Research News for the College of Veterinary Medicine February 2011

News: o Drs. Buffington and Lord study feature in the Columbus Dispatch o Dr. Jim Belknap and Dr. Aradhya Gourapura receive CCTS Pilot grants o Dr. Rosol to represent AVMA as liaison to the American Registry of Pathology o OSU Policy on Conflict of Interest – Office of Academic Affairs

Commercialization and Licensing Update: Dr. Jean Schelhorn and Laboratory Notebooks!

CVM Council for Research Update Vet Student Summer Program Update Selected Recent Grant Awards & Publications Upcoming Seminars and Workshops Grant Support Office Update:

o Grantwriting workshop for faculty and staff February 10, 2011 o 13th Annual OSUCCC Scientific Meeting February 18, 2011 o CCTS Annual Scientific Meeting March 4, 2011 o Funding Opportunities o What You Need to Know

FELINE STRESS STUDY FEATURED IN THE COLUMBUS DISPATCH

Drs. Tony Buffington (Professor, Veterinary Clinical Sciences) and Linda Lord (Assistant Professor, Veterinary Preventive Medicine) were featured in the January 11, 2011 issue of the Columbus Dispatch regarding their recent publication study of how stress in cats exacerbates feline urologic syndrome, FUS. The

study found that by providing an enriched environment for their cats, including a consistent routine, hiding areas, bedding and other physical features, cats afflicted with FUS exhibited significantly fewer symptoms manifested as less vomiting, voiding outside of the litter box, and anorexia. These are the types of symptoms and behaviors that can prompt owners to have the cats euthanized. The study is published in the Jan. 1, 2011, issue of the Journal of the American Veterinary Medical Association.

Dr. Belknap Utilizes CCTS Pilot Grant to Study Equine Laminitis

Dr. Jim Belknap, Associate Professor in Veterinary Clinical Sciences receives CCTS Pilot grant for Laser Capture Microdissection in Equine Laminitis. The project involves the use of Laser Capture Microdissection (LCM) to determine what cell signaling events in the equine foot prompt the disease to occur. LCM allows the investigator to isolate pure cell populations, single cells or even subcellular fragments for genetic or proteomic profiling. Dr. Belknap’s team will interrogate laminar epithelial cells isolated from the equine foot to gain insight into cell signaling mechanisms that may contribute to the lack of adherence of these cells to the laminae in horses with laminitis. The cells afflicted with laminitis will

be compared to those of clinically normal horses. By using laser capture microdissection to collect the specific layer of cells at the point of failure, a better understanding of the role that the laminar epithelial cells play in this disease will become clear. It is hoped that the results of this work will pave the way for the development of effective treatments to combat this devastating disease. Dr. Silveira and Team Receive USDA Cochran Fellowship Award to Train Veterinarians

Drs. Fernando Silveira, Luke Heider, Wondwossen Gebreyes, and Bayleyegn Molla (Department of Preventive Medicine) have been awarded a new training grant from the USDA sponsored Cochran Fellowship Award. The main objective of the training program is to raise the professional veterinary skills and knowledge of veterinary fellows from Armenia and Georgia, expose the fellows to advanced veterinary practices and thus help them to improve animal health systems in Armenia and Georgia. The training program will focus on a) Introducing the fellows to the US private veterinary business operations,

veterinary business organizations, producers, government organizations and veterinary associations. The Cochran Fellowship Program (CFP) provides U.S.-based agricultural training opportunities for senior and mid-level specialists and administrators from public and private sectors that are concerned with agricultural trade, agribusiness development, management, policy,

and marketing. The Cochran Fellowship Program has trained over 14,300 Fellows from 123 countries around the world since it's inception in 1984. Drs. Schober and Todd Publishes Findings of Feline Cardiomyopathy Study

Hypertrophic cardiomyopathy (HCM) is the most common cardiac disorder in the domestic cat and is regarded as a disease of cardiac muscle with a diverse morphological and clinical spectrum. Dr. Karsten Schober (Associate Professor, Department of Veterinary Clinical Sciences) and Dr. Amanda Todd (OSU DVM 2010 and Summer Research Program Alumni) have recently published a retrospective study that addressed the general hypothesis that abnormalities of the mitral valve apparatus are common in cats with idiopathic hypertrophic cardiomyopathy (HCM) and contribute to

dynamic obstruction of the left ventricular outflow tract. Their findings indicate that abnormalities of the mitral valve are common in cats with HCM suggesting a possible role in the pathogenesis of dynamic outflow tract obstruction. Schober KE, Todd A. Echocardiographic assessment of the mitral valve apparatus and the left ventricular outflow tract in cats with hypertrophic cardiomyopathy. J Vet Cardiol 2010;12:1-16. Commercialization and Licensing in the CVM

“Let’s Talk About Laboratory Notebooks” -By Dr. Jean Schelhorn To take advantage of US law in the patent space it is important that researchers use best practices in documenting the research progress and elements that could contribute to an invention. In the US and three other countries, advantage is given to the “first to invent”. In the rest of the world it is “first to file”— in other words, it is a race to the patent office and the

first there has the advantage. When two patents covering the same invention are filed in the US, advantage will go to the first admissible document supporting the invention. For a laboratory notebook to be admissible in a US court of law, the invention documentation must be dated, signed by the inventor and have two witnesses who have read and

understood the document and sign and date such; neither of the witnesses can be associated with the project. An alternative that is admissible in court is a docketed report of invention with appropriate date and time stamps, etc. Here at OSU, forms for submitting reports of invention or creation can be found at http://tlc.osu.edu. They are simple to complete and you have resources available in the College to assist if required. Since one never knows what work will actually result in an invention, following best practices for laboratory notebooks will provide sufficient documentation to support invention or creation. Here are some basics: Obtain a bound lab notebook with sequential page numbering, be careful never to

pull pages from the notebook, use pages sequentially, sign and date your work, and seek witnesses (two) not involved with your work to sequentially witness your signature and the recorded matter for every page.

Use strikeouts across sections that are void of entries so the work is complete as

evidenced in the notebook. If you tape plots, etc., into your notebook, sign and date across the taped area.

If you have lots of interest in this area, please talk to Dr. Schelhorn as she has been following this field for many years and has a handout waiting for you in her office. First to claim one wins one dollar and an autographed copy. By the way, we did have a winner for the January challenge. Many folks are proposing electronic laboratory notebooks be admissible for invention documentation, but to date, the US PTO has not allowed use of electronic media. Stay tuned as there is a local start-up company that is trying to compete in this space – electronic laboratory notebooks. For more information: http://fisher.osu.edu/centers/tlc/

Dr. Rosol appointed as Liaison to the American Registry of Pathology

Dr. Tom Rosol (Professor, Department of Veterinary Biosciences) has been appointed for a three-year term to the American Registry of Pathology (ARP) by the American Veterinary Medical Association. The Registry is charged with building collections of rare and unusual specimens from throughout the country for research and educational purposes. Founded in 1921, ARP is a leading institution that conducts educational courses and second-opinion diagnostic pathology services without fee. One function of the ARP is to expand the scope of activities that Armed Forces Institute of Pathology (AFIP) can undertake by acting as principal liaison to the civilian medical community. This interaction with

the civilian medical sector takes the form of Cooperative Enterprises between ARP and AFIP, which Congress has authorized in the broad areas of medical research, education,

and consultation. Through the Cooperative Enterprise mechanism, ARP receives fees for educational courses and consultations as well as private grant funding that, in turn, is used to enhance the combined mission of both organizations. ARP acts as the sponsoring body for private and public contracts and grants and, with AFIP, appoints Distinguished Scientists who have largely replaced SES members as Chairs of departments. http://www.afip.org/ARP/index.html

Update on Conflict of Interest – Office of Academic Affairs

Each year, the Ohio State University requires all faculty and select research staff and students to complete an electronic financial conflict of interest (CoI) disclosure to comply with federal and state law and University policy. The annual disclosure process has been delayed this year while the University awaits the finalization of proposed changes to federal conflict of interest regulations, which will require faculty, staff and applicable students to provide substantially more information

concerning their external financial relationships. While we await the new rules, please note that current federal regulations and University policy require faculty, research staff and students to update their current conflict of interest disclosures whenever a new significant (greater than $10,000 in the preceding 12 months) financial interest is received. The e-coi update process has been improved and allows faculty, research staff and students to review their current information, insert new information and independently update their disclosures on-line. Our federal sponsors expect that new significant financial interests are to be reported to the University within thirty (30) days of receipt. In fact, this requirement has been placed in the proposed new federal regulations and will be subject to audit, once the law goes into effect. As such, faculty, staff and student researchers who have been on federally-funded projects during the 2010 calendar year need to update their current e-coi disclosures with any new significant financial interests on or before January 31, 2011 to remain in compliance. Additional information concerning the proposed new rules and instructions on updating disclosures can be found on the Office of Research Compliance website at http://orc.osu.edu/coi/forms.cfm or by email at conflictinfo@osu.edu.

NEW VERSION OF "THE GUIDE" NOW AVAILABLE

A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new

scientific information on common laboratory animals, including aquatic species, and includes extensive references. National Academies Press, 1/4.

http://www.nap.edu/catalog.php?record_id=12910

Faculty Judges Needed for Research Forum The Graduate School is working closely with the Council of Graduate Students regarding this year’s Hayes Research Forum, and they eed of faculty judges! Please consider being a volunteer as an abstract judges or presentation judges. They have an acute need for judges in the arts, humanities, engineering, education, FAES, and business. Faculty members interested in reviewing abstracts and/or being judges

should visit the Hayes website and contact Ana Clara Azevedo as soon as possible.

Now in its 25th year, the Edward F. Hayes Graduate Research Forum is co-sponsored by the Council of Graduate Students, the Graduate School, and the Office of Research. Its purposes are to:

Feature excellent research conducted by Ohio State graduate students; Recognize outstanding graduate student scholarship within the University; Encourage graduate students to share their research with the Ohio

State community; Facilitate exchange between students, faculty, administration, and the public.

http://cgs.osu.edu/funding/hayes-research-forum/ COUNCIL FOR RESEARCH ACTIVITIES – UPDATE The Council has received canine and USDA formula funds proposal. The council will meet in February to review the proposals. Reminder: Glen Barber Grants are due Friday February 18, 2011.

SUMMER RESEARCH PROGRAM – Faculty Mentors

Faculty mentors needed for veterinary students applying to the Summer Research Program. If contacted by an inquiring student please respond. This program is designed to offer qualified veterinary students the opportunity to develop and work on a research project under the supervision of a faculty mentor. The program is typically focused during the three month period during

the summer break, but may also assist student research projects throughout the academic year. Specific activities of the program include: student research projects conducted with a faculty mentor, weekly seminars on focused topics ranging from responsible conduct of research to leadership training, field trips to explore interesting research environments or new technology and opportunities to attend national scientific meetings.

Application Process: All materials should be sent as electronic (email) attachments (doc files or PDFs) to Michele Morscher (morscher.1@osu.edu) by 5:00 pm February 4th to be considered for one of the Merial positions. The Ohio State Program deadline is April 1st. The original signed hardcopy should also be submitted to Michele Morscher, 127L VMAB, 1900 Coffey Road, Columbus, OH 43210. For more information: http://vet.osu.edu/research/veterinary-scholar-summer-research-program RECENT GRANT AWARDS & PUBLICATIONS GRANT AWARDS Dr. Stefan Niewiesk: Alios BioPharma, Inc. Testing antivirals against RSV

Drs. David Wilkie and Anne Gemensky: SentrX Animal Care Protocol for the clinical

assessment of the use of SentrX KCS Treatment Gel in reducing clinical symptoms

associated with KCS in dogs

Drs. Bimbo Welker and Lowell Midla: Michigan St. Univ. Supplementing food animal

veterinary medical education with iPod applications, pod casting, and problem based

learning

PUBLICATIONS Schober KE, Hart TM, Stern JA, Li X, Samii VF, Zekas LJ, Scansen B, Bonagura JD. Prediction of acute congestive heart failure in dogs by Doppler echocardiography. J Vet Intern Med 2010;24:1358-1368. Anupam R, Datta A, Kesic M, Green-Church K, Shkriabai N, Kvaratskhelia M, Lairmore MD. Human T-lymphotropic virus type 1 p30 interacts with REGγ and modulates ataxia telangiectasia mutated to promote cell survival. J Biol Chem Jan. 7, 2011 as doi:10.1074/jbc.M110.176354 Lairmore M. 2010. Retroviruses. In: Fenner's Veterinary Virology, Fourth Edition, N. James Maclachlan, Edward J Dubovi (Editors)

Jin J, Jing W, Lei XX, Feng C, Peng S, Boris-Lawrie K, Huang Y. Evidence that Lin28 stimulates translation by recruiting RNA helicase A to polysomes. Nucleic Acids Res. 2011 Jan 18. [Epub ahead of print] PubMed PMID: 21247876. Rauf A, Khatri M, Murgia MV, Saif YM. Expression of perforin-granzyme pathway genes in the bursa of infectious bursal disease virus-infected chickens. Dev Comp Immunol. 2011 Jan 14. [Epub ahead of print] PubMed PMID: 21241730. Iazbik MC, O'Donnell M, Marin L, Zaldivar S, Hudson D, Couto CG. Prevalence of dog erythrocyte antigens in retired racing Greyhounds. Vet Clin Pathol. 2010 Dec;39(4):433-5. doi: 10.1111/j.1939-165X.2010.00261.x. Epub 2010 Oct 29. PubMed PMID: 21198732. Stella JL, Lord LK, Buffington CA. Sickness behaviors in response to unusual external events in healthy cats and cats with feline interstitial cystitis. J Am Vet Med Assoc. 2011 Jan 1;238(1):67-73. PubMed PMID: 21194324. Beauchamp DJ, da Costa RC, Premanandan C, Burns CG, Cui J, Daniels JB. Mycoplasma felis-associated meningoencephalomyelitis in a cat. J Feline Med Surg. 2010 Dec 20. [Epub ahead of print] PubMed PMID: 21177132. Yu X, Si J, Zhang Y, Dewille JW. CCAAT/Enhancer Binding Protein-delta (C/EBP-delta) regulates cell growth, migration and differentiation. Cancer Cell Int. 2010 Dec 9;10:48. PubMed PMID: 21143913; PubMed Central PMCID: PMC3004888.

SEMINARS, MEETINGS AND WORKSHOPS

Interesting in writing funded grants? We have a workshop for you!

The CVM Office of Research and Graduate Studies, in co-Sponsorship with the OSU Office of Research, the College of Food, Agricultural, and Environmental Sciences (CFAES), Ohio Agricultural Research and Development Center (OARDC), and Ohio State Extension (OSUE) is offering a one-day workshop on Writing Successful Grants to be presented by Dr. David Morrison of Grant Writers' Seminars and Workshops, LLC.

The target audience includes researchers involved in the veterinary medicine, biomedical sciences, and agriculture, i.e., faculty, research staff, postdoctoral students, and PhD candidates.

8:30 a.m. - 4:30 p.m. on Thursday, February 10, 2011 Registration and payment information is now available. Choose one of two locations. Register for the Columbus location Register for the Wooster location.

Key Topics • Fundamental principles of grant writing to any agency, e.g., NIH, NSF, and USDA • How to develop an irresistible idea for a grant application • Tips on how to write for your reviewers • How to identify the most applicable source of funding for an idea • How to use the internet to your advantage • Tips and strategies for resubmitting Presenter: David Morrison, PhD Yale (Molecular Biology and Biophysics). Dr. Morrison was continuously funded since the early 1970s by NIH (including a ten-year MERIT award), foundations, and industry. He is a member of multiple national review panels and advisory groups; recipient of awards for teaching excellence and innovation. A continental breakfast reception and lunch will be provided. Participants will also receive all workshop handouts and a copy of The Grant Application Writer's Workbook. Parking information is available. Registration fee is $50 for researchers from a sponsoring college (VetMed & CFAES), payable by 100W or check made out to The Ohio State University. Please include your name with all payment information. Please note registrations are on a first-come, first-served basis for this workshop. Your registration is not complete until we receive payment. Please contact Kate Hayes-Ozello for more information. Kathleen.Hayes-Ozello@cvm.osu.edu

QI presentation 'Qualitative Research and NSF' Jan. 28 Deborah Winslow, program director of the Cultural Anthropology program at the National Science Foundation, will visit campus and present "Qualitative Research and NSF" on Friday (1/28) from 2-3:30 p.m. in 4012 Smith Laboratory. The talk is open to the public. Read more: https://qualinq.wikidot.com/meeting

The OSUCCC-James 13th Annual Scientific Meeting will be held on Feb. 18, 2011 at the Ohio Union Please join your fellow members of The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute for a day that highlights and celebrates the latest research from the Ohio State Cancer Program. This is an event that includes broad participation and reflects the breadth of cancer research performed here across our seven key programs. The day will include engaging presentations from keynote speakers outside of OSU as well as presentations from within our membership, a large poster review covering our seven programs and Shared Resources, the second annual Art of Cancer Research competition, our annual

awards and more. OSUCCC-James membership is encouraged to submit abstracts and posters for this event, which will help to foster programmatic interaction and collaboration. http://cancer.osu.edu/research/researcheducation/meetingsconferences/2011asm/pages/index.aspx

CCTS TO SPONSOR ‘TOOLS OF THE TRADE’ EVENT FEB. 22 Ohio State’s Center for Clinical and Translational Science (CCTS) will present Tools of the Trade, an event for early investigators who need resources to get their research up and running, from 8 a.m.-3 p.m. on Tuesday, Feb. 22, in the Ohio Union Cartoon Room. The event is free and open to investigators from all disciplines across campus. Register online at http://tinyurl.com/29vru35. Read more at http://ccts.osu.edu

CCTS Annual Scientific Meeting March 4, 2011 Translational Therapeutics and

Diagnostics Friday, March 4th 2011 8:00 am – 5:00 pm Biomedical Research Tower. For more information, contact Valerie DeGroff

The 10th Annual OSU College of Medicine Research Day is scheduled to take place Thursday, April 7, 2011, in the OSU Biomedical Research Tower. All OSU Medical Center faculty, staff and students are invited to attend. OSUMC Research Day is part of a coordinated Research Celebration in 2011, including activities organized by the CCTS on April 6 and NCH on April 8. http://researchday.osu.edu/

The Fourth Annual Translational to Clinical (T2C) Wound Care Conference will

be held April 8-9, 2011, at the Ohio Union. Graduate students, MD-PhD students, medical students, postdoctoral trainees, clinical residents or fellows, and undergraduate students enrolled in training programs at the OSU Medical Center are invited to participate in the conference poster session. Research should address tissue injury, repair and inflammation related to all organs. The early-bird deadline for submissions is Feb. 15, 2011. OSU students and fellows who submit abstracts by the early bird deadline will be recognized with a registration fee waiver. For more information on the conference please see http://surgery.osu.edu/woundcenter/

American Society for Microbiology General Meeting in New Orleans May 21-24,

2011. http://gm.asm.org/

Upcoming training offered through the Office of Sponsored Programs

http://osp.osu.edu/training/ o PI Portal Practice Lab – Feb. 10 o Proposal Development and Submission – Feb. 16 o Cayuse Introduction – March 2

o A large number of online topics available as well; see website for more information

GRANT SUPPORT OFFICE – UPDATES Your Grant Support Office has been busy!

Summary for past month: Preparation and editing for: Two NIH R01 grants, a Waltham, an Ohio Third Frontier Application, two USDA applications, an American Heart Association grant application, assisted a canine grant application, set up seven PA005s, and assembled and help write a faculty award nomination.

Current projects: 6 R01s, 2USDA, 2 K awards, 1 award nomination, 1 manuscript.

UPCOMING FUNDING OPPORTUNITIES

Upcoming Intramural Grant Deadlines: February 15, 2011

C. Glenn Barber Fund Grants: http://vet.osu.edu/assets/pdf/research/glennBarberFundGrants.pdf

o 2 positions will be awarded with a start date of 07/1/2011 Follow the instructions and template for Barber Funds:

http://vet.osu.edu/research/grant-application More information can be found at the following link: http://vet.osu.edu/research/intramural-grants or contact: Morscher.1@osu.edu

PELOTONIA FELLOWSHIP PROGRAM ACCEPTING APPLICATIONS The Pelotonia Fellowship Program, funded with money raised by the annual Pelotonia bicycle tour between Columbus and Athens, is accepting applications for undergraduate, graduate, medical and postdoctoral fellowships. These fellowships are awarded for cancer-related research projects but can go to applicants in any field of study. Applications are due March 1. For more information, including eligibility guidelines and an application form, go to http://cancer.osu.edu or e-mail Jeffrey.Mason@osumc.edu.

Grants available to support outreach and engagement Requests for proposals are now available for two sets of grants to support outreach and engagement partnerships. The 2011 Engagement Impact Grants (up to $80,000) aim to establish and/or expand innovative, creative, scholarly outreach and engagement initiatives

that can have a substantial impact within the university and community. The OSU CARES/OSU Extension Seed Grants (up to $10,000 each) fund outreach and engagement initiatives with partners from at least two colleges (including OSU Extension). The deadline for both is Monday (3/14). Read more: http://outreachgrants.osu.edu Extramural Funding Opportunities AKC Canine Health OAK Program pre-proposals due March 1, 2011 www.akcchf.org NIH Funding opportunities NIDA Avante-Garde Award Program for HIV Research due February 11, 2011 http://grants.nih.gov/grants/guide/pa-files/PAR-10-287.html Innovative Emerging Molecular Analysis Technologies (SBIR R43/R44) (RFA-CA-10-013) National Cancer Institute Application Receipt Date: Feb 8, 2011 http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-10-013.html Pilot and Feasibility Clinical Research Grants in Arthritis and Musculoskeletal and Skin Diseases (R21) (PAR-10-282) Application Receipt/Submission Date March 1, 2011 http://grants.nih.gov/grants/guide/pa-files/PAR-10-282.html Advanced in vivo Imaging to Understand Cancer Systems (R01) due February 23, 2011 http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-11-005.html

Shared Instrument Grant Program (S10) due March 23, 2011 http://grants.nih.gov/grants/guide/pa-files/PAR-11-081.html

RFP ANNOUNCEMENT: Respiratory Pathogens Research Centers (RPRC) -- RFP NIAID-DMID-NIHAI2010091) (NOT-AI-11-019) National Institute of Allergy and Infectious Diseases http://grants.nih.gov/grants/guide/notice-files/NOT-AI-11-019.html

New Page Limits for NIH Individual Career Development (K) Award Applications: Due Dates After January 7, 2011 (NOT-OD-11-027) http://grants.nih.gov/grants/guide/notice-files/NOT-OD-11-027.html Advanced Notice of Change in Policy on the Submission of Letters of Reference for Kirschstein-NRSA Fellowship (F) and Career Development (K) Applications: Letters due by same date as proposal, eliminates 5-day grace period. (NOT-OD-11-036) http://grants.nih.gov/grants/guide/notice-files/NOT-OD-11-036.html USDA Opportunities NIFA Higher Education Challenge Grants Due Feb. 4, 2011 http://www.nifa.usda.gov/funding/rfas/pdfs/11_hec.pdf

Organic Agriculture Research and Extension Initiative Grants due February 10, 2011 http://www.nifa.usda.gov/fo/organicagricultureresearchandextensioninitiative.cfm Check the USDA website! http://www.nifa.usda.gov/fo/funding.cfm NSF Opportunities http://www.nsf.gov/funding/pgm_list.jsp?type=xcut

*new* Center for Clinical and Translational Science newsletter available http://ccts.osu.edu/content/ccts-investigator-newsletter

WHAT YOU NEED TO KNOW – Top Deadly Sins of Grant writing

From the blog, Naturally Selected, The Scientist Magazine. http://blog.the-scientist.com/

Favorite top-3 list of deadly sins in grant writing that you’re unlikely to overcome no matter how good your project is:

1. Write highly dense, technical prose that is designed only for a specialist in your field to read.

2. Don’t bother to thoroughly develop your Specific Aims page before launching into writing the text of your proposal.

3. Make sure to dive right into the technical details of your elegant experiments, without giving any background about why the project is important in the first place.

For more information please contact Dr. Kate Hayes-Ozello, College of Veterinary Medicine Grants Support Office at Kathleen.Hayes-Ozello@cvm.osu.edu or Ms. Michele Morscher at Michele.Morscher@cvm.osu.edu