Think Smart. Think Sharp.A breakthrough solution for brain health

• Natural brain building block• Clinically proven• Long term effect• Variety of grades and applications• Easy to consume• Excellent organoleptic properties

Children & StudentsSupporting brain health and development

AdultsMaximizing potential and achievements

Cognitive Needs Throughout the LifespanBrain health is one of the major public health concerns at all ages. Children and students today are growing in a very competitive academic environment and parents are committed to supporting their mental performance and helping them achieve the highest academic results.

Adults are looking for a way to keep their brain healthy and well nourished in order to enable their brain to work at top capacity, and seniors seek to lessen loss of cognitive skills and abilities as part of the aging process. Clinical studies have demonstrated that Phosphatidylserine (PS) supplementation may improve mental performance and contribute to maintaining a healthy life style.

SeniorsHealthy lifestyle

The Role of Phosphatidylserine in the BrainPS has a crucial contribution to the structure and function of the nerve cells and plays a key role in 'cell to cell' communication, information transfer, signaling etc3-5.

PS Composition of Human Tissues1 (as % of total phospholipids)

of theBrain

of theHeart

of theLiver

3% 3%18%

What is Phosphatidylserine (PS)?Phosphatidylserine (PS) is one of the body's essential building blocks. It is naturally found in the cell membrane and particularly abundant in the brain1. The brain is a very metabolically active organ and is one of the richest organs in lipid content2.

Human Brain Brain

CellsPS

Molecule

Information Transfer

SERINE

PHOSPHATE

GLYCEROL

FATT

Y AC

ID

1

FATT

Y AC

ID

2

Cell-to-CellCommunication

PS in our Diet

Clinical studies demonstrate beneficial effects for supplementing our daily diet with 100–300 mg /day of PS

PS is a natural nutrient, it can be found in our food

chain and exists in mother’s milk.6

PS is found abundantly in the internal organs of

animals and some types of fish. However, the

modern diet contains low levels of PS7.

-48%

250mg/day

Pre-1980’s

180mg/day

Enriched Diet(meat/fish)

100mg/day

Reduced Fat Diet130mg/day

Current Avg.

50mg/day

Vegeterian Diet

Daily Intake of PS is Reduced in Modern Diets

*

****

**

*

PS Health Benefits

Consumption of Sharp PS® Improves Cognitive Functions8

PS health benefits have been proven in over 30 clinical studies

addressing the entire human life cycle, from seniors8, adults9 to

children10,11. PS was found to significantly improve:

Soy PS in Milk Improves Cognitive Functions of Students9

Published in: Richter et al, Clinical Interventions in Aging. 2013; 8, 557

Published in Chinese in: Tang Yong et al, Chongqing medical journal, 2011

95

90

85

80

75

70

65

60

40

35

30

25

20

15

10

Mea

n Sc

ore

(poi

nts)

Te

st S

core

(poi

nts)

MemoryRecognition

MemoryRecognition

Associative Learning

Free Memory of Images

Recognitionof Meaningless Figures

PortraitFeatures-Linked Memory

BASELINE

6 WEEKS

PS BEFORE

PS AFTER

12 WEEKS

n=26, Age: 50-90Treatment: 300mg/day* p<0.01**p<0.006

n=120, Age: 17-18Treatment: 300mg/dayPS provided in milk* p<0.05

MentalFlexibillity

Executive Functions

MemoryRecall

*

*

**

*

Concentration, Memory, Attention, Learning,

Behavior, Stress Management.

A Leading Phosphatidylserine Brand for CognitiveFunction

Enzymotec has exclusive and patented Sharp-PS® grades

Sharp-PS® has excellent organoleptic properties

Enzymotec is currently the only supplier that has next generation products in the market

Enzymotec Introduces

Sharp-PS® is easily applicable in dairy matrix – UHT or milk formula

Produced by Enzymotec, a leading PS supplier, Sharp-PS® is one of the most popular supplements in the industry, representing the highest quality and greatest variety of grades

CERTIFIED

ISLAMIC FOOD AND NUTRITION COUNCIL OF AMERICA

Why is PS the Best Cognitive Solution? PS is the only cognitive supplement that demonstrates crucial contribution to the structure and function of brain cells.

Brain Boosters Oxidation & Inflammation

Membranes structure

Products:Ginkgo Biloba, Ginseng, Coffee/Energy drinks

Activity:Immediate, short term effect

Products:Vitamins & Minerals, Anti oxidants, DHA

Activity:Indirect support to inflammation & oxidation influence on the brain

Products:PS and other phospholipids

Activity:Direct long term clinically approved effect on cognitive performance

G.M.P

CERTIFIED QMS

SIISO 9001:

2008

THE STANDARDS INSTITUTION OF ISRAEL

F

OOD

SAFE

TY MANAGEMENT SYSTEMHACCP

THE STANDARDS INSTITUTION OF ISRAEL

• Sharp-PS® is certified by:

PS gained two approved FDA* claims:Consumption of phosphatidylserine may reducethe risk of cognitive dysfunction in the elderly

Consumption of phosphatidylserine may reducethe risk of dementia in the elderly

Sharp PS® is Suitable for a Wide Range of Applications

Softgels

Capsules

Liquid Furmula /

UHT Milk

Milk Powder

Gummies

NEWLY LAUNCHED!

Sharp PS® SILVER - is a natural brain energizer for

sharp thinking, focused activities, mood

improvement and enhanced concentration. Sharp

PS® SILVER delivers significant amounts of PS and

DHA, reduces stress and anxiety.

Additive effect for PS and DHA may be observed

when consumed simultaneously.

Soy PS + Fish Oil

GREEN

Sharp PS GREEN™ - is one the most revolutionary and

innovative new products in the field of brain health.

It is comprised of phosphatidylserine from vegetarian source

which is free from soy allergens, a non GMO and eco

friendly. Sharp PS GREEN™ was developed by Enzymotec

and helps maintain and restore memory and mental

performance.

Sunflower PS

Next Generation of Enzymotec PS Products Source

SILVER

®

Available GradesSharp PS® SilverSharp PS Green™Sharp PS®

20% and 60%20-70% for GM 20-85% for non-GMPowder

20%20%Fluid

10%18%20 and 28%Dispersion

With EU health claim for brain

Exclusive Complex of PS & Omega-3

Additivecognitive effects of PS & DHA

Soy-Allergen Free

Attributes Benefits Specific advantages

Proven to support

mental performance

& cognitive abilities

at all ages, from

school age children

to adults with

memory complaints.

Long term effects on

memory, learning &

focus

Grades available for multiple applications including dairy products

References:1. White, D. The phospholipid composition of mammalian tissue,1973

2. Woods et al, AAPS Journal, 2006.

3. Mozzi R., et al. Neurochem Res. 2003;28:195-214.

4. Pepeu G., Pharmacol Res. 1996;33:73-80

5. Vance JE et al. Progress in lipid research. 2005; (44)207-34.

6. Bitman , et al. American journal of clinical nutrition, 1984, 40:(1).

7. M. Hamm, Statement on the change of nutritive provision with PS, 2002

8. Richter et al, Clinical Interventions in Aging. 2013; 8:557

9. Yong, T., Chongqing Medicine, 2011, 30:3022-3023,3026.

10. Manor, I., European Psychiatry, 2012, 27(5):335-42.

11. Hirayama, S., Journal of Human Nutrition and Dietetics, 2014, 27 (Suppl. 2):284-91.

* Very limited and preliminary scientific research suggests that phosphatidylserine may reduce

the risk of cognitive dysfunction in the elderly. FDA concludes that there is little scientific

evidence supporting this claim.

RegulationsSharp PS® has gained regulatory approval in the following countries:• USA• Europe• China• Australia

www.enzymotec.com

Enzymotec values

Contact Information

Headquarters:Sagi 2000 Industrial Park, P.O. Box 6

Migdal HaEmeq 23106, Israel.

Tel: +972 74 717 7177

Fax: +972 74 717 7001

Email: info@enzymotec.com

China Office:Enzymotec China R.O.

3011-3012 Room South Building,

Fortune plaza, No.1839 Qixin Rd,

Shanghai 201100 P.R China

Tel: +86 21 6040 9725

Fax: +86 21 6040 9730

Email: infochina@enzymotec.com

U.S.A Office:Enzymotec USA, Inc.

A subsidiary of Enzymotec Ltd.

55 Madison Avenue, Suite 400

Morristown ,NJ 07960

Tel: +973 912 9400

Fax: +973 912 9500

Email: infousa@enzymotec.com

Australia Office:Enzymotec Australia PTY LTD

PO Box 1250

Menai Central NSW 2234

Australia

Tel: +61 0 434 633 185

Email: claudetteC@enzymotec.com

Enzymotec's Edge

• Global leader in lipids technologies

• Clinically-validated products that address dietary needs, medical disorders and common diseases, using molecules familiar to the human body

• Proprietary, scalable technology platform and clinical research capabilities integrated across segments

• A unique product range that addresses the entire human life cycle from infancy to old age

• Solutions that cover the entire health spectrum from prevention to treatment, from nutrition to drugs (Rx)

• Fully integrated – R&D, Process Development, Manufacturing, Regulation, Marketing and Sales