cox · cox cyclooxygenase cyclooxygenase (cox), officially known as prostaglandin-endoperoxide...

COXCyclooxygenase

Cyclooxygenase (COX) officially known as prostaglandin-endoperoxide synthase (PTGS) is an enzyme that is responsible forformation of important biological mediators called prostanoids including prostaglandins prostacyclin and thromboxanePharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain Drugs like Aspirin that inhibitcyclooxygenase activity have been available to the public for about 100 years Two cyclooxygenase isoforms have been identifiedand are referred to as COX-1 and COX-2 Under many circumstances the COX-1 enzyme is produced constitutively (ie gastricmucosa) whereas COX-2 is inducible (ie sites of inflammation) Non-steroidal anti-inflammatory drugs (NSAID) such as aspirin andibuprofen exert their effects through inhibition of COX The main COX inhibitors are the non-steroidal anti-inflammatory drugs(NSAIDs)

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COX Inhibitors Antagonists amp Activators

(+)-Catechin hydrateCat No HY-N0355

(+)-Catechin hydrate inhibits cyclooxygenase-1( ) with an of 14 μMCOX-1 IC50

Purity 9922Clinical Data Phase 4Size 100 mg

(-)-Catechin ((-)-Cianidanol (-)-Catechuic acid) Cat No HY-N0898A

(-)-Catechin isolated from green tea is anisomer of Catechin having a trans 2S3Rconfiguration at the chiral center Catechininhibits cyclooxygenase-1 (COX-1) with an IC of50

14 μM

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

(-)-Catechin gallate ((-)-Catechin 3-gallate (-)-Catechin 3-O-gallate) Cat No HY-N0356

(-)-Catechin gallate is a minor constituent ingreen tea catechins (-)-Catechin gallate inhibitsthe activity of and enzymesCOX-1 COX-2

Purity 9998Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg

(-)-Epicatechin ((-)-Epicatechol Epicatechin epi-Catechin) Cat No HY-N0001

(-)-Epicatechin inhibits cyclooxygenase-1 ( )COX-1with an of 32 μM (-)-Epicatechin inhibitsIC50

the IL-1β-induced expression of iNOS by blockingthe nuclear localization of the p65 subunit ofNF-κB

Purity 9900Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg 100 mg

(-)-Epicatechin gallate (Epicatechin gallate ECG (-)-Epicatechin 3-O-gallate) Cat No HY-N0002

(-)-Epicatechin gallate (Epicatechin gallate)inhibits cyclooxygenase-1 ( ) with an ofCOX-1 IC50

75 μM

Purity 9857Clinical Data Phase 4Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg

(E)-Ethyl p-methoxycinnamateCat No HY-N0346A

(E)-Ethyl p-methoxycinnamate is a natural productfound in withKaempferia galangalanti-inflammatory anti-neoplastic andanti-microbial effects

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg

(S)-(+)-Ibuprofen ((S)-Ibuprofen) Cat No HY-78131A

(S)-(+)-Ibuprofen is the S(+)-enantiomer ofIbuprofen that inhibits and activityCOX-1 COX-2with s of 21 μM and 16 μM (S)-(+)-IbuprofenIC50

has analgesic antiinflammatory and antipyreticeffects

Purity 9999Clinical Data No Development ReportedSize 500 mg 1 g 5 g

(S)-(+)-Ibuprofen D3 ((S)-Ibuprofen D3) Cat No HY-78131AS

(S)-(+)-Ibuprofen D3 ((S)-Ibuprofen D3) is adeuterium labeled (S)-(+)-Ibuprofen(S)-(+)-Ibuprofen is the S(+)-enantiomer ofIbuprofen that inhibits and activityCOX-1 COX-2with s of 21 μM and 16 μMIC50


(S)-Ketorolac ((-)-Ketorolac) Cat No HY-B0580A

(S)-Ketorolac is a nonsteroidal anti-inflammatoryagent (S)-ketorolac exhibits potent andCOX1

enzyme inhibitionCOX2

Purity 9887Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg

2-Hydroxy Ibuprofen ((plusmn)-2-Hydroxy Ibuprofen) Cat No HY-126121

2-Hydroxy Ibuprofen is a metabolite of IbuprofenIbuprofen is an anti-inflammatory inhibitortargeting COX-1 and COX-2 with IC s of 13 μM and50

370 μM respectively


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20(S)-Ginsenoside Rg3 (20(S)-Propanaxadiol S-ginsenoside Rg3) Cat No HY-N0603

20(S)-Ginsenoside Rg3 is the main component of Redginseng Ginsenoside Rg3 inhibits andNa+

channel with IC s of 322plusmn45 and 326plusmn22hKv14 50

μM respectively 20(S)-Ginsenoside Rg3 alsoinhibits levels activity and Aβ NF-κB COX-2expression

Purity gt980Clinical Data Phase 2Size 10 mM times 1 mL 10 mg 50 mg 100 mg

AceclofenacCat No HY-B0634

Aceclofenac is a non-steroidal anti-inflammatorydrug (NSAID) analog of Diclofenac Target COXAceclofenac is a non-steroidal anti-inflammatorydrug (NSAID) analog of Diclofenac

Purity 9980Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g

Acemetacin (TVX 1322) Cat No HY-B0482

Acemetacin (TVX 1322) is a non-steroidalanti-inflammatory drug and a glycolic acid esterof indometacin that is a cyclooxygenase inhibitor


Acetaminophen (Paracetamol 4-Hydroxyacetanilide

4-Acetamidophenol APAP) Cat No HY-66005

Acetaminophen (paracetamol) is a selectivecyclooxygenase-2 ( ) inhibitor with an COX-2 IC50

of 258 μM is a widely used antipyretic andanalgesic drug Acetaminophen is a potent hepatic

inhibitorN-acetyltransferase 2 (NAT2)

Purity 9969Clinical Data LaunchedSize 500 mg 5 g 10 g

AdelmidrolCat No HY-B1026

Adelmidrol exerts important anti-inflammatoryeffects that are partly dependent on PPARγAdelmidrol reduces translocation andNF-κB

expressionCOX-2

Purity gt980Clinical Data Phase 3Size 10 mM times 1 mL 100 mg

Amfenac Sodium HydrateCat No HY-17479A

Amfenac Sodium Hydrate is a inhibitorCOX-2


Ampiroxicam (CP 65703) Cat No HY-17484

Ampiroxicam(CP65703) is a nonselectivecyclooxygenase inhibitor uesd as anti-inflammatorydrug Target COX Ampiroxicam is a non-steroidalanti-inflammatory drug It is a prodrug ofpiroxicam

Purity 9712Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg

Ampyrone (4-Aminoantipyrine) Cat No HY-B1398

Ampyrone is a reagent for glucose determination inthe presence of peroxidase and phenol

Purity 9886Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g

Anemarsaponin BCat No HY-N0811

Anemarsaponin B is a steroidal saponin isolatedfrom the rhizomes of (Liliaceae)A asphodeloidesAnemarsaponin B decreases the protein and mRNAlevels of and iNOS COX-2


Asaraldehyde (Asaronaldehyde Asaraldehyde

245-trimethoxy-Benzaldehyde) Cat No HY-100580

Asarylaldehyde is a natural inhibitorCOX-2which isolated from carrot ( L) seedsDaucus carotasignificantly inhibits cyclooxygenase II (COX-2)activity at value 100 μgmLIC50

Purity 9968Clinical Data No Development ReportedSize 100 mg


Aspirin (Acetylsalicylic Acid ASA) Cat No HY-14654

Aspirin is a non-selective and irreversibleinhibitor of and with s of 5 andCOX-1 COX-2 IC50

210 μgmL


ATB-346Cat No HY-15028

ATB-346 is a novel hydrogen sulphide-releasingderivative of naproxen with markedly reducedtoxicity


Benzoylgomisin OCat No HY-N2266

Benzoylgomisin O isolated from Schisandra has inhibitory activity againstrubriflora

and enzymes and15-LOX COX-1 COX-2anti-inflammatory activity


ByakangelicolCat No HY-N0074

Byakangelicol isolated from Angelica dahuricainhibits interleukin-1beta (IL-1beta) -inducedprostaglandin E2 (PGE2) release in A549 cellsmediated by suppression of cyclooxygenase-2

expression and the activity of COX-2(COX-2)enzyme


CafestolCat No HY-N6257

Cafestol one of the major components of coffeeis a coffee-specific diterpene from Cafestol is a

inhibitor for AP-1-targeted activity againstERK production and the mRNA expression ofPGE2

in LPS-activated RAW2647cyclooxygenase (COX)-2cells


CarprofenCat No HY-B1227

Carprofen is a nonsteroid anti-inflammatory agentacts as a multi-target inhibitor withFAAHCOX

s of 39 μM 223 μM and 786 μM for COX-2IC50

COX-1 and FAAH respectively

Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 100 mg

Catechin ((+)-Catechin Cianidanol Catechuic acid) Cat No HY-N0898

Catechin inhibits cyclooxygenase-1 ( ) withCOX-1an of 14 μMIC50


Celecoxib (SC 58635) Cat No HY-14398

Celecoxib is a selective inhibitor with anCOX-2 of 40 nMIC50

Purity 9950Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 1 g

ColumbinCat No HY-N0389

Columbin is a diterpenoid furanolactone withanti-inflammation activity

Purity 9886Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg

COX-2-IN-1Cat No HY-U00275

COX-2-IN-1 is potent and slective inhibitorCOX-2with an of 39 μMIC50

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg


COX-2-IN-2Cat No HY-101655

COX-2-IN-2 is a selective and inducible COX2inhibitor with an of 024 μM COX-2-IN-1 isIC50

an anti-inflammatory compound withanti-inflammatory and analgesic activities


COX5-LO-IN-1 (Atreleuton analog) Cat No HY-U00347

COX5-LO-IN-1 (Atreleuton analog) is an inhibitorof and usedcylooxygenase 5-lipoxygenase (5-LO)for the research of inflammatory and allergicdisease states


Crocin IICat No HY-N0698

Crocin II is isolated from the fruit of Gardenia with antioxidant anticancer andjasminoides

antidepressant activity Crocin II inhibits NOproduction with an value of 311 μM CrocinIC50

II suppresses the expressions of protein and m-RNAof and iNOS COX-2


DehydrodiisoeugenolCat No HY-N0589

Dehydrodiisoeugenol is isolated from Myristica shows anti-inflammatory andfragrans Houtt

anti-bacterial actions Dehydrodiisoeugenolinhibits LPS- stimulated activation andNF-κBcyclooxygenase ( )-2 gene expression in murineCOXmacrophages


DehydroevodiamineCat No HY-N2106

Dehydroevodiamine is a major bioactive quinazolinealkaloid isolated from has anEvodiae Fructusantiarrhythmic effect in guinea-pig ventricularmyocytes


Deracoxib (SC 046 SC 46 SC 59046) Cat No HY-17509

Deracoxib a selective cyclooxygenase-2 inhibitoris a non-narcotic non-steroidal anti-inflammatorydrug (NSAID)


Desmethyl CelecoxibCat No HY-118139

Desmethyl Celecoxib (compound 3b) is a selectivecyclooxygenase-2 ( ) inhibitor ( =32 nM)COX-2 IC50

with anti-inflammatory activities DesmethylCelecoxib is an analog of Celecoxib andwith the optimal yield of 75


DiclofenacCat No HY-15036

Diclofenac is a potent and nonselectiveanti-inflammatory agent acts as a inhibitorCOXwith s of 4 nM 13 nM for human COX-1 andIC50

COX-2 in CHO cells and 51 084 μM for ovineCOX-1 and COX-2 respectively


Diclofenac diethylamineCat No HY-15036A

Diclofenac diethylamine is a potent andnonselective anti-inflammatory agent acts as a

inhibitor with s of 4 nM 13 nM forCOX IC50

human COX-1 and COX-2 in CHO cells and 51 084μM for ovine COX-1 and COX-2 respectively


Diclofenac Sodium (GP 45840) Cat No HY-15037

Diclofenac Sodium (GP 45840) is a potent andnonselective anti-inflammatory agent acts as a





Diflunisal (MK-647) Cat No HY-18342

Diflunisal (MK-647) is a salicylate derivativewith nonsteroidal anti-inflammatory and uricosuricproperties which is used alone as an analgesicand in rheumatoid arthritis patients Themechanism of action of diflunisal is as aCyclooxygenase ( ) InhibitorCOX


Eicosatetraynoic acid (ETYA) Cat No HY-124108

Eicosatetraynoic acid (ETYA) is a nonspecificinhibitor of and ( =8cyclooxygenase lipoxygenase ID50

μM and 4 μM respectively) Eicosatetraynoic acid(ETYA) activates PPARα and PPARγ chimeras at 10microM

Purity gt98Clinical DataSize 1 mg

Esculentoside ACat No HY-N0632

Esculentoside A (EsA) a kind of triterpenesaponin isolated from roots of Phytolacca esculentaEsculentoside A (EsA) possesses anti-inflammatoryactivity in acute and chronic experimental modelshas selective inhibitory activity towardscyclooxygenase-2 ( )COX-2


Ethyl CaffeateCat No HY-N6966

Ethyl Caffeate is a natural phenolic compoundisolated from Bidens pilosa


Etodolac (AY-24236) Cat No HY-76251

Etodolac (AY-24236) is a non-steroidalanti-inflammatory compound that is a non-selectiveinhibitor of COX (IC =535 nM)50


Etoricoxib (MK-0663 L-791456) Cat No HY-15321

Etoricoxib (MK-0663) is a non steroidalanti-inflammatory agent acting as a selective andorally active inhibitor with s of 11COX-2 IC50

μM and 116 μM for COX-2 and COX-1 in human wholeblood

Purity 9992Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg

Etoricoxib D4 (MK-0663 D4 L-791456 D4) Cat No HY-15321S

Etoricoxib D4 (MK-0663 D4) is a deuterium labeledEtoricoxib Etoricoxib is a non steroidalanti-inflammatory agent acting as a selective andorally active inhibitor with s of 11COX-2 IC50



Fenofibric acid (FNF acid) Cat No HY-B0760

Fenofibric acid an active metabolite offenofibrate is a activitor with s ofPPAR EC50

224 microM 147 microM and 106 microM for PPARα PPARγ andPPARδ respectively Fenofibric acid also inhibits

enzyme activity with an of 48 nMCOX-2 IC50


Fenoprofen CalciumCat No HY-B0288A

Fenoprofen Calcium is a nonsteroidalanti-inflammatory antiarthritic agent

Purity gt98Clinical Data LaunchedSize 500 mg 1 g 5 g

Fenoprofen Calcium hydrate (Fenoprofen calcium salt dihydrate) Cat No HY-B0288B

Fenoprofen Calcium hydrate is a nonsteroidalanti-inflammatory antiarthritic agent



Firocoxib (ML 1785713) Cat No HY-14670

Firocoxib(ML 1785713) is a potent and selectivecyclooxygenase (COX)-2 inhibitor with IC50 of 013uM 58 fold sensitivity for COX2 VSCOX1


FK 3311 (COX-2 Inhibitor V) Cat No HY-14445

FK 3311 (COX-2 Inhibitor V) is a selectiveinhibitor of with antiinflammatory agentCOX-2


Flosulide (ZK 38997 CGP 28238) Cat No HY-U00083

Flosulide is a potent and selective COX-2inhibitor used for the treatment for inflammatorydiseases


Flufenamic acidCat No HY-B1221

Flufenamic acid is a non-steroidalanti-inflammatory agent inhibits cyclooxygenase( ) activates and also modulates ionCOX AMPKchannels blocking and chloride channels L-type

modulating non-selective cationCa channels2+

channels ( ) activating NSC K channels+


Flunixin meglumineCat No HY-B0386

Flunixin Meglumine is a potent inhibitor of COXused as analgesic agent with anti-inflammatory andantipyretic activity Target COX Flunixinmeglumine is a potent non-narcotic non-steroidalanalgesic agent with anti-inflammatory andantipyretic activity

Purity 9965Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g

FR-188582Cat No HY-U00146

FR-188582 is a highly selective inhibitor of ( )-2 with an value of 17cyclooxygenase COX IC50

nM

Purity 9921Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Gallic acid (345-Trihydroxybenzoic acid) Cat No HY-N0523

Gallic acid is an antioxidant which can inhibitboth COX-2


Ginsenoside C-K (Ginsenoside compound K Ginsenoside K) Cat No HY-N0904

Ginsenoside C-K a bacterial metabolite of G-Rb1exhibits anti-inflammatory effects by reducing iNOSand Ginsenoside C-K exhibits an inhibitionCOX-2against the activity of and inCYP2C9 CYP2A6human liver microsomes with s of 320plusmn36 μMIC50

and 636plusmn42 μM respectively

Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg

Ginsenoside Rb3 (Gypenoside IV) Cat No HY-N0041

Ginsenoside Rb3 is extracted from steamed Panax Ginsenoside Rb3 exhibits inhibitorynotoginseng

effect on TNFα-induced transcriptionalNF-κBactivity with an of 82 μM in 293T cellIC50

lines Ginsenoside Rb3 also inhibits the inductionof and mRNACOX-2 iNOS


Ginsenoside Rd (Gypenoside VIII) Cat No HY-N0043

Ginsenoside Rd inhibits TNFα-induced NF-κBtranscriptional activity with an ofIC50

1205plusmn082 μM in HepG2 cells Ginsenoside Rdinhibits expression of and mRNACOX-2 iNOSGinsenoside Rd also inhibits influxCa2+



Ginsenoside Rg5Cat No HY-N0908

Ginsenoside Rg5 is the main component of Redginseng Ginsenoside blocks binding of to itsIGF-1receptor with an of ~90 nM Ginsenoside Rg5IC50

also inhibits the mRNA expression of viaCOX-2suppression of the DNA binding activities of

NF-κB p65


GnetolCat No HY-126052

Gnetol is a phenolic compound isolated from theroot of Brongn Gnetol potentlyGnetum ulainhibits ( of 078 μM) and COX-1 IC50 HDACGnetol is a potent inhibitor with antyrosinase

of 45 μM for murine tyrosinase andIC50

suppresses melanin biosynthesis


Guaiacol (2-Methoxyphenol) Cat No HY-N1380

Guaiacol a phenolic compound isolated from Guaiacresin inhibits LPS-stimulated expressionCOX-2and activation Anti-inflammatory activityNF-κB


GW-406381Cat No HY-119304

GW406381 a highly selective cyclooxygenase-2 inhibitor attenuates spontaneous ectopic(COX-2)

discharge in sural nerves of rats followingchronic constriction injury

Purity 9959Clinical DataSize 10 mM times 1 mL 1 mg

HamaudolCat No HY-N6891

Hamaudol is a chromone isolated from Saposhnikovia Hamaudol shows significant inhibitorydivaricata

activity on and cyclooxygenase (COX)-1 COX-2activities with values of 030 057 mMIC50

respectively and has potent analgesia andanti-inflammary effects


HarpagosideCat No HY-N0396

Harpagoside is isolated from Harpagophytum Harpagoside has inhibitory effectsprocumbens (Hp)

on and activity and inhibits NOCOX-1 COX-2production


HexahydrocurcuminCat No HY-N0929

Hexahydrocurcumin is a natural compound whichposesses anticancer and anti-inflammatoryactivities selective COX-2 inhibitor

Purity 9858Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg

Ibuprofen ((plusmn)-Ibuprofen) Cat No HY-78131

Ibuprofen is an anti-inflammatory inhibitortargeting and with s of 13 μMCOX-1 COX-2 IC50

and 370 μM respectively


Ibuprofen D3 ((plusmn)-Ibuprofen D3) Cat No HY-78131S

Ibuprofen D3 is a deuterium labeled IbuprofenIbuprofen is a COX-1 and COX-2 inhibitor with IC s50

of 13 μM and 370 μM


Iguratimod (T614) Cat No HY-17009

Iguratimod is an antirheumatic agent acts as aninhibitor of with an of 20 μM (77COX-2 IC50

μgmL) but shows no effect on COX-1 Iguratimodalso inhibits macrophage migration inhibitoryfactor ( ) with an of 681 μMMIF IC50



Imrecoxib (BAP-909) Cat No HY-114200

Imrecoxib (BAP-909) is a novel and selectivecyclooxygenase 2 ( ) inhibitor with an COX-2 IC50

value of 18 nM it also inhibits COX1- activitywith an value of 115 nM Imrecoxib (BAP-909)IC50

has anti-inflammatory effect


Indobufen (Ibustrin) Cat No HY-18763

Indobufen is a platelet aggregation inhibitorIndobufen is a reversible platelet cyclooxygenase( ) activity inhibitor Indobufen suppressesCoxthromboxane A (TxA ) synthesis Indobufen2 2

down-regulates tissue factor (TF) in monocytes

Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg

Indomethacin (Indometacin) Cat No HY-14397

Indomethacin is a potent and nonselectiveinhibitor of and with s of 18 nMCOX1 COX2 IC50

and 26 nM for human COX-1 and COX-2 respectivelyin CHO cells


Inulicin (1-O-Acetylbritannilactone) Cat No HY-N0896

Inulicin (1-O-Acetylbritannilactone) is an activecompound isolated from InulicinInula Britannica L(1-O-Acetylbritannilactone) inhibits VEGF-mediatedactivation of and Src FAK


Isoorientin (Homoorientin) Cat No HY-N0767

Isoorientin is a potent inhibitor of withCOX-2an value of 39 μMIC50

Purity 9924Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 25 mg 50 mg

JaceosidinCat No HY-N0831

Jaceosidin is a flavonoid isolated from induces apoptosis in cancerArtemisia vestita

cells activates and down-regulates Mcl-1 andBaxc-FLIP expression


Ketoprofen (RP-19583) Cat No HY-B0227

Ketoprofen (RP-19583) is a non-steroidalantiinflammatory agent acting as a potentinhibitor of with s of 2 nM and 26 nMCOX IC50

for COX-1 and COX-2 in human blood monocytesrespectively


Ketorolac (RS37619) Cat No HY-B0580

Ketorolac is a non-steroidal anti-inflammatoryagent acting as a nonselective inhibitorCOXwith s of 20 nM for COX-1 and 120 nM forIC50

COX-2

Purity gt98Clinical Data LaunchedSize 100 mg 500 mg

Ketorolac D5Cat No HY-B0580S

Ketorolac D5 is a deuterium labeled KetorolacKetorolac is a non-steroidal anti-inflammatoryagent acting as a nonselective inhibitorCOXwith s of 20 nM for COX-1 and 120 nM forIC50

COX-2


Ketorolac tromethamine salt (Ketorolac Tromethamine

Ketorolac tris salt RS37619 tromethamine salt) Cat No HY-B0138

Ketorolac tromethamine salt (RS37619 tromethaminesalt) is a non-steroidal anti-inflammatory agentacting as a nonselective inhibitor withCOX

s of 20 nM for COX-1 and 120 nM for COX-2IC50



Licofelone (ML-3000) Cat No HY-B1452

Licofelone (ML-3000) is a dual COX5-lipoxygenase inhibitor ( =021018 μM(5-LOX) IC50

respectively) for the treatment of osteoarthritisLicofelone exerts anti-inflammatory andanti-proliferative effects


Lornoxicam (Chlortenoxicam Ro 13-9297 TS110) Cat No HY-B0367

Lornoxicam a COX-1 and COX-2 inhibitor is a newnonsteroidal anti-inflammatory drug (NSAID)Target COX Lornoxicam showed a balancedinhibition of COX-1-2 exhibiting the lowest IC50(0005 microM0008 microM) of the large panel ofNSAIDs tested


LoxoprofenCat No HY-B0578

Loxoprofen is a non-steroidal anti-inflammatorydrug Target COX Loxoprofen is a non-steroidalanti-inflammatory drug in the propionic acidderivatives group which also includes ibuprofenand naproxen among others

Purity 9882Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg

LY 178002Cat No HY-101579

LY 178002 is a potent inhibitor of 5-lipoxygenase with of 06 μM(5-LPO) phospholipase A2 IC50

for 5-lipoxygenase inhibits cellular productionof LTB4 by human polymorphonuclear leukocytes andshows relatively weak inhibition on cyclooxygenase


MavacoxibCat No HY-119447

Mavacoxib is a selective oral long-acting inhibitor and acyclooxygenase-2 (COX-2)

long-acting non-steroidal anti-inflammatory drug(NSAID) Mavacoxib is used to treat pain andinflammation associated with degenerative jointdisease in dogs


Mefenamic acidCat No HY-B0574

Mefenamic acid is a non-steroidalanti-inflammatory agent acting as a competitiveinhibitor of and with s of 40hCOX-1 hCOX-2 IC50

nM and 3 μM for hCOX-1 and hCOX-2 respectively


MeloxicamCat No HY-B0261

Meloxicam is a non-steroidal antiinflammatoryagent inhibits activity with s of 049COX IC50

microM and 366 microM for COX-2 and COX-1 respectively


Meloxicam D4Cat No HY-B0261S

Meloxicam D4 is deuterium labeled MeloxicamMeloxicam is a non-steroidal antiinflammatoryagent inhibits COX activity with IC s of 049 microM50

and 366 microM for COX-2 and COX-1 respectively


Metamizole sodium hydrateCat No HY-B1279

Metamizole sodium hydrate is a potent analgesicdrug that has been demonstrated to inhibitcyclooxygenase (COX)

Purity gt980Clinical Data LaunchedSize 500 mg

Methyl Salicylate (Wintergreen oil) Cat No HY-Y0189

Methyl Salicylate (Wintergreen oil) is a topicalanalgesic and anti-inflammatory agent Also usedas a pesticide a denaturant a fragranceingredient and a flavoring agent in food andtobacco products A systemic acquired resistance(SAR) signal in tobacco



N-trans-Feruloyltyramine (N-feruloyltyramine Moupinamide) Cat No HY-N2410

N-trans-Feruloyltyramine (N-feruloyltyramine) analkaloid from is an inhibitor of Piper nigru COX1and with potential antioxidant propertiesCOX2N-trans-Feruloyltyramine possessesanti-inflammatory activity


Nabumetone (BRL14777) Cat No HY-B0559

Nabumetone is an orally active non-acidicanti-inflammatory agent acts as a potent andselective inhibitor and is the prodrug ofCOX-2the active metabolite 6MNA


Naproxen ((S)-Naproxen) Cat No HY-15030

Naproxen is a and inhibitor withCOX-1 COX-2s of 872 and 515 μM respectively in cellIC50

assay


Naproxen etemesil (LT-NS 001 MX 1094) Cat No HY-19675

Naproxen etemesil is a lipophilic non-acidicinactive prodrug of naproxen that is hydrolysed topharmacologically active Naproxen once absorbedNaproxen is a and inhibitor withCOX-1 COX-2

s of 872 and 515 μM respectively in cellIC50

assay

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg

Naproxen sodiumCat No HY-15030A

Naproxen sodium is a and inhibitorCOX-1 COX-2with s of 872 and 515 μM respectively inIC50

cell assay


Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) Cat No HY-N0722

Neochlorogenic acid is a natural polyphenoliccompound found in dried fruits and other plantsNeochlorogenic acid inhibits the production of

and Neochlorogenic acid suppressesTNF-α IL-1β protein expressioniNOS and COX-2


Nepafenac (AHR 9434 AL 6515) Cat No HY-17357

Nepafenac(AHR 9434 AL 6515 Nevanac) is aselective COX-2 inhibitor is prodrug of AmfenacIC50 value Target COX-2 Nepafenac is a NSAID(nonsteroidal anti inflammatory drug) that isroutinely used in opthamology to control painfollowing cataract surgery


Nepafenac D5 (AHR-9434 D5 AL-6515 D5) Cat No HY-17357S

Nepafenac D5 is the deuterium labeled Nepafenacwhich is a selective COX-2 inhibitor


Nimesulide (R805) Cat No HY-B0363

Nimesulide is a selective inhibitor withCOX-2s of 70 nM-70 μM in a time-dependent mannerIC50

but it shows no effect on COX-1 (IC gt100 μM)50

Nimesulide has potent anti-inflammatory analgesicand antipyretic properties

Purity 9991Clinical Data Phase 4Size 10 mM times 1 mL 100 mg 500 mg

Nimesulide D5Cat No HY-B0363S

Nimesulide D5 is a deuterium labeled NimesulideNimesulide is a selective inhibitor withCOX-2

s of 70 nM-70 μM in a time-dependent mannerIC50





Nitroaspirin (NCX 4016) Cat No HY-123823

Nitroaspirin (NCX 4016) is a nitric oxide (NO)donor and a nitro-derivative of Aspirin whichcombines with Nitroaspirin to inhibitcyclooxygenase

Purity gt98Clinical DataSize 1 mg 5 mg

Nitroflurbiprofen (HCT 1206 NO-flurbiprofen Nitroxybutyl flurbiprofen) Cat No HY-U00013

Nitroflurbiprofen is a ( )cyclooxygenase COXinhibitor with nitric oxide (NO)-donatingproperties modulates the increased intrahepaticvascular tone in portal hypertensive cirrhoticrats


NS-398Cat No HY-13913

NS-398 is a non-steroidal an-inflammatory agentwith analgesic and antipyretic effects andselectively inhibits prostaglandin GH synthase2cyclooxygenase 2 ( ) activity with an COX-2 IC50

of 38 μM and has no effect on COX-1 at 100 μM


Oxaprozin (Oxaprozinum Wy21743) Cat No HY-B0808

Oxaprozin is an inhibitor of both andCOX-1 with s of 22 μM and 36 μM for humanCOX-2 IC50

platelet COX-1 and IL-1-stimulated human synovialcell COX-2 respectively Oxaprozin also inhibitsthe activation of NF-κB


Oxaprozin D4 (Wy-21743 D4) Cat No HY-B0808S

Oxaprozin D4 is the deuterium labeled Oxaprozinwhich is a non-steroidal anti-inflammatory drug(NSAID)


Pamicogrel (KBT3022) Cat No HY-U00175

Pamicogrel (KBT3022) is a ( )cyclooxygenase COXinhibitor


Paradol ([6]-Gingerone [6]-Paradol) Cat No HY-14617

Paradol is a pungent phenolic substance found inginger and other Zingiberaceae plants Paradol isan effective inhibitor of tumor promotion in mouseskin carcinogenesis binds to cyclooxygenase

active site(COX)-2


Parecoxib (SC 69124) Cat No HY-17474

Parecoxib is a potent and selective COX-2inhibitor IC50 value Target COX-2 in vitro Theprodrug Parecoxib as well as its active metaboliteval have a specific affinity to the cannabinoid(CB) receptor measured in CB1-expressing HEK 293cells and rat brain tissue


Parecoxib Sodium (SC 69124A) Cat No HY-17474A

Parecoxib Sodium (SC 69124A) is a potent andselective COX-2 inhibitor


PelubiprofenCat No HY-12383

Pelubiprofen an orally active and non-steroidalanti-inflammatory drug is a member of the2-arylpropionic acid family and has relativelyselective effects on activityCOX-2



Phenacetin (Acetophenetidin) Cat No HY-B0476

Phenacetin is a non-opioid analgesic withoutanti-inflammatory properties inhibits COX-3activity Target COX Phenacetin is apain-relieving and fever-reducing drug Phenacetinwas withdrawn from the Canadian market in June1973 due to concerns regarding nephropathy


PhenylbutazoneCat No HY-B0230

Phenylbutazone is used as a non-steroidalanti-inflammatory agent for the treatment ofchronic pain including the symptoms of arthritisTarget Others Phenylbutazone was originally madeavailable for use in humans for the treatment ofrheumatoid arthritis and gout in 1949


Piroxicam (CP-16171) Cat No HY-B0253

Piroxicam (CP-16171) is a non-steroidalanti-inflammatory drugs acts as a inhibitorCOXwith s of 47 25 μM for human monocyte COX-1IC50

and COX-2 respectively

Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g 10 g

Piroxicam D3 (CP-16171 D3) Cat No HY-B0253S

Piroxicam D3 (CP-16171 D3) is deuterium labeledPiroxicam Piroxicam is a non-steroidalanti-inflammatory drugs acts as a COX inhibitorwith IC s of 47 25 μM for human monocyte COX-150



Prim-O-glucosylcimifuginCat No HY-N0635

Prim-O-glucosylcimifugin exerts anti-inflammatoryeffects through the inhibition of and iNOS COX-2expression by through regulating JAK2STAT3signaling


Propyphenazone (4-Isopropylantipyrine Isopropylphenazone) Cat No HY-A0273

Propyphenazone is a pyrazolone derivative withanti-inflammatory analgesic and antipyreticactivity Propyphenazone-based analogues asprodrugs and selective cyclooxygenase-2inhibitors


PsoralidinCat No HY-N0232

Psoralidin isolated from the seed of Psoralea is a dual inhibitor of andcorylifolia COX-2

regulates ionizing radiation (IR)-induced5-LOXpulmonary inflammationAnti-canceranti-bacterial and anti-inflammatory properties

Purity 9990Clinical Data No Development ReportedSize 5 mg 10 mg

Rebamipide (OPC12759 Proamipide) Cat No HY-B0360

Rebamipide (OPC12759) is a mucoprotective agentRebamipide induces expression increasesCOX-2

levels and enhances gastric mucosal defensePGE2in a COX-2-dependent manner


Rebamipide D4 (OPC12759 D4 Proamipide D4) Cat No HY-B0360S

Rebamipide D4 (OPC12759 D4) is deuterium labeledRebamipide Rebamipide is a mucoprotective agentRebamipide induces expression increasesCOX-2



Revaprazan hydrochlorideCat No HY-N7067

Revaprazan hydrochloride is a novel acid pumpantagonist ( ) Revaprazan hydrochlorideAPAreduces expression and has significantCOX-2anti-inflammatory actions activities in H pyloriinfection



RHC 80267 (U-57908) Cat No HY-107416

RHC 80267 (U-57908) is a potent and selectiveinhibitor of (withdiacylglycerol lipase (DAGL)

of 4 μM in canine platelets) RHC-80267IC50

inhibits activity with an of 4cholinesterase IC50

μM thereby enhancing the relaxation evoked byacetylcholine

Purity gt98Clinical Data No Development ReportedSize 10 mM1m 10 mg 25 mg 50 mg 100 mg

Roburic acidCat No HY-N0481

Roburic acid a tetracyclic triterpenoid found in acts as an inhibitor ofGentiana macrophylla

with s of 5 and 9 μM for COX-1 andCOX IC50

COX-2 respectively


Rofecoxib (MK 966) Cat No HY-17372

Rofecoxib is a potent specific and orally active inhibitor with s of 26 and 18 nM forCOX-2 IC50

human COX-2 in human osteosarcoma cells andChinese hamster ovary cells with a 1000-foldselectivity for COX-2 over human COX-1 (IC gt50

50 μM in U937 cells and gt 15 μM inhellip


Rutaecarpine (Rutecarpine) Cat No HY-N0147

Rutaecarpine an alkaloid of isEvodia rutaecarpaan inhibitor of with an value of 028COX-2 IC50

μM


RWJ 63556Cat No HY-U00022

RWJ 63556 is an orally active COX-2 inhibitor withselective5-lipoxygenase

anti-inflammatory activities


S-(+)-Ketoprofen ((S)-Ketoprofen Dexketoprofen) Cat No HY-B2137

S-(+)-Ketoprofen is a potent inhibitor of both and with s of 19 and 27 nMCOX-1 COX-2 IC50

respectively


S-(+)-Marmesin ((+)-Marmesin (S)-Marmesin) Cat No HY-N2176

S-(+)-Marmesin is a natural coumarin exhibiting dual inhibitory activityCOX-25-LOX

Purity 9904Clinical Data No Development ReportedSize 2 mg 5 mg 10 mg 25 mg 50 mg

S-2474Cat No HY-19212

S-2474 is an inhibitor of and COX-2 5-lipoxygenase with s of 11 nM and 27 μM for COX-2(5-LO) IC50

and COX-1 in human intact cells and used as anonsteroidal anti-inflammatory drug


Salicin (D-(minus)-Salicin Salicoside) Cat No HY-N0149

Salicin is a natural inhibitorCOX


Salicylic acid (2-Hydroxybenzoic acid) Cat No HY-B0167

Salicylic acid inhibits cyclo-oxygenase-2 ( )COX-2activity independently of transcription factor(NF-κB) activation

Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g 50 g


SC-560Cat No HY-59105

SC-560 is a potent and selective inhibitorCOX-1with an of 9 nMIC50


SC57666Cat No HY-U00129

SC57666 is a selective inhibitor with anCOX2 of 26 nMIC50



SC58451 is a potent and selective Cox-2inhibitor


Sodium Salicylate (Salicylic acid sodium salt

2-Hydroxybenzoic acid sodium salt) Cat No HY-B0167A

Sodium Salicylate inhibits cyclo-oxygenase-2( ) activity independently of transcriptionCOX-2factor (NF-κB) activation


Sulindac (MK-231) Cat No HY-B0008

Sulindac (MK-231) is a non-steroidalantiinflammatory agent acts as a COX-2inhibitor and inhibits overexpression of COX-2


SyringaldehydeCat No HY-N1390

Syringaldehyde is a polyphenolic compoundbelonging to the group of flavonoids and is foundin different plant species like Manihot

and esculenta Magnolia officinalisSyringaldehyde moderately inhibits activityCOX-2with an of 35 μgmLIC50


Tenidap (CP-66248) Cat No HY-105028

Tenidap a non-steroidal anti-inflammatory drugis a selective inhibitor with valuesCOX-1 IC50

of 003 microM and 12 microM for COX-1 and COX-2respectively Tenidap has anti-inflammatory andantirheumatic properties Tenidap is also aspecific SLC26A3 inhibitor


Tenoxicam (Ro-12-0068) Cat No HY-B0440

Tenoxicam (Ro-12-0068) an antiinflammatory agentwith analgesic and antipyretic properties


TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) Cat No HY-112731

TFAP is a selective cyclooxygenase-1 (COX-1)inhibitor with an of 08 μMIC50


Thioflosulide (L-745337) Cat No HY-19217

Thioflosulide (L-745337) is a selective inhibitor with an ofcyclooxygenase-2 (COX2) IC50

23 nM and shows anti-inflammatory activity



Tilmacoxib (JTE522 JTP19605 RWJ57504) Cat No HY-U00197

Tilmacoxib (JTE522) is a highly selectivetime-dependent and irreversible human COX-2inhibitor with an of 85 nM in an enzymeIC50

assay


Timegadine (SR1368) Cat No HY-100125

Timegadine a new antiinflammatory agent is foundto be a potent competitive inhibitor of

( ) and withcyclo-oxygenase COX lipo-oxygenases ranging from 5 nM (washed rabbit platelets)IC50

to 20 μM (rat brain) for COX and 100 μM forlipo-oxygenase both in the cytosol fractionhellip


Tolfenamic Acid (GEA 6414) Cat No HY-B0335

Tolfenamic Acid (GEA 6414) is a non-steroidalanti-inflammatory and anti-cancer agentselectively inhibits with an of 1349COX-2 IC50

μM (353 μgmL) in LPS-treated (COX-2) canine DH82monocytemacrophage cells but shows no effect onCOX-1


Tolmetin sodium dihydrateCat No HY-B1489

Tolmetin sodium dihydrate is a non-steroidalantiinflammatory agent and acts as anon-selective inhibitorCOX


TriflusalCat No HY-B0531

Triflusal irreversibly inhibits the production ofthromboxane-B2 in platelets by acetylatingcycloxygenase-1 Target COX Triflusal at 10 mM100 mM and 1 M decreases LDH efflux in rat brainslices after anoxiareoxygenation by 24 35 and49 respectively


Valdecoxib (SC 65872) Cat No HY-15762

Valdecoxib is a highly potent and selectiveinhibitor of with s of 5 nM and 140 μMCOX-2 IC50

for COX-2 and COX-1 respeceively Valdecoxib canbe used in the research of arthritis and pain


Veratric acid (34-Dimethoxybenzoic acid) Cat No HY-N2007

Veratric acid (34-Dimethoxybenzoic acid) is anorally active phenolic compound derived fromvegetables and fruits has antioxidant andanti-inflammatory activities


XanthohumolCat No HY-N1067

Xanthohumol is one of the principal flavonoidsisolated from hops the inhibitor ofdiacylglycerol acetyltransferase ( ) DGAT COX-1and COX-2 and shows anti-cancer andanti-angiogenic activities


Zaltoprofen (CN100) Cat No HY-B0619

Zaltoprofen(CN100) is an inhibitor of COX fortreatment of arthritis


[10]-ShogaolCat No HY-N2434

[10]-Shogaol is an antioxidant from Zingiber for human skin cell growth and aofficinale

migration enhancer [10]-Shogaol inhibits COX-2with an of 75 μM and has antiproliferationIC50

activity




-Shogaol one of the pungent phenolic compounds inginger exhibits anti-platelet activity ( =5IC50

μM) and inhibits COX-2 ( =175 μM) -ShogaolIC50

induces apoptosis in human leukemia cells


α-Humulene (Humulene α-Caryophyllene) Cat No HY-N6968

α-Humulene is a main constituent of Tanacetum L (Asteraceae) essential oil withvulgare

anti-inflammation (IC =15plusmn2 microgmL) α-Humulene50

inhibits and expressionCOX-2 iNOS


α-SpinasterolCat No HY-N6962

α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects


α-ChaconineCat No HY-129113

α-Chaconine isolated from a Solanum L cv Jayoung inhibits thetuberosum

expressions of and atCOX-2 IL-1β IL-6 TNF-αthe transcriptional level



COX Inhibitors Antagonists amp Activators

(+)-Catechin hydrateCat No HY-N0355

(+)-Catechin hydrate inhibits cyclooxygenase-1( ) with an of 14 μMCOX-1 IC50

Purity 9922Clinical Data Phase 4Size 100 mg

(-)-Catechin ((-)-Cianidanol (-)-Catechuic acid) Cat No HY-N0898A

(-)-Catechin isolated from green tea is anisomer of Catechin having a trans 2S3Rconfiguration at the chiral center Catechininhibits cyclooxygenase-1 (COX-1) with an IC of50

14 μM


(-)-Catechin gallate ((-)-Catechin 3-gallate (-)-Catechin 3-O-gallate) Cat No HY-N0356

(-)-Catechin gallate is a minor constituent ingreen tea catechins (-)-Catechin gallate inhibitsthe activity of and enzymesCOX-1 COX-2


(-)-Epicatechin ((-)-Epicatechol Epicatechin epi-Catechin) Cat No HY-N0001

(-)-Epicatechin inhibits cyclooxygenase-1 ( )COX-1with an of 32 μM (-)-Epicatechin inhibitsIC50

the IL-1β-induced expression of iNOS by blockingthe nuclear localization of the p65 subunit ofNF-κB


(-)-Epicatechin gallate (Epicatechin gallate ECG (-)-Epicatechin 3-O-gallate) Cat No HY-N0002

(-)-Epicatechin gallate (Epicatechin gallate)inhibits cyclooxygenase-1 ( ) with an ofCOX-1 IC50

75 μM

Purity 9857Clinical Data Phase 4Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg

(E)-Ethyl p-methoxycinnamateCat No HY-N0346A

(E)-Ethyl p-methoxycinnamate is a natural productfound in withKaempferia galangalanti-inflammatory anti-neoplastic andanti-microbial effects


(S)-(+)-Ibuprofen ((S)-Ibuprofen) Cat No HY-78131A

(S)-(+)-Ibuprofen is the S(+)-enantiomer ofIbuprofen that inhibits and activityCOX-1 COX-2with s of 21 μM and 16 μM (S)-(+)-IbuprofenIC50

has analgesic antiinflammatory and antipyreticeffects

Purity 9999Clinical Data No Development ReportedSize 500 mg 1 g 5 g

(S)-(+)-Ibuprofen D3 ((S)-Ibuprofen D3) Cat No HY-78131AS

(S)-(+)-Ibuprofen D3 ((S)-Ibuprofen D3) is adeuterium labeled (S)-(+)-Ibuprofen(S)-(+)-Ibuprofen is the S(+)-enantiomer ofIbuprofen that inhibits and activityCOX-1 COX-2with s of 21 μM and 16 μMIC50


(S)-Ketorolac ((-)-Ketorolac) Cat No HY-B0580A

(S)-Ketorolac is a nonsteroidal anti-inflammatoryagent (S)-ketorolac exhibits potent andCOX1

enzyme inhibitionCOX2


2-Hydroxy Ibuprofen ((plusmn)-2-Hydroxy Ibuprofen) Cat No HY-126121

2-Hydroxy Ibuprofen is a metabolite of IbuprofenIbuprofen is an anti-inflammatory inhibitortargeting COX-1 and COX-2 with IC s of 13 μM and50

370 μM respectively






















expressionCOX-2





















210 μgmL




































































































































nM






















NF-κB p65










GW-406381Cat No HY-119304


























































COX-2




COX-2


















LY 178002Cat No HY-101579



































assay





assay




cell assay














































active site(COX)-2
















































RHC 80267 (U-57908) Cat No HY-107416









COX-2 respectively









μM








respectively





S-2474Cat No HY-19212
















































assay

































activity








































expressionCOX-2





















210 μgmL




































































































































nM






















NF-κB p65










GW-406381Cat No HY-119304


























































COX-2




COX-2


















LY 178002Cat No HY-101579



































assay





assay




cell assay














































active site(COX)-2
















































RHC 80267 (U-57908) Cat No HY-107416









COX-2 respectively









μM








respectively





S-2474Cat No HY-19212
















































assay

































activity























210 μgmL




































































































































nM






















NF-κB p65










GW-406381Cat No HY-119304


























































COX-2




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LY 178002Cat No HY-101579



































assay





assay




cell assay














































active site(COX)-2
















































RHC 80267 (U-57908) Cat No HY-107416









COX-2 respectively









μM








respectively





S-2474Cat No HY-19212
















































assay

































activity





















































































































nM






















NF-κB p65










GW-406381Cat No HY-119304


























































COX-2




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LY 178002Cat No HY-101579



































assay





assay




cell assay














































active site(COX)-2
















































RHC 80267 (U-57908) Cat No HY-107416









COX-2 respectively









μM








respectively





S-2474Cat No HY-19212
















































assay

































activity
























NF-κB p65










GW-406381Cat No HY-119304


























































COX-2




COX-2


















LY 178002Cat No HY-101579



































assay





assay




cell assay














































active site(COX)-2
















































RHC 80267 (U-57908) Cat No HY-107416









COX-2 respectively









μM








respectively





S-2474Cat No HY-19212
















































assay

































activity


















































COX-2




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LY 178002Cat No HY-101579



































assay





assay




cell assay














































active site(COX)-2
















































RHC 80267 (U-57908) Cat No HY-107416









COX-2 respectively









μM








respectively





S-2474Cat No HY-19212
















































assay

































activity































LY 178002Cat No HY-101579



































assay





assay




cell assay














































active site(COX)-2
















































RHC 80267 (U-57908) Cat No HY-107416









COX-2 respectively









μM








respectively





S-2474Cat No HY-19212
















































assay

































activity





























assay





assay




cell assay














































active site(COX)-2
















































RHC 80267 (U-57908) Cat No HY-107416









COX-2 respectively









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S-2474Cat No HY-19212
















































assay

































activity











































active site(COX)-2
















































RHC 80267 (U-57908) Cat No HY-107416









COX-2 respectively









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S-2474Cat No HY-19212
















































assay

































activity

























































RHC 80267 (U-57908) Cat No HY-107416









COX-2 respectively









μM








respectively





S-2474Cat No HY-19212
















































assay

































activity


























































assay

































activity





















cox · cox cyclooxygenase cyclooxygenase (cox), officially known as prostaglandin-endoperoxide...

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