soft i gen 767 prod info

Product Information 06.05

SOFTIGEN® 767

Sasol Germany GmbH Oleochemicals Arthur-Imhausen-Str. 92, 58453 Witten, Germany 1/6 Phone: +49 2302 925-251 Fax: +49 2302 925-358 [email protected] www.sasol.com

1. Description SOFTIGEN 767 is a surface active, water soluble clear liquid which serves as refatting and solubilizing agent in cosmetic and pharmaceutical formulations. SOFTIGEN 767 is the oxethylation product of medium chain partial glycerides whose fatty acids are derived from coconut- and palmkernel oil.

2. INCI/CTFA name: PEG-6-Caprylic/Capric Glycerides 3. JCIC* (Japan) PEG-6-Caprylic/Capric/Glycerides 4. Ph.Eur. 2000 Macrogol 6 Glycerol Caprylocaprate Characteristic values

Tests Value Unit Method Acid value max. 1 mg KOH/g Ph.Eur. 2.5.1

Saponification value 90 – 100 mg KOH/g DGF C-V3

Iodine value max. 1.0 g I2/100 ml DGF C-V 11b

Color max. 150 APHA ISO 6271

Water max. 0.5 % Ph.Eur. 2.5.12

Dioxane max. 1 ppm GC

Free ethylene oxide max. 1 ppm GC

Alkaline reacting substances max. 0.5 ml Ph.Eur. 2.4.19

Hydroxyl value 165 – 225 mg KOH/g DGF C-V 17A

Ash max. 0.3 % DGF M-V 4

Fatty acid C6 max. 2.0 % GC

Fatty acid C8 50.0 - 80.0 % GC

Fatty acid C10 20.0 - 50.0 % GC




SOFTIGEN® 767


5. Properties SOFTIGEN 767 is a viscous (approx. 160 mPa.s), slightly yellow liquid with a neutral odour. The density is 1.08 g/cm³ at 20 °C. SOFTIGEN 767 acts as an emollient with good skin toleration and its skin toleration, even on eczematous skin, is exceptional. SOFTIGEN 767 imparts a long-lasting pleasant skin feel, even in „rinse-off products“ because it becomes water-insoluble at high dilutions. Because of its high solubilisation ability for amphiphilic pharmaceutical active ingredients and its shorter fatty acid chain lengths SOFTIGEN 767 is able to increase bioavailability on the skin or mucosa. SOFTIGEN 767 is free of preservatives, solvents and other additives. Because of special purification processes the amount of monomere residues is extremely low. SOFTIGEN 767 is stable and can therefore be easily stored. During processing in aqueous systems, no hydrolysis occurs, even after heating. Viscosity of SOFTIGEN 767 Viscosity of aquaeous SOFTIGEN in relation to temperature 767 mixtures


SOFTIGEN® 767


6. Miscibilities of several solvents with SOFTIGEN 767 Solvents SOFTIGEN 767 ethanol 96 % clearly miscible in every ratio isopropanol clearly miscible in every ratio ethylbutylacetate clearly miscible in every ratio glycerol miscible up to max. 90 % almond oil hardly soluble castor oil clearly miscible in every ratio mineral oil hardly soluble water from 0.1 to 0.8 % turbid then clearly miscible in every ratio. With rising temperature the clear solubility decreases.

7. Proof of the liquefying effect of SOFTIGEN 767 on surfactant blends

* Viscosity measured with Brookfield-Viscosimeter

* INCI/CTFA-name: Cocamidopropyl Betaine, 30 %

* INCI/CTFA-name: Sodium Laureth Sulphate, 28 %

8. Critical Micelle Concentration (CMC): The critical micelle concentration for SOFTIGEN 767 at 23 °C is: 6.0 x 10-3 mol/l.

9. Applications SOFTIGEN 767 because of its chemical, physical and physiological properties, is recommended as a refatting agent in cosmetic and pharmaceutical preparations. It improves the pliance of the skin preserving its lipid content, especially after cleansing, which causes defatting of the skin. In aqueous alcoholic formulations, such as after-shaves or pharmaceutical gels SOFTIGEN 767 is able to prevent skin contraction. With a calculated HLB value of approx. 19, SOFTIGEN 767 is able to solubilize fragrances, essential oils and volatile crystalline substances as well as certain active drug substances.

Surfactant blends comprising 30% AMPHOLYT JB 130K* and 30% MARLINAT 242/28* in water

SOFTIGEN 767-amount (%) 0 1 3 5 10

Viskosity in mPa.s at 20 °C 19.500 6.000 310 200 110


SOFTIGEN® 767


In the dermatological area SOFTIGEN 767 is used in the treatment of psoriatic deseases. It softens unpleasant scaling of the skin, it improves the effect of pharmaceuicals. Because of its water solubility SOFTIGEN 767 is a suitable adjuvant for treatment of deseases of the hairy parts of the scalp. In numerous formulations, especially of those containing surfactants SOFTIGEN 767 decreases viscosity. Therefore higher amounts of detergents can be used in liquid preparations (see above figure).

10. Toxicological data Oral toxicity LD50 (mouse/rat): > 5 g/kg body weight (practically not toxic). Draize-Skin test: SOFTIGEN 767 pure and 1% aqueous solution: Not irritant. Draize-Eye test: SOFTIGEN 767 pure: Acute irritations, 1% aqueous solution: Not irritant. Human Patch test: no primary toxic or primary allegic reactions. No sensitizing effect.

11. Delivery Plastic containers of 25 kg net. Steel drums of 200 kg net and Schütz containers of 1000 kg net.

12. Handling and storage Store in tightly-closed containers, below 25 °C, protected from light and moisture. Under these conditions the shelf life is at least three years.

13. Application examples Cosmetic Oil Foam Bath % A. MARLINAT 242/28 (Sodium Laureth Sulphate) 28,0 AMPHOLYT JB 130 (Cocamidopropyl Betaine) 7,0 SERDOLAMIDE PPF 67 (Cocamide DEA) 8,0 B. SOFTIGEN 767 (PEG-6 Caprylic/Capric Glycerides) 37,0 MIGLYOL 840 (Propylene Glycol Dicaprylate/Dicaprate) 20,0 Color q.s. Fragrance q.s. Preparation A is mixed, heated to approx. 75 °C cooled while stirring to about 30 °C. Then B is subsequently added.


SOFTIGEN® 767


Mild Foam Bath % A. MARLINAT CM 105/80 (Sodium Laureth-11 Carboxylate) 15,0 AMPHOLYT JB 130 (Cocamidopropyl Betaine) 25,0 SOFTIGEN 767 (PEG-6 Caprylic/Capric Glycerides) 5,0 Elfacos GT 282 S 1) (Hydrogenated Talloweth-60 Myristyl Glycol) 7,0 Color q.s. Preservative q.s. Water ad 100,0 B. Fragrance q.s. Preparation A is mixed and heated to approx. 75 °C. Cool down to about 30 °C. Then B is gradually added. Hair Fixative % A. SOFTIGEN 767 (PEG-6 Caprylic/Capric Glycerides) 1,5 Luviskol VA 64 2) (PVA-VA Copolymer) 2,0 Isopropanol or Ethyl Alcohol 38,0 Lactic acid 1,0 Fragrance q.s. Water ad 100,0 Preparation All ingredients are mixed and stirred until homogeneous.


SOFTIGEN® 767


After Shave % A. SOFTIGEN 767 (PEG-6 Caprylic/Capric Glycerides) 3,0 Ethyl Alcohol, 55 % 94,0 Glycerin 1,7 Locron L 3) (Al-Hydroxid-Chlorid) 0,4 Citric Acid 0,2 Menthol 0,2 Color 0,5 Fragrance q.s. Preparation All ingredients are mixed and stirred until a clear solution is obtained. Pharmacy Heparin gel % A. Heparin sodium 50.000,0 l.E. SOFTIGEN 767 (PEG-6 Caprylic/Capric Glycerides) 10,0 Carbopol 980 4) (Carbomer) 1,5 NaOH-solution 10 % 4,0 Preservative q.s. Water ad 100,0 Preparation Dissolve the heparin sodium in the quantitive of water specified, add the preservative. After weighing the quantity, add the Carbopol and NaOH solution and stir well, until a homogeneous gel is obtained. Gradually mix the gel with the SOFTIGEN.

14. List of suppliers 1) Registered trademark of AKZO Company, Amsterdam; 2) Registered trademark of BASF, Ludwigshafen

3) Registered trademark of Hoechst AG, Frankfurt; 4) Registered trademark of BF Goodrich, Cleveland

We reserve the right to make any changes according to technological progress or further developments. The customer is not released from the obligations to conduct careful inspection and testing of incoming goods. Reference to trade names used by other companies is neither a recommendation, nor is it intended or suggested that similar products could not be used. All our business transactions shall be governed exclusively by our General Sales Conditions of SASOL Germany GmbH.

soft i gen 767 prod info

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