Download - The in vitro choice j sendra_2013
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Introduciendo la nanotecnología en el mercado cosmético
Judith SendraR&D Director
Endor Nanotechnologies
www.yen-effect.com
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Advanced Metallic NanoparticlesOrganic MoleculesMetallic Nanoparticles
Designing advanced metallic nanosystems.
Endor is a nanotechnology company developing innovative products for human health using metallic nanoparticles
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"Leading edge nanomaterials for oncologic anddermatological treatments"
ONCOLOGY DERMATOLOGY
www.yen.effect.com
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Expresión de Has2 en Queratinocitos
100,00
154,83
105,39
0
50
100
150
200
C- Hyatreat HA
In vitro
Voluntarios
Expresión de Has2 en Fibroblastos
100
162,84
98,41
020406080
100120140160180200
C- Hyatreat HA5
Pruebas de eficacia
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Toxicidad
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SCCS/1484/12
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Guidance on the safetyassessment of Nanomaterials
in CosmeticsSCCS/1484/12
Ingrediente Cosmético
Contiene material nano
Sí
No
Evaluación de la exposición
Eva
luac
ión
de s
egur
idad
gen
eral
(no
nan
o)
Exposición sistémica
SíNo
Efectos LocalesNo
Sigue siendo NanoNo Sí
Identificación de riesgos y dosis-
respuesta
Evaluación de riesgos
Sí
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Evaluación de la exposición
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Fluido Receptor: 0%
Evaluación de la exposición
No hay exposición sistémica
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Efectos Locales
Citotoxicidad
Mutagenicidad/Genotoxicidad
Patch Test HET CAM
Know-How Interno
Colaboraciones (UTOX)
Subcontratación
Dosier de Seguridad
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0
20
40
60
80
100
120
c- 1% 3% 10% 25% 50% 75% 100%
GH
% V
iabi
lidad
Citotoxicidad
0
20
40
60
80
100
120
c- 1% 3% 10% 25% 50% 75% 100%
GH
% V
iabi
lidad
Fibroblastos (HDF) Keratinocitos (HACAT)
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Perfil Toxicológico del Nanomaterial
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Expediente de Información sobre el producto
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Gracias