THE SC IENCE BEHIND YOUR PRODUCTS

Company OverviewDeNova : A Proven Technology From NTU

PERSONAL CARE INDUSTRY OUTLOOKANIMAL TESTING BAN GAINING WORLDWIDE MOMENTUM

2014

IN-VITROHUMAN SKIN MODEL

EX-VIVOHUMAN SKIN EXPLANT

2016

IN-VIVOCLINICAL TRIAL

2018

Bringing Value to CustomersCREATE A ONE STOP ASIAN SKIN TESTING SOLUTION

We licensed the Compromised (Dry) In-Vitro Skin Model from NTU exclusively in

2014.

We Launched the Skin Testing Services using the In-vitro Skin Platforms in

DeNova Testing lab.

ASIAN-SPECIFIC SOLUTIONKNOW OUR STRENGTH & KNOW THE MARKET

ASIA has been revealed as Leader of Global Skincare Sales.

Consumers Awareness on Asian Specific Tested Products has been Fast Increasing leading to

Skincare Company developing Product lines specific for Asian.

Research & Product

Development

Pre-Clinical

Studies

Bringing Value to Customers

Clinical

StudiesRegulation

Consultancy

OUR UNIQUE ONE STOP SOLUTION

Product

Registration

Product

Manufacture

DeNova expertise revolves around in-vitro and ex-vivo Organoid solutions and innovations for Asian market.

We are well connected in Singapore with Universities, Research Institutes and a wide array of SME &MNC.

Our strategic location in Singapore allows for open-collaborative efforts between different entities for technology exchange.

FORSTERING A TRUSTED PARTNERSHIPEMPOWERING A BETTER FUTURE

Outsourced R&D

Reduces your financial

expenses and expertise

limitation with our team of

ethical and committed

scientist.

Collaboration

We welcome any

opportunities for scientific

collaboration and business

expansion that enhance

DeNova’s growth.

Commercialization

We provide a platform to

accelerate your research from

bench to market.

One Stop Skin Testing

From in-vitro to clinical

testing, we provide a ONE-

STOP solution for your

skincare products.

1 STOP SKIN SOLUTIONEnhance The Science Behind Your Product

ONE-STOP DERMATOLOGY SOLUTIONACCELERATING YOUR SUCCESS

DeNova provide TAILOR-MADE SOLUTION for your product

with the latest Skin Technology and Innovation that provide you

with evidence proved SCIENCE.

In-vitro Skin Technology

Suitable for Early Stage

Research & Development,

Screening Platform and

Pilot Idea Testing.

Ex-vivo ASIAN Human Skin

We Offered Asian Human

Skin Explants Suitable for

Pre-Clinical Validation for

Testing and Claim Support.

ASIAN Clinical Trial

We co-ordinate your

Clinical Testing with our

Partner in INDONESIA. STAGE STAGE STAGE

IN-VITRO SKIN PLATFORMACCELERATING YOUR RESEARCH

In-vitro Skin Technology

Suitable for Early Stage

Research & Development,

Screening Platform and

Pilot Idea Testing.

STAGE

DN Skin Model

EX-VIVO SKIN PLATFORMVALIDATE PRODUCT EFFICACY

Ex-vivo ASIAN Human Skin

We Offered Asian Human

Skin Explants Suitable for

Pre-Clinical Validation for

Testing and Claim Support

STAGEAsian Origin

Different Colour Tone

Different Ethnicity

2-4 Hr after Excised

Post Treatment

CLINICAL TRIAL (INDONESIA)ACCELERATING YOUR PRODUCT COMMERICALIZATION

ASIAN Clinical Trial

We provide the Clinical

Testing through our exclusive

Partner in INDONESIA.

STAGE

Sensory and Efficacy Evaluation

Sensory

FeelEfficacy

Irritation

Smell

SKIN TESTING SERVICESTAILORABLE SOLUTION

Penetration

Adhere to OECD TG428

Guideline using in-vitro

or human skin.

Assess formulation

Performance,

Penetration ability of

Actives, and delivery

system Efficacy.

Toxicity &

Sensitization

Adhere to OECD TG 431

and 439 using DN in-vitro

skin or EURL ECVAM

validated skin from

Episkin or MatTek.

Assess actives or finished

product’s Safety.

Skin Lightening

Offer in-vitro co-culture

system and human skin

explant model for the

study of skin

pigmentation.

Assess actives or

product’s Whitening/

Tanning potential.

Environmental

Stress

Offer UVA/ UVB treated

cellular model and

Reactive Oxidative Stress

induced model.

Assess actives or

product’s ability to

Protect from External

Stress

Skin Function

Offer testing model

ranging from in-vitro

culture to ex-vivo human

skin explant model to

investigate skin function.

Assess actives or

product’s effect on

specific Skin Function

COLLABORATION /FUTURE INSIGHTCollaborate To Accelerate Research and Science Advancement

3D SKIN PRINTINGEnhance Reproducibility and

Scalability. Reduce the need

of Skilled Labor and Cost.

IMMUNE SKINExploring the Field of

Reprogramming of Stem Cell to

Create World 1st In-Vitro Skin with

Immune/ Allergy Response.

Targeting both the Personal Care,

Medical Device and

Pharmaceutical Industries.

AGED SKIN Global Aging represent one of Today’s Best

Business Opportunities. Aged Skin Model will

allow better understanding and efficacy

testing of Personal Care and Healthcare

products/ devices.

MICROFLUIDIC PENETRATION

ASSAYAim to replace the traditional Franz Cell

Penetration system with reduced cost and skin

limitation.

ACTIVE COLLABORATIONTO ENHANCE OUR TECHNOLOGY & CAPBILITIES AND ACCELERATE RESEARCH

3D BIOPRINTINGNEW CUTTING EDGE TECHCollaborate To Accelerate Research and Science Advancement

3D BIO-PRINTING COLLABORATIONFRONTING NEW TECHNOLOGY

LIVER SPEROID PRINTINGSKIN PRINTING

3D-PRINT SKINFRONTING NEW TECHNOLOGY

Kera

tin

ocy

te

(Ep

iderm

al)

Fib

rob

last

(Derm

al)

Printed 3D SKIN cultured on Serum-Free System

3D-Print (Day 4) 3D-Print (Day 10)

SKINTopical Application of Drug/ Skincare

HEARTContractility & Conduction

KIDNEYExcretion

LIVERMetabolism of Drugs & Toxicity Accumulation

LUNGAbsorption of

Aerosol-borne Drug

GUTSystemic Absorption of Drugs & Nutrients

IMMUNE SYSTEMImmune Response

A System To Evaluate Systemic Toxicity(R&D)

7 TXR

PREDICTION

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