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Introduciendo la nanotecnología en el mercado cosmético Judith Sendra R&D Director Endor Nanotechnologies www.yen-effect.com

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Page 1: The in vitro choice j sendra_2013

Introduciendo la nanotecnología en el mercado cosmético

Judith SendraR&D Director

Endor Nanotechnologies

www.yen-effect.com

Page 2: The in vitro choice j sendra_2013

Advanced Metallic NanoparticlesOrganic MoleculesMetallic Nanoparticles

Designing advanced metallic nanosystems.

Endor is a nanotechnology company developing innovative products for human health using metallic nanoparticles

Page 3: The in vitro choice j sendra_2013

"Leading edge nanomaterials for oncologic anddermatological treatments"

ONCOLOGY DERMATOLOGY

www.yen.effect.com

Page 4: The in vitro choice j sendra_2013
Page 5: The in vitro choice j sendra_2013

Expresión de Has2 en Queratinocitos

100,00

154,83

105,39

0

50

100

150

200

C- Hyatreat HA

In vitro

Voluntarios

Expresión de Has2 en Fibroblastos

100

162,84

98,41

020406080

100120140160180200

C- Hyatreat HA5

Pruebas de eficacia

Page 6: The in vitro choice j sendra_2013

Toxicidad

Page 7: The in vitro choice j sendra_2013
Page 8: The in vitro choice j sendra_2013

SCCS/1484/12

Page 9: The in vitro choice j sendra_2013

Guidance on the safetyassessment of Nanomaterials

in CosmeticsSCCS/1484/12

Ingrediente Cosmético

Contiene material nano

Sí

No

Evaluación de la exposición

Eva

luac

ión

de s

egur

idad

gen

eral

(no

nan

o)

Exposición sistémica

SíNo

Efectos LocalesNo

Sigue siendo NanoNo Sí

Identificación de riesgos y dosis-

respuesta

Evaluación de riesgos

Sí

Page 10: The in vitro choice j sendra_2013

Evaluación de la exposición

Page 11: The in vitro choice j sendra_2013

Fluido Receptor: 0%

Evaluación de la exposición

No hay exposición sistémica

Page 12: The in vitro choice j sendra_2013

Efectos Locales

Citotoxicidad

Mutagenicidad/Genotoxicidad

Patch Test HET CAM

Know-How Interno

Colaboraciones (UTOX)

Subcontratación

Dosier de Seguridad

Page 13: The in vitro choice j sendra_2013

0

20

40

60

80

100

120

c- 1% 3% 10% 25% 50% 75% 100%

GH

% V

iabi

lidad

Citotoxicidad

0

20

40

60

80

100

120

c- 1% 3% 10% 25% 50% 75% 100%

GH

% V

iabi

lidad

Fibroblastos (HDF) Keratinocitos (HACAT)

Page 14: The in vitro choice j sendra_2013
Page 15: The in vitro choice j sendra_2013
Page 16: The in vitro choice j sendra_2013
Page 17: The in vitro choice j sendra_2013

Perfil Toxicológico del Nanomaterial

Page 18: The in vitro choice j sendra_2013

Expediente de Información sobre el producto

Page 19: The in vitro choice j sendra_2013

www.yen-effect.com

Gracias


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