research -IntelligentTele-RoboticAutomationSystem -RoboticMonitoringandControlSystemforSpatio-temporalPlantGrowthandEnvironment - Multi-Functional Smart Inorganic Nano Coating Materials and Bio-Sensor Application - System for Plant Factory and Energy Saving System Technology Heon Hwang

ProfessorDegree PhD / 1990 / North Ccrolina State UniversityPhone 031-290-7826 e-mail [email protected] - Versatile Digital Endoscope -RoboticMilkingSystem - Three-dimensional lmage Processing & Tracking SystemDae-Weon Lee

Faculty members

ProfessorDegree PhD / 1998 / University of IowaPhone 031-290-7827 e-mail [email protected] Research -DevelopmentofMedicalUnifiedSolutionUsing3DImageFusion -DevelopmentofaMusculoskeletalModelandaSeatofCombineOperater - Development of Intelligence Monitoring System for Anesthesia Level and

Facial Nerve Using ElectromyogramJoung-Hwan Mun

Emeritus ProfessorDegree Ph.D / 1979 / Kansas State UniversityPhone 031-290-7821 e-mail [email protected] - Development of quality improving technology of agricultural products. - Nondestructive inspection technology of agricultural products.Yong-Kook Lee

Emeritus ProfessorDegree PhD / 1979 / Seoul National UniversityPhone 031-290-7826 e-mail [email protected] - Post-harvest Process Engineering - Simulation and Optimization of Drying and Storage System for Cereal Grains -SimulationandOptimizationofPrecoolingSystemforFruitsandVegetablesDong-Hyuk Keum

Genetic Engineering

Genetic engineering is a term for the process of isolation, manipulation and reintroduction of genes of interests into cells or model organisms. It has helped us overcome many challenges humankind face; food, health and environmental problems. Through genetic engineering. we have been able to develop new crops that are more nutritious, disease-resistant by introducing a novel trait. It has also been use to develope microorganisms that produce many medically useful proteins such as insulin and anti-cancer drugs, detoxify industrial waste and provide alternate fuel sources.

The department of Genetic Engineering offers a BSc through a comprehensive curriculum, which equips students with basic knowledge and practical exercise in diverse biotechnology disciplines. These include molecular biology, protein engineering, biochemistry, microbiology, genetics, plant biology stem cell biology, immunology. Graduate students are encouraged to acquire familarity with advanced research techniques and up-to-date ideas in depth, and learn how to write and publish a research paper in international top-tier journals. The department meets the growing need for specialists in a variety of technological fields of biology.

Introduction

Vision

■ Strengthning professional education and research capabilitites in Genetic Engineering

■ Development of novel biomaterials based on recombinant DNA technology

Strategy

■ Nurturing key specialist playing a leading role in the biotechnology era

Dept. Mission

■ Fostering world class talented students in the field of Biotechnology

Dept. Vision

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Professor Projects Support year

Suk-Tae Kwon

Development of DNA modifying enzymes for the research and diagnosis

The Ministry of Land, Transportation and

Maritime Affairs2004-2013

Sukchan Lee

Development of forecasting, diagnosis and control techniques of whiteflies that transmit plant virus disease

Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry

and Fisheries

2012-2016

Sukchan Lee

Development of GM chrysanthemum resistant to viroids

Rural Development Administration

2011-2014

Sukchan Lee

A verification of antiviral activity in transgenic chicken using nucleic acid hydrolyzing antibody


2011-2014

Sukchan Lee

Development of detection system for TYLCV strain

NPQS 2011-2012

Dae-Hyuk Kweon

Development of yeast strains for production of bioplastic precursors

Ministry of Land, Transport and Maritime

Affairs2010-2013

Dae-Hyuk Kweon

Soluble Nanostructure of water-insoluble drugs mimicking nascent high density lipoprotein assembly

National Research Foundation of Korea

2010-2013

Dae-Hyuk Kweon

Membrane fusion by SNARE proteins and development of small molecule Botox

Ministry of Health and Welfare

2011-2013

Keejung Yoon

Study of regulatory factors on stemness and differentiation of human umbilical cord blood CD34+ cells to immune cells


2009-2012

Keejung Yoon

Ultrasound image-guided gene delivery technology to early stage (E8) murine embryonic brain


2009-2013

Keejung Yoon

Functional analysis of a novel Notch signaling pathway modulator


2012-2015

Jae Youl Cho

Understanding the regulatory role of Syk in MyD88 function, and its application for novel anti-inflammatory drug development


2010-2013

Jae Youl Cho

Regulatory role of actin post-translational modification on TLR-mediated uinflammatory signaling and its application for finding new target molecule


2011-2014

Jae Youl Cho

Application of plant resources from Miyanmar

Korea Institute of Biological Resources

2011-2018

Jae Youl Cho

Understanding molecular inhibitory mechanism of inflammation regulatory proteins TBK1/IRF-3 and p38/ATF-2 by Korean red ginseng-derived diol type saponins

Korea Ginseng Society

2012-2014

Jeong Su Oh

Study of genome reprogramming during embryo development to establish the novel method for stem cell generation


2012-2014

Accomplishment

Research(2012)

Publications (2010-2012)

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• Cyclic adenosine monophosphate (cAMP)-induced histone hyperacetylation contributes to its antiproliferative and differentiation-inducing activities. Yoo S, Lee YG, Kim JH, Byeon SE, Rho HS, Cho JY, Hong S. Z Naturforsch C. 2012 Mar-Apr;67(3-4):222-32.

• Syk/Src pathway-targeted inhibition of skin inflammatory responses by carnosic acid. Oh J, Yu T, Choi SJ, Yang Y, Baek HS, An SA, Kwon LK, Kim J, Rho HS, Shin SS, Choi WS, Hong S, Cho JY. Mediators Inflamm. 2012;2012:781375. Epub 2012 Apr 10.

• Improved thermostability and PCR efficiency of Thermococcus celericrescens DNA polymerase via site-directed mutagenesis. Kim KP, Cho SS, Lee KK, Youn MH, Kwon ST. J. Biotch. 2011; 155: 156-163.

• Cloning, expression, and PCR application of DNA polymerase from the hyperthermophilic archaeon, Thermococcus celer. Kim KP, Bae H, Kim IH, Kwon ST. Biotechnol. Lett. 2011; 33: 339–346.

• Phylogenetic lineage of Tobacco leaf curl virus in Korea and estimation of recombination events implicated in their sequence variation. Park J, Lee H, Kim MK, Kwak HR, Auh CK, Lee KY, Kim S, Choi HS, Lee S. Virus Research. 2011 Aug:159(2):124-131.

• Agroinoculation of Nicotiana benthamiana with cloned honeysuckle yellow vein virus isolated from Lonicera japonica. Lee G, Kim S, Jung J, Auh CK, Choi E, Chang M, Lee S. Archives of Virology. 2011 May:156(5):785-791.

• Jae-Yoon Shin, Yoo-Soo Yang, Paul Heo, Ji-Chun Lee, Byung-Je Kong, Jae-Yeol Cho, Kee-Jung Yoon, Cheol-Su Shin, Jin-Ho Seo, Sung-Gun Kim, and Kweon DH (2012) pH-responsive high density lipoprotein-like nanoparticle to release paclitaxel at acidic pH for cancer chemotherapy, International Journal of Nanomedicine, 7, 2805-2816.

• Yoo-Soo Yang, Jae Yoon Shin, Jung-Mi Oh, Chang Hwa Jung, Yunha Hwang, Se-Hyun Kim, Jun-Seob Kim, Kee-Jung Yoon , Ji-Young Ryu, Jaeil Shin, Jae Sung Hwang, Tae-Young Yoon, Yeon-Kyun Shin and Kweon DH (2010) Dissection of SNARE-driven membrane fusion and neuroexocytosis by wedging small hydrophobic molecules into the SNARE zipper, PNAS, 107(51) 22145-22150.

• J. Jang, J. Lee, S-T Kim, K.-Y. Lee, S.-T. Kwon, S. Kim, K. Yoon (2012) Polycation-mediated enhancement of retroviral transduction efficiency depends on target cell types and pseudotyped Env proteins: Implication for gene transfer into neural stem cells. Neurochemistry International, 60:846-51.

• M. Yang, J. Hong, and K. Yoon (2011) Among gamma-secretase substrates Notch1 alone is sufficient to block neurogenesis but does not confer self-renewal properties to neural stem cells. Biochemical and Biophysical Research Communications 404:133-138.

• Akt Cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effects. Lee JY, Lee YG, Lee J, Yang GJ, Kim AR, Kim JY, Won MH, Park J, Yoo BC, Kim S, Cho WJ, Cho JY. J Biol Chem. 2010 Mar 26; 285(13): 9932-9948.

• 3-(4-(tert-Octyl)phenoxy)propane-1,2-diol suppresses inflammatory responses via inhibition of multiple kinase. Yu T, Shim J, Yang Y, Byeon SE, Kim JH, Rho HS, Park H, Kim TW, Sung GH, Rhee MH, Cho JY. Biochemical Pharmacology 2012 Jun. 1; 83(11): 1540-1551.

• Novel signaling mechanisms in the ovary during oocyte maturation and ovulation. Conti M, Hsieh M, Musa Z. A, OhJS. Mol Cell Endocrinol. 2012 Jun 5;356(1-2):65-73.

• Protein tyrosine kinase Wee1B is essential for metaphase II exit in mouse oocytes. Oh JS, Susor A, Conti M. Science 2011 Apr 22;332(6028):462-5.

Patents( 2006-2012)

Anticancer effect of Surfactin from Bacillus subtilis on colon cancer cells, Sungyoul Hong, Korea 10-2007-0077882 2007-08-02

Primer set for detecting Curtovirus and method for detecting Curtovirus using the same, Sukchan Lee, Korea 10-2012-0043927 2012-05-07

Primer sets for detecting Begomovirus and method for detecting Begomovirus using the same, Sukchan Lee, Korea 10-2012-0043924 2012-05-07

Primer composition for loop-mediated isothermal amplification reaction for detecting Honeysuckle Yellow Vein Mosaic Virus comprising specific primer set and method for detecting Honeysuckle Yellow Vein Mosaic Virus, using the primer set, Sukchan Lee, A patent application in Korea 10-2011-0114825 2011-11-04

Primer Sets for Detecting Begomovirus Beta-satellite DNA and Method for Detecting Begomovirus Beta-satellite DNA Using The Same, Sukchan Lee, A patent application in Korea 10-2011-0108063 2011-10-21

Synthetic peptides that regulate neurotransmitter release, Dae-Hyuk Kweon, Korea 0-2007-0106584 2007-10-23

Flower extracts for regulating SNARE complex formation, Dae-Hyuk Kweon, Korea 0-2007-0106592 2007-10-23Polyphenol compoundsregulate neurotransmission, Dae-Hyuk Kweon, PCT/KR2008/001400 2008-03-12

DNA polymerase derived from Thermococcus marinus and its use. Suk-Tae Kwon, Korea 10-2008-0123299, 2008-12-05

The method for producing transgenic animals using ultrasound image-guided gene delivery technique. Keejung Yoon, Korea, patent applied 10-2010-0139050, 2010-12-30.

The mothod for screening transgenic animals generated by ultrasound image-guided gene delivery technique using in vivo imaging of reporter gene expression. Keejung Yoon, Korea, patent applied 10-2010-0139051, 2010-12-30.

Method for creating Nanoarchaeum equitans DNA polymerase of A523R mutant and its PCR applications. Suk-Tae Kwon, Korea 10-2009-0097261, 2009-10-13

Cloning, expression, purification and characteristics of Thermococcus guaymasensis DNA polymerase gene and its use of PCR application. Suk-Tae Kwon, Korea 10-0969477, 2010-07-02

Method for preparing active Nanoarchaeum equitans DNA polymerase and the active DNA polymerase prepared by the method. Suk-Tae Kwon. US Patent, Patent No. US 7,749,732 B2, 2010-07-06.

A novel hot-start PCR based on the protein trans-splicing of Nanoarchaeum equitans DNA polymerase. Suk-Tae Kwon. US Patent, Application No. 13/306,915, 2011-11-29.

Method for creating Nanoarchaeum equitans DNA polymerase of A523R mutant and its PCR applications. Suk-Tae Kwon, Korea, Patent No. 10-1105271, 2012-01-05

Thermococcus pacificus DNA polymerase variant, and uses thereof. Suk-Tae Kwon, Korea Patent, Application No. 10-2012-0035330, 2012-04-05

Method for creating Nanoarchaeum equitans DNA polymerase of A523R mutant and its PCR applications. Suk-Tae Kwon, Korea, Patent No. 10-1105271, 2012-01-05

Thermococcus pacificus DNA polymerase variant, and uses thereof. Suk-Tae Kwon, Korea Patent, Application No. 10-2012-0035330, 2012-04-05

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Faculty members

ProfessorDegree PhD / 1987 / The University of Tokyo, JapanPhone 031-290-7863 e-mail [email protected] - DNA modifying enzymes from extremophiles - Screening of new DNA polymerases and DNA ligases from hyperthermophiles -Developmentofmutantenzymesbysite-directedmutagenesisandrandommutationsSuk-Tae Kwon

ProfessorDegree PhD / 1986 / Sungkyunkwan UniversityPhone 031-290-7862 e-mail [email protected] - Enzymology and physiological functions of posttranslational modification of proteins

byProtein Isoaspartyl/D-aspartylmethyltransferases inrepairofproteinsandcellularprocesses, including aging and apoptosis.

-Pathophysiologicalfunctionsofnitricoxidesynthasesincancerandinflammation. - Mechanism of cancer and screening of anticancer activities.Sungyoul Hong

ProfessorDegree PhD / 1987 / Kyushu UniversityPhone 031-290-7864e-mail [email protected] - Production of useful proteins using transgenic silkworms -Genetherapyforinsulin-dependentdiabetesDongsang Suh

ProfessorDegree PhD / 1995 / The Ohio State UniversityPhone 031-290-7866 e-mail [email protected] - Molecular plant-geminivirus interactions - Translational research : Side effect alleviation of cancer patients -Antiviralproteindevelopment:NucleicacidhydrolyticcatalyticantibodySukchan Lee

Faculty members

Assistant ProfessorDegree PhD / 2007 / GISTPhone 031-290-7865e-mail [email protected] - Signal pathway involved in the meiotic cell cycle -Epigeneticreprogrammingofchromatinduringearlyembryogenesis -EstablishmentofembryonicstemcellJeong Su Oh

Associate ProfessorDegree PhD / 2001 / Seoul National UniversityPhone 031-290-7869 e-mail [email protected] -RegulationofSNARE-drivenmembranefusion -SNARE-alphasynucleininteraction -Understandingbacterialpersistencetoantibiotics -Antibody-drugconjugatesDae-Hyuk Kweon

Associate ProfessorDegree PhD / 1999 / Seoul National UniversityPhone 031-290-7867e-mail [email protected] -Regulationofneuralstemcellsandbraindevelopment - Stem cell therapy using induced pluripotent stem cells -NeuroimmunologyofbraininfectionsandcancersKeejung Yoon

Associate ProfessorDegree PhD / 2001 / University College LondonPhone 031-290-7868e-mail [email protected] -Studyoffunctionalroleofcellcytoskeletonininflammatoryandtumorgenicresponses -Understandingofsignaltransductionpathwayininflammatorysignaling -Developmentofanti-inflammatoryandanti-cancerdrugsJae Youl Cho

Interdisciplinary Program of Biotechnology and Bioengineering (IPBB)

Interdisciplinary Program of Biotechnology and Bioengineering (IPBB) in Food Science and Biotechnology (FB), Bio-Mechatronics Engineering(BME) and Genetic Engineering (GE) prepares students for careers as research scientists, educators and medical doctors in an academic or industrial environment. IPBB is interdisciplinary in nature and includes the combined talents of honored undergraduate students and faculty members from three Departments.

- Food Science and Biotechnology - Bio-Mechatronic Engineering- Genetic Engineering

IPBB offers a course of study leading to the Bachelor’s degree of double major. Research training is very diverse and major areas of study include: Food Engineering, Food processing, Industrial Fermentation, Food safety, Obesity, Biodynamics, Biomechtronics development, Robotics Technology, Single motion units, 3D-Image Analysis, Electro-mechatronics, Human Motion Analysis, Cancer Biology, Cell Biology, Developmental Biology, Molecular Medicine, Molecular Neurobiology, Plant Molecular Biology and Virology.

IPBB emphasizes an integrative approach to the discipline, encompassing the Biotechnology and Bioengineering. A typical undergraduate program begins with an intensive study consisting of core courses in food biotechnology, mechatronics, molecular biology and biochemistry, followed by some additional elective coursework.

However, the bulk of training involves laboratory research and internship programs. Most students perform lab rotations before graduation.

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Institute of Biotechnology andBioengineering

Aim of establishment

The academic depth and the range of applications in the related fields of Biotechnology and Bioengineering have been increasing through cooperation with the science of agriculture and fisheries, oceanography, medical science, pharmacentical science and engineering fields.

Biotechnology and Bioengineering is rapidly diversifying its research areas and becoming high technology from the production, improvement and conservation of biological resources, hygiene and safety of food resources to the technology of laborsaving and industrialization of bio-industrial processes.

Because of these characteristics of biotechnology, it is required to build the creative research capacity in each field of studies and activate interdisciplinary and joint research among the industry-university-institute collaboration. In order to meet these requirements systematically and institutionally, Sungkyunkwan University 『Institute of Biotechnology and Bioengineering』 was established.

Our institute is to contribute to the development of 21st century biotechnology and related industries focusing on development of new bioactive food and organisms, hygiene and safety diagnosis and prevention of biological resources, securement and development of new genetic resources, building the foundation of industrialization technology and digital distribution system of biological production processes, and eco-friendly production technology of biological resources.

Institute of Biotechnology and Bioengineering is to contribute to the advancement of biotechnology through the scientific research and the development of technology in the related fields of biotechnology.

Research centers involved in Institute of Biotechnology and Bioengineering

- Center for biological technology- Center for medical and engineering research- Center for Korean wild ginseng research- Center for safety of feeds and livestock products research- Center for human motion analysis

Research performances and scholarly activities

- Apply and manage for domestic and international research grants- Support for seminars in the university- Support for workshops in the department- Publish biotechnology research periodicals.

Brain Korea 21

Brain Korea 21

To nurture world class graduate schools and to foster excellent researchers, Brain Korea 21 is a high-quality human resource nurturing program designed to aid the candidates in postgraduate and advanced-level research (Homepage: http://bk21.skku.edu)

Two BK 21 Teams in College of Biotechnology and Bioengineering

Core HRD-Team for Genetic Engineering Team Director : Suk-Tae Kwon, Ph.D / Genetic EngineeringHomepage : http://bk21.skku.edu/gene

HRD Center for Next Generation Digital Production Process of New Bio-Materials Team Director : Ki-Moon Park, Ph.D / Food Science and BiotechnologyHomepage : http://bk21.skku.edu/fbtech

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Vision of phase 2, BK21 project

Fostering Globalized human Resources“Increasingeach division to a world-classresearch-oriented university”

Human-Knowledge focused strategy

Developing World-classExpert Groups

▪Nurturingworld-classexperts in technologyies that have a great potential for future growth.

▪Stablyandsteadilyproducingnext generation scholars basicscience,humanitiesandsocial science

Developing RegionalGraduate Schools that willlead Regional Innovation

▪Enhancingregionalgraduateschools’researchcapabilitiesthrough specialization

▪FocuseddevelopmentofregionalR&Dhumanresources cluster

Developing RegionalGraduate Schools that willlead Regional Innovation

▪Enhancingregionalgraduateschools’researchcapabilitiesthrough specialization

▪FocuseddevelopmentofregionalR&Dhumanresources cluster

Stronger Korea with Enhanced Human Capital

CAMPUS MAP

Outdoor parking spaceShuttlebus stopTicket booth

01 Front Gate

02 Auditorium

03 Medical School

04 Tennis Court

05 Environment Plant

06 School of Pharmacy

07 Research Complex 1

08 Research Complex 2

09 Architecture Environment Lab

10 Engineering Lab

11 Engineering Lab

12 Engineering Lab

13 Building Maintenance office

14 Power Plant

15 Bio-Mechatronic Eng. Lab.

16 Bio-engineering Lab.

17 Engineering Building 1






23 Natural Science 1

24 Natural Science 2

25 General Studies

26 Biotechnology and Bioengineering 1

27 Biotechnology and Bioengineering 2

28 Shops & Services Center

29 Suseonggwan (Gymnasium Complex)

30 Student Center

31 Gymnasium

32 Dormitory

33 Ingwan (Dormitory)

34 Uigwan (Dermitory)

35 Yegwan (Dormitory)

36 Jigwan (Dormitory)

37 Guest House

38 Unyong-jae

39 ROTC

40 Samsung Library

41 Baseball Field

42 BBaseball Diamond

43 Basketball Field

44 Football Field

45 DRC

46 Semiconductor

47 Chemistry

48 North Gate

49 West Gate

50 Northwest Gate

COLLEGE OF BIOTECHNOLOGY AND BIOENGINEERING

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COLLEGE OF BIOTECHNOLOGY AND BIOENGINEERING300 Cheoncheon-Dong, Jangan-Gu, Gyeonggi-Do 440-746, Republic of KoreaTel. +82-31-290-5872 / Fax. +82-31-290-5879 / http://lifetech.skku.edu

COLLEGE OF BIOTECHNOLOGYAND BIOENGINEERING

http://biotech.skku.edu

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