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Spring 2017 • Volume 12 • Issue 1

Spring 2017 The GI Digest 1

Chief ObservationsChief Observations 1

Past, Present and Future 2

Dr. Carethers 3

Dr. Conjeevaram 4

Dr. Merchant 5

DDW Awards and Recognition 6

Distinguished Abstract and Presidential Plenary Sessions 8

Moderators 9

Research and Topic Forums 11

Symposia 15

AGA and ASGE Postgraduate Courses Breakfast with the Expert, Poster Tours 17

Daily Schedule 18

Poster Sessions 24

Index 30

The DDW 2017 Issue

Michigan Medicine Gastroenterology and Hepatology faculty, fellows, research scientists and mid-level providers will converge at Digestive Disease Week in Chicago, IL from May 6–9, 2017. Recognized as one of the top 50 medical meetings by HCEA, Digestive Disease Week® is the world’s largest gathering of physicians, researchers and industry working in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery. DDW provides an unparalleled opportunity for our Division to showcase to our peers throughout the world the many accomplishments we have achieved over the past year. Our strong tradition of

leadership and recognition at DDW continues this year.I am proud to announce that three of our faculty will receive prestigious AGA

awards: Dr. John Carethers will receive the AGA Distinguished Mentor Award, Dr. Hari Conjeevaram, the AGA Distinguished Educator Award, and Dr. Juanita Merchant, the Distinguished Achievement Award in Basic Science. Dr. Shrinivas Bishu will receive the 2017 AGA–Pfizer Pilot Research Award in Inflammatory Bowel Disease. We are also very proud of the many division faculty serving in leadership roles to organize this year’s DDW program. Dr. Grace Elta continues to serve as the chair of the AGA Council. Her committee is responsible for organizing all the programming for DDW. At the section level, Dr. John Kao is the vice chair of the Esophageal, Gastric, and Duodenal Disorders Section; Dr. Joel Rubenstein chairs the Clinical Practice Section; Dr. Linda Samuelson is the vice chair of the Cellular & Molecular Gastroenterology Section; and Dr. John Wiley is the vice chair of the Neurogastroenterology and Motility Section.

The Division again has a strong showing at DDW, reflected in the number of presentations by our faculty and fellows. We have 59 platform presentations – notably, presentations at a Distinguished Abstract Plenary and the Presidential Plenary and 5 state-of-the-art lectures – and 64 posters. The wide range of important topics that will be covered include stem cell biology, epithelial cell differentiation and morphogenesis, visceral hypersensitivity, gastroparesis, gut microbiome, inflammatory bowel disease, gastric metaplasia, intestinal mucosal inflammation and fibrosis, colon and pancreatic cancer, and hepatitis B. Many of our faculty will serve as forum and symposium moderators, participate in panel discussions and Breakfast with the Expert, and conduct AGA and ASGE Postgraduate Courses.

Faculty and Fellows in the News at DDW 2017

the GI DigestDepartment of Internal Medicine, Division of Gastroenterology and Hepatology

UM GI & Hepatology Alumni ReceptionSaturday, May 66:30 – 10:00 pm

Camelot Room, 3rd floor InterContinental Chicago Magnificent Mile

AGA Awards CeremonySunday, May 75:30 – 6:30 pm • reception6:30 – 7:15 pm • award presentationsGrand Ballroom, 7th floor InterContinental Chicago Magnificent Mile

ASGE Crystal AwardsSunday, May 76:15 pm • reception7:30 pm • dinner and programRadisson Blu Aqua Hotel

DDW 2017 Receptions

2 The GI Digest Spring 2017

Gastroenterology and Hepatology at the University of Michigan

Past, Present and Future of Innovation, Clinical Practice and LeadershipIn September 2016, the Division of Gastroenterology and Hepatology celebrated the 75th anniversary of the founding of the Division. As part of that celebration the Division held a two-day symposium, “GI and Hepatology at the University of Michigan: Past, Present and Future of Innovation, Clinical Practice and Leadership.” Faculty, fellows, alumni, U-M leadership and friends of the Division were invited to attend.

The Thursday program, moderated by Drs. Chung Owyang and William D. Chey, included Dr. John Carethers, followed by leaders in gastroenterology and hepatology from across the nation, including Drs. Tachi Yamada, Rick Boland and David Lieberman. Distinguished alumni speakers included Drs. Ezra Burstein, Joseph Elmunzer, Michael Kochman, Uri Ladabaum, John Inadomi and Michael Lucey.

The Friday program, moderated by Dr. Juanita Merchant, showcased the achievements of some of our own U-M faculty, including Drs. Anna Lok, Liz Speliotes, John Allen, John Wiley, Peter Higgins, William Chey, Hari Conjeevaram, Thomas Wang, Jason Spence and Nobu Kamada. Mary Petrovich, a philanthropist and friend of the Division, was also on hand to give her personal reflection on patient care and the future of innovation.

On Friday, Medicine Grand Rounds was presented by a special guest, Dr. Daniel K. Podolsky, President of UT Southwestern Medical Center.

The Symposium was followed by a dinner at the beautiful University of Michigan Museum of Art. After a reception, which showcased a five-panel work of art by Bill Burgard that was commissioned for the event, Chung Owyang welcomed guests and introduced Dr. Joel Howell who led guests along an interesting journey of the history of the University and the Division. A video produced just for the occasion was shown, after which Dr. Chey introduced remarks by Drs. James Woolliscroft, Tachi Yamada and Daniel Podolsky. The final toast of the night was given by John Carethers who announced the establishment of the Chung Owyang, MD, Professorship in Gastroenterology and Hepatology. This endowed chair is intended to support future chiefs of the U-M Division of Gastroenterology and Hepatology and will ensure that Dr. Owyang’s legacy of dedication will live on at the University of Michigan in perpetuity.

The history of the Division, from the modest beginning in the 1940s, to the tailgate and football game attended by guests of the 75th Anniversary Celebration, has been artfully captured in a 184-page book, “Honoring the Past, Shaping the Future: 75 Years of Discovery, Innovation and Care”.

Past, Present and Future

https://leadersandbest.umich.edu/find/#!/give/basket/fund/799605

https://leadersandbest.umich.edu/find/#!/give/basket/fund/799605

http://www.med.umich.edu/gi/docs/75th_Anniversary.pdf

http://www.med.umich.edu/gi/docs/75th_Anniversary.pdf

DDW 2017 Awards and Recognition

We are proud to announce the following award recipient from the University of Michigan Division of Gastroenterology and Hepatology who will be recognized at DDW 2017.

John M. Carethers, MD, AGAFDistinguished Mentor awardAmerican Gastroenterological Association

AGA is proud to honor John M. Carethers, MD, AGAF with a Distinguished Mentor Award, which recognizes individuals who have made lifelong efforts dedicated to the mentoring of trainees in the field of gastroenterology and for achievements as outstanding mentors throughout their careers.Dr. Carethers' continuous dedication to achieving excellence, his mentorship of GI fellows, postdoctoral fellows, medical students (both in clinical education and in medical research), and undergraduate students, and his rigorous, yet highly supportive style make him deserving of this award. He has an infectious enthusiasm for research and scholarly work and for the field of gastroenterology at large. Dr. Carethers is the John G. Searle Professor and Chair, Department of Internal Medicine and Professor of Human Genetics at Michigan Medicine. He oversees more than 820 faculty, 310 trainees and 1,700 staff. He is a trained gastroenterologist and physician–scientist who focuses his research on colon cancer genetics. He has served as a role model and mentor to GI-focused scientists and clinicians worldwide, and has mentored 56 trainees at all academic levels, with 17 currently holding faculty positions. Among his many mentoring/teaching awards are the University of California, San Diego (UCSD) Department of Medicine Graduating House Staff Teaching Award (1999) and the UCSD Vice-Chancellor’s Award for Mentoring Excellence (2006). Numerous additional honors include membership to the National Academy of Medicine (2012), American Association for the Advancement of Sciences (2015), and the American Academy of Arts & Sciences (2016). An AGA member for over 25 years, Dr. Carethers has contributed tremendously to the organization. He has served on the Underrepresented Minorities Committee and Research Policy Committee, and as vice chair and chair of the AGA Institute Council Gastrointestinal Oncology Section, as well as chair of the section’s nominating committee. He served as a senior associate editor for Gastroenterology, and served as the program chair and as an invited speaker for numerous AGA meetings. In 2016, he received the AGA Institute Gastrointestinal Oncology Section Research Mentor Award. From 2015 to 2016, he served as a mentor for the inaugural class of the AGA Future Leaders Program and as a mentor for the AGA Investing in the Future Student Research Fellowship. Dr. Carethers serves as chair of the Minorities in Cancer Research Council of the American Association for Cancer Research, and is a councilor and soon to be president-elect of the American Association of Physicians. He completed a two-year appointment on the National Commission for Digestive Diseases. Dr. Carethers is an elected member of the American Society for Clinical Investigation, the American Association of Physicians, and the National Academy of Medicine. He has published more than 160 manuscript articles and book chapters that focus on colorectal cancer. Dr. Carethers received his MD with high distinction from Wayne State University. He completed his internship and residency in internal medicine at Massachusetts General Hospital followed by a GI fellowship at U-M. At UCSD, he conducted research on DNA mismatch repair and colorectal cancer pathogenesis, was GI division chief (2004–2009), served as founding director of its NIH-funded GI center, and was the director of the GI NIH T32 grant. He also served as PI of the NIH-funded San Diego State University/UCSD Cancer Center Comprehensive Partnership, which addresses cancer disparities.




Hari S. Conjeevaram, MD, MSDistinguished Educator AwardAmerican Gastroenterological Association

AGA is proud to honor Hari S. Conjeevaram, MD, MS with the AGA Distinguished Educator Award, which recognizes individuals who have made outstanding contributions as educators in gastroenterology on both local and national levels, over a lifelong career.

Dr. Conjeevaram has dedicated his entire academic career to the education, mentorship and empowerment of medical students, residents and fellows. He has been selfless in these efforts and his trainees consider him a shining example of the ideal physician and exemplary educator they aspire to become.

He serves as director of the GI Fellowship Training Program and has been actively involved in teaching leadership skills to students through his role as medical director for the University of Michigan student-run free clinic. Dr. Conjeevaram has won numerous awards from the University of Michigan for his teaching, mentorship and humanism in medicine. He has received the H. Marvin Pollard Award for Outstanding Teaching of Residents, the Gold Foundation Leonard Tow Humanism in Medicine Award twice and has been voted Best Teaching Attending six times in his career. He was the only University of Michigan faculty member selected as a faculty inductee in the Alpha Omega Alpha Honor Medical Society in 2015, and received Michigan’s nomination for the Association of American Medical Colleges National Humanism in Medicine Award.

Dr. Conjeevaram is active in the education of medical students, residents and fellows globally. He has been instrumental in setting up a Memorandum of Agreement for education and training for medical students, residents and GI fellows at the All India Institutes of Medical Sciences, New Delhi, India. His involvement with the Indian Society of Gastroenterology has allowed him to mentor GI and hepatology trainees from many institutions in India.

As an educator, Dr. Conjeevaram continually looks to the future. Through the Global Health and Education platform at the University of Michigan, he leads an educational collaborative initiative focusing on GI fellows' education and training in Ethiopia. Additionally, he is currently working with fellows and faculty to design a “New Educational Pathway” for GI fellows that focuses on innovative methods of teaching and educating fellows, including technology-based teaching, self-learning modules and competency assessment in endoscopy training. In summary, Dr. Conjeevaram is most deserving of the AGA Distinguished Educator Award.

Dr. Conjeevaram obtained his medical degree from Madras Medical College, University of Madras, Tamilnadu, India. He completed his master of science in epidemiology and biostatistics at the School of Public Health, University of Michigan, Ann Arbor, Michigan. Dr. Conjeevaram joined the Division of Gastroenterology at the University of Michigan in 2001 as an assistant professor of medicine and has been a professor of medicine since 2013.




Juanita L. Merchant, MD, PhDDistinguished Achievement Award in Basic ScienceAmerican Gastroenterological Association

AGA is proud to honor Juanita L. Merchant, MD, PhD, with the Distinguished Achievement Award in Basic Science, which recognizes a senior investigator who has made major accomplishments in basic science research that has significantly advanced the science and/or practice of gastroenterology.Dr. Merchant’s discoveries in the field of transcription factors and its application to gastric physiology and pathophysiology are among her many achievements deserving recognition. Dr. Merchant is the H. Marvin Pollard Professor of Gastrointestinal Sciences, a Professor of Internal Medicine and Integrative and Molecular Physiology, and Associate Director of the MD/PhD Medical Scientist Training Program at the University of Michigan. Dr. Merchant began her undergraduate research career after her sophomore year at Stanford University studying lipid metabolism in the rat ileum. She completed her medical degree and PhD in cell biology at Yale University School of Medicine. After completing an internal medicine residency at Massachusetts General Hospital, she returned to the laboratory as a physician–scientist to study the transcriptional control mechanisms underpinning homeostatic and neoplastic development in the luminal GI tract and subsequently completed her clinical fellowship in gastroenterology at the University of California, Los Angeles. Dr. Merchant began her research career by asking a simple, but fundamental question in gastroenterology – how does the hormone gastrin sense acid and maintain homeostasis in the stomach? This question has been the basis of her research for nearly 25 years. Among Dr. Merchant’s foremost achievements are her studies of hedgehog signaling in the stomach during homeostasis and neoplastic transformation. In short, studies from Dr. Merchant’s laboratory have remained exciting, cutting edge and focused on the regulation and downstream targets modulated by elevated gastrin. Dr. Merchant was one of the first assistant investigators in gastroenterology in the Howard Hughes Research Institute, Chevy Chase, MD. She was selected to be a Harold Amos scholar by the Robert Wood Johnson Foundation, a program that supports the transition of minority physicians to careers in academic medicine. At the University of Michigan, Dr. Merchant was recognized when she was transitioning from assistant to associate professor with the Jerome Conn Award, which is given to a junior faculty who shows the most promise in research and mentorship. She has participated on the AGA Research Committee, the AGA Nominating Committee, and the AGA PhD, MD/PhD, DVM Committee, and was chair of the Hormones, Transmitters, Growth Factors, and Their Receptors Section of the AGA Institute Council. She has served on several NIH study sections, including chair of the Molecular Gastroenterology Study Section. Subsequently, she served on the NIDDK Council and was an initial member of the Council of Councils. She currently serves on the NIDDK Board of Scientific Review. Dr. Merchant has been elected into prestigious medical honor societies, including the American Society for Clinical Investigation and the National Academy of Medicine (NAM). Few gastroenterologists or scientists in the field of gastroenterology are members of NAM, further highlighting Dr. Merchant’s outstanding research career over the years and qualifications for this AGA award.



Tossapol (Tos) Kerdsirichairat, MD2017 AGA–GRG Fellow Abstract Prize American Gastroenterological Association (AGA) and Gastroenterology Research Group (GRG)

This award encourages trainees to become more involved in digestive disease research.


Shrinivas Bishu, MDAGA–Pfizer Pilot Research Award in Inflammatory Bowel DiseaseAmerican Gastroenterological Association (AGA) Research Foundation and Pfizer Inc.

This award supports pilot projects proposed by investigators interested in exploring new research directions in inflammatory bowel disease.

Ryan J. Law, DOASGE Cook Medical Don Wilson Award American Society for Gastrointestinal Endoscopy (ASGE)

This award provides advanced fellows or junior faculty with the opportunity to train outside of their home country with a premier GI endoscopist or group in order to advance their training.

DDW Awards • 2008–2017


Richard J. Saad, MD, MSAGA Research Scholar Award

Michael L. Volk, MD, MScAGA Research Scholar Award

DDW 2008

DDW 2010Tadataka Yamada, MDAGA Distinguished Mentor Award

Anna S. Lok, MD, FRCPAGA Foundation for Digestive Health and NutritionOutstanding AGA Women in Science Award

Juanita L. Merchant, MD, PhDAGA Foundation for Digestive Health and NutritionOutstanding AGA Women in Science Award

DDW 2009

DDW 2011Chung Owyang, MD AGA Distinguished Mentor Award

Joel H. Rubenstein, MD GRG/AGA Young Investigator Award in Clinical Science

James M. Scheiman, MD AGA Institute Council Section Mentor AwardEsophageal, Gastric & Duodenal Disorders Section

ASGE Senior Investigator Mentoring Award

Andrea Todisco, MD AGA Research FoundationR. Robert and Sally Funderburg Research Scholar Award in Gastric Biology Related to Cancer Biology

DDW 2012John Del Valle, MDAGA Distinguished Educator Award

Grace H. Elta, MDAGA Institute Council Section Mentor AwardImaging and Advanced Technology Section

Timothy T. Nostrant, MDAGA Distinguished Clinician Award

DDW 2013Grace H. Elta, MDAGA Distinguished Clinician AwardASGE Distinguished Educator Award

Chung Owyang, MDAGA Julius Friedenwald Medal

Joseph C. Kolars, MDAGA Distinguished Educator Award

Richard S. Kwon, MD, MSAGA–Covidien Research and Development Pilot Award in Technology

Juanita L. Merchant, MD, PhDAGA Institute Council Section Mentor AwardRegulatory Peptides, Cell Signaling & Molecular Biology Section

M. Bishr Omary, MD, PhDAGA Institute Council Section Mentor AwardLiver and Biliary Section

Linda C. Samuelson, PhDAGA Institute Council Morton I. Grossman Lectureship

John A. Williams, MD, PhDAGA Distinguished Achievement Award

DDW 2014

DDW 2015William D. Chey, MDAGA Distinguished Clinician Award

M. Bishr Omary, MD, PhDAGA Distinguished Mentor Award

DDW 2016Anna S. Lok, MD, FRCPAGA William Beaumont Prize in Gastroenterology

DDW 2017John M. Carethers, MDAGA Distinguished Mentor Award

Hari S. Conjeevaram, MD, MSAGA Distinguished Educator Award

Juanita L. Merchant, MD, PhDAGA Distinguished Achievement Award in Basic Science

Distinguished Abstract and Presidential Plenary Sessions

AGA • Cellular & Molecular GastroenterologyDistinguished Abstract Plenary

2:06 PM S105a

Regulation of CD44 expression by bone morphogenetic protein (BMP) signaling and inflammatory stimuliWei Ye, Hidehiko Takabayashi, Yitian Yang, Maria Mao, Linda Samuelson, Elise Demitrack, Fung-yu Huang,Kent-Man Chu, Wai Leung, Andrea Todisco

Sunday, May 7, 2017


Monday, May 8, 2017

AGA • Presidential Plenary

11:29 AM S406

Hepatitis B elimination: Is it possible?Anna Lok

Moderators

8:00 – 9:30 AM • AGA Research Forum S105bcdMechanisms of host–mucosal response to injury and H. pylori infectionModerators: Mohamad El-Zaatari, Nicola Jones

8:00 – 9:30 AM • AGA Translational Symposium S102dMetabolic diseases of the liver in adultsModerators: Robert Fontana, Ronald Sokol

8:00 – 9:30 AM • AGA Research Symposium S102abcBasic science: Solving clinical conundrums in IBDModerators: Peter Higgins, Gerhard Rogler

8:00 – 9:30 AM • ASGE Clinical Symposium S401Small bowel challengesModerators: Michael Rice, Carol Semrad

8:00 – 9:30 AM • AGA Clinical Symposium S406bPost-ERCP pancreatitisModerators: Jacques Van Dam, Erik-Jan Wamsteker

11:30 AM–2:00 PM • ASGE Hands-On Workshop South HallSuturing and ClosuresModerator: Juanita Merchant

2:00 – 3:30 PM • ASGE Clinical Symposium S404ERCP optimizing cannulation and outcomes –Techniques and controversiesModerators: Michelle Anderson, David Jaffe

2:00 – 3:30 PM • AGA Clinical Symposium S406bChronic pancreatitis, diabetes and pancreatic cancer: NIH ConsortiumModerators: Darwin Conwell, Matthew DiMagno

2:00 – 3:30 PM • AGA Translational Symposium S102abcIntestinal Metaplasia in the Esophagus and Stomach: Highlights of the 2016 Freston ConferenceModerators: Robert Genta, Juanita Merchant

Saturday, May 6, 2017


2:00 – 3:30 PM • AGA Research Symposium S105aMechanisms of Mucosal RepairModerators: Yatrik Shah, Shanthi Srinivasan

4:00 – 5:30 PM • AGA Research Forum S403bEndoscopic qualityModerators: Megan Adams, Lukejohn Day

4:00 – 5:30 PM • AGA Research Forum S406aAdvances in diagnosis and treatment of IBSModerators: Shanti Eswaran, Lucinda Harris

4:00 – 5:30 PM • AGA Clinical Symposium S502Kristin and David Peura, MD, Lecture: Help! I can’t get rid of H. pyloriModerators: Emad El-Omar, John Kao

4:00 – 5:30 PM • AGA Clinical Symposium S105bcdLinking quality and reimbursement in IBDModerators: Ziad Gellad, Akbar Waljee


Sunday, May 7, 2017

8:00 – 9:30 PM • AGA Research Forum S100cIBD: Comparative effectiveness studiesModerators: Christina Ha, Ryan Stidham

10:00 – 11:30 PM • AGA Research Forum S101aFunderburg Symposium: 25 Years of Gastric Cancer ResearchModerators: C. Richard Boland, Juanita Merchant

2:00 – 3:30 PM • AGA Clinical Symposium S501Beyond sporadic colorectal cancer and esophageal adenocarcinoma: Controversies in screening for the “other” GI cancersModerators: Loren Laine, Joel Rubinstein

continued next page

Moderators

Tuesday, May 9, 2017

8:00 – 9:30 AM S102dAGA Committee Sponsored Symposium

Tales from the front lines: How GI practices are using quality measurement to drive improvementModerators: Megan Adams, Ziad Gellad

8:00 – 9:30 AM S104AGA Distinguished Abstract Plenary

The Best of Barrett’s, EOE, GERD, H. pyloriModerators: John Kao, Michael Vaezi

10:00 – 11:30 AM • AGA Research Forum E354aIBD: Controlled Clinical Trials Moderators: Peter Higgins, William Sandborn

10:00 – 11:30 AM S502AGA Distinguished Abstract Plenary

Clinical PracticeModerators: Paul Moayyedi, Joel Rubenstein

10:00 – 11:30 AM • AGA Research Forum S503H. pylori: Epidemiology, outcomes and treatmentModerators: Ernst Kuipers, Richard Saad

2:00 – 3:30 PM • AASLD Research Forum S403aHealth-Care in the Hospital and Clinic for Chronic Liver Disease Moderators: Kiran Bambha, John Magee

2:00 – 4:00 PM • DDW Clinical Symposium S100cThe Best of DDW 2017 Moderators: Steven Edmundowicz, Grace Elta


8:00 – 9:30 AM • AGA Clinical Symposium S105aTaking back power: Options for organizing physicians to enhance bargaining powerModerators: Megan Adams, John Allen

10:00 – 11:00 AM S405AASLD State-of-the-Art Lecture

DILI: Is this pill safe to swallow?Moderators: Robert Fontana, Folasade (Fola) May

10:00 – 11:30 AM • AGA Research Forum S100cOutcomes in IBDModerators: Gil Melmed, Akbar Waljee

2:00 – 3:30 PM S105aAGA Distinguished Abstract Plenary

Cellular and Molecular GastroenterologyModerators: Charalabos Pothoulakis, Linda Samuelson

4:00 – 5:30 PM • AGA Research Forum S403bUpper GI bleeding and appropriate use of PPIsModerators: David Armstrong, Jacob Kurlander

4:00 – 5:30 PM S403aAASLD Clinical PlenaryModerators: Kimberly Brown, Anna Lok

4:00 – 5:30 PM S102abcAGA Basic Science PlenaryModerators: Linda Samuelson, Jerrold Turner

4:00 – 5:30 PM S104AGA Distinguished Abstract Plenary

Neurogastroenterology and MotilityModerators: Satish Rao, John Wiley

Sunday, May 7, 2017

Monday, May 8, 2017

8:00 AM S405Current diagnoisis of IBS with diarrhea William Chey

8:00 AM S104MAZ promotes colitis-associated colon tumorigenesis through regulation of STAT3 signaling Daniel Triner, Yatrik M. Shah

8:15 AM S104Nuclear-to-cytosolic shuttling of the DNA mismatch repair protein MSH3 requires posttranslational modification and interacts with an inflammation-related cytosolic complex Stephanie Tseng-Rogenski, Koji Munakata, Supal Mehta, Mamoru Uemura, Tsunekazu Mizushima, Masaki Mori, Minoru Koi, John Carethers

8:30 AM S406aValidation of a tool predicting complications on cross-sectional imaging among young inpatients with Crohn’s disease Jeffrey Berinstein, Jeremy Adler, Akbar Waljee, Ryan Stidham, Julajak Limsrivilai, Peter Higgins, Shail Govani

9:00 AM S105bcdDendritic cell–derived TGF-β mediates the induction of Helicobacter-specific regulatory T cell response essential for maintenance of immune tolerance in miceMin Zhang, Mohamad El-Zaatari, Kathryn Eaton, Helmut Grasberger, John Kao

9:15 AM S104AGA State-of-the-Art Lecture

Inflammatory signaling networks driving gastrointestinal carcinogenesisYatrik Shah



Research and Topic Forums


11:15 AM S105aTranscription factor ZBP-89 cooperates with β-catenin in the Lgr5+ stem cellRamon Ocádiz-Ruiz, Michael Hayes, Juanita Merchant

2:15 PM S105bcdClustering of esophageal cancer mortality among white men in the United StatesJoel Rubenstein

2:30 PM S100abMachine learning models at week 6 of vedolizumab therapy for ulcerative colitis can accurately predict week 52 corticosteroid free endoscopic remissionAkbar Waljee, Boang Liu, Kay Sauder, Ji Zhu, Shail Govani, Ryan Stidham, Peter Higgins

4:00 PM S106Absent in melanoma 2 (AIM2) deficiency exacerbates pseudopyloric metaplasia during chronic Helicobacter infection, due to an accumulation of CD8+ T cells in the gastric mucosaMohamad El-Zaatari, Min Zhang, Nobuhiko Kamada, Shrinivas Bishu, Helmut Grasberger, John Kao

4:15 PM S403bAppropriateness of surveillance interval in non-dysplastic Barrett’s esophagusAnna Tavakkoli, Chaitra Madiyal, Henry Appelman, Maryam Khodadost, Kimberly Nofz, Val Metko, Grace Elta, David Beer, Thomas Wang, Joel Rubenstein

5:15 PM S403bAGA State-of-the-Art Lecture

Should ADR be the one and only measure of colonoscopy quality?Sameer Saini



Sunday, May 7, 2017

8:00 am S103Prevalence and predictors of IBS-like symptoms in the United States: Results from a survey of over 71,000 AmericansChristopher Almario, William Chey, Brennan Spiegel

9:00 AM S103Tryptophan hydroxlase 1 (TPH1) promoter genotype but not serum serotonin levels identify IBS-D patients more likely to benefit from the low FODMAP dietShanti Eswaran, Juanita Merchant, Amanda Photenhauer, Kenya Jackson, Dennis Madriaga, Fabiyola Selvaraj, Fred Princen, William Chey

10:06 AM S106Recurrent acute pancreatitis without underlying overt chronic pancreatitis negatively impacts quality of lifeGregory Cote, Dhiraj Yadav, Judah Abberbock, Gong Tang, Adam Slivka, Randall Brand, Michelle Anderson, Peter Banks, Michele Lewis, John Baillie, Stuart Sherman, Samer Alkaade, Stephen Amann, Andres Gelrud, Chris Forsmark, Bimaljit Sandhu, Nalini Guda, Darwin Conwell, Thiruvengadam Muniraj, C. Mel Wilcox, David Whitcomb, Timothy Gardner

4:15 PM S403bPoor adherence to recommendations to prevent gastrointestinal bleeding among anticoagulation clinic patientsJacob Kurlander, Xiaokui Gu, James Scheiman, Brian Haymart, Eva Kline-Rogers, Sameer Saini, Scott Kaatz, Steve Almany, Michael McNamara, Jay Kozlowski, James Froehlich, Geoffrey Barnes

5:15 PM S101bButyrate regulates transcription factor ZBP-89 and sustains proliferation under low glucose conditionsRamon Ocádiz-Ruiz, Michael Hayes, Juanita Merchant

Monday, May 8, 2017

8:12 AM S100cAutonomic function in gastroparesis: Relationship with etiology, gastric emptying and symptom severityLinda Anh Nguyen, Laura Wilson, William Hasler, Pankaj Pasricha, William Snape, Henry Parkman, Irene Sarosiek, Richard McCallum, Kenneth Koch, Gianrico Farrugia, Madhusudan Grover, Braden Kuo, Laura Miriel, James Tonascia, Frank Hamilton, Thomas Abell

8:24 AM S100cRelationship of symptoms of gastroparesis to gastric pathophysiology Henry Parkman, Perry Orthey, Mark Van Natta, Alan Maurer, Daohai Yu, Frederick Ramsey, Jesus Diaz, Paige Clark, Andrei Iagaru, Roberto Fragomeni, William Hasler, Gianrico Farrugia, Kenneth Koch, Linda Anh Nguyen, William Snape, Thomas Abell, Richard McCallum, Irene Sarosiek, John Clarke, Laura Miriel, James Tonascia, Frank Hamilton, Pankaj Pasricha

8:36 AM S100cReduction in symptoms during provocative meal testing with insulin pump therapy plus continuous glucose monitoring in patients with gastroparesis due to poorly controlled diabetes: Relation to gastric myoelectrical activity Kenneth Koch, William Hasler, Jorge Calles-Escandon, Mark Van Natta, William Snape, Pankaj Pasricha, Linda Anh Nguyen, Henry Parkman, Richard McCallum, Irene Sarosiek, Thomas Abell, Gianrico Farrugia, Madhusudan Grover, Frank Hami

9:00 AM S503How cost affects the treatment choice for irritable bowel syndrome with diarrhea patients: A cost-effectiveness analysis of tricyclic agents and rifaximin Eric Shah, Elizabeth Andraska, Jonathan Li, Sai Zhang, William Chey

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9:12 AM S100cAGA State-of-the-Art Lecture

Gastroparetic symptoms, symptom score and diagnostic tests – What do they tell and how useful? William Hasler

9:15 AM S102dSoluble protein p40 produced by Lactobacillus rhamnosus GG enhances tight junction protein expression and improves epithelial integrity by preventing alteration of DNA methylation and histone acetylation in human colonoids Xu Han, Ji-Yao Li, Sha Huang, Jason Spence, Chung Owyang

10:30 AM S100cDefining patient-centered outcomes for IBD and an international, cross-disciplinary consensus Andrew Kim, Charlotte Roberts, Brian Feagan, Rupa Banerjee, Willem Bemelman, Keith Bodger, Marc Derieppe, Axel Dignass, Richard Driscoll, Ray Fitzpatrick, Peter Higgins, Paulo Kotze, Jillian Meissner, Marian O’Connor, Zhihua Ran, Corey Siegel, Helen Terry, Welmoed van Deen, Christien Janneke Van Der Woude, Alandra Weaver, Suk-Kyun Yang, Bruce Sands, Severine Vermeire, Simon Travis

10:45 AM S501Clinical profile of early and late onset idiopathic chronic pancreatitis (ICP) and the influence of known genetic factors Michele Lewis, David Whitcomb, Jyothsna Talluri, Judah Abberbock, Andres Gelrud, Peter Banks, Timothy Gardner, Stephen Amann, Stuart Sherman, Bimaljit Sandhu, Samer Alkaade, Vikesh Singh, Darwin Conwell, Gregory Cote, Nalini Guda, Chris Forsmark, Charles Wilcox, Thiruvengadam Muniraj, Gong Tang, John Baillie, Randall Brand, Adam Slivka, Michelle Anderson, Dhiraj Yadav

Monday, May 8, 2017 Monday, May 8, 2017

10:45 AM S403bMorphomics-based risk stratification model predicts complications after pancreaticoduodenectomy for pancreatic cystic neoplasmsAlexander Larson, Binu Enchakalody, Nicholas Wang, Diane Simeone, Hari Nathan, Clifford Cho, Stewart Wang, Grace Su, Richard Kwon

11:15 AM S100cAGA State-of-the-Art Lecture

Behavioral therapies as an adjunct for management of IBDMegan Riehl

2:00 PM S401AASLD State-of-the-Art Lecture

Hepatitis B treatment: Current status and prospects for a cureAnna Lok

2:15 PM S104Hedgehog pathway activation protects the colon during inflammatory colitisMichelle Muza-Moons, Audrey Urquhart, Deepa Chandhrasekhar, Deborah Gumucio

2:30 PM S404Outcomes of multiple gateway versus single gateway transluminal endoscopic drainage and necrosectomy in patients with necrotizing pancreatitis and walled-off necrosis (WON) using lumen-apposing metal stents: results from an endoscopic step-up approach cohortTossapol Kerdsirichairat, Stuart Amateau, J. Shawn Mallery, Guru Trikudanathan, Rajeev Attam, Sidney Walker, Gregory Beilman, Martin Freeman, Mustafa Arain

4:24 PM S102dSerum 7C4 levels decrease after low FODMAP diet in IBS patients: A potential mechanism for benefitShanti Eswaran, Fabiyola Selvaraj, Fred Princen, Patty Tooker, Gulia Harvie, William Chey




8:15 AM S404Scoring system developed from an eight-year cohort of a consistent transluminal endoscopic step-up approach for walled-off necrosis (WON) to predict new onset diabetes mellitus (WON-DM score) in patients undergoing endoscopic intervention for walled-off necrosisTossapol Kerdsirichairat, Stuart K. Amateau, Sidney Walker, Mustafa A. Arain, Rajeev Attam, Gregory Beilman, Guru Trikudanathan, Martin L. Freeman

10:30 AM S405Antiviral therapy is under-utilized but associated with improved survival across tumor and liver disease stages and cancer therapies in HBV-related hepatocellular carcinoma (HCC): Results of a multicenter United States–Asia cohort of 2307 patientsVincent Chen, Ming-Lun Yeh, An Le, Peggy Tsai, Mijung Jun, Waqar Saeed, Hyo Young Lee, Pauline Nguyen, Nathan Kim, Chia-Yen Dai, Jee-Fu Huang, Chung-Feng Huang, Wan-Long Chuang, Dae Won Jun, Young-Suk Lim, Ming-Lun Yu, Mindie Nguyen

10:45 AM S405Significantly lower rates of cirrhosis and lower long-term survival in cryptogenic hepatocellular carcinoma (HCC) compared to viral etiologies: Results of a multi-center international cohort Tomi Jun, Ju Dong Yang, Ming-Lun Yeh, Vincent L. Chen, Pauline Nguyen, Minh Chung, Nasra H. Giama, Chung-Feng Huang, Chia-Yeh Dai, Jee-Fu Huang, Wan-Long Chuang, Ming-Lun Yu, Lewis R. Roberts, Mindie H. Nguyen

10:54 AM S503Efficacy of high-dose dual therapy versus bismuth-containing quadruple therapy for first-line treatment of Helicobacter pylori infection and an interim report of multi-center, randomized control studyChi-Tan Hu, Chien-Chih Tung, Chun-Jung Lin, I-Nan Kuo, Bor-Ru Lin, Hong-Long Wang, Jin-De Chen, Mu-Liang Cheng, Chia-Tung Shun, Huei-Mi Li, Jui-Sheng Hung, Wei-Yi Lei, Ming Jium Shieh, Jau-Min Wong, John Kao, Jyh-Chin Yang


11:00 AM S101aBile acids regulate intestinal paneth cell functions and contribute to gut dysbiosis induced by high fat feeding Hui Zhou, Merritt Gillilland, Jun Gao, Shi-Yi Zhou, Guanpo Zhang, Chung Owyang

2:36 PM S106Gastrointestinal motility and luminal pH influence in vivo dissolution and systemic absorption of drug product in human gastrointestinal tract under fed and fasted conditions Mark Koenigsknecht, Jason Baker, Ann Fioritto, Yasuhiro Tsume, Bo Wen, Joseph Dickens, Alex Yu, Jeffery Wysocki, Kerby Shedden, Barry Bleske, Allen Lee, William Hasler, Gordon Amidon, Duxin Sun

3:00 PM S405Serum concentrations of cartilage oligomeric matrix protein are correlated with the presence of advanced hepatic fibrosis in untreated hepatitis C Ryan Stidham, Akbar Waljee, Peter Higgins, Anna Lok

3:00 PM S102dChronic stress-associated abdominal pain: Glucocorticoid receptor mediates interleukin 6–induced down-regulation of epithelial tight junction protein occludin and enhanced visceral painYe Zong, Shengtao Zhu, John Wiley, Shuangsong Hong

3:15 PM S403aThey do hurt more: A nationwide study of falls and injury among patients with cirrhosisGhideon Ezaz, Elliot Tapper

5:00 PM S101bPGE2 produced by mast cells is critical to induce visceral hypersensitivity in IBS Gintautas Grabauskas, Xiaoyin Wu, Kim Turgeon, Chung Owyang


8:40 AM • AGA Clinical Symposium S100cHow can we impact clinical and research policy?John Allen

9:00 AM • AGA Clinical Symposium S100cPanel Discussion

Gastroenterology in the Age of TrumpSpencer Dorn, Folasade (Fola) May, John Allen, F. Taylor Wootton, Michael Roberts, Kathleen Teixeira

10:44 AM • AGA Clinical Symposium S100cFODMAPs diet – 10 years on and still ticking!William Chey

4:15 PM • AGA Clinical Symposium S502Kristin and David Peura, MD, Lecture: Help! I Can’t Get Rid of H. Pylori

Discussion 2: How to optimize treatment to achieve success with salvage therapy including role of H. pylori culture and sensitivityWilliam Chey


8:00 AM • ASGE Clinical Symposium S503GWC Symposium 2017: Leveling the Playing Field

Current gender and diversity inequities in gastroenterologyGrace Elta

10:43 AM • AGA Research Symposium S101aFunderburg Symposium: 25 Years of Gastric Cancer Research

Notch pathway induction of gastric tumorigenesisLinda Samuelson

2:00 PM E350Rodger C. Haggitt Gastrointestinal Pathology Society Symposium

Getting the Most Out of Your Pathologist: Three Illustrative Cases

A rash diagnosis of inflammatory bowel diseaseJohn Hart, Jami Kinnucan

4:05 PM • AGA Committee Sponsored Symposium S102dAdding value to your practice: Three trends you should know

Evolving businees models of GI careJohn Allen

5:05 PM • AGA Committee Sponsored Symposium S102dPanel Discussion

Adding value to your practice: Three trends you should knowJohn Allen, Ryan Madanick, Keisa Lynch

Sunday, May 7, 2017

Symposia



Symposia

Monday, May 8, 2017

8:00 AM • AGA Committee Sponsored Symposium S102dSetting the stage: The importance of quality measures in driving improvement in GIJohn Allen

9:15 AM • AGA Committee Sponsored Symposium S102dPanel Discussion

Tales from the front lines: How GI practices are using quality measurement to drive improvement Ziad Gellad, Megan Adams, John Allen, James Leavitt, Fasiha Kanwal, Steven Carpenter, Corey Siegel

10:30 AM • AGA Research Symposium S105aMenin-MLL inhibitor MI-503 suppresses plasma gastrin in a mouse model of hypergastrinemia Sinju Sundaresan, Michael Hayes, Jolanta Grembecka, Juanita Merchant

10:54 AM • ASGE Clinical Symposium E350Imaging: The Next Generation of Optical Diagnostics

In vivo molecular imaging Thomas Wang

4:00 PM • AGA Clinical Symposium S402ASGE/Chinese Society of Gastroenterology (CSGE) International Symposium

Management of anti-thrombotics in elective and emergency endoscopy Michelle Anderson

8:00 AM • AGA Clinical Symposium S105aHistory of physicians organizing in the United StatesJohn Allen

8:18 AM • AGA Clinical Symposium S105aLegal considerations governing physician unionizationMegan Adams

9:12 AM • AGA Clinical Symposium S105aPanel Discussion

Taking Back Power: Options for Organizing Physicians to Enhance Bargaining PowerJohn Allen, Megan Adams, Fred Rosenberg, F. Taylor Wootton

2:30 PM • AGA Clinical Symposium S105aEarly onset colorectal cancer: What’s in your genes?Elena Stoffel

3:06 PM • AGA Clinical Symposium S105bcdManagement of low grade dysplasia: Surveillance or endoscopic therapy?Joel Rubenstein

4:00 PM • Best of AGA at DDW in Chinese S403bInflammatory Bowel Disorders John Kao

4:15 PM • ASGE Clinical Symposium S401Special Situations in Endoscopy

Pregnancy (ERCP, sedation)Grace Elta

4:54 PM • AGA Committee Sponsored Symposium S101aThe Road to Leadership in GI

Private practice pioneers and how to be oneJohn Allen

5:12 PM • AGA Committee Sponsored Symposium S101aQuestions and Answers

The Road to Leadership in GISheila Crowe, Kim Barrett, Michael Nathanson, John Allen

DDW Breakfast With the Expert

6:30 – 7:45 AM S405STAT scope: Approach to endoscopic emergenciesMichelle Anderson, John Martin

Sunday, May 7, 2017


AGA Postgraduate Course Luncheon Breakout Sessions

11:45 AM E253bHealth care advocacy and legislative changesJohn Allen


1:25 PM • AGA Postgraduate Course Arie Crown TheaterGeneral Session III – The Biliary Tree and Pancreas

The Full Scope of GI Advances (Day 1)

Chronic pancreatitisMatthew DiMagno


7:45 am • ASGE Postgraduate Course S100abBest Tips, Worst Mistakes: Lessons From the Masters, Day Two

Optimal strategies for managing incidental pancreatic cysts Michelle Anderson

8:15 am • ASGE Postgraduate Course S100abBest Tips, Worst Mistakes: Lessons From the Masters, Day Two

Video cases, panel discussion, audience Q & A Amitabh Chak, Todd Baron, Nageshwar Reddy, Kenneth Binmoeller, Michelle Anderson, John Baillie

Monday, May 8, 2017

AGA Postgraduate Course ASGE Postgraduate Course

Poster Tours

11:45 AM – 12:30 PM South HallIBS Session – Poster TourWilliam Chey

Monday, May 8, 2017

11:45 AM E450bQuality improvement in endoscopyGrace Elta




Daily Schedule

8:00 – 9:30 AM • AGA Research Forum S105bcdMechanisms of host-mucosal response to injury and H. pylori infectionModerators: Mohamad El-Zaatari, Nicola Jones

8:00 – 9:30 AM • AGA Translational Symposium S102dMetabolic diseases of the liver in adultsModerators: Robert Fontana, Ronald Sokol

8:00 – 9:30 AM • AGA Research Symposium S102abcBasic science: Solving clinical conundrums in IBDModerators: Peter Higgins, Gerhard Rogler

8:00 – 9:30 AM • ASGE Clinical Symposium S401Small bowel challengesModerators: Michael Rice, Carol Semrad

8:00 – 9:30 AM • AGA Clinical Symposium S406bPost-ERCP pancreatitisModerators: Jacques Van Dam, Erik-Jan Wamsteker

8:00 AM • AGA Research Forum S405Current diagnoisis of IBS with diarrhea William Chey

8:00 AM • AGA Research Forum S104MAZ promotes colitis-associated colon tumorigenesis through regulation of STAT3 signaling Daniel Triner, Yatrik Shah

8:15 AM • AGA Research Forum S104Nuclear-to-cytosolic shuttling of the DNA mismatch repair protein MSH3 requires posttranslational modification and interacts with an inflammation-related cytosolic complex Stephanie Tseng-Rogenski, Koji Munakata, Supal Mehta, Mamoru Uemura, Tsunekazu Mizushima, Masaki Mori, Minoru Koi, John Carethers

8:30 AM • AGA Research Forum S406aValidation of a tool predicting complications on cross-sectional imaging among young inpatients with Crohn’s disease Jeffrey Berinstein, Jeremy Adler, Akbar Waljee, Ryan Stidham, Julajak Limsrivilai, Peter Higgins, Shail Govani

8:40 AM • AGA Clinical Symposium S100cHow can we impact clinical and research policy?John Allen

9:00 AM • AGA Clinical Symposium • Panel Discussion S100cGastroenterology in the Age of TrumpSpencer Dorn, Folasade (Fola) May, John Allen, F. Taylor Wootton, Michael Roberts, Kathleen Teixeira

9:00 AM • AGA Research Forum S105bcdDendritic cell–derived TGF-β mediates the induction of Helicobacter-specific regulatory T cell response essential for maintenance of immune tolerance in miceMin Zhang, Mohamad El-Zaatari, Kathryn Eaton, Helmut Grasberger, John Kao

9:15 AM • AGA Research Forum • State-of-the-Art Lecture S104Inflammatory signaling networks driving gastrointestinal carcinogenesisYatrik Shah

10:44 AM • AGA Clinical Symposium S100cFODMAPs diet – 10 years on and still ticking!William Chey

11:15 AM • AGA Research Forum S105aTranscription factor ZBP-89 cooperates with β-catenin in the Lgr5+ stem cellRamon Ocádiz-Ruiz, Michael Hayes, Juanita Merchant

11:30 AM – 2:00 AM • ASGE Hands-On Workshop South HallSuturing and ClosuresModerator: Juanita Merchant

11:45 AM • AGA Postgraduate Course Luncheon Breakout E253bHealth care advocacy and legislative changesJohn Allen

11:45 AM • AGA Postgraduate Course Luncheon Breakout E450bQuality Improvement in EndoscopyGrace Elta

1:25 PM • AGA Postgraduate Course Arie Crown TheaterThe Biliary Tree and Pancreas: The Full Scope of GI AdvancesChronic pancreatitisMatthew DiMagno

2:00 – 3:30 PM • ASGE Clinical Symposium S404ERCP optimizing cannulation and outcomes – Techniques and controversiesModerators: Michelle Anderson, David Jaffe

2:00 – 3:30 PM • AGA Clinical Symposium S406bChronic pancreatitis, diabetes and pancreatic cancer: NIH ConsortiumModerators: Darwin Conwell, Matthew DiMagno

2:00 – 3:30 PM • AGA Translational Symposium S102abcIntestinal Metaplasia in the Esophagus and Stomach:Highlights of the 2016 Freston ConferenceModerators: Robert Genta, Juanita Merchant

continued next page



Daily Schedule

6:30 – 7:45 AM • DDW Breakfast With the Expert S405STAT scope: Approach to endoscopic emergenciesMichelle Anderson, John Martin

8:00 – 9:30 PM • AGA Research Forum S100cIBD: Comparative effectiveness studiesModerators: Christina Ha, Ryan Stidham

8:00 AM • AGA Research Forum S103Prevalence and predictors of IBS-like symptoms in the United States: Results from a survey of over 71,000 AmericansChristopher Almario, William Chey, Brennan Spiegel

8:00 AM • ASGE Clinical Symposium S503GWC Symposium 2017: Leveling the Playing Field

Current gender and diversity inequities in gastroenterologyGrace H. Elta

9:00 AM • AGA Research Forum S103Tryptophan hydroxlase 1 (TPH1) promoter genotype but notserum serotonin levels identify IBS-D patients more likely to benefit from the low FODMAP dietShanti Eswaran, Juanita Merchant, Amanda Photenhauer, Kenya Jackson, Dennis Madriaga, Fabiyola Selvaraj, Fred Princen, William Chey

10:00 – 11:30 PM • AGA Research Symposium S101aFunderburg Symposium: 25 Years of Gastric Cancer ResearchModerators: C. Richard Boland, Juanita Merchant

10:06 AM • AGA Research Forum S106Recurrent acute pancreatitis without underlying overt chronic pancreatitis negatively impacts quality of lifeGregory Cote, Dhiraj Yadav, Judah Abberbock, Gong Tang, Adam Slivka, Randall Brand, Michelle Anderson, Peter Banks, Michele Lewis, John Baillie, Stuart Sherman, Samer Alkaade, Stephen Amann, Andres Gelrud, Chris Forsmark, Bimaljit Sandhu, Nalini Guda, Darwin Conwell, Thiruvengadam Muniraj, C. Mel Wilcox, David Whitcomb, Timothy Gardner

10:43 AM • AGA Research Symposium S101aFunderburg Symposium: 25 Years of Gastric Cancer Research

Notch pathway induction of gastric tumorigenesisLinda Samuelson

2:00 – 3:30 PM • AGA Clinical Symposium S501Beyond sporadic colorectal cancer and esophageal adenocarcinoma: Controversies in screening for the “other” GI cancersModerators: Loren Laine, Joel Rubinstein

continued next page

Sunday, May 7, 2017Saturday, May 6, 2017

2:00 – 3:30 PM • AGA Research Symposium S105aMechanisms of Mucosal RepairModerators: Yatrik Shah, Shanthi Srinivasan

2:15 PM • AGA Research Forum S105bcdClustering of esophageal cancer mortality among white men in the United StatesJoel Rubenstein

2:30 PM • AGA Research Forum S100abMachine learning models at week 6 of vedolizumab therapy for ulcerative colitis can accurately predict week 52 corticosteroid free endoscopic remissionAkbar Waljee, Boang Liu, Kay Sauder, Ji Zhu, Shail Govani, Ryan Stidham, Peter Higgins

4:00 – 5:30 PM • AGA Research Forum S403bEndoscopic qualityModerators: Megan Adams, Lukejohn Day

4:00 – 5:30 PM • AGA Research Forum S406aAdvances in diagnosis and treatment of IBSModerators: Shanti Eswaran, Lucinda Harris

4:00 – 5:30 PM • AGA Clinical Symposium S502Kristin & David Peura, MD, Lecture: Help! I can’t get rid of H. pyloriModerators: Emad El-Omar, John Kao

4:00 – 5:30 PM • AGA Clinical Symposium S105bcdLinking quality and reimbursement in IBDModerators: Ziad Gellad, Akbar Waljee

4:00 PM • AGA Research Forum S106Absent in melanoma 2 (AIM2) deficiency exacerbates pseudopyloric metaplasia during chronic Helicobacter infection, due to an accumulation of CD8+ T cells in the gastric mucosaMohamad El-Zaatari, Min Zhang, Nobuhiko Kamada, Shrinivas Bishu, Helmut Grasberger, John Kao

4:15 PM • AGA Clinical Symposium S502Kristin & David Peura, MD, Lecture: Help! I Can’t Get Rid of H. pyloriDiscussion 2: How to optimize treatment to achieve success with salvage therapy including role of H. pylori culture and sensitivityWilliam Chey

4:15 PM • AGA Research Forum S403bAppropriateness of surveillance interval in non-dysplastic Barrett’s esophagusAnna Tavakkoli, Chaitra Madiyal, Henry Appelman, Maryam Khodadost, Kimberly Nofz, Val Metko, Grace Elta, David Beer, Thomas Wang, Joel Rubenstein

5:15 PM • AGA Research Forum • State-of-the-Art Lecture S403bShould ADR be the one and only measure of colonoscopy quality?Sameer Saini


Daily Schedule

Sunday, May 7, 2017

7:45 AM • ASGE Postgraduate Course S100abBest Tips, Worst Mistakes: Lessons From the Masters, Day Two

Optimal strategies for managing incidental pancreatic cysts Michelle Anderson

8:00 – 9:30 AM • AGA Clinical Symposium S105aTaking back power: Options for organizing physicians to enhance bargaining powerModerators: Megan Adams, John Allen

8:00 AM • AGA Clinical Symposium S105aHistory of physicians organizing in the United StatesJohn Allen

8:12 AM • AGA Research Forum S100cAutonomic function in gastroparesis: Relationship with etiology, gastric emptying and symptom severityLinda Anh Nguyen, Laura Wilson, William Hasler, Pankaj Pasricha, William Snape, Henry Parkman, Irene Sarosiek, Richard McCallum, Kenneth Koch, Gianrico Farrugia, Madhusudan Grover, Braden Kuo, Laura Miriel, James Tonascia, Frank Hamilton, Thomas Abell

8:15 AM • ASGE Postgraduate Course S100abBest Tips, Worst Mistakes: Lessons From the Masters, Day Two

Video cases, panel discussion, audience Q & A Amitabh Chak, Todd Baron, Nageshwar Reddy, Kenneth Binmoeller, Michelle Anderson, John Baillie

8:18 AM • AGA Clinical Symposium S105aLegal considerations governing physician unionizationMegan Adams

8:24 AM • AGA Research Forum S100cRelationship of symptoms of gastroparesis to gastric pathophysiology Henry Parkman, Perry Orthey, Mark Van Natta, Alan Maurer, Daohai Yu, Frederick Ramsey, Jesus Diaz, Paige Clark, Andrei Iagaru, Roberto Fragomeni, William Hasler, Gianrico Farrugia, Kenneth Koch, Linda Anh Nguyen, William Snape, Thomas Abell, Richard McCallum, Irene Sarosiek, John Clarke, Laura Miriel, James Tonascia, Frank Hamilton, Pankaj Pasricha

8:36 AM • AGA Research Forum S100cReduction in symptoms during provocative meal testing with insulin pump therapy plus continuous glucose monitoring in patients with gastroparesis due to poorly controlled diabetes: Relation to gastric myoelectrical activity Kenneth Koch, William Hasler, Jorge Calles-Escandon, Mark Van Natta, William Snape, Pankaj Pasricha, Linda Anh Nguyen, Henry Parkman, Richard McCallum, Irene Sarosiek, Thomas Abell, Gianrico Farrugia, Madhusudan Grover, Frank Hamilton, James Tonascia, Linda Lee

continued next page

Monday, May 8, 2017

2:00 – 3:30 pm • AGA Distinguished Abstract Plenary S105aCellular and Molecular GastroenterologyModerators: Charalabos Pothoulakis, Linda Samuelson

2:00 pm • AGA Clinical Symposium E350Rodger C. Haggitt Gastrointestinal Pathology Society SymposiumGetting the Most Out of Your Pathologist: Three Illustrative Cases

A rash diagnosis of inflammatory bowel diseaseJohn Hart, Jami Kinnucan

2:06 PM • AGA Distinguished Abstract Plenary S105aCellular & Molecular Gastroenterology

Regulation of CD44 expression by bone morphogenetic protein (BMP) signaling and inflammatory stimuliWei Ye, Hidehiko Takabayashi, Yitian Yang, Maria Mao, Linda Samuelson, Elise Demitrack, Fung-yu Huang, Kent-Man Chu, Wai Leung, Andrea Todisco

4:00 PM – 5:30 PM • AGA Research Forum S403bUpper GI bleeding and appropriate use of PPIsModerators: David Armstrong, Jacob Kurlander

4:00 PM – 5:30 PM • AASLD Plenary Session S403aClinical PlenaryModerators: Kimberly Brown, Anna Lok

4:00 – 5:30 PM • AGA Plenary Session S102abcBasic Science PlenaryModerators: Linda Samuelson, Jerrold Turner

4:00 – 5:30 PM • AGA Distinguished Abstract Plenary S104Neurogastroenterology and MotilityModerators: Satish Rao, John Wiley

4:05 PM • AGA Committee Sponsored Symposium S102dAdding Value to Your Practice: Three Trends You Should Know

Evolving businees models of GI careJohn Allen

4:15 PM • AGA Research Forum S403bPoor adherence to recommendations to prevent gastrointestinal bleeding among anticoagulation clinic patientsJacob Kurlander, Xiaokui Gu, James Scheiman, Brian Haymart, Eva Kline-Rogers, Sameer Saini, Scott Kaatz, Steve Almany, Michael McNamara, Jay Kozlowski, James Froehlich, Geoffrey Barnes

5:05 PM • AGA Committee Sponsored Symposium • Panel Discussion S102dAdding Value to Your Practice: Three Trends You Should KnowJohn Allen, Ryan Madanick, Keisa Lynch

5:15 PM • AGA Research Forum S101bButyrate regulates transcription factor ZBP-89 and sustains proliferation under low glucose conditionsRamon Ocádiz-Ruiz, Michael Hayes, Juanita Merchant

9:00 AM • AGA Research Forum S503How cost affects the treatment choice for irritable bowel syndrome with diarrhea patients: A cost-effectiveness analysis of tricyclic agents and rifaximin Eric Shah, Elizabeth Andraska, Jonathan Li, Sai Zhang, William Chey

9:12 AM • AGA Clinical Symposium • Panel Discussion S105aTaking back power: Options for organizing physicians to enhance bargaining powerJohn Allen, Megan Adams, Fred Rosenberg, F. Taylor Wootton

9:12 AM • AGA Research Forum • State-of-the-Art Lecture S100cGastroparetic symptoms, symptom score and diagnostic tests – What do they tell and how useful? William Hasler

9:15 AM • AGA Research Forum S102dSoluble protein p40 produced by Lactobacillus rhamnosus GG enhances tight junction protein expression and improves epithelial integrity by preventing alteration of DNA methylation and histone acetylation in human colonoids Xu Han, Ji-Yao Li, Sha Huang, Jason Spence, Chung Owyang

10:00 – 11:00 AM • AASLD State-of-the-Art Lecture S405 DILI: Is this pill safe to swallow?Moderators: Robert Fontana, Folasade (Fola) May

10:00 – 11:30 AM • AGA Research Forum S100cOutcomes in IBDModerators: Gil Melmed, Akbar Waljee

10:30 AM • AGA Research Forum S100cDefining patient-centered outcomes for IBD and an international, cross-disciplinary consensus Andrew Kim, Charlotte Roberts, Brian Feagan, Rupa Banerjee, Willem Bemelman, Keith Bodger, Marc Derieppe, Axel Dignass, Richard Driscoll, Ray Fitzpatrick, Peter Higgins, Paulo Kotze, Jillian Meissner, Marian O’Connor, Zhihua Ran, Corey Siegel, Helen Terry, Welmoed van Deen, Christien Janneke Van Der Woude, Alandra Weaver, Suk-Kyun Yang, Bruce Sands, Severine Vermeire, Simon Traviss

10:45 AM • AGA Research Forum S501Clinical profile of early and late onset idiopathic chronic pancreatitis (ICP) and the influence of known genetic factors Michele Lewis, David Whitcomb, Jyothsna Talluri, Judah Abberbock, Andres Gelrud, Peter Banks, Timothy Gardner, Stephen Amann, Stuart Sherman, Bimaljit Sandhu, Samer Alkaade, Vikesh Singh, Darwin Conwell, Gregory Cote, Nalini Guda, Chris Forsmark, Charles Wilcox, Thiruvengadam Muniraj, Gong Tang, John Baillie, Randall Brand, Adam Slivka, Michelle Anderson, Dhiraj Yadav

Monday, May 8, 2017

Daily Schedule

Monday, May 8, 2017


10:45 AM • AGA Research Forum S403bMorphomics-based risk stratification model predicts complications after pancreaticoduodenectomy for pancreatic cystic neoplasmsAlexander K. Larson, Binu Enchakalody, Nicholas Wang, Diane M. Simeone, Hari Nathan, Clifford Cho, Stewart Wang, Grace Su, Richard Kwon

11:15 AM • AGA Research Forum • State-of-the-Art Lecture S100cBehavioral therapies as an adjunct for management of IBDMegan Riehl

11:29 AM • AGA Presidential Plenary S406Hepatitis B elimination: Is it possible?Anna Lok

11:45 AM – 12:30 PM • AGA Poster Tour South HallIBS SessionWilliam Chey

2:00 PM • AASLD State-of-the-Art Lecture S401Hepatitis B treatment: Current status and prospects for a cureAnna Lok

2:15 PM • AGA Research Forum S104Hedgehog pathway activation protects the colon during inflammatory colitisMichelle Muza-Moons, Audrey Urquhart, Deepa Chandhrasekhar, Deborah Gumucio

2:30 PM • ASGE Topic Forum S404Outcomes of multiple gateway versus single gateway transluminal endoscopic drainage and necrosectomy in patients with necrotizing pancreatitis and walled-off necrosis (WON) using lumen-apposing metal stents: results from an endoscopic step-up approach cohortTossapol Kerdsirichairat, Stuart Amateau, J. Shawn Mallery, Guru Trikudanathan, Rajeev Attam, Sidney Walker, Gregory Beilman, Martin Freeman, Mustafa Arain

2:30 PM • AGA Clinical Symposium S105aEarly onset colorectal cancer: What’s in your genes?Elena Stoffel

3:06 PM • AGA Clinical Symposium S105bcdManagement of low grade dysplasia: Surveillance or endoscopic therapy?Joel Rubenstein

continued next page



Daily Schedule

8:15 AM • ASGE Topic Forum S404Scoring system developed from an eight-year cohort of a consistent transluminal endoscopic step-up approach for walled-off necrosis (WON) to predict new onset diabetes mellitus (WON-DM score) in patients undergoing endoscopic intervention for walled-off necrosisTossapol Kerdsirichairat, Stuart K. Amateau, Sidney Walker, Mustafa A. Arain, Rajeev Attam, Gregory Beilman, Guru Trikudanathan, Martin L. Freeman

9:15 AM • AGA Committee Sponsored Symposium • Panel Discussion S102dTales from the front lines: How GI practices are using quality measurement to drive improvementZiad Gellad, Megan Adams, John Allen, James Leavitt, Fasiha Kanwal, Steven Carpenter, Corey Siegel

10:00 – 11:30 AM • AGA Research Forum E354aIBD: Controlled Clinical Trials Moderators: Peter Higgins, William Sandborn

10:00 – 11:30 AM • AGA Distinguished Abstract Plenary S502Clinical Practice Moderators: Paul Moayyedi, Joel Rubenstein

10:00 – 11:30 AM • AGA Research Forum S503H. pylori: Epidemiology, outcomes and treatmentModerators: Ernst Kuipers, Richard Saad

10:30 AM • AASLD Research Forum S405Antiviral therapy is under-utilized but associated with improved survival across tumor and liver disease stages and cancer therapies in HBV-related hepatocellular carcinoma (HCC): Results of a multicenter United States–Asia cohort of 2307 patientsVincent Chen, Ming-Lun Yeh, An Le, Peggy Tsai, Mijung Jun, Waqar Saeed, Hyo Young Lee, Pauline Nguyen, Nathan Kim, Chia-Yen Dai, Jee-Fu Huang, Chung-Feng Huang, Wan-Long Chuang, Dae Won Jun, Young-Suk Lim, Ming-Lun Yu, Mindie Nguyen

10:30 AM • AGA Research Symposium S105aMenin-MLL inhibitor MI-503 suppresses plasma gastrin in a mouse model of hypergastrinemia Sinju Sundaresan, Michael Hayes, Jolanta Grembecka, Juanita Merchant

10:45 AM • AASLD Research Forum S405Significantly lower rates of cirrhosis and lower long-term survival in cryptogenic hepatocellular carcinoma (HCC) compared to viral etiologies: Results of a multi-center international cohort Tomi Jun, Ju Dong Yang, Ming-Lun Yeh, Vincent Chen, Pauline Nguyen, Minh Chung, Nasra H. Giama, Chung-Feng Huang, Chia-Yeh Dai, Jee-Fu Huang, Wan-Long Chuang, Ming-Lun Yu, Lewis R. Roberts, Mindie H. Nguyen

continued next page


8:00 – 9:30 AM • AGA Committee Sponsored Symposium S102dTales from the front lines: How GI practices are using quality measurement to drive improvementModerators: Megan Adams, Ziad Gellad

8:00 – 9:30 AM • AGA Distinguished Abstract Plenary S104Esophageal, Gastric & Duodenal Disorders

The Best of Barrett’s, EOE, GERD, H. pyloriModerators: John Kao, Michael Vaezi

8:00 AM • AGA Committee Sponsored Symposium S102dTales from the front lines: How GI practices are using quality measurement to drive improvement

Setting the stage: The importance of quality measures in driving improvement in GIJohn Allen

Monday, May 8, 2017

4:00 PM • AGA Committee Sponsored Symposium S403bBest of AGA at DDW in Chinese

Inflammatory Bowel Disorders John Kao

4:15 PM • ASGE Clinical Symposium S401Special Situations in Endoscopy

Pregnancy (ERCP, sedation)Grace Elta

4:24 PM • AGA Research Forum S102dSerum 7C4 levels decrease after low FODMAP diet in IBS patients: A potential mechanism for benefitShanti Eswaran, Fabiyola Selvaraj, Fred Princen, Patty Tooker, Gulia Harvie, William Chey

4:54 PM • AGA Committee Sponsored Symposium S101aThe Road to Leadership in GIPrivate practice pioneers and how to be oneJohn Allen

5:12 PM • AGA Committee Sponsored Symposium S101aQuestions and AnswersThe Road to Leadership in GISheila Crowe, Kim Barrett, Michael Nathanson, John Allen


Daily Schedule


10:54 AM • AGA Research Forum S503Efficacy of high-dose dual therapy versus bismuth-containing quadruple therapy for first-line treatment of Helicobacter pylori infection and an interim report of multi-center, randomized control studyChi-Tan Hu, Chien-Chih Tung, Chun-Jung Lin, I-Nan Kuo, Bor-Ru Lin, Hong-Long Wang, Jin-De Chen, Mu-Liang Cheng, Chia-Tung Shun, Huei-Mi Li, Jui-Sheng Hung, Wei-Yi Lei, Ming Jium Shieh, Jau-Min Wong, John Kao, Jyh-Chin Yang

10:54 AM • ASGE Clinical Symposium E350Imaging: The Next Generation of Optical Diagnostics

In vivo molecular imaging Thomas Wang

11:00 AM • AGA Research Forum S101aBile acids regulate intestinal paneth cell functions and contribute to gut dysbiosis induced by high fat feeding Hui Zhou, Merritt Gillilland, Jun Gao, Shi-Yi Zhou, Guanpo Zhang, Chung Owyang

2:00 – 3:30 PM • AASLD Research Forum S403aHealth-Care in the Hospital and Clinic for Chronic Liver Disease Moderators: Kiran Bambha, John Magee

2:00 – 4:00 PM • DDW Clincal Symposium S100cThe Best of DDW 2017 Moderators: Steven Edmundowicz, Grace Elta

2:36 PM • AGA Research Forum S106Gastrointestinal motility and luminal pH influence in vivo dissolution and systemic absorption of drug product in human gastrointestinal tract under fed and fasted conditions Mark Koenigsknecht, Jason Baker, Ann F. Fioritto, Yasuhiro Tsume, Bo Wen, Joseph Dickens, Alex Yu, Jeffery Wysocki, Kerby Shedden, Barry Bleske,Allen Lee, William Hasler, Gordon Amidon, Duxin Sun

3:00 PM • AASLD Topic Forum S405Serum concentrations of cartilage oligomeric matrix protein are correlated with the presence of advanced hepatic fibrosis in untreated hepatitis C Ryan Stidham, Akbar Waljee, Peter Higgins, Anna Lok

3:00 PM • AGA Research Forum S102dChronic stress-associated abdominal pain: Glucocorticoid receptor mediates interleukin 6–induced down-regulation of epithelial tight junction protein occludin and enhanced visceral painYe Zong, Shengtao Zhu, John Wiley, Shuangsong Hong


3:15 PM • AASLD Research Forum S403aThey do hurt more: A nationwide study of falls and injury among patients with cirrhosisGhideon Ezaz, Elliot Tapper

4:00 PM • ASGE Clinical Symposium S402ASGE/Chinese Society of Gastroenterology (CSGE) International Symposium

Management of anti-thrombotics in elective and emergency endoscopy Michelle Anderson

5:00 PM • AGA Research Forum S101bPGE2 produced by mast cells is critical to induce visceral hypersensitivity in IBS Gintautas Grabauskas, Xiaoyin Wu, Kim Turgeon, Chung Owyang


Poster Sessions

Sa1016

The right idea in the wrong patient: A national survey of internists’ attitudes towards stopping PPIsJacob Kurlander, Mark Kolbe, Akbar Waljee, Brian Zikmund-Fisher, Sandeep Vijan, Arlene Weissman, James Scheiman, Joel Rubenstein, Sameer Saini

Sa1028

Patients are willing to repeat colonoscopy at a short interval when bowel preparation quality is suboptimalJennifer Maratt, Stacy Menees, Marc Piper, Brian Zikmund-Fisher, Sameer Saini

Sa1074

A simulation-based mastery learning model of percutaneous endoscopic gastrostomy tube placement improves gastroenterology fellow procedural attitudesAndrew Wright, Rafat Rizk, Anoop Prabhu

Sa1088

Training in small bowel endoscopy: Results of a national survey of GI fellowship programsAndrew Read, Michael Rice, Hari Conjeevaram, Sameer Saini

Sa1131

How is OIC diagnosed and managed? Insights from a virtual patient simulationJovana Lubarda, Martin Warters, Piyali Chatterjee, Brooks Cash, William Chey

Sa1241

High-fat feeding enhances stemness of intestinal progenitors and stimulates epithelial proliferation via upregulation of R-spondin 3 and its receptors LGR4 and 5Ji-Yao Li, Xiaoyin Wu, Merritt Gillilland, Shi-Yi Zhou, Chung Owyang

Sa1570

Liver injury in children undergoing treatment for cancer: Analysis of a large single-center cohort

Saturday, May 6, 2017 9:30 AM – 4:00 PM

Vanessa Cardenas, Nikhil Mankuzhy, Lili Zhao, Bailey Anderson, Kevin Frank, Maclovio Lopez, Robert Fontana, Rajen Mody, Frank DiPaola

Sa1618

Randomized controlled trial to assess the efficacy & safety of caraway oil/l-menthol plus usual care polypharmacy vs. placebo plus usual care polypharmacy for functional dyspepsiaWilliam Chey, Brian Lacy, Brooks Cash, Michael Epstein, Syed Shah

Sa1619

Efficacy of caraway oil/l-menthol plus usual care vs placebo plus usual care, in functional dyspepsia patients with post-prandial distress (PDS) or epigastric pain (EPS) syndromes: Results from a US RCTWilliam Chey, Brian Lacy, Brooks Cash, Michael Epstein, Syed Shah

Sa1620

A caraway oil/menthol combination improves functional dyspepsia (FD) symptoms within the first 24 hours: Results of a randomized controlled trial, which allowed usual FD treatmentsBrian Lacy, William Chey, Brooks Cash, Michael Epstein, Syed Shah

Sa1623

Sex differences in fecal incontinence: Results from a US population-based studyStacy Menees, Christopher Almario, Brennan Spiegel, William Chey

Sa1624

Clinical and economic impact of a multidisciplinary management program in patients with fecal incontinence: Do symptomatic improvements in fecal incontinence decrease personal costs?Stacy Menees, Kenya Jackson, Xiao Xu, Dee Fenner



Poster Sessions

Su1005

Location of healthcare delivery (county vs tertiary care based centers) may influence disease related outcomes in African-American patients with inflammatory bowel disease (IBD)Zachary Spiritos, Kevin Luk, Evan Brady, Amar Mandalia, Angela Ward, Saurabh Chawla, Heba Iskander, Tanvi Dhere

Su1035

Meta-analysis of missed high grade dysplasia or cancer in patients with Barrett’s esophagus diagnosed with low grade dysplasiaJoel Rubenstein, Akbar Waljee, Jacques Bergman, Michael Vieth, Sachin Wani

Su1278

Predictors of short-term and long-term resolution of symptomatic walled-off necrosis managed by endoscopic therapyTossapol Kerdsirichairat, Richard Kwon, Stuart Amateau, Sidney Walker, Mustafa Arain, J. Shawn Mallery, Rajeev Attam, Gregory Beilman, Guru Trikudanathan, Martin Freeman

Sunday, May 7, 2017 9:30 AM – 4:00 PM


Sa1638

A systematic review and meta-analysis to determine whether balloon expulsion testing might be an appropriate initial office-based test for dyssynergic defecationEric Shah, Jeremy Farida, William Chey

Sa1662

In ineffective esophageal motility, failed swallows are more functionally relevant than weak swallowsAnand Jain, Jason Baker, Joan Chen

Sa1813

MSI-L/EMAST, a poor outcome biomarker for colorectal cancer patients, is present in young ulcerative colitis patients that require high doses of anti-inflammatory agents, and shows clonalityKoji Munakata, Minoru Koi, Takahito Kitajima, Stephanie Tseng-Rogenski, Mamoru Uemura, Tsunekazu Mizushima, Yuji Toiyama, Masaki Mori, John Carethers

Sa1864

Intra-abdominal abscess size and the use of percutaneous drainage are not associated with avoidance of surgery in Crohn’s diseaseDaniel Perl, Shail Govani, Akbar Waljee, Peter Higgins, Ryan Stidham

Sa1946

Machine learning models at week 6 of vedolizumab therapy for inflammatory Crohn’s disease can accurately predict week 52 corticosteroid free biologic remissionAkbar Waljee, Boang Liu, Kay Sauder, Ji Zhu, Shail Govani, Ryan Stidham, Peter Higgins

Sa1950

Vedolizumab is safe and effective for IBD, but has no effect on liver biochemistry in patients with concurrent PSCBritt Christensen, Dejan Micic, Peter Gibson, Samrath Singh, Emanuelle Bellaguarda, Paul Corsello, John Gaetano, Jami Kinnucan, Vijaya Rao, Shilpa Reddy, Andres Yarur, David Rubin, Joel Pekow

Sa1953

Vedolizumab persistence and tolerability in special populations is similar to other IBD usersJoshua Turkeltaub, Akbar Waljee, Shail Govani, Julajak Limsrivilai, Peter Higgins, Ryan Stidham

Sa1997

Vitamin D deficiency in gastroparesis and chronic unexplained nausea and vomiting: Relationship with gastric emptying and symptomsPankaj Pasricha, Mark Van Natta, Richard McCallum, Linda Anh Nguyen, Irene Sarosiek, James Tonascia, Thomas Abell, William Hasler, Ellen Stein, John Clarke, Madhusudan Grover, Gianrico Farrugia, William Snape, Kenneth Koch, Frank Hamilton, Henry Parkman


Poster Sessions

Sunday, May 7, 2017 9:30 AM – 4:00 PM

Su1298

Plastic stents are comparable to lumen apposing metal stents in the management of pancreatic pseudocysts: a large international multicenter studyJuliana Yang, Yen-I Chen, Shai Friedland, Ian Holmes, Ryan Law, Amy Hosmer, Tyler Stevens, Matheus Franco, Sunguk Jang, Rishi Pawa, Nihar Mathur, Divyesh Sejpal, Sumant Inamdar, Arvind Trindade, Jose Nieto, Tyler Berzin, Michael DeSimone, Christopher DiMaio, Sanchit Gupta, Patrick Yachimski, Andrea Anderloni, Todd Baron, Theodore James, Laith Jamil, Mel Ona, Nuha Alammar, Eugenie Shieh, Majidah Bukhari, Olaya Isabella Brewer Gutierrez, Omid Sanaei, Lea Fayad, Saowonee Ngamruengphong, Vivek Kumbhari, Vikesh Singh, Alessandro Repici, Mouen Khashab

Su1394

Prevalence of pre-operative hyperbilirubinemia and predictors of choledocholithiasis in patients with acute calculus cholecystitisPhillip Chisholm, Arpan Patel, Shail Govani, Anoop Prabhu

Su1521

Symptom and anorectal manometry characteristics of constipated patients with fibromyalgiaJason Baker, Richard Saad, Stacy Menees, Shanti Eswaran, Allen Lee, William Chey, Borko Nojkov

Su1532

Indirect treatment comparison: Placebo-adjusted results from phase 3 trials of two GC-C agonists in patients with chronic idiopathic constipation – linaclotide and plecanatidePhillip Schoenfeld, An-Chen Fu, Courtney Walls, David Reasner, Kenneth Tripp, Robyn Carson, Jessica Abel, Douglas Taylor

Su1539

Impact of age and gender to severity of constipation-related symptoms and quality of life indices in patients with chronic idiopathic constipationBorko Nojkov, Jason Baker, Allen Lee, Shanti Eswaran, Stacy Menees, Richard Saad, William Chey

Su1548

Intragastric meal distribution (IMD) during routine gastric emptying scintigraphy (GES) to better relate symptoms of gastroparesis to abnormal gastric motilityPerry Orthey, Mark Van Natta, Alan Maurer, Daohai Yu, Frederick Ramsey, Jesus Diaz, Paige Clark, Andrei Iagaru, William Hasler, Gianrico Farrugia, Kenneth Koch, Linda Anh Nguyen, William Snape, Thomas Abell, Richard McCallum, Irene Sarosiek, John Clarke, Laura Miriel, James Tonascia, Frank Hamilton, Pankaj Pasricha, Henry Parkman

Su1550

Differences between obese and non-obese patients with idiopathic gastroparesisHenry Parkman, Erin Hallinan, William Hasler, Gianrico Farrugia, Kenneth Koch, Linda Anh Nguyen, William Snape, Thomas Abell, Richard McCallum, Irene Sarosiek, Laura Miriel, James Tonascia, Frank Hamilton, Pankaj Pasricha

Su1554

Relation of opiate use to clinical manifestations, quality of life, and resource use in gastroparesis: Impact of μ-opioid agonist potencyWilliam Hasler, Laura Wilson, Linda Anh Nguyen, William Snape, Henry Parkman, Thomas Abell, Kenneth Koch, Richard McCallum, Pankaj Pasricha, Irene Sarosiek, Gianrico Farrugia, Madhusudan Grover, Linda Lee, Laura Miriel, James Tonascia, Frank Hamilton

Su1573

Patients are uncomfortable with the use of risk calculators to guide decisions about colorectal cancer screening: Results of a large regional surveyMarc Piper, Jennifer Maratt, Anna Tavakkoli, Valbona Metko, Akbar Waljee, Brian Zikmund-Fisher, Sameer Saini

Su1574

Understanding why older patients continue low-value colorectal cancer screening: A systematic review of quantitative, qualitative, and mixed-methods studiesMarc Piper, Jennifer Maratt, Akbar Waljee, Carmen Lewis, Sameer Saini

Poster Sessions

Monday, May 8, 2017 9:30 AM – 4:00 PM


Sunday, May 7, 2017 9:30 AM – 4:00 PM

Su1771

Prevalence of germline mutations in individuals with multiple colon polypsShreya Sengupta, Kelly Watkins, Erika Koeppe, Monica Marvin, Elena Stoffel

Su1775

A minority of patients with colorectal cancer (CRC) are appropriately screened for Lynch syndrome in a dual center study of two large academically affiliated Veterans Affairs Medical Centers (VAMCs)Chetan Mittal, Duyen Dang, Anna Dang, Elena Stoffel, Dennis Ahnen, Swati Patel

Su1884

Autoimmune paradoxical reactions in inflammatory bowel diseases longitudinal (APRIL) cohort: Methodology and initial resultsMillie Long, Raymond Cross, Sumona Saha, Anita Afzali,Peter Higgins, Christopher Martin, Hans Herfarth

Su1925

Long-term safety and tolerability of oral tofacitinib in patients with Crohn’s disease: Results from a phase 2 open-label 48-week extension studyJulian Panés, Geert D’Haens, Peter Higgins, Linda Mele, Michele Moscariello, Gary Chan, Wenjin Wang, Wojciech Niezychowski, Chinyu Su, Eric Maller

Su1943

Gastrointestinal infectious agents detected by BioFire FilmArray GI PCR Panel stool testing in active inflammatory bowel disease are common and are associated with a more benign course of IBDJulajak Limsrivilai, Ryan Stidham, Akbar Waljee, Shail Govani, Krishna Rao, Brian Gutermuth, Alexandra Brown, Emily Briggs, Peter Higgins

Su1994

Probiotic-mediated protection against chronic water-avoidance stress enteritis in mice is associated with lamina propria plasmacytoid dendritic cell infiltrationChun-Chia Chen, Bryan Chow, Yundong Sun, Min Zhang, Mohamad El-Zaatari, Helmut Grasberger, John Kao

Mo1140

MiR-143-3p induced by Helicobacter infection inhibits TGF-β expression and mediates inflammatory dendritic cell phenotypeJiping Zeng, Lixiang Wang, Min Zhang, Mohamad El-Zaatari, Helmut Grasberger, John Kao

Mo1240

Lumen apposing stents are superior to plastic stents in the management of pancreatic walled-off necrosis: A large international multicenter studyYen-I Chen, Juliana Yang, Shai Friedland, Ian Holmes, Ryan Law, Amy Hosmer, Tyler Stevens, Matheus Franco, Sunguk Jang, Rishi Pawa, Nihar Mathur, Divyesh Sejpal, Sumant Inamdar, Arvind Trindade, Jose Nieto, Tyler Berzin, Michael DeSimone, Christopher DiMaio, Sanchit Gupta, Patrick Yachimski, Andrea Anderloni, Todd Baron, Theodore James, Laith Jamil, Mel Ona, Nuha Alammar, Eugenie Shieh, Majidah Bukhari, Olaya Isabella Brewer Gutierrez, Omid Sanaei, Lea Fayad, Dongxun Zhou, Saowonee Ngamruengphong, Vivek Kumbhari, Vikesh Singh, Alessandro Repici, Mouen Khashab

Mo1314

Patient and disease characteristics associated with presence of diabetes mellitus in adults with chronic pancreatitis in the U.S.Melena Bellin, David Whitcomb, Judah Abberbock, Stuart Sherman, Bimaljit Sandhu, Timothy Gardner, Michelle Anderson, Michele Lewis, Samer Alkaade, Vikesh Singh, John Baillie, Peter Banks, Darwin Conwell, Gregory Cote, Nalini Guda, Thiruvengadam Muniraj, Gong Tang, Randall Brand, Andres Gelrud, Stephen Amann, Chris Forsmark, C. Mel Wilcox, Adam Slivka, Dhiraj Yadav

Mo1479

Elevated intrabolus pressure (IBP) as a marker of structural esophagogastric junction (EGJ) processes when integrated relaxation pressure (IRP) is normal on esophageal high resolution manometry (HRM): A validation studyFarhan Quader, Chanakyaram Reddy, Amit Patel, C. Prakash Gyawali

Tuesday, May 9, 2017 9:30 AM – 4:00 PM


Poster Sessions

Mo1545

Patients with IBS-C report more severe, bothersome, frequent and diffuse abdominal pain vs. IBS-D: Results of a nationwide population-based studyEric Shah, Christopher Almario, Brennan Spiegel, William Chey

Mo1546

Assessing long-term persistence with pharmacotherapy for constipation-predominant irritable bowel syndrome and functional constipation in clinical practice: A retrospective cohort analysisEric Shah, William Chey, Ryan Stidham

Mo1562

The low FODMAP diet is equally efficacious in IBS-D patients with and without baseline anxiety: A post-hoc analysis from a US randomized, controlled trialShanti Eswaran, William Chey, Kenya Jackson, Theresa Han-Markey

Mo1666

Differences in demographic and symptom-related characteristics among patients with irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC): Results from the CONTOR StudyJessica Abel, Douglas Taylor, Jalpa Doshi, Carolyn Martin, Alyssa Goolsby Hunter, Breanna Essoi, Paul Buzinec, Robyn Carson, David Reasner, William Chey

Mo1718

The systemic inflammatory response to Clostridium difficile infection (CDI) in patients with ulcerative colitisJulajak Limsrivilai, Krishna Rao, Ryan Stidham, Shail Govani, Akbar Waljee, Andrew Reinink, Laura Johnson, Emily Briggs, Peter Higgins

Mo1792

IBD patients with severe disease are at greater risk of developing pneumonia prior to IBD diagnosisMartin Gregory, Matthew Ciorba, Wyndy Wiitala, Ryan Stidham, Peter Higgins, Jason Hou, Linda Feagins, Shail Govani, Akbar Waljee

Mo1862

Targeted loss of forkhead box A1 (FOXA1) transcription factor sites within the hypoxia inducible factor 3A (HIF3A) locus from liver metastasis (LM) derived from MSI-L/EMAST primary colorectal cancer (CRC)Alexander W. Worix, Minoru Koi, Takahito Kitajima, Chan Choi, Hyeong-Rok Kim, Yuji Toiyama, Masato Kusunoki, John Carethers

Monday, May 8, 2017 9:30 AM – 4:00 PM Monday, May 8, 2017 9:30 AM – 4:00 PM

Tu1063

Despite high interest in telemedicine video visits for maintenance IBD care, few patients are willing to pay more for increased convenienceJack Bevins, Shail Govani, Akbar Waljee, Peter Higgins, Ryan Stidham

Tu1119

Systematic review and meta-regressions: Management of eosinophilic esophagitis requires histologic assessmentJoy Chang, Raymond Yeow, Akbar Waljee, Joel Rubenstein

Tu1415

An international multicenter study on digital single operator cholangioscopy for the management of difficult bile duct stones in 271 patientsOlaya Isabella Brewer Gutierrez, Saowonee Ngamruengphong, Isaac Raijman, Richard Sturgess, Divyesh Sejpal, Stuart Sherman, Raj Shah, Richard Kwon, James Buxbaum, Claudio Zulli, Wahid Wassef, Douglas Adler, Daniel Mullady, Andrew Wang, Kumar Krishnan, Vivek Kaul, Demetrios Tzimas, Christopher DiMaio, Sammy Ho, Bret Petersen, George Webster, Moon Sung Lee, Yen-I Chen, Laura Dwyer, Sumant Inamdar, Sheryl Lynch, Augustin Attwell, Amy Hosmer, Amar Manvar, Christopher Ko, Attilio Maurano , Avik Sarkar, Linda Taylor, Vladimir Kushnir, Jessica Harris, Sanchit Gupta, John Martin, Noor Bekkali, Yun Nah Lee, Daniel Strand, Ali Raza,


Poster Sessions

Tuesday, May 9, 2017 9:30 AM – 4:00 PM

Majidah Bukhari, Omid Sanaei, Shivangi Kothari, Martin Gregory, Asad Ullah, Truptesh Kothari, Christopher Gostout, Mark Topazian, Dushant Uppal, Arvind Trindade, Juan Carlos Bucobo, Nikhil Kumta, Vanessa Patrick, Mouen Khashab

Tu1499

Use of a double-pigtail stent to prevent migration of fully covered metal stents in biliary strictures: A retrospective analysisArpan Patel, Phillip Chisholm, Ryan Law, Erik-Jan Wamsteker, Grace Elta, Richard Kwon, Anoop Prabhu, James Scheiman, Michelle Anderson

Tu1520

Access to care and cirrhosis outcomes: A nationwide analysis of the Truven MarketScan employer-sponsored insurance databaseJessica Mellinger, Kerby Shedden, Elliot Tapper, Anna Lok, Michael Volk

Tu1554

Prevalence and new starts of proton pump inhibitors (PPI) in patients presenting with variceal bleeding: A 5 year, multi-center US experienceElliot Tapper, Jennifer Friderici, Zachary Borman, Jacob Alexander, Alan Bonder, Sheryl Ramdass, Rony Ghaoui

Tu1655

Gastrin stimulates nuclear export of menin and proteasomal degradation in enteric glial cellsSinju Sundaresan, Michael Hayes, Lin Ding, Juanita Merchant

Tu1664

Gastric emptying and symptoms of gastroparesis: Specific symptoms correlating to severity of gastric retentionHenry Parkman, Katherine Yates, Alan Maurer, William Hasler, Gianrico Farrugia, Madhusudan Grover, Kenneth Koch, Linda Anh Nguyen, William Snape, Thomas Abell, Richard McCallum, Irene Sarosiek, James Tonascia, Pankaj Pasricha, Frank Hamilton

Tu1872 • Poster of Distinction

Inhibition of Axl signaling by BGB324 reduces fibrogenesis in human intestinal cells and human intestinal organoidsCalen Steiner, Eva Rodansky, Laura Johnson, Sha Huang, Jason Spence, Peter Higgins

Tu1874

Use of second harmonic generation (SHG) and 2-photon emission imaging to quantify and describe the structure of tissue fibrosis in the rat TNBS intestinal fibrosis modelLaura Johnson, David Moons, Li Chen, Mathieu Petitjean, Peter Higgins, Ryan Stidham

Tu1962

Novel peptide probe targets GPC3 overexpression in vivo in hepatocellular carcinomaQuan Zhou, Zhao Li, Juan Zhou, Xiyu Duan, Rork Kuick, Thomas Wang

Tu1995

Claudin-1 and ErbB2 are potential biomarkers for biliary intraepithelial neoplasia, a premalignant precursor of cholangiocarcinomaMatthew Sturm, Bishnu Joshi, Scott Owens, Thomas Wang

Tu2011

Transcutaneous shear wave elastography ultrasound can measure longitudinally worsening intestinal fibrosis in a rat model of Crohn’s diseasePeter Higgins, Laura Johnson, Porzondek Kelli, Jonathan Rubin, Jonathan Dillman

Tu2031

Targeted delivery of linaclotide to specific areas of the intestine affects clinical efficacy in patients with irritable bowel syndrome with constipation (IBS-C)William Chey, Paul Chamberlin, Wiesław Bochenek, Kenneth Tripp, Carolyn Higgins, Nicholas Omniewski, Susan Fox, Michael Hall, Ahmad Hashash, Matthew Miller, Christopher O’Dea, Mark Currie


Faculty

Index

Fellows

Page

ADAMS, Megan ......................................................................9, 10, 16, 19, 20, 21, 22

ALLEN, John ................................................................... 10, 15, 16, 17, 18, 20, 21, 22

ANDERSON, Michelle .............................12, 13, 16, 17, 18, 19, 20, 21, 23, 27, 29

BISHU, Shrinivas .................................................................................................6, 11, 19

CARETHERS, John ........................................................................... 1, 3, 11, 18, 25, 28

CHEN, Joan ...................................................................................................................... 25

CHEY, Bill ................................11, 12, 13, 15, 17, 18, 19, 21, 22, 24, 25, 26, 28, 29

CONJEEVARAM, Hari ........................................................................................... 1, 4, 24

DANG, Duyen ................................................................................................................. 27

DiMAGNO, Matt ..................................................................................................9, 17, 18

ELTA, Grace ...................................................1, 10, 11, 15, 16, 17, 18, 19, 22, 23, 29

EL-ZAATARI, Mo ....................................................................................9, 11, 18, 19, 27

ESWARAN, Shanti ..................................................................9, 12, 13, 19, 22, 26, 28

FONTANA, Bob......................................................................................9, 10, 18, 21, 24

GILLILLAND, Merritt ....................................................................................... 14, 23, 24

GOVANI, Shail ...................................................................... 11, 18, 19, 25, 26, 27, 28

GRABAUSKAS, Gintas ........................................................................................... 14, 23

GUMUCIO, Deb ....................................................................................................... 13, 21

HASLER, Bill ..............................................................12, 13, 14, 20, 21, 23, 25, 26, 29

HIGGINS, Peter ....................... 9, 10, 11, 13, 14, 18, 19, 21, 22, 23, 25, 27, 28, 29

HOSMER, Amy .................................................................................................. 26, 27, 28

HONG, Shuangsong ............................................................................................. 14, 23

KAMADA, Nobu ...................................................................................................... 11, 19

KAO, John ........................................................1, 9, 10, 11, 14, 16, 18, 19, 22, 23, 27

KINNUCAN, Jami ............................................................................................. 15, 20, 25

KOI, Minoru ................................................................................................ 11, 18, 25, 28

KURLANDER, Jacob ................................................................................. 10, 12, 20, 24

KWON, Richard ......................................................................................... 13, 21, 25, 28

LAW, Ryan ......................................................................................................6, 26, 27, 29

LEE, Allen ........................................................................................................... 14, 23, 26

LI, Ji-Yao .............................................................................................................. 13, 21, 24

LOK, Anna ..........................................................................8, 10, 13, 14, 20, 21, 23, 29

MAGEE, John ........................................................................................................... 10, 23

MELLINGER, Jessica ...................................................................................................... 29

MENEES, Stacy ........................................................................................................ 24, 26

MERCHANT, Juanita ................................1, 5, 9, 10, 11, 12, 16, 18, 19, 20, 22, 29

MUZA-MOONS, Michelle .................................................................................... 13, 21

NOJKOV, Borko .............................................................................................................. 26

OMARY, Bishr .......................................................................................................................

OWYANG, Chung .............................................................................. 13, 14, 21, 23, 24

PRABHU, Anoop .............................................................................................. 24, 26, 29

READ, Andrew ................................................................................................................ 24

RICE, Michael .......................................................................................................9, 18, 24

Page

CHANG, Joy ..................................................................................................................... 28

CHEN, Vincent ......................................................................................................... 14, 22

CHISHOLM, Phillip ................................................................................................. 26, 29

CORSELLO, Paul ............................................................................................................. 25

JAIN, Anand .................................................................................................................... 25

KERDSIRICHAIRAT, Tos .................................................................6, 13, 14, 21, 22, 25

MANDALIA, Amar ......................................................................................................... 25

MARATT, Jennifer ................................................................................................... 24, 26

PATEL, Arpan ........................................................................................................... 26, 29

PIPER, Marc .............................................................................................................. 24, 26

REDDY, Shan ................................................................................................................... 27

SENGUPTA, Shreya ....................................................................................................... 27

SHAH, Eric ................................................................................................... 12, 21, 25, 28

STURM, Matthew .......................................................................................................... 29

TAVAKKOLI, Anna ............................................................................................ 11, 19, 26

WRIGHT, Andrew .......................................................................................................... 24

Faculty Page

RIEHL, Megan .......................................................................................................... 13, 21

RIZK, Rafat ....................................................................................................................... 24

RUBENSTEIN, Joel .............................................1, 10, 11, 16, 19, 21, 22, 24, 25, 28

SAAD, Rick ......................................................................................................... 10, 22, 26

SAINI, Sameer.............................................................................. 11, 12, 19, 20, 24, 26

SAMUELSON, Linda........................................................................ 1, 8, 10, 15, 19, 20

SCHEIMAN, Jim ......................................................................................... 12, 20, 24, 29

SCHOENFELD, Phil ........................................................................................................ 26

SHAH, Yatrik ..................................................................................................9, 11, 18, 19

SPENCE, Jason.................................................................................................. 13, 21, 29

STIDHAM, Ryan ...............................................10, 11, 14, 18, 19, 23, 25, 27, 28, 29

STOFFEL, Elena ................................................................................................ 16, 21, 27

SU, Grace ................................................................................................................... 13, 21

TAPPER, Elliot ................................................................................................... 14, 23, 29

TODISCO, Andrea ......................................................................................................8, 20

TSENG-ROGENSKI, Stephanie .................................................................... 11, 18, 25

TURGEON, Kim ........................................................................................................ 14, 23

VOLK, Michael ................................................................................................................ 29

WALJEE, Akbar ..............................9, 10, 11, 14, 18, 19, 21, 23, 24, 25, 26, 27, 28

WAMSTEKER, Erik-Jan .......................................................................................9, 18, 29

WANG, Tom ......................................................................................... 11, 16, 19, 23, 29

WILEY, John ............................................................................................1, 10, 14, 20, 23

ZHOU, Juan ..................................................................................................................... 29

ZHOU, Shi-Yi ..................................................................................................... 14, 23, 24

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