research initiatives at ucla’s jonsson comprehensive cancer center (jccc) cancer center overview...
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Research Initiatives at UCLA’s Jonsson Comprehensive Cancer Center (JCCC)
Cancer Center OverviewcaBIG TBPT/ICR Workspaces
Judith Gasson, Ph.D.
Professor and Director, UCLA’s Jonsson Comprehensive Cancer Center
President, Jonsson Cancer Center Foundation
Co-Director, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research
Research Initiatives at UCLA’s Jonsson Comprehensive Cancer Center
• Overview of UCLA’s Jonsson Comprehensive Cancer Center (who, where, what)
• Research Partnerships– Translational therapeutics– Nano-technology– Imaging– Cancer stem cells
• New Opportunities
• Funding Base (direct plus indirect) :
• total funding: $195,000,000
• NCI funding: $46,000,000
Location and Funding Base
Funding Base (direct plus indirect) :
total funding: $195,000,000
NCI funding: $46,000,000
Goals for JCCC• Maintain and enhance outstanding basic, clinical
and population sciences research
• Develop dynamic environment necessary to support clinical trials based on JCCC research
• Develop innovative ways to promote and support bidirectional translational research from the bench to the bedside to the community.
Research Initiatives at UCLA’s Jonsson Comprehensive Cancer Center
– 240 faculty from DGSoM, College, SoPH, Dentistry, Nursing, Engineering……
– Organized into 12 Scientific Program Area
– Supported by 10 Shared Resources• Translational Pathology (Dr. Sarah Dry)• Gene Expression (Dr. Stan Nelson)• Bioinformatics (Dr. Arash Naeim)
JCCC Summary
36th year of funding “Comprehensive” designation by National Cancer Institute
Excellence in all areas of cancer prevention, detection, treatment and survivorship research
Education and outreach to geographic region served
283 actively accruing therapeutic clinical trials45% institutional16.5% new patients accrued to studies
UCLA’s Jonsson Comprehensive Cancer Center Translational therapeutics
• Community- based UCLA Oncology Research Network• Established in 1996 by DJ Slamon• Allows oncology practices throughout the region and nation
to participate in clinical research• Offers highest quality of care available in a comprehensive
& compassionate setting
• Translational Oncology International (TORI)• Formed in 2003• Sites: California, Colorado, Florida, Georgia, Indiana,
Maryland, Nevada, New Mexico, Texas
Herceptin FDA-approved in 1998
Breast cancer (Slamon)
Gleevec FDA-approved in 2001
Chronic myeloid leukemia (Witte, Sawyers)
Avastin FDA-approved 2004
Colon cancer (Kabbinavar)
Tarceva FDA-approved 2004
lung cancer (Prager)
Sprycel FDA-approved 2006
Chronic Myeloid leukemia (Sawyers, Shah)
Tykerb FDA-approved 2007
for HER-2+ breast cancer
How do we measure success?
UCLA’s Jonsson Comprehensive Cancer CenterNano-technology partnerships with Engineering and
Chemistry
• Institute for Cell-Mimetic Space Exploration (CMISE), Chih-Ming Ho, NASA-funded; NCI Nanomedicine Center
• California Nano-Systems Institute (CNSI) UCLA-UCSB, public/private funding
• Cal Tech/ UCLA Pharmacology/ JCCC/ ISB Consortium (Heath, Phelps, Hood) NCI-CCNE Center of Nanotechnology Excellence (7 funded, $18 million)
UCLA’s Jonsson Comprehensive Cancer CenterImaging
• Crump Institute for Molecular Imaging- Mike Phelps– Developing imaging assays for the study of biological
systems including cancer
• In vivo cancer molecular imaging centers- ICMIC Harvey Herschman, NCI funded 5 yrs X2 ($10M).– Translating basic science into improved ways to monitor
cancer and it’s treatment through the marriage of molecular biology, chemistry and imaging.
• JCCC: clinical trial and regulatory expertise, research excellence and shared resources
• Gene Medicine Program: Cell-based therapeutics, research excellence and specialized facilities
• Broad Stem Cell Center: research excellence, shared resources and specialized facilities
Broad Stem Cell Research Center
Human Gene Medicine Program
Jonsson
Comprehensive Cancer Center
ES Cells
JCCC: clinical trial and regulatory expertise, research excellence and shared resources
Gene Medicine Program: Cell-based therapeutics, research excellence and specialized facilities
Broad Stem Cell Center: research excellence, shared resources and specialized facilities
Integration
Opportunities-Partnerships
• Broad Stem Cell Research Center (Witte, Director)– Faculty recruitment– Research space– Shared resources– Funding from CIRM and philanthropy
• UCLA Human Gene Medicine Program (Economou, Kohn)– 48 trials; 340 patients; 85% cancer patients– FDA-compliant GMP suite– 5% of all patients entered on gene therapy trials worldwide
• Provide Formal Classroom Training for authorization of users
• Individualized, secure Omni-lock access
• Assistance/ templates for the development of SoPs (standard operating procedures)
• Full monitoring of all equipment
BSCRC-JCCC Core Stem Cell Laboratory
• Provide Formal Classroom Training for authorization of users
• Individualized, secure Omni-lock access
• Assistance/ templates for the development of SoPs (standard operating procedures)
• Full monitoring of all equipment
Opportunities-Transdisciplinary Initiatives
- Engineered Immunity Project- (JCCC, Gene Med, BSCRC, Cal Tech)
– Tumor microenvironment/ stem cell niche • (Mikkola, Wu)
– Inflammation and cancer • (Herschman, Braun, Dubinett)
– Epigenetics and re-programming • (Plath, Fan, Clark)
– Diet and Nutrition • (Arab, Heber, Liu, Estrin)
Opportunities-Transdisciplinary Initiatives
– Biomarker discovery/microfluidics for diagnostic• (Tseng, Heath)
– Cancer stem cells and novel inhibitors • (Slamon, Witte, Wu, Kornblum, Pietras)
– Cancer Genetics • (Ganz, Nelson)
– Anemia of cancer • (T. Ganz, Dorigo, Lichtenstein, Finn, Dubinett)
– High resolution sequencing and analysis of purified glioblastoma stem cells
• (Nelson, Kornblum, Mischel)
Jonsson Comprehensive Cancer Center
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