GUIDING GOOD IDEASCALENDAR 2013

Design by: colours.no / Text by: BTO / Printed by: HBO

We welcome you to visit us at Marineholmen Technology Park

Bergen Teknologioverføring AS (BTO)Thormøhlensgate 51, 5006 BergenPhone: +47 55 58 30 50Fax: +47 55 58 30 56E-mail: post@bergento.no

WWW.BERGENTO.NO

The University of Bergen www.uib.noHelse Bergen AS www.helse-bergen.no

Institute of Marine Research www.imr.noBergen University College www.hib.no

National Institute of Nutrition and Seafood Research www.nifes.noChristian Michelsen Research AS (CMR) www.cmr.no

UNI Research AS www.uni.noNofima Ingredients www.nofima.no

Global Possibilities- Local Value

This calendar presents a selection of commercialisations based on research carried out at the following

research institutions in Bergen.

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Did you know:That Norway is the world's largest salmon farming

nation, where the western region accounts for 44% of Norway’s total aquaculture production?

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When writing this, BTO is almost 8 years old. A lot has happened during these years, and even though we are proud of what we have achieved together with the brilliant researchers, their institutions and our staff here in Bergen, we know that we are still in the development phase of our services and tools. Looking forward there are some developments that will affect the way BTO operates:

i. The need for a more coordinated and less fragmented Ecosystem for Innovation in our region

BTO AND TELEVENTURE MANAGEMENT CAPITAL VENTURE FUND

Since our start in 22nd of December 2004 BTO has been given more and more responsibilities in the ecosystem for innovation connected to the research institutions in our region. One com-mon challenge in almost all research intensive start-ups is the access to early phase growth capital.

ii. More cooperation amongst BTO and our sister organiza-tions both in Norway and internationally

iii. The need for a wider range of services both when it comes to supporting our researchers - academic services and relating to enhancing regional participation in EU’s Horizon2020

Finally, we also think that new initiatives will be taken to real-ize more of the great potential our marine competence and resources jointly represents.

Together with Kjeller Innovation and NTNU Technology Transfer, BTO have been searching for a concept that would work better alongside our needs. In autumn 2010, Kjeller Inno-vation together with Akershus Teknologifond established the venture fund Norsk innovasjonskapital together with Televen-ture Management, and Norsk Innovasjonskapital II (NIK II) was established in the winter 2011/2012 jointly by Televenture Management and BTO. For BTO, NIK II is our tool to secure better and more stable access to capital and competence for the commercialisation of our most promising projects. Currently, the portfolio consists of 7 innovative companies.

For the investors, NIK II aims to generate the highest possible competitive returns on invested capital through investments, development and exits from selected ventures, as well as to

be a professional and competent business partner. NIK II’s vi-sion is to secure owners a satisfactory capital and management structure for the development and realization of value in early stage ventures.

Having successfully achieved their first milestone in August 2012 of raising over NOK 15 million, NIK II is currently aiming to raise an additional NOK 15 million during their second round of funding. The final round, which will occur during 2013, aims to secure NOK 50 million and to include up to 12 companies.

Looking forward

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Did you know:That included in China’s twelfth five- year plan is to spend 2.2% of GDP on R&D by 2015?

Photo: Jan Haugland,

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es AS

The ACCEL programs are developed and managed by BTO, and offers 5 startup companies the possibility to develop a viable business plan with the assistance from highly quali-fied resources. The companies will get the opportunity to present the business plan to a panel of potential investors and customers. The participants will get practical training in innovation methods and tools. ACCEL was established by BTO in cooperation with NCE Subsea and Bergen University Col-lege during spring 2011. The first program called Subsea First Step was aimed towards the subsea industry. The succeeding evaluation resulted in BTOs increased effort to further develop the program. Since then, the following ACCEL programs have been completed: ACCEL Drilling&Well aimed at the oil and gas industry, ACCEL Mediatech focusing on the media technol-ogy industry, and Subsea Next Step aimed towards established businesses within the subsea industry. ACCEL programs for more business sectors are planned for 2013 and soon to be an-nounced. www.accel.no

Improving quality of life. Research results that are developed into commercial products or services give individuals access to inventions that may improve their quality of life. BTO’s responsibility is to help researchers and research institutions in Bergen commercialize their research results, ensuring that knowledge and inventions benefit individuals, society and industry.

Create your own workplace. You do not need to abandon a career as a researcher in order to create your own business. The two can be combined, and BTO can guide you through your options.

Funding for the research group and the institute. BTO ensures that the researcher and the research environment get their share of profits that arise from the commercialization of the invention.

• BTO services include idea and project development and commercialization and legal advice, available to faculties, researchers and industries.

• BTO provides legal and market expertise, and the core busi-ness is to perform business development within a broad range of areas.

ACCEL - An intensive innovation program for entrepreneurs and established businesses.

Outstanding research – the foundation for innovation!

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Did you know:That mayonnaise was invented in France in 1756, but not

commercialised until 1905 when a German immigrant started selling mayonnaise in glass bottles?

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BerGenBio AS is a newly established, world class biotech com-pany focusing on developing first in class therapeutics to treat aggressive drug resistant and metastatic cancers, by targeting the recently understood epithelial-mesenchymal transition (EMT) process in cancer cells. EMT is the mechanism by which cancer cells escape from the primary tumour, become drug resistant and seed secondary metastatic tumours;

Offering competent assistance. As a general rule, any patentable research result is the property of your employer, i.e. the employing research institution. Consequently, the individual researcher may not freely commercialize his or her invention. This has to do with changes in the Act relating to Universities and University Colleges and in the Employees’ Inventions Act. It is up to the employer to consider whether or not to exercise this right. The assessment is carried out by BTO on behalf of the employer.

• BTO contributes easy access to competent and relevant as-sistance in commercialization to researchers and employers at the research institutions in Bergen.

• Contact BTO if you believe you have an invention. We will then schedule a meeting to guide and inform about your rights and possibilities.

BERGENBIO AS

it is these metastatic tumours that are inevitably fatal for the patient. In a relatively short period of time, the company has achieved leadership status in the EMT and cancer stem cell area.

Originally spun out of the University of Bergen by Professor Jim Lorens, BerGenBio now has a fully integrated research and development infrastructure that discovers and validates novel drug targets in EMT and rapidly develops therapeutics against these. Employing just 4 staff in 2011, BerGenBio has grown to employ 13 scientists, including 8 graduates from UiB, and is currently training 3 industrial PhD students. In fact, BerGenBio provides the most opportunities for those pursuing the indus-trial PhD program of all companies in Norway.

BerGenBio is built on a platform technology developed at UiB called CellSelect, which is used to identify novel drug targets. Based on this technology, the company is building a pipeline of novel EMT targets and first in class cancer drugs.

- Develop novel therapeutics against emerging Cancer targets

1. The tumor induces hypoxic and inflammatory response in the surrounding tissue (small red arrows) 2. Normal tissue induces EMT in the tumor 3. EMT produces Canser Stem Cell traits 4. Cancer stem cells: Invasion, drug resistance and metastatic spread

> Epithelial cells> Basement membrane> Connective tissue

Tumor

The company’s lead program, BGB324, is a first in class AXL in-hibitor that blocks EMT, which is expected to enter clinical tri-als in 2013. The inhibition of tumour cell EMT to reverse drug resistance and increase the effectiveness of established cancer treatments defines a powerful new approach to cancer therapy.

You have an idea – now what?

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Did you know:That the Norwegian coastline is the second longest in the world after Canada, stretching two and a half time around the world?

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When to report your idea to BTO? We recommend that you contact BTO whenever you have discovered something unique with potential commercial value. If you decide to postpone to contact us pending further test results, there is always a risk that somebody else may claim the idea. In that case, you might lose the opportunity to commercialize your invention. Follow-ing the first contact, we will schedule a meeting to guide and inform about you rights and possibilities, and to discuss if you should report your idea. If yes, a DOFI form will be completed by BTOs business developer in cooperation with you. A DOFI form, or Disclosure of Invention, is a description of your inven-tion or development.

A newly developed and novel stereology-based method is now uniquely capable of quantifying mucosal elements of fish skin and in doing so provides industry for the first time with a new tool to quantify and compare the impact of mucosal compe-tence with a number of practical interactions. The quantitative mapping of the skin of fish for the abundance of mucus produc-ing goblet cells monitoring their density, size and distribution

NOVEL METHOD FOR QUANTIFYING MUCOUS CELLS

IN SALMON SKIN

BTO has the competence, experience and network necessary to advise you on the best strategic moment to start a process of commercialization, and handles all reports confidentially.

How to report:• Contact BTO by e-mail, phone or visit us at our office

to schedule a meeting.

• Complete and submit a Disclosure of Invention (DOFI). The form is available at www.bergento.no.

Karin Pittman is a Professor of fish biology in the Fisheries

Ecology and Aquaculture Research Group of BIO. Aurora Campo, MSc, has been working

on the project since autumn 2012.

is essential in promoting a greater understanding of the practi-cal physiology associated with the innate immune system. This technology therefore will enable the quantitative evaluation of practical nutritional strategies, therapeutic interventions and selective breeding on this function. The method is a result of cooperation between industrial partners (Produs, Salmon-Group) and the Dept. of Biology, University of Bergen.

Reporting your invention to BTO

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Did you know:That only 15% of the Norwegian investor

capital goes to companies who work with high technology?

Holberg Score EEG by Harald Aurlien and team 2012: winners - Hordaland County Inventor Award 2010: winners - The Western Norway Regional Health Authority Innovation Award

One2touch by Torbjørn Asen 2012: winner - Young Technology Award, Vebjørn Tandbergs Electric Award, Good Design Award (Japan) 2011: winner - Rosing Award category creativity 2011: runner-up Hordaland County Inventor Award

Professor Helga Salvesen and Professor Lars A. Akslen announced

winners of The Western Norway Regional Health Authority

Innovation Award 2011Photo, top by

Silje Katrine Robinson

AND THE WINNER IS….

Throughout the year, several innovation awards are presented and granted to various well-deserved winners. These awards provide an added value to the winners and their innovation projects beyond the obvious economic benefit. The innovation award provide an opportunity for the researchers to receive acknowledgement for their innovations achievements, atten-tion by their employing organisation/institutes as well as an opportunity to disseminate the results from their research and innovation projects.

Innovation Awards – a valuable acknowledgement

New technology for tailored uterine cancer by Helga Salvesen and Lars A. Akslen 2011: winners - The Western Norway Regional Health Authority Innovation Award 2011: runner-up - Hordaland County Inventor Award

Psychological First Aid Kit by Solfrid Raknes 2012: winner - The Western Norway Regional Health Authority Innovation Award

TextUrgy by Brit Helle Aarskog 2010: runner-up Hordaland County Inventor Award

iSentio by Øyvind Kommedal, Bjarte Karlsen and Øystein Sæbø 2008: winner - Innovation Norway Reodor of the Year 2006: winner - Hordaland County Inventor Award

A selection of commercialization projects stemming from BTO that are winners of various innovation awards, both locally and nationally:

Holberg Score EEG invented by Harald Aurlien and team

announced winners of Hordaland County Inventor Award 2012

Photo, bottom by Tor Erik H. Mathiesen

METAS awarded Subsea Upcoming Company of the Year 2011

Photo, middle by Ole Kristian Olsen, UTC

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Did you know:That there are more than 5000 seafood companies working within the entire seafood value-chain in the western region of Norway?

Should the invention be patented? If the invention or idea can be described as a practical solution to a technical problem, pat-enting may be an option. In order to obtain a patent the inven-tion must be new, differ significantly from previous technology in the area, and be reproducible.

Why protect intellectual property through patenting? Potential commercialization partners often require patent protection to protect the investment required to bring the technology to market. BTO carefully reviews the commercial potential before investing in the patent process. It is important to be aware that

Bio-fuels are a promising alternative for fossil fuel. However, a major problem is that terrestrial feed stocks for ethanol and biodiesel production compete with food production and are therefore not sustainable.

To meet these challenges, researchers at the University of Bergen and UNI Research have proposed the use of Tunicol as a new biomass. Tunicol’s products are ethanol, biodiesel and protein extracted from marine organisms called tunicates. These tunicates are the only animal able to synthesize cel-lulose. Tunicates are found globally in all marine habitats, with a rapid growth potential that far exceeds most terrestrial crops. As tunicates are not a major food web component and do not compete with food production, they are an environmentally friendly biomass for biofuel and animal feed production.

TUNICOL– A sustainable and environmentally friendly biomass for biofuels and animal feed

Demonstrations have been carried out on several locations on the west coast of Norway, and show that they can be success-fully farmed in coastal ocean areas with a significant 3-dimen-sional advantage over other sugar, lipid and protein sources. Tunicates will be cultivated in similar ways as mussels.

Tunicol is set to be commercialized in 2013, where aim is growth and harvest of environmentally friendly biomass for biofuel and animal feed production. Application for a conces-sion was registered fall 2012.

patenting can be an expensive and lengthy process. The formulation of the application and the timing of the appli- cation process could also influence the costs.

• BTO will assist you regarding all questions concerning patenting and commercialization. We have extensive experi-ence and knowledge in patent strategy. We employ external resources with extensive experience in writing patent appli-cations from research environments. Patent applications are always prepared in close collaboration between the researcher, BTO and a patent attorney.

Photo: Tor Erik H. M

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Protecting the invention

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Did you know:That HAV21 launched in 2012 is a project to develop

Norway’s first comprehensive R&D strategy in marine knowledge and management?

Surveys show that implementing innovation methods to the idea stage provide a vast potential and far greater chance of successfully introducing new products, processes and ser-vices to the market. Design-driven innovation employs such an approach and has proven to increase the innovation rate.

BTO believes in the value of a comprehensive approach and has implemented strategic design into our business develop-ment process. We have already coupled design expertise to several of our innovation projects.

An example is the “Salmon lice trap” developed by scientists at the institute of Marine Research. This project was the first selected to receive design expertise and funding through a new collaborative program by the Research Council of Norway FORNY2020 and Norwegian Design Council. This design program is available to projects from Norwegian tech-nology transfer offices, and the aim is to help enterprises and public institutions become more innovative by using design-driven methods. The design program was introduced in 2011 and is continued with increased funding and efforts in 2012 and hopefully 2013.

Having cooperated over several months with designers on the salmon lice trap, and subsequently launching the result, research leader and inventor Howard Browman has no doubt that design is a natural part of research-based innovation. “Connect with designers as early as possible,” advises Browman to other inventors.

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DESIGN-DRIVEN INNOVATION

– Part of BTOs business development process

“We are scientists and have no experience doing anything like this ourselves. Through this process, it has become clear to us that contact with designers early in the process would have changed the type of questions we would have raised during the research. The questions would have been directed less by our own curiosity and more by the needs of a product.” HOWARD BROWMAN

“The pilot project in 2011 proved to be very valuable and inter-esting for all parties involved. We have therefore amplified our effort during 2012 with a fivefold increase of invested resources, meaning more accessible funding for each project and more ef-fort into design as a means of increasing the innovation rate.” ANNE KJERSTI FAHLVIK

“Our focus is on linking designers, and their competence, with the basis of research initiatives to bridge the gap with the market. That’s why we believe it is important for the Norwegian economy if the Norwegian Design Council and competent designers can contribute to revolutionizing the innovation rate of Norwegian research.“ JAN R. STAVIK

Research leader and inventor of Salmon Lice Trap, Institute of Marine Research

Executive Director, Research Council of Norway, Division for Innovation

Managing Director, Norwegian Design Council

Experiences with Design Pilot 2011

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Did you know:That a patent is not a right to use the invention, but a right to exclude others from making, using, selling, eg. the patented invention?

Protecting the commercial value of your intellectual property. As a researcher you are free to publish your results at any time. But if you consider patenting the invention, you must not make your invention public before the patent application is filed.

Patenting and publishing can be coordinated. Patenting your idea before you publish it, need not cause a significant delay in the publication process. However, it is crucial that everything is done in the right order. If you publish your research results

Professor Vidar R. Jensen and researcher Giovanni Occhipinti have collaboratively developed a new class of catalysts for the 2005 Nobel Prize winning catalytic chemical reaction, olefin metathesis. They recently discovered catalysts may turn out to be useful for the production of new kinds of plastics, phar-maceuticals, and complex natural products. The main benefit offered over existing catalysts is selectivity, which facilitates more efficient production with less hazardous waste .

For chemical manufacturers, using catalysts with high selectiv-ity is vital towards ensuring that only the desired product is formed during chemical reactions. As synthesis routes become shorter, more of the desired product and less of the unwanted product can be produced, leading to cleaner and more environ-mentally friendly production. In this manner, selective catalysts can, for instance, be used to produce polymers with special properties such as very strong and resistant plastic for use in windmill rotor blades.

With the aid of molecular simulations using supercomputers, Jensen and Occhipinti have cost-efficiently identified and sin-gled out for synthesis only those molecular catalyst structures with the highest probability of success in practice. Their cata-lysts consist of a molecular complex built upon the rare metal ruthenium. Generally speaking, when two alkenes react they form geometric isomers. One product is termed a cis-isomer and the other a trans-isomer. Certain industrial applications require only one of the products. The catalysts developed by Jensen and Occhipinti can give up to 95% cis-isomers, while today’s commercially available catalysts typically produce an overweight of trans-isomers.

The goal of the researchers is to reach a catalyst offering 100% selectivity. Funds from FORNY and the Norwegian Research Council are being used to further develop these catalysts in order to achieve this goal.

NEW SELECTIVE OLEFIN METATHESIS CATALYSTS

Photo: Tor Erik H. M

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before filing a patent application, you will ruin your chances of obtaining a patent.

• BTO’s aim is to complete the commercialization process without delaying your academic publication.

• If you consider patenting, contact BTO before publishing your research results.

Patenting and publishing

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Did you know:That the former British Prime Minister

Margaret Thatcher is co-inventor of soft serve ice cream?

Nyskapingsparken Incubator is knowledge, network, and office space with an infrastructure which is put to disposition for startup businesses. The goal is to give the startups a quicker and safer way from establishment to growth. The target group is newly founded businesses sprung out from the academic and scientific environments in Hordaland with a great growth potential and grade of innovation.

Nyskapingsparken provide the entrepreneurs with help to develop their business through courses, seminars, consulting

and guiding. Admission is accepted twice a year, and the time limit for keeping the office space is three years. The startup companies at the incubator works mainly within the focus areas technology, software, and subsea/petroleum.

Nyskapingsparken has 23 offices, two conference halls and social areas, and is BTOs neighbor at Marineholmen Technol-ogy Park. Nyskapingsparken and BTO have established a close relationship, which includes a formal agreement where we exchange expertise to offer a broader service to the entrepre-neurs. The common goal is to help the entrepreneurs succeed with their businesses. The co-localisation has resulted in a good culture for cooperation, as well as a low threshold of shar-ing knowledge and network.

– Collaborating to increase the innovation rate

NYSKAPINGS-PARKEN

INCUBATOR AND BTO

Intellectual Property Rights (IPR) is a broad term that com-prises different kinds of legal protection of ideas, inventions, characteristics etc. These forms of protection have the follow-ing in common:

• A documented protection secures your exclusive right to exploit your invention commercially.

• Ownership is clarified through licensing. When meeting with potential collaborators you may safely present technical

details concerning the product without risking that other parties pick up the ideas.

• Future discussions concerning ownership are avoided.

Forms of protection:• Patenting, registered trademark and design, copyright.

Keys to protecting your intellectual property

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Did you know:That Thomas Edison filed 1,093 patents, including those for the light bulb, electric railways and the movie camera.

Conflicts of interest (COI) include a variety of situations in which an employee is faced with conflicting loyalties, and may arise when personal economic interests conflict with the duties toward the research institution.

Some examples:• If a professor that is supervisor for a student owns a com-

pany, and the research performed by the student is relevant for the company

• If your research group establishes a company based on their research result, and the research institution/research group buys products and services from this company.

The Continuous Laryngoscopy Exercise Test (CLE) is an inno-vative test utilizing a continuously video-recorded laryngosco-py during ongoing intensive treadmill exercise. Simultaneous external video and audio recordings are taken in order to more effectively differentiate exercise-induced asthma from other forms of exercise-induced dyspnea or exercise-related obstruc-tions of central airways. Effectively diagnosing patients leads to a significant reduction in the cases of inappropriate treatment, negative side effects, and overall expenses involved. The CLE test is the first method, in which continuous visualization of the larynx during exercise has been successful.

Diagnosing the obstruction of central airways is quite difficult, and differentiating exercise induced asthma from other com-mon causes of similar symptoms is not well defined. The ability

to properly diagnose patients requires the laryngeal function to be visualized during on-going exercise. Until now, patients were examined via post-exercise laryngoscopy, which not only elevated the rate of panic and negative tests, but also gave limited information regarding what had provoked the laryngeal obstruction since the response was already present when the endoscope was introduced.

The CLE test revolutionizes diagnosticity in that it facilitates video recorded laryngoscopy throughout a complete, maximal exercise test. Visualizing the larynx from the beginning of symptoms and throughout subsequent development of the exercise session enables proper identification of the structures inciting and perpetuating the obstruction. Clinical studies prove the test to be safe and well-tolerated by patients.

CLE– A New Method to Study Central

Airway Abnormalities

• If a faculty member recommends that a graduate student pursue research in an area that would benefit the commer-cialisation of a product of a company in which the faculty member has a financial interest.

Most conflict situations that are of concern and allowable under the law can be handled through disclosure and the setting of appropriate conditions and monitoring requirements.

• BTO takes this problem seriously, and we have a proactive, professional approach to identify and handle potential COI’s in our portfolio.

Photo: Tor Erik H. M

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Conflict of interest

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Did you know:That the can opener was invented

48 years after cans were introduced.

Material Transfer Agreements (MTA) are agreements which regulate the physical transfer of research material between two institutions, where the intention of the receiver is to make use of the material in his own research.

An MTA regulates the rights and duties that are imposed on the sender and receiver of such material, and possible elaborations and diversions of this. The most common transfer is the transfer of biological material, such as the transfer of cell lines, reagents and vectors.

Oil and gas companies are in great need for equipment that can detect leaks of oil and gas from subsea installations at an early stage. Marine Ecosystem Technologies AS (METAS) is targeting these challenges, and is developing acoustic based products and systems that enable the petroleum industry to satisfy the upcoming demands by authorities. METAS aims to become the first supplier to offer this kind of equipment.

METAS develop and produce technological marine monitoring solutions using acoustic technology.

METAS has developed various categories of products and applications that together meet most of the requirements from the customers data collection needs. The unique modular design of their monitoring system make possible the acoustic based basis module to be used in all of their products, and to

Photo: Tor Erik H. M

athiesen

MTA’s can also be used for the transfer of other material, for instance chemical components and even some kinds of software.

It is important that you contact and consult BTO if you are go-ing to enter an MTA, as these agreements will often lay down guidelines and restrictions on the rights to future commercial exploitation of the research results. BTO can in collaboration with the right authority at your employer’s help, negotiate terms of agreement that restrict these possibilities as little as possible.

METAS- Solutions for subsea monitoring and

acoustic data collection

easy develop and produce solutions to individual specifications at a competitive rate. METAS deploy and monitor these sys-tems worldwide. The products are produced and manufactured in the Bergen region, with local suppliers for most of the parts needed. This is a result of the METAS ideology and business strategy to support local business and contribute to create new regional employment opportunities.

METAS has achieved positive revenue each year since the founding in 2009, despite substantial investments in R&D dur-ing the same period. In 2010, METAS moved to new and larger facility, fully equipped and provides capacity to enable growth in the company. At the moment, METAS employ 6 persons, including 1 industrial PhD. Further expansion of staff is sched-uled to happen in 2013.

Material Transfer Agreement

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Did you know:That BTO has been involved in commercializing 86 projects from research institutions in Bergen since 2005?

The poster above shows a broad range of spin-off companies stemming from the research institutions in Bergen, including the spin-offs established by BTO. Some of these companies are now successful enterprises, and some have recently concluded major international deals. And several of the companies have already made an impact on the region by providing jobs and opportunities for existing businesses, and create value back to the institutions. Today, BTO has several innovative technolo-gies in the pipeline that are available for investment.

We look forward to continue and improve our collaboration with the regional business partners, and to work with present and future researchers with innovative ideas. We believe that the closer we get the industry and research institutions to work together, the more commercial opportunities will come our way.

• At BTO we believe that most of the world’s great ideas have yet to be put into life. Have you got an idea?

BTO guiding good ideas

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