cox · cox cyclooxygenase cyclooxygenase (cox), officially known as prostaglandin-endoperoxide...
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COXCyclooxygenase
Cyclooxygenase (COX) officially known as prostaglandin-endoperoxide synthase (PTGS) is an enzyme that is responsible forformation of important biological mediators called prostanoids including prostaglandins prostacyclin and thromboxanePharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain Drugs like Aspirin that inhibitcyclooxygenase activity have been available to the public for about 100 years Two cyclooxygenase isoforms have been identifiedand are referred to as COX-1 and COX-2 Under many circumstances the COX-1 enzyme is produced constitutively (ie gastricmucosa) whereas COX-2 is inducible (ie sites of inflammation) Non-steroidal anti-inflammatory drugs (NSAID) such as aspirin andibuprofen exert their effects through inhibition of COX The main COX inhibitors are the non-steroidal anti-inflammatory drugs(NSAIDs)
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COX Inhibitors Antagonists amp Activators
(+)-Catechin hydrateCat No HY-N0355
(+)-Catechin hydrate inhibits cyclooxygenase-1( ) with an of 14 μMCOX-1 IC50
Purity 9922Clinical Data Phase 4Size 100 mg
(-)-Catechin ((-)-Cianidanol (-)-Catechuic acid) Cat No HY-N0898A
(-)-Catechin isolated from green tea is anisomer of Catechin having a trans 2S3Rconfiguration at the chiral center Catechininhibits cyclooxygenase-1 (COX-1) with an IC of50
14 μM
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
(-)-Catechin gallate ((-)-Catechin 3-gallate (-)-Catechin 3-O-gallate) Cat No HY-N0356
(-)-Catechin gallate is a minor constituent ingreen tea catechins (-)-Catechin gallate inhibitsthe activity of and enzymesCOX-1 COX-2
Purity 9998Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
(-)-Epicatechin ((-)-Epicatechol Epicatechin epi-Catechin) Cat No HY-N0001
(-)-Epicatechin inhibits cyclooxygenase-1 ( )COX-1with an of 32 μM (-)-Epicatechin inhibitsIC50
the IL-1β-induced expression of iNOS by blockingthe nuclear localization of the p65 subunit ofNF-κB
Purity 9900Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg 100 mg
(-)-Epicatechin gallate (Epicatechin gallate ECG (-)-Epicatechin 3-O-gallate) Cat No HY-N0002
(-)-Epicatechin gallate (Epicatechin gallate)inhibits cyclooxygenase-1 ( ) with an ofCOX-1 IC50
75 μM
Purity 9857Clinical Data Phase 4Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
(E)-Ethyl p-methoxycinnamateCat No HY-N0346A
(E)-Ethyl p-methoxycinnamate is a natural productfound in withKaempferia galangalanti-inflammatory anti-neoplastic andanti-microbial effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
(S)-(+)-Ibuprofen ((S)-Ibuprofen) Cat No HY-78131A
(S)-(+)-Ibuprofen is the S(+)-enantiomer ofIbuprofen that inhibits and activityCOX-1 COX-2with s of 21 μM and 16 μM (S)-(+)-IbuprofenIC50
has analgesic antiinflammatory and antipyreticeffects
Purity 9999Clinical Data No Development ReportedSize 500 mg 1 g 5 g
(S)-(+)-Ibuprofen D3 ((S)-Ibuprofen D3) Cat No HY-78131AS
(S)-(+)-Ibuprofen D3 ((S)-Ibuprofen D3) is adeuterium labeled (S)-(+)-Ibuprofen(S)-(+)-Ibuprofen is the S(+)-enantiomer ofIbuprofen that inhibits and activityCOX-1 COX-2with s of 21 μM and 16 μMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
(S)-Ketorolac ((-)-Ketorolac) Cat No HY-B0580A
(S)-Ketorolac is a nonsteroidal anti-inflammatoryagent (S)-ketorolac exhibits potent andCOX1
enzyme inhibitionCOX2
Purity 9887Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
2-Hydroxy Ibuprofen ((plusmn)-2-Hydroxy Ibuprofen) Cat No HY-126121
2-Hydroxy Ibuprofen is a metabolite of IbuprofenIbuprofen is an anti-inflammatory inhibitortargeting COX-1 and COX-2 with IC s of 13 μM and50
370 μM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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20(S)-Ginsenoside Rg3 (20(S)-Propanaxadiol S-ginsenoside Rg3) Cat No HY-N0603
20(S)-Ginsenoside Rg3 is the main component of Redginseng Ginsenoside Rg3 inhibits andNa+
channel with IC s of 322plusmn45 and 326plusmn22hKv14 50
μM respectively 20(S)-Ginsenoside Rg3 alsoinhibits levels activity and Aβ NF-κB COX-2expression
Purity gt980Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg 100 mg
AceclofenacCat No HY-B0634
Aceclofenac is a non-steroidal anti-inflammatorydrug (NSAID) analog of Diclofenac Target COXAceclofenac is a non-steroidal anti-inflammatorydrug (NSAID) analog of Diclofenac
Purity 9980Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Acemetacin (TVX 1322) Cat No HY-B0482
Acemetacin (TVX 1322) is a non-steroidalanti-inflammatory drug and a glycolic acid esterof indometacin that is a cyclooxygenase inhibitor
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Acetaminophen (Paracetamol 4-Hydroxyacetanilide
4-Acetamidophenol APAP) Cat No HY-66005
Acetaminophen (paracetamol) is a selectivecyclooxygenase-2 ( ) inhibitor with an COX-2 IC50
of 258 μM is a widely used antipyretic andanalgesic drug Acetaminophen is a potent hepatic
inhibitorN-acetyltransferase 2 (NAT2)
Purity 9969Clinical Data LaunchedSize 500 mg 5 g 10 g
AdelmidrolCat No HY-B1026
Adelmidrol exerts important anti-inflammatoryeffects that are partly dependent on PPARγAdelmidrol reduces translocation andNF-κB
expressionCOX-2
Purity gt980Clinical Data Phase 3Size 10 mM times 1 mL 100 mg
Amfenac Sodium HydrateCat No HY-17479A
Amfenac Sodium Hydrate is a inhibitorCOX-2
Purity 9865Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
Ampiroxicam (CP 65703) Cat No HY-17484
Ampiroxicam(CP65703) is a nonselectivecyclooxygenase inhibitor uesd as anti-inflammatorydrug Target COX Ampiroxicam is a non-steroidalanti-inflammatory drug It is a prodrug ofpiroxicam
Purity 9712Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ampyrone (4-Aminoantipyrine) Cat No HY-B1398
Ampyrone is a reagent for glucose determination inthe presence of peroxidase and phenol
Purity 9886Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g
Anemarsaponin BCat No HY-N0811
Anemarsaponin B is a steroidal saponin isolatedfrom the rhizomes of (Liliaceae)A asphodeloidesAnemarsaponin B decreases the protein and mRNAlevels of and iNOS COX-2
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
Asaraldehyde (Asaronaldehyde Asaraldehyde
245-trimethoxy-Benzaldehyde) Cat No HY-100580
Asarylaldehyde is a natural inhibitorCOX-2which isolated from carrot ( L) seedsDaucus carotasignificantly inhibits cyclooxygenase II (COX-2)activity at value 100 μgmLIC50
Purity 9968Clinical Data No Development ReportedSize 100 mg
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Aspirin (Acetylsalicylic Acid ASA) Cat No HY-14654
Aspirin is a non-selective and irreversibleinhibitor of and with s of 5 andCOX-1 COX-2 IC50
210 μgmL
Purity 9990Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
ATB-346Cat No HY-15028
ATB-346 is a novel hydrogen sulphide-releasingderivative of naproxen with markedly reducedtoxicity
Purity 9853Clinical Data Phase 1Size 10 mM times 1 mL 10 mg 50 mg 100 mg
Benzoylgomisin OCat No HY-N2266
Benzoylgomisin O isolated from Schisandra has inhibitory activity againstrubriflora
and enzymes and15-LOX COX-1 COX-2anti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
ByakangelicolCat No HY-N0074
Byakangelicol isolated from Angelica dahuricainhibits interleukin-1beta (IL-1beta) -inducedprostaglandin E2 (PGE2) release in A549 cellsmediated by suppression of cyclooxygenase-2
expression and the activity of COX-2(COX-2)enzyme
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
CafestolCat No HY-N6257
Cafestol one of the major components of coffeeis a coffee-specific diterpene from Cafestol is a
inhibitor for AP-1-targeted activity againstERK production and the mRNA expression ofPGE2
in LPS-activated RAW2647cyclooxygenase (COX)-2cells
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
CarprofenCat No HY-B1227
Carprofen is a nonsteroid anti-inflammatory agentacts as a multi-target inhibitor withFAAHCOX
s of 39 μM 223 μM and 786 μM for COX-2IC50
COX-1 and FAAH respectively
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Catechin ((+)-Catechin Cianidanol Catechuic acid) Cat No HY-N0898
Catechin inhibits cyclooxygenase-1 ( ) withCOX-1an of 14 μMIC50
Purity 9923Clinical Data Phase 4Size 10 mM times 1 mL 10 mg 50 mg 100 mg
Celecoxib (SC 58635) Cat No HY-14398
Celecoxib is a selective inhibitor with anCOX-2 of 40 nMIC50
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 1 g
ColumbinCat No HY-N0389
Columbin is a diterpenoid furanolactone withanti-inflammation activity
Purity 9886Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
COX-2-IN-1Cat No HY-U00275
COX-2-IN-1 is potent and slective inhibitorCOX-2with an of 39 μMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
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COX-2-IN-2Cat No HY-101655
COX-2-IN-2 is a selective and inducible COX2inhibitor with an of 024 μM COX-2-IN-1 isIC50
an anti-inflammatory compound withanti-inflammatory and analgesic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
COX5-LO-IN-1 (Atreleuton analog) Cat No HY-U00347
COX5-LO-IN-1 (Atreleuton analog) is an inhibitorof and usedcylooxygenase 5-lipoxygenase (5-LO)for the research of inflammatory and allergicdisease states
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Crocin IICat No HY-N0698
Crocin II is isolated from the fruit of Gardenia with antioxidant anticancer andjasminoides
antidepressant activity Crocin II inhibits NOproduction with an value of 311 μM CrocinIC50
II suppresses the expressions of protein and m-RNAof and iNOS COX-2
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
DehydrodiisoeugenolCat No HY-N0589
Dehydrodiisoeugenol is isolated from Myristica shows anti-inflammatory andfragrans Houtt
anti-bacterial actions Dehydrodiisoeugenolinhibits LPS- stimulated activation andNF-κBcyclooxygenase ( )-2 gene expression in murineCOXmacrophages
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
DehydroevodiamineCat No HY-N2106
Dehydroevodiamine is a major bioactive quinazolinealkaloid isolated from has anEvodiae Fructusantiarrhythmic effect in guinea-pig ventricularmyocytes
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Deracoxib (SC 046 SC 46 SC 59046) Cat No HY-17509
Deracoxib a selective cyclooxygenase-2 inhibitoris a non-narcotic non-steroidal anti-inflammatorydrug (NSAID)
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Desmethyl CelecoxibCat No HY-118139
Desmethyl Celecoxib (compound 3b) is a selectivecyclooxygenase-2 ( ) inhibitor ( =32 nM)COX-2 IC50
with anti-inflammatory activities DesmethylCelecoxib is an analog of Celecoxib andwith the optimal yield of 75
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
DiclofenacCat No HY-15036
Diclofenac is a potent and nonselectiveanti-inflammatory agent acts as a inhibitorCOXwith s of 4 nM 13 nM for human COX-1 andIC50
COX-2 in CHO cells and 51 084 μM for ovineCOX-1 and COX-2 respectively
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Diclofenac diethylamineCat No HY-15036A
Diclofenac diethylamine is a potent andnonselective anti-inflammatory agent acts as a
inhibitor with s of 4 nM 13 nM forCOX IC50
human COX-1 and COX-2 in CHO cells and 51 084μM for ovine COX-1 and COX-2 respectively
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Diclofenac Sodium (GP 45840) Cat No HY-15037
Diclofenac Sodium (GP 45840) is a potent andnonselective anti-inflammatory agent acts as a
inhibitor with s of 4 nM 13 nM forCOX IC50
human COX-1 and COX-2 in CHO cells and 51 084μM for ovine COX-1 and COX-2 respectively
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g
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Diflunisal (MK-647) Cat No HY-18342
Diflunisal (MK-647) is a salicylate derivativewith nonsteroidal anti-inflammatory and uricosuricproperties which is used alone as an analgesicand in rheumatoid arthritis patients Themechanism of action of diflunisal is as aCyclooxygenase ( ) InhibitorCOX
Purity 9937Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Eicosatetraynoic acid (ETYA) Cat No HY-124108
Eicosatetraynoic acid (ETYA) is a nonspecificinhibitor of and ( =8cyclooxygenase lipoxygenase ID50
μM and 4 μM respectively) Eicosatetraynoic acid(ETYA) activates PPARα and PPARγ chimeras at 10microM
Purity gt98Clinical DataSize 1 mg
Esculentoside ACat No HY-N0632
Esculentoside A (EsA) a kind of triterpenesaponin isolated from roots of Phytolacca esculentaEsculentoside A (EsA) possesses anti-inflammatoryactivity in acute and chronic experimental modelshas selective inhibitory activity towardscyclooxygenase-2 ( )COX-2
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Ethyl CaffeateCat No HY-N6966
Ethyl Caffeate is a natural phenolic compoundisolated from Bidens pilosa
Purity 9891Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Etodolac (AY-24236) Cat No HY-76251
Etodolac (AY-24236) is a non-steroidalanti-inflammatory compound that is a non-selectiveinhibitor of COX (IC =535 nM)50
Purity 9910Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Etoricoxib (MK-0663 L-791456) Cat No HY-15321
Etoricoxib (MK-0663) is a non steroidalanti-inflammatory agent acting as a selective andorally active inhibitor with s of 11COX-2 IC50
μM and 116 μM for COX-2 and COX-1 in human wholeblood
Purity 9992Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Etoricoxib D4 (MK-0663 D4 L-791456 D4) Cat No HY-15321S
Etoricoxib D4 (MK-0663 D4) is a deuterium labeledEtoricoxib Etoricoxib is a non steroidalanti-inflammatory agent acting as a selective andorally active inhibitor with s of 11COX-2 IC50
μM and 116 μM for COX-2 and COX-1 in human wholeblood
Purity 9935Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg
Fenofibric acid (FNF acid) Cat No HY-B0760
Fenofibric acid an active metabolite offenofibrate is a activitor with s ofPPAR EC50
224 microM 147 microM and 106 microM for PPARα PPARγ andPPARδ respectively Fenofibric acid also inhibits
enzyme activity with an of 48 nMCOX-2 IC50
Purity 9938Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Fenoprofen CalciumCat No HY-B0288A
Fenoprofen Calcium is a nonsteroidalanti-inflammatory antiarthritic agent
Purity gt98Clinical Data LaunchedSize 500 mg 1 g 5 g
Fenoprofen Calcium hydrate (Fenoprofen calcium salt dihydrate) Cat No HY-B0288B
Fenoprofen Calcium hydrate is a nonsteroidalanti-inflammatory antiarthritic agent
Purity 9935Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
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Firocoxib (ML 1785713) Cat No HY-14670
Firocoxib(ML 1785713) is a potent and selectivecyclooxygenase (COX)-2 inhibitor with IC50 of 013uM 58 fold sensitivity for COX2 VSCOX1
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
FK 3311 (COX-2 Inhibitor V) Cat No HY-14445
FK 3311 (COX-2 Inhibitor V) is a selectiveinhibitor of with antiinflammatory agentCOX-2
Purity 9806Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
Flosulide (ZK 38997 CGP 28238) Cat No HY-U00083
Flosulide is a potent and selective COX-2inhibitor used for the treatment for inflammatorydiseases
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Flufenamic acidCat No HY-B1221
Flufenamic acid is a non-steroidalanti-inflammatory agent inhibits cyclooxygenase( ) activates and also modulates ionCOX AMPKchannels blocking and chloride channels L-type
modulating non-selective cationCa channels2+
channels ( ) activating NSC K channels+
Purity 9992Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Flunixin meglumineCat No HY-B0386
Flunixin Meglumine is a potent inhibitor of COXused as analgesic agent with anti-inflammatory andantipyretic activity Target COX Flunixinmeglumine is a potent non-narcotic non-steroidalanalgesic agent with anti-inflammatory andantipyretic activity
Purity 9965Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
FR-188582Cat No HY-U00146
FR-188582 is a highly selective inhibitor of ( )-2 with an value of 17cyclooxygenase COX IC50
nM
Purity 9921Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Gallic acid (345-Trihydroxybenzoic acid) Cat No HY-N0523
Gallic acid is an antioxidant which can inhibitboth COX-2
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Ginsenoside C-K (Ginsenoside compound K Ginsenoside K) Cat No HY-N0904
Ginsenoside C-K a bacterial metabolite of G-Rb1exhibits anti-inflammatory effects by reducing iNOSand Ginsenoside C-K exhibits an inhibitionCOX-2against the activity of and inCYP2C9 CYP2A6human liver microsomes with s of 320plusmn36 μMIC50
and 636plusmn42 μM respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ginsenoside Rb3 (Gypenoside IV) Cat No HY-N0041
Ginsenoside Rb3 is extracted from steamed Panax Ginsenoside Rb3 exhibits inhibitorynotoginseng
effect on TNFα-induced transcriptionalNF-κBactivity with an of 82 μM in 293T cellIC50
lines Ginsenoside Rb3 also inhibits the inductionof and mRNACOX-2 iNOS
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ginsenoside Rd (Gypenoside VIII) Cat No HY-N0043
Ginsenoside Rd inhibits TNFα-induced NF-κBtranscriptional activity with an ofIC50
1205plusmn082 μM in HepG2 cells Ginsenoside Rdinhibits expression of and mRNACOX-2 iNOSGinsenoside Rd also inhibits influxCa2+
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
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Ginsenoside Rg5Cat No HY-N0908
Ginsenoside Rg5 is the main component of Redginseng Ginsenoside blocks binding of to itsIGF-1receptor with an of ~90 nM Ginsenoside Rg5IC50
also inhibits the mRNA expression of viaCOX-2suppression of the DNA binding activities of
NF-κB p65
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
GnetolCat No HY-126052
Gnetol is a phenolic compound isolated from theroot of Brongn Gnetol potentlyGnetum ulainhibits ( of 078 μM) and COX-1 IC50 HDACGnetol is a potent inhibitor with antyrosinase
of 45 μM for murine tyrosinase andIC50
suppresses melanin biosynthesis
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Guaiacol (2-Methoxyphenol) Cat No HY-N1380
Guaiacol a phenolic compound isolated from Guaiacresin inhibits LPS-stimulated expressionCOX-2and activation Anti-inflammatory activityNF-κB
Purity 9929Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
GW-406381Cat No HY-119304
GW406381 a highly selective cyclooxygenase-2 inhibitor attenuates spontaneous ectopic(COX-2)
discharge in sural nerves of rats followingchronic constriction injury
Purity 9959Clinical DataSize 10 mM times 1 mL 1 mg
HamaudolCat No HY-N6891
Hamaudol is a chromone isolated from Saposhnikovia Hamaudol shows significant inhibitorydivaricata
activity on and cyclooxygenase (COX)-1 COX-2activities with values of 030 057 mMIC50
respectively and has potent analgesia andanti-inflammary effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
HarpagosideCat No HY-N0396
Harpagoside is isolated from Harpagophytum Harpagoside has inhibitory effectsprocumbens (Hp)
on and activity and inhibits NOCOX-1 COX-2production
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
HexahydrocurcuminCat No HY-N0929
Hexahydrocurcumin is a natural compound whichposesses anticancer and anti-inflammatoryactivities selective COX-2 inhibitor
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Ibuprofen ((plusmn)-Ibuprofen) Cat No HY-78131
Ibuprofen is an anti-inflammatory inhibitortargeting and with s of 13 μMCOX-1 COX-2 IC50
and 370 μM respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Ibuprofen D3 ((plusmn)-Ibuprofen D3) Cat No HY-78131S
Ibuprofen D3 is a deuterium labeled IbuprofenIbuprofen is a COX-1 and COX-2 inhibitor with IC s50
of 13 μM and 370 μM
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Iguratimod (T614) Cat No HY-17009
Iguratimod is an antirheumatic agent acts as aninhibitor of with an of 20 μM (77COX-2 IC50
μgmL) but shows no effect on COX-1 Iguratimodalso inhibits macrophage migration inhibitoryfactor ( ) with an of 681 μMMIF IC50
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
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Imrecoxib (BAP-909) Cat No HY-114200
Imrecoxib (BAP-909) is a novel and selectivecyclooxygenase 2 ( ) inhibitor with an COX-2 IC50
value of 18 nM it also inhibits COX1- activitywith an value of 115 nM Imrecoxib (BAP-909)IC50
has anti-inflammatory effect
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 50 mg 100 mg
Indobufen (Ibustrin) Cat No HY-18763
Indobufen is a platelet aggregation inhibitorIndobufen is a reversible platelet cyclooxygenase( ) activity inhibitor Indobufen suppressesCoxthromboxane A (TxA ) synthesis Indobufen2 2
down-regulates tissue factor (TF) in monocytes
Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Indomethacin (Indometacin) Cat No HY-14397
Indomethacin is a potent and nonselectiveinhibitor of and with s of 18 nMCOX1 COX2 IC50
and 26 nM for human COX-1 and COX-2 respectivelyin CHO cells
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Inulicin (1-O-Acetylbritannilactone) Cat No HY-N0896
Inulicin (1-O-Acetylbritannilactone) is an activecompound isolated from InulicinInula Britannica L(1-O-Acetylbritannilactone) inhibits VEGF-mediatedactivation of and Src FAK
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Isoorientin (Homoorientin) Cat No HY-N0767
Isoorientin is a potent inhibitor of withCOX-2an value of 39 μMIC50
Purity 9924Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 25 mg 50 mg
JaceosidinCat No HY-N0831
Jaceosidin is a flavonoid isolated from induces apoptosis in cancerArtemisia vestita
cells activates and down-regulates Mcl-1 andBaxc-FLIP expression
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 25 mg
Ketoprofen (RP-19583) Cat No HY-B0227
Ketoprofen (RP-19583) is a non-steroidalantiinflammatory agent acting as a potentinhibitor of with s of 2 nM and 26 nMCOX IC50
for COX-1 and COX-2 in human blood monocytesrespectively
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Ketorolac (RS37619) Cat No HY-B0580
Ketorolac is a non-steroidal anti-inflammatoryagent acting as a nonselective inhibitorCOXwith s of 20 nM for COX-1 and 120 nM forIC50
COX-2
Purity gt98Clinical Data LaunchedSize 100 mg 500 mg
Ketorolac D5Cat No HY-B0580S
Ketorolac D5 is a deuterium labeled KetorolacKetorolac is a non-steroidal anti-inflammatoryagent acting as a nonselective inhibitorCOXwith s of 20 nM for COX-1 and 120 nM forIC50
COX-2
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ketorolac tromethamine salt (Ketorolac Tromethamine
Ketorolac tris salt RS37619 tromethamine salt) Cat No HY-B0138
Ketorolac tromethamine salt (RS37619 tromethaminesalt) is a non-steroidal anti-inflammatory agentacting as a nonselective inhibitor withCOX
s of 20 nM for COX-1 and 120 nM for COX-2IC50
Purity 9994Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
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Licofelone (ML-3000) Cat No HY-B1452
Licofelone (ML-3000) is a dual COX5-lipoxygenase inhibitor ( =021018 μM(5-LOX) IC50
respectively) for the treatment of osteoarthritisLicofelone exerts anti-inflammatory andanti-proliferative effects
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
Lornoxicam (Chlortenoxicam Ro 13-9297 TS110) Cat No HY-B0367
Lornoxicam a COX-1 and COX-2 inhibitor is a newnonsteroidal anti-inflammatory drug (NSAID)Target COX Lornoxicam showed a balancedinhibition of COX-1-2 exhibiting the lowest IC50(0005 microM0008 microM) of the large panel ofNSAIDs tested
Purity 9831Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
LoxoprofenCat No HY-B0578
Loxoprofen is a non-steroidal anti-inflammatorydrug Target COX Loxoprofen is a non-steroidalanti-inflammatory drug in the propionic acidderivatives group which also includes ibuprofenand naproxen among others
Purity 9882Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
LY 178002Cat No HY-101579
LY 178002 is a potent inhibitor of 5-lipoxygenase with of 06 μM(5-LPO) phospholipase A2 IC50
for 5-lipoxygenase inhibits cellular productionof LTB4 by human polymorphonuclear leukocytes andshows relatively weak inhibition on cyclooxygenase
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
MavacoxibCat No HY-119447
Mavacoxib is a selective oral long-acting inhibitor and acyclooxygenase-2 (COX-2)
long-acting non-steroidal anti-inflammatory drug(NSAID) Mavacoxib is used to treat pain andinflammation associated with degenerative jointdisease in dogs
Purity 9983Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Mefenamic acidCat No HY-B0574
Mefenamic acid is a non-steroidalanti-inflammatory agent acting as a competitiveinhibitor of and with s of 40hCOX-1 hCOX-2 IC50
nM and 3 μM for hCOX-1 and hCOX-2 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
MeloxicamCat No HY-B0261
Meloxicam is a non-steroidal antiinflammatoryagent inhibits activity with s of 049COX IC50
microM and 366 microM for COX-2 and COX-1 respectively
Purity 9807Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Meloxicam D4Cat No HY-B0261S
Meloxicam D4 is deuterium labeled MeloxicamMeloxicam is a non-steroidal antiinflammatoryagent inhibits COX activity with IC s of 049 microM50
and 366 microM for COX-2 and COX-1 respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Metamizole sodium hydrateCat No HY-B1279
Metamizole sodium hydrate is a potent analgesicdrug that has been demonstrated to inhibitcyclooxygenase (COX)
Purity gt980Clinical Data LaunchedSize 500 mg
Methyl Salicylate (Wintergreen oil) Cat No HY-Y0189
Methyl Salicylate (Wintergreen oil) is a topicalanalgesic and anti-inflammatory agent Also usedas a pesticide a denaturant a fragranceingredient and a flavoring agent in food andtobacco products A systemic acquired resistance(SAR) signal in tobacco
Purity 9998Clinical Data No Development ReportedSize 10 mM times 1 mL 50 mg
10 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
N-trans-Feruloyltyramine (N-feruloyltyramine Moupinamide) Cat No HY-N2410
N-trans-Feruloyltyramine (N-feruloyltyramine) analkaloid from is an inhibitor of Piper nigru COX1and with potential antioxidant propertiesCOX2N-trans-Feruloyltyramine possessesanti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
Nabumetone (BRL14777) Cat No HY-B0559
Nabumetone is an orally active non-acidicanti-inflammatory agent acts as a potent andselective inhibitor and is the prodrug ofCOX-2the active metabolite 6MNA
Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Naproxen ((S)-Naproxen) Cat No HY-15030
Naproxen is a and inhibitor withCOX-1 COX-2s of 872 and 515 μM respectively in cellIC50
assay
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Naproxen etemesil (LT-NS 001 MX 1094) Cat No HY-19675
Naproxen etemesil is a lipophilic non-acidicinactive prodrug of naproxen that is hydrolysed topharmacologically active Naproxen once absorbedNaproxen is a and inhibitor withCOX-1 COX-2
s of 872 and 515 μM respectively in cellIC50
assay
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Naproxen sodiumCat No HY-15030A
Naproxen sodium is a and inhibitorCOX-1 COX-2with s of 872 and 515 μM respectively inIC50
cell assay
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) Cat No HY-N0722
Neochlorogenic acid is a natural polyphenoliccompound found in dried fruits and other plantsNeochlorogenic acid inhibits the production of
and Neochlorogenic acid suppressesTNF-α IL-1β protein expressioniNOS and COX-2
Purity 9946Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Nepafenac (AHR 9434 AL 6515) Cat No HY-17357
Nepafenac(AHR 9434 AL 6515 Nevanac) is aselective COX-2 inhibitor is prodrug of AmfenacIC50 value Target COX-2 Nepafenac is a NSAID(nonsteroidal anti inflammatory drug) that isroutinely used in opthamology to control painfollowing cataract surgery
Purity 9514Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Nepafenac D5 (AHR-9434 D5 AL-6515 D5) Cat No HY-17357S
Nepafenac D5 is the deuterium labeled Nepafenacwhich is a selective COX-2 inhibitor
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Nimesulide (R805) Cat No HY-B0363
Nimesulide is a selective inhibitor withCOX-2s of 70 nM-70 μM in a time-dependent mannerIC50
but it shows no effect on COX-1 (IC gt100 μM)50
Nimesulide has potent anti-inflammatory analgesicand antipyretic properties
Purity 9991Clinical Data Phase 4Size 10 mM times 1 mL 100 mg 500 mg
Nimesulide D5Cat No HY-B0363S
Nimesulide D5 is a deuterium labeled NimesulideNimesulide is a selective inhibitor withCOX-2
s of 70 nM-70 μM in a time-dependent mannerIC50
but it shows no effect on COX-1 (IC gt100 μM)50
Nimesulide has potent anti-inflammatory analgesicand antipyretic properties
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 11
Nitroaspirin (NCX 4016) Cat No HY-123823
Nitroaspirin (NCX 4016) is a nitric oxide (NO)donor and a nitro-derivative of Aspirin whichcombines with Nitroaspirin to inhibitcyclooxygenase
Purity gt98Clinical DataSize 1 mg 5 mg
Nitroflurbiprofen (HCT 1206 NO-flurbiprofen Nitroxybutyl flurbiprofen) Cat No HY-U00013
Nitroflurbiprofen is a ( )cyclooxygenase COXinhibitor with nitric oxide (NO)-donatingproperties modulates the increased intrahepaticvascular tone in portal hypertensive cirrhoticrats
Purity 9964Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
NS-398Cat No HY-13913
NS-398 is a non-steroidal an-inflammatory agentwith analgesic and antipyretic effects andselectively inhibits prostaglandin GH synthase2cyclooxygenase 2 ( ) activity with an COX-2 IC50
of 38 μM and has no effect on COX-1 at 100 μM
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Oxaprozin (Oxaprozinum Wy21743) Cat No HY-B0808
Oxaprozin is an inhibitor of both andCOX-1 with s of 22 μM and 36 μM for humanCOX-2 IC50
platelet COX-1 and IL-1-stimulated human synovialcell COX-2 respectively Oxaprozin also inhibitsthe activation of NF-κB
Purity 9963Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Oxaprozin D4 (Wy-21743 D4) Cat No HY-B0808S
Oxaprozin D4 is the deuterium labeled Oxaprozinwhich is a non-steroidal anti-inflammatory drug(NSAID)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
Pamicogrel (KBT3022) Cat No HY-U00175
Pamicogrel (KBT3022) is a ( )cyclooxygenase COXinhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Paradol ([6]-Gingerone [6]-Paradol) Cat No HY-14617
Paradol is a pungent phenolic substance found inginger and other Zingiberaceae plants Paradol isan effective inhibitor of tumor promotion in mouseskin carcinogenesis binds to cyclooxygenase
active site(COX)-2
Purity 9988Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Parecoxib (SC 69124) Cat No HY-17474
Parecoxib is a potent and selective COX-2inhibitor IC50 value Target COX-2 in vitro Theprodrug Parecoxib as well as its active metaboliteval have a specific affinity to the cannabinoid(CB) receptor measured in CB1-expressing HEK 293cells and rat brain tissue
Purity 9932Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Parecoxib Sodium (SC 69124A) Cat No HY-17474A
Parecoxib Sodium (SC 69124A) is a potent andselective COX-2 inhibitor
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
PelubiprofenCat No HY-12383
Pelubiprofen an orally active and non-steroidalanti-inflammatory drug is a member of the2-arylpropionic acid family and has relativelyselective effects on activityCOX-2
Purity gt98Clinical Data No Development ReportedSize 100 mg 250 mg 500 mg
12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Phenacetin (Acetophenetidin) Cat No HY-B0476
Phenacetin is a non-opioid analgesic withoutanti-inflammatory properties inhibits COX-3activity Target COX Phenacetin is apain-relieving and fever-reducing drug Phenacetinwas withdrawn from the Canadian market in June1973 due to concerns regarding nephropathy
Purity 9909Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
PhenylbutazoneCat No HY-B0230
Phenylbutazone is used as a non-steroidalanti-inflammatory agent for the treatment ofchronic pain including the symptoms of arthritisTarget Others Phenylbutazone was originally madeavailable for use in humans for the treatment ofrheumatoid arthritis and gout in 1949
Purity 9886Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg
Piroxicam (CP-16171) Cat No HY-B0253
Piroxicam (CP-16171) is a non-steroidalanti-inflammatory drugs acts as a inhibitorCOXwith s of 47 25 μM for human monocyte COX-1IC50
and COX-2 respectively
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g 10 g
Piroxicam D3 (CP-16171 D3) Cat No HY-B0253S
Piroxicam D3 (CP-16171 D3) is deuterium labeledPiroxicam Piroxicam is a non-steroidalanti-inflammatory drugs acts as a COX inhibitorwith IC s of 47 25 μM for human monocyte COX-150
and COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Prim-O-glucosylcimifuginCat No HY-N0635
Prim-O-glucosylcimifugin exerts anti-inflammatoryeffects through the inhibition of and iNOS COX-2expression by through regulating JAK2STAT3signaling
Purity 9976Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Propyphenazone (4-Isopropylantipyrine Isopropylphenazone) Cat No HY-A0273
Propyphenazone is a pyrazolone derivative withanti-inflammatory analgesic and antipyreticactivity Propyphenazone-based analogues asprodrugs and selective cyclooxygenase-2inhibitors
Purity 9994Clinical Data LaunchedSize 10 mM times 1 mL 250 mg
PsoralidinCat No HY-N0232
Psoralidin isolated from the seed of Psoralea is a dual inhibitor of andcorylifolia COX-2
regulates ionizing radiation (IR)-induced5-LOXpulmonary inflammationAnti-canceranti-bacterial and anti-inflammatory properties
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg
Rebamipide (OPC12759 Proamipide) Cat No HY-B0360
Rebamipide (OPC12759) is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Rebamipide D4 (OPC12759 D4 Proamipide D4) Cat No HY-B0360S
Rebamipide D4 (OPC12759 D4) is deuterium labeledRebamipide Rebamipide is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Revaprazan hydrochlorideCat No HY-N7067
Revaprazan hydrochloride is a novel acid pumpantagonist ( ) Revaprazan hydrochlorideAPAreduces expression and has significantCOX-2anti-inflammatory actions activities in H pyloriinfection
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 13
RHC 80267 (U-57908) Cat No HY-107416
RHC 80267 (U-57908) is a potent and selectiveinhibitor of (withdiacylglycerol lipase (DAGL)
of 4 μM in canine platelets) RHC-80267IC50
inhibits activity with an of 4cholinesterase IC50
μM thereby enhancing the relaxation evoked byacetylcholine
Purity gt98Clinical Data No Development ReportedSize 10 mM1m 10 mg 25 mg 50 mg 100 mg
Roburic acidCat No HY-N0481
Roburic acid a tetracyclic triterpenoid found in acts as an inhibitor ofGentiana macrophylla
with s of 5 and 9 μM for COX-1 andCOX IC50
COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Rofecoxib (MK 966) Cat No HY-17372
Rofecoxib is a potent specific and orally active inhibitor with s of 26 and 18 nM forCOX-2 IC50
human COX-2 in human osteosarcoma cells andChinese hamster ovary cells with a 1000-foldselectivity for COX-2 over human COX-1 (IC gt50
50 μM in U937 cells and gt 15 μM inhellip
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Rutaecarpine (Rutecarpine) Cat No HY-N0147
Rutaecarpine an alkaloid of isEvodia rutaecarpaan inhibitor of with an value of 028COX-2 IC50
μM
Purity 9911Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
RWJ 63556Cat No HY-U00022
RWJ 63556 is an orally active COX-2 inhibitor withselective5-lipoxygenase
anti-inflammatory activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
S-(+)-Ketoprofen ((S)-Ketoprofen Dexketoprofen) Cat No HY-B2137
S-(+)-Ketoprofen is a potent inhibitor of both and with s of 19 and 27 nMCOX-1 COX-2 IC50
respectively
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
S-(+)-Marmesin ((+)-Marmesin (S)-Marmesin) Cat No HY-N2176
S-(+)-Marmesin is a natural coumarin exhibiting dual inhibitory activityCOX-25-LOX
Purity 9904Clinical Data No Development ReportedSize 2 mg 5 mg 10 mg 25 mg 50 mg
S-2474Cat No HY-19212
S-2474 is an inhibitor of and COX-2 5-lipoxygenase with s of 11 nM and 27 μM for COX-2(5-LO) IC50
and COX-1 in human intact cells and used as anonsteroidal anti-inflammatory drug
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Salicin (D-(minus)-Salicin Salicoside) Cat No HY-N0149
Salicin is a natural inhibitorCOX
Purity 9960Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
Salicylic acid (2-Hydroxybenzoic acid) Cat No HY-B0167
Salicylic acid inhibits cyclo-oxygenase-2 ( )COX-2activity independently of transcription factor(NF-κB) activation
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
14 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SC-560Cat No HY-59105
SC-560 is a potent and selective inhibitorCOX-1with an of 9 nMIC50
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SC57666Cat No HY-U00129
SC57666 is a selective inhibitor with anCOX2 of 26 nMIC50
Purity 9894Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 20 mg
SC58451Cat No HY-U00239
SC58451 is a potent and selective Cox-2inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Sodium Salicylate (Salicylic acid sodium salt
2-Hydroxybenzoic acid sodium salt) Cat No HY-B0167A
Sodium Salicylate inhibits cyclo-oxygenase-2( ) activity independently of transcriptionCOX-2factor (NF-κB) activation
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
Sulindac (MK-231) Cat No HY-B0008
Sulindac (MK-231) is a non-steroidalantiinflammatory agent acts as a COX-2inhibitor and inhibits overexpression of COX-2
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
SyringaldehydeCat No HY-N1390
Syringaldehyde is a polyphenolic compoundbelonging to the group of flavonoids and is foundin different plant species like Manihot
and esculenta Magnolia officinalisSyringaldehyde moderately inhibits activityCOX-2with an of 35 μgmLIC50
Purity 9996Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Tenidap (CP-66248) Cat No HY-105028
Tenidap a non-steroidal anti-inflammatory drugis a selective inhibitor with valuesCOX-1 IC50
of 003 microM and 12 microM for COX-1 and COX-2respectively Tenidap has anti-inflammatory andantirheumatic properties Tenidap is also aspecific SLC26A3 inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tenoxicam (Ro-12-0068) Cat No HY-B0440
Tenoxicam (Ro-12-0068) an antiinflammatory agentwith analgesic and antipyretic properties
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) Cat No HY-112731
TFAP is a selective cyclooxygenase-1 (COX-1)inhibitor with an of 08 μMIC50
Purity 9997Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Thioflosulide (L-745337) Cat No HY-19217
Thioflosulide (L-745337) is a selective inhibitor with an ofcyclooxygenase-2 (COX2) IC50
23 nM and shows anti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
wwwMedChemExpresscom 15
Tilmacoxib (JTE522 JTP19605 RWJ57504) Cat No HY-U00197
Tilmacoxib (JTE522) is a highly selectivetime-dependent and irreversible human COX-2inhibitor with an of 85 nM in an enzymeIC50
assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Timegadine (SR1368) Cat No HY-100125
Timegadine a new antiinflammatory agent is foundto be a potent competitive inhibitor of
( ) and withcyclo-oxygenase COX lipo-oxygenases ranging from 5 nM (washed rabbit platelets)IC50
to 20 μM (rat brain) for COX and 100 μM forlipo-oxygenase both in the cytosol fractionhellip
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tolfenamic Acid (GEA 6414) Cat No HY-B0335
Tolfenamic Acid (GEA 6414) is a non-steroidalanti-inflammatory and anti-cancer agentselectively inhibits with an of 1349COX-2 IC50
μM (353 μgmL) in LPS-treated (COX-2) canine DH82monocytemacrophage cells but shows no effect onCOX-1
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 10 g
Tolmetin sodium dihydrateCat No HY-B1489
Tolmetin sodium dihydrate is a non-steroidalantiinflammatory agent and acts as anon-selective inhibitorCOX
Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
TriflusalCat No HY-B0531
Triflusal irreversibly inhibits the production ofthromboxane-B2 in platelets by acetylatingcycloxygenase-1 Target COX Triflusal at 10 mM100 mM and 1 M decreases LDH efflux in rat brainslices after anoxiareoxygenation by 24 35 and49 respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Valdecoxib (SC 65872) Cat No HY-15762
Valdecoxib is a highly potent and selectiveinhibitor of with s of 5 nM and 140 μMCOX-2 IC50
for COX-2 and COX-1 respeceively Valdecoxib canbe used in the research of arthritis and pain
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Veratric acid (34-Dimethoxybenzoic acid) Cat No HY-N2007
Veratric acid (34-Dimethoxybenzoic acid) is anorally active phenolic compound derived fromvegetables and fruits has antioxidant andanti-inflammatory activities
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
XanthohumolCat No HY-N1067
Xanthohumol is one of the principal flavonoidsisolated from hops the inhibitor ofdiacylglycerol acetyltransferase ( ) DGAT COX-1and COX-2 and shows anti-cancer andanti-angiogenic activities
Purity 9968Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 25 mg
Zaltoprofen (CN100) Cat No HY-B0619
Zaltoprofen(CN100) is an inhibitor of COX fortreatment of arthritis
Purity 9909Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
[10]-ShogaolCat No HY-N2434
[10]-Shogaol is an antioxidant from Zingiber for human skin cell growth and aofficinale
migration enhancer [10]-Shogaol inhibits COX-2with an of 75 μM and has antiproliferationIC50
activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
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[8]-ShogaolCat No HY-N2435
-Shogaol one of the pungent phenolic compounds inginger exhibits anti-platelet activity ( =5IC50
μM) and inhibits COX-2 ( =175 μM) -ShogaolIC50
induces apoptosis in human leukemia cells
Purity 9918Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-Humulene (Humulene α-Caryophyllene) Cat No HY-N6968
α-Humulene is a main constituent of Tanacetum L (Asteraceae) essential oil withvulgare
anti-inflammation (IC =15plusmn2 microgmL) α-Humulene50
inhibits and expressionCOX-2 iNOS
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-ChaconineCat No HY-129113
α-Chaconine isolated from a Solanum L cv Jayoung inhibits thetuberosum
expressions of and atCOX-2 IL-1β IL-6 TNF-αthe transcriptional level
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 17
COX Inhibitors Antagonists amp Activators
(+)-Catechin hydrateCat No HY-N0355
(+)-Catechin hydrate inhibits cyclooxygenase-1( ) with an of 14 μMCOX-1 IC50
Purity 9922Clinical Data Phase 4Size 100 mg
(-)-Catechin ((-)-Cianidanol (-)-Catechuic acid) Cat No HY-N0898A
(-)-Catechin isolated from green tea is anisomer of Catechin having a trans 2S3Rconfiguration at the chiral center Catechininhibits cyclooxygenase-1 (COX-1) with an IC of50
14 μM
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
(-)-Catechin gallate ((-)-Catechin 3-gallate (-)-Catechin 3-O-gallate) Cat No HY-N0356
(-)-Catechin gallate is a minor constituent ingreen tea catechins (-)-Catechin gallate inhibitsthe activity of and enzymesCOX-1 COX-2
Purity 9998Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
(-)-Epicatechin ((-)-Epicatechol Epicatechin epi-Catechin) Cat No HY-N0001
(-)-Epicatechin inhibits cyclooxygenase-1 ( )COX-1with an of 32 μM (-)-Epicatechin inhibitsIC50
the IL-1β-induced expression of iNOS by blockingthe nuclear localization of the p65 subunit ofNF-κB
Purity 9900Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg 100 mg
(-)-Epicatechin gallate (Epicatechin gallate ECG (-)-Epicatechin 3-O-gallate) Cat No HY-N0002
(-)-Epicatechin gallate (Epicatechin gallate)inhibits cyclooxygenase-1 ( ) with an ofCOX-1 IC50
75 μM
Purity 9857Clinical Data Phase 4Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
(E)-Ethyl p-methoxycinnamateCat No HY-N0346A
(E)-Ethyl p-methoxycinnamate is a natural productfound in withKaempferia galangalanti-inflammatory anti-neoplastic andanti-microbial effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
(S)-(+)-Ibuprofen ((S)-Ibuprofen) Cat No HY-78131A
(S)-(+)-Ibuprofen is the S(+)-enantiomer ofIbuprofen that inhibits and activityCOX-1 COX-2with s of 21 μM and 16 μM (S)-(+)-IbuprofenIC50
has analgesic antiinflammatory and antipyreticeffects
Purity 9999Clinical Data No Development ReportedSize 500 mg 1 g 5 g
(S)-(+)-Ibuprofen D3 ((S)-Ibuprofen D3) Cat No HY-78131AS
(S)-(+)-Ibuprofen D3 ((S)-Ibuprofen D3) is adeuterium labeled (S)-(+)-Ibuprofen(S)-(+)-Ibuprofen is the S(+)-enantiomer ofIbuprofen that inhibits and activityCOX-1 COX-2with s of 21 μM and 16 μMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
(S)-Ketorolac ((-)-Ketorolac) Cat No HY-B0580A
(S)-Ketorolac is a nonsteroidal anti-inflammatoryagent (S)-ketorolac exhibits potent andCOX1
enzyme inhibitionCOX2
Purity 9887Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
2-Hydroxy Ibuprofen ((plusmn)-2-Hydroxy Ibuprofen) Cat No HY-126121
2-Hydroxy Ibuprofen is a metabolite of IbuprofenIbuprofen is an anti-inflammatory inhibitortargeting COX-1 and COX-2 with IC s of 13 μM and50
370 μM respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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20(S)-Ginsenoside Rg3 (20(S)-Propanaxadiol S-ginsenoside Rg3) Cat No HY-N0603
20(S)-Ginsenoside Rg3 is the main component of Redginseng Ginsenoside Rg3 inhibits andNa+
channel with IC s of 322plusmn45 and 326plusmn22hKv14 50
μM respectively 20(S)-Ginsenoside Rg3 alsoinhibits levels activity and Aβ NF-κB COX-2expression
Purity gt980Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg 100 mg
AceclofenacCat No HY-B0634
Aceclofenac is a non-steroidal anti-inflammatorydrug (NSAID) analog of Diclofenac Target COXAceclofenac is a non-steroidal anti-inflammatorydrug (NSAID) analog of Diclofenac
Purity 9980Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Acemetacin (TVX 1322) Cat No HY-B0482
Acemetacin (TVX 1322) is a non-steroidalanti-inflammatory drug and a glycolic acid esterof indometacin that is a cyclooxygenase inhibitor
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Acetaminophen (Paracetamol 4-Hydroxyacetanilide
4-Acetamidophenol APAP) Cat No HY-66005
Acetaminophen (paracetamol) is a selectivecyclooxygenase-2 ( ) inhibitor with an COX-2 IC50
of 258 μM is a widely used antipyretic andanalgesic drug Acetaminophen is a potent hepatic
inhibitorN-acetyltransferase 2 (NAT2)
Purity 9969Clinical Data LaunchedSize 500 mg 5 g 10 g
AdelmidrolCat No HY-B1026
Adelmidrol exerts important anti-inflammatoryeffects that are partly dependent on PPARγAdelmidrol reduces translocation andNF-κB
expressionCOX-2
Purity gt980Clinical Data Phase 3Size 10 mM times 1 mL 100 mg
Amfenac Sodium HydrateCat No HY-17479A
Amfenac Sodium Hydrate is a inhibitorCOX-2
Purity 9865Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
Ampiroxicam (CP 65703) Cat No HY-17484
Ampiroxicam(CP65703) is a nonselectivecyclooxygenase inhibitor uesd as anti-inflammatorydrug Target COX Ampiroxicam is a non-steroidalanti-inflammatory drug It is a prodrug ofpiroxicam
Purity 9712Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ampyrone (4-Aminoantipyrine) Cat No HY-B1398
Ampyrone is a reagent for glucose determination inthe presence of peroxidase and phenol
Purity 9886Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g
Anemarsaponin BCat No HY-N0811
Anemarsaponin B is a steroidal saponin isolatedfrom the rhizomes of (Liliaceae)A asphodeloidesAnemarsaponin B decreases the protein and mRNAlevels of and iNOS COX-2
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
Asaraldehyde (Asaronaldehyde Asaraldehyde
245-trimethoxy-Benzaldehyde) Cat No HY-100580
Asarylaldehyde is a natural inhibitorCOX-2which isolated from carrot ( L) seedsDaucus carotasignificantly inhibits cyclooxygenase II (COX-2)activity at value 100 μgmLIC50
Purity 9968Clinical Data No Development ReportedSize 100 mg
wwwMedChemExpresscom 3
Aspirin (Acetylsalicylic Acid ASA) Cat No HY-14654
Aspirin is a non-selective and irreversibleinhibitor of and with s of 5 andCOX-1 COX-2 IC50
210 μgmL
Purity 9990Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
ATB-346Cat No HY-15028
ATB-346 is a novel hydrogen sulphide-releasingderivative of naproxen with markedly reducedtoxicity
Purity 9853Clinical Data Phase 1Size 10 mM times 1 mL 10 mg 50 mg 100 mg
Benzoylgomisin OCat No HY-N2266
Benzoylgomisin O isolated from Schisandra has inhibitory activity againstrubriflora
and enzymes and15-LOX COX-1 COX-2anti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
ByakangelicolCat No HY-N0074
Byakangelicol isolated from Angelica dahuricainhibits interleukin-1beta (IL-1beta) -inducedprostaglandin E2 (PGE2) release in A549 cellsmediated by suppression of cyclooxygenase-2
expression and the activity of COX-2(COX-2)enzyme
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
CafestolCat No HY-N6257
Cafestol one of the major components of coffeeis a coffee-specific diterpene from Cafestol is a
inhibitor for AP-1-targeted activity againstERK production and the mRNA expression ofPGE2
in LPS-activated RAW2647cyclooxygenase (COX)-2cells
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
CarprofenCat No HY-B1227
Carprofen is a nonsteroid anti-inflammatory agentacts as a multi-target inhibitor withFAAHCOX
s of 39 μM 223 μM and 786 μM for COX-2IC50
COX-1 and FAAH respectively
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Catechin ((+)-Catechin Cianidanol Catechuic acid) Cat No HY-N0898
Catechin inhibits cyclooxygenase-1 ( ) withCOX-1an of 14 μMIC50
Purity 9923Clinical Data Phase 4Size 10 mM times 1 mL 10 mg 50 mg 100 mg
Celecoxib (SC 58635) Cat No HY-14398
Celecoxib is a selective inhibitor with anCOX-2 of 40 nMIC50
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 1 g
ColumbinCat No HY-N0389
Columbin is a diterpenoid furanolactone withanti-inflammation activity
Purity 9886Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
COX-2-IN-1Cat No HY-U00275
COX-2-IN-1 is potent and slective inhibitorCOX-2with an of 39 μMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
4 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
COX-2-IN-2Cat No HY-101655
COX-2-IN-2 is a selective and inducible COX2inhibitor with an of 024 μM COX-2-IN-1 isIC50
an anti-inflammatory compound withanti-inflammatory and analgesic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
COX5-LO-IN-1 (Atreleuton analog) Cat No HY-U00347
COX5-LO-IN-1 (Atreleuton analog) is an inhibitorof and usedcylooxygenase 5-lipoxygenase (5-LO)for the research of inflammatory and allergicdisease states
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Crocin IICat No HY-N0698
Crocin II is isolated from the fruit of Gardenia with antioxidant anticancer andjasminoides
antidepressant activity Crocin II inhibits NOproduction with an value of 311 μM CrocinIC50
II suppresses the expressions of protein and m-RNAof and iNOS COX-2
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
DehydrodiisoeugenolCat No HY-N0589
Dehydrodiisoeugenol is isolated from Myristica shows anti-inflammatory andfragrans Houtt
anti-bacterial actions Dehydrodiisoeugenolinhibits LPS- stimulated activation andNF-κBcyclooxygenase ( )-2 gene expression in murineCOXmacrophages
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
DehydroevodiamineCat No HY-N2106
Dehydroevodiamine is a major bioactive quinazolinealkaloid isolated from has anEvodiae Fructusantiarrhythmic effect in guinea-pig ventricularmyocytes
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Deracoxib (SC 046 SC 46 SC 59046) Cat No HY-17509
Deracoxib a selective cyclooxygenase-2 inhibitoris a non-narcotic non-steroidal anti-inflammatorydrug (NSAID)
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Desmethyl CelecoxibCat No HY-118139
Desmethyl Celecoxib (compound 3b) is a selectivecyclooxygenase-2 ( ) inhibitor ( =32 nM)COX-2 IC50
with anti-inflammatory activities DesmethylCelecoxib is an analog of Celecoxib andwith the optimal yield of 75
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
DiclofenacCat No HY-15036
Diclofenac is a potent and nonselectiveanti-inflammatory agent acts as a inhibitorCOXwith s of 4 nM 13 nM for human COX-1 andIC50
COX-2 in CHO cells and 51 084 μM for ovineCOX-1 and COX-2 respectively
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Diclofenac diethylamineCat No HY-15036A
Diclofenac diethylamine is a potent andnonselective anti-inflammatory agent acts as a
inhibitor with s of 4 nM 13 nM forCOX IC50
human COX-1 and COX-2 in CHO cells and 51 084μM for ovine COX-1 and COX-2 respectively
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Diclofenac Sodium (GP 45840) Cat No HY-15037
Diclofenac Sodium (GP 45840) is a potent andnonselective anti-inflammatory agent acts as a
inhibitor with s of 4 nM 13 nM forCOX IC50
human COX-1 and COX-2 in CHO cells and 51 084μM for ovine COX-1 and COX-2 respectively
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g
wwwMedChemExpresscom 5
Diflunisal (MK-647) Cat No HY-18342
Diflunisal (MK-647) is a salicylate derivativewith nonsteroidal anti-inflammatory and uricosuricproperties which is used alone as an analgesicand in rheumatoid arthritis patients Themechanism of action of diflunisal is as aCyclooxygenase ( ) InhibitorCOX
Purity 9937Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Eicosatetraynoic acid (ETYA) Cat No HY-124108
Eicosatetraynoic acid (ETYA) is a nonspecificinhibitor of and ( =8cyclooxygenase lipoxygenase ID50
μM and 4 μM respectively) Eicosatetraynoic acid(ETYA) activates PPARα and PPARγ chimeras at 10microM
Purity gt98Clinical DataSize 1 mg
Esculentoside ACat No HY-N0632
Esculentoside A (EsA) a kind of triterpenesaponin isolated from roots of Phytolacca esculentaEsculentoside A (EsA) possesses anti-inflammatoryactivity in acute and chronic experimental modelshas selective inhibitory activity towardscyclooxygenase-2 ( )COX-2
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Ethyl CaffeateCat No HY-N6966
Ethyl Caffeate is a natural phenolic compoundisolated from Bidens pilosa
Purity 9891Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Etodolac (AY-24236) Cat No HY-76251
Etodolac (AY-24236) is a non-steroidalanti-inflammatory compound that is a non-selectiveinhibitor of COX (IC =535 nM)50
Purity 9910Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Etoricoxib (MK-0663 L-791456) Cat No HY-15321
Etoricoxib (MK-0663) is a non steroidalanti-inflammatory agent acting as a selective andorally active inhibitor with s of 11COX-2 IC50
μM and 116 μM for COX-2 and COX-1 in human wholeblood
Purity 9992Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Etoricoxib D4 (MK-0663 D4 L-791456 D4) Cat No HY-15321S
Etoricoxib D4 (MK-0663 D4) is a deuterium labeledEtoricoxib Etoricoxib is a non steroidalanti-inflammatory agent acting as a selective andorally active inhibitor with s of 11COX-2 IC50
μM and 116 μM for COX-2 and COX-1 in human wholeblood
Purity 9935Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg
Fenofibric acid (FNF acid) Cat No HY-B0760
Fenofibric acid an active metabolite offenofibrate is a activitor with s ofPPAR EC50
224 microM 147 microM and 106 microM for PPARα PPARγ andPPARδ respectively Fenofibric acid also inhibits
enzyme activity with an of 48 nMCOX-2 IC50
Purity 9938Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Fenoprofen CalciumCat No HY-B0288A
Fenoprofen Calcium is a nonsteroidalanti-inflammatory antiarthritic agent
Purity gt98Clinical Data LaunchedSize 500 mg 1 g 5 g
Fenoprofen Calcium hydrate (Fenoprofen calcium salt dihydrate) Cat No HY-B0288B
Fenoprofen Calcium hydrate is a nonsteroidalanti-inflammatory antiarthritic agent
Purity 9935Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
6 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Firocoxib (ML 1785713) Cat No HY-14670
Firocoxib(ML 1785713) is a potent and selectivecyclooxygenase (COX)-2 inhibitor with IC50 of 013uM 58 fold sensitivity for COX2 VSCOX1
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
FK 3311 (COX-2 Inhibitor V) Cat No HY-14445
FK 3311 (COX-2 Inhibitor V) is a selectiveinhibitor of with antiinflammatory agentCOX-2
Purity 9806Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
Flosulide (ZK 38997 CGP 28238) Cat No HY-U00083
Flosulide is a potent and selective COX-2inhibitor used for the treatment for inflammatorydiseases
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Flufenamic acidCat No HY-B1221
Flufenamic acid is a non-steroidalanti-inflammatory agent inhibits cyclooxygenase( ) activates and also modulates ionCOX AMPKchannels blocking and chloride channels L-type
modulating non-selective cationCa channels2+
channels ( ) activating NSC K channels+
Purity 9992Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Flunixin meglumineCat No HY-B0386
Flunixin Meglumine is a potent inhibitor of COXused as analgesic agent with anti-inflammatory andantipyretic activity Target COX Flunixinmeglumine is a potent non-narcotic non-steroidalanalgesic agent with anti-inflammatory andantipyretic activity
Purity 9965Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
FR-188582Cat No HY-U00146
FR-188582 is a highly selective inhibitor of ( )-2 with an value of 17cyclooxygenase COX IC50
nM
Purity 9921Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Gallic acid (345-Trihydroxybenzoic acid) Cat No HY-N0523
Gallic acid is an antioxidant which can inhibitboth COX-2
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Ginsenoside C-K (Ginsenoside compound K Ginsenoside K) Cat No HY-N0904
Ginsenoside C-K a bacterial metabolite of G-Rb1exhibits anti-inflammatory effects by reducing iNOSand Ginsenoside C-K exhibits an inhibitionCOX-2against the activity of and inCYP2C9 CYP2A6human liver microsomes with s of 320plusmn36 μMIC50
and 636plusmn42 μM respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ginsenoside Rb3 (Gypenoside IV) Cat No HY-N0041
Ginsenoside Rb3 is extracted from steamed Panax Ginsenoside Rb3 exhibits inhibitorynotoginseng
effect on TNFα-induced transcriptionalNF-κBactivity with an of 82 μM in 293T cellIC50
lines Ginsenoside Rb3 also inhibits the inductionof and mRNACOX-2 iNOS
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ginsenoside Rd (Gypenoside VIII) Cat No HY-N0043
Ginsenoside Rd inhibits TNFα-induced NF-κBtranscriptional activity with an ofIC50
1205plusmn082 μM in HepG2 cells Ginsenoside Rdinhibits expression of and mRNACOX-2 iNOSGinsenoside Rd also inhibits influxCa2+
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
wwwMedChemExpresscom 7
Ginsenoside Rg5Cat No HY-N0908
Ginsenoside Rg5 is the main component of Redginseng Ginsenoside blocks binding of to itsIGF-1receptor with an of ~90 nM Ginsenoside Rg5IC50
also inhibits the mRNA expression of viaCOX-2suppression of the DNA binding activities of
NF-κB p65
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
GnetolCat No HY-126052
Gnetol is a phenolic compound isolated from theroot of Brongn Gnetol potentlyGnetum ulainhibits ( of 078 μM) and COX-1 IC50 HDACGnetol is a potent inhibitor with antyrosinase
of 45 μM for murine tyrosinase andIC50
suppresses melanin biosynthesis
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Guaiacol (2-Methoxyphenol) Cat No HY-N1380
Guaiacol a phenolic compound isolated from Guaiacresin inhibits LPS-stimulated expressionCOX-2and activation Anti-inflammatory activityNF-κB
Purity 9929Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
GW-406381Cat No HY-119304
GW406381 a highly selective cyclooxygenase-2 inhibitor attenuates spontaneous ectopic(COX-2)
discharge in sural nerves of rats followingchronic constriction injury
Purity 9959Clinical DataSize 10 mM times 1 mL 1 mg
HamaudolCat No HY-N6891
Hamaudol is a chromone isolated from Saposhnikovia Hamaudol shows significant inhibitorydivaricata
activity on and cyclooxygenase (COX)-1 COX-2activities with values of 030 057 mMIC50
respectively and has potent analgesia andanti-inflammary effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
HarpagosideCat No HY-N0396
Harpagoside is isolated from Harpagophytum Harpagoside has inhibitory effectsprocumbens (Hp)
on and activity and inhibits NOCOX-1 COX-2production
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
HexahydrocurcuminCat No HY-N0929
Hexahydrocurcumin is a natural compound whichposesses anticancer and anti-inflammatoryactivities selective COX-2 inhibitor
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Ibuprofen ((plusmn)-Ibuprofen) Cat No HY-78131
Ibuprofen is an anti-inflammatory inhibitortargeting and with s of 13 μMCOX-1 COX-2 IC50
and 370 μM respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Ibuprofen D3 ((plusmn)-Ibuprofen D3) Cat No HY-78131S
Ibuprofen D3 is a deuterium labeled IbuprofenIbuprofen is a COX-1 and COX-2 inhibitor with IC s50
of 13 μM and 370 μM
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Iguratimod (T614) Cat No HY-17009
Iguratimod is an antirheumatic agent acts as aninhibitor of with an of 20 μM (77COX-2 IC50
μgmL) but shows no effect on COX-1 Iguratimodalso inhibits macrophage migration inhibitoryfactor ( ) with an of 681 μMMIF IC50
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
8 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Imrecoxib (BAP-909) Cat No HY-114200
Imrecoxib (BAP-909) is a novel and selectivecyclooxygenase 2 ( ) inhibitor with an COX-2 IC50
value of 18 nM it also inhibits COX1- activitywith an value of 115 nM Imrecoxib (BAP-909)IC50
has anti-inflammatory effect
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 50 mg 100 mg
Indobufen (Ibustrin) Cat No HY-18763
Indobufen is a platelet aggregation inhibitorIndobufen is a reversible platelet cyclooxygenase( ) activity inhibitor Indobufen suppressesCoxthromboxane A (TxA ) synthesis Indobufen2 2
down-regulates tissue factor (TF) in monocytes
Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Indomethacin (Indometacin) Cat No HY-14397
Indomethacin is a potent and nonselectiveinhibitor of and with s of 18 nMCOX1 COX2 IC50
and 26 nM for human COX-1 and COX-2 respectivelyin CHO cells
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Inulicin (1-O-Acetylbritannilactone) Cat No HY-N0896
Inulicin (1-O-Acetylbritannilactone) is an activecompound isolated from InulicinInula Britannica L(1-O-Acetylbritannilactone) inhibits VEGF-mediatedactivation of and Src FAK
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Isoorientin (Homoorientin) Cat No HY-N0767
Isoorientin is a potent inhibitor of withCOX-2an value of 39 μMIC50
Purity 9924Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 25 mg 50 mg
JaceosidinCat No HY-N0831
Jaceosidin is a flavonoid isolated from induces apoptosis in cancerArtemisia vestita
cells activates and down-regulates Mcl-1 andBaxc-FLIP expression
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 25 mg
Ketoprofen (RP-19583) Cat No HY-B0227
Ketoprofen (RP-19583) is a non-steroidalantiinflammatory agent acting as a potentinhibitor of with s of 2 nM and 26 nMCOX IC50
for COX-1 and COX-2 in human blood monocytesrespectively
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Ketorolac (RS37619) Cat No HY-B0580
Ketorolac is a non-steroidal anti-inflammatoryagent acting as a nonselective inhibitorCOXwith s of 20 nM for COX-1 and 120 nM forIC50
COX-2
Purity gt98Clinical Data LaunchedSize 100 mg 500 mg
Ketorolac D5Cat No HY-B0580S
Ketorolac D5 is a deuterium labeled KetorolacKetorolac is a non-steroidal anti-inflammatoryagent acting as a nonselective inhibitorCOXwith s of 20 nM for COX-1 and 120 nM forIC50
COX-2
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ketorolac tromethamine salt (Ketorolac Tromethamine
Ketorolac tris salt RS37619 tromethamine salt) Cat No HY-B0138
Ketorolac tromethamine salt (RS37619 tromethaminesalt) is a non-steroidal anti-inflammatory agentacting as a nonselective inhibitor withCOX
s of 20 nM for COX-1 and 120 nM for COX-2IC50
Purity 9994Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
wwwMedChemExpresscom 9
Licofelone (ML-3000) Cat No HY-B1452
Licofelone (ML-3000) is a dual COX5-lipoxygenase inhibitor ( =021018 μM(5-LOX) IC50
respectively) for the treatment of osteoarthritisLicofelone exerts anti-inflammatory andanti-proliferative effects
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
Lornoxicam (Chlortenoxicam Ro 13-9297 TS110) Cat No HY-B0367
Lornoxicam a COX-1 and COX-2 inhibitor is a newnonsteroidal anti-inflammatory drug (NSAID)Target COX Lornoxicam showed a balancedinhibition of COX-1-2 exhibiting the lowest IC50(0005 microM0008 microM) of the large panel ofNSAIDs tested
Purity 9831Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
LoxoprofenCat No HY-B0578
Loxoprofen is a non-steroidal anti-inflammatorydrug Target COX Loxoprofen is a non-steroidalanti-inflammatory drug in the propionic acidderivatives group which also includes ibuprofenand naproxen among others
Purity 9882Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
LY 178002Cat No HY-101579
LY 178002 is a potent inhibitor of 5-lipoxygenase with of 06 μM(5-LPO) phospholipase A2 IC50
for 5-lipoxygenase inhibits cellular productionof LTB4 by human polymorphonuclear leukocytes andshows relatively weak inhibition on cyclooxygenase
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
MavacoxibCat No HY-119447
Mavacoxib is a selective oral long-acting inhibitor and acyclooxygenase-2 (COX-2)
long-acting non-steroidal anti-inflammatory drug(NSAID) Mavacoxib is used to treat pain andinflammation associated with degenerative jointdisease in dogs
Purity 9983Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Mefenamic acidCat No HY-B0574
Mefenamic acid is a non-steroidalanti-inflammatory agent acting as a competitiveinhibitor of and with s of 40hCOX-1 hCOX-2 IC50
nM and 3 μM for hCOX-1 and hCOX-2 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
MeloxicamCat No HY-B0261
Meloxicam is a non-steroidal antiinflammatoryagent inhibits activity with s of 049COX IC50
microM and 366 microM for COX-2 and COX-1 respectively
Purity 9807Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Meloxicam D4Cat No HY-B0261S
Meloxicam D4 is deuterium labeled MeloxicamMeloxicam is a non-steroidal antiinflammatoryagent inhibits COX activity with IC s of 049 microM50
and 366 microM for COX-2 and COX-1 respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Metamizole sodium hydrateCat No HY-B1279
Metamizole sodium hydrate is a potent analgesicdrug that has been demonstrated to inhibitcyclooxygenase (COX)
Purity gt980Clinical Data LaunchedSize 500 mg
Methyl Salicylate (Wintergreen oil) Cat No HY-Y0189
Methyl Salicylate (Wintergreen oil) is a topicalanalgesic and anti-inflammatory agent Also usedas a pesticide a denaturant a fragranceingredient and a flavoring agent in food andtobacco products A systemic acquired resistance(SAR) signal in tobacco
Purity 9998Clinical Data No Development ReportedSize 10 mM times 1 mL 50 mg
10 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
N-trans-Feruloyltyramine (N-feruloyltyramine Moupinamide) Cat No HY-N2410
N-trans-Feruloyltyramine (N-feruloyltyramine) analkaloid from is an inhibitor of Piper nigru COX1and with potential antioxidant propertiesCOX2N-trans-Feruloyltyramine possessesanti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
Nabumetone (BRL14777) Cat No HY-B0559
Nabumetone is an orally active non-acidicanti-inflammatory agent acts as a potent andselective inhibitor and is the prodrug ofCOX-2the active metabolite 6MNA
Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Naproxen ((S)-Naproxen) Cat No HY-15030
Naproxen is a and inhibitor withCOX-1 COX-2s of 872 and 515 μM respectively in cellIC50
assay
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Naproxen etemesil (LT-NS 001 MX 1094) Cat No HY-19675
Naproxen etemesil is a lipophilic non-acidicinactive prodrug of naproxen that is hydrolysed topharmacologically active Naproxen once absorbedNaproxen is a and inhibitor withCOX-1 COX-2
s of 872 and 515 μM respectively in cellIC50
assay
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Naproxen sodiumCat No HY-15030A
Naproxen sodium is a and inhibitorCOX-1 COX-2with s of 872 and 515 μM respectively inIC50
cell assay
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) Cat No HY-N0722
Neochlorogenic acid is a natural polyphenoliccompound found in dried fruits and other plantsNeochlorogenic acid inhibits the production of
and Neochlorogenic acid suppressesTNF-α IL-1β protein expressioniNOS and COX-2
Purity 9946Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Nepafenac (AHR 9434 AL 6515) Cat No HY-17357
Nepafenac(AHR 9434 AL 6515 Nevanac) is aselective COX-2 inhibitor is prodrug of AmfenacIC50 value Target COX-2 Nepafenac is a NSAID(nonsteroidal anti inflammatory drug) that isroutinely used in opthamology to control painfollowing cataract surgery
Purity 9514Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Nepafenac D5 (AHR-9434 D5 AL-6515 D5) Cat No HY-17357S
Nepafenac D5 is the deuterium labeled Nepafenacwhich is a selective COX-2 inhibitor
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Nimesulide (R805) Cat No HY-B0363
Nimesulide is a selective inhibitor withCOX-2s of 70 nM-70 μM in a time-dependent mannerIC50
but it shows no effect on COX-1 (IC gt100 μM)50
Nimesulide has potent anti-inflammatory analgesicand antipyretic properties
Purity 9991Clinical Data Phase 4Size 10 mM times 1 mL 100 mg 500 mg
Nimesulide D5Cat No HY-B0363S
Nimesulide D5 is a deuterium labeled NimesulideNimesulide is a selective inhibitor withCOX-2
s of 70 nM-70 μM in a time-dependent mannerIC50
but it shows no effect on COX-1 (IC gt100 μM)50
Nimesulide has potent anti-inflammatory analgesicand antipyretic properties
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 11
Nitroaspirin (NCX 4016) Cat No HY-123823
Nitroaspirin (NCX 4016) is a nitric oxide (NO)donor and a nitro-derivative of Aspirin whichcombines with Nitroaspirin to inhibitcyclooxygenase
Purity gt98Clinical DataSize 1 mg 5 mg
Nitroflurbiprofen (HCT 1206 NO-flurbiprofen Nitroxybutyl flurbiprofen) Cat No HY-U00013
Nitroflurbiprofen is a ( )cyclooxygenase COXinhibitor with nitric oxide (NO)-donatingproperties modulates the increased intrahepaticvascular tone in portal hypertensive cirrhoticrats
Purity 9964Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
NS-398Cat No HY-13913
NS-398 is a non-steroidal an-inflammatory agentwith analgesic and antipyretic effects andselectively inhibits prostaglandin GH synthase2cyclooxygenase 2 ( ) activity with an COX-2 IC50
of 38 μM and has no effect on COX-1 at 100 μM
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Oxaprozin (Oxaprozinum Wy21743) Cat No HY-B0808
Oxaprozin is an inhibitor of both andCOX-1 with s of 22 μM and 36 μM for humanCOX-2 IC50
platelet COX-1 and IL-1-stimulated human synovialcell COX-2 respectively Oxaprozin also inhibitsthe activation of NF-κB
Purity 9963Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Oxaprozin D4 (Wy-21743 D4) Cat No HY-B0808S
Oxaprozin D4 is the deuterium labeled Oxaprozinwhich is a non-steroidal anti-inflammatory drug(NSAID)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
Pamicogrel (KBT3022) Cat No HY-U00175
Pamicogrel (KBT3022) is a ( )cyclooxygenase COXinhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Paradol ([6]-Gingerone [6]-Paradol) Cat No HY-14617
Paradol is a pungent phenolic substance found inginger and other Zingiberaceae plants Paradol isan effective inhibitor of tumor promotion in mouseskin carcinogenesis binds to cyclooxygenase
active site(COX)-2
Purity 9988Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Parecoxib (SC 69124) Cat No HY-17474
Parecoxib is a potent and selective COX-2inhibitor IC50 value Target COX-2 in vitro Theprodrug Parecoxib as well as its active metaboliteval have a specific affinity to the cannabinoid(CB) receptor measured in CB1-expressing HEK 293cells and rat brain tissue
Purity 9932Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Parecoxib Sodium (SC 69124A) Cat No HY-17474A
Parecoxib Sodium (SC 69124A) is a potent andselective COX-2 inhibitor
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
PelubiprofenCat No HY-12383
Pelubiprofen an orally active and non-steroidalanti-inflammatory drug is a member of the2-arylpropionic acid family and has relativelyselective effects on activityCOX-2
Purity gt98Clinical Data No Development ReportedSize 100 mg 250 mg 500 mg
12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Phenacetin (Acetophenetidin) Cat No HY-B0476
Phenacetin is a non-opioid analgesic withoutanti-inflammatory properties inhibits COX-3activity Target COX Phenacetin is apain-relieving and fever-reducing drug Phenacetinwas withdrawn from the Canadian market in June1973 due to concerns regarding nephropathy
Purity 9909Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
PhenylbutazoneCat No HY-B0230
Phenylbutazone is used as a non-steroidalanti-inflammatory agent for the treatment ofchronic pain including the symptoms of arthritisTarget Others Phenylbutazone was originally madeavailable for use in humans for the treatment ofrheumatoid arthritis and gout in 1949
Purity 9886Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg
Piroxicam (CP-16171) Cat No HY-B0253
Piroxicam (CP-16171) is a non-steroidalanti-inflammatory drugs acts as a inhibitorCOXwith s of 47 25 μM for human monocyte COX-1IC50
and COX-2 respectively
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g 10 g
Piroxicam D3 (CP-16171 D3) Cat No HY-B0253S
Piroxicam D3 (CP-16171 D3) is deuterium labeledPiroxicam Piroxicam is a non-steroidalanti-inflammatory drugs acts as a COX inhibitorwith IC s of 47 25 μM for human monocyte COX-150
and COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Prim-O-glucosylcimifuginCat No HY-N0635
Prim-O-glucosylcimifugin exerts anti-inflammatoryeffects through the inhibition of and iNOS COX-2expression by through regulating JAK2STAT3signaling
Purity 9976Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Propyphenazone (4-Isopropylantipyrine Isopropylphenazone) Cat No HY-A0273
Propyphenazone is a pyrazolone derivative withanti-inflammatory analgesic and antipyreticactivity Propyphenazone-based analogues asprodrugs and selective cyclooxygenase-2inhibitors
Purity 9994Clinical Data LaunchedSize 10 mM times 1 mL 250 mg
PsoralidinCat No HY-N0232
Psoralidin isolated from the seed of Psoralea is a dual inhibitor of andcorylifolia COX-2
regulates ionizing radiation (IR)-induced5-LOXpulmonary inflammationAnti-canceranti-bacterial and anti-inflammatory properties
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg
Rebamipide (OPC12759 Proamipide) Cat No HY-B0360
Rebamipide (OPC12759) is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Rebamipide D4 (OPC12759 D4 Proamipide D4) Cat No HY-B0360S
Rebamipide D4 (OPC12759 D4) is deuterium labeledRebamipide Rebamipide is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Revaprazan hydrochlorideCat No HY-N7067
Revaprazan hydrochloride is a novel acid pumpantagonist ( ) Revaprazan hydrochlorideAPAreduces expression and has significantCOX-2anti-inflammatory actions activities in H pyloriinfection
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 13
RHC 80267 (U-57908) Cat No HY-107416
RHC 80267 (U-57908) is a potent and selectiveinhibitor of (withdiacylglycerol lipase (DAGL)
of 4 μM in canine platelets) RHC-80267IC50
inhibits activity with an of 4cholinesterase IC50
μM thereby enhancing the relaxation evoked byacetylcholine
Purity gt98Clinical Data No Development ReportedSize 10 mM1m 10 mg 25 mg 50 mg 100 mg
Roburic acidCat No HY-N0481
Roburic acid a tetracyclic triterpenoid found in acts as an inhibitor ofGentiana macrophylla
with s of 5 and 9 μM for COX-1 andCOX IC50
COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Rofecoxib (MK 966) Cat No HY-17372
Rofecoxib is a potent specific and orally active inhibitor with s of 26 and 18 nM forCOX-2 IC50
human COX-2 in human osteosarcoma cells andChinese hamster ovary cells with a 1000-foldselectivity for COX-2 over human COX-1 (IC gt50
50 μM in U937 cells and gt 15 μM inhellip
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Rutaecarpine (Rutecarpine) Cat No HY-N0147
Rutaecarpine an alkaloid of isEvodia rutaecarpaan inhibitor of with an value of 028COX-2 IC50
μM
Purity 9911Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
RWJ 63556Cat No HY-U00022
RWJ 63556 is an orally active COX-2 inhibitor withselective5-lipoxygenase
anti-inflammatory activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
S-(+)-Ketoprofen ((S)-Ketoprofen Dexketoprofen) Cat No HY-B2137
S-(+)-Ketoprofen is a potent inhibitor of both and with s of 19 and 27 nMCOX-1 COX-2 IC50
respectively
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
S-(+)-Marmesin ((+)-Marmesin (S)-Marmesin) Cat No HY-N2176
S-(+)-Marmesin is a natural coumarin exhibiting dual inhibitory activityCOX-25-LOX
Purity 9904Clinical Data No Development ReportedSize 2 mg 5 mg 10 mg 25 mg 50 mg
S-2474Cat No HY-19212
S-2474 is an inhibitor of and COX-2 5-lipoxygenase with s of 11 nM and 27 μM for COX-2(5-LO) IC50
and COX-1 in human intact cells and used as anonsteroidal anti-inflammatory drug
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Salicin (D-(minus)-Salicin Salicoside) Cat No HY-N0149
Salicin is a natural inhibitorCOX
Purity 9960Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
Salicylic acid (2-Hydroxybenzoic acid) Cat No HY-B0167
Salicylic acid inhibits cyclo-oxygenase-2 ( )COX-2activity independently of transcription factor(NF-κB) activation
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
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SC-560Cat No HY-59105
SC-560 is a potent and selective inhibitorCOX-1with an of 9 nMIC50
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SC57666Cat No HY-U00129
SC57666 is a selective inhibitor with anCOX2 of 26 nMIC50
Purity 9894Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 20 mg
SC58451Cat No HY-U00239
SC58451 is a potent and selective Cox-2inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Sodium Salicylate (Salicylic acid sodium salt
2-Hydroxybenzoic acid sodium salt) Cat No HY-B0167A
Sodium Salicylate inhibits cyclo-oxygenase-2( ) activity independently of transcriptionCOX-2factor (NF-κB) activation
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
Sulindac (MK-231) Cat No HY-B0008
Sulindac (MK-231) is a non-steroidalantiinflammatory agent acts as a COX-2inhibitor and inhibits overexpression of COX-2
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
SyringaldehydeCat No HY-N1390
Syringaldehyde is a polyphenolic compoundbelonging to the group of flavonoids and is foundin different plant species like Manihot
and esculenta Magnolia officinalisSyringaldehyde moderately inhibits activityCOX-2with an of 35 μgmLIC50
Purity 9996Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Tenidap (CP-66248) Cat No HY-105028
Tenidap a non-steroidal anti-inflammatory drugis a selective inhibitor with valuesCOX-1 IC50
of 003 microM and 12 microM for COX-1 and COX-2respectively Tenidap has anti-inflammatory andantirheumatic properties Tenidap is also aspecific SLC26A3 inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tenoxicam (Ro-12-0068) Cat No HY-B0440
Tenoxicam (Ro-12-0068) an antiinflammatory agentwith analgesic and antipyretic properties
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) Cat No HY-112731
TFAP is a selective cyclooxygenase-1 (COX-1)inhibitor with an of 08 μMIC50
Purity 9997Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Thioflosulide (L-745337) Cat No HY-19217
Thioflosulide (L-745337) is a selective inhibitor with an ofcyclooxygenase-2 (COX2) IC50
23 nM and shows anti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
wwwMedChemExpresscom 15
Tilmacoxib (JTE522 JTP19605 RWJ57504) Cat No HY-U00197
Tilmacoxib (JTE522) is a highly selectivetime-dependent and irreversible human COX-2inhibitor with an of 85 nM in an enzymeIC50
assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Timegadine (SR1368) Cat No HY-100125
Timegadine a new antiinflammatory agent is foundto be a potent competitive inhibitor of
( ) and withcyclo-oxygenase COX lipo-oxygenases ranging from 5 nM (washed rabbit platelets)IC50
to 20 μM (rat brain) for COX and 100 μM forlipo-oxygenase both in the cytosol fractionhellip
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tolfenamic Acid (GEA 6414) Cat No HY-B0335
Tolfenamic Acid (GEA 6414) is a non-steroidalanti-inflammatory and anti-cancer agentselectively inhibits with an of 1349COX-2 IC50
μM (353 μgmL) in LPS-treated (COX-2) canine DH82monocytemacrophage cells but shows no effect onCOX-1
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 10 g
Tolmetin sodium dihydrateCat No HY-B1489
Tolmetin sodium dihydrate is a non-steroidalantiinflammatory agent and acts as anon-selective inhibitorCOX
Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
TriflusalCat No HY-B0531
Triflusal irreversibly inhibits the production ofthromboxane-B2 in platelets by acetylatingcycloxygenase-1 Target COX Triflusal at 10 mM100 mM and 1 M decreases LDH efflux in rat brainslices after anoxiareoxygenation by 24 35 and49 respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Valdecoxib (SC 65872) Cat No HY-15762
Valdecoxib is a highly potent and selectiveinhibitor of with s of 5 nM and 140 μMCOX-2 IC50
for COX-2 and COX-1 respeceively Valdecoxib canbe used in the research of arthritis and pain
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Veratric acid (34-Dimethoxybenzoic acid) Cat No HY-N2007
Veratric acid (34-Dimethoxybenzoic acid) is anorally active phenolic compound derived fromvegetables and fruits has antioxidant andanti-inflammatory activities
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
XanthohumolCat No HY-N1067
Xanthohumol is one of the principal flavonoidsisolated from hops the inhibitor ofdiacylglycerol acetyltransferase ( ) DGAT COX-1and COX-2 and shows anti-cancer andanti-angiogenic activities
Purity 9968Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 25 mg
Zaltoprofen (CN100) Cat No HY-B0619
Zaltoprofen(CN100) is an inhibitor of COX fortreatment of arthritis
Purity 9909Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
[10]-ShogaolCat No HY-N2434
[10]-Shogaol is an antioxidant from Zingiber for human skin cell growth and aofficinale
migration enhancer [10]-Shogaol inhibits COX-2with an of 75 μM and has antiproliferationIC50
activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
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[8]-ShogaolCat No HY-N2435
-Shogaol one of the pungent phenolic compounds inginger exhibits anti-platelet activity ( =5IC50
μM) and inhibits COX-2 ( =175 μM) -ShogaolIC50
induces apoptosis in human leukemia cells
Purity 9918Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-Humulene (Humulene α-Caryophyllene) Cat No HY-N6968
α-Humulene is a main constituent of Tanacetum L (Asteraceae) essential oil withvulgare
anti-inflammation (IC =15plusmn2 microgmL) α-Humulene50
inhibits and expressionCOX-2 iNOS
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-ChaconineCat No HY-129113
α-Chaconine isolated from a Solanum L cv Jayoung inhibits thetuberosum
expressions of and atCOX-2 IL-1β IL-6 TNF-αthe transcriptional level
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 17
20(S)-Ginsenoside Rg3 (20(S)-Propanaxadiol S-ginsenoside Rg3) Cat No HY-N0603
20(S)-Ginsenoside Rg3 is the main component of Redginseng Ginsenoside Rg3 inhibits andNa+
channel with IC s of 322plusmn45 and 326plusmn22hKv14 50
μM respectively 20(S)-Ginsenoside Rg3 alsoinhibits levels activity and Aβ NF-κB COX-2expression
Purity gt980Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg 100 mg
AceclofenacCat No HY-B0634
Aceclofenac is a non-steroidal anti-inflammatorydrug (NSAID) analog of Diclofenac Target COXAceclofenac is a non-steroidal anti-inflammatorydrug (NSAID) analog of Diclofenac
Purity 9980Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Acemetacin (TVX 1322) Cat No HY-B0482
Acemetacin (TVX 1322) is a non-steroidalanti-inflammatory drug and a glycolic acid esterof indometacin that is a cyclooxygenase inhibitor
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Acetaminophen (Paracetamol 4-Hydroxyacetanilide
4-Acetamidophenol APAP) Cat No HY-66005
Acetaminophen (paracetamol) is a selectivecyclooxygenase-2 ( ) inhibitor with an COX-2 IC50
of 258 μM is a widely used antipyretic andanalgesic drug Acetaminophen is a potent hepatic
inhibitorN-acetyltransferase 2 (NAT2)
Purity 9969Clinical Data LaunchedSize 500 mg 5 g 10 g
AdelmidrolCat No HY-B1026
Adelmidrol exerts important anti-inflammatoryeffects that are partly dependent on PPARγAdelmidrol reduces translocation andNF-κB
expressionCOX-2
Purity gt980Clinical Data Phase 3Size 10 mM times 1 mL 100 mg
Amfenac Sodium HydrateCat No HY-17479A
Amfenac Sodium Hydrate is a inhibitorCOX-2
Purity 9865Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
Ampiroxicam (CP 65703) Cat No HY-17484
Ampiroxicam(CP65703) is a nonselectivecyclooxygenase inhibitor uesd as anti-inflammatorydrug Target COX Ampiroxicam is a non-steroidalanti-inflammatory drug It is a prodrug ofpiroxicam
Purity 9712Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Ampyrone (4-Aminoantipyrine) Cat No HY-B1398
Ampyrone is a reagent for glucose determination inthe presence of peroxidase and phenol
Purity 9886Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g
Anemarsaponin BCat No HY-N0811
Anemarsaponin B is a steroidal saponin isolatedfrom the rhizomes of (Liliaceae)A asphodeloidesAnemarsaponin B decreases the protein and mRNAlevels of and iNOS COX-2
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
Asaraldehyde (Asaronaldehyde Asaraldehyde
245-trimethoxy-Benzaldehyde) Cat No HY-100580
Asarylaldehyde is a natural inhibitorCOX-2which isolated from carrot ( L) seedsDaucus carotasignificantly inhibits cyclooxygenase II (COX-2)activity at value 100 μgmLIC50
Purity 9968Clinical Data No Development ReportedSize 100 mg
wwwMedChemExpresscom 3
Aspirin (Acetylsalicylic Acid ASA) Cat No HY-14654
Aspirin is a non-selective and irreversibleinhibitor of and with s of 5 andCOX-1 COX-2 IC50
210 μgmL
Purity 9990Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
ATB-346Cat No HY-15028
ATB-346 is a novel hydrogen sulphide-releasingderivative of naproxen with markedly reducedtoxicity
Purity 9853Clinical Data Phase 1Size 10 mM times 1 mL 10 mg 50 mg 100 mg
Benzoylgomisin OCat No HY-N2266
Benzoylgomisin O isolated from Schisandra has inhibitory activity againstrubriflora
and enzymes and15-LOX COX-1 COX-2anti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
ByakangelicolCat No HY-N0074
Byakangelicol isolated from Angelica dahuricainhibits interleukin-1beta (IL-1beta) -inducedprostaglandin E2 (PGE2) release in A549 cellsmediated by suppression of cyclooxygenase-2
expression and the activity of COX-2(COX-2)enzyme
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
CafestolCat No HY-N6257
Cafestol one of the major components of coffeeis a coffee-specific diterpene from Cafestol is a
inhibitor for AP-1-targeted activity againstERK production and the mRNA expression ofPGE2
in LPS-activated RAW2647cyclooxygenase (COX)-2cells
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
CarprofenCat No HY-B1227
Carprofen is a nonsteroid anti-inflammatory agentacts as a multi-target inhibitor withFAAHCOX
s of 39 μM 223 μM and 786 μM for COX-2IC50
COX-1 and FAAH respectively
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Catechin ((+)-Catechin Cianidanol Catechuic acid) Cat No HY-N0898
Catechin inhibits cyclooxygenase-1 ( ) withCOX-1an of 14 μMIC50
Purity 9923Clinical Data Phase 4Size 10 mM times 1 mL 10 mg 50 mg 100 mg
Celecoxib (SC 58635) Cat No HY-14398
Celecoxib is a selective inhibitor with anCOX-2 of 40 nMIC50
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 1 g
ColumbinCat No HY-N0389
Columbin is a diterpenoid furanolactone withanti-inflammation activity
Purity 9886Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
COX-2-IN-1Cat No HY-U00275
COX-2-IN-1 is potent and slective inhibitorCOX-2with an of 39 μMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
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COX-2-IN-2Cat No HY-101655
COX-2-IN-2 is a selective and inducible COX2inhibitor with an of 024 μM COX-2-IN-1 isIC50
an anti-inflammatory compound withanti-inflammatory and analgesic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
COX5-LO-IN-1 (Atreleuton analog) Cat No HY-U00347
COX5-LO-IN-1 (Atreleuton analog) is an inhibitorof and usedcylooxygenase 5-lipoxygenase (5-LO)for the research of inflammatory and allergicdisease states
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Crocin IICat No HY-N0698
Crocin II is isolated from the fruit of Gardenia with antioxidant anticancer andjasminoides
antidepressant activity Crocin II inhibits NOproduction with an value of 311 μM CrocinIC50
II suppresses the expressions of protein and m-RNAof and iNOS COX-2
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
DehydrodiisoeugenolCat No HY-N0589
Dehydrodiisoeugenol is isolated from Myristica shows anti-inflammatory andfragrans Houtt
anti-bacterial actions Dehydrodiisoeugenolinhibits LPS- stimulated activation andNF-κBcyclooxygenase ( )-2 gene expression in murineCOXmacrophages
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
DehydroevodiamineCat No HY-N2106
Dehydroevodiamine is a major bioactive quinazolinealkaloid isolated from has anEvodiae Fructusantiarrhythmic effect in guinea-pig ventricularmyocytes
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Deracoxib (SC 046 SC 46 SC 59046) Cat No HY-17509
Deracoxib a selective cyclooxygenase-2 inhibitoris a non-narcotic non-steroidal anti-inflammatorydrug (NSAID)
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Desmethyl CelecoxibCat No HY-118139
Desmethyl Celecoxib (compound 3b) is a selectivecyclooxygenase-2 ( ) inhibitor ( =32 nM)COX-2 IC50
with anti-inflammatory activities DesmethylCelecoxib is an analog of Celecoxib andwith the optimal yield of 75
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
DiclofenacCat No HY-15036
Diclofenac is a potent and nonselectiveanti-inflammatory agent acts as a inhibitorCOXwith s of 4 nM 13 nM for human COX-1 andIC50
COX-2 in CHO cells and 51 084 μM for ovineCOX-1 and COX-2 respectively
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Diclofenac diethylamineCat No HY-15036A
Diclofenac diethylamine is a potent andnonselective anti-inflammatory agent acts as a
inhibitor with s of 4 nM 13 nM forCOX IC50
human COX-1 and COX-2 in CHO cells and 51 084μM for ovine COX-1 and COX-2 respectively
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Diclofenac Sodium (GP 45840) Cat No HY-15037
Diclofenac Sodium (GP 45840) is a potent andnonselective anti-inflammatory agent acts as a
inhibitor with s of 4 nM 13 nM forCOX IC50
human COX-1 and COX-2 in CHO cells and 51 084μM for ovine COX-1 and COX-2 respectively
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g
wwwMedChemExpresscom 5
Diflunisal (MK-647) Cat No HY-18342
Diflunisal (MK-647) is a salicylate derivativewith nonsteroidal anti-inflammatory and uricosuricproperties which is used alone as an analgesicand in rheumatoid arthritis patients Themechanism of action of diflunisal is as aCyclooxygenase ( ) InhibitorCOX
Purity 9937Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Eicosatetraynoic acid (ETYA) Cat No HY-124108
Eicosatetraynoic acid (ETYA) is a nonspecificinhibitor of and ( =8cyclooxygenase lipoxygenase ID50
μM and 4 μM respectively) Eicosatetraynoic acid(ETYA) activates PPARα and PPARγ chimeras at 10microM
Purity gt98Clinical DataSize 1 mg
Esculentoside ACat No HY-N0632
Esculentoside A (EsA) a kind of triterpenesaponin isolated from roots of Phytolacca esculentaEsculentoside A (EsA) possesses anti-inflammatoryactivity in acute and chronic experimental modelshas selective inhibitory activity towardscyclooxygenase-2 ( )COX-2
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Ethyl CaffeateCat No HY-N6966
Ethyl Caffeate is a natural phenolic compoundisolated from Bidens pilosa
Purity 9891Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Etodolac (AY-24236) Cat No HY-76251
Etodolac (AY-24236) is a non-steroidalanti-inflammatory compound that is a non-selectiveinhibitor of COX (IC =535 nM)50
Purity 9910Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Etoricoxib (MK-0663 L-791456) Cat No HY-15321
Etoricoxib (MK-0663) is a non steroidalanti-inflammatory agent acting as a selective andorally active inhibitor with s of 11COX-2 IC50
μM and 116 μM for COX-2 and COX-1 in human wholeblood
Purity 9992Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Etoricoxib D4 (MK-0663 D4 L-791456 D4) Cat No HY-15321S
Etoricoxib D4 (MK-0663 D4) is a deuterium labeledEtoricoxib Etoricoxib is a non steroidalanti-inflammatory agent acting as a selective andorally active inhibitor with s of 11COX-2 IC50
μM and 116 μM for COX-2 and COX-1 in human wholeblood
Purity 9935Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg
Fenofibric acid (FNF acid) Cat No HY-B0760
Fenofibric acid an active metabolite offenofibrate is a activitor with s ofPPAR EC50
224 microM 147 microM and 106 microM for PPARα PPARγ andPPARδ respectively Fenofibric acid also inhibits
enzyme activity with an of 48 nMCOX-2 IC50
Purity 9938Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Fenoprofen CalciumCat No HY-B0288A
Fenoprofen Calcium is a nonsteroidalanti-inflammatory antiarthritic agent
Purity gt98Clinical Data LaunchedSize 500 mg 1 g 5 g
Fenoprofen Calcium hydrate (Fenoprofen calcium salt dihydrate) Cat No HY-B0288B
Fenoprofen Calcium hydrate is a nonsteroidalanti-inflammatory antiarthritic agent
Purity 9935Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
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Firocoxib (ML 1785713) Cat No HY-14670
Firocoxib(ML 1785713) is a potent and selectivecyclooxygenase (COX)-2 inhibitor with IC50 of 013uM 58 fold sensitivity for COX2 VSCOX1
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
FK 3311 (COX-2 Inhibitor V) Cat No HY-14445
FK 3311 (COX-2 Inhibitor V) is a selectiveinhibitor of with antiinflammatory agentCOX-2
Purity 9806Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
Flosulide (ZK 38997 CGP 28238) Cat No HY-U00083
Flosulide is a potent and selective COX-2inhibitor used for the treatment for inflammatorydiseases
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Flufenamic acidCat No HY-B1221
Flufenamic acid is a non-steroidalanti-inflammatory agent inhibits cyclooxygenase( ) activates and also modulates ionCOX AMPKchannels blocking and chloride channels L-type
modulating non-selective cationCa channels2+
channels ( ) activating NSC K channels+
Purity 9992Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Flunixin meglumineCat No HY-B0386
Flunixin Meglumine is a potent inhibitor of COXused as analgesic agent with anti-inflammatory andantipyretic activity Target COX Flunixinmeglumine is a potent non-narcotic non-steroidalanalgesic agent with anti-inflammatory andantipyretic activity
Purity 9965Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
FR-188582Cat No HY-U00146
FR-188582 is a highly selective inhibitor of ( )-2 with an value of 17cyclooxygenase COX IC50
nM
Purity 9921Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Gallic acid (345-Trihydroxybenzoic acid) Cat No HY-N0523
Gallic acid is an antioxidant which can inhibitboth COX-2
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Ginsenoside C-K (Ginsenoside compound K Ginsenoside K) Cat No HY-N0904
Ginsenoside C-K a bacterial metabolite of G-Rb1exhibits anti-inflammatory effects by reducing iNOSand Ginsenoside C-K exhibits an inhibitionCOX-2against the activity of and inCYP2C9 CYP2A6human liver microsomes with s of 320plusmn36 μMIC50
and 636plusmn42 μM respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ginsenoside Rb3 (Gypenoside IV) Cat No HY-N0041
Ginsenoside Rb3 is extracted from steamed Panax Ginsenoside Rb3 exhibits inhibitorynotoginseng
effect on TNFα-induced transcriptionalNF-κBactivity with an of 82 μM in 293T cellIC50
lines Ginsenoside Rb3 also inhibits the inductionof and mRNACOX-2 iNOS
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ginsenoside Rd (Gypenoside VIII) Cat No HY-N0043
Ginsenoside Rd inhibits TNFα-induced NF-κBtranscriptional activity with an ofIC50
1205plusmn082 μM in HepG2 cells Ginsenoside Rdinhibits expression of and mRNACOX-2 iNOSGinsenoside Rd also inhibits influxCa2+
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
wwwMedChemExpresscom 7
Ginsenoside Rg5Cat No HY-N0908
Ginsenoside Rg5 is the main component of Redginseng Ginsenoside blocks binding of to itsIGF-1receptor with an of ~90 nM Ginsenoside Rg5IC50
also inhibits the mRNA expression of viaCOX-2suppression of the DNA binding activities of
NF-κB p65
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
GnetolCat No HY-126052
Gnetol is a phenolic compound isolated from theroot of Brongn Gnetol potentlyGnetum ulainhibits ( of 078 μM) and COX-1 IC50 HDACGnetol is a potent inhibitor with antyrosinase
of 45 μM for murine tyrosinase andIC50
suppresses melanin biosynthesis
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Guaiacol (2-Methoxyphenol) Cat No HY-N1380
Guaiacol a phenolic compound isolated from Guaiacresin inhibits LPS-stimulated expressionCOX-2and activation Anti-inflammatory activityNF-κB
Purity 9929Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
GW-406381Cat No HY-119304
GW406381 a highly selective cyclooxygenase-2 inhibitor attenuates spontaneous ectopic(COX-2)
discharge in sural nerves of rats followingchronic constriction injury
Purity 9959Clinical DataSize 10 mM times 1 mL 1 mg
HamaudolCat No HY-N6891
Hamaudol is a chromone isolated from Saposhnikovia Hamaudol shows significant inhibitorydivaricata
activity on and cyclooxygenase (COX)-1 COX-2activities with values of 030 057 mMIC50
respectively and has potent analgesia andanti-inflammary effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
HarpagosideCat No HY-N0396
Harpagoside is isolated from Harpagophytum Harpagoside has inhibitory effectsprocumbens (Hp)
on and activity and inhibits NOCOX-1 COX-2production
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
HexahydrocurcuminCat No HY-N0929
Hexahydrocurcumin is a natural compound whichposesses anticancer and anti-inflammatoryactivities selective COX-2 inhibitor
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Ibuprofen ((plusmn)-Ibuprofen) Cat No HY-78131
Ibuprofen is an anti-inflammatory inhibitortargeting and with s of 13 μMCOX-1 COX-2 IC50
and 370 μM respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Ibuprofen D3 ((plusmn)-Ibuprofen D3) Cat No HY-78131S
Ibuprofen D3 is a deuterium labeled IbuprofenIbuprofen is a COX-1 and COX-2 inhibitor with IC s50
of 13 μM and 370 μM
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Iguratimod (T614) Cat No HY-17009
Iguratimod is an antirheumatic agent acts as aninhibitor of with an of 20 μM (77COX-2 IC50
μgmL) but shows no effect on COX-1 Iguratimodalso inhibits macrophage migration inhibitoryfactor ( ) with an of 681 μMMIF IC50
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
8 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Imrecoxib (BAP-909) Cat No HY-114200
Imrecoxib (BAP-909) is a novel and selectivecyclooxygenase 2 ( ) inhibitor with an COX-2 IC50
value of 18 nM it also inhibits COX1- activitywith an value of 115 nM Imrecoxib (BAP-909)IC50
has anti-inflammatory effect
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 50 mg 100 mg
Indobufen (Ibustrin) Cat No HY-18763
Indobufen is a platelet aggregation inhibitorIndobufen is a reversible platelet cyclooxygenase( ) activity inhibitor Indobufen suppressesCoxthromboxane A (TxA ) synthesis Indobufen2 2
down-regulates tissue factor (TF) in monocytes
Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Indomethacin (Indometacin) Cat No HY-14397
Indomethacin is a potent and nonselectiveinhibitor of and with s of 18 nMCOX1 COX2 IC50
and 26 nM for human COX-1 and COX-2 respectivelyin CHO cells
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Inulicin (1-O-Acetylbritannilactone) Cat No HY-N0896
Inulicin (1-O-Acetylbritannilactone) is an activecompound isolated from InulicinInula Britannica L(1-O-Acetylbritannilactone) inhibits VEGF-mediatedactivation of and Src FAK
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Isoorientin (Homoorientin) Cat No HY-N0767
Isoorientin is a potent inhibitor of withCOX-2an value of 39 μMIC50
Purity 9924Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 25 mg 50 mg
JaceosidinCat No HY-N0831
Jaceosidin is a flavonoid isolated from induces apoptosis in cancerArtemisia vestita
cells activates and down-regulates Mcl-1 andBaxc-FLIP expression
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 25 mg
Ketoprofen (RP-19583) Cat No HY-B0227
Ketoprofen (RP-19583) is a non-steroidalantiinflammatory agent acting as a potentinhibitor of with s of 2 nM and 26 nMCOX IC50
for COX-1 and COX-2 in human blood monocytesrespectively
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Ketorolac (RS37619) Cat No HY-B0580
Ketorolac is a non-steroidal anti-inflammatoryagent acting as a nonselective inhibitorCOXwith s of 20 nM for COX-1 and 120 nM forIC50
COX-2
Purity gt98Clinical Data LaunchedSize 100 mg 500 mg
Ketorolac D5Cat No HY-B0580S
Ketorolac D5 is a deuterium labeled KetorolacKetorolac is a non-steroidal anti-inflammatoryagent acting as a nonselective inhibitorCOXwith s of 20 nM for COX-1 and 120 nM forIC50
COX-2
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ketorolac tromethamine salt (Ketorolac Tromethamine
Ketorolac tris salt RS37619 tromethamine salt) Cat No HY-B0138
Ketorolac tromethamine salt (RS37619 tromethaminesalt) is a non-steroidal anti-inflammatory agentacting as a nonselective inhibitor withCOX
s of 20 nM for COX-1 and 120 nM for COX-2IC50
Purity 9994Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
wwwMedChemExpresscom 9
Licofelone (ML-3000) Cat No HY-B1452
Licofelone (ML-3000) is a dual COX5-lipoxygenase inhibitor ( =021018 μM(5-LOX) IC50
respectively) for the treatment of osteoarthritisLicofelone exerts anti-inflammatory andanti-proliferative effects
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
Lornoxicam (Chlortenoxicam Ro 13-9297 TS110) Cat No HY-B0367
Lornoxicam a COX-1 and COX-2 inhibitor is a newnonsteroidal anti-inflammatory drug (NSAID)Target COX Lornoxicam showed a balancedinhibition of COX-1-2 exhibiting the lowest IC50(0005 microM0008 microM) of the large panel ofNSAIDs tested
Purity 9831Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
LoxoprofenCat No HY-B0578
Loxoprofen is a non-steroidal anti-inflammatorydrug Target COX Loxoprofen is a non-steroidalanti-inflammatory drug in the propionic acidderivatives group which also includes ibuprofenand naproxen among others
Purity 9882Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
LY 178002Cat No HY-101579
LY 178002 is a potent inhibitor of 5-lipoxygenase with of 06 μM(5-LPO) phospholipase A2 IC50
for 5-lipoxygenase inhibits cellular productionof LTB4 by human polymorphonuclear leukocytes andshows relatively weak inhibition on cyclooxygenase
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
MavacoxibCat No HY-119447
Mavacoxib is a selective oral long-acting inhibitor and acyclooxygenase-2 (COX-2)
long-acting non-steroidal anti-inflammatory drug(NSAID) Mavacoxib is used to treat pain andinflammation associated with degenerative jointdisease in dogs
Purity 9983Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Mefenamic acidCat No HY-B0574
Mefenamic acid is a non-steroidalanti-inflammatory agent acting as a competitiveinhibitor of and with s of 40hCOX-1 hCOX-2 IC50
nM and 3 μM for hCOX-1 and hCOX-2 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
MeloxicamCat No HY-B0261
Meloxicam is a non-steroidal antiinflammatoryagent inhibits activity with s of 049COX IC50
microM and 366 microM for COX-2 and COX-1 respectively
Purity 9807Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Meloxicam D4Cat No HY-B0261S
Meloxicam D4 is deuterium labeled MeloxicamMeloxicam is a non-steroidal antiinflammatoryagent inhibits COX activity with IC s of 049 microM50
and 366 microM for COX-2 and COX-1 respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Metamizole sodium hydrateCat No HY-B1279
Metamizole sodium hydrate is a potent analgesicdrug that has been demonstrated to inhibitcyclooxygenase (COX)
Purity gt980Clinical Data LaunchedSize 500 mg
Methyl Salicylate (Wintergreen oil) Cat No HY-Y0189
Methyl Salicylate (Wintergreen oil) is a topicalanalgesic and anti-inflammatory agent Also usedas a pesticide a denaturant a fragranceingredient and a flavoring agent in food andtobacco products A systemic acquired resistance(SAR) signal in tobacco
Purity 9998Clinical Data No Development ReportedSize 10 mM times 1 mL 50 mg
10 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
N-trans-Feruloyltyramine (N-feruloyltyramine Moupinamide) Cat No HY-N2410
N-trans-Feruloyltyramine (N-feruloyltyramine) analkaloid from is an inhibitor of Piper nigru COX1and with potential antioxidant propertiesCOX2N-trans-Feruloyltyramine possessesanti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
Nabumetone (BRL14777) Cat No HY-B0559
Nabumetone is an orally active non-acidicanti-inflammatory agent acts as a potent andselective inhibitor and is the prodrug ofCOX-2the active metabolite 6MNA
Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Naproxen ((S)-Naproxen) Cat No HY-15030
Naproxen is a and inhibitor withCOX-1 COX-2s of 872 and 515 μM respectively in cellIC50
assay
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Naproxen etemesil (LT-NS 001 MX 1094) Cat No HY-19675
Naproxen etemesil is a lipophilic non-acidicinactive prodrug of naproxen that is hydrolysed topharmacologically active Naproxen once absorbedNaproxen is a and inhibitor withCOX-1 COX-2
s of 872 and 515 μM respectively in cellIC50
assay
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Naproxen sodiumCat No HY-15030A
Naproxen sodium is a and inhibitorCOX-1 COX-2with s of 872 and 515 μM respectively inIC50
cell assay
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) Cat No HY-N0722
Neochlorogenic acid is a natural polyphenoliccompound found in dried fruits and other plantsNeochlorogenic acid inhibits the production of
and Neochlorogenic acid suppressesTNF-α IL-1β protein expressioniNOS and COX-2
Purity 9946Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Nepafenac (AHR 9434 AL 6515) Cat No HY-17357
Nepafenac(AHR 9434 AL 6515 Nevanac) is aselective COX-2 inhibitor is prodrug of AmfenacIC50 value Target COX-2 Nepafenac is a NSAID(nonsteroidal anti inflammatory drug) that isroutinely used in opthamology to control painfollowing cataract surgery
Purity 9514Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Nepafenac D5 (AHR-9434 D5 AL-6515 D5) Cat No HY-17357S
Nepafenac D5 is the deuterium labeled Nepafenacwhich is a selective COX-2 inhibitor
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Nimesulide (R805) Cat No HY-B0363
Nimesulide is a selective inhibitor withCOX-2s of 70 nM-70 μM in a time-dependent mannerIC50
but it shows no effect on COX-1 (IC gt100 μM)50
Nimesulide has potent anti-inflammatory analgesicand antipyretic properties
Purity 9991Clinical Data Phase 4Size 10 mM times 1 mL 100 mg 500 mg
Nimesulide D5Cat No HY-B0363S
Nimesulide D5 is a deuterium labeled NimesulideNimesulide is a selective inhibitor withCOX-2
s of 70 nM-70 μM in a time-dependent mannerIC50
but it shows no effect on COX-1 (IC gt100 μM)50
Nimesulide has potent anti-inflammatory analgesicand antipyretic properties
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 11
Nitroaspirin (NCX 4016) Cat No HY-123823
Nitroaspirin (NCX 4016) is a nitric oxide (NO)donor and a nitro-derivative of Aspirin whichcombines with Nitroaspirin to inhibitcyclooxygenase
Purity gt98Clinical DataSize 1 mg 5 mg
Nitroflurbiprofen (HCT 1206 NO-flurbiprofen Nitroxybutyl flurbiprofen) Cat No HY-U00013
Nitroflurbiprofen is a ( )cyclooxygenase COXinhibitor with nitric oxide (NO)-donatingproperties modulates the increased intrahepaticvascular tone in portal hypertensive cirrhoticrats
Purity 9964Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
NS-398Cat No HY-13913
NS-398 is a non-steroidal an-inflammatory agentwith analgesic and antipyretic effects andselectively inhibits prostaglandin GH synthase2cyclooxygenase 2 ( ) activity with an COX-2 IC50
of 38 μM and has no effect on COX-1 at 100 μM
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Oxaprozin (Oxaprozinum Wy21743) Cat No HY-B0808
Oxaprozin is an inhibitor of both andCOX-1 with s of 22 μM and 36 μM for humanCOX-2 IC50
platelet COX-1 and IL-1-stimulated human synovialcell COX-2 respectively Oxaprozin also inhibitsthe activation of NF-κB
Purity 9963Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Oxaprozin D4 (Wy-21743 D4) Cat No HY-B0808S
Oxaprozin D4 is the deuterium labeled Oxaprozinwhich is a non-steroidal anti-inflammatory drug(NSAID)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
Pamicogrel (KBT3022) Cat No HY-U00175
Pamicogrel (KBT3022) is a ( )cyclooxygenase COXinhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Paradol ([6]-Gingerone [6]-Paradol) Cat No HY-14617
Paradol is a pungent phenolic substance found inginger and other Zingiberaceae plants Paradol isan effective inhibitor of tumor promotion in mouseskin carcinogenesis binds to cyclooxygenase
active site(COX)-2
Purity 9988Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Parecoxib (SC 69124) Cat No HY-17474
Parecoxib is a potent and selective COX-2inhibitor IC50 value Target COX-2 in vitro Theprodrug Parecoxib as well as its active metaboliteval have a specific affinity to the cannabinoid(CB) receptor measured in CB1-expressing HEK 293cells and rat brain tissue
Purity 9932Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Parecoxib Sodium (SC 69124A) Cat No HY-17474A
Parecoxib Sodium (SC 69124A) is a potent andselective COX-2 inhibitor
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
PelubiprofenCat No HY-12383
Pelubiprofen an orally active and non-steroidalanti-inflammatory drug is a member of the2-arylpropionic acid family and has relativelyselective effects on activityCOX-2
Purity gt98Clinical Data No Development ReportedSize 100 mg 250 mg 500 mg
12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Phenacetin (Acetophenetidin) Cat No HY-B0476
Phenacetin is a non-opioid analgesic withoutanti-inflammatory properties inhibits COX-3activity Target COX Phenacetin is apain-relieving and fever-reducing drug Phenacetinwas withdrawn from the Canadian market in June1973 due to concerns regarding nephropathy
Purity 9909Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
PhenylbutazoneCat No HY-B0230
Phenylbutazone is used as a non-steroidalanti-inflammatory agent for the treatment ofchronic pain including the symptoms of arthritisTarget Others Phenylbutazone was originally madeavailable for use in humans for the treatment ofrheumatoid arthritis and gout in 1949
Purity 9886Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg
Piroxicam (CP-16171) Cat No HY-B0253
Piroxicam (CP-16171) is a non-steroidalanti-inflammatory drugs acts as a inhibitorCOXwith s of 47 25 μM for human monocyte COX-1IC50
and COX-2 respectively
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g 10 g
Piroxicam D3 (CP-16171 D3) Cat No HY-B0253S
Piroxicam D3 (CP-16171 D3) is deuterium labeledPiroxicam Piroxicam is a non-steroidalanti-inflammatory drugs acts as a COX inhibitorwith IC s of 47 25 μM for human monocyte COX-150
and COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Prim-O-glucosylcimifuginCat No HY-N0635
Prim-O-glucosylcimifugin exerts anti-inflammatoryeffects through the inhibition of and iNOS COX-2expression by through regulating JAK2STAT3signaling
Purity 9976Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Propyphenazone (4-Isopropylantipyrine Isopropylphenazone) Cat No HY-A0273
Propyphenazone is a pyrazolone derivative withanti-inflammatory analgesic and antipyreticactivity Propyphenazone-based analogues asprodrugs and selective cyclooxygenase-2inhibitors
Purity 9994Clinical Data LaunchedSize 10 mM times 1 mL 250 mg
PsoralidinCat No HY-N0232
Psoralidin isolated from the seed of Psoralea is a dual inhibitor of andcorylifolia COX-2
regulates ionizing radiation (IR)-induced5-LOXpulmonary inflammationAnti-canceranti-bacterial and anti-inflammatory properties
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg
Rebamipide (OPC12759 Proamipide) Cat No HY-B0360
Rebamipide (OPC12759) is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Rebamipide D4 (OPC12759 D4 Proamipide D4) Cat No HY-B0360S
Rebamipide D4 (OPC12759 D4) is deuterium labeledRebamipide Rebamipide is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Revaprazan hydrochlorideCat No HY-N7067
Revaprazan hydrochloride is a novel acid pumpantagonist ( ) Revaprazan hydrochlorideAPAreduces expression and has significantCOX-2anti-inflammatory actions activities in H pyloriinfection
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 13
RHC 80267 (U-57908) Cat No HY-107416
RHC 80267 (U-57908) is a potent and selectiveinhibitor of (withdiacylglycerol lipase (DAGL)
of 4 μM in canine platelets) RHC-80267IC50
inhibits activity with an of 4cholinesterase IC50
μM thereby enhancing the relaxation evoked byacetylcholine
Purity gt98Clinical Data No Development ReportedSize 10 mM1m 10 mg 25 mg 50 mg 100 mg
Roburic acidCat No HY-N0481
Roburic acid a tetracyclic triterpenoid found in acts as an inhibitor ofGentiana macrophylla
with s of 5 and 9 μM for COX-1 andCOX IC50
COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Rofecoxib (MK 966) Cat No HY-17372
Rofecoxib is a potent specific and orally active inhibitor with s of 26 and 18 nM forCOX-2 IC50
human COX-2 in human osteosarcoma cells andChinese hamster ovary cells with a 1000-foldselectivity for COX-2 over human COX-1 (IC gt50
50 μM in U937 cells and gt 15 μM inhellip
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Rutaecarpine (Rutecarpine) Cat No HY-N0147
Rutaecarpine an alkaloid of isEvodia rutaecarpaan inhibitor of with an value of 028COX-2 IC50
μM
Purity 9911Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
RWJ 63556Cat No HY-U00022
RWJ 63556 is an orally active COX-2 inhibitor withselective5-lipoxygenase
anti-inflammatory activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
S-(+)-Ketoprofen ((S)-Ketoprofen Dexketoprofen) Cat No HY-B2137
S-(+)-Ketoprofen is a potent inhibitor of both and with s of 19 and 27 nMCOX-1 COX-2 IC50
respectively
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
S-(+)-Marmesin ((+)-Marmesin (S)-Marmesin) Cat No HY-N2176
S-(+)-Marmesin is a natural coumarin exhibiting dual inhibitory activityCOX-25-LOX
Purity 9904Clinical Data No Development ReportedSize 2 mg 5 mg 10 mg 25 mg 50 mg
S-2474Cat No HY-19212
S-2474 is an inhibitor of and COX-2 5-lipoxygenase with s of 11 nM and 27 μM for COX-2(5-LO) IC50
and COX-1 in human intact cells and used as anonsteroidal anti-inflammatory drug
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Salicin (D-(minus)-Salicin Salicoside) Cat No HY-N0149
Salicin is a natural inhibitorCOX
Purity 9960Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
Salicylic acid (2-Hydroxybenzoic acid) Cat No HY-B0167
Salicylic acid inhibits cyclo-oxygenase-2 ( )COX-2activity independently of transcription factor(NF-κB) activation
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
14 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SC-560Cat No HY-59105
SC-560 is a potent and selective inhibitorCOX-1with an of 9 nMIC50
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SC57666Cat No HY-U00129
SC57666 is a selective inhibitor with anCOX2 of 26 nMIC50
Purity 9894Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 20 mg
SC58451Cat No HY-U00239
SC58451 is a potent and selective Cox-2inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Sodium Salicylate (Salicylic acid sodium salt
2-Hydroxybenzoic acid sodium salt) Cat No HY-B0167A
Sodium Salicylate inhibits cyclo-oxygenase-2( ) activity independently of transcriptionCOX-2factor (NF-κB) activation
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
Sulindac (MK-231) Cat No HY-B0008
Sulindac (MK-231) is a non-steroidalantiinflammatory agent acts as a COX-2inhibitor and inhibits overexpression of COX-2
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
SyringaldehydeCat No HY-N1390
Syringaldehyde is a polyphenolic compoundbelonging to the group of flavonoids and is foundin different plant species like Manihot
and esculenta Magnolia officinalisSyringaldehyde moderately inhibits activityCOX-2with an of 35 μgmLIC50
Purity 9996Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Tenidap (CP-66248) Cat No HY-105028
Tenidap a non-steroidal anti-inflammatory drugis a selective inhibitor with valuesCOX-1 IC50
of 003 microM and 12 microM for COX-1 and COX-2respectively Tenidap has anti-inflammatory andantirheumatic properties Tenidap is also aspecific SLC26A3 inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tenoxicam (Ro-12-0068) Cat No HY-B0440
Tenoxicam (Ro-12-0068) an antiinflammatory agentwith analgesic and antipyretic properties
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) Cat No HY-112731
TFAP is a selective cyclooxygenase-1 (COX-1)inhibitor with an of 08 μMIC50
Purity 9997Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Thioflosulide (L-745337) Cat No HY-19217
Thioflosulide (L-745337) is a selective inhibitor with an ofcyclooxygenase-2 (COX2) IC50
23 nM and shows anti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
wwwMedChemExpresscom 15
Tilmacoxib (JTE522 JTP19605 RWJ57504) Cat No HY-U00197
Tilmacoxib (JTE522) is a highly selectivetime-dependent and irreversible human COX-2inhibitor with an of 85 nM in an enzymeIC50
assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Timegadine (SR1368) Cat No HY-100125
Timegadine a new antiinflammatory agent is foundto be a potent competitive inhibitor of
( ) and withcyclo-oxygenase COX lipo-oxygenases ranging from 5 nM (washed rabbit platelets)IC50
to 20 μM (rat brain) for COX and 100 μM forlipo-oxygenase both in the cytosol fractionhellip
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tolfenamic Acid (GEA 6414) Cat No HY-B0335
Tolfenamic Acid (GEA 6414) is a non-steroidalanti-inflammatory and anti-cancer agentselectively inhibits with an of 1349COX-2 IC50
μM (353 μgmL) in LPS-treated (COX-2) canine DH82monocytemacrophage cells but shows no effect onCOX-1
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 10 g
Tolmetin sodium dihydrateCat No HY-B1489
Tolmetin sodium dihydrate is a non-steroidalantiinflammatory agent and acts as anon-selective inhibitorCOX
Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
TriflusalCat No HY-B0531
Triflusal irreversibly inhibits the production ofthromboxane-B2 in platelets by acetylatingcycloxygenase-1 Target COX Triflusal at 10 mM100 mM and 1 M decreases LDH efflux in rat brainslices after anoxiareoxygenation by 24 35 and49 respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Valdecoxib (SC 65872) Cat No HY-15762
Valdecoxib is a highly potent and selectiveinhibitor of with s of 5 nM and 140 μMCOX-2 IC50
for COX-2 and COX-1 respeceively Valdecoxib canbe used in the research of arthritis and pain
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Veratric acid (34-Dimethoxybenzoic acid) Cat No HY-N2007
Veratric acid (34-Dimethoxybenzoic acid) is anorally active phenolic compound derived fromvegetables and fruits has antioxidant andanti-inflammatory activities
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
XanthohumolCat No HY-N1067
Xanthohumol is one of the principal flavonoidsisolated from hops the inhibitor ofdiacylglycerol acetyltransferase ( ) DGAT COX-1and COX-2 and shows anti-cancer andanti-angiogenic activities
Purity 9968Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 25 mg
Zaltoprofen (CN100) Cat No HY-B0619
Zaltoprofen(CN100) is an inhibitor of COX fortreatment of arthritis
Purity 9909Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
[10]-ShogaolCat No HY-N2434
[10]-Shogaol is an antioxidant from Zingiber for human skin cell growth and aofficinale
migration enhancer [10]-Shogaol inhibits COX-2with an of 75 μM and has antiproliferationIC50
activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
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[8]-ShogaolCat No HY-N2435
-Shogaol one of the pungent phenolic compounds inginger exhibits anti-platelet activity ( =5IC50
μM) and inhibits COX-2 ( =175 μM) -ShogaolIC50
induces apoptosis in human leukemia cells
Purity 9918Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-Humulene (Humulene α-Caryophyllene) Cat No HY-N6968
α-Humulene is a main constituent of Tanacetum L (Asteraceae) essential oil withvulgare
anti-inflammation (IC =15plusmn2 microgmL) α-Humulene50
inhibits and expressionCOX-2 iNOS
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-ChaconineCat No HY-129113
α-Chaconine isolated from a Solanum L cv Jayoung inhibits thetuberosum
expressions of and atCOX-2 IL-1β IL-6 TNF-αthe transcriptional level
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 17
Aspirin (Acetylsalicylic Acid ASA) Cat No HY-14654
Aspirin is a non-selective and irreversibleinhibitor of and with s of 5 andCOX-1 COX-2 IC50
210 μgmL
Purity 9990Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
ATB-346Cat No HY-15028
ATB-346 is a novel hydrogen sulphide-releasingderivative of naproxen with markedly reducedtoxicity
Purity 9853Clinical Data Phase 1Size 10 mM times 1 mL 10 mg 50 mg 100 mg
Benzoylgomisin OCat No HY-N2266
Benzoylgomisin O isolated from Schisandra has inhibitory activity againstrubriflora
and enzymes and15-LOX COX-1 COX-2anti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
ByakangelicolCat No HY-N0074
Byakangelicol isolated from Angelica dahuricainhibits interleukin-1beta (IL-1beta) -inducedprostaglandin E2 (PGE2) release in A549 cellsmediated by suppression of cyclooxygenase-2
expression and the activity of COX-2(COX-2)enzyme
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
CafestolCat No HY-N6257
Cafestol one of the major components of coffeeis a coffee-specific diterpene from Cafestol is a
inhibitor for AP-1-targeted activity againstERK production and the mRNA expression ofPGE2
in LPS-activated RAW2647cyclooxygenase (COX)-2cells
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
CarprofenCat No HY-B1227
Carprofen is a nonsteroid anti-inflammatory agentacts as a multi-target inhibitor withFAAHCOX
s of 39 μM 223 μM and 786 μM for COX-2IC50
COX-1 and FAAH respectively
Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Catechin ((+)-Catechin Cianidanol Catechuic acid) Cat No HY-N0898
Catechin inhibits cyclooxygenase-1 ( ) withCOX-1an of 14 μMIC50
Purity 9923Clinical Data Phase 4Size 10 mM times 1 mL 10 mg 50 mg 100 mg
Celecoxib (SC 58635) Cat No HY-14398
Celecoxib is a selective inhibitor with anCOX-2 of 40 nMIC50
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 1 g
ColumbinCat No HY-N0389
Columbin is a diterpenoid furanolactone withanti-inflammation activity
Purity 9886Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
COX-2-IN-1Cat No HY-U00275
COX-2-IN-1 is potent and slective inhibitorCOX-2with an of 39 μMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
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COX-2-IN-2Cat No HY-101655
COX-2-IN-2 is a selective and inducible COX2inhibitor with an of 024 μM COX-2-IN-1 isIC50
an anti-inflammatory compound withanti-inflammatory and analgesic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
COX5-LO-IN-1 (Atreleuton analog) Cat No HY-U00347
COX5-LO-IN-1 (Atreleuton analog) is an inhibitorof and usedcylooxygenase 5-lipoxygenase (5-LO)for the research of inflammatory and allergicdisease states
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Crocin IICat No HY-N0698
Crocin II is isolated from the fruit of Gardenia with antioxidant anticancer andjasminoides
antidepressant activity Crocin II inhibits NOproduction with an value of 311 μM CrocinIC50
II suppresses the expressions of protein and m-RNAof and iNOS COX-2
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
DehydrodiisoeugenolCat No HY-N0589
Dehydrodiisoeugenol is isolated from Myristica shows anti-inflammatory andfragrans Houtt
anti-bacterial actions Dehydrodiisoeugenolinhibits LPS- stimulated activation andNF-κBcyclooxygenase ( )-2 gene expression in murineCOXmacrophages
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
DehydroevodiamineCat No HY-N2106
Dehydroevodiamine is a major bioactive quinazolinealkaloid isolated from has anEvodiae Fructusantiarrhythmic effect in guinea-pig ventricularmyocytes
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Deracoxib (SC 046 SC 46 SC 59046) Cat No HY-17509
Deracoxib a selective cyclooxygenase-2 inhibitoris a non-narcotic non-steroidal anti-inflammatorydrug (NSAID)
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Desmethyl CelecoxibCat No HY-118139
Desmethyl Celecoxib (compound 3b) is a selectivecyclooxygenase-2 ( ) inhibitor ( =32 nM)COX-2 IC50
with anti-inflammatory activities DesmethylCelecoxib is an analog of Celecoxib andwith the optimal yield of 75
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
DiclofenacCat No HY-15036
Diclofenac is a potent and nonselectiveanti-inflammatory agent acts as a inhibitorCOXwith s of 4 nM 13 nM for human COX-1 andIC50
COX-2 in CHO cells and 51 084 μM for ovineCOX-1 and COX-2 respectively
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Diclofenac diethylamineCat No HY-15036A
Diclofenac diethylamine is a potent andnonselective anti-inflammatory agent acts as a
inhibitor with s of 4 nM 13 nM forCOX IC50
human COX-1 and COX-2 in CHO cells and 51 084μM for ovine COX-1 and COX-2 respectively
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Diclofenac Sodium (GP 45840) Cat No HY-15037
Diclofenac Sodium (GP 45840) is a potent andnonselective anti-inflammatory agent acts as a
inhibitor with s of 4 nM 13 nM forCOX IC50
human COX-1 and COX-2 in CHO cells and 51 084μM for ovine COX-1 and COX-2 respectively
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g
wwwMedChemExpresscom 5
Diflunisal (MK-647) Cat No HY-18342
Diflunisal (MK-647) is a salicylate derivativewith nonsteroidal anti-inflammatory and uricosuricproperties which is used alone as an analgesicand in rheumatoid arthritis patients Themechanism of action of diflunisal is as aCyclooxygenase ( ) InhibitorCOX
Purity 9937Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Eicosatetraynoic acid (ETYA) Cat No HY-124108
Eicosatetraynoic acid (ETYA) is a nonspecificinhibitor of and ( =8cyclooxygenase lipoxygenase ID50
μM and 4 μM respectively) Eicosatetraynoic acid(ETYA) activates PPARα and PPARγ chimeras at 10microM
Purity gt98Clinical DataSize 1 mg
Esculentoside ACat No HY-N0632
Esculentoside A (EsA) a kind of triterpenesaponin isolated from roots of Phytolacca esculentaEsculentoside A (EsA) possesses anti-inflammatoryactivity in acute and chronic experimental modelshas selective inhibitory activity towardscyclooxygenase-2 ( )COX-2
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Ethyl CaffeateCat No HY-N6966
Ethyl Caffeate is a natural phenolic compoundisolated from Bidens pilosa
Purity 9891Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Etodolac (AY-24236) Cat No HY-76251
Etodolac (AY-24236) is a non-steroidalanti-inflammatory compound that is a non-selectiveinhibitor of COX (IC =535 nM)50
Purity 9910Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Etoricoxib (MK-0663 L-791456) Cat No HY-15321
Etoricoxib (MK-0663) is a non steroidalanti-inflammatory agent acting as a selective andorally active inhibitor with s of 11COX-2 IC50
μM and 116 μM for COX-2 and COX-1 in human wholeblood
Purity 9992Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Etoricoxib D4 (MK-0663 D4 L-791456 D4) Cat No HY-15321S
Etoricoxib D4 (MK-0663 D4) is a deuterium labeledEtoricoxib Etoricoxib is a non steroidalanti-inflammatory agent acting as a selective andorally active inhibitor with s of 11COX-2 IC50
μM and 116 μM for COX-2 and COX-1 in human wholeblood
Purity 9935Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg
Fenofibric acid (FNF acid) Cat No HY-B0760
Fenofibric acid an active metabolite offenofibrate is a activitor with s ofPPAR EC50
224 microM 147 microM and 106 microM for PPARα PPARγ andPPARδ respectively Fenofibric acid also inhibits
enzyme activity with an of 48 nMCOX-2 IC50
Purity 9938Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Fenoprofen CalciumCat No HY-B0288A
Fenoprofen Calcium is a nonsteroidalanti-inflammatory antiarthritic agent
Purity gt98Clinical Data LaunchedSize 500 mg 1 g 5 g
Fenoprofen Calcium hydrate (Fenoprofen calcium salt dihydrate) Cat No HY-B0288B
Fenoprofen Calcium hydrate is a nonsteroidalanti-inflammatory antiarthritic agent
Purity 9935Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
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Firocoxib (ML 1785713) Cat No HY-14670
Firocoxib(ML 1785713) is a potent and selectivecyclooxygenase (COX)-2 inhibitor with IC50 of 013uM 58 fold sensitivity for COX2 VSCOX1
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
FK 3311 (COX-2 Inhibitor V) Cat No HY-14445
FK 3311 (COX-2 Inhibitor V) is a selectiveinhibitor of with antiinflammatory agentCOX-2
Purity 9806Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
Flosulide (ZK 38997 CGP 28238) Cat No HY-U00083
Flosulide is a potent and selective COX-2inhibitor used for the treatment for inflammatorydiseases
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Flufenamic acidCat No HY-B1221
Flufenamic acid is a non-steroidalanti-inflammatory agent inhibits cyclooxygenase( ) activates and also modulates ionCOX AMPKchannels blocking and chloride channels L-type
modulating non-selective cationCa channels2+
channels ( ) activating NSC K channels+
Purity 9992Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Flunixin meglumineCat No HY-B0386
Flunixin Meglumine is a potent inhibitor of COXused as analgesic agent with anti-inflammatory andantipyretic activity Target COX Flunixinmeglumine is a potent non-narcotic non-steroidalanalgesic agent with anti-inflammatory andantipyretic activity
Purity 9965Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
FR-188582Cat No HY-U00146
FR-188582 is a highly selective inhibitor of ( )-2 with an value of 17cyclooxygenase COX IC50
nM
Purity 9921Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Gallic acid (345-Trihydroxybenzoic acid) Cat No HY-N0523
Gallic acid is an antioxidant which can inhibitboth COX-2
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Ginsenoside C-K (Ginsenoside compound K Ginsenoside K) Cat No HY-N0904
Ginsenoside C-K a bacterial metabolite of G-Rb1exhibits anti-inflammatory effects by reducing iNOSand Ginsenoside C-K exhibits an inhibitionCOX-2against the activity of and inCYP2C9 CYP2A6human liver microsomes with s of 320plusmn36 μMIC50
and 636plusmn42 μM respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ginsenoside Rb3 (Gypenoside IV) Cat No HY-N0041
Ginsenoside Rb3 is extracted from steamed Panax Ginsenoside Rb3 exhibits inhibitorynotoginseng
effect on TNFα-induced transcriptionalNF-κBactivity with an of 82 μM in 293T cellIC50
lines Ginsenoside Rb3 also inhibits the inductionof and mRNACOX-2 iNOS
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ginsenoside Rd (Gypenoside VIII) Cat No HY-N0043
Ginsenoside Rd inhibits TNFα-induced NF-κBtranscriptional activity with an ofIC50
1205plusmn082 μM in HepG2 cells Ginsenoside Rdinhibits expression of and mRNACOX-2 iNOSGinsenoside Rd also inhibits influxCa2+
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
wwwMedChemExpresscom 7
Ginsenoside Rg5Cat No HY-N0908
Ginsenoside Rg5 is the main component of Redginseng Ginsenoside blocks binding of to itsIGF-1receptor with an of ~90 nM Ginsenoside Rg5IC50
also inhibits the mRNA expression of viaCOX-2suppression of the DNA binding activities of
NF-κB p65
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
GnetolCat No HY-126052
Gnetol is a phenolic compound isolated from theroot of Brongn Gnetol potentlyGnetum ulainhibits ( of 078 μM) and COX-1 IC50 HDACGnetol is a potent inhibitor with antyrosinase
of 45 μM for murine tyrosinase andIC50
suppresses melanin biosynthesis
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Guaiacol (2-Methoxyphenol) Cat No HY-N1380
Guaiacol a phenolic compound isolated from Guaiacresin inhibits LPS-stimulated expressionCOX-2and activation Anti-inflammatory activityNF-κB
Purity 9929Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
GW-406381Cat No HY-119304
GW406381 a highly selective cyclooxygenase-2 inhibitor attenuates spontaneous ectopic(COX-2)
discharge in sural nerves of rats followingchronic constriction injury
Purity 9959Clinical DataSize 10 mM times 1 mL 1 mg
HamaudolCat No HY-N6891
Hamaudol is a chromone isolated from Saposhnikovia Hamaudol shows significant inhibitorydivaricata
activity on and cyclooxygenase (COX)-1 COX-2activities with values of 030 057 mMIC50
respectively and has potent analgesia andanti-inflammary effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
HarpagosideCat No HY-N0396
Harpagoside is isolated from Harpagophytum Harpagoside has inhibitory effectsprocumbens (Hp)
on and activity and inhibits NOCOX-1 COX-2production
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
HexahydrocurcuminCat No HY-N0929
Hexahydrocurcumin is a natural compound whichposesses anticancer and anti-inflammatoryactivities selective COX-2 inhibitor
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Ibuprofen ((plusmn)-Ibuprofen) Cat No HY-78131
Ibuprofen is an anti-inflammatory inhibitortargeting and with s of 13 μMCOX-1 COX-2 IC50
and 370 μM respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Ibuprofen D3 ((plusmn)-Ibuprofen D3) Cat No HY-78131S
Ibuprofen D3 is a deuterium labeled IbuprofenIbuprofen is a COX-1 and COX-2 inhibitor with IC s50
of 13 μM and 370 μM
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Iguratimod (T614) Cat No HY-17009
Iguratimod is an antirheumatic agent acts as aninhibitor of with an of 20 μM (77COX-2 IC50
μgmL) but shows no effect on COX-1 Iguratimodalso inhibits macrophage migration inhibitoryfactor ( ) with an of 681 μMMIF IC50
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
8 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Imrecoxib (BAP-909) Cat No HY-114200
Imrecoxib (BAP-909) is a novel and selectivecyclooxygenase 2 ( ) inhibitor with an COX-2 IC50
value of 18 nM it also inhibits COX1- activitywith an value of 115 nM Imrecoxib (BAP-909)IC50
has anti-inflammatory effect
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 50 mg 100 mg
Indobufen (Ibustrin) Cat No HY-18763
Indobufen is a platelet aggregation inhibitorIndobufen is a reversible platelet cyclooxygenase( ) activity inhibitor Indobufen suppressesCoxthromboxane A (TxA ) synthesis Indobufen2 2
down-regulates tissue factor (TF) in monocytes
Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Indomethacin (Indometacin) Cat No HY-14397
Indomethacin is a potent and nonselectiveinhibitor of and with s of 18 nMCOX1 COX2 IC50
and 26 nM for human COX-1 and COX-2 respectivelyin CHO cells
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Inulicin (1-O-Acetylbritannilactone) Cat No HY-N0896
Inulicin (1-O-Acetylbritannilactone) is an activecompound isolated from InulicinInula Britannica L(1-O-Acetylbritannilactone) inhibits VEGF-mediatedactivation of and Src FAK
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Isoorientin (Homoorientin) Cat No HY-N0767
Isoorientin is a potent inhibitor of withCOX-2an value of 39 μMIC50
Purity 9924Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 25 mg 50 mg
JaceosidinCat No HY-N0831
Jaceosidin is a flavonoid isolated from induces apoptosis in cancerArtemisia vestita
cells activates and down-regulates Mcl-1 andBaxc-FLIP expression
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 25 mg
Ketoprofen (RP-19583) Cat No HY-B0227
Ketoprofen (RP-19583) is a non-steroidalantiinflammatory agent acting as a potentinhibitor of with s of 2 nM and 26 nMCOX IC50
for COX-1 and COX-2 in human blood monocytesrespectively
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Ketorolac (RS37619) Cat No HY-B0580
Ketorolac is a non-steroidal anti-inflammatoryagent acting as a nonselective inhibitorCOXwith s of 20 nM for COX-1 and 120 nM forIC50
COX-2
Purity gt98Clinical Data LaunchedSize 100 mg 500 mg
Ketorolac D5Cat No HY-B0580S
Ketorolac D5 is a deuterium labeled KetorolacKetorolac is a non-steroidal anti-inflammatoryagent acting as a nonselective inhibitorCOXwith s of 20 nM for COX-1 and 120 nM forIC50
COX-2
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ketorolac tromethamine salt (Ketorolac Tromethamine
Ketorolac tris salt RS37619 tromethamine salt) Cat No HY-B0138
Ketorolac tromethamine salt (RS37619 tromethaminesalt) is a non-steroidal anti-inflammatory agentacting as a nonselective inhibitor withCOX
s of 20 nM for COX-1 and 120 nM for COX-2IC50
Purity 9994Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
wwwMedChemExpresscom 9
Licofelone (ML-3000) Cat No HY-B1452
Licofelone (ML-3000) is a dual COX5-lipoxygenase inhibitor ( =021018 μM(5-LOX) IC50
respectively) for the treatment of osteoarthritisLicofelone exerts anti-inflammatory andanti-proliferative effects
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
Lornoxicam (Chlortenoxicam Ro 13-9297 TS110) Cat No HY-B0367
Lornoxicam a COX-1 and COX-2 inhibitor is a newnonsteroidal anti-inflammatory drug (NSAID)Target COX Lornoxicam showed a balancedinhibition of COX-1-2 exhibiting the lowest IC50(0005 microM0008 microM) of the large panel ofNSAIDs tested
Purity 9831Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
LoxoprofenCat No HY-B0578
Loxoprofen is a non-steroidal anti-inflammatorydrug Target COX Loxoprofen is a non-steroidalanti-inflammatory drug in the propionic acidderivatives group which also includes ibuprofenand naproxen among others
Purity 9882Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
LY 178002Cat No HY-101579
LY 178002 is a potent inhibitor of 5-lipoxygenase with of 06 μM(5-LPO) phospholipase A2 IC50
for 5-lipoxygenase inhibits cellular productionof LTB4 by human polymorphonuclear leukocytes andshows relatively weak inhibition on cyclooxygenase
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
MavacoxibCat No HY-119447
Mavacoxib is a selective oral long-acting inhibitor and acyclooxygenase-2 (COX-2)
long-acting non-steroidal anti-inflammatory drug(NSAID) Mavacoxib is used to treat pain andinflammation associated with degenerative jointdisease in dogs
Purity 9983Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Mefenamic acidCat No HY-B0574
Mefenamic acid is a non-steroidalanti-inflammatory agent acting as a competitiveinhibitor of and with s of 40hCOX-1 hCOX-2 IC50
nM and 3 μM for hCOX-1 and hCOX-2 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
MeloxicamCat No HY-B0261
Meloxicam is a non-steroidal antiinflammatoryagent inhibits activity with s of 049COX IC50
microM and 366 microM for COX-2 and COX-1 respectively
Purity 9807Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Meloxicam D4Cat No HY-B0261S
Meloxicam D4 is deuterium labeled MeloxicamMeloxicam is a non-steroidal antiinflammatoryagent inhibits COX activity with IC s of 049 microM50
and 366 microM for COX-2 and COX-1 respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Metamizole sodium hydrateCat No HY-B1279
Metamizole sodium hydrate is a potent analgesicdrug that has been demonstrated to inhibitcyclooxygenase (COX)
Purity gt980Clinical Data LaunchedSize 500 mg
Methyl Salicylate (Wintergreen oil) Cat No HY-Y0189
Methyl Salicylate (Wintergreen oil) is a topicalanalgesic and anti-inflammatory agent Also usedas a pesticide a denaturant a fragranceingredient and a flavoring agent in food andtobacco products A systemic acquired resistance(SAR) signal in tobacco
Purity 9998Clinical Data No Development ReportedSize 10 mM times 1 mL 50 mg
10 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
N-trans-Feruloyltyramine (N-feruloyltyramine Moupinamide) Cat No HY-N2410
N-trans-Feruloyltyramine (N-feruloyltyramine) analkaloid from is an inhibitor of Piper nigru COX1and with potential antioxidant propertiesCOX2N-trans-Feruloyltyramine possessesanti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
Nabumetone (BRL14777) Cat No HY-B0559
Nabumetone is an orally active non-acidicanti-inflammatory agent acts as a potent andselective inhibitor and is the prodrug ofCOX-2the active metabolite 6MNA
Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Naproxen ((S)-Naproxen) Cat No HY-15030
Naproxen is a and inhibitor withCOX-1 COX-2s of 872 and 515 μM respectively in cellIC50
assay
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Naproxen etemesil (LT-NS 001 MX 1094) Cat No HY-19675
Naproxen etemesil is a lipophilic non-acidicinactive prodrug of naproxen that is hydrolysed topharmacologically active Naproxen once absorbedNaproxen is a and inhibitor withCOX-1 COX-2
s of 872 and 515 μM respectively in cellIC50
assay
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Naproxen sodiumCat No HY-15030A
Naproxen sodium is a and inhibitorCOX-1 COX-2with s of 872 and 515 μM respectively inIC50
cell assay
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) Cat No HY-N0722
Neochlorogenic acid is a natural polyphenoliccompound found in dried fruits and other plantsNeochlorogenic acid inhibits the production of
and Neochlorogenic acid suppressesTNF-α IL-1β protein expressioniNOS and COX-2
Purity 9946Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Nepafenac (AHR 9434 AL 6515) Cat No HY-17357
Nepafenac(AHR 9434 AL 6515 Nevanac) is aselective COX-2 inhibitor is prodrug of AmfenacIC50 value Target COX-2 Nepafenac is a NSAID(nonsteroidal anti inflammatory drug) that isroutinely used in opthamology to control painfollowing cataract surgery
Purity 9514Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Nepafenac D5 (AHR-9434 D5 AL-6515 D5) Cat No HY-17357S
Nepafenac D5 is the deuterium labeled Nepafenacwhich is a selective COX-2 inhibitor
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Nimesulide (R805) Cat No HY-B0363
Nimesulide is a selective inhibitor withCOX-2s of 70 nM-70 μM in a time-dependent mannerIC50
but it shows no effect on COX-1 (IC gt100 μM)50
Nimesulide has potent anti-inflammatory analgesicand antipyretic properties
Purity 9991Clinical Data Phase 4Size 10 mM times 1 mL 100 mg 500 mg
Nimesulide D5Cat No HY-B0363S
Nimesulide D5 is a deuterium labeled NimesulideNimesulide is a selective inhibitor withCOX-2
s of 70 nM-70 μM in a time-dependent mannerIC50
but it shows no effect on COX-1 (IC gt100 μM)50
Nimesulide has potent anti-inflammatory analgesicand antipyretic properties
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 11
Nitroaspirin (NCX 4016) Cat No HY-123823
Nitroaspirin (NCX 4016) is a nitric oxide (NO)donor and a nitro-derivative of Aspirin whichcombines with Nitroaspirin to inhibitcyclooxygenase
Purity gt98Clinical DataSize 1 mg 5 mg
Nitroflurbiprofen (HCT 1206 NO-flurbiprofen Nitroxybutyl flurbiprofen) Cat No HY-U00013
Nitroflurbiprofen is a ( )cyclooxygenase COXinhibitor with nitric oxide (NO)-donatingproperties modulates the increased intrahepaticvascular tone in portal hypertensive cirrhoticrats
Purity 9964Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
NS-398Cat No HY-13913
NS-398 is a non-steroidal an-inflammatory agentwith analgesic and antipyretic effects andselectively inhibits prostaglandin GH synthase2cyclooxygenase 2 ( ) activity with an COX-2 IC50
of 38 μM and has no effect on COX-1 at 100 μM
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Oxaprozin (Oxaprozinum Wy21743) Cat No HY-B0808
Oxaprozin is an inhibitor of both andCOX-1 with s of 22 μM and 36 μM for humanCOX-2 IC50
platelet COX-1 and IL-1-stimulated human synovialcell COX-2 respectively Oxaprozin also inhibitsthe activation of NF-κB
Purity 9963Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Oxaprozin D4 (Wy-21743 D4) Cat No HY-B0808S
Oxaprozin D4 is the deuterium labeled Oxaprozinwhich is a non-steroidal anti-inflammatory drug(NSAID)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
Pamicogrel (KBT3022) Cat No HY-U00175
Pamicogrel (KBT3022) is a ( )cyclooxygenase COXinhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Paradol ([6]-Gingerone [6]-Paradol) Cat No HY-14617
Paradol is a pungent phenolic substance found inginger and other Zingiberaceae plants Paradol isan effective inhibitor of tumor promotion in mouseskin carcinogenesis binds to cyclooxygenase
active site(COX)-2
Purity 9988Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Parecoxib (SC 69124) Cat No HY-17474
Parecoxib is a potent and selective COX-2inhibitor IC50 value Target COX-2 in vitro Theprodrug Parecoxib as well as its active metaboliteval have a specific affinity to the cannabinoid(CB) receptor measured in CB1-expressing HEK 293cells and rat brain tissue
Purity 9932Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Parecoxib Sodium (SC 69124A) Cat No HY-17474A
Parecoxib Sodium (SC 69124A) is a potent andselective COX-2 inhibitor
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
PelubiprofenCat No HY-12383
Pelubiprofen an orally active and non-steroidalanti-inflammatory drug is a member of the2-arylpropionic acid family and has relativelyselective effects on activityCOX-2
Purity gt98Clinical Data No Development ReportedSize 100 mg 250 mg 500 mg
12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Phenacetin (Acetophenetidin) Cat No HY-B0476
Phenacetin is a non-opioid analgesic withoutanti-inflammatory properties inhibits COX-3activity Target COX Phenacetin is apain-relieving and fever-reducing drug Phenacetinwas withdrawn from the Canadian market in June1973 due to concerns regarding nephropathy
Purity 9909Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
PhenylbutazoneCat No HY-B0230
Phenylbutazone is used as a non-steroidalanti-inflammatory agent for the treatment ofchronic pain including the symptoms of arthritisTarget Others Phenylbutazone was originally madeavailable for use in humans for the treatment ofrheumatoid arthritis and gout in 1949
Purity 9886Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg
Piroxicam (CP-16171) Cat No HY-B0253
Piroxicam (CP-16171) is a non-steroidalanti-inflammatory drugs acts as a inhibitorCOXwith s of 47 25 μM for human monocyte COX-1IC50
and COX-2 respectively
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g 10 g
Piroxicam D3 (CP-16171 D3) Cat No HY-B0253S
Piroxicam D3 (CP-16171 D3) is deuterium labeledPiroxicam Piroxicam is a non-steroidalanti-inflammatory drugs acts as a COX inhibitorwith IC s of 47 25 μM for human monocyte COX-150
and COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Prim-O-glucosylcimifuginCat No HY-N0635
Prim-O-glucosylcimifugin exerts anti-inflammatoryeffects through the inhibition of and iNOS COX-2expression by through regulating JAK2STAT3signaling
Purity 9976Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Propyphenazone (4-Isopropylantipyrine Isopropylphenazone) Cat No HY-A0273
Propyphenazone is a pyrazolone derivative withanti-inflammatory analgesic and antipyreticactivity Propyphenazone-based analogues asprodrugs and selective cyclooxygenase-2inhibitors
Purity 9994Clinical Data LaunchedSize 10 mM times 1 mL 250 mg
PsoralidinCat No HY-N0232
Psoralidin isolated from the seed of Psoralea is a dual inhibitor of andcorylifolia COX-2
regulates ionizing radiation (IR)-induced5-LOXpulmonary inflammationAnti-canceranti-bacterial and anti-inflammatory properties
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg
Rebamipide (OPC12759 Proamipide) Cat No HY-B0360
Rebamipide (OPC12759) is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Rebamipide D4 (OPC12759 D4 Proamipide D4) Cat No HY-B0360S
Rebamipide D4 (OPC12759 D4) is deuterium labeledRebamipide Rebamipide is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Revaprazan hydrochlorideCat No HY-N7067
Revaprazan hydrochloride is a novel acid pumpantagonist ( ) Revaprazan hydrochlorideAPAreduces expression and has significantCOX-2anti-inflammatory actions activities in H pyloriinfection
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 13
RHC 80267 (U-57908) Cat No HY-107416
RHC 80267 (U-57908) is a potent and selectiveinhibitor of (withdiacylglycerol lipase (DAGL)
of 4 μM in canine platelets) RHC-80267IC50
inhibits activity with an of 4cholinesterase IC50
μM thereby enhancing the relaxation evoked byacetylcholine
Purity gt98Clinical Data No Development ReportedSize 10 mM1m 10 mg 25 mg 50 mg 100 mg
Roburic acidCat No HY-N0481
Roburic acid a tetracyclic triterpenoid found in acts as an inhibitor ofGentiana macrophylla
with s of 5 and 9 μM for COX-1 andCOX IC50
COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Rofecoxib (MK 966) Cat No HY-17372
Rofecoxib is a potent specific and orally active inhibitor with s of 26 and 18 nM forCOX-2 IC50
human COX-2 in human osteosarcoma cells andChinese hamster ovary cells with a 1000-foldselectivity for COX-2 over human COX-1 (IC gt50
50 μM in U937 cells and gt 15 μM inhellip
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Rutaecarpine (Rutecarpine) Cat No HY-N0147
Rutaecarpine an alkaloid of isEvodia rutaecarpaan inhibitor of with an value of 028COX-2 IC50
μM
Purity 9911Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
RWJ 63556Cat No HY-U00022
RWJ 63556 is an orally active COX-2 inhibitor withselective5-lipoxygenase
anti-inflammatory activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
S-(+)-Ketoprofen ((S)-Ketoprofen Dexketoprofen) Cat No HY-B2137
S-(+)-Ketoprofen is a potent inhibitor of both and with s of 19 and 27 nMCOX-1 COX-2 IC50
respectively
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
S-(+)-Marmesin ((+)-Marmesin (S)-Marmesin) Cat No HY-N2176
S-(+)-Marmesin is a natural coumarin exhibiting dual inhibitory activityCOX-25-LOX
Purity 9904Clinical Data No Development ReportedSize 2 mg 5 mg 10 mg 25 mg 50 mg
S-2474Cat No HY-19212
S-2474 is an inhibitor of and COX-2 5-lipoxygenase with s of 11 nM and 27 μM for COX-2(5-LO) IC50
and COX-1 in human intact cells and used as anonsteroidal anti-inflammatory drug
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Salicin (D-(minus)-Salicin Salicoside) Cat No HY-N0149
Salicin is a natural inhibitorCOX
Purity 9960Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
Salicylic acid (2-Hydroxybenzoic acid) Cat No HY-B0167
Salicylic acid inhibits cyclo-oxygenase-2 ( )COX-2activity independently of transcription factor(NF-κB) activation
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
14 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SC-560Cat No HY-59105
SC-560 is a potent and selective inhibitorCOX-1with an of 9 nMIC50
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SC57666Cat No HY-U00129
SC57666 is a selective inhibitor with anCOX2 of 26 nMIC50
Purity 9894Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 20 mg
SC58451Cat No HY-U00239
SC58451 is a potent and selective Cox-2inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Sodium Salicylate (Salicylic acid sodium salt
2-Hydroxybenzoic acid sodium salt) Cat No HY-B0167A
Sodium Salicylate inhibits cyclo-oxygenase-2( ) activity independently of transcriptionCOX-2factor (NF-κB) activation
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
Sulindac (MK-231) Cat No HY-B0008
Sulindac (MK-231) is a non-steroidalantiinflammatory agent acts as a COX-2inhibitor and inhibits overexpression of COX-2
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
SyringaldehydeCat No HY-N1390
Syringaldehyde is a polyphenolic compoundbelonging to the group of flavonoids and is foundin different plant species like Manihot
and esculenta Magnolia officinalisSyringaldehyde moderately inhibits activityCOX-2with an of 35 μgmLIC50
Purity 9996Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Tenidap (CP-66248) Cat No HY-105028
Tenidap a non-steroidal anti-inflammatory drugis a selective inhibitor with valuesCOX-1 IC50
of 003 microM and 12 microM for COX-1 and COX-2respectively Tenidap has anti-inflammatory andantirheumatic properties Tenidap is also aspecific SLC26A3 inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tenoxicam (Ro-12-0068) Cat No HY-B0440
Tenoxicam (Ro-12-0068) an antiinflammatory agentwith analgesic and antipyretic properties
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) Cat No HY-112731
TFAP is a selective cyclooxygenase-1 (COX-1)inhibitor with an of 08 μMIC50
Purity 9997Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Thioflosulide (L-745337) Cat No HY-19217
Thioflosulide (L-745337) is a selective inhibitor with an ofcyclooxygenase-2 (COX2) IC50
23 nM and shows anti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
wwwMedChemExpresscom 15
Tilmacoxib (JTE522 JTP19605 RWJ57504) Cat No HY-U00197
Tilmacoxib (JTE522) is a highly selectivetime-dependent and irreversible human COX-2inhibitor with an of 85 nM in an enzymeIC50
assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Timegadine (SR1368) Cat No HY-100125
Timegadine a new antiinflammatory agent is foundto be a potent competitive inhibitor of
( ) and withcyclo-oxygenase COX lipo-oxygenases ranging from 5 nM (washed rabbit platelets)IC50
to 20 μM (rat brain) for COX and 100 μM forlipo-oxygenase both in the cytosol fractionhellip
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tolfenamic Acid (GEA 6414) Cat No HY-B0335
Tolfenamic Acid (GEA 6414) is a non-steroidalanti-inflammatory and anti-cancer agentselectively inhibits with an of 1349COX-2 IC50
μM (353 μgmL) in LPS-treated (COX-2) canine DH82monocytemacrophage cells but shows no effect onCOX-1
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 10 g
Tolmetin sodium dihydrateCat No HY-B1489
Tolmetin sodium dihydrate is a non-steroidalantiinflammatory agent and acts as anon-selective inhibitorCOX
Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
TriflusalCat No HY-B0531
Triflusal irreversibly inhibits the production ofthromboxane-B2 in platelets by acetylatingcycloxygenase-1 Target COX Triflusal at 10 mM100 mM and 1 M decreases LDH efflux in rat brainslices after anoxiareoxygenation by 24 35 and49 respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Valdecoxib (SC 65872) Cat No HY-15762
Valdecoxib is a highly potent and selectiveinhibitor of with s of 5 nM and 140 μMCOX-2 IC50
for COX-2 and COX-1 respeceively Valdecoxib canbe used in the research of arthritis and pain
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Veratric acid (34-Dimethoxybenzoic acid) Cat No HY-N2007
Veratric acid (34-Dimethoxybenzoic acid) is anorally active phenolic compound derived fromvegetables and fruits has antioxidant andanti-inflammatory activities
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
XanthohumolCat No HY-N1067
Xanthohumol is one of the principal flavonoidsisolated from hops the inhibitor ofdiacylglycerol acetyltransferase ( ) DGAT COX-1and COX-2 and shows anti-cancer andanti-angiogenic activities
Purity 9968Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 25 mg
Zaltoprofen (CN100) Cat No HY-B0619
Zaltoprofen(CN100) is an inhibitor of COX fortreatment of arthritis
Purity 9909Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
[10]-ShogaolCat No HY-N2434
[10]-Shogaol is an antioxidant from Zingiber for human skin cell growth and aofficinale
migration enhancer [10]-Shogaol inhibits COX-2with an of 75 μM and has antiproliferationIC50
activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
16 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
[8]-ShogaolCat No HY-N2435
-Shogaol one of the pungent phenolic compounds inginger exhibits anti-platelet activity ( =5IC50
μM) and inhibits COX-2 ( =175 μM) -ShogaolIC50
induces apoptosis in human leukemia cells
Purity 9918Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-Humulene (Humulene α-Caryophyllene) Cat No HY-N6968
α-Humulene is a main constituent of Tanacetum L (Asteraceae) essential oil withvulgare
anti-inflammation (IC =15plusmn2 microgmL) α-Humulene50
inhibits and expressionCOX-2 iNOS
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-ChaconineCat No HY-129113
α-Chaconine isolated from a Solanum L cv Jayoung inhibits thetuberosum
expressions of and atCOX-2 IL-1β IL-6 TNF-αthe transcriptional level
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 17
COX-2-IN-2Cat No HY-101655
COX-2-IN-2 is a selective and inducible COX2inhibitor with an of 024 μM COX-2-IN-1 isIC50
an anti-inflammatory compound withanti-inflammatory and analgesic activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
COX5-LO-IN-1 (Atreleuton analog) Cat No HY-U00347
COX5-LO-IN-1 (Atreleuton analog) is an inhibitorof and usedcylooxygenase 5-lipoxygenase (5-LO)for the research of inflammatory and allergicdisease states
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Crocin IICat No HY-N0698
Crocin II is isolated from the fruit of Gardenia with antioxidant anticancer andjasminoides
antidepressant activity Crocin II inhibits NOproduction with an value of 311 μM CrocinIC50
II suppresses the expressions of protein and m-RNAof and iNOS COX-2
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
DehydrodiisoeugenolCat No HY-N0589
Dehydrodiisoeugenol is isolated from Myristica shows anti-inflammatory andfragrans Houtt
anti-bacterial actions Dehydrodiisoeugenolinhibits LPS- stimulated activation andNF-κBcyclooxygenase ( )-2 gene expression in murineCOXmacrophages
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
DehydroevodiamineCat No HY-N2106
Dehydroevodiamine is a major bioactive quinazolinealkaloid isolated from has anEvodiae Fructusantiarrhythmic effect in guinea-pig ventricularmyocytes
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Deracoxib (SC 046 SC 46 SC 59046) Cat No HY-17509
Deracoxib a selective cyclooxygenase-2 inhibitoris a non-narcotic non-steroidal anti-inflammatorydrug (NSAID)
Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Desmethyl CelecoxibCat No HY-118139
Desmethyl Celecoxib (compound 3b) is a selectivecyclooxygenase-2 ( ) inhibitor ( =32 nM)COX-2 IC50
with anti-inflammatory activities DesmethylCelecoxib is an analog of Celecoxib andwith the optimal yield of 75
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
DiclofenacCat No HY-15036
Diclofenac is a potent and nonselectiveanti-inflammatory agent acts as a inhibitorCOXwith s of 4 nM 13 nM for human COX-1 andIC50
COX-2 in CHO cells and 51 084 μM for ovineCOX-1 and COX-2 respectively
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Diclofenac diethylamineCat No HY-15036A
Diclofenac diethylamine is a potent andnonselective anti-inflammatory agent acts as a
inhibitor with s of 4 nM 13 nM forCOX IC50
human COX-1 and COX-2 in CHO cells and 51 084μM for ovine COX-1 and COX-2 respectively
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Diclofenac Sodium (GP 45840) Cat No HY-15037
Diclofenac Sodium (GP 45840) is a potent andnonselective anti-inflammatory agent acts as a
inhibitor with s of 4 nM 13 nM forCOX IC50
human COX-1 and COX-2 in CHO cells and 51 084μM for ovine COX-1 and COX-2 respectively
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g
wwwMedChemExpresscom 5
Diflunisal (MK-647) Cat No HY-18342
Diflunisal (MK-647) is a salicylate derivativewith nonsteroidal anti-inflammatory and uricosuricproperties which is used alone as an analgesicand in rheumatoid arthritis patients Themechanism of action of diflunisal is as aCyclooxygenase ( ) InhibitorCOX
Purity 9937Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Eicosatetraynoic acid (ETYA) Cat No HY-124108
Eicosatetraynoic acid (ETYA) is a nonspecificinhibitor of and ( =8cyclooxygenase lipoxygenase ID50
μM and 4 μM respectively) Eicosatetraynoic acid(ETYA) activates PPARα and PPARγ chimeras at 10microM
Purity gt98Clinical DataSize 1 mg
Esculentoside ACat No HY-N0632
Esculentoside A (EsA) a kind of triterpenesaponin isolated from roots of Phytolacca esculentaEsculentoside A (EsA) possesses anti-inflammatoryactivity in acute and chronic experimental modelshas selective inhibitory activity towardscyclooxygenase-2 ( )COX-2
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Ethyl CaffeateCat No HY-N6966
Ethyl Caffeate is a natural phenolic compoundisolated from Bidens pilosa
Purity 9891Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Etodolac (AY-24236) Cat No HY-76251
Etodolac (AY-24236) is a non-steroidalanti-inflammatory compound that is a non-selectiveinhibitor of COX (IC =535 nM)50
Purity 9910Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Etoricoxib (MK-0663 L-791456) Cat No HY-15321
Etoricoxib (MK-0663) is a non steroidalanti-inflammatory agent acting as a selective andorally active inhibitor with s of 11COX-2 IC50
μM and 116 μM for COX-2 and COX-1 in human wholeblood
Purity 9992Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Etoricoxib D4 (MK-0663 D4 L-791456 D4) Cat No HY-15321S
Etoricoxib D4 (MK-0663 D4) is a deuterium labeledEtoricoxib Etoricoxib is a non steroidalanti-inflammatory agent acting as a selective andorally active inhibitor with s of 11COX-2 IC50
μM and 116 μM for COX-2 and COX-1 in human wholeblood
Purity 9935Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg
Fenofibric acid (FNF acid) Cat No HY-B0760
Fenofibric acid an active metabolite offenofibrate is a activitor with s ofPPAR EC50
224 microM 147 microM and 106 microM for PPARα PPARγ andPPARδ respectively Fenofibric acid also inhibits
enzyme activity with an of 48 nMCOX-2 IC50
Purity 9938Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Fenoprofen CalciumCat No HY-B0288A
Fenoprofen Calcium is a nonsteroidalanti-inflammatory antiarthritic agent
Purity gt98Clinical Data LaunchedSize 500 mg 1 g 5 g
Fenoprofen Calcium hydrate (Fenoprofen calcium salt dihydrate) Cat No HY-B0288B
Fenoprofen Calcium hydrate is a nonsteroidalanti-inflammatory antiarthritic agent
Purity 9935Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
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Firocoxib (ML 1785713) Cat No HY-14670
Firocoxib(ML 1785713) is a potent and selectivecyclooxygenase (COX)-2 inhibitor with IC50 of 013uM 58 fold sensitivity for COX2 VSCOX1
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
FK 3311 (COX-2 Inhibitor V) Cat No HY-14445
FK 3311 (COX-2 Inhibitor V) is a selectiveinhibitor of with antiinflammatory agentCOX-2
Purity 9806Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
Flosulide (ZK 38997 CGP 28238) Cat No HY-U00083
Flosulide is a potent and selective COX-2inhibitor used for the treatment for inflammatorydiseases
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Flufenamic acidCat No HY-B1221
Flufenamic acid is a non-steroidalanti-inflammatory agent inhibits cyclooxygenase( ) activates and also modulates ionCOX AMPKchannels blocking and chloride channels L-type
modulating non-selective cationCa channels2+
channels ( ) activating NSC K channels+
Purity 9992Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Flunixin meglumineCat No HY-B0386
Flunixin Meglumine is a potent inhibitor of COXused as analgesic agent with anti-inflammatory andantipyretic activity Target COX Flunixinmeglumine is a potent non-narcotic non-steroidalanalgesic agent with anti-inflammatory andantipyretic activity
Purity 9965Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
FR-188582Cat No HY-U00146
FR-188582 is a highly selective inhibitor of ( )-2 with an value of 17cyclooxygenase COX IC50
nM
Purity 9921Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Gallic acid (345-Trihydroxybenzoic acid) Cat No HY-N0523
Gallic acid is an antioxidant which can inhibitboth COX-2
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Ginsenoside C-K (Ginsenoside compound K Ginsenoside K) Cat No HY-N0904
Ginsenoside C-K a bacterial metabolite of G-Rb1exhibits anti-inflammatory effects by reducing iNOSand Ginsenoside C-K exhibits an inhibitionCOX-2against the activity of and inCYP2C9 CYP2A6human liver microsomes with s of 320plusmn36 μMIC50
and 636plusmn42 μM respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ginsenoside Rb3 (Gypenoside IV) Cat No HY-N0041
Ginsenoside Rb3 is extracted from steamed Panax Ginsenoside Rb3 exhibits inhibitorynotoginseng
effect on TNFα-induced transcriptionalNF-κBactivity with an of 82 μM in 293T cellIC50
lines Ginsenoside Rb3 also inhibits the inductionof and mRNACOX-2 iNOS
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ginsenoside Rd (Gypenoside VIII) Cat No HY-N0043
Ginsenoside Rd inhibits TNFα-induced NF-κBtranscriptional activity with an ofIC50
1205plusmn082 μM in HepG2 cells Ginsenoside Rdinhibits expression of and mRNACOX-2 iNOSGinsenoside Rd also inhibits influxCa2+
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
wwwMedChemExpresscom 7
Ginsenoside Rg5Cat No HY-N0908
Ginsenoside Rg5 is the main component of Redginseng Ginsenoside blocks binding of to itsIGF-1receptor with an of ~90 nM Ginsenoside Rg5IC50
also inhibits the mRNA expression of viaCOX-2suppression of the DNA binding activities of
NF-κB p65
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
GnetolCat No HY-126052
Gnetol is a phenolic compound isolated from theroot of Brongn Gnetol potentlyGnetum ulainhibits ( of 078 μM) and COX-1 IC50 HDACGnetol is a potent inhibitor with antyrosinase
of 45 μM for murine tyrosinase andIC50
suppresses melanin biosynthesis
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Guaiacol (2-Methoxyphenol) Cat No HY-N1380
Guaiacol a phenolic compound isolated from Guaiacresin inhibits LPS-stimulated expressionCOX-2and activation Anti-inflammatory activityNF-κB
Purity 9929Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
GW-406381Cat No HY-119304
GW406381 a highly selective cyclooxygenase-2 inhibitor attenuates spontaneous ectopic(COX-2)
discharge in sural nerves of rats followingchronic constriction injury
Purity 9959Clinical DataSize 10 mM times 1 mL 1 mg
HamaudolCat No HY-N6891
Hamaudol is a chromone isolated from Saposhnikovia Hamaudol shows significant inhibitorydivaricata
activity on and cyclooxygenase (COX)-1 COX-2activities with values of 030 057 mMIC50
respectively and has potent analgesia andanti-inflammary effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
HarpagosideCat No HY-N0396
Harpagoside is isolated from Harpagophytum Harpagoside has inhibitory effectsprocumbens (Hp)
on and activity and inhibits NOCOX-1 COX-2production
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
HexahydrocurcuminCat No HY-N0929
Hexahydrocurcumin is a natural compound whichposesses anticancer and anti-inflammatoryactivities selective COX-2 inhibitor
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Ibuprofen ((plusmn)-Ibuprofen) Cat No HY-78131
Ibuprofen is an anti-inflammatory inhibitortargeting and with s of 13 μMCOX-1 COX-2 IC50
and 370 μM respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Ibuprofen D3 ((plusmn)-Ibuprofen D3) Cat No HY-78131S
Ibuprofen D3 is a deuterium labeled IbuprofenIbuprofen is a COX-1 and COX-2 inhibitor with IC s50
of 13 μM and 370 μM
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Iguratimod (T614) Cat No HY-17009
Iguratimod is an antirheumatic agent acts as aninhibitor of with an of 20 μM (77COX-2 IC50
μgmL) but shows no effect on COX-1 Iguratimodalso inhibits macrophage migration inhibitoryfactor ( ) with an of 681 μMMIF IC50
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
8 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Imrecoxib (BAP-909) Cat No HY-114200
Imrecoxib (BAP-909) is a novel and selectivecyclooxygenase 2 ( ) inhibitor with an COX-2 IC50
value of 18 nM it also inhibits COX1- activitywith an value of 115 nM Imrecoxib (BAP-909)IC50
has anti-inflammatory effect
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 50 mg 100 mg
Indobufen (Ibustrin) Cat No HY-18763
Indobufen is a platelet aggregation inhibitorIndobufen is a reversible platelet cyclooxygenase( ) activity inhibitor Indobufen suppressesCoxthromboxane A (TxA ) synthesis Indobufen2 2
down-regulates tissue factor (TF) in monocytes
Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Indomethacin (Indometacin) Cat No HY-14397
Indomethacin is a potent and nonselectiveinhibitor of and with s of 18 nMCOX1 COX2 IC50
and 26 nM for human COX-1 and COX-2 respectivelyin CHO cells
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Inulicin (1-O-Acetylbritannilactone) Cat No HY-N0896
Inulicin (1-O-Acetylbritannilactone) is an activecompound isolated from InulicinInula Britannica L(1-O-Acetylbritannilactone) inhibits VEGF-mediatedactivation of and Src FAK
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Isoorientin (Homoorientin) Cat No HY-N0767
Isoorientin is a potent inhibitor of withCOX-2an value of 39 μMIC50
Purity 9924Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 25 mg 50 mg
JaceosidinCat No HY-N0831
Jaceosidin is a flavonoid isolated from induces apoptosis in cancerArtemisia vestita
cells activates and down-regulates Mcl-1 andBaxc-FLIP expression
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 25 mg
Ketoprofen (RP-19583) Cat No HY-B0227
Ketoprofen (RP-19583) is a non-steroidalantiinflammatory agent acting as a potentinhibitor of with s of 2 nM and 26 nMCOX IC50
for COX-1 and COX-2 in human blood monocytesrespectively
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Ketorolac (RS37619) Cat No HY-B0580
Ketorolac is a non-steroidal anti-inflammatoryagent acting as a nonselective inhibitorCOXwith s of 20 nM for COX-1 and 120 nM forIC50
COX-2
Purity gt98Clinical Data LaunchedSize 100 mg 500 mg
Ketorolac D5Cat No HY-B0580S
Ketorolac D5 is a deuterium labeled KetorolacKetorolac is a non-steroidal anti-inflammatoryagent acting as a nonselective inhibitorCOXwith s of 20 nM for COX-1 and 120 nM forIC50
COX-2
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ketorolac tromethamine salt (Ketorolac Tromethamine
Ketorolac tris salt RS37619 tromethamine salt) Cat No HY-B0138
Ketorolac tromethamine salt (RS37619 tromethaminesalt) is a non-steroidal anti-inflammatory agentacting as a nonselective inhibitor withCOX
s of 20 nM for COX-1 and 120 nM for COX-2IC50
Purity 9994Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
wwwMedChemExpresscom 9
Licofelone (ML-3000) Cat No HY-B1452
Licofelone (ML-3000) is a dual COX5-lipoxygenase inhibitor ( =021018 μM(5-LOX) IC50
respectively) for the treatment of osteoarthritisLicofelone exerts anti-inflammatory andanti-proliferative effects
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
Lornoxicam (Chlortenoxicam Ro 13-9297 TS110) Cat No HY-B0367
Lornoxicam a COX-1 and COX-2 inhibitor is a newnonsteroidal anti-inflammatory drug (NSAID)Target COX Lornoxicam showed a balancedinhibition of COX-1-2 exhibiting the lowest IC50(0005 microM0008 microM) of the large panel ofNSAIDs tested
Purity 9831Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
LoxoprofenCat No HY-B0578
Loxoprofen is a non-steroidal anti-inflammatorydrug Target COX Loxoprofen is a non-steroidalanti-inflammatory drug in the propionic acidderivatives group which also includes ibuprofenand naproxen among others
Purity 9882Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
LY 178002Cat No HY-101579
LY 178002 is a potent inhibitor of 5-lipoxygenase with of 06 μM(5-LPO) phospholipase A2 IC50
for 5-lipoxygenase inhibits cellular productionof LTB4 by human polymorphonuclear leukocytes andshows relatively weak inhibition on cyclooxygenase
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
MavacoxibCat No HY-119447
Mavacoxib is a selective oral long-acting inhibitor and acyclooxygenase-2 (COX-2)
long-acting non-steroidal anti-inflammatory drug(NSAID) Mavacoxib is used to treat pain andinflammation associated with degenerative jointdisease in dogs
Purity 9983Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Mefenamic acidCat No HY-B0574
Mefenamic acid is a non-steroidalanti-inflammatory agent acting as a competitiveinhibitor of and with s of 40hCOX-1 hCOX-2 IC50
nM and 3 μM for hCOX-1 and hCOX-2 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
MeloxicamCat No HY-B0261
Meloxicam is a non-steroidal antiinflammatoryagent inhibits activity with s of 049COX IC50
microM and 366 microM for COX-2 and COX-1 respectively
Purity 9807Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Meloxicam D4Cat No HY-B0261S
Meloxicam D4 is deuterium labeled MeloxicamMeloxicam is a non-steroidal antiinflammatoryagent inhibits COX activity with IC s of 049 microM50
and 366 microM for COX-2 and COX-1 respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Metamizole sodium hydrateCat No HY-B1279
Metamizole sodium hydrate is a potent analgesicdrug that has been demonstrated to inhibitcyclooxygenase (COX)
Purity gt980Clinical Data LaunchedSize 500 mg
Methyl Salicylate (Wintergreen oil) Cat No HY-Y0189
Methyl Salicylate (Wintergreen oil) is a topicalanalgesic and anti-inflammatory agent Also usedas a pesticide a denaturant a fragranceingredient and a flavoring agent in food andtobacco products A systemic acquired resistance(SAR) signal in tobacco
Purity 9998Clinical Data No Development ReportedSize 10 mM times 1 mL 50 mg
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N-trans-Feruloyltyramine (N-feruloyltyramine Moupinamide) Cat No HY-N2410
N-trans-Feruloyltyramine (N-feruloyltyramine) analkaloid from is an inhibitor of Piper nigru COX1and with potential antioxidant propertiesCOX2N-trans-Feruloyltyramine possessesanti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
Nabumetone (BRL14777) Cat No HY-B0559
Nabumetone is an orally active non-acidicanti-inflammatory agent acts as a potent andselective inhibitor and is the prodrug ofCOX-2the active metabolite 6MNA
Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Naproxen ((S)-Naproxen) Cat No HY-15030
Naproxen is a and inhibitor withCOX-1 COX-2s of 872 and 515 μM respectively in cellIC50
assay
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Naproxen etemesil (LT-NS 001 MX 1094) Cat No HY-19675
Naproxen etemesil is a lipophilic non-acidicinactive prodrug of naproxen that is hydrolysed topharmacologically active Naproxen once absorbedNaproxen is a and inhibitor withCOX-1 COX-2
s of 872 and 515 μM respectively in cellIC50
assay
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Naproxen sodiumCat No HY-15030A
Naproxen sodium is a and inhibitorCOX-1 COX-2with s of 872 and 515 μM respectively inIC50
cell assay
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) Cat No HY-N0722
Neochlorogenic acid is a natural polyphenoliccompound found in dried fruits and other plantsNeochlorogenic acid inhibits the production of
and Neochlorogenic acid suppressesTNF-α IL-1β protein expressioniNOS and COX-2
Purity 9946Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Nepafenac (AHR 9434 AL 6515) Cat No HY-17357
Nepafenac(AHR 9434 AL 6515 Nevanac) is aselective COX-2 inhibitor is prodrug of AmfenacIC50 value Target COX-2 Nepafenac is a NSAID(nonsteroidal anti inflammatory drug) that isroutinely used in opthamology to control painfollowing cataract surgery
Purity 9514Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Nepafenac D5 (AHR-9434 D5 AL-6515 D5) Cat No HY-17357S
Nepafenac D5 is the deuterium labeled Nepafenacwhich is a selective COX-2 inhibitor
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Nimesulide (R805) Cat No HY-B0363
Nimesulide is a selective inhibitor withCOX-2s of 70 nM-70 μM in a time-dependent mannerIC50
but it shows no effect on COX-1 (IC gt100 μM)50
Nimesulide has potent anti-inflammatory analgesicand antipyretic properties
Purity 9991Clinical Data Phase 4Size 10 mM times 1 mL 100 mg 500 mg
Nimesulide D5Cat No HY-B0363S
Nimesulide D5 is a deuterium labeled NimesulideNimesulide is a selective inhibitor withCOX-2
s of 70 nM-70 μM in a time-dependent mannerIC50
but it shows no effect on COX-1 (IC gt100 μM)50
Nimesulide has potent anti-inflammatory analgesicand antipyretic properties
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 11
Nitroaspirin (NCX 4016) Cat No HY-123823
Nitroaspirin (NCX 4016) is a nitric oxide (NO)donor and a nitro-derivative of Aspirin whichcombines with Nitroaspirin to inhibitcyclooxygenase
Purity gt98Clinical DataSize 1 mg 5 mg
Nitroflurbiprofen (HCT 1206 NO-flurbiprofen Nitroxybutyl flurbiprofen) Cat No HY-U00013
Nitroflurbiprofen is a ( )cyclooxygenase COXinhibitor with nitric oxide (NO)-donatingproperties modulates the increased intrahepaticvascular tone in portal hypertensive cirrhoticrats
Purity 9964Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
NS-398Cat No HY-13913
NS-398 is a non-steroidal an-inflammatory agentwith analgesic and antipyretic effects andselectively inhibits prostaglandin GH synthase2cyclooxygenase 2 ( ) activity with an COX-2 IC50
of 38 μM and has no effect on COX-1 at 100 μM
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Oxaprozin (Oxaprozinum Wy21743) Cat No HY-B0808
Oxaprozin is an inhibitor of both andCOX-1 with s of 22 μM and 36 μM for humanCOX-2 IC50
platelet COX-1 and IL-1-stimulated human synovialcell COX-2 respectively Oxaprozin also inhibitsthe activation of NF-κB
Purity 9963Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Oxaprozin D4 (Wy-21743 D4) Cat No HY-B0808S
Oxaprozin D4 is the deuterium labeled Oxaprozinwhich is a non-steroidal anti-inflammatory drug(NSAID)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
Pamicogrel (KBT3022) Cat No HY-U00175
Pamicogrel (KBT3022) is a ( )cyclooxygenase COXinhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Paradol ([6]-Gingerone [6]-Paradol) Cat No HY-14617
Paradol is a pungent phenolic substance found inginger and other Zingiberaceae plants Paradol isan effective inhibitor of tumor promotion in mouseskin carcinogenesis binds to cyclooxygenase
active site(COX)-2
Purity 9988Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Parecoxib (SC 69124) Cat No HY-17474
Parecoxib is a potent and selective COX-2inhibitor IC50 value Target COX-2 in vitro Theprodrug Parecoxib as well as its active metaboliteval have a specific affinity to the cannabinoid(CB) receptor measured in CB1-expressing HEK 293cells and rat brain tissue
Purity 9932Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Parecoxib Sodium (SC 69124A) Cat No HY-17474A
Parecoxib Sodium (SC 69124A) is a potent andselective COX-2 inhibitor
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
PelubiprofenCat No HY-12383
Pelubiprofen an orally active and non-steroidalanti-inflammatory drug is a member of the2-arylpropionic acid family and has relativelyselective effects on activityCOX-2
Purity gt98Clinical Data No Development ReportedSize 100 mg 250 mg 500 mg
12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Phenacetin (Acetophenetidin) Cat No HY-B0476
Phenacetin is a non-opioid analgesic withoutanti-inflammatory properties inhibits COX-3activity Target COX Phenacetin is apain-relieving and fever-reducing drug Phenacetinwas withdrawn from the Canadian market in June1973 due to concerns regarding nephropathy
Purity 9909Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
PhenylbutazoneCat No HY-B0230
Phenylbutazone is used as a non-steroidalanti-inflammatory agent for the treatment ofchronic pain including the symptoms of arthritisTarget Others Phenylbutazone was originally madeavailable for use in humans for the treatment ofrheumatoid arthritis and gout in 1949
Purity 9886Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg
Piroxicam (CP-16171) Cat No HY-B0253
Piroxicam (CP-16171) is a non-steroidalanti-inflammatory drugs acts as a inhibitorCOXwith s of 47 25 μM for human monocyte COX-1IC50
and COX-2 respectively
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g 10 g
Piroxicam D3 (CP-16171 D3) Cat No HY-B0253S
Piroxicam D3 (CP-16171 D3) is deuterium labeledPiroxicam Piroxicam is a non-steroidalanti-inflammatory drugs acts as a COX inhibitorwith IC s of 47 25 μM for human monocyte COX-150
and COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Prim-O-glucosylcimifuginCat No HY-N0635
Prim-O-glucosylcimifugin exerts anti-inflammatoryeffects through the inhibition of and iNOS COX-2expression by through regulating JAK2STAT3signaling
Purity 9976Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Propyphenazone (4-Isopropylantipyrine Isopropylphenazone) Cat No HY-A0273
Propyphenazone is a pyrazolone derivative withanti-inflammatory analgesic and antipyreticactivity Propyphenazone-based analogues asprodrugs and selective cyclooxygenase-2inhibitors
Purity 9994Clinical Data LaunchedSize 10 mM times 1 mL 250 mg
PsoralidinCat No HY-N0232
Psoralidin isolated from the seed of Psoralea is a dual inhibitor of andcorylifolia COX-2
regulates ionizing radiation (IR)-induced5-LOXpulmonary inflammationAnti-canceranti-bacterial and anti-inflammatory properties
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg
Rebamipide (OPC12759 Proamipide) Cat No HY-B0360
Rebamipide (OPC12759) is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Rebamipide D4 (OPC12759 D4 Proamipide D4) Cat No HY-B0360S
Rebamipide D4 (OPC12759 D4) is deuterium labeledRebamipide Rebamipide is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Revaprazan hydrochlorideCat No HY-N7067
Revaprazan hydrochloride is a novel acid pumpantagonist ( ) Revaprazan hydrochlorideAPAreduces expression and has significantCOX-2anti-inflammatory actions activities in H pyloriinfection
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 13
RHC 80267 (U-57908) Cat No HY-107416
RHC 80267 (U-57908) is a potent and selectiveinhibitor of (withdiacylglycerol lipase (DAGL)
of 4 μM in canine platelets) RHC-80267IC50
inhibits activity with an of 4cholinesterase IC50
μM thereby enhancing the relaxation evoked byacetylcholine
Purity gt98Clinical Data No Development ReportedSize 10 mM1m 10 mg 25 mg 50 mg 100 mg
Roburic acidCat No HY-N0481
Roburic acid a tetracyclic triterpenoid found in acts as an inhibitor ofGentiana macrophylla
with s of 5 and 9 μM for COX-1 andCOX IC50
COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Rofecoxib (MK 966) Cat No HY-17372
Rofecoxib is a potent specific and orally active inhibitor with s of 26 and 18 nM forCOX-2 IC50
human COX-2 in human osteosarcoma cells andChinese hamster ovary cells with a 1000-foldselectivity for COX-2 over human COX-1 (IC gt50
50 μM in U937 cells and gt 15 μM inhellip
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Rutaecarpine (Rutecarpine) Cat No HY-N0147
Rutaecarpine an alkaloid of isEvodia rutaecarpaan inhibitor of with an value of 028COX-2 IC50
μM
Purity 9911Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
RWJ 63556Cat No HY-U00022
RWJ 63556 is an orally active COX-2 inhibitor withselective5-lipoxygenase
anti-inflammatory activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
S-(+)-Ketoprofen ((S)-Ketoprofen Dexketoprofen) Cat No HY-B2137
S-(+)-Ketoprofen is a potent inhibitor of both and with s of 19 and 27 nMCOX-1 COX-2 IC50
respectively
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
S-(+)-Marmesin ((+)-Marmesin (S)-Marmesin) Cat No HY-N2176
S-(+)-Marmesin is a natural coumarin exhibiting dual inhibitory activityCOX-25-LOX
Purity 9904Clinical Data No Development ReportedSize 2 mg 5 mg 10 mg 25 mg 50 mg
S-2474Cat No HY-19212
S-2474 is an inhibitor of and COX-2 5-lipoxygenase with s of 11 nM and 27 μM for COX-2(5-LO) IC50
and COX-1 in human intact cells and used as anonsteroidal anti-inflammatory drug
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Salicin (D-(minus)-Salicin Salicoside) Cat No HY-N0149
Salicin is a natural inhibitorCOX
Purity 9960Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
Salicylic acid (2-Hydroxybenzoic acid) Cat No HY-B0167
Salicylic acid inhibits cyclo-oxygenase-2 ( )COX-2activity independently of transcription factor(NF-κB) activation
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
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SC-560Cat No HY-59105
SC-560 is a potent and selective inhibitorCOX-1with an of 9 nMIC50
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SC57666Cat No HY-U00129
SC57666 is a selective inhibitor with anCOX2 of 26 nMIC50
Purity 9894Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 20 mg
SC58451Cat No HY-U00239
SC58451 is a potent and selective Cox-2inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Sodium Salicylate (Salicylic acid sodium salt
2-Hydroxybenzoic acid sodium salt) Cat No HY-B0167A
Sodium Salicylate inhibits cyclo-oxygenase-2( ) activity independently of transcriptionCOX-2factor (NF-κB) activation
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
Sulindac (MK-231) Cat No HY-B0008
Sulindac (MK-231) is a non-steroidalantiinflammatory agent acts as a COX-2inhibitor and inhibits overexpression of COX-2
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
SyringaldehydeCat No HY-N1390
Syringaldehyde is a polyphenolic compoundbelonging to the group of flavonoids and is foundin different plant species like Manihot
and esculenta Magnolia officinalisSyringaldehyde moderately inhibits activityCOX-2with an of 35 μgmLIC50
Purity 9996Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Tenidap (CP-66248) Cat No HY-105028
Tenidap a non-steroidal anti-inflammatory drugis a selective inhibitor with valuesCOX-1 IC50
of 003 microM and 12 microM for COX-1 and COX-2respectively Tenidap has anti-inflammatory andantirheumatic properties Tenidap is also aspecific SLC26A3 inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tenoxicam (Ro-12-0068) Cat No HY-B0440
Tenoxicam (Ro-12-0068) an antiinflammatory agentwith analgesic and antipyretic properties
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) Cat No HY-112731
TFAP is a selective cyclooxygenase-1 (COX-1)inhibitor with an of 08 μMIC50
Purity 9997Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Thioflosulide (L-745337) Cat No HY-19217
Thioflosulide (L-745337) is a selective inhibitor with an ofcyclooxygenase-2 (COX2) IC50
23 nM and shows anti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
wwwMedChemExpresscom 15
Tilmacoxib (JTE522 JTP19605 RWJ57504) Cat No HY-U00197
Tilmacoxib (JTE522) is a highly selectivetime-dependent and irreversible human COX-2inhibitor with an of 85 nM in an enzymeIC50
assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Timegadine (SR1368) Cat No HY-100125
Timegadine a new antiinflammatory agent is foundto be a potent competitive inhibitor of
( ) and withcyclo-oxygenase COX lipo-oxygenases ranging from 5 nM (washed rabbit platelets)IC50
to 20 μM (rat brain) for COX and 100 μM forlipo-oxygenase both in the cytosol fractionhellip
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tolfenamic Acid (GEA 6414) Cat No HY-B0335
Tolfenamic Acid (GEA 6414) is a non-steroidalanti-inflammatory and anti-cancer agentselectively inhibits with an of 1349COX-2 IC50
μM (353 μgmL) in LPS-treated (COX-2) canine DH82monocytemacrophage cells but shows no effect onCOX-1
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 10 g
Tolmetin sodium dihydrateCat No HY-B1489
Tolmetin sodium dihydrate is a non-steroidalantiinflammatory agent and acts as anon-selective inhibitorCOX
Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
TriflusalCat No HY-B0531
Triflusal irreversibly inhibits the production ofthromboxane-B2 in platelets by acetylatingcycloxygenase-1 Target COX Triflusal at 10 mM100 mM and 1 M decreases LDH efflux in rat brainslices after anoxiareoxygenation by 24 35 and49 respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Valdecoxib (SC 65872) Cat No HY-15762
Valdecoxib is a highly potent and selectiveinhibitor of with s of 5 nM and 140 μMCOX-2 IC50
for COX-2 and COX-1 respeceively Valdecoxib canbe used in the research of arthritis and pain
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Veratric acid (34-Dimethoxybenzoic acid) Cat No HY-N2007
Veratric acid (34-Dimethoxybenzoic acid) is anorally active phenolic compound derived fromvegetables and fruits has antioxidant andanti-inflammatory activities
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
XanthohumolCat No HY-N1067
Xanthohumol is one of the principal flavonoidsisolated from hops the inhibitor ofdiacylglycerol acetyltransferase ( ) DGAT COX-1and COX-2 and shows anti-cancer andanti-angiogenic activities
Purity 9968Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 25 mg
Zaltoprofen (CN100) Cat No HY-B0619
Zaltoprofen(CN100) is an inhibitor of COX fortreatment of arthritis
Purity 9909Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
[10]-ShogaolCat No HY-N2434
[10]-Shogaol is an antioxidant from Zingiber for human skin cell growth and aofficinale
migration enhancer [10]-Shogaol inhibits COX-2with an of 75 μM and has antiproliferationIC50
activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
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[8]-ShogaolCat No HY-N2435
-Shogaol one of the pungent phenolic compounds inginger exhibits anti-platelet activity ( =5IC50
μM) and inhibits COX-2 ( =175 μM) -ShogaolIC50
induces apoptosis in human leukemia cells
Purity 9918Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-Humulene (Humulene α-Caryophyllene) Cat No HY-N6968
α-Humulene is a main constituent of Tanacetum L (Asteraceae) essential oil withvulgare
anti-inflammation (IC =15plusmn2 microgmL) α-Humulene50
inhibits and expressionCOX-2 iNOS
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-ChaconineCat No HY-129113
α-Chaconine isolated from a Solanum L cv Jayoung inhibits thetuberosum
expressions of and atCOX-2 IL-1β IL-6 TNF-αthe transcriptional level
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 17
Diflunisal (MK-647) Cat No HY-18342
Diflunisal (MK-647) is a salicylate derivativewith nonsteroidal anti-inflammatory and uricosuricproperties which is used alone as an analgesicand in rheumatoid arthritis patients Themechanism of action of diflunisal is as aCyclooxygenase ( ) InhibitorCOX
Purity 9937Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Eicosatetraynoic acid (ETYA) Cat No HY-124108
Eicosatetraynoic acid (ETYA) is a nonspecificinhibitor of and ( =8cyclooxygenase lipoxygenase ID50
μM and 4 μM respectively) Eicosatetraynoic acid(ETYA) activates PPARα and PPARγ chimeras at 10microM
Purity gt98Clinical DataSize 1 mg
Esculentoside ACat No HY-N0632
Esculentoside A (EsA) a kind of triterpenesaponin isolated from roots of Phytolacca esculentaEsculentoside A (EsA) possesses anti-inflammatoryactivity in acute and chronic experimental modelshas selective inhibitory activity towardscyclooxygenase-2 ( )COX-2
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Ethyl CaffeateCat No HY-N6966
Ethyl Caffeate is a natural phenolic compoundisolated from Bidens pilosa
Purity 9891Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
Etodolac (AY-24236) Cat No HY-76251
Etodolac (AY-24236) is a non-steroidalanti-inflammatory compound that is a non-selectiveinhibitor of COX (IC =535 nM)50
Purity 9910Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
Etoricoxib (MK-0663 L-791456) Cat No HY-15321
Etoricoxib (MK-0663) is a non steroidalanti-inflammatory agent acting as a selective andorally active inhibitor with s of 11COX-2 IC50
μM and 116 μM for COX-2 and COX-1 in human wholeblood
Purity 9992Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Etoricoxib D4 (MK-0663 D4 L-791456 D4) Cat No HY-15321S
Etoricoxib D4 (MK-0663 D4) is a deuterium labeledEtoricoxib Etoricoxib is a non steroidalanti-inflammatory agent acting as a selective andorally active inhibitor with s of 11COX-2 IC50
μM and 116 μM for COX-2 and COX-1 in human wholeblood
Purity 9935Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg
Fenofibric acid (FNF acid) Cat No HY-B0760
Fenofibric acid an active metabolite offenofibrate is a activitor with s ofPPAR EC50
224 microM 147 microM and 106 microM for PPARα PPARγ andPPARδ respectively Fenofibric acid also inhibits
enzyme activity with an of 48 nMCOX-2 IC50
Purity 9938Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Fenoprofen CalciumCat No HY-B0288A
Fenoprofen Calcium is a nonsteroidalanti-inflammatory antiarthritic agent
Purity gt98Clinical Data LaunchedSize 500 mg 1 g 5 g
Fenoprofen Calcium hydrate (Fenoprofen calcium salt dihydrate) Cat No HY-B0288B
Fenoprofen Calcium hydrate is a nonsteroidalanti-inflammatory antiarthritic agent
Purity 9935Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
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Firocoxib (ML 1785713) Cat No HY-14670
Firocoxib(ML 1785713) is a potent and selectivecyclooxygenase (COX)-2 inhibitor with IC50 of 013uM 58 fold sensitivity for COX2 VSCOX1
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
FK 3311 (COX-2 Inhibitor V) Cat No HY-14445
FK 3311 (COX-2 Inhibitor V) is a selectiveinhibitor of with antiinflammatory agentCOX-2
Purity 9806Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
Flosulide (ZK 38997 CGP 28238) Cat No HY-U00083
Flosulide is a potent and selective COX-2inhibitor used for the treatment for inflammatorydiseases
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Flufenamic acidCat No HY-B1221
Flufenamic acid is a non-steroidalanti-inflammatory agent inhibits cyclooxygenase( ) activates and also modulates ionCOX AMPKchannels blocking and chloride channels L-type
modulating non-selective cationCa channels2+
channels ( ) activating NSC K channels+
Purity 9992Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Flunixin meglumineCat No HY-B0386
Flunixin Meglumine is a potent inhibitor of COXused as analgesic agent with anti-inflammatory andantipyretic activity Target COX Flunixinmeglumine is a potent non-narcotic non-steroidalanalgesic agent with anti-inflammatory andantipyretic activity
Purity 9965Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
FR-188582Cat No HY-U00146
FR-188582 is a highly selective inhibitor of ( )-2 with an value of 17cyclooxygenase COX IC50
nM
Purity 9921Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Gallic acid (345-Trihydroxybenzoic acid) Cat No HY-N0523
Gallic acid is an antioxidant which can inhibitboth COX-2
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Ginsenoside C-K (Ginsenoside compound K Ginsenoside K) Cat No HY-N0904
Ginsenoside C-K a bacterial metabolite of G-Rb1exhibits anti-inflammatory effects by reducing iNOSand Ginsenoside C-K exhibits an inhibitionCOX-2against the activity of and inCYP2C9 CYP2A6human liver microsomes with s of 320plusmn36 μMIC50
and 636plusmn42 μM respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ginsenoside Rb3 (Gypenoside IV) Cat No HY-N0041
Ginsenoside Rb3 is extracted from steamed Panax Ginsenoside Rb3 exhibits inhibitorynotoginseng
effect on TNFα-induced transcriptionalNF-κBactivity with an of 82 μM in 293T cellIC50
lines Ginsenoside Rb3 also inhibits the inductionof and mRNACOX-2 iNOS
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ginsenoside Rd (Gypenoside VIII) Cat No HY-N0043
Ginsenoside Rd inhibits TNFα-induced NF-κBtranscriptional activity with an ofIC50
1205plusmn082 μM in HepG2 cells Ginsenoside Rdinhibits expression of and mRNACOX-2 iNOSGinsenoside Rd also inhibits influxCa2+
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
wwwMedChemExpresscom 7
Ginsenoside Rg5Cat No HY-N0908
Ginsenoside Rg5 is the main component of Redginseng Ginsenoside blocks binding of to itsIGF-1receptor with an of ~90 nM Ginsenoside Rg5IC50
also inhibits the mRNA expression of viaCOX-2suppression of the DNA binding activities of
NF-κB p65
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
GnetolCat No HY-126052
Gnetol is a phenolic compound isolated from theroot of Brongn Gnetol potentlyGnetum ulainhibits ( of 078 μM) and COX-1 IC50 HDACGnetol is a potent inhibitor with antyrosinase
of 45 μM for murine tyrosinase andIC50
suppresses melanin biosynthesis
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Guaiacol (2-Methoxyphenol) Cat No HY-N1380
Guaiacol a phenolic compound isolated from Guaiacresin inhibits LPS-stimulated expressionCOX-2and activation Anti-inflammatory activityNF-κB
Purity 9929Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
GW-406381Cat No HY-119304
GW406381 a highly selective cyclooxygenase-2 inhibitor attenuates spontaneous ectopic(COX-2)
discharge in sural nerves of rats followingchronic constriction injury
Purity 9959Clinical DataSize 10 mM times 1 mL 1 mg
HamaudolCat No HY-N6891
Hamaudol is a chromone isolated from Saposhnikovia Hamaudol shows significant inhibitorydivaricata
activity on and cyclooxygenase (COX)-1 COX-2activities with values of 030 057 mMIC50
respectively and has potent analgesia andanti-inflammary effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
HarpagosideCat No HY-N0396
Harpagoside is isolated from Harpagophytum Harpagoside has inhibitory effectsprocumbens (Hp)
on and activity and inhibits NOCOX-1 COX-2production
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
HexahydrocurcuminCat No HY-N0929
Hexahydrocurcumin is a natural compound whichposesses anticancer and anti-inflammatoryactivities selective COX-2 inhibitor
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Ibuprofen ((plusmn)-Ibuprofen) Cat No HY-78131
Ibuprofen is an anti-inflammatory inhibitortargeting and with s of 13 μMCOX-1 COX-2 IC50
and 370 μM respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Ibuprofen D3 ((plusmn)-Ibuprofen D3) Cat No HY-78131S
Ibuprofen D3 is a deuterium labeled IbuprofenIbuprofen is a COX-1 and COX-2 inhibitor with IC s50
of 13 μM and 370 μM
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Iguratimod (T614) Cat No HY-17009
Iguratimod is an antirheumatic agent acts as aninhibitor of with an of 20 μM (77COX-2 IC50
μgmL) but shows no effect on COX-1 Iguratimodalso inhibits macrophage migration inhibitoryfactor ( ) with an of 681 μMMIF IC50
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
8 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Imrecoxib (BAP-909) Cat No HY-114200
Imrecoxib (BAP-909) is a novel and selectivecyclooxygenase 2 ( ) inhibitor with an COX-2 IC50
value of 18 nM it also inhibits COX1- activitywith an value of 115 nM Imrecoxib (BAP-909)IC50
has anti-inflammatory effect
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 50 mg 100 mg
Indobufen (Ibustrin) Cat No HY-18763
Indobufen is a platelet aggregation inhibitorIndobufen is a reversible platelet cyclooxygenase( ) activity inhibitor Indobufen suppressesCoxthromboxane A (TxA ) synthesis Indobufen2 2
down-regulates tissue factor (TF) in monocytes
Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Indomethacin (Indometacin) Cat No HY-14397
Indomethacin is a potent and nonselectiveinhibitor of and with s of 18 nMCOX1 COX2 IC50
and 26 nM for human COX-1 and COX-2 respectivelyin CHO cells
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Inulicin (1-O-Acetylbritannilactone) Cat No HY-N0896
Inulicin (1-O-Acetylbritannilactone) is an activecompound isolated from InulicinInula Britannica L(1-O-Acetylbritannilactone) inhibits VEGF-mediatedactivation of and Src FAK
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Isoorientin (Homoorientin) Cat No HY-N0767
Isoorientin is a potent inhibitor of withCOX-2an value of 39 μMIC50
Purity 9924Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 25 mg 50 mg
JaceosidinCat No HY-N0831
Jaceosidin is a flavonoid isolated from induces apoptosis in cancerArtemisia vestita
cells activates and down-regulates Mcl-1 andBaxc-FLIP expression
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 25 mg
Ketoprofen (RP-19583) Cat No HY-B0227
Ketoprofen (RP-19583) is a non-steroidalantiinflammatory agent acting as a potentinhibitor of with s of 2 nM and 26 nMCOX IC50
for COX-1 and COX-2 in human blood monocytesrespectively
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Ketorolac (RS37619) Cat No HY-B0580
Ketorolac is a non-steroidal anti-inflammatoryagent acting as a nonselective inhibitorCOXwith s of 20 nM for COX-1 and 120 nM forIC50
COX-2
Purity gt98Clinical Data LaunchedSize 100 mg 500 mg
Ketorolac D5Cat No HY-B0580S
Ketorolac D5 is a deuterium labeled KetorolacKetorolac is a non-steroidal anti-inflammatoryagent acting as a nonselective inhibitorCOXwith s of 20 nM for COX-1 and 120 nM forIC50
COX-2
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ketorolac tromethamine salt (Ketorolac Tromethamine
Ketorolac tris salt RS37619 tromethamine salt) Cat No HY-B0138
Ketorolac tromethamine salt (RS37619 tromethaminesalt) is a non-steroidal anti-inflammatory agentacting as a nonselective inhibitor withCOX
s of 20 nM for COX-1 and 120 nM for COX-2IC50
Purity 9994Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
wwwMedChemExpresscom 9
Licofelone (ML-3000) Cat No HY-B1452
Licofelone (ML-3000) is a dual COX5-lipoxygenase inhibitor ( =021018 μM(5-LOX) IC50
respectively) for the treatment of osteoarthritisLicofelone exerts anti-inflammatory andanti-proliferative effects
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
Lornoxicam (Chlortenoxicam Ro 13-9297 TS110) Cat No HY-B0367
Lornoxicam a COX-1 and COX-2 inhibitor is a newnonsteroidal anti-inflammatory drug (NSAID)Target COX Lornoxicam showed a balancedinhibition of COX-1-2 exhibiting the lowest IC50(0005 microM0008 microM) of the large panel ofNSAIDs tested
Purity 9831Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
LoxoprofenCat No HY-B0578
Loxoprofen is a non-steroidal anti-inflammatorydrug Target COX Loxoprofen is a non-steroidalanti-inflammatory drug in the propionic acidderivatives group which also includes ibuprofenand naproxen among others
Purity 9882Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
LY 178002Cat No HY-101579
LY 178002 is a potent inhibitor of 5-lipoxygenase with of 06 μM(5-LPO) phospholipase A2 IC50
for 5-lipoxygenase inhibits cellular productionof LTB4 by human polymorphonuclear leukocytes andshows relatively weak inhibition on cyclooxygenase
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
MavacoxibCat No HY-119447
Mavacoxib is a selective oral long-acting inhibitor and acyclooxygenase-2 (COX-2)
long-acting non-steroidal anti-inflammatory drug(NSAID) Mavacoxib is used to treat pain andinflammation associated with degenerative jointdisease in dogs
Purity 9983Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Mefenamic acidCat No HY-B0574
Mefenamic acid is a non-steroidalanti-inflammatory agent acting as a competitiveinhibitor of and with s of 40hCOX-1 hCOX-2 IC50
nM and 3 μM for hCOX-1 and hCOX-2 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
MeloxicamCat No HY-B0261
Meloxicam is a non-steroidal antiinflammatoryagent inhibits activity with s of 049COX IC50
microM and 366 microM for COX-2 and COX-1 respectively
Purity 9807Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Meloxicam D4Cat No HY-B0261S
Meloxicam D4 is deuterium labeled MeloxicamMeloxicam is a non-steroidal antiinflammatoryagent inhibits COX activity with IC s of 049 microM50
and 366 microM for COX-2 and COX-1 respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Metamizole sodium hydrateCat No HY-B1279
Metamizole sodium hydrate is a potent analgesicdrug that has been demonstrated to inhibitcyclooxygenase (COX)
Purity gt980Clinical Data LaunchedSize 500 mg
Methyl Salicylate (Wintergreen oil) Cat No HY-Y0189
Methyl Salicylate (Wintergreen oil) is a topicalanalgesic and anti-inflammatory agent Also usedas a pesticide a denaturant a fragranceingredient and a flavoring agent in food andtobacco products A systemic acquired resistance(SAR) signal in tobacco
Purity 9998Clinical Data No Development ReportedSize 10 mM times 1 mL 50 mg
10 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
N-trans-Feruloyltyramine (N-feruloyltyramine Moupinamide) Cat No HY-N2410
N-trans-Feruloyltyramine (N-feruloyltyramine) analkaloid from is an inhibitor of Piper nigru COX1and with potential antioxidant propertiesCOX2N-trans-Feruloyltyramine possessesanti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
Nabumetone (BRL14777) Cat No HY-B0559
Nabumetone is an orally active non-acidicanti-inflammatory agent acts as a potent andselective inhibitor and is the prodrug ofCOX-2the active metabolite 6MNA
Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Naproxen ((S)-Naproxen) Cat No HY-15030
Naproxen is a and inhibitor withCOX-1 COX-2s of 872 and 515 μM respectively in cellIC50
assay
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Naproxen etemesil (LT-NS 001 MX 1094) Cat No HY-19675
Naproxen etemesil is a lipophilic non-acidicinactive prodrug of naproxen that is hydrolysed topharmacologically active Naproxen once absorbedNaproxen is a and inhibitor withCOX-1 COX-2
s of 872 and 515 μM respectively in cellIC50
assay
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Naproxen sodiumCat No HY-15030A
Naproxen sodium is a and inhibitorCOX-1 COX-2with s of 872 and 515 μM respectively inIC50
cell assay
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) Cat No HY-N0722
Neochlorogenic acid is a natural polyphenoliccompound found in dried fruits and other plantsNeochlorogenic acid inhibits the production of
and Neochlorogenic acid suppressesTNF-α IL-1β protein expressioniNOS and COX-2
Purity 9946Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Nepafenac (AHR 9434 AL 6515) Cat No HY-17357
Nepafenac(AHR 9434 AL 6515 Nevanac) is aselective COX-2 inhibitor is prodrug of AmfenacIC50 value Target COX-2 Nepafenac is a NSAID(nonsteroidal anti inflammatory drug) that isroutinely used in opthamology to control painfollowing cataract surgery
Purity 9514Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Nepafenac D5 (AHR-9434 D5 AL-6515 D5) Cat No HY-17357S
Nepafenac D5 is the deuterium labeled Nepafenacwhich is a selective COX-2 inhibitor
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Nimesulide (R805) Cat No HY-B0363
Nimesulide is a selective inhibitor withCOX-2s of 70 nM-70 μM in a time-dependent mannerIC50
but it shows no effect on COX-1 (IC gt100 μM)50
Nimesulide has potent anti-inflammatory analgesicand antipyretic properties
Purity 9991Clinical Data Phase 4Size 10 mM times 1 mL 100 mg 500 mg
Nimesulide D5Cat No HY-B0363S
Nimesulide D5 is a deuterium labeled NimesulideNimesulide is a selective inhibitor withCOX-2
s of 70 nM-70 μM in a time-dependent mannerIC50
but it shows no effect on COX-1 (IC gt100 μM)50
Nimesulide has potent anti-inflammatory analgesicand antipyretic properties
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 11
Nitroaspirin (NCX 4016) Cat No HY-123823
Nitroaspirin (NCX 4016) is a nitric oxide (NO)donor and a nitro-derivative of Aspirin whichcombines with Nitroaspirin to inhibitcyclooxygenase
Purity gt98Clinical DataSize 1 mg 5 mg
Nitroflurbiprofen (HCT 1206 NO-flurbiprofen Nitroxybutyl flurbiprofen) Cat No HY-U00013
Nitroflurbiprofen is a ( )cyclooxygenase COXinhibitor with nitric oxide (NO)-donatingproperties modulates the increased intrahepaticvascular tone in portal hypertensive cirrhoticrats
Purity 9964Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
NS-398Cat No HY-13913
NS-398 is a non-steroidal an-inflammatory agentwith analgesic and antipyretic effects andselectively inhibits prostaglandin GH synthase2cyclooxygenase 2 ( ) activity with an COX-2 IC50
of 38 μM and has no effect on COX-1 at 100 μM
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Oxaprozin (Oxaprozinum Wy21743) Cat No HY-B0808
Oxaprozin is an inhibitor of both andCOX-1 with s of 22 μM and 36 μM for humanCOX-2 IC50
platelet COX-1 and IL-1-stimulated human synovialcell COX-2 respectively Oxaprozin also inhibitsthe activation of NF-κB
Purity 9963Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Oxaprozin D4 (Wy-21743 D4) Cat No HY-B0808S
Oxaprozin D4 is the deuterium labeled Oxaprozinwhich is a non-steroidal anti-inflammatory drug(NSAID)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
Pamicogrel (KBT3022) Cat No HY-U00175
Pamicogrel (KBT3022) is a ( )cyclooxygenase COXinhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Paradol ([6]-Gingerone [6]-Paradol) Cat No HY-14617
Paradol is a pungent phenolic substance found inginger and other Zingiberaceae plants Paradol isan effective inhibitor of tumor promotion in mouseskin carcinogenesis binds to cyclooxygenase
active site(COX)-2
Purity 9988Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Parecoxib (SC 69124) Cat No HY-17474
Parecoxib is a potent and selective COX-2inhibitor IC50 value Target COX-2 in vitro Theprodrug Parecoxib as well as its active metaboliteval have a specific affinity to the cannabinoid(CB) receptor measured in CB1-expressing HEK 293cells and rat brain tissue
Purity 9932Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Parecoxib Sodium (SC 69124A) Cat No HY-17474A
Parecoxib Sodium (SC 69124A) is a potent andselective COX-2 inhibitor
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
PelubiprofenCat No HY-12383
Pelubiprofen an orally active and non-steroidalanti-inflammatory drug is a member of the2-arylpropionic acid family and has relativelyselective effects on activityCOX-2
Purity gt98Clinical Data No Development ReportedSize 100 mg 250 mg 500 mg
12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Phenacetin (Acetophenetidin) Cat No HY-B0476
Phenacetin is a non-opioid analgesic withoutanti-inflammatory properties inhibits COX-3activity Target COX Phenacetin is apain-relieving and fever-reducing drug Phenacetinwas withdrawn from the Canadian market in June1973 due to concerns regarding nephropathy
Purity 9909Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
PhenylbutazoneCat No HY-B0230
Phenylbutazone is used as a non-steroidalanti-inflammatory agent for the treatment ofchronic pain including the symptoms of arthritisTarget Others Phenylbutazone was originally madeavailable for use in humans for the treatment ofrheumatoid arthritis and gout in 1949
Purity 9886Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg
Piroxicam (CP-16171) Cat No HY-B0253
Piroxicam (CP-16171) is a non-steroidalanti-inflammatory drugs acts as a inhibitorCOXwith s of 47 25 μM for human monocyte COX-1IC50
and COX-2 respectively
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g 10 g
Piroxicam D3 (CP-16171 D3) Cat No HY-B0253S
Piroxicam D3 (CP-16171 D3) is deuterium labeledPiroxicam Piroxicam is a non-steroidalanti-inflammatory drugs acts as a COX inhibitorwith IC s of 47 25 μM for human monocyte COX-150
and COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Prim-O-glucosylcimifuginCat No HY-N0635
Prim-O-glucosylcimifugin exerts anti-inflammatoryeffects through the inhibition of and iNOS COX-2expression by through regulating JAK2STAT3signaling
Purity 9976Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Propyphenazone (4-Isopropylantipyrine Isopropylphenazone) Cat No HY-A0273
Propyphenazone is a pyrazolone derivative withanti-inflammatory analgesic and antipyreticactivity Propyphenazone-based analogues asprodrugs and selective cyclooxygenase-2inhibitors
Purity 9994Clinical Data LaunchedSize 10 mM times 1 mL 250 mg
PsoralidinCat No HY-N0232
Psoralidin isolated from the seed of Psoralea is a dual inhibitor of andcorylifolia COX-2
regulates ionizing radiation (IR)-induced5-LOXpulmonary inflammationAnti-canceranti-bacterial and anti-inflammatory properties
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg
Rebamipide (OPC12759 Proamipide) Cat No HY-B0360
Rebamipide (OPC12759) is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Rebamipide D4 (OPC12759 D4 Proamipide D4) Cat No HY-B0360S
Rebamipide D4 (OPC12759 D4) is deuterium labeledRebamipide Rebamipide is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Revaprazan hydrochlorideCat No HY-N7067
Revaprazan hydrochloride is a novel acid pumpantagonist ( ) Revaprazan hydrochlorideAPAreduces expression and has significantCOX-2anti-inflammatory actions activities in H pyloriinfection
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 13
RHC 80267 (U-57908) Cat No HY-107416
RHC 80267 (U-57908) is a potent and selectiveinhibitor of (withdiacylglycerol lipase (DAGL)
of 4 μM in canine platelets) RHC-80267IC50
inhibits activity with an of 4cholinesterase IC50
μM thereby enhancing the relaxation evoked byacetylcholine
Purity gt98Clinical Data No Development ReportedSize 10 mM1m 10 mg 25 mg 50 mg 100 mg
Roburic acidCat No HY-N0481
Roburic acid a tetracyclic triterpenoid found in acts as an inhibitor ofGentiana macrophylla
with s of 5 and 9 μM for COX-1 andCOX IC50
COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Rofecoxib (MK 966) Cat No HY-17372
Rofecoxib is a potent specific and orally active inhibitor with s of 26 and 18 nM forCOX-2 IC50
human COX-2 in human osteosarcoma cells andChinese hamster ovary cells with a 1000-foldselectivity for COX-2 over human COX-1 (IC gt50
50 μM in U937 cells and gt 15 μM inhellip
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Rutaecarpine (Rutecarpine) Cat No HY-N0147
Rutaecarpine an alkaloid of isEvodia rutaecarpaan inhibitor of with an value of 028COX-2 IC50
μM
Purity 9911Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
RWJ 63556Cat No HY-U00022
RWJ 63556 is an orally active COX-2 inhibitor withselective5-lipoxygenase
anti-inflammatory activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
S-(+)-Ketoprofen ((S)-Ketoprofen Dexketoprofen) Cat No HY-B2137
S-(+)-Ketoprofen is a potent inhibitor of both and with s of 19 and 27 nMCOX-1 COX-2 IC50
respectively
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
S-(+)-Marmesin ((+)-Marmesin (S)-Marmesin) Cat No HY-N2176
S-(+)-Marmesin is a natural coumarin exhibiting dual inhibitory activityCOX-25-LOX
Purity 9904Clinical Data No Development ReportedSize 2 mg 5 mg 10 mg 25 mg 50 mg
S-2474Cat No HY-19212
S-2474 is an inhibitor of and COX-2 5-lipoxygenase with s of 11 nM and 27 μM for COX-2(5-LO) IC50
and COX-1 in human intact cells and used as anonsteroidal anti-inflammatory drug
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Salicin (D-(minus)-Salicin Salicoside) Cat No HY-N0149
Salicin is a natural inhibitorCOX
Purity 9960Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
Salicylic acid (2-Hydroxybenzoic acid) Cat No HY-B0167
Salicylic acid inhibits cyclo-oxygenase-2 ( )COX-2activity independently of transcription factor(NF-κB) activation
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
14 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SC-560Cat No HY-59105
SC-560 is a potent and selective inhibitorCOX-1with an of 9 nMIC50
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SC57666Cat No HY-U00129
SC57666 is a selective inhibitor with anCOX2 of 26 nMIC50
Purity 9894Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 20 mg
SC58451Cat No HY-U00239
SC58451 is a potent and selective Cox-2inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Sodium Salicylate (Salicylic acid sodium salt
2-Hydroxybenzoic acid sodium salt) Cat No HY-B0167A
Sodium Salicylate inhibits cyclo-oxygenase-2( ) activity independently of transcriptionCOX-2factor (NF-κB) activation
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
Sulindac (MK-231) Cat No HY-B0008
Sulindac (MK-231) is a non-steroidalantiinflammatory agent acts as a COX-2inhibitor and inhibits overexpression of COX-2
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
SyringaldehydeCat No HY-N1390
Syringaldehyde is a polyphenolic compoundbelonging to the group of flavonoids and is foundin different plant species like Manihot
and esculenta Magnolia officinalisSyringaldehyde moderately inhibits activityCOX-2with an of 35 μgmLIC50
Purity 9996Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Tenidap (CP-66248) Cat No HY-105028
Tenidap a non-steroidal anti-inflammatory drugis a selective inhibitor with valuesCOX-1 IC50
of 003 microM and 12 microM for COX-1 and COX-2respectively Tenidap has anti-inflammatory andantirheumatic properties Tenidap is also aspecific SLC26A3 inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tenoxicam (Ro-12-0068) Cat No HY-B0440
Tenoxicam (Ro-12-0068) an antiinflammatory agentwith analgesic and antipyretic properties
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) Cat No HY-112731
TFAP is a selective cyclooxygenase-1 (COX-1)inhibitor with an of 08 μMIC50
Purity 9997Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Thioflosulide (L-745337) Cat No HY-19217
Thioflosulide (L-745337) is a selective inhibitor with an ofcyclooxygenase-2 (COX2) IC50
23 nM and shows anti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
wwwMedChemExpresscom 15
Tilmacoxib (JTE522 JTP19605 RWJ57504) Cat No HY-U00197
Tilmacoxib (JTE522) is a highly selectivetime-dependent and irreversible human COX-2inhibitor with an of 85 nM in an enzymeIC50
assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Timegadine (SR1368) Cat No HY-100125
Timegadine a new antiinflammatory agent is foundto be a potent competitive inhibitor of
( ) and withcyclo-oxygenase COX lipo-oxygenases ranging from 5 nM (washed rabbit platelets)IC50
to 20 μM (rat brain) for COX and 100 μM forlipo-oxygenase both in the cytosol fractionhellip
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tolfenamic Acid (GEA 6414) Cat No HY-B0335
Tolfenamic Acid (GEA 6414) is a non-steroidalanti-inflammatory and anti-cancer agentselectively inhibits with an of 1349COX-2 IC50
μM (353 μgmL) in LPS-treated (COX-2) canine DH82monocytemacrophage cells but shows no effect onCOX-1
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 10 g
Tolmetin sodium dihydrateCat No HY-B1489
Tolmetin sodium dihydrate is a non-steroidalantiinflammatory agent and acts as anon-selective inhibitorCOX
Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
TriflusalCat No HY-B0531
Triflusal irreversibly inhibits the production ofthromboxane-B2 in platelets by acetylatingcycloxygenase-1 Target COX Triflusal at 10 mM100 mM and 1 M decreases LDH efflux in rat brainslices after anoxiareoxygenation by 24 35 and49 respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Valdecoxib (SC 65872) Cat No HY-15762
Valdecoxib is a highly potent and selectiveinhibitor of with s of 5 nM and 140 μMCOX-2 IC50
for COX-2 and COX-1 respeceively Valdecoxib canbe used in the research of arthritis and pain
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Veratric acid (34-Dimethoxybenzoic acid) Cat No HY-N2007
Veratric acid (34-Dimethoxybenzoic acid) is anorally active phenolic compound derived fromvegetables and fruits has antioxidant andanti-inflammatory activities
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
XanthohumolCat No HY-N1067
Xanthohumol is one of the principal flavonoidsisolated from hops the inhibitor ofdiacylglycerol acetyltransferase ( ) DGAT COX-1and COX-2 and shows anti-cancer andanti-angiogenic activities
Purity 9968Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 25 mg
Zaltoprofen (CN100) Cat No HY-B0619
Zaltoprofen(CN100) is an inhibitor of COX fortreatment of arthritis
Purity 9909Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
[10]-ShogaolCat No HY-N2434
[10]-Shogaol is an antioxidant from Zingiber for human skin cell growth and aofficinale
migration enhancer [10]-Shogaol inhibits COX-2with an of 75 μM and has antiproliferationIC50
activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
16 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
[8]-ShogaolCat No HY-N2435
-Shogaol one of the pungent phenolic compounds inginger exhibits anti-platelet activity ( =5IC50
μM) and inhibits COX-2 ( =175 μM) -ShogaolIC50
induces apoptosis in human leukemia cells
Purity 9918Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-Humulene (Humulene α-Caryophyllene) Cat No HY-N6968
α-Humulene is a main constituent of Tanacetum L (Asteraceae) essential oil withvulgare
anti-inflammation (IC =15plusmn2 microgmL) α-Humulene50
inhibits and expressionCOX-2 iNOS
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-ChaconineCat No HY-129113
α-Chaconine isolated from a Solanum L cv Jayoung inhibits thetuberosum
expressions of and atCOX-2 IL-1β IL-6 TNF-αthe transcriptional level
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 17
Firocoxib (ML 1785713) Cat No HY-14670
Firocoxib(ML 1785713) is a potent and selectivecyclooxygenase (COX)-2 inhibitor with IC50 of 013uM 58 fold sensitivity for COX2 VSCOX1
Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
FK 3311 (COX-2 Inhibitor V) Cat No HY-14445
FK 3311 (COX-2 Inhibitor V) is a selectiveinhibitor of with antiinflammatory agentCOX-2
Purity 9806Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
Flosulide (ZK 38997 CGP 28238) Cat No HY-U00083
Flosulide is a potent and selective COX-2inhibitor used for the treatment for inflammatorydiseases
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Flufenamic acidCat No HY-B1221
Flufenamic acid is a non-steroidalanti-inflammatory agent inhibits cyclooxygenase( ) activates and also modulates ionCOX AMPKchannels blocking and chloride channels L-type
modulating non-selective cationCa channels2+
channels ( ) activating NSC K channels+
Purity 9992Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Flunixin meglumineCat No HY-B0386
Flunixin Meglumine is a potent inhibitor of COXused as analgesic agent with anti-inflammatory andantipyretic activity Target COX Flunixinmeglumine is a potent non-narcotic non-steroidalanalgesic agent with anti-inflammatory andantipyretic activity
Purity 9965Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
FR-188582Cat No HY-U00146
FR-188582 is a highly selective inhibitor of ( )-2 with an value of 17cyclooxygenase COX IC50
nM
Purity 9921Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Gallic acid (345-Trihydroxybenzoic acid) Cat No HY-N0523
Gallic acid is an antioxidant which can inhibitboth COX-2
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Ginsenoside C-K (Ginsenoside compound K Ginsenoside K) Cat No HY-N0904
Ginsenoside C-K a bacterial metabolite of G-Rb1exhibits anti-inflammatory effects by reducing iNOSand Ginsenoside C-K exhibits an inhibitionCOX-2against the activity of and inCYP2C9 CYP2A6human liver microsomes with s of 320plusmn36 μMIC50
and 636plusmn42 μM respectively
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ginsenoside Rb3 (Gypenoside IV) Cat No HY-N0041
Ginsenoside Rb3 is extracted from steamed Panax Ginsenoside Rb3 exhibits inhibitorynotoginseng
effect on TNFα-induced transcriptionalNF-κBactivity with an of 82 μM in 293T cellIC50
lines Ginsenoside Rb3 also inhibits the inductionof and mRNACOX-2 iNOS
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Ginsenoside Rd (Gypenoside VIII) Cat No HY-N0043
Ginsenoside Rd inhibits TNFα-induced NF-κBtranscriptional activity with an ofIC50
1205plusmn082 μM in HepG2 cells Ginsenoside Rdinhibits expression of and mRNACOX-2 iNOSGinsenoside Rd also inhibits influxCa2+
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
wwwMedChemExpresscom 7
Ginsenoside Rg5Cat No HY-N0908
Ginsenoside Rg5 is the main component of Redginseng Ginsenoside blocks binding of to itsIGF-1receptor with an of ~90 nM Ginsenoside Rg5IC50
also inhibits the mRNA expression of viaCOX-2suppression of the DNA binding activities of
NF-κB p65
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
GnetolCat No HY-126052
Gnetol is a phenolic compound isolated from theroot of Brongn Gnetol potentlyGnetum ulainhibits ( of 078 μM) and COX-1 IC50 HDACGnetol is a potent inhibitor with antyrosinase
of 45 μM for murine tyrosinase andIC50
suppresses melanin biosynthesis
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Guaiacol (2-Methoxyphenol) Cat No HY-N1380
Guaiacol a phenolic compound isolated from Guaiacresin inhibits LPS-stimulated expressionCOX-2and activation Anti-inflammatory activityNF-κB
Purity 9929Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
GW-406381Cat No HY-119304
GW406381 a highly selective cyclooxygenase-2 inhibitor attenuates spontaneous ectopic(COX-2)
discharge in sural nerves of rats followingchronic constriction injury
Purity 9959Clinical DataSize 10 mM times 1 mL 1 mg
HamaudolCat No HY-N6891
Hamaudol is a chromone isolated from Saposhnikovia Hamaudol shows significant inhibitorydivaricata
activity on and cyclooxygenase (COX)-1 COX-2activities with values of 030 057 mMIC50
respectively and has potent analgesia andanti-inflammary effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
HarpagosideCat No HY-N0396
Harpagoside is isolated from Harpagophytum Harpagoside has inhibitory effectsprocumbens (Hp)
on and activity and inhibits NOCOX-1 COX-2production
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
HexahydrocurcuminCat No HY-N0929
Hexahydrocurcumin is a natural compound whichposesses anticancer and anti-inflammatoryactivities selective COX-2 inhibitor
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Ibuprofen ((plusmn)-Ibuprofen) Cat No HY-78131
Ibuprofen is an anti-inflammatory inhibitortargeting and with s of 13 μMCOX-1 COX-2 IC50
and 370 μM respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Ibuprofen D3 ((plusmn)-Ibuprofen D3) Cat No HY-78131S
Ibuprofen D3 is a deuterium labeled IbuprofenIbuprofen is a COX-1 and COX-2 inhibitor with IC s50
of 13 μM and 370 μM
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Iguratimod (T614) Cat No HY-17009
Iguratimod is an antirheumatic agent acts as aninhibitor of with an of 20 μM (77COX-2 IC50
μgmL) but shows no effect on COX-1 Iguratimodalso inhibits macrophage migration inhibitoryfactor ( ) with an of 681 μMMIF IC50
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
8 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Imrecoxib (BAP-909) Cat No HY-114200
Imrecoxib (BAP-909) is a novel and selectivecyclooxygenase 2 ( ) inhibitor with an COX-2 IC50
value of 18 nM it also inhibits COX1- activitywith an value of 115 nM Imrecoxib (BAP-909)IC50
has anti-inflammatory effect
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 50 mg 100 mg
Indobufen (Ibustrin) Cat No HY-18763
Indobufen is a platelet aggregation inhibitorIndobufen is a reversible platelet cyclooxygenase( ) activity inhibitor Indobufen suppressesCoxthromboxane A (TxA ) synthesis Indobufen2 2
down-regulates tissue factor (TF) in monocytes
Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Indomethacin (Indometacin) Cat No HY-14397
Indomethacin is a potent and nonselectiveinhibitor of and with s of 18 nMCOX1 COX2 IC50
and 26 nM for human COX-1 and COX-2 respectivelyin CHO cells
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Inulicin (1-O-Acetylbritannilactone) Cat No HY-N0896
Inulicin (1-O-Acetylbritannilactone) is an activecompound isolated from InulicinInula Britannica L(1-O-Acetylbritannilactone) inhibits VEGF-mediatedactivation of and Src FAK
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Isoorientin (Homoorientin) Cat No HY-N0767
Isoorientin is a potent inhibitor of withCOX-2an value of 39 μMIC50
Purity 9924Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 25 mg 50 mg
JaceosidinCat No HY-N0831
Jaceosidin is a flavonoid isolated from induces apoptosis in cancerArtemisia vestita
cells activates and down-regulates Mcl-1 andBaxc-FLIP expression
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 25 mg
Ketoprofen (RP-19583) Cat No HY-B0227
Ketoprofen (RP-19583) is a non-steroidalantiinflammatory agent acting as a potentinhibitor of with s of 2 nM and 26 nMCOX IC50
for COX-1 and COX-2 in human blood monocytesrespectively
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Ketorolac (RS37619) Cat No HY-B0580
Ketorolac is a non-steroidal anti-inflammatoryagent acting as a nonselective inhibitorCOXwith s of 20 nM for COX-1 and 120 nM forIC50
COX-2
Purity gt98Clinical Data LaunchedSize 100 mg 500 mg
Ketorolac D5Cat No HY-B0580S
Ketorolac D5 is a deuterium labeled KetorolacKetorolac is a non-steroidal anti-inflammatoryagent acting as a nonselective inhibitorCOXwith s of 20 nM for COX-1 and 120 nM forIC50
COX-2
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ketorolac tromethamine salt (Ketorolac Tromethamine
Ketorolac tris salt RS37619 tromethamine salt) Cat No HY-B0138
Ketorolac tromethamine salt (RS37619 tromethaminesalt) is a non-steroidal anti-inflammatory agentacting as a nonselective inhibitor withCOX
s of 20 nM for COX-1 and 120 nM for COX-2IC50
Purity 9994Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
wwwMedChemExpresscom 9
Licofelone (ML-3000) Cat No HY-B1452
Licofelone (ML-3000) is a dual COX5-lipoxygenase inhibitor ( =021018 μM(5-LOX) IC50
respectively) for the treatment of osteoarthritisLicofelone exerts anti-inflammatory andanti-proliferative effects
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
Lornoxicam (Chlortenoxicam Ro 13-9297 TS110) Cat No HY-B0367
Lornoxicam a COX-1 and COX-2 inhibitor is a newnonsteroidal anti-inflammatory drug (NSAID)Target COX Lornoxicam showed a balancedinhibition of COX-1-2 exhibiting the lowest IC50(0005 microM0008 microM) of the large panel ofNSAIDs tested
Purity 9831Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
LoxoprofenCat No HY-B0578
Loxoprofen is a non-steroidal anti-inflammatorydrug Target COX Loxoprofen is a non-steroidalanti-inflammatory drug in the propionic acidderivatives group which also includes ibuprofenand naproxen among others
Purity 9882Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
LY 178002Cat No HY-101579
LY 178002 is a potent inhibitor of 5-lipoxygenase with of 06 μM(5-LPO) phospholipase A2 IC50
for 5-lipoxygenase inhibits cellular productionof LTB4 by human polymorphonuclear leukocytes andshows relatively weak inhibition on cyclooxygenase
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
MavacoxibCat No HY-119447
Mavacoxib is a selective oral long-acting inhibitor and acyclooxygenase-2 (COX-2)
long-acting non-steroidal anti-inflammatory drug(NSAID) Mavacoxib is used to treat pain andinflammation associated with degenerative jointdisease in dogs
Purity 9983Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Mefenamic acidCat No HY-B0574
Mefenamic acid is a non-steroidalanti-inflammatory agent acting as a competitiveinhibitor of and with s of 40hCOX-1 hCOX-2 IC50
nM and 3 μM for hCOX-1 and hCOX-2 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
MeloxicamCat No HY-B0261
Meloxicam is a non-steroidal antiinflammatoryagent inhibits activity with s of 049COX IC50
microM and 366 microM for COX-2 and COX-1 respectively
Purity 9807Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Meloxicam D4Cat No HY-B0261S
Meloxicam D4 is deuterium labeled MeloxicamMeloxicam is a non-steroidal antiinflammatoryagent inhibits COX activity with IC s of 049 microM50
and 366 microM for COX-2 and COX-1 respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Metamizole sodium hydrateCat No HY-B1279
Metamizole sodium hydrate is a potent analgesicdrug that has been demonstrated to inhibitcyclooxygenase (COX)
Purity gt980Clinical Data LaunchedSize 500 mg
Methyl Salicylate (Wintergreen oil) Cat No HY-Y0189
Methyl Salicylate (Wintergreen oil) is a topicalanalgesic and anti-inflammatory agent Also usedas a pesticide a denaturant a fragranceingredient and a flavoring agent in food andtobacco products A systemic acquired resistance(SAR) signal in tobacco
Purity 9998Clinical Data No Development ReportedSize 10 mM times 1 mL 50 mg
10 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
N-trans-Feruloyltyramine (N-feruloyltyramine Moupinamide) Cat No HY-N2410
N-trans-Feruloyltyramine (N-feruloyltyramine) analkaloid from is an inhibitor of Piper nigru COX1and with potential antioxidant propertiesCOX2N-trans-Feruloyltyramine possessesanti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
Nabumetone (BRL14777) Cat No HY-B0559
Nabumetone is an orally active non-acidicanti-inflammatory agent acts as a potent andselective inhibitor and is the prodrug ofCOX-2the active metabolite 6MNA
Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Naproxen ((S)-Naproxen) Cat No HY-15030
Naproxen is a and inhibitor withCOX-1 COX-2s of 872 and 515 μM respectively in cellIC50
assay
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Naproxen etemesil (LT-NS 001 MX 1094) Cat No HY-19675
Naproxen etemesil is a lipophilic non-acidicinactive prodrug of naproxen that is hydrolysed topharmacologically active Naproxen once absorbedNaproxen is a and inhibitor withCOX-1 COX-2
s of 872 and 515 μM respectively in cellIC50
assay
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Naproxen sodiumCat No HY-15030A
Naproxen sodium is a and inhibitorCOX-1 COX-2with s of 872 and 515 μM respectively inIC50
cell assay
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) Cat No HY-N0722
Neochlorogenic acid is a natural polyphenoliccompound found in dried fruits and other plantsNeochlorogenic acid inhibits the production of
and Neochlorogenic acid suppressesTNF-α IL-1β protein expressioniNOS and COX-2
Purity 9946Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Nepafenac (AHR 9434 AL 6515) Cat No HY-17357
Nepafenac(AHR 9434 AL 6515 Nevanac) is aselective COX-2 inhibitor is prodrug of AmfenacIC50 value Target COX-2 Nepafenac is a NSAID(nonsteroidal anti inflammatory drug) that isroutinely used in opthamology to control painfollowing cataract surgery
Purity 9514Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Nepafenac D5 (AHR-9434 D5 AL-6515 D5) Cat No HY-17357S
Nepafenac D5 is the deuterium labeled Nepafenacwhich is a selective COX-2 inhibitor
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Nimesulide (R805) Cat No HY-B0363
Nimesulide is a selective inhibitor withCOX-2s of 70 nM-70 μM in a time-dependent mannerIC50
but it shows no effect on COX-1 (IC gt100 μM)50
Nimesulide has potent anti-inflammatory analgesicand antipyretic properties
Purity 9991Clinical Data Phase 4Size 10 mM times 1 mL 100 mg 500 mg
Nimesulide D5Cat No HY-B0363S
Nimesulide D5 is a deuterium labeled NimesulideNimesulide is a selective inhibitor withCOX-2
s of 70 nM-70 μM in a time-dependent mannerIC50
but it shows no effect on COX-1 (IC gt100 μM)50
Nimesulide has potent anti-inflammatory analgesicand antipyretic properties
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 11
Nitroaspirin (NCX 4016) Cat No HY-123823
Nitroaspirin (NCX 4016) is a nitric oxide (NO)donor and a nitro-derivative of Aspirin whichcombines with Nitroaspirin to inhibitcyclooxygenase
Purity gt98Clinical DataSize 1 mg 5 mg
Nitroflurbiprofen (HCT 1206 NO-flurbiprofen Nitroxybutyl flurbiprofen) Cat No HY-U00013
Nitroflurbiprofen is a ( )cyclooxygenase COXinhibitor with nitric oxide (NO)-donatingproperties modulates the increased intrahepaticvascular tone in portal hypertensive cirrhoticrats
Purity 9964Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
NS-398Cat No HY-13913
NS-398 is a non-steroidal an-inflammatory agentwith analgesic and antipyretic effects andselectively inhibits prostaglandin GH synthase2cyclooxygenase 2 ( ) activity with an COX-2 IC50
of 38 μM and has no effect on COX-1 at 100 μM
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Oxaprozin (Oxaprozinum Wy21743) Cat No HY-B0808
Oxaprozin is an inhibitor of both andCOX-1 with s of 22 μM and 36 μM for humanCOX-2 IC50
platelet COX-1 and IL-1-stimulated human synovialcell COX-2 respectively Oxaprozin also inhibitsthe activation of NF-κB
Purity 9963Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Oxaprozin D4 (Wy-21743 D4) Cat No HY-B0808S
Oxaprozin D4 is the deuterium labeled Oxaprozinwhich is a non-steroidal anti-inflammatory drug(NSAID)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
Pamicogrel (KBT3022) Cat No HY-U00175
Pamicogrel (KBT3022) is a ( )cyclooxygenase COXinhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Paradol ([6]-Gingerone [6]-Paradol) Cat No HY-14617
Paradol is a pungent phenolic substance found inginger and other Zingiberaceae plants Paradol isan effective inhibitor of tumor promotion in mouseskin carcinogenesis binds to cyclooxygenase
active site(COX)-2
Purity 9988Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Parecoxib (SC 69124) Cat No HY-17474
Parecoxib is a potent and selective COX-2inhibitor IC50 value Target COX-2 in vitro Theprodrug Parecoxib as well as its active metaboliteval have a specific affinity to the cannabinoid(CB) receptor measured in CB1-expressing HEK 293cells and rat brain tissue
Purity 9932Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Parecoxib Sodium (SC 69124A) Cat No HY-17474A
Parecoxib Sodium (SC 69124A) is a potent andselective COX-2 inhibitor
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
PelubiprofenCat No HY-12383
Pelubiprofen an orally active and non-steroidalanti-inflammatory drug is a member of the2-arylpropionic acid family and has relativelyselective effects on activityCOX-2
Purity gt98Clinical Data No Development ReportedSize 100 mg 250 mg 500 mg
12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Phenacetin (Acetophenetidin) Cat No HY-B0476
Phenacetin is a non-opioid analgesic withoutanti-inflammatory properties inhibits COX-3activity Target COX Phenacetin is apain-relieving and fever-reducing drug Phenacetinwas withdrawn from the Canadian market in June1973 due to concerns regarding nephropathy
Purity 9909Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
PhenylbutazoneCat No HY-B0230
Phenylbutazone is used as a non-steroidalanti-inflammatory agent for the treatment ofchronic pain including the symptoms of arthritisTarget Others Phenylbutazone was originally madeavailable for use in humans for the treatment ofrheumatoid arthritis and gout in 1949
Purity 9886Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg
Piroxicam (CP-16171) Cat No HY-B0253
Piroxicam (CP-16171) is a non-steroidalanti-inflammatory drugs acts as a inhibitorCOXwith s of 47 25 μM for human monocyte COX-1IC50
and COX-2 respectively
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g 10 g
Piroxicam D3 (CP-16171 D3) Cat No HY-B0253S
Piroxicam D3 (CP-16171 D3) is deuterium labeledPiroxicam Piroxicam is a non-steroidalanti-inflammatory drugs acts as a COX inhibitorwith IC s of 47 25 μM for human monocyte COX-150
and COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Prim-O-glucosylcimifuginCat No HY-N0635
Prim-O-glucosylcimifugin exerts anti-inflammatoryeffects through the inhibition of and iNOS COX-2expression by through regulating JAK2STAT3signaling
Purity 9976Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Propyphenazone (4-Isopropylantipyrine Isopropylphenazone) Cat No HY-A0273
Propyphenazone is a pyrazolone derivative withanti-inflammatory analgesic and antipyreticactivity Propyphenazone-based analogues asprodrugs and selective cyclooxygenase-2inhibitors
Purity 9994Clinical Data LaunchedSize 10 mM times 1 mL 250 mg
PsoralidinCat No HY-N0232
Psoralidin isolated from the seed of Psoralea is a dual inhibitor of andcorylifolia COX-2
regulates ionizing radiation (IR)-induced5-LOXpulmonary inflammationAnti-canceranti-bacterial and anti-inflammatory properties
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg
Rebamipide (OPC12759 Proamipide) Cat No HY-B0360
Rebamipide (OPC12759) is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Rebamipide D4 (OPC12759 D4 Proamipide D4) Cat No HY-B0360S
Rebamipide D4 (OPC12759 D4) is deuterium labeledRebamipide Rebamipide is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Revaprazan hydrochlorideCat No HY-N7067
Revaprazan hydrochloride is a novel acid pumpantagonist ( ) Revaprazan hydrochlorideAPAreduces expression and has significantCOX-2anti-inflammatory actions activities in H pyloriinfection
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 13
RHC 80267 (U-57908) Cat No HY-107416
RHC 80267 (U-57908) is a potent and selectiveinhibitor of (withdiacylglycerol lipase (DAGL)
of 4 μM in canine platelets) RHC-80267IC50
inhibits activity with an of 4cholinesterase IC50
μM thereby enhancing the relaxation evoked byacetylcholine
Purity gt98Clinical Data No Development ReportedSize 10 mM1m 10 mg 25 mg 50 mg 100 mg
Roburic acidCat No HY-N0481
Roburic acid a tetracyclic triterpenoid found in acts as an inhibitor ofGentiana macrophylla
with s of 5 and 9 μM for COX-1 andCOX IC50
COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Rofecoxib (MK 966) Cat No HY-17372
Rofecoxib is a potent specific and orally active inhibitor with s of 26 and 18 nM forCOX-2 IC50
human COX-2 in human osteosarcoma cells andChinese hamster ovary cells with a 1000-foldselectivity for COX-2 over human COX-1 (IC gt50
50 μM in U937 cells and gt 15 μM inhellip
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Rutaecarpine (Rutecarpine) Cat No HY-N0147
Rutaecarpine an alkaloid of isEvodia rutaecarpaan inhibitor of with an value of 028COX-2 IC50
μM
Purity 9911Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
RWJ 63556Cat No HY-U00022
RWJ 63556 is an orally active COX-2 inhibitor withselective5-lipoxygenase
anti-inflammatory activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
S-(+)-Ketoprofen ((S)-Ketoprofen Dexketoprofen) Cat No HY-B2137
S-(+)-Ketoprofen is a potent inhibitor of both and with s of 19 and 27 nMCOX-1 COX-2 IC50
respectively
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
S-(+)-Marmesin ((+)-Marmesin (S)-Marmesin) Cat No HY-N2176
S-(+)-Marmesin is a natural coumarin exhibiting dual inhibitory activityCOX-25-LOX
Purity 9904Clinical Data No Development ReportedSize 2 mg 5 mg 10 mg 25 mg 50 mg
S-2474Cat No HY-19212
S-2474 is an inhibitor of and COX-2 5-lipoxygenase with s of 11 nM and 27 μM for COX-2(5-LO) IC50
and COX-1 in human intact cells and used as anonsteroidal anti-inflammatory drug
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Salicin (D-(minus)-Salicin Salicoside) Cat No HY-N0149
Salicin is a natural inhibitorCOX
Purity 9960Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
Salicylic acid (2-Hydroxybenzoic acid) Cat No HY-B0167
Salicylic acid inhibits cyclo-oxygenase-2 ( )COX-2activity independently of transcription factor(NF-κB) activation
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
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SC-560Cat No HY-59105
SC-560 is a potent and selective inhibitorCOX-1with an of 9 nMIC50
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SC57666Cat No HY-U00129
SC57666 is a selective inhibitor with anCOX2 of 26 nMIC50
Purity 9894Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 20 mg
SC58451Cat No HY-U00239
SC58451 is a potent and selective Cox-2inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Sodium Salicylate (Salicylic acid sodium salt
2-Hydroxybenzoic acid sodium salt) Cat No HY-B0167A
Sodium Salicylate inhibits cyclo-oxygenase-2( ) activity independently of transcriptionCOX-2factor (NF-κB) activation
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
Sulindac (MK-231) Cat No HY-B0008
Sulindac (MK-231) is a non-steroidalantiinflammatory agent acts as a COX-2inhibitor and inhibits overexpression of COX-2
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
SyringaldehydeCat No HY-N1390
Syringaldehyde is a polyphenolic compoundbelonging to the group of flavonoids and is foundin different plant species like Manihot
and esculenta Magnolia officinalisSyringaldehyde moderately inhibits activityCOX-2with an of 35 μgmLIC50
Purity 9996Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Tenidap (CP-66248) Cat No HY-105028
Tenidap a non-steroidal anti-inflammatory drugis a selective inhibitor with valuesCOX-1 IC50
of 003 microM and 12 microM for COX-1 and COX-2respectively Tenidap has anti-inflammatory andantirheumatic properties Tenidap is also aspecific SLC26A3 inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tenoxicam (Ro-12-0068) Cat No HY-B0440
Tenoxicam (Ro-12-0068) an antiinflammatory agentwith analgesic and antipyretic properties
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) Cat No HY-112731
TFAP is a selective cyclooxygenase-1 (COX-1)inhibitor with an of 08 μMIC50
Purity 9997Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Thioflosulide (L-745337) Cat No HY-19217
Thioflosulide (L-745337) is a selective inhibitor with an ofcyclooxygenase-2 (COX2) IC50
23 nM and shows anti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
wwwMedChemExpresscom 15
Tilmacoxib (JTE522 JTP19605 RWJ57504) Cat No HY-U00197
Tilmacoxib (JTE522) is a highly selectivetime-dependent and irreversible human COX-2inhibitor with an of 85 nM in an enzymeIC50
assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Timegadine (SR1368) Cat No HY-100125
Timegadine a new antiinflammatory agent is foundto be a potent competitive inhibitor of
( ) and withcyclo-oxygenase COX lipo-oxygenases ranging from 5 nM (washed rabbit platelets)IC50
to 20 μM (rat brain) for COX and 100 μM forlipo-oxygenase both in the cytosol fractionhellip
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tolfenamic Acid (GEA 6414) Cat No HY-B0335
Tolfenamic Acid (GEA 6414) is a non-steroidalanti-inflammatory and anti-cancer agentselectively inhibits with an of 1349COX-2 IC50
μM (353 μgmL) in LPS-treated (COX-2) canine DH82monocytemacrophage cells but shows no effect onCOX-1
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 10 g
Tolmetin sodium dihydrateCat No HY-B1489
Tolmetin sodium dihydrate is a non-steroidalantiinflammatory agent and acts as anon-selective inhibitorCOX
Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
TriflusalCat No HY-B0531
Triflusal irreversibly inhibits the production ofthromboxane-B2 in platelets by acetylatingcycloxygenase-1 Target COX Triflusal at 10 mM100 mM and 1 M decreases LDH efflux in rat brainslices after anoxiareoxygenation by 24 35 and49 respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Valdecoxib (SC 65872) Cat No HY-15762
Valdecoxib is a highly potent and selectiveinhibitor of with s of 5 nM and 140 μMCOX-2 IC50
for COX-2 and COX-1 respeceively Valdecoxib canbe used in the research of arthritis and pain
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Veratric acid (34-Dimethoxybenzoic acid) Cat No HY-N2007
Veratric acid (34-Dimethoxybenzoic acid) is anorally active phenolic compound derived fromvegetables and fruits has antioxidant andanti-inflammatory activities
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
XanthohumolCat No HY-N1067
Xanthohumol is one of the principal flavonoidsisolated from hops the inhibitor ofdiacylglycerol acetyltransferase ( ) DGAT COX-1and COX-2 and shows anti-cancer andanti-angiogenic activities
Purity 9968Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 25 mg
Zaltoprofen (CN100) Cat No HY-B0619
Zaltoprofen(CN100) is an inhibitor of COX fortreatment of arthritis
Purity 9909Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
[10]-ShogaolCat No HY-N2434
[10]-Shogaol is an antioxidant from Zingiber for human skin cell growth and aofficinale
migration enhancer [10]-Shogaol inhibits COX-2with an of 75 μM and has antiproliferationIC50
activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
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[8]-ShogaolCat No HY-N2435
-Shogaol one of the pungent phenolic compounds inginger exhibits anti-platelet activity ( =5IC50
μM) and inhibits COX-2 ( =175 μM) -ShogaolIC50
induces apoptosis in human leukemia cells
Purity 9918Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-Humulene (Humulene α-Caryophyllene) Cat No HY-N6968
α-Humulene is a main constituent of Tanacetum L (Asteraceae) essential oil withvulgare
anti-inflammation (IC =15plusmn2 microgmL) α-Humulene50
inhibits and expressionCOX-2 iNOS
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-ChaconineCat No HY-129113
α-Chaconine isolated from a Solanum L cv Jayoung inhibits thetuberosum
expressions of and atCOX-2 IL-1β IL-6 TNF-αthe transcriptional level
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 17
Ginsenoside Rg5Cat No HY-N0908
Ginsenoside Rg5 is the main component of Redginseng Ginsenoside blocks binding of to itsIGF-1receptor with an of ~90 nM Ginsenoside Rg5IC50
also inhibits the mRNA expression of viaCOX-2suppression of the DNA binding activities of
NF-κB p65
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
GnetolCat No HY-126052
Gnetol is a phenolic compound isolated from theroot of Brongn Gnetol potentlyGnetum ulainhibits ( of 078 μM) and COX-1 IC50 HDACGnetol is a potent inhibitor with antyrosinase
of 45 μM for murine tyrosinase andIC50
suppresses melanin biosynthesis
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Guaiacol (2-Methoxyphenol) Cat No HY-N1380
Guaiacol a phenolic compound isolated from Guaiacresin inhibits LPS-stimulated expressionCOX-2and activation Anti-inflammatory activityNF-κB
Purity 9929Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
GW-406381Cat No HY-119304
GW406381 a highly selective cyclooxygenase-2 inhibitor attenuates spontaneous ectopic(COX-2)
discharge in sural nerves of rats followingchronic constriction injury
Purity 9959Clinical DataSize 10 mM times 1 mL 1 mg
HamaudolCat No HY-N6891
Hamaudol is a chromone isolated from Saposhnikovia Hamaudol shows significant inhibitorydivaricata
activity on and cyclooxygenase (COX)-1 COX-2activities with values of 030 057 mMIC50
respectively and has potent analgesia andanti-inflammary effects
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
HarpagosideCat No HY-N0396
Harpagoside is isolated from Harpagophytum Harpagoside has inhibitory effectsprocumbens (Hp)
on and activity and inhibits NOCOX-1 COX-2production
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
HexahydrocurcuminCat No HY-N0929
Hexahydrocurcumin is a natural compound whichposesses anticancer and anti-inflammatoryactivities selective COX-2 inhibitor
Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Ibuprofen ((plusmn)-Ibuprofen) Cat No HY-78131
Ibuprofen is an anti-inflammatory inhibitortargeting and with s of 13 μMCOX-1 COX-2 IC50
and 370 μM respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Ibuprofen D3 ((plusmn)-Ibuprofen D3) Cat No HY-78131S
Ibuprofen D3 is a deuterium labeled IbuprofenIbuprofen is a COX-1 and COX-2 inhibitor with IC s50
of 13 μM and 370 μM
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Iguratimod (T614) Cat No HY-17009
Iguratimod is an antirheumatic agent acts as aninhibitor of with an of 20 μM (77COX-2 IC50
μgmL) but shows no effect on COX-1 Iguratimodalso inhibits macrophage migration inhibitoryfactor ( ) with an of 681 μMMIF IC50
Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
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Imrecoxib (BAP-909) Cat No HY-114200
Imrecoxib (BAP-909) is a novel and selectivecyclooxygenase 2 ( ) inhibitor with an COX-2 IC50
value of 18 nM it also inhibits COX1- activitywith an value of 115 nM Imrecoxib (BAP-909)IC50
has anti-inflammatory effect
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 50 mg 100 mg
Indobufen (Ibustrin) Cat No HY-18763
Indobufen is a platelet aggregation inhibitorIndobufen is a reversible platelet cyclooxygenase( ) activity inhibitor Indobufen suppressesCoxthromboxane A (TxA ) synthesis Indobufen2 2
down-regulates tissue factor (TF) in monocytes
Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Indomethacin (Indometacin) Cat No HY-14397
Indomethacin is a potent and nonselectiveinhibitor of and with s of 18 nMCOX1 COX2 IC50
and 26 nM for human COX-1 and COX-2 respectivelyin CHO cells
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Inulicin (1-O-Acetylbritannilactone) Cat No HY-N0896
Inulicin (1-O-Acetylbritannilactone) is an activecompound isolated from InulicinInula Britannica L(1-O-Acetylbritannilactone) inhibits VEGF-mediatedactivation of and Src FAK
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Isoorientin (Homoorientin) Cat No HY-N0767
Isoorientin is a potent inhibitor of withCOX-2an value of 39 μMIC50
Purity 9924Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 25 mg 50 mg
JaceosidinCat No HY-N0831
Jaceosidin is a flavonoid isolated from induces apoptosis in cancerArtemisia vestita
cells activates and down-regulates Mcl-1 andBaxc-FLIP expression
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 25 mg
Ketoprofen (RP-19583) Cat No HY-B0227
Ketoprofen (RP-19583) is a non-steroidalantiinflammatory agent acting as a potentinhibitor of with s of 2 nM and 26 nMCOX IC50
for COX-1 and COX-2 in human blood monocytesrespectively
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Ketorolac (RS37619) Cat No HY-B0580
Ketorolac is a non-steroidal anti-inflammatoryagent acting as a nonselective inhibitorCOXwith s of 20 nM for COX-1 and 120 nM forIC50
COX-2
Purity gt98Clinical Data LaunchedSize 100 mg 500 mg
Ketorolac D5Cat No HY-B0580S
Ketorolac D5 is a deuterium labeled KetorolacKetorolac is a non-steroidal anti-inflammatoryagent acting as a nonselective inhibitorCOXwith s of 20 nM for COX-1 and 120 nM forIC50
COX-2
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ketorolac tromethamine salt (Ketorolac Tromethamine
Ketorolac tris salt RS37619 tromethamine salt) Cat No HY-B0138
Ketorolac tromethamine salt (RS37619 tromethaminesalt) is a non-steroidal anti-inflammatory agentacting as a nonselective inhibitor withCOX
s of 20 nM for COX-1 and 120 nM for COX-2IC50
Purity 9994Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
wwwMedChemExpresscom 9
Licofelone (ML-3000) Cat No HY-B1452
Licofelone (ML-3000) is a dual COX5-lipoxygenase inhibitor ( =021018 μM(5-LOX) IC50
respectively) for the treatment of osteoarthritisLicofelone exerts anti-inflammatory andanti-proliferative effects
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
Lornoxicam (Chlortenoxicam Ro 13-9297 TS110) Cat No HY-B0367
Lornoxicam a COX-1 and COX-2 inhibitor is a newnonsteroidal anti-inflammatory drug (NSAID)Target COX Lornoxicam showed a balancedinhibition of COX-1-2 exhibiting the lowest IC50(0005 microM0008 microM) of the large panel ofNSAIDs tested
Purity 9831Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
LoxoprofenCat No HY-B0578
Loxoprofen is a non-steroidal anti-inflammatorydrug Target COX Loxoprofen is a non-steroidalanti-inflammatory drug in the propionic acidderivatives group which also includes ibuprofenand naproxen among others
Purity 9882Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
LY 178002Cat No HY-101579
LY 178002 is a potent inhibitor of 5-lipoxygenase with of 06 μM(5-LPO) phospholipase A2 IC50
for 5-lipoxygenase inhibits cellular productionof LTB4 by human polymorphonuclear leukocytes andshows relatively weak inhibition on cyclooxygenase
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
MavacoxibCat No HY-119447
Mavacoxib is a selective oral long-acting inhibitor and acyclooxygenase-2 (COX-2)
long-acting non-steroidal anti-inflammatory drug(NSAID) Mavacoxib is used to treat pain andinflammation associated with degenerative jointdisease in dogs
Purity 9983Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Mefenamic acidCat No HY-B0574
Mefenamic acid is a non-steroidalanti-inflammatory agent acting as a competitiveinhibitor of and with s of 40hCOX-1 hCOX-2 IC50
nM and 3 μM for hCOX-1 and hCOX-2 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
MeloxicamCat No HY-B0261
Meloxicam is a non-steroidal antiinflammatoryagent inhibits activity with s of 049COX IC50
microM and 366 microM for COX-2 and COX-1 respectively
Purity 9807Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Meloxicam D4Cat No HY-B0261S
Meloxicam D4 is deuterium labeled MeloxicamMeloxicam is a non-steroidal antiinflammatoryagent inhibits COX activity with IC s of 049 microM50
and 366 microM for COX-2 and COX-1 respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Metamizole sodium hydrateCat No HY-B1279
Metamizole sodium hydrate is a potent analgesicdrug that has been demonstrated to inhibitcyclooxygenase (COX)
Purity gt980Clinical Data LaunchedSize 500 mg
Methyl Salicylate (Wintergreen oil) Cat No HY-Y0189
Methyl Salicylate (Wintergreen oil) is a topicalanalgesic and anti-inflammatory agent Also usedas a pesticide a denaturant a fragranceingredient and a flavoring agent in food andtobacco products A systemic acquired resistance(SAR) signal in tobacco
Purity 9998Clinical Data No Development ReportedSize 10 mM times 1 mL 50 mg
10 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
N-trans-Feruloyltyramine (N-feruloyltyramine Moupinamide) Cat No HY-N2410
N-trans-Feruloyltyramine (N-feruloyltyramine) analkaloid from is an inhibitor of Piper nigru COX1and with potential antioxidant propertiesCOX2N-trans-Feruloyltyramine possessesanti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
Nabumetone (BRL14777) Cat No HY-B0559
Nabumetone is an orally active non-acidicanti-inflammatory agent acts as a potent andselective inhibitor and is the prodrug ofCOX-2the active metabolite 6MNA
Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Naproxen ((S)-Naproxen) Cat No HY-15030
Naproxen is a and inhibitor withCOX-1 COX-2s of 872 and 515 μM respectively in cellIC50
assay
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Naproxen etemesil (LT-NS 001 MX 1094) Cat No HY-19675
Naproxen etemesil is a lipophilic non-acidicinactive prodrug of naproxen that is hydrolysed topharmacologically active Naproxen once absorbedNaproxen is a and inhibitor withCOX-1 COX-2
s of 872 and 515 μM respectively in cellIC50
assay
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Naproxen sodiumCat No HY-15030A
Naproxen sodium is a and inhibitorCOX-1 COX-2with s of 872 and 515 μM respectively inIC50
cell assay
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) Cat No HY-N0722
Neochlorogenic acid is a natural polyphenoliccompound found in dried fruits and other plantsNeochlorogenic acid inhibits the production of
and Neochlorogenic acid suppressesTNF-α IL-1β protein expressioniNOS and COX-2
Purity 9946Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Nepafenac (AHR 9434 AL 6515) Cat No HY-17357
Nepafenac(AHR 9434 AL 6515 Nevanac) is aselective COX-2 inhibitor is prodrug of AmfenacIC50 value Target COX-2 Nepafenac is a NSAID(nonsteroidal anti inflammatory drug) that isroutinely used in opthamology to control painfollowing cataract surgery
Purity 9514Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Nepafenac D5 (AHR-9434 D5 AL-6515 D5) Cat No HY-17357S
Nepafenac D5 is the deuterium labeled Nepafenacwhich is a selective COX-2 inhibitor
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Nimesulide (R805) Cat No HY-B0363
Nimesulide is a selective inhibitor withCOX-2s of 70 nM-70 μM in a time-dependent mannerIC50
but it shows no effect on COX-1 (IC gt100 μM)50
Nimesulide has potent anti-inflammatory analgesicand antipyretic properties
Purity 9991Clinical Data Phase 4Size 10 mM times 1 mL 100 mg 500 mg
Nimesulide D5Cat No HY-B0363S
Nimesulide D5 is a deuterium labeled NimesulideNimesulide is a selective inhibitor withCOX-2
s of 70 nM-70 μM in a time-dependent mannerIC50
but it shows no effect on COX-1 (IC gt100 μM)50
Nimesulide has potent anti-inflammatory analgesicand antipyretic properties
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 11
Nitroaspirin (NCX 4016) Cat No HY-123823
Nitroaspirin (NCX 4016) is a nitric oxide (NO)donor and a nitro-derivative of Aspirin whichcombines with Nitroaspirin to inhibitcyclooxygenase
Purity gt98Clinical DataSize 1 mg 5 mg
Nitroflurbiprofen (HCT 1206 NO-flurbiprofen Nitroxybutyl flurbiprofen) Cat No HY-U00013
Nitroflurbiprofen is a ( )cyclooxygenase COXinhibitor with nitric oxide (NO)-donatingproperties modulates the increased intrahepaticvascular tone in portal hypertensive cirrhoticrats
Purity 9964Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
NS-398Cat No HY-13913
NS-398 is a non-steroidal an-inflammatory agentwith analgesic and antipyretic effects andselectively inhibits prostaglandin GH synthase2cyclooxygenase 2 ( ) activity with an COX-2 IC50
of 38 μM and has no effect on COX-1 at 100 μM
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Oxaprozin (Oxaprozinum Wy21743) Cat No HY-B0808
Oxaprozin is an inhibitor of both andCOX-1 with s of 22 μM and 36 μM for humanCOX-2 IC50
platelet COX-1 and IL-1-stimulated human synovialcell COX-2 respectively Oxaprozin also inhibitsthe activation of NF-κB
Purity 9963Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Oxaprozin D4 (Wy-21743 D4) Cat No HY-B0808S
Oxaprozin D4 is the deuterium labeled Oxaprozinwhich is a non-steroidal anti-inflammatory drug(NSAID)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
Pamicogrel (KBT3022) Cat No HY-U00175
Pamicogrel (KBT3022) is a ( )cyclooxygenase COXinhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Paradol ([6]-Gingerone [6]-Paradol) Cat No HY-14617
Paradol is a pungent phenolic substance found inginger and other Zingiberaceae plants Paradol isan effective inhibitor of tumor promotion in mouseskin carcinogenesis binds to cyclooxygenase
active site(COX)-2
Purity 9988Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Parecoxib (SC 69124) Cat No HY-17474
Parecoxib is a potent and selective COX-2inhibitor IC50 value Target COX-2 in vitro Theprodrug Parecoxib as well as its active metaboliteval have a specific affinity to the cannabinoid(CB) receptor measured in CB1-expressing HEK 293cells and rat brain tissue
Purity 9932Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Parecoxib Sodium (SC 69124A) Cat No HY-17474A
Parecoxib Sodium (SC 69124A) is a potent andselective COX-2 inhibitor
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
PelubiprofenCat No HY-12383
Pelubiprofen an orally active and non-steroidalanti-inflammatory drug is a member of the2-arylpropionic acid family and has relativelyselective effects on activityCOX-2
Purity gt98Clinical Data No Development ReportedSize 100 mg 250 mg 500 mg
12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Phenacetin (Acetophenetidin) Cat No HY-B0476
Phenacetin is a non-opioid analgesic withoutanti-inflammatory properties inhibits COX-3activity Target COX Phenacetin is apain-relieving and fever-reducing drug Phenacetinwas withdrawn from the Canadian market in June1973 due to concerns regarding nephropathy
Purity 9909Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
PhenylbutazoneCat No HY-B0230
Phenylbutazone is used as a non-steroidalanti-inflammatory agent for the treatment ofchronic pain including the symptoms of arthritisTarget Others Phenylbutazone was originally madeavailable for use in humans for the treatment ofrheumatoid arthritis and gout in 1949
Purity 9886Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg
Piroxicam (CP-16171) Cat No HY-B0253
Piroxicam (CP-16171) is a non-steroidalanti-inflammatory drugs acts as a inhibitorCOXwith s of 47 25 μM for human monocyte COX-1IC50
and COX-2 respectively
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g 10 g
Piroxicam D3 (CP-16171 D3) Cat No HY-B0253S
Piroxicam D3 (CP-16171 D3) is deuterium labeledPiroxicam Piroxicam is a non-steroidalanti-inflammatory drugs acts as a COX inhibitorwith IC s of 47 25 μM for human monocyte COX-150
and COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Prim-O-glucosylcimifuginCat No HY-N0635
Prim-O-glucosylcimifugin exerts anti-inflammatoryeffects through the inhibition of and iNOS COX-2expression by through regulating JAK2STAT3signaling
Purity 9976Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Propyphenazone (4-Isopropylantipyrine Isopropylphenazone) Cat No HY-A0273
Propyphenazone is a pyrazolone derivative withanti-inflammatory analgesic and antipyreticactivity Propyphenazone-based analogues asprodrugs and selective cyclooxygenase-2inhibitors
Purity 9994Clinical Data LaunchedSize 10 mM times 1 mL 250 mg
PsoralidinCat No HY-N0232
Psoralidin isolated from the seed of Psoralea is a dual inhibitor of andcorylifolia COX-2
regulates ionizing radiation (IR)-induced5-LOXpulmonary inflammationAnti-canceranti-bacterial and anti-inflammatory properties
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg
Rebamipide (OPC12759 Proamipide) Cat No HY-B0360
Rebamipide (OPC12759) is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Rebamipide D4 (OPC12759 D4 Proamipide D4) Cat No HY-B0360S
Rebamipide D4 (OPC12759 D4) is deuterium labeledRebamipide Rebamipide is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Revaprazan hydrochlorideCat No HY-N7067
Revaprazan hydrochloride is a novel acid pumpantagonist ( ) Revaprazan hydrochlorideAPAreduces expression and has significantCOX-2anti-inflammatory actions activities in H pyloriinfection
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 13
RHC 80267 (U-57908) Cat No HY-107416
RHC 80267 (U-57908) is a potent and selectiveinhibitor of (withdiacylglycerol lipase (DAGL)
of 4 μM in canine platelets) RHC-80267IC50
inhibits activity with an of 4cholinesterase IC50
μM thereby enhancing the relaxation evoked byacetylcholine
Purity gt98Clinical Data No Development ReportedSize 10 mM1m 10 mg 25 mg 50 mg 100 mg
Roburic acidCat No HY-N0481
Roburic acid a tetracyclic triterpenoid found in acts as an inhibitor ofGentiana macrophylla
with s of 5 and 9 μM for COX-1 andCOX IC50
COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Rofecoxib (MK 966) Cat No HY-17372
Rofecoxib is a potent specific and orally active inhibitor with s of 26 and 18 nM forCOX-2 IC50
human COX-2 in human osteosarcoma cells andChinese hamster ovary cells with a 1000-foldselectivity for COX-2 over human COX-1 (IC gt50
50 μM in U937 cells and gt 15 μM inhellip
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Rutaecarpine (Rutecarpine) Cat No HY-N0147
Rutaecarpine an alkaloid of isEvodia rutaecarpaan inhibitor of with an value of 028COX-2 IC50
μM
Purity 9911Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
RWJ 63556Cat No HY-U00022
RWJ 63556 is an orally active COX-2 inhibitor withselective5-lipoxygenase
anti-inflammatory activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
S-(+)-Ketoprofen ((S)-Ketoprofen Dexketoprofen) Cat No HY-B2137
S-(+)-Ketoprofen is a potent inhibitor of both and with s of 19 and 27 nMCOX-1 COX-2 IC50
respectively
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
S-(+)-Marmesin ((+)-Marmesin (S)-Marmesin) Cat No HY-N2176
S-(+)-Marmesin is a natural coumarin exhibiting dual inhibitory activityCOX-25-LOX
Purity 9904Clinical Data No Development ReportedSize 2 mg 5 mg 10 mg 25 mg 50 mg
S-2474Cat No HY-19212
S-2474 is an inhibitor of and COX-2 5-lipoxygenase with s of 11 nM and 27 μM for COX-2(5-LO) IC50
and COX-1 in human intact cells and used as anonsteroidal anti-inflammatory drug
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Salicin (D-(minus)-Salicin Salicoside) Cat No HY-N0149
Salicin is a natural inhibitorCOX
Purity 9960Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
Salicylic acid (2-Hydroxybenzoic acid) Cat No HY-B0167
Salicylic acid inhibits cyclo-oxygenase-2 ( )COX-2activity independently of transcription factor(NF-κB) activation
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
14 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SC-560Cat No HY-59105
SC-560 is a potent and selective inhibitorCOX-1with an of 9 nMIC50
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SC57666Cat No HY-U00129
SC57666 is a selective inhibitor with anCOX2 of 26 nMIC50
Purity 9894Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 20 mg
SC58451Cat No HY-U00239
SC58451 is a potent and selective Cox-2inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Sodium Salicylate (Salicylic acid sodium salt
2-Hydroxybenzoic acid sodium salt) Cat No HY-B0167A
Sodium Salicylate inhibits cyclo-oxygenase-2( ) activity independently of transcriptionCOX-2factor (NF-κB) activation
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
Sulindac (MK-231) Cat No HY-B0008
Sulindac (MK-231) is a non-steroidalantiinflammatory agent acts as a COX-2inhibitor and inhibits overexpression of COX-2
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
SyringaldehydeCat No HY-N1390
Syringaldehyde is a polyphenolic compoundbelonging to the group of flavonoids and is foundin different plant species like Manihot
and esculenta Magnolia officinalisSyringaldehyde moderately inhibits activityCOX-2with an of 35 μgmLIC50
Purity 9996Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Tenidap (CP-66248) Cat No HY-105028
Tenidap a non-steroidal anti-inflammatory drugis a selective inhibitor with valuesCOX-1 IC50
of 003 microM and 12 microM for COX-1 and COX-2respectively Tenidap has anti-inflammatory andantirheumatic properties Tenidap is also aspecific SLC26A3 inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tenoxicam (Ro-12-0068) Cat No HY-B0440
Tenoxicam (Ro-12-0068) an antiinflammatory agentwith analgesic and antipyretic properties
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) Cat No HY-112731
TFAP is a selective cyclooxygenase-1 (COX-1)inhibitor with an of 08 μMIC50
Purity 9997Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Thioflosulide (L-745337) Cat No HY-19217
Thioflosulide (L-745337) is a selective inhibitor with an ofcyclooxygenase-2 (COX2) IC50
23 nM and shows anti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
wwwMedChemExpresscom 15
Tilmacoxib (JTE522 JTP19605 RWJ57504) Cat No HY-U00197
Tilmacoxib (JTE522) is a highly selectivetime-dependent and irreversible human COX-2inhibitor with an of 85 nM in an enzymeIC50
assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Timegadine (SR1368) Cat No HY-100125
Timegadine a new antiinflammatory agent is foundto be a potent competitive inhibitor of
( ) and withcyclo-oxygenase COX lipo-oxygenases ranging from 5 nM (washed rabbit platelets)IC50
to 20 μM (rat brain) for COX and 100 μM forlipo-oxygenase both in the cytosol fractionhellip
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tolfenamic Acid (GEA 6414) Cat No HY-B0335
Tolfenamic Acid (GEA 6414) is a non-steroidalanti-inflammatory and anti-cancer agentselectively inhibits with an of 1349COX-2 IC50
μM (353 μgmL) in LPS-treated (COX-2) canine DH82monocytemacrophage cells but shows no effect onCOX-1
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 10 g
Tolmetin sodium dihydrateCat No HY-B1489
Tolmetin sodium dihydrate is a non-steroidalantiinflammatory agent and acts as anon-selective inhibitorCOX
Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
TriflusalCat No HY-B0531
Triflusal irreversibly inhibits the production ofthromboxane-B2 in platelets by acetylatingcycloxygenase-1 Target COX Triflusal at 10 mM100 mM and 1 M decreases LDH efflux in rat brainslices after anoxiareoxygenation by 24 35 and49 respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Valdecoxib (SC 65872) Cat No HY-15762
Valdecoxib is a highly potent and selectiveinhibitor of with s of 5 nM and 140 μMCOX-2 IC50
for COX-2 and COX-1 respeceively Valdecoxib canbe used in the research of arthritis and pain
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Veratric acid (34-Dimethoxybenzoic acid) Cat No HY-N2007
Veratric acid (34-Dimethoxybenzoic acid) is anorally active phenolic compound derived fromvegetables and fruits has antioxidant andanti-inflammatory activities
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
XanthohumolCat No HY-N1067
Xanthohumol is one of the principal flavonoidsisolated from hops the inhibitor ofdiacylglycerol acetyltransferase ( ) DGAT COX-1and COX-2 and shows anti-cancer andanti-angiogenic activities
Purity 9968Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 25 mg
Zaltoprofen (CN100) Cat No HY-B0619
Zaltoprofen(CN100) is an inhibitor of COX fortreatment of arthritis
Purity 9909Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
[10]-ShogaolCat No HY-N2434
[10]-Shogaol is an antioxidant from Zingiber for human skin cell growth and aofficinale
migration enhancer [10]-Shogaol inhibits COX-2with an of 75 μM and has antiproliferationIC50
activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
16 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
[8]-ShogaolCat No HY-N2435
-Shogaol one of the pungent phenolic compounds inginger exhibits anti-platelet activity ( =5IC50
μM) and inhibits COX-2 ( =175 μM) -ShogaolIC50
induces apoptosis in human leukemia cells
Purity 9918Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-Humulene (Humulene α-Caryophyllene) Cat No HY-N6968
α-Humulene is a main constituent of Tanacetum L (Asteraceae) essential oil withvulgare
anti-inflammation (IC =15plusmn2 microgmL) α-Humulene50
inhibits and expressionCOX-2 iNOS
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-ChaconineCat No HY-129113
α-Chaconine isolated from a Solanum L cv Jayoung inhibits thetuberosum
expressions of and atCOX-2 IL-1β IL-6 TNF-αthe transcriptional level
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 17
Imrecoxib (BAP-909) Cat No HY-114200
Imrecoxib (BAP-909) is a novel and selectivecyclooxygenase 2 ( ) inhibitor with an COX-2 IC50
value of 18 nM it also inhibits COX1- activitywith an value of 115 nM Imrecoxib (BAP-909)IC50
has anti-inflammatory effect
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 50 mg 100 mg
Indobufen (Ibustrin) Cat No HY-18763
Indobufen is a platelet aggregation inhibitorIndobufen is a reversible platelet cyclooxygenase( ) activity inhibitor Indobufen suppressesCoxthromboxane A (TxA ) synthesis Indobufen2 2
down-regulates tissue factor (TF) in monocytes
Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
Indomethacin (Indometacin) Cat No HY-14397
Indomethacin is a potent and nonselectiveinhibitor of and with s of 18 nMCOX1 COX2 IC50
and 26 nM for human COX-1 and COX-2 respectivelyin CHO cells
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Inulicin (1-O-Acetylbritannilactone) Cat No HY-N0896
Inulicin (1-O-Acetylbritannilactone) is an activecompound isolated from InulicinInula Britannica L(1-O-Acetylbritannilactone) inhibits VEGF-mediatedactivation of and Src FAK
Purity 9938Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Isoorientin (Homoorientin) Cat No HY-N0767
Isoorientin is a potent inhibitor of withCOX-2an value of 39 μMIC50
Purity 9924Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 25 mg 50 mg
JaceosidinCat No HY-N0831
Jaceosidin is a flavonoid isolated from induces apoptosis in cancerArtemisia vestita
cells activates and down-regulates Mcl-1 andBaxc-FLIP expression
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 25 mg
Ketoprofen (RP-19583) Cat No HY-B0227
Ketoprofen (RP-19583) is a non-steroidalantiinflammatory agent acting as a potentinhibitor of with s of 2 nM and 26 nMCOX IC50
for COX-1 and COX-2 in human blood monocytesrespectively
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Ketorolac (RS37619) Cat No HY-B0580
Ketorolac is a non-steroidal anti-inflammatoryagent acting as a nonselective inhibitorCOXwith s of 20 nM for COX-1 and 120 nM forIC50
COX-2
Purity gt98Clinical Data LaunchedSize 100 mg 500 mg
Ketorolac D5Cat No HY-B0580S
Ketorolac D5 is a deuterium labeled KetorolacKetorolac is a non-steroidal anti-inflammatoryagent acting as a nonselective inhibitorCOXwith s of 20 nM for COX-1 and 120 nM forIC50
COX-2
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Ketorolac tromethamine salt (Ketorolac Tromethamine
Ketorolac tris salt RS37619 tromethamine salt) Cat No HY-B0138
Ketorolac tromethamine salt (RS37619 tromethaminesalt) is a non-steroidal anti-inflammatory agentacting as a nonselective inhibitor withCOX
s of 20 nM for COX-1 and 120 nM for COX-2IC50
Purity 9994Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
wwwMedChemExpresscom 9
Licofelone (ML-3000) Cat No HY-B1452
Licofelone (ML-3000) is a dual COX5-lipoxygenase inhibitor ( =021018 μM(5-LOX) IC50
respectively) for the treatment of osteoarthritisLicofelone exerts anti-inflammatory andanti-proliferative effects
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
Lornoxicam (Chlortenoxicam Ro 13-9297 TS110) Cat No HY-B0367
Lornoxicam a COX-1 and COX-2 inhibitor is a newnonsteroidal anti-inflammatory drug (NSAID)Target COX Lornoxicam showed a balancedinhibition of COX-1-2 exhibiting the lowest IC50(0005 microM0008 microM) of the large panel ofNSAIDs tested
Purity 9831Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
LoxoprofenCat No HY-B0578
Loxoprofen is a non-steroidal anti-inflammatorydrug Target COX Loxoprofen is a non-steroidalanti-inflammatory drug in the propionic acidderivatives group which also includes ibuprofenand naproxen among others
Purity 9882Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
LY 178002Cat No HY-101579
LY 178002 is a potent inhibitor of 5-lipoxygenase with of 06 μM(5-LPO) phospholipase A2 IC50
for 5-lipoxygenase inhibits cellular productionof LTB4 by human polymorphonuclear leukocytes andshows relatively weak inhibition on cyclooxygenase
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
MavacoxibCat No HY-119447
Mavacoxib is a selective oral long-acting inhibitor and acyclooxygenase-2 (COX-2)
long-acting non-steroidal anti-inflammatory drug(NSAID) Mavacoxib is used to treat pain andinflammation associated with degenerative jointdisease in dogs
Purity 9983Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Mefenamic acidCat No HY-B0574
Mefenamic acid is a non-steroidalanti-inflammatory agent acting as a competitiveinhibitor of and with s of 40hCOX-1 hCOX-2 IC50
nM and 3 μM for hCOX-1 and hCOX-2 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
MeloxicamCat No HY-B0261
Meloxicam is a non-steroidal antiinflammatoryagent inhibits activity with s of 049COX IC50
microM and 366 microM for COX-2 and COX-1 respectively
Purity 9807Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Meloxicam D4Cat No HY-B0261S
Meloxicam D4 is deuterium labeled MeloxicamMeloxicam is a non-steroidal antiinflammatoryagent inhibits COX activity with IC s of 049 microM50
and 366 microM for COX-2 and COX-1 respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Metamizole sodium hydrateCat No HY-B1279
Metamizole sodium hydrate is a potent analgesicdrug that has been demonstrated to inhibitcyclooxygenase (COX)
Purity gt980Clinical Data LaunchedSize 500 mg
Methyl Salicylate (Wintergreen oil) Cat No HY-Y0189
Methyl Salicylate (Wintergreen oil) is a topicalanalgesic and anti-inflammatory agent Also usedas a pesticide a denaturant a fragranceingredient and a flavoring agent in food andtobacco products A systemic acquired resistance(SAR) signal in tobacco
Purity 9998Clinical Data No Development ReportedSize 10 mM times 1 mL 50 mg
10 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
N-trans-Feruloyltyramine (N-feruloyltyramine Moupinamide) Cat No HY-N2410
N-trans-Feruloyltyramine (N-feruloyltyramine) analkaloid from is an inhibitor of Piper nigru COX1and with potential antioxidant propertiesCOX2N-trans-Feruloyltyramine possessesanti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
Nabumetone (BRL14777) Cat No HY-B0559
Nabumetone is an orally active non-acidicanti-inflammatory agent acts as a potent andselective inhibitor and is the prodrug ofCOX-2the active metabolite 6MNA
Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Naproxen ((S)-Naproxen) Cat No HY-15030
Naproxen is a and inhibitor withCOX-1 COX-2s of 872 and 515 μM respectively in cellIC50
assay
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Naproxen etemesil (LT-NS 001 MX 1094) Cat No HY-19675
Naproxen etemesil is a lipophilic non-acidicinactive prodrug of naproxen that is hydrolysed topharmacologically active Naproxen once absorbedNaproxen is a and inhibitor withCOX-1 COX-2
s of 872 and 515 μM respectively in cellIC50
assay
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Naproxen sodiumCat No HY-15030A
Naproxen sodium is a and inhibitorCOX-1 COX-2with s of 872 and 515 μM respectively inIC50
cell assay
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) Cat No HY-N0722
Neochlorogenic acid is a natural polyphenoliccompound found in dried fruits and other plantsNeochlorogenic acid inhibits the production of
and Neochlorogenic acid suppressesTNF-α IL-1β protein expressioniNOS and COX-2
Purity 9946Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Nepafenac (AHR 9434 AL 6515) Cat No HY-17357
Nepafenac(AHR 9434 AL 6515 Nevanac) is aselective COX-2 inhibitor is prodrug of AmfenacIC50 value Target COX-2 Nepafenac is a NSAID(nonsteroidal anti inflammatory drug) that isroutinely used in opthamology to control painfollowing cataract surgery
Purity 9514Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Nepafenac D5 (AHR-9434 D5 AL-6515 D5) Cat No HY-17357S
Nepafenac D5 is the deuterium labeled Nepafenacwhich is a selective COX-2 inhibitor
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Nimesulide (R805) Cat No HY-B0363
Nimesulide is a selective inhibitor withCOX-2s of 70 nM-70 μM in a time-dependent mannerIC50
but it shows no effect on COX-1 (IC gt100 μM)50
Nimesulide has potent anti-inflammatory analgesicand antipyretic properties
Purity 9991Clinical Data Phase 4Size 10 mM times 1 mL 100 mg 500 mg
Nimesulide D5Cat No HY-B0363S
Nimesulide D5 is a deuterium labeled NimesulideNimesulide is a selective inhibitor withCOX-2
s of 70 nM-70 μM in a time-dependent mannerIC50
but it shows no effect on COX-1 (IC gt100 μM)50
Nimesulide has potent anti-inflammatory analgesicand antipyretic properties
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 11
Nitroaspirin (NCX 4016) Cat No HY-123823
Nitroaspirin (NCX 4016) is a nitric oxide (NO)donor and a nitro-derivative of Aspirin whichcombines with Nitroaspirin to inhibitcyclooxygenase
Purity gt98Clinical DataSize 1 mg 5 mg
Nitroflurbiprofen (HCT 1206 NO-flurbiprofen Nitroxybutyl flurbiprofen) Cat No HY-U00013
Nitroflurbiprofen is a ( )cyclooxygenase COXinhibitor with nitric oxide (NO)-donatingproperties modulates the increased intrahepaticvascular tone in portal hypertensive cirrhoticrats
Purity 9964Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
NS-398Cat No HY-13913
NS-398 is a non-steroidal an-inflammatory agentwith analgesic and antipyretic effects andselectively inhibits prostaglandin GH synthase2cyclooxygenase 2 ( ) activity with an COX-2 IC50
of 38 μM and has no effect on COX-1 at 100 μM
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Oxaprozin (Oxaprozinum Wy21743) Cat No HY-B0808
Oxaprozin is an inhibitor of both andCOX-1 with s of 22 μM and 36 μM for humanCOX-2 IC50
platelet COX-1 and IL-1-stimulated human synovialcell COX-2 respectively Oxaprozin also inhibitsthe activation of NF-κB
Purity 9963Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Oxaprozin D4 (Wy-21743 D4) Cat No HY-B0808S
Oxaprozin D4 is the deuterium labeled Oxaprozinwhich is a non-steroidal anti-inflammatory drug(NSAID)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
Pamicogrel (KBT3022) Cat No HY-U00175
Pamicogrel (KBT3022) is a ( )cyclooxygenase COXinhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Paradol ([6]-Gingerone [6]-Paradol) Cat No HY-14617
Paradol is a pungent phenolic substance found inginger and other Zingiberaceae plants Paradol isan effective inhibitor of tumor promotion in mouseskin carcinogenesis binds to cyclooxygenase
active site(COX)-2
Purity 9988Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Parecoxib (SC 69124) Cat No HY-17474
Parecoxib is a potent and selective COX-2inhibitor IC50 value Target COX-2 in vitro Theprodrug Parecoxib as well as its active metaboliteval have a specific affinity to the cannabinoid(CB) receptor measured in CB1-expressing HEK 293cells and rat brain tissue
Purity 9932Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Parecoxib Sodium (SC 69124A) Cat No HY-17474A
Parecoxib Sodium (SC 69124A) is a potent andselective COX-2 inhibitor
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
PelubiprofenCat No HY-12383
Pelubiprofen an orally active and non-steroidalanti-inflammatory drug is a member of the2-arylpropionic acid family and has relativelyselective effects on activityCOX-2
Purity gt98Clinical Data No Development ReportedSize 100 mg 250 mg 500 mg
12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Phenacetin (Acetophenetidin) Cat No HY-B0476
Phenacetin is a non-opioid analgesic withoutanti-inflammatory properties inhibits COX-3activity Target COX Phenacetin is apain-relieving and fever-reducing drug Phenacetinwas withdrawn from the Canadian market in June1973 due to concerns regarding nephropathy
Purity 9909Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
PhenylbutazoneCat No HY-B0230
Phenylbutazone is used as a non-steroidalanti-inflammatory agent for the treatment ofchronic pain including the symptoms of arthritisTarget Others Phenylbutazone was originally madeavailable for use in humans for the treatment ofrheumatoid arthritis and gout in 1949
Purity 9886Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg
Piroxicam (CP-16171) Cat No HY-B0253
Piroxicam (CP-16171) is a non-steroidalanti-inflammatory drugs acts as a inhibitorCOXwith s of 47 25 μM for human monocyte COX-1IC50
and COX-2 respectively
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g 10 g
Piroxicam D3 (CP-16171 D3) Cat No HY-B0253S
Piroxicam D3 (CP-16171 D3) is deuterium labeledPiroxicam Piroxicam is a non-steroidalanti-inflammatory drugs acts as a COX inhibitorwith IC s of 47 25 μM for human monocyte COX-150
and COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Prim-O-glucosylcimifuginCat No HY-N0635
Prim-O-glucosylcimifugin exerts anti-inflammatoryeffects through the inhibition of and iNOS COX-2expression by through regulating JAK2STAT3signaling
Purity 9976Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Propyphenazone (4-Isopropylantipyrine Isopropylphenazone) Cat No HY-A0273
Propyphenazone is a pyrazolone derivative withanti-inflammatory analgesic and antipyreticactivity Propyphenazone-based analogues asprodrugs and selective cyclooxygenase-2inhibitors
Purity 9994Clinical Data LaunchedSize 10 mM times 1 mL 250 mg
PsoralidinCat No HY-N0232
Psoralidin isolated from the seed of Psoralea is a dual inhibitor of andcorylifolia COX-2
regulates ionizing radiation (IR)-induced5-LOXpulmonary inflammationAnti-canceranti-bacterial and anti-inflammatory properties
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg
Rebamipide (OPC12759 Proamipide) Cat No HY-B0360
Rebamipide (OPC12759) is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Rebamipide D4 (OPC12759 D4 Proamipide D4) Cat No HY-B0360S
Rebamipide D4 (OPC12759 D4) is deuterium labeledRebamipide Rebamipide is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Revaprazan hydrochlorideCat No HY-N7067
Revaprazan hydrochloride is a novel acid pumpantagonist ( ) Revaprazan hydrochlorideAPAreduces expression and has significantCOX-2anti-inflammatory actions activities in H pyloriinfection
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 13
RHC 80267 (U-57908) Cat No HY-107416
RHC 80267 (U-57908) is a potent and selectiveinhibitor of (withdiacylglycerol lipase (DAGL)
of 4 μM in canine platelets) RHC-80267IC50
inhibits activity with an of 4cholinesterase IC50
μM thereby enhancing the relaxation evoked byacetylcholine
Purity gt98Clinical Data No Development ReportedSize 10 mM1m 10 mg 25 mg 50 mg 100 mg
Roburic acidCat No HY-N0481
Roburic acid a tetracyclic triterpenoid found in acts as an inhibitor ofGentiana macrophylla
with s of 5 and 9 μM for COX-1 andCOX IC50
COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Rofecoxib (MK 966) Cat No HY-17372
Rofecoxib is a potent specific and orally active inhibitor with s of 26 and 18 nM forCOX-2 IC50
human COX-2 in human osteosarcoma cells andChinese hamster ovary cells with a 1000-foldselectivity for COX-2 over human COX-1 (IC gt50
50 μM in U937 cells and gt 15 μM inhellip
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Rutaecarpine (Rutecarpine) Cat No HY-N0147
Rutaecarpine an alkaloid of isEvodia rutaecarpaan inhibitor of with an value of 028COX-2 IC50
μM
Purity 9911Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
RWJ 63556Cat No HY-U00022
RWJ 63556 is an orally active COX-2 inhibitor withselective5-lipoxygenase
anti-inflammatory activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
S-(+)-Ketoprofen ((S)-Ketoprofen Dexketoprofen) Cat No HY-B2137
S-(+)-Ketoprofen is a potent inhibitor of both and with s of 19 and 27 nMCOX-1 COX-2 IC50
respectively
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
S-(+)-Marmesin ((+)-Marmesin (S)-Marmesin) Cat No HY-N2176
S-(+)-Marmesin is a natural coumarin exhibiting dual inhibitory activityCOX-25-LOX
Purity 9904Clinical Data No Development ReportedSize 2 mg 5 mg 10 mg 25 mg 50 mg
S-2474Cat No HY-19212
S-2474 is an inhibitor of and COX-2 5-lipoxygenase with s of 11 nM and 27 μM for COX-2(5-LO) IC50
and COX-1 in human intact cells and used as anonsteroidal anti-inflammatory drug
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Salicin (D-(minus)-Salicin Salicoside) Cat No HY-N0149
Salicin is a natural inhibitorCOX
Purity 9960Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
Salicylic acid (2-Hydroxybenzoic acid) Cat No HY-B0167
Salicylic acid inhibits cyclo-oxygenase-2 ( )COX-2activity independently of transcription factor(NF-κB) activation
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
14 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SC-560Cat No HY-59105
SC-560 is a potent and selective inhibitorCOX-1with an of 9 nMIC50
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SC57666Cat No HY-U00129
SC57666 is a selective inhibitor with anCOX2 of 26 nMIC50
Purity 9894Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 20 mg
SC58451Cat No HY-U00239
SC58451 is a potent and selective Cox-2inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Sodium Salicylate (Salicylic acid sodium salt
2-Hydroxybenzoic acid sodium salt) Cat No HY-B0167A
Sodium Salicylate inhibits cyclo-oxygenase-2( ) activity independently of transcriptionCOX-2factor (NF-κB) activation
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
Sulindac (MK-231) Cat No HY-B0008
Sulindac (MK-231) is a non-steroidalantiinflammatory agent acts as a COX-2inhibitor and inhibits overexpression of COX-2
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
SyringaldehydeCat No HY-N1390
Syringaldehyde is a polyphenolic compoundbelonging to the group of flavonoids and is foundin different plant species like Manihot
and esculenta Magnolia officinalisSyringaldehyde moderately inhibits activityCOX-2with an of 35 μgmLIC50
Purity 9996Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Tenidap (CP-66248) Cat No HY-105028
Tenidap a non-steroidal anti-inflammatory drugis a selective inhibitor with valuesCOX-1 IC50
of 003 microM and 12 microM for COX-1 and COX-2respectively Tenidap has anti-inflammatory andantirheumatic properties Tenidap is also aspecific SLC26A3 inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tenoxicam (Ro-12-0068) Cat No HY-B0440
Tenoxicam (Ro-12-0068) an antiinflammatory agentwith analgesic and antipyretic properties
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) Cat No HY-112731
TFAP is a selective cyclooxygenase-1 (COX-1)inhibitor with an of 08 μMIC50
Purity 9997Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Thioflosulide (L-745337) Cat No HY-19217
Thioflosulide (L-745337) is a selective inhibitor with an ofcyclooxygenase-2 (COX2) IC50
23 nM and shows anti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
wwwMedChemExpresscom 15
Tilmacoxib (JTE522 JTP19605 RWJ57504) Cat No HY-U00197
Tilmacoxib (JTE522) is a highly selectivetime-dependent and irreversible human COX-2inhibitor with an of 85 nM in an enzymeIC50
assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Timegadine (SR1368) Cat No HY-100125
Timegadine a new antiinflammatory agent is foundto be a potent competitive inhibitor of
( ) and withcyclo-oxygenase COX lipo-oxygenases ranging from 5 nM (washed rabbit platelets)IC50
to 20 μM (rat brain) for COX and 100 μM forlipo-oxygenase both in the cytosol fractionhellip
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tolfenamic Acid (GEA 6414) Cat No HY-B0335
Tolfenamic Acid (GEA 6414) is a non-steroidalanti-inflammatory and anti-cancer agentselectively inhibits with an of 1349COX-2 IC50
μM (353 μgmL) in LPS-treated (COX-2) canine DH82monocytemacrophage cells but shows no effect onCOX-1
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 10 g
Tolmetin sodium dihydrateCat No HY-B1489
Tolmetin sodium dihydrate is a non-steroidalantiinflammatory agent and acts as anon-selective inhibitorCOX
Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
TriflusalCat No HY-B0531
Triflusal irreversibly inhibits the production ofthromboxane-B2 in platelets by acetylatingcycloxygenase-1 Target COX Triflusal at 10 mM100 mM and 1 M decreases LDH efflux in rat brainslices after anoxiareoxygenation by 24 35 and49 respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Valdecoxib (SC 65872) Cat No HY-15762
Valdecoxib is a highly potent and selectiveinhibitor of with s of 5 nM and 140 μMCOX-2 IC50
for COX-2 and COX-1 respeceively Valdecoxib canbe used in the research of arthritis and pain
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Veratric acid (34-Dimethoxybenzoic acid) Cat No HY-N2007
Veratric acid (34-Dimethoxybenzoic acid) is anorally active phenolic compound derived fromvegetables and fruits has antioxidant andanti-inflammatory activities
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
XanthohumolCat No HY-N1067
Xanthohumol is one of the principal flavonoidsisolated from hops the inhibitor ofdiacylglycerol acetyltransferase ( ) DGAT COX-1and COX-2 and shows anti-cancer andanti-angiogenic activities
Purity 9968Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 25 mg
Zaltoprofen (CN100) Cat No HY-B0619
Zaltoprofen(CN100) is an inhibitor of COX fortreatment of arthritis
Purity 9909Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
[10]-ShogaolCat No HY-N2434
[10]-Shogaol is an antioxidant from Zingiber for human skin cell growth and aofficinale
migration enhancer [10]-Shogaol inhibits COX-2with an of 75 μM and has antiproliferationIC50
activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
16 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
[8]-ShogaolCat No HY-N2435
-Shogaol one of the pungent phenolic compounds inginger exhibits anti-platelet activity ( =5IC50
μM) and inhibits COX-2 ( =175 μM) -ShogaolIC50
induces apoptosis in human leukemia cells
Purity 9918Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-Humulene (Humulene α-Caryophyllene) Cat No HY-N6968
α-Humulene is a main constituent of Tanacetum L (Asteraceae) essential oil withvulgare
anti-inflammation (IC =15plusmn2 microgmL) α-Humulene50
inhibits and expressionCOX-2 iNOS
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-ChaconineCat No HY-129113
α-Chaconine isolated from a Solanum L cv Jayoung inhibits thetuberosum
expressions of and atCOX-2 IL-1β IL-6 TNF-αthe transcriptional level
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 17
Licofelone (ML-3000) Cat No HY-B1452
Licofelone (ML-3000) is a dual COX5-lipoxygenase inhibitor ( =021018 μM(5-LOX) IC50
respectively) for the treatment of osteoarthritisLicofelone exerts anti-inflammatory andanti-proliferative effects
Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
Lornoxicam (Chlortenoxicam Ro 13-9297 TS110) Cat No HY-B0367
Lornoxicam a COX-1 and COX-2 inhibitor is a newnonsteroidal anti-inflammatory drug (NSAID)Target COX Lornoxicam showed a balancedinhibition of COX-1-2 exhibiting the lowest IC50(0005 microM0008 microM) of the large panel ofNSAIDs tested
Purity 9831Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg
LoxoprofenCat No HY-B0578
Loxoprofen is a non-steroidal anti-inflammatorydrug Target COX Loxoprofen is a non-steroidalanti-inflammatory drug in the propionic acidderivatives group which also includes ibuprofenand naproxen among others
Purity 9882Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg
LY 178002Cat No HY-101579
LY 178002 is a potent inhibitor of 5-lipoxygenase with of 06 μM(5-LPO) phospholipase A2 IC50
for 5-lipoxygenase inhibits cellular productionof LTB4 by human polymorphonuclear leukocytes andshows relatively weak inhibition on cyclooxygenase
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
MavacoxibCat No HY-119447
Mavacoxib is a selective oral long-acting inhibitor and acyclooxygenase-2 (COX-2)
long-acting non-steroidal anti-inflammatory drug(NSAID) Mavacoxib is used to treat pain andinflammation associated with degenerative jointdisease in dogs
Purity 9983Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Mefenamic acidCat No HY-B0574
Mefenamic acid is a non-steroidalanti-inflammatory agent acting as a competitiveinhibitor of and with s of 40hCOX-1 hCOX-2 IC50
nM and 3 μM for hCOX-1 and hCOX-2 respectively
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
MeloxicamCat No HY-B0261
Meloxicam is a non-steroidal antiinflammatoryagent inhibits activity with s of 049COX IC50
microM and 366 microM for COX-2 and COX-1 respectively
Purity 9807Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Meloxicam D4Cat No HY-B0261S
Meloxicam D4 is deuterium labeled MeloxicamMeloxicam is a non-steroidal antiinflammatoryagent inhibits COX activity with IC s of 049 microM50
and 366 microM for COX-2 and COX-1 respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Metamizole sodium hydrateCat No HY-B1279
Metamizole sodium hydrate is a potent analgesicdrug that has been demonstrated to inhibitcyclooxygenase (COX)
Purity gt980Clinical Data LaunchedSize 500 mg
Methyl Salicylate (Wintergreen oil) Cat No HY-Y0189
Methyl Salicylate (Wintergreen oil) is a topicalanalgesic and anti-inflammatory agent Also usedas a pesticide a denaturant a fragranceingredient and a flavoring agent in food andtobacco products A systemic acquired resistance(SAR) signal in tobacco
Purity 9998Clinical Data No Development ReportedSize 10 mM times 1 mL 50 mg
10 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
N-trans-Feruloyltyramine (N-feruloyltyramine Moupinamide) Cat No HY-N2410
N-trans-Feruloyltyramine (N-feruloyltyramine) analkaloid from is an inhibitor of Piper nigru COX1and with potential antioxidant propertiesCOX2N-trans-Feruloyltyramine possessesanti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
Nabumetone (BRL14777) Cat No HY-B0559
Nabumetone is an orally active non-acidicanti-inflammatory agent acts as a potent andselective inhibitor and is the prodrug ofCOX-2the active metabolite 6MNA
Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Naproxen ((S)-Naproxen) Cat No HY-15030
Naproxen is a and inhibitor withCOX-1 COX-2s of 872 and 515 μM respectively in cellIC50
assay
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Naproxen etemesil (LT-NS 001 MX 1094) Cat No HY-19675
Naproxen etemesil is a lipophilic non-acidicinactive prodrug of naproxen that is hydrolysed topharmacologically active Naproxen once absorbedNaproxen is a and inhibitor withCOX-1 COX-2
s of 872 and 515 μM respectively in cellIC50
assay
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Naproxen sodiumCat No HY-15030A
Naproxen sodium is a and inhibitorCOX-1 COX-2with s of 872 and 515 μM respectively inIC50
cell assay
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) Cat No HY-N0722
Neochlorogenic acid is a natural polyphenoliccompound found in dried fruits and other plantsNeochlorogenic acid inhibits the production of
and Neochlorogenic acid suppressesTNF-α IL-1β protein expressioniNOS and COX-2
Purity 9946Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Nepafenac (AHR 9434 AL 6515) Cat No HY-17357
Nepafenac(AHR 9434 AL 6515 Nevanac) is aselective COX-2 inhibitor is prodrug of AmfenacIC50 value Target COX-2 Nepafenac is a NSAID(nonsteroidal anti inflammatory drug) that isroutinely used in opthamology to control painfollowing cataract surgery
Purity 9514Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Nepafenac D5 (AHR-9434 D5 AL-6515 D5) Cat No HY-17357S
Nepafenac D5 is the deuterium labeled Nepafenacwhich is a selective COX-2 inhibitor
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Nimesulide (R805) Cat No HY-B0363
Nimesulide is a selective inhibitor withCOX-2s of 70 nM-70 μM in a time-dependent mannerIC50
but it shows no effect on COX-1 (IC gt100 μM)50
Nimesulide has potent anti-inflammatory analgesicand antipyretic properties
Purity 9991Clinical Data Phase 4Size 10 mM times 1 mL 100 mg 500 mg
Nimesulide D5Cat No HY-B0363S
Nimesulide D5 is a deuterium labeled NimesulideNimesulide is a selective inhibitor withCOX-2
s of 70 nM-70 μM in a time-dependent mannerIC50
but it shows no effect on COX-1 (IC gt100 μM)50
Nimesulide has potent anti-inflammatory analgesicand antipyretic properties
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 11
Nitroaspirin (NCX 4016) Cat No HY-123823
Nitroaspirin (NCX 4016) is a nitric oxide (NO)donor and a nitro-derivative of Aspirin whichcombines with Nitroaspirin to inhibitcyclooxygenase
Purity gt98Clinical DataSize 1 mg 5 mg
Nitroflurbiprofen (HCT 1206 NO-flurbiprofen Nitroxybutyl flurbiprofen) Cat No HY-U00013
Nitroflurbiprofen is a ( )cyclooxygenase COXinhibitor with nitric oxide (NO)-donatingproperties modulates the increased intrahepaticvascular tone in portal hypertensive cirrhoticrats
Purity 9964Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
NS-398Cat No HY-13913
NS-398 is a non-steroidal an-inflammatory agentwith analgesic and antipyretic effects andselectively inhibits prostaglandin GH synthase2cyclooxygenase 2 ( ) activity with an COX-2 IC50
of 38 μM and has no effect on COX-1 at 100 μM
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Oxaprozin (Oxaprozinum Wy21743) Cat No HY-B0808
Oxaprozin is an inhibitor of both andCOX-1 with s of 22 μM and 36 μM for humanCOX-2 IC50
platelet COX-1 and IL-1-stimulated human synovialcell COX-2 respectively Oxaprozin also inhibitsthe activation of NF-κB
Purity 9963Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Oxaprozin D4 (Wy-21743 D4) Cat No HY-B0808S
Oxaprozin D4 is the deuterium labeled Oxaprozinwhich is a non-steroidal anti-inflammatory drug(NSAID)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
Pamicogrel (KBT3022) Cat No HY-U00175
Pamicogrel (KBT3022) is a ( )cyclooxygenase COXinhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Paradol ([6]-Gingerone [6]-Paradol) Cat No HY-14617
Paradol is a pungent phenolic substance found inginger and other Zingiberaceae plants Paradol isan effective inhibitor of tumor promotion in mouseskin carcinogenesis binds to cyclooxygenase
active site(COX)-2
Purity 9988Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Parecoxib (SC 69124) Cat No HY-17474
Parecoxib is a potent and selective COX-2inhibitor IC50 value Target COX-2 in vitro Theprodrug Parecoxib as well as its active metaboliteval have a specific affinity to the cannabinoid(CB) receptor measured in CB1-expressing HEK 293cells and rat brain tissue
Purity 9932Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Parecoxib Sodium (SC 69124A) Cat No HY-17474A
Parecoxib Sodium (SC 69124A) is a potent andselective COX-2 inhibitor
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
PelubiprofenCat No HY-12383
Pelubiprofen an orally active and non-steroidalanti-inflammatory drug is a member of the2-arylpropionic acid family and has relativelyselective effects on activityCOX-2
Purity gt98Clinical Data No Development ReportedSize 100 mg 250 mg 500 mg
12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Phenacetin (Acetophenetidin) Cat No HY-B0476
Phenacetin is a non-opioid analgesic withoutanti-inflammatory properties inhibits COX-3activity Target COX Phenacetin is apain-relieving and fever-reducing drug Phenacetinwas withdrawn from the Canadian market in June1973 due to concerns regarding nephropathy
Purity 9909Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
PhenylbutazoneCat No HY-B0230
Phenylbutazone is used as a non-steroidalanti-inflammatory agent for the treatment ofchronic pain including the symptoms of arthritisTarget Others Phenylbutazone was originally madeavailable for use in humans for the treatment ofrheumatoid arthritis and gout in 1949
Purity 9886Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg
Piroxicam (CP-16171) Cat No HY-B0253
Piroxicam (CP-16171) is a non-steroidalanti-inflammatory drugs acts as a inhibitorCOXwith s of 47 25 μM for human monocyte COX-1IC50
and COX-2 respectively
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g 10 g
Piroxicam D3 (CP-16171 D3) Cat No HY-B0253S
Piroxicam D3 (CP-16171 D3) is deuterium labeledPiroxicam Piroxicam is a non-steroidalanti-inflammatory drugs acts as a COX inhibitorwith IC s of 47 25 μM for human monocyte COX-150
and COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Prim-O-glucosylcimifuginCat No HY-N0635
Prim-O-glucosylcimifugin exerts anti-inflammatoryeffects through the inhibition of and iNOS COX-2expression by through regulating JAK2STAT3signaling
Purity 9976Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Propyphenazone (4-Isopropylantipyrine Isopropylphenazone) Cat No HY-A0273
Propyphenazone is a pyrazolone derivative withanti-inflammatory analgesic and antipyreticactivity Propyphenazone-based analogues asprodrugs and selective cyclooxygenase-2inhibitors
Purity 9994Clinical Data LaunchedSize 10 mM times 1 mL 250 mg
PsoralidinCat No HY-N0232
Psoralidin isolated from the seed of Psoralea is a dual inhibitor of andcorylifolia COX-2
regulates ionizing radiation (IR)-induced5-LOXpulmonary inflammationAnti-canceranti-bacterial and anti-inflammatory properties
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg
Rebamipide (OPC12759 Proamipide) Cat No HY-B0360
Rebamipide (OPC12759) is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Rebamipide D4 (OPC12759 D4 Proamipide D4) Cat No HY-B0360S
Rebamipide D4 (OPC12759 D4) is deuterium labeledRebamipide Rebamipide is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Revaprazan hydrochlorideCat No HY-N7067
Revaprazan hydrochloride is a novel acid pumpantagonist ( ) Revaprazan hydrochlorideAPAreduces expression and has significantCOX-2anti-inflammatory actions activities in H pyloriinfection
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 13
RHC 80267 (U-57908) Cat No HY-107416
RHC 80267 (U-57908) is a potent and selectiveinhibitor of (withdiacylglycerol lipase (DAGL)
of 4 μM in canine platelets) RHC-80267IC50
inhibits activity with an of 4cholinesterase IC50
μM thereby enhancing the relaxation evoked byacetylcholine
Purity gt98Clinical Data No Development ReportedSize 10 mM1m 10 mg 25 mg 50 mg 100 mg
Roburic acidCat No HY-N0481
Roburic acid a tetracyclic triterpenoid found in acts as an inhibitor ofGentiana macrophylla
with s of 5 and 9 μM for COX-1 andCOX IC50
COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Rofecoxib (MK 966) Cat No HY-17372
Rofecoxib is a potent specific and orally active inhibitor with s of 26 and 18 nM forCOX-2 IC50
human COX-2 in human osteosarcoma cells andChinese hamster ovary cells with a 1000-foldselectivity for COX-2 over human COX-1 (IC gt50
50 μM in U937 cells and gt 15 μM inhellip
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Rutaecarpine (Rutecarpine) Cat No HY-N0147
Rutaecarpine an alkaloid of isEvodia rutaecarpaan inhibitor of with an value of 028COX-2 IC50
μM
Purity 9911Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
RWJ 63556Cat No HY-U00022
RWJ 63556 is an orally active COX-2 inhibitor withselective5-lipoxygenase
anti-inflammatory activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
S-(+)-Ketoprofen ((S)-Ketoprofen Dexketoprofen) Cat No HY-B2137
S-(+)-Ketoprofen is a potent inhibitor of both and with s of 19 and 27 nMCOX-1 COX-2 IC50
respectively
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
S-(+)-Marmesin ((+)-Marmesin (S)-Marmesin) Cat No HY-N2176
S-(+)-Marmesin is a natural coumarin exhibiting dual inhibitory activityCOX-25-LOX
Purity 9904Clinical Data No Development ReportedSize 2 mg 5 mg 10 mg 25 mg 50 mg
S-2474Cat No HY-19212
S-2474 is an inhibitor of and COX-2 5-lipoxygenase with s of 11 nM and 27 μM for COX-2(5-LO) IC50
and COX-1 in human intact cells and used as anonsteroidal anti-inflammatory drug
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Salicin (D-(minus)-Salicin Salicoside) Cat No HY-N0149
Salicin is a natural inhibitorCOX
Purity 9960Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
Salicylic acid (2-Hydroxybenzoic acid) Cat No HY-B0167
Salicylic acid inhibits cyclo-oxygenase-2 ( )COX-2activity independently of transcription factor(NF-κB) activation
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
14 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SC-560Cat No HY-59105
SC-560 is a potent and selective inhibitorCOX-1with an of 9 nMIC50
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SC57666Cat No HY-U00129
SC57666 is a selective inhibitor with anCOX2 of 26 nMIC50
Purity 9894Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 20 mg
SC58451Cat No HY-U00239
SC58451 is a potent and selective Cox-2inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Sodium Salicylate (Salicylic acid sodium salt
2-Hydroxybenzoic acid sodium salt) Cat No HY-B0167A
Sodium Salicylate inhibits cyclo-oxygenase-2( ) activity independently of transcriptionCOX-2factor (NF-κB) activation
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
Sulindac (MK-231) Cat No HY-B0008
Sulindac (MK-231) is a non-steroidalantiinflammatory agent acts as a COX-2inhibitor and inhibits overexpression of COX-2
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
SyringaldehydeCat No HY-N1390
Syringaldehyde is a polyphenolic compoundbelonging to the group of flavonoids and is foundin different plant species like Manihot
and esculenta Magnolia officinalisSyringaldehyde moderately inhibits activityCOX-2with an of 35 μgmLIC50
Purity 9996Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Tenidap (CP-66248) Cat No HY-105028
Tenidap a non-steroidal anti-inflammatory drugis a selective inhibitor with valuesCOX-1 IC50
of 003 microM and 12 microM for COX-1 and COX-2respectively Tenidap has anti-inflammatory andantirheumatic properties Tenidap is also aspecific SLC26A3 inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tenoxicam (Ro-12-0068) Cat No HY-B0440
Tenoxicam (Ro-12-0068) an antiinflammatory agentwith analgesic and antipyretic properties
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) Cat No HY-112731
TFAP is a selective cyclooxygenase-1 (COX-1)inhibitor with an of 08 μMIC50
Purity 9997Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Thioflosulide (L-745337) Cat No HY-19217
Thioflosulide (L-745337) is a selective inhibitor with an ofcyclooxygenase-2 (COX2) IC50
23 nM and shows anti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
wwwMedChemExpresscom 15
Tilmacoxib (JTE522 JTP19605 RWJ57504) Cat No HY-U00197
Tilmacoxib (JTE522) is a highly selectivetime-dependent and irreversible human COX-2inhibitor with an of 85 nM in an enzymeIC50
assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Timegadine (SR1368) Cat No HY-100125
Timegadine a new antiinflammatory agent is foundto be a potent competitive inhibitor of
( ) and withcyclo-oxygenase COX lipo-oxygenases ranging from 5 nM (washed rabbit platelets)IC50
to 20 μM (rat brain) for COX and 100 μM forlipo-oxygenase both in the cytosol fractionhellip
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tolfenamic Acid (GEA 6414) Cat No HY-B0335
Tolfenamic Acid (GEA 6414) is a non-steroidalanti-inflammatory and anti-cancer agentselectively inhibits with an of 1349COX-2 IC50
μM (353 μgmL) in LPS-treated (COX-2) canine DH82monocytemacrophage cells but shows no effect onCOX-1
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 10 g
Tolmetin sodium dihydrateCat No HY-B1489
Tolmetin sodium dihydrate is a non-steroidalantiinflammatory agent and acts as anon-selective inhibitorCOX
Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
TriflusalCat No HY-B0531
Triflusal irreversibly inhibits the production ofthromboxane-B2 in platelets by acetylatingcycloxygenase-1 Target COX Triflusal at 10 mM100 mM and 1 M decreases LDH efflux in rat brainslices after anoxiareoxygenation by 24 35 and49 respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Valdecoxib (SC 65872) Cat No HY-15762
Valdecoxib is a highly potent and selectiveinhibitor of with s of 5 nM and 140 μMCOX-2 IC50
for COX-2 and COX-1 respeceively Valdecoxib canbe used in the research of arthritis and pain
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Veratric acid (34-Dimethoxybenzoic acid) Cat No HY-N2007
Veratric acid (34-Dimethoxybenzoic acid) is anorally active phenolic compound derived fromvegetables and fruits has antioxidant andanti-inflammatory activities
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
XanthohumolCat No HY-N1067
Xanthohumol is one of the principal flavonoidsisolated from hops the inhibitor ofdiacylglycerol acetyltransferase ( ) DGAT COX-1and COX-2 and shows anti-cancer andanti-angiogenic activities
Purity 9968Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 25 mg
Zaltoprofen (CN100) Cat No HY-B0619
Zaltoprofen(CN100) is an inhibitor of COX fortreatment of arthritis
Purity 9909Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
[10]-ShogaolCat No HY-N2434
[10]-Shogaol is an antioxidant from Zingiber for human skin cell growth and aofficinale
migration enhancer [10]-Shogaol inhibits COX-2with an of 75 μM and has antiproliferationIC50
activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
16 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
[8]-ShogaolCat No HY-N2435
-Shogaol one of the pungent phenolic compounds inginger exhibits anti-platelet activity ( =5IC50
μM) and inhibits COX-2 ( =175 μM) -ShogaolIC50
induces apoptosis in human leukemia cells
Purity 9918Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-Humulene (Humulene α-Caryophyllene) Cat No HY-N6968
α-Humulene is a main constituent of Tanacetum L (Asteraceae) essential oil withvulgare
anti-inflammation (IC =15plusmn2 microgmL) α-Humulene50
inhibits and expressionCOX-2 iNOS
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-ChaconineCat No HY-129113
α-Chaconine isolated from a Solanum L cv Jayoung inhibits thetuberosum
expressions of and atCOX-2 IL-1β IL-6 TNF-αthe transcriptional level
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 17
N-trans-Feruloyltyramine (N-feruloyltyramine Moupinamide) Cat No HY-N2410
N-trans-Feruloyltyramine (N-feruloyltyramine) analkaloid from is an inhibitor of Piper nigru COX1and with potential antioxidant propertiesCOX2N-trans-Feruloyltyramine possessesanti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
Nabumetone (BRL14777) Cat No HY-B0559
Nabumetone is an orally active non-acidicanti-inflammatory agent acts as a potent andselective inhibitor and is the prodrug ofCOX-2the active metabolite 6MNA
Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Naproxen ((S)-Naproxen) Cat No HY-15030
Naproxen is a and inhibitor withCOX-1 COX-2s of 872 and 515 μM respectively in cellIC50
assay
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Naproxen etemesil (LT-NS 001 MX 1094) Cat No HY-19675
Naproxen etemesil is a lipophilic non-acidicinactive prodrug of naproxen that is hydrolysed topharmacologically active Naproxen once absorbedNaproxen is a and inhibitor withCOX-1 COX-2
s of 872 and 515 μM respectively in cellIC50
assay
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Naproxen sodiumCat No HY-15030A
Naproxen sodium is a and inhibitorCOX-1 COX-2with s of 872 and 515 μM respectively inIC50
cell assay
Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 5 g 10 g
Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) Cat No HY-N0722
Neochlorogenic acid is a natural polyphenoliccompound found in dried fruits and other plantsNeochlorogenic acid inhibits the production of
and Neochlorogenic acid suppressesTNF-α IL-1β protein expressioniNOS and COX-2
Purity 9946Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Nepafenac (AHR 9434 AL 6515) Cat No HY-17357
Nepafenac(AHR 9434 AL 6515 Nevanac) is aselective COX-2 inhibitor is prodrug of AmfenacIC50 value Target COX-2 Nepafenac is a NSAID(nonsteroidal anti inflammatory drug) that isroutinely used in opthamology to control painfollowing cataract surgery
Purity 9514Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Nepafenac D5 (AHR-9434 D5 AL-6515 D5) Cat No HY-17357S
Nepafenac D5 is the deuterium labeled Nepafenacwhich is a selective COX-2 inhibitor
Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Nimesulide (R805) Cat No HY-B0363
Nimesulide is a selective inhibitor withCOX-2s of 70 nM-70 μM in a time-dependent mannerIC50
but it shows no effect on COX-1 (IC gt100 μM)50
Nimesulide has potent anti-inflammatory analgesicand antipyretic properties
Purity 9991Clinical Data Phase 4Size 10 mM times 1 mL 100 mg 500 mg
Nimesulide D5Cat No HY-B0363S
Nimesulide D5 is a deuterium labeled NimesulideNimesulide is a selective inhibitor withCOX-2
s of 70 nM-70 μM in a time-dependent mannerIC50
but it shows no effect on COX-1 (IC gt100 μM)50
Nimesulide has potent anti-inflammatory analgesicand antipyretic properties
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 11
Nitroaspirin (NCX 4016) Cat No HY-123823
Nitroaspirin (NCX 4016) is a nitric oxide (NO)donor and a nitro-derivative of Aspirin whichcombines with Nitroaspirin to inhibitcyclooxygenase
Purity gt98Clinical DataSize 1 mg 5 mg
Nitroflurbiprofen (HCT 1206 NO-flurbiprofen Nitroxybutyl flurbiprofen) Cat No HY-U00013
Nitroflurbiprofen is a ( )cyclooxygenase COXinhibitor with nitric oxide (NO)-donatingproperties modulates the increased intrahepaticvascular tone in portal hypertensive cirrhoticrats
Purity 9964Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
NS-398Cat No HY-13913
NS-398 is a non-steroidal an-inflammatory agentwith analgesic and antipyretic effects andselectively inhibits prostaglandin GH synthase2cyclooxygenase 2 ( ) activity with an COX-2 IC50
of 38 μM and has no effect on COX-1 at 100 μM
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Oxaprozin (Oxaprozinum Wy21743) Cat No HY-B0808
Oxaprozin is an inhibitor of both andCOX-1 with s of 22 μM and 36 μM for humanCOX-2 IC50
platelet COX-1 and IL-1-stimulated human synovialcell COX-2 respectively Oxaprozin also inhibitsthe activation of NF-κB
Purity 9963Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Oxaprozin D4 (Wy-21743 D4) Cat No HY-B0808S
Oxaprozin D4 is the deuterium labeled Oxaprozinwhich is a non-steroidal anti-inflammatory drug(NSAID)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
Pamicogrel (KBT3022) Cat No HY-U00175
Pamicogrel (KBT3022) is a ( )cyclooxygenase COXinhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Paradol ([6]-Gingerone [6]-Paradol) Cat No HY-14617
Paradol is a pungent phenolic substance found inginger and other Zingiberaceae plants Paradol isan effective inhibitor of tumor promotion in mouseskin carcinogenesis binds to cyclooxygenase
active site(COX)-2
Purity 9988Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Parecoxib (SC 69124) Cat No HY-17474
Parecoxib is a potent and selective COX-2inhibitor IC50 value Target COX-2 in vitro Theprodrug Parecoxib as well as its active metaboliteval have a specific affinity to the cannabinoid(CB) receptor measured in CB1-expressing HEK 293cells and rat brain tissue
Purity 9932Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Parecoxib Sodium (SC 69124A) Cat No HY-17474A
Parecoxib Sodium (SC 69124A) is a potent andselective COX-2 inhibitor
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
PelubiprofenCat No HY-12383
Pelubiprofen an orally active and non-steroidalanti-inflammatory drug is a member of the2-arylpropionic acid family and has relativelyselective effects on activityCOX-2
Purity gt98Clinical Data No Development ReportedSize 100 mg 250 mg 500 mg
12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Phenacetin (Acetophenetidin) Cat No HY-B0476
Phenacetin is a non-opioid analgesic withoutanti-inflammatory properties inhibits COX-3activity Target COX Phenacetin is apain-relieving and fever-reducing drug Phenacetinwas withdrawn from the Canadian market in June1973 due to concerns regarding nephropathy
Purity 9909Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
PhenylbutazoneCat No HY-B0230
Phenylbutazone is used as a non-steroidalanti-inflammatory agent for the treatment ofchronic pain including the symptoms of arthritisTarget Others Phenylbutazone was originally madeavailable for use in humans for the treatment ofrheumatoid arthritis and gout in 1949
Purity 9886Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg
Piroxicam (CP-16171) Cat No HY-B0253
Piroxicam (CP-16171) is a non-steroidalanti-inflammatory drugs acts as a inhibitorCOXwith s of 47 25 μM for human monocyte COX-1IC50
and COX-2 respectively
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g 10 g
Piroxicam D3 (CP-16171 D3) Cat No HY-B0253S
Piroxicam D3 (CP-16171 D3) is deuterium labeledPiroxicam Piroxicam is a non-steroidalanti-inflammatory drugs acts as a COX inhibitorwith IC s of 47 25 μM for human monocyte COX-150
and COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Prim-O-glucosylcimifuginCat No HY-N0635
Prim-O-glucosylcimifugin exerts anti-inflammatoryeffects through the inhibition of and iNOS COX-2expression by through regulating JAK2STAT3signaling
Purity 9976Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Propyphenazone (4-Isopropylantipyrine Isopropylphenazone) Cat No HY-A0273
Propyphenazone is a pyrazolone derivative withanti-inflammatory analgesic and antipyreticactivity Propyphenazone-based analogues asprodrugs and selective cyclooxygenase-2inhibitors
Purity 9994Clinical Data LaunchedSize 10 mM times 1 mL 250 mg
PsoralidinCat No HY-N0232
Psoralidin isolated from the seed of Psoralea is a dual inhibitor of andcorylifolia COX-2
regulates ionizing radiation (IR)-induced5-LOXpulmonary inflammationAnti-canceranti-bacterial and anti-inflammatory properties
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg
Rebamipide (OPC12759 Proamipide) Cat No HY-B0360
Rebamipide (OPC12759) is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Rebamipide D4 (OPC12759 D4 Proamipide D4) Cat No HY-B0360S
Rebamipide D4 (OPC12759 D4) is deuterium labeledRebamipide Rebamipide is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Revaprazan hydrochlorideCat No HY-N7067
Revaprazan hydrochloride is a novel acid pumpantagonist ( ) Revaprazan hydrochlorideAPAreduces expression and has significantCOX-2anti-inflammatory actions activities in H pyloriinfection
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 13
RHC 80267 (U-57908) Cat No HY-107416
RHC 80267 (U-57908) is a potent and selectiveinhibitor of (withdiacylglycerol lipase (DAGL)
of 4 μM in canine platelets) RHC-80267IC50
inhibits activity with an of 4cholinesterase IC50
μM thereby enhancing the relaxation evoked byacetylcholine
Purity gt98Clinical Data No Development ReportedSize 10 mM1m 10 mg 25 mg 50 mg 100 mg
Roburic acidCat No HY-N0481
Roburic acid a tetracyclic triterpenoid found in acts as an inhibitor ofGentiana macrophylla
with s of 5 and 9 μM for COX-1 andCOX IC50
COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Rofecoxib (MK 966) Cat No HY-17372
Rofecoxib is a potent specific and orally active inhibitor with s of 26 and 18 nM forCOX-2 IC50
human COX-2 in human osteosarcoma cells andChinese hamster ovary cells with a 1000-foldselectivity for COX-2 over human COX-1 (IC gt50
50 μM in U937 cells and gt 15 μM inhellip
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Rutaecarpine (Rutecarpine) Cat No HY-N0147
Rutaecarpine an alkaloid of isEvodia rutaecarpaan inhibitor of with an value of 028COX-2 IC50
μM
Purity 9911Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
RWJ 63556Cat No HY-U00022
RWJ 63556 is an orally active COX-2 inhibitor withselective5-lipoxygenase
anti-inflammatory activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
S-(+)-Ketoprofen ((S)-Ketoprofen Dexketoprofen) Cat No HY-B2137
S-(+)-Ketoprofen is a potent inhibitor of both and with s of 19 and 27 nMCOX-1 COX-2 IC50
respectively
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
S-(+)-Marmesin ((+)-Marmesin (S)-Marmesin) Cat No HY-N2176
S-(+)-Marmesin is a natural coumarin exhibiting dual inhibitory activityCOX-25-LOX
Purity 9904Clinical Data No Development ReportedSize 2 mg 5 mg 10 mg 25 mg 50 mg
S-2474Cat No HY-19212
S-2474 is an inhibitor of and COX-2 5-lipoxygenase with s of 11 nM and 27 μM for COX-2(5-LO) IC50
and COX-1 in human intact cells and used as anonsteroidal anti-inflammatory drug
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Salicin (D-(minus)-Salicin Salicoside) Cat No HY-N0149
Salicin is a natural inhibitorCOX
Purity 9960Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
Salicylic acid (2-Hydroxybenzoic acid) Cat No HY-B0167
Salicylic acid inhibits cyclo-oxygenase-2 ( )COX-2activity independently of transcription factor(NF-κB) activation
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
14 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SC-560Cat No HY-59105
SC-560 is a potent and selective inhibitorCOX-1with an of 9 nMIC50
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SC57666Cat No HY-U00129
SC57666 is a selective inhibitor with anCOX2 of 26 nMIC50
Purity 9894Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 20 mg
SC58451Cat No HY-U00239
SC58451 is a potent and selective Cox-2inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Sodium Salicylate (Salicylic acid sodium salt
2-Hydroxybenzoic acid sodium salt) Cat No HY-B0167A
Sodium Salicylate inhibits cyclo-oxygenase-2( ) activity independently of transcriptionCOX-2factor (NF-κB) activation
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
Sulindac (MK-231) Cat No HY-B0008
Sulindac (MK-231) is a non-steroidalantiinflammatory agent acts as a COX-2inhibitor and inhibits overexpression of COX-2
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
SyringaldehydeCat No HY-N1390
Syringaldehyde is a polyphenolic compoundbelonging to the group of flavonoids and is foundin different plant species like Manihot
and esculenta Magnolia officinalisSyringaldehyde moderately inhibits activityCOX-2with an of 35 μgmLIC50
Purity 9996Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Tenidap (CP-66248) Cat No HY-105028
Tenidap a non-steroidal anti-inflammatory drugis a selective inhibitor with valuesCOX-1 IC50
of 003 microM and 12 microM for COX-1 and COX-2respectively Tenidap has anti-inflammatory andantirheumatic properties Tenidap is also aspecific SLC26A3 inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tenoxicam (Ro-12-0068) Cat No HY-B0440
Tenoxicam (Ro-12-0068) an antiinflammatory agentwith analgesic and antipyretic properties
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) Cat No HY-112731
TFAP is a selective cyclooxygenase-1 (COX-1)inhibitor with an of 08 μMIC50
Purity 9997Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Thioflosulide (L-745337) Cat No HY-19217
Thioflosulide (L-745337) is a selective inhibitor with an ofcyclooxygenase-2 (COX2) IC50
23 nM and shows anti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
wwwMedChemExpresscom 15
Tilmacoxib (JTE522 JTP19605 RWJ57504) Cat No HY-U00197
Tilmacoxib (JTE522) is a highly selectivetime-dependent and irreversible human COX-2inhibitor with an of 85 nM in an enzymeIC50
assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Timegadine (SR1368) Cat No HY-100125
Timegadine a new antiinflammatory agent is foundto be a potent competitive inhibitor of
( ) and withcyclo-oxygenase COX lipo-oxygenases ranging from 5 nM (washed rabbit platelets)IC50
to 20 μM (rat brain) for COX and 100 μM forlipo-oxygenase both in the cytosol fractionhellip
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tolfenamic Acid (GEA 6414) Cat No HY-B0335
Tolfenamic Acid (GEA 6414) is a non-steroidalanti-inflammatory and anti-cancer agentselectively inhibits with an of 1349COX-2 IC50
μM (353 μgmL) in LPS-treated (COX-2) canine DH82monocytemacrophage cells but shows no effect onCOX-1
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 10 g
Tolmetin sodium dihydrateCat No HY-B1489
Tolmetin sodium dihydrate is a non-steroidalantiinflammatory agent and acts as anon-selective inhibitorCOX
Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
TriflusalCat No HY-B0531
Triflusal irreversibly inhibits the production ofthromboxane-B2 in platelets by acetylatingcycloxygenase-1 Target COX Triflusal at 10 mM100 mM and 1 M decreases LDH efflux in rat brainslices after anoxiareoxygenation by 24 35 and49 respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Valdecoxib (SC 65872) Cat No HY-15762
Valdecoxib is a highly potent and selectiveinhibitor of with s of 5 nM and 140 μMCOX-2 IC50
for COX-2 and COX-1 respeceively Valdecoxib canbe used in the research of arthritis and pain
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Veratric acid (34-Dimethoxybenzoic acid) Cat No HY-N2007
Veratric acid (34-Dimethoxybenzoic acid) is anorally active phenolic compound derived fromvegetables and fruits has antioxidant andanti-inflammatory activities
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
XanthohumolCat No HY-N1067
Xanthohumol is one of the principal flavonoidsisolated from hops the inhibitor ofdiacylglycerol acetyltransferase ( ) DGAT COX-1and COX-2 and shows anti-cancer andanti-angiogenic activities
Purity 9968Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 25 mg
Zaltoprofen (CN100) Cat No HY-B0619
Zaltoprofen(CN100) is an inhibitor of COX fortreatment of arthritis
Purity 9909Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
[10]-ShogaolCat No HY-N2434
[10]-Shogaol is an antioxidant from Zingiber for human skin cell growth and aofficinale
migration enhancer [10]-Shogaol inhibits COX-2with an of 75 μM and has antiproliferationIC50
activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
16 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
[8]-ShogaolCat No HY-N2435
-Shogaol one of the pungent phenolic compounds inginger exhibits anti-platelet activity ( =5IC50
μM) and inhibits COX-2 ( =175 μM) -ShogaolIC50
induces apoptosis in human leukemia cells
Purity 9918Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-Humulene (Humulene α-Caryophyllene) Cat No HY-N6968
α-Humulene is a main constituent of Tanacetum L (Asteraceae) essential oil withvulgare
anti-inflammation (IC =15plusmn2 microgmL) α-Humulene50
inhibits and expressionCOX-2 iNOS
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-ChaconineCat No HY-129113
α-Chaconine isolated from a Solanum L cv Jayoung inhibits thetuberosum
expressions of and atCOX-2 IL-1β IL-6 TNF-αthe transcriptional level
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 17
Nitroaspirin (NCX 4016) Cat No HY-123823
Nitroaspirin (NCX 4016) is a nitric oxide (NO)donor and a nitro-derivative of Aspirin whichcombines with Nitroaspirin to inhibitcyclooxygenase
Purity gt98Clinical DataSize 1 mg 5 mg
Nitroflurbiprofen (HCT 1206 NO-flurbiprofen Nitroxybutyl flurbiprofen) Cat No HY-U00013
Nitroflurbiprofen is a ( )cyclooxygenase COXinhibitor with nitric oxide (NO)-donatingproperties modulates the increased intrahepaticvascular tone in portal hypertensive cirrhoticrats
Purity 9964Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
NS-398Cat No HY-13913
NS-398 is a non-steroidal an-inflammatory agentwith analgesic and antipyretic effects andselectively inhibits prostaglandin GH synthase2cyclooxygenase 2 ( ) activity with an COX-2 IC50
of 38 μM and has no effect on COX-1 at 100 μM
Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Oxaprozin (Oxaprozinum Wy21743) Cat No HY-B0808
Oxaprozin is an inhibitor of both andCOX-1 with s of 22 μM and 36 μM for humanCOX-2 IC50
platelet COX-1 and IL-1-stimulated human synovialcell COX-2 respectively Oxaprozin also inhibitsthe activation of NF-κB
Purity 9963Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Oxaprozin D4 (Wy-21743 D4) Cat No HY-B0808S
Oxaprozin D4 is the deuterium labeled Oxaprozinwhich is a non-steroidal anti-inflammatory drug(NSAID)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
Pamicogrel (KBT3022) Cat No HY-U00175
Pamicogrel (KBT3022) is a ( )cyclooxygenase COXinhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Paradol ([6]-Gingerone [6]-Paradol) Cat No HY-14617
Paradol is a pungent phenolic substance found inginger and other Zingiberaceae plants Paradol isan effective inhibitor of tumor promotion in mouseskin carcinogenesis binds to cyclooxygenase
active site(COX)-2
Purity 9988Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Parecoxib (SC 69124) Cat No HY-17474
Parecoxib is a potent and selective COX-2inhibitor IC50 value Target COX-2 in vitro Theprodrug Parecoxib as well as its active metaboliteval have a specific affinity to the cannabinoid(CB) receptor measured in CB1-expressing HEK 293cells and rat brain tissue
Purity 9932Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Parecoxib Sodium (SC 69124A) Cat No HY-17474A
Parecoxib Sodium (SC 69124A) is a potent andselective COX-2 inhibitor
Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
PelubiprofenCat No HY-12383
Pelubiprofen an orally active and non-steroidalanti-inflammatory drug is a member of the2-arylpropionic acid family and has relativelyselective effects on activityCOX-2
Purity gt98Clinical Data No Development ReportedSize 100 mg 250 mg 500 mg
12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Phenacetin (Acetophenetidin) Cat No HY-B0476
Phenacetin is a non-opioid analgesic withoutanti-inflammatory properties inhibits COX-3activity Target COX Phenacetin is apain-relieving and fever-reducing drug Phenacetinwas withdrawn from the Canadian market in June1973 due to concerns regarding nephropathy
Purity 9909Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
PhenylbutazoneCat No HY-B0230
Phenylbutazone is used as a non-steroidalanti-inflammatory agent for the treatment ofchronic pain including the symptoms of arthritisTarget Others Phenylbutazone was originally madeavailable for use in humans for the treatment ofrheumatoid arthritis and gout in 1949
Purity 9886Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg
Piroxicam (CP-16171) Cat No HY-B0253
Piroxicam (CP-16171) is a non-steroidalanti-inflammatory drugs acts as a inhibitorCOXwith s of 47 25 μM for human monocyte COX-1IC50
and COX-2 respectively
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g 10 g
Piroxicam D3 (CP-16171 D3) Cat No HY-B0253S
Piroxicam D3 (CP-16171 D3) is deuterium labeledPiroxicam Piroxicam is a non-steroidalanti-inflammatory drugs acts as a COX inhibitorwith IC s of 47 25 μM for human monocyte COX-150
and COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Prim-O-glucosylcimifuginCat No HY-N0635
Prim-O-glucosylcimifugin exerts anti-inflammatoryeffects through the inhibition of and iNOS COX-2expression by through regulating JAK2STAT3signaling
Purity 9976Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Propyphenazone (4-Isopropylantipyrine Isopropylphenazone) Cat No HY-A0273
Propyphenazone is a pyrazolone derivative withanti-inflammatory analgesic and antipyreticactivity Propyphenazone-based analogues asprodrugs and selective cyclooxygenase-2inhibitors
Purity 9994Clinical Data LaunchedSize 10 mM times 1 mL 250 mg
PsoralidinCat No HY-N0232
Psoralidin isolated from the seed of Psoralea is a dual inhibitor of andcorylifolia COX-2
regulates ionizing radiation (IR)-induced5-LOXpulmonary inflammationAnti-canceranti-bacterial and anti-inflammatory properties
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg
Rebamipide (OPC12759 Proamipide) Cat No HY-B0360
Rebamipide (OPC12759) is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Rebamipide D4 (OPC12759 D4 Proamipide D4) Cat No HY-B0360S
Rebamipide D4 (OPC12759 D4) is deuterium labeledRebamipide Rebamipide is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Revaprazan hydrochlorideCat No HY-N7067
Revaprazan hydrochloride is a novel acid pumpantagonist ( ) Revaprazan hydrochlorideAPAreduces expression and has significantCOX-2anti-inflammatory actions activities in H pyloriinfection
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 13
RHC 80267 (U-57908) Cat No HY-107416
RHC 80267 (U-57908) is a potent and selectiveinhibitor of (withdiacylglycerol lipase (DAGL)
of 4 μM in canine platelets) RHC-80267IC50
inhibits activity with an of 4cholinesterase IC50
μM thereby enhancing the relaxation evoked byacetylcholine
Purity gt98Clinical Data No Development ReportedSize 10 mM1m 10 mg 25 mg 50 mg 100 mg
Roburic acidCat No HY-N0481
Roburic acid a tetracyclic triterpenoid found in acts as an inhibitor ofGentiana macrophylla
with s of 5 and 9 μM for COX-1 andCOX IC50
COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Rofecoxib (MK 966) Cat No HY-17372
Rofecoxib is a potent specific and orally active inhibitor with s of 26 and 18 nM forCOX-2 IC50
human COX-2 in human osteosarcoma cells andChinese hamster ovary cells with a 1000-foldselectivity for COX-2 over human COX-1 (IC gt50
50 μM in U937 cells and gt 15 μM inhellip
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Rutaecarpine (Rutecarpine) Cat No HY-N0147
Rutaecarpine an alkaloid of isEvodia rutaecarpaan inhibitor of with an value of 028COX-2 IC50
μM
Purity 9911Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
RWJ 63556Cat No HY-U00022
RWJ 63556 is an orally active COX-2 inhibitor withselective5-lipoxygenase
anti-inflammatory activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
S-(+)-Ketoprofen ((S)-Ketoprofen Dexketoprofen) Cat No HY-B2137
S-(+)-Ketoprofen is a potent inhibitor of both and with s of 19 and 27 nMCOX-1 COX-2 IC50
respectively
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
S-(+)-Marmesin ((+)-Marmesin (S)-Marmesin) Cat No HY-N2176
S-(+)-Marmesin is a natural coumarin exhibiting dual inhibitory activityCOX-25-LOX
Purity 9904Clinical Data No Development ReportedSize 2 mg 5 mg 10 mg 25 mg 50 mg
S-2474Cat No HY-19212
S-2474 is an inhibitor of and COX-2 5-lipoxygenase with s of 11 nM and 27 μM for COX-2(5-LO) IC50
and COX-1 in human intact cells and used as anonsteroidal anti-inflammatory drug
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Salicin (D-(minus)-Salicin Salicoside) Cat No HY-N0149
Salicin is a natural inhibitorCOX
Purity 9960Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
Salicylic acid (2-Hydroxybenzoic acid) Cat No HY-B0167
Salicylic acid inhibits cyclo-oxygenase-2 ( )COX-2activity independently of transcription factor(NF-κB) activation
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
14 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SC-560Cat No HY-59105
SC-560 is a potent and selective inhibitorCOX-1with an of 9 nMIC50
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SC57666Cat No HY-U00129
SC57666 is a selective inhibitor with anCOX2 of 26 nMIC50
Purity 9894Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 20 mg
SC58451Cat No HY-U00239
SC58451 is a potent and selective Cox-2inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Sodium Salicylate (Salicylic acid sodium salt
2-Hydroxybenzoic acid sodium salt) Cat No HY-B0167A
Sodium Salicylate inhibits cyclo-oxygenase-2( ) activity independently of transcriptionCOX-2factor (NF-κB) activation
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
Sulindac (MK-231) Cat No HY-B0008
Sulindac (MK-231) is a non-steroidalantiinflammatory agent acts as a COX-2inhibitor and inhibits overexpression of COX-2
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
SyringaldehydeCat No HY-N1390
Syringaldehyde is a polyphenolic compoundbelonging to the group of flavonoids and is foundin different plant species like Manihot
and esculenta Magnolia officinalisSyringaldehyde moderately inhibits activityCOX-2with an of 35 μgmLIC50
Purity 9996Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Tenidap (CP-66248) Cat No HY-105028
Tenidap a non-steroidal anti-inflammatory drugis a selective inhibitor with valuesCOX-1 IC50
of 003 microM and 12 microM for COX-1 and COX-2respectively Tenidap has anti-inflammatory andantirheumatic properties Tenidap is also aspecific SLC26A3 inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tenoxicam (Ro-12-0068) Cat No HY-B0440
Tenoxicam (Ro-12-0068) an antiinflammatory agentwith analgesic and antipyretic properties
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) Cat No HY-112731
TFAP is a selective cyclooxygenase-1 (COX-1)inhibitor with an of 08 μMIC50
Purity 9997Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Thioflosulide (L-745337) Cat No HY-19217
Thioflosulide (L-745337) is a selective inhibitor with an ofcyclooxygenase-2 (COX2) IC50
23 nM and shows anti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
wwwMedChemExpresscom 15
Tilmacoxib (JTE522 JTP19605 RWJ57504) Cat No HY-U00197
Tilmacoxib (JTE522) is a highly selectivetime-dependent and irreversible human COX-2inhibitor with an of 85 nM in an enzymeIC50
assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Timegadine (SR1368) Cat No HY-100125
Timegadine a new antiinflammatory agent is foundto be a potent competitive inhibitor of
( ) and withcyclo-oxygenase COX lipo-oxygenases ranging from 5 nM (washed rabbit platelets)IC50
to 20 μM (rat brain) for COX and 100 μM forlipo-oxygenase both in the cytosol fractionhellip
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tolfenamic Acid (GEA 6414) Cat No HY-B0335
Tolfenamic Acid (GEA 6414) is a non-steroidalanti-inflammatory and anti-cancer agentselectively inhibits with an of 1349COX-2 IC50
μM (353 μgmL) in LPS-treated (COX-2) canine DH82monocytemacrophage cells but shows no effect onCOX-1
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 10 g
Tolmetin sodium dihydrateCat No HY-B1489
Tolmetin sodium dihydrate is a non-steroidalantiinflammatory agent and acts as anon-selective inhibitorCOX
Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
TriflusalCat No HY-B0531
Triflusal irreversibly inhibits the production ofthromboxane-B2 in platelets by acetylatingcycloxygenase-1 Target COX Triflusal at 10 mM100 mM and 1 M decreases LDH efflux in rat brainslices after anoxiareoxygenation by 24 35 and49 respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Valdecoxib (SC 65872) Cat No HY-15762
Valdecoxib is a highly potent and selectiveinhibitor of with s of 5 nM and 140 μMCOX-2 IC50
for COX-2 and COX-1 respeceively Valdecoxib canbe used in the research of arthritis and pain
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Veratric acid (34-Dimethoxybenzoic acid) Cat No HY-N2007
Veratric acid (34-Dimethoxybenzoic acid) is anorally active phenolic compound derived fromvegetables and fruits has antioxidant andanti-inflammatory activities
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
XanthohumolCat No HY-N1067
Xanthohumol is one of the principal flavonoidsisolated from hops the inhibitor ofdiacylglycerol acetyltransferase ( ) DGAT COX-1and COX-2 and shows anti-cancer andanti-angiogenic activities
Purity 9968Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 25 mg
Zaltoprofen (CN100) Cat No HY-B0619
Zaltoprofen(CN100) is an inhibitor of COX fortreatment of arthritis
Purity 9909Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
[10]-ShogaolCat No HY-N2434
[10]-Shogaol is an antioxidant from Zingiber for human skin cell growth and aofficinale
migration enhancer [10]-Shogaol inhibits COX-2with an of 75 μM and has antiproliferationIC50
activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
16 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
[8]-ShogaolCat No HY-N2435
-Shogaol one of the pungent phenolic compounds inginger exhibits anti-platelet activity ( =5IC50
μM) and inhibits COX-2 ( =175 μM) -ShogaolIC50
induces apoptosis in human leukemia cells
Purity 9918Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-Humulene (Humulene α-Caryophyllene) Cat No HY-N6968
α-Humulene is a main constituent of Tanacetum L (Asteraceae) essential oil withvulgare
anti-inflammation (IC =15plusmn2 microgmL) α-Humulene50
inhibits and expressionCOX-2 iNOS
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-ChaconineCat No HY-129113
α-Chaconine isolated from a Solanum L cv Jayoung inhibits thetuberosum
expressions of and atCOX-2 IL-1β IL-6 TNF-αthe transcriptional level
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 17
Phenacetin (Acetophenetidin) Cat No HY-B0476
Phenacetin is a non-opioid analgesic withoutanti-inflammatory properties inhibits COX-3activity Target COX Phenacetin is apain-relieving and fever-reducing drug Phenacetinwas withdrawn from the Canadian market in June1973 due to concerns regarding nephropathy
Purity 9909Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
PhenylbutazoneCat No HY-B0230
Phenylbutazone is used as a non-steroidalanti-inflammatory agent for the treatment ofchronic pain including the symptoms of arthritisTarget Others Phenylbutazone was originally madeavailable for use in humans for the treatment ofrheumatoid arthritis and gout in 1949
Purity 9886Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg
Piroxicam (CP-16171) Cat No HY-B0253
Piroxicam (CP-16171) is a non-steroidalanti-inflammatory drugs acts as a inhibitorCOXwith s of 47 25 μM for human monocyte COX-1IC50
and COX-2 respectively
Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g 10 g
Piroxicam D3 (CP-16171 D3) Cat No HY-B0253S
Piroxicam D3 (CP-16171 D3) is deuterium labeledPiroxicam Piroxicam is a non-steroidalanti-inflammatory drugs acts as a COX inhibitorwith IC s of 47 25 μM for human monocyte COX-150
and COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Prim-O-glucosylcimifuginCat No HY-N0635
Prim-O-glucosylcimifugin exerts anti-inflammatoryeffects through the inhibition of and iNOS COX-2expression by through regulating JAK2STAT3signaling
Purity 9976Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Propyphenazone (4-Isopropylantipyrine Isopropylphenazone) Cat No HY-A0273
Propyphenazone is a pyrazolone derivative withanti-inflammatory analgesic and antipyreticactivity Propyphenazone-based analogues asprodrugs and selective cyclooxygenase-2inhibitors
Purity 9994Clinical Data LaunchedSize 10 mM times 1 mL 250 mg
PsoralidinCat No HY-N0232
Psoralidin isolated from the seed of Psoralea is a dual inhibitor of andcorylifolia COX-2
regulates ionizing radiation (IR)-induced5-LOXpulmonary inflammationAnti-canceranti-bacterial and anti-inflammatory properties
Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg
Rebamipide (OPC12759 Proamipide) Cat No HY-B0360
Rebamipide (OPC12759) is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
Rebamipide D4 (OPC12759 D4 Proamipide D4) Cat No HY-B0360S
Rebamipide D4 (OPC12759 D4) is deuterium labeledRebamipide Rebamipide is a mucoprotective agentRebamipide induces expression increasesCOX-2
levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Revaprazan hydrochlorideCat No HY-N7067
Revaprazan hydrochloride is a novel acid pumpantagonist ( ) Revaprazan hydrochlorideAPAreduces expression and has significantCOX-2anti-inflammatory actions activities in H pyloriinfection
Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 13
RHC 80267 (U-57908) Cat No HY-107416
RHC 80267 (U-57908) is a potent and selectiveinhibitor of (withdiacylglycerol lipase (DAGL)
of 4 μM in canine platelets) RHC-80267IC50
inhibits activity with an of 4cholinesterase IC50
μM thereby enhancing the relaxation evoked byacetylcholine
Purity gt98Clinical Data No Development ReportedSize 10 mM1m 10 mg 25 mg 50 mg 100 mg
Roburic acidCat No HY-N0481
Roburic acid a tetracyclic triterpenoid found in acts as an inhibitor ofGentiana macrophylla
with s of 5 and 9 μM for COX-1 andCOX IC50
COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Rofecoxib (MK 966) Cat No HY-17372
Rofecoxib is a potent specific and orally active inhibitor with s of 26 and 18 nM forCOX-2 IC50
human COX-2 in human osteosarcoma cells andChinese hamster ovary cells with a 1000-foldselectivity for COX-2 over human COX-1 (IC gt50
50 μM in U937 cells and gt 15 μM inhellip
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Rutaecarpine (Rutecarpine) Cat No HY-N0147
Rutaecarpine an alkaloid of isEvodia rutaecarpaan inhibitor of with an value of 028COX-2 IC50
μM
Purity 9911Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
RWJ 63556Cat No HY-U00022
RWJ 63556 is an orally active COX-2 inhibitor withselective5-lipoxygenase
anti-inflammatory activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
S-(+)-Ketoprofen ((S)-Ketoprofen Dexketoprofen) Cat No HY-B2137
S-(+)-Ketoprofen is a potent inhibitor of both and with s of 19 and 27 nMCOX-1 COX-2 IC50
respectively
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
S-(+)-Marmesin ((+)-Marmesin (S)-Marmesin) Cat No HY-N2176
S-(+)-Marmesin is a natural coumarin exhibiting dual inhibitory activityCOX-25-LOX
Purity 9904Clinical Data No Development ReportedSize 2 mg 5 mg 10 mg 25 mg 50 mg
S-2474Cat No HY-19212
S-2474 is an inhibitor of and COX-2 5-lipoxygenase with s of 11 nM and 27 μM for COX-2(5-LO) IC50
and COX-1 in human intact cells and used as anonsteroidal anti-inflammatory drug
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Salicin (D-(minus)-Salicin Salicoside) Cat No HY-N0149
Salicin is a natural inhibitorCOX
Purity 9960Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
Salicylic acid (2-Hydroxybenzoic acid) Cat No HY-B0167
Salicylic acid inhibits cyclo-oxygenase-2 ( )COX-2activity independently of transcription factor(NF-κB) activation
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
14 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SC-560Cat No HY-59105
SC-560 is a potent and selective inhibitorCOX-1with an of 9 nMIC50
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SC57666Cat No HY-U00129
SC57666 is a selective inhibitor with anCOX2 of 26 nMIC50
Purity 9894Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 20 mg
SC58451Cat No HY-U00239
SC58451 is a potent and selective Cox-2inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Sodium Salicylate (Salicylic acid sodium salt
2-Hydroxybenzoic acid sodium salt) Cat No HY-B0167A
Sodium Salicylate inhibits cyclo-oxygenase-2( ) activity independently of transcriptionCOX-2factor (NF-κB) activation
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
Sulindac (MK-231) Cat No HY-B0008
Sulindac (MK-231) is a non-steroidalantiinflammatory agent acts as a COX-2inhibitor and inhibits overexpression of COX-2
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
SyringaldehydeCat No HY-N1390
Syringaldehyde is a polyphenolic compoundbelonging to the group of flavonoids and is foundin different plant species like Manihot
and esculenta Magnolia officinalisSyringaldehyde moderately inhibits activityCOX-2with an of 35 μgmLIC50
Purity 9996Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Tenidap (CP-66248) Cat No HY-105028
Tenidap a non-steroidal anti-inflammatory drugis a selective inhibitor with valuesCOX-1 IC50
of 003 microM and 12 microM for COX-1 and COX-2respectively Tenidap has anti-inflammatory andantirheumatic properties Tenidap is also aspecific SLC26A3 inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tenoxicam (Ro-12-0068) Cat No HY-B0440
Tenoxicam (Ro-12-0068) an antiinflammatory agentwith analgesic and antipyretic properties
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) Cat No HY-112731
TFAP is a selective cyclooxygenase-1 (COX-1)inhibitor with an of 08 μMIC50
Purity 9997Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Thioflosulide (L-745337) Cat No HY-19217
Thioflosulide (L-745337) is a selective inhibitor with an ofcyclooxygenase-2 (COX2) IC50
23 nM and shows anti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
wwwMedChemExpresscom 15
Tilmacoxib (JTE522 JTP19605 RWJ57504) Cat No HY-U00197
Tilmacoxib (JTE522) is a highly selectivetime-dependent and irreversible human COX-2inhibitor with an of 85 nM in an enzymeIC50
assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Timegadine (SR1368) Cat No HY-100125
Timegadine a new antiinflammatory agent is foundto be a potent competitive inhibitor of
( ) and withcyclo-oxygenase COX lipo-oxygenases ranging from 5 nM (washed rabbit platelets)IC50
to 20 μM (rat brain) for COX and 100 μM forlipo-oxygenase both in the cytosol fractionhellip
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tolfenamic Acid (GEA 6414) Cat No HY-B0335
Tolfenamic Acid (GEA 6414) is a non-steroidalanti-inflammatory and anti-cancer agentselectively inhibits with an of 1349COX-2 IC50
μM (353 μgmL) in LPS-treated (COX-2) canine DH82monocytemacrophage cells but shows no effect onCOX-1
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 10 g
Tolmetin sodium dihydrateCat No HY-B1489
Tolmetin sodium dihydrate is a non-steroidalantiinflammatory agent and acts as anon-selective inhibitorCOX
Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
TriflusalCat No HY-B0531
Triflusal irreversibly inhibits the production ofthromboxane-B2 in platelets by acetylatingcycloxygenase-1 Target COX Triflusal at 10 mM100 mM and 1 M decreases LDH efflux in rat brainslices after anoxiareoxygenation by 24 35 and49 respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Valdecoxib (SC 65872) Cat No HY-15762
Valdecoxib is a highly potent and selectiveinhibitor of with s of 5 nM and 140 μMCOX-2 IC50
for COX-2 and COX-1 respeceively Valdecoxib canbe used in the research of arthritis and pain
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Veratric acid (34-Dimethoxybenzoic acid) Cat No HY-N2007
Veratric acid (34-Dimethoxybenzoic acid) is anorally active phenolic compound derived fromvegetables and fruits has antioxidant andanti-inflammatory activities
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
XanthohumolCat No HY-N1067
Xanthohumol is one of the principal flavonoidsisolated from hops the inhibitor ofdiacylglycerol acetyltransferase ( ) DGAT COX-1and COX-2 and shows anti-cancer andanti-angiogenic activities
Purity 9968Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 25 mg
Zaltoprofen (CN100) Cat No HY-B0619
Zaltoprofen(CN100) is an inhibitor of COX fortreatment of arthritis
Purity 9909Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
[10]-ShogaolCat No HY-N2434
[10]-Shogaol is an antioxidant from Zingiber for human skin cell growth and aofficinale
migration enhancer [10]-Shogaol inhibits COX-2with an of 75 μM and has antiproliferationIC50
activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
16 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
[8]-ShogaolCat No HY-N2435
-Shogaol one of the pungent phenolic compounds inginger exhibits anti-platelet activity ( =5IC50
μM) and inhibits COX-2 ( =175 μM) -ShogaolIC50
induces apoptosis in human leukemia cells
Purity 9918Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-Humulene (Humulene α-Caryophyllene) Cat No HY-N6968
α-Humulene is a main constituent of Tanacetum L (Asteraceae) essential oil withvulgare
anti-inflammation (IC =15plusmn2 microgmL) α-Humulene50
inhibits and expressionCOX-2 iNOS
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-ChaconineCat No HY-129113
α-Chaconine isolated from a Solanum L cv Jayoung inhibits thetuberosum
expressions of and atCOX-2 IL-1β IL-6 TNF-αthe transcriptional level
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 17
RHC 80267 (U-57908) Cat No HY-107416
RHC 80267 (U-57908) is a potent and selectiveinhibitor of (withdiacylglycerol lipase (DAGL)
of 4 μM in canine platelets) RHC-80267IC50
inhibits activity with an of 4cholinesterase IC50
μM thereby enhancing the relaxation evoked byacetylcholine
Purity gt98Clinical Data No Development ReportedSize 10 mM1m 10 mg 25 mg 50 mg 100 mg
Roburic acidCat No HY-N0481
Roburic acid a tetracyclic triterpenoid found in acts as an inhibitor ofGentiana macrophylla
with s of 5 and 9 μM for COX-1 andCOX IC50
COX-2 respectively
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Rofecoxib (MK 966) Cat No HY-17372
Rofecoxib is a potent specific and orally active inhibitor with s of 26 and 18 nM forCOX-2 IC50
human COX-2 in human osteosarcoma cells andChinese hamster ovary cells with a 1000-foldselectivity for COX-2 over human COX-1 (IC gt50
50 μM in U937 cells and gt 15 μM inhellip
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Rutaecarpine (Rutecarpine) Cat No HY-N0147
Rutaecarpine an alkaloid of isEvodia rutaecarpaan inhibitor of with an value of 028COX-2 IC50
μM
Purity 9911Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
RWJ 63556Cat No HY-U00022
RWJ 63556 is an orally active COX-2 inhibitor withselective5-lipoxygenase
anti-inflammatory activities
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
S-(+)-Ketoprofen ((S)-Ketoprofen Dexketoprofen) Cat No HY-B2137
S-(+)-Ketoprofen is a potent inhibitor of both and with s of 19 and 27 nMCOX-1 COX-2 IC50
respectively
Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
S-(+)-Marmesin ((+)-Marmesin (S)-Marmesin) Cat No HY-N2176
S-(+)-Marmesin is a natural coumarin exhibiting dual inhibitory activityCOX-25-LOX
Purity 9904Clinical Data No Development ReportedSize 2 mg 5 mg 10 mg 25 mg 50 mg
S-2474Cat No HY-19212
S-2474 is an inhibitor of and COX-2 5-lipoxygenase with s of 11 nM and 27 μM for COX-2(5-LO) IC50
and COX-1 in human intact cells and used as anonsteroidal anti-inflammatory drug
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Salicin (D-(minus)-Salicin Salicoside) Cat No HY-N0149
Salicin is a natural inhibitorCOX
Purity 9960Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g
Salicylic acid (2-Hydroxybenzoic acid) Cat No HY-B0167
Salicylic acid inhibits cyclo-oxygenase-2 ( )COX-2activity independently of transcription factor(NF-κB) activation
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
14 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SC-560Cat No HY-59105
SC-560 is a potent and selective inhibitorCOX-1with an of 9 nMIC50
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SC57666Cat No HY-U00129
SC57666 is a selective inhibitor with anCOX2 of 26 nMIC50
Purity 9894Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 20 mg
SC58451Cat No HY-U00239
SC58451 is a potent and selective Cox-2inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Sodium Salicylate (Salicylic acid sodium salt
2-Hydroxybenzoic acid sodium salt) Cat No HY-B0167A
Sodium Salicylate inhibits cyclo-oxygenase-2( ) activity independently of transcriptionCOX-2factor (NF-κB) activation
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
Sulindac (MK-231) Cat No HY-B0008
Sulindac (MK-231) is a non-steroidalantiinflammatory agent acts as a COX-2inhibitor and inhibits overexpression of COX-2
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
SyringaldehydeCat No HY-N1390
Syringaldehyde is a polyphenolic compoundbelonging to the group of flavonoids and is foundin different plant species like Manihot
and esculenta Magnolia officinalisSyringaldehyde moderately inhibits activityCOX-2with an of 35 μgmLIC50
Purity 9996Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Tenidap (CP-66248) Cat No HY-105028
Tenidap a non-steroidal anti-inflammatory drugis a selective inhibitor with valuesCOX-1 IC50
of 003 microM and 12 microM for COX-1 and COX-2respectively Tenidap has anti-inflammatory andantirheumatic properties Tenidap is also aspecific SLC26A3 inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tenoxicam (Ro-12-0068) Cat No HY-B0440
Tenoxicam (Ro-12-0068) an antiinflammatory agentwith analgesic and antipyretic properties
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) Cat No HY-112731
TFAP is a selective cyclooxygenase-1 (COX-1)inhibitor with an of 08 μMIC50
Purity 9997Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Thioflosulide (L-745337) Cat No HY-19217
Thioflosulide (L-745337) is a selective inhibitor with an ofcyclooxygenase-2 (COX2) IC50
23 nM and shows anti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
wwwMedChemExpresscom 15
Tilmacoxib (JTE522 JTP19605 RWJ57504) Cat No HY-U00197
Tilmacoxib (JTE522) is a highly selectivetime-dependent and irreversible human COX-2inhibitor with an of 85 nM in an enzymeIC50
assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Timegadine (SR1368) Cat No HY-100125
Timegadine a new antiinflammatory agent is foundto be a potent competitive inhibitor of
( ) and withcyclo-oxygenase COX lipo-oxygenases ranging from 5 nM (washed rabbit platelets)IC50
to 20 μM (rat brain) for COX and 100 μM forlipo-oxygenase both in the cytosol fractionhellip
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tolfenamic Acid (GEA 6414) Cat No HY-B0335
Tolfenamic Acid (GEA 6414) is a non-steroidalanti-inflammatory and anti-cancer agentselectively inhibits with an of 1349COX-2 IC50
μM (353 μgmL) in LPS-treated (COX-2) canine DH82monocytemacrophage cells but shows no effect onCOX-1
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 10 g
Tolmetin sodium dihydrateCat No HY-B1489
Tolmetin sodium dihydrate is a non-steroidalantiinflammatory agent and acts as anon-selective inhibitorCOX
Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
TriflusalCat No HY-B0531
Triflusal irreversibly inhibits the production ofthromboxane-B2 in platelets by acetylatingcycloxygenase-1 Target COX Triflusal at 10 mM100 mM and 1 M decreases LDH efflux in rat brainslices after anoxiareoxygenation by 24 35 and49 respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Valdecoxib (SC 65872) Cat No HY-15762
Valdecoxib is a highly potent and selectiveinhibitor of with s of 5 nM and 140 μMCOX-2 IC50
for COX-2 and COX-1 respeceively Valdecoxib canbe used in the research of arthritis and pain
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Veratric acid (34-Dimethoxybenzoic acid) Cat No HY-N2007
Veratric acid (34-Dimethoxybenzoic acid) is anorally active phenolic compound derived fromvegetables and fruits has antioxidant andanti-inflammatory activities
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
XanthohumolCat No HY-N1067
Xanthohumol is one of the principal flavonoidsisolated from hops the inhibitor ofdiacylglycerol acetyltransferase ( ) DGAT COX-1and COX-2 and shows anti-cancer andanti-angiogenic activities
Purity 9968Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 25 mg
Zaltoprofen (CN100) Cat No HY-B0619
Zaltoprofen(CN100) is an inhibitor of COX fortreatment of arthritis
Purity 9909Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
[10]-ShogaolCat No HY-N2434
[10]-Shogaol is an antioxidant from Zingiber for human skin cell growth and aofficinale
migration enhancer [10]-Shogaol inhibits COX-2with an of 75 μM and has antiproliferationIC50
activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
16 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
[8]-ShogaolCat No HY-N2435
-Shogaol one of the pungent phenolic compounds inginger exhibits anti-platelet activity ( =5IC50
μM) and inhibits COX-2 ( =175 μM) -ShogaolIC50
induces apoptosis in human leukemia cells
Purity 9918Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-Humulene (Humulene α-Caryophyllene) Cat No HY-N6968
α-Humulene is a main constituent of Tanacetum L (Asteraceae) essential oil withvulgare
anti-inflammation (IC =15plusmn2 microgmL) α-Humulene50
inhibits and expressionCOX-2 iNOS
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-ChaconineCat No HY-129113
α-Chaconine isolated from a Solanum L cv Jayoung inhibits thetuberosum
expressions of and atCOX-2 IL-1β IL-6 TNF-αthe transcriptional level
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 17
SC-560Cat No HY-59105
SC-560 is a potent and selective inhibitorCOX-1with an of 9 nMIC50
Purity 9958Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SC57666Cat No HY-U00129
SC57666 is a selective inhibitor with anCOX2 of 26 nMIC50
Purity 9894Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 20 mg
SC58451Cat No HY-U00239
SC58451 is a potent and selective Cox-2inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Sodium Salicylate (Salicylic acid sodium salt
2-Hydroxybenzoic acid sodium salt) Cat No HY-B0167A
Sodium Salicylate inhibits cyclo-oxygenase-2( ) activity independently of transcriptionCOX-2factor (NF-κB) activation
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g
Sulindac (MK-231) Cat No HY-B0008
Sulindac (MK-231) is a non-steroidalantiinflammatory agent acts as a COX-2inhibitor and inhibits overexpression of COX-2
Purity 9978Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
SyringaldehydeCat No HY-N1390
Syringaldehyde is a polyphenolic compoundbelonging to the group of flavonoids and is foundin different plant species like Manihot
and esculenta Magnolia officinalisSyringaldehyde moderately inhibits activityCOX-2with an of 35 μgmLIC50
Purity 9996Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
Tenidap (CP-66248) Cat No HY-105028
Tenidap a non-steroidal anti-inflammatory drugis a selective inhibitor with valuesCOX-1 IC50
of 003 microM and 12 microM for COX-1 and COX-2respectively Tenidap has anti-inflammatory andantirheumatic properties Tenidap is also aspecific SLC26A3 inhibitor
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tenoxicam (Ro-12-0068) Cat No HY-B0440
Tenoxicam (Ro-12-0068) an antiinflammatory agentwith analgesic and antipyretic properties
Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) Cat No HY-112731
TFAP is a selective cyclooxygenase-1 (COX-1)inhibitor with an of 08 μMIC50
Purity 9997Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Thioflosulide (L-745337) Cat No HY-19217
Thioflosulide (L-745337) is a selective inhibitor with an ofcyclooxygenase-2 (COX2) IC50
23 nM and shows anti-inflammatory activity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg
wwwMedChemExpresscom 15
Tilmacoxib (JTE522 JTP19605 RWJ57504) Cat No HY-U00197
Tilmacoxib (JTE522) is a highly selectivetime-dependent and irreversible human COX-2inhibitor with an of 85 nM in an enzymeIC50
assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Timegadine (SR1368) Cat No HY-100125
Timegadine a new antiinflammatory agent is foundto be a potent competitive inhibitor of
( ) and withcyclo-oxygenase COX lipo-oxygenases ranging from 5 nM (washed rabbit platelets)IC50
to 20 μM (rat brain) for COX and 100 μM forlipo-oxygenase both in the cytosol fractionhellip
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tolfenamic Acid (GEA 6414) Cat No HY-B0335
Tolfenamic Acid (GEA 6414) is a non-steroidalanti-inflammatory and anti-cancer agentselectively inhibits with an of 1349COX-2 IC50
μM (353 μgmL) in LPS-treated (COX-2) canine DH82monocytemacrophage cells but shows no effect onCOX-1
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 10 g
Tolmetin sodium dihydrateCat No HY-B1489
Tolmetin sodium dihydrate is a non-steroidalantiinflammatory agent and acts as anon-selective inhibitorCOX
Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
TriflusalCat No HY-B0531
Triflusal irreversibly inhibits the production ofthromboxane-B2 in platelets by acetylatingcycloxygenase-1 Target COX Triflusal at 10 mM100 mM and 1 M decreases LDH efflux in rat brainslices after anoxiareoxygenation by 24 35 and49 respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Valdecoxib (SC 65872) Cat No HY-15762
Valdecoxib is a highly potent and selectiveinhibitor of with s of 5 nM and 140 μMCOX-2 IC50
for COX-2 and COX-1 respeceively Valdecoxib canbe used in the research of arthritis and pain
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Veratric acid (34-Dimethoxybenzoic acid) Cat No HY-N2007
Veratric acid (34-Dimethoxybenzoic acid) is anorally active phenolic compound derived fromvegetables and fruits has antioxidant andanti-inflammatory activities
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
XanthohumolCat No HY-N1067
Xanthohumol is one of the principal flavonoidsisolated from hops the inhibitor ofdiacylglycerol acetyltransferase ( ) DGAT COX-1and COX-2 and shows anti-cancer andanti-angiogenic activities
Purity 9968Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 25 mg
Zaltoprofen (CN100) Cat No HY-B0619
Zaltoprofen(CN100) is an inhibitor of COX fortreatment of arthritis
Purity 9909Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
[10]-ShogaolCat No HY-N2434
[10]-Shogaol is an antioxidant from Zingiber for human skin cell growth and aofficinale
migration enhancer [10]-Shogaol inhibits COX-2with an of 75 μM and has antiproliferationIC50
activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
16 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
[8]-ShogaolCat No HY-N2435
-Shogaol one of the pungent phenolic compounds inginger exhibits anti-platelet activity ( =5IC50
μM) and inhibits COX-2 ( =175 μM) -ShogaolIC50
induces apoptosis in human leukemia cells
Purity 9918Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-Humulene (Humulene α-Caryophyllene) Cat No HY-N6968
α-Humulene is a main constituent of Tanacetum L (Asteraceae) essential oil withvulgare
anti-inflammation (IC =15plusmn2 microgmL) α-Humulene50
inhibits and expressionCOX-2 iNOS
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-ChaconineCat No HY-129113
α-Chaconine isolated from a Solanum L cv Jayoung inhibits thetuberosum
expressions of and atCOX-2 IL-1β IL-6 TNF-αthe transcriptional level
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 17
Tilmacoxib (JTE522 JTP19605 RWJ57504) Cat No HY-U00197
Tilmacoxib (JTE522) is a highly selectivetime-dependent and irreversible human COX-2inhibitor with an of 85 nM in an enzymeIC50
assay
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg
Timegadine (SR1368) Cat No HY-100125
Timegadine a new antiinflammatory agent is foundto be a potent competitive inhibitor of
( ) and withcyclo-oxygenase COX lipo-oxygenases ranging from 5 nM (washed rabbit platelets)IC50
to 20 μM (rat brain) for COX and 100 μM forlipo-oxygenase both in the cytosol fractionhellip
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Tolfenamic Acid (GEA 6414) Cat No HY-B0335
Tolfenamic Acid (GEA 6414) is a non-steroidalanti-inflammatory and anti-cancer agentselectively inhibits with an of 1349COX-2 IC50
μM (353 μgmL) in LPS-treated (COX-2) canine DH82monocytemacrophage cells but shows no effect onCOX-1
Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 10 g
Tolmetin sodium dihydrateCat No HY-B1489
Tolmetin sodium dihydrate is a non-steroidalantiinflammatory agent and acts as anon-selective inhibitorCOX
Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
TriflusalCat No HY-B0531
Triflusal irreversibly inhibits the production ofthromboxane-B2 in platelets by acetylatingcycloxygenase-1 Target COX Triflusal at 10 mM100 mM and 1 M decreases LDH efflux in rat brainslices after anoxiareoxygenation by 24 35 and49 respectively
Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Valdecoxib (SC 65872) Cat No HY-15762
Valdecoxib is a highly potent and selectiveinhibitor of with s of 5 nM and 140 μMCOX-2 IC50
for COX-2 and COX-1 respeceively Valdecoxib canbe used in the research of arthritis and pain
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
Veratric acid (34-Dimethoxybenzoic acid) Cat No HY-N2007
Veratric acid (34-Dimethoxybenzoic acid) is anorally active phenolic compound derived fromvegetables and fruits has antioxidant andanti-inflammatory activities
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
XanthohumolCat No HY-N1067
Xanthohumol is one of the principal flavonoidsisolated from hops the inhibitor ofdiacylglycerol acetyltransferase ( ) DGAT COX-1and COX-2 and shows anti-cancer andanti-angiogenic activities
Purity 9968Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 25 mg
Zaltoprofen (CN100) Cat No HY-B0619
Zaltoprofen(CN100) is an inhibitor of COX fortreatment of arthritis
Purity 9909Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
[10]-ShogaolCat No HY-N2434
[10]-Shogaol is an antioxidant from Zingiber for human skin cell growth and aofficinale
migration enhancer [10]-Shogaol inhibits COX-2with an of 75 μM and has antiproliferationIC50
activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg
16 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
[8]-ShogaolCat No HY-N2435
-Shogaol one of the pungent phenolic compounds inginger exhibits anti-platelet activity ( =5IC50
μM) and inhibits COX-2 ( =175 μM) -ShogaolIC50
induces apoptosis in human leukemia cells
Purity 9918Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-Humulene (Humulene α-Caryophyllene) Cat No HY-N6968
α-Humulene is a main constituent of Tanacetum L (Asteraceae) essential oil withvulgare
anti-inflammation (IC =15plusmn2 microgmL) α-Humulene50
inhibits and expressionCOX-2 iNOS
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-ChaconineCat No HY-129113
α-Chaconine isolated from a Solanum L cv Jayoung inhibits thetuberosum
expressions of and atCOX-2 IL-1β IL-6 TNF-αthe transcriptional level
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 17
[8]-ShogaolCat No HY-N2435
-Shogaol one of the pungent phenolic compounds inginger exhibits anti-platelet activity ( =5IC50
μM) and inhibits COX-2 ( =175 μM) -ShogaolIC50
induces apoptosis in human leukemia cells
Purity 9918Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-Humulene (Humulene α-Caryophyllene) Cat No HY-N6968
α-Humulene is a main constituent of Tanacetum L (Asteraceae) essential oil withvulgare
anti-inflammation (IC =15plusmn2 microgmL) α-Humulene50
inhibits and expressionCOX-2 iNOS
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
α-ChaconineCat No HY-129113
α-Chaconine isolated from a Solanum L cv Jayoung inhibits thetuberosum
expressions of and atCOX-2 IL-1β IL-6 TNF-αthe transcriptional level
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 17
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