brto /parto indications and outcomes - gest 2015 /parto indications and outcomes saher sabri, md...
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BRTO /PARTO
Indications and outcomes
Saher Sabri, MD
Associate Professor of Radiology and Surgery
Division of Interventional Radiology
University of Virginia Health System
Saher Sabri, M.D.
• Speakers Bureau: W.L.Gore & Associates, Abbott
Disclosures
W.L. Gore- Speaker
RTO Indications
To treat encephalopathy
GV bleed with contraindication to TIPS
( ex. Encephalopathy)
Continued GV bleed after TIPS
optimization ( RTO vs antegrade GV
sclerosis)
? Isolated GV bleed. No EVs or ascites.
Outcomes- Technical success
568 BRTO patients-Meta-analysis
Technical success rate is 91%
Complete obliteration rate is 93%
Partial obliteration is more common in complex varices
( 3 or more afferent veins) Takaji et al (AJR 2011)
Technical and clinical failures were routinely treated
with endoscopic NBCA injection
Saad et al CVIR 2013
OUTCOMES- Rebleeding
The GV rebleed rate after successful BRTO procedure
was 3.2–8.7 %
For all types of variceal rebleed rate reached 19–31 %
The rate of exacerbation of existing EVs
1 year is 27–35 %
2 years 45–66 %
3 years 45–91 %
EV bleeding occurred in in 17–24 %
Aggressive surveillance for EVs is needed
Rebleeding TIPS vs BRTO - Sabri et al JVIR 2013
27 TIPS and 22 BRTO for GVs TIPS with embolization of afferent veins (coils and AVP)
Technical success 100% TIPS and 93% BRTO
Complications 4% TIPS 9% BRTO
Encephalopathy 15% TIPS , 0% BRTO
1 year Rebleeding from a GV source 11% TIPS ,
0% BRTO (p 0.2)
2 TIPS dysfunction and one continued
bleeding despite TIPS optimization
Outcome
Author Patients (n) Technical success
(%)
Rebleeding rate
(%)
Complete
obliteration rate
(%)
Cho et al 49 84 0 100
Hiraga et al 34 97 3 91
Kitamoto et al 24 96 9 88
Arai et al 11 100 9 91
Ninoi et al 78 87 0 95
Kanagawa et al 32 100 0 97
Sabri et al 22 91 0 89
Updated UVA 70 94 2 92
Gown et al
(PARTO)
73 100 2 98
PARTO (Gwon et al JVIR 2015)
73 patients ( 57 GV bleeds and 16 HE)
Technical success 100%
AVP II ( 8-22 mm)- 70 only had one plug
Rebleeding 1/73
Complete obliteration at 3 months 98.6%
All HE had resolution of symptoms and decrease in Ammonia
level (p<.001)
ZERO complications
PARTO
Chang et al. (Korean J Rad) 19 pts . 95% tech success
Acute complications included fever (n = 2), fever and
hypotension (n = 2; one diagnosed adrenal insufficiency), and
transient microscopic hematuria (n = 3)
Obliteration rate 84%
Kim at al CVIR Jan 2016
Retrospective . 95 patients ( follow up available
on 70 )
BRTO with EO in 49 patients. BRTO with STS
foam in 25. PARTO in 21
Technical success was 95% (94% BRTO, 100%
PARTO)
Procedure time of PARTO was significantly
shorter than those of other two BRTO
procedures (P<0.017).
More complications with EO , including one
mortality from DIC.
Kim at al CVIR Jan 2016
3 cases of failure to obliterate GVs in BRTO with EO
group. None with STS
4 cases of failure with PARTO. (including 2 cases of
rebleeding )
At 1 YEAR 81 % obliteration rate for PARTO
Statistical difference of gastric varices recurrence
between two BRTO procedures and PARTO (P<0.05).
Conclusion: BRTO using STS foam and PARTO are better
than BRTO using EO in terms of complication or
procedure time. However, PARTO showed frequent
recurrence of gastric varices during the long-term
follow-up compared to BRTO.
OUTCOMES- Portal HTN Exacerbation
Development of ascites (0–44 %)
hepatic hydrothorax (0–8 %)
Hypertensive gastropathy (5–13 %)
In our experience 4/70 ( 6%) required
subsequent TIPS to treat complications of
portal HTN
Tanihata et al showed that 58 % of patients
have > 5 mmHg increase in PSG ( 58%) and
were associated with EV exacerbation
Effect of RTO on liver function
The bilirubin rises significantly (P = .007) within days
after RTO
The MELD score significantly improved 3-4 months
post-RTO (from 14.1 to 10.7, P = .0008).
Effect is transient and most patients return to baseline
by 6-9 months
The Child Pugh score did not change significantly (from
7.6 to 6.7, P = .063).
Ascites worsened in 31% of patients
Saad et al Vasc Endovasc Surgery 2013
RTO for Encephalopathy
65 patients reported in the literature
Immediate response is 86-100%
Long term improvement in HE 100%
Serum Ammonia levels of 127. mmol/L
decreased significantly to 28 mmol/L within
1 week after the procedure (P = .002)
( Gwon et at Radiology 2013)
Complications
Pulmonary complications.
Decrease in PaO2 and A-A gradient ( Arai et
al )
PE ( Sabri et al)
Venous thrombosis
Partial PV or SV thrombosis up to 15% ( Cho
et al)
Partial renal Vein thrombosis ( 7%)
Balloon rupture 8.7% ( Park et al)
Stroke from air embolus( R-L shunt)
TIPS & RTO combination
TIPS may have a protective effect on portal HTN
after RTO ( 5-10% of RTO pts will require TIPS at
some point)
TIPS placement may prevent PV thrombosis post
RTO with diminutive PVs
In Encephalopathic patients, can we replace a
large portosystemic shunt with a small
controllable shunt (TIPS)?
Scenarios
GV with EV or ascites and no encephalopathy:
TIPS +/- GV sclerosis( RTO or antegrade)
GV without EVS or ascites and encephalopathy:
RTO
GV with EV or ascites and encephalopathy:
??TIPS, NBCA , banding and medical management
GV without EVS or ascites and no
encephalopathy: I think RTO