Welcome to the Fall 2010 TBPT MeetingDr. Paul KlotmanPresident and CEOBaylor College of Medicine

November 3, 2010

History of History of Baylor College of MedicineBaylor College of Medicine

Founded in 1900 in Dallas Second oldest medical school in Texas Moved to Houston in 1943 In 1947, moved to present site in Cullen Building –

first building constructed in the Texas Medical Center In 1969, the College separated from Baylor University

to become an independent medical school

Baylor College of Medicine Baylor College of Medicine 19471947

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The Texas Medical Center NowThe Texas Medical Center Now

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The University of TexasHealth Science Center

University of

HoustonBaylorUniversi

ty

Harris CountyHospital District

Clinical and Academic Programs are Greatly Enhanced by Outstanding Affiliated and Collaborating Academic Institutions

and Hospitals

America’s Best Graduate Schools Published by US News & World Report: 2011 Rankings

• Research Medical Schools: BCM #24

• Graduate Schools: BCM #26 (out of over 400)

• Physician Assistant: BCM #9

• Nurse Anesthesia: BCM #11

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Patient CarePatient Care

• Baylor College of Medicine and its eight affiliated teaching hospitals are internationally recognized for medical excellence. Fifty percent of the patients cared for in the Texas Medical Center are treated by a Baylor physician.

• Texas Children’s Hospital• DeBakey Veterans Affairs Medical Center• Ben Taub General Hospital• Memorial Hermann – The Institute for Rehabilitation & Research • The Menninger Clinic• St. Luke’s Episcopal Hospital• M.D. Anderson Cancer Center• The Methodist Hospital

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Multiple Specialty Centers for Research Multiple Specialty Centers for Research and Patient Careand Patient Care

• Dan L. Duncan Cancer CenterDan L. Duncan Cancer Center

• Lester & Sue Smith Breast CenterLester & Sue Smith Breast Center

• Diabetes and Endocrinology Research CenterDiabetes and Endocrinology Research Center

• Human Genome Sequencing CenterHuman Genome Sequencing Center

• Huffington Center on AgingHuffington Center on Aging

• Center for Space MedicineCenter for Space Medicine

• Center for Cell and Gene TherapyCenter for Cell and Gene Therapy

• Stem Cells and Regenerative Medicine CenterStem Cells and Regenerative Medicine Center

9Source: National Science Foundation, February 2010

ResearchResearch

Federally Financed Research Expenditures Texas Colleges and Universities – FY 2008

State-wide NIH Grant Funding 2009

UT AustinBAYLOR COLLEGE OF MEDICINETexas A&M University UT SouthwesternUT M. D. AndersonUTHSC HoustonUTMB GalvestonUTHSC San AntonioRice UniversityUniversity of HoustonTexas A&M HSCUT El PasoUT San AntonioUT DallasUT ArlingtonUniversity of North Texas HSCTexas Tech University

$324.3 million262.5 million245.6 million201.5 million194.9 million129.3 million122.0 million121.8 million

55.0 million43.2million33.0 million26.9 million21.5 million21.4 million20.7 million19.8 million19.7 million

$202.4 million167.9 million148.5 million103.2 million

89.1 million85.5 million53.5 million29.6 million21.4 million17.8 million17.1 million14.8 million12.8 million12.7 million11.7 million

9.8 million7.1 million5.9 million

BAYLOR COLLEGE OF MEDICINEUT SouthwesternUT M.D. Anderson UTMB GalvestonUTHSC HoustonUTHSC San AntonioUT AustinSW Foundation for Biomedical ResearchTexas A&M- College StationTexas A&M HSCUniversity of North Texas HSCUniversity of HoustonUT San AntonioRice UniversityUT El PasoBaylor Research Institute- DallasTexas Tech University HSCUT Dallas

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Baylor College of MedicineBaylor College of MedicineResearch Funding FY 2011Research Funding FY 2011

• Federal funding $344 million• Private/other funding $56

million

• Total Research funding $400 million

Dan L. Duncan Cancer Center at Baylor College of Medicine

Mission of the DLDCCMission of the DLDCC

Reduce suffering and mortality from cancer Reduce suffering and mortality from cancer through research, education, patient care, and through research, education, patient care, and outreach into the community, especially the outreach into the community, especially the underserved.underserved.

DLDCC is a Matrix CenterDLDCC is a Matrix Center

• The Dan L. Duncan Cancer Center is comprised of: The Dan L. Duncan Cancer Center is comprised of:

Baylor College of Medicine – Scientific LeaderBaylor College of Medicine – Scientific Leader Clinical AffiliatesClinical Affiliates

Ben Taub General HospitalBen Taub General Hospital Michael E. DeBakey Veterans Affairs Medical CenterMichael E. DeBakey Veterans Affairs Medical Center Texas Children's Hospital Texas Children's Hospital

Baylor ClinicBaylor Clinic

Dan L. DuncanCancer Center

Breast Center

Center for Cell and Gene Therapy

Stem Cell and Regenerative

Medicine Center

Genome Center

Chemical Genomics Program

Children’s Nutrition Research Center

Rice, Methodist, MD Anderson

breastpancreaslivercolonlymphoma prostateleukemiabrain

Research EnvironmentResearch Environment

Shared ResourcesShared Resources

Biostatistics and InformaticsBiostatistics and Informatics Cell Processing and Vector ProductionCell Processing and Vector Production Clinical Trials Support UnitClinical Trials Support Unit Flow CytometryFlow Cytometry Genetically Engineered MouseGenetically Engineered Mouse Genome-wide RNAi Screening and AnalysisGenome-wide RNAi Screening and Analysis Genomic ProfilingGenomic Profiling Human Tissue Acquisition/PathologyHuman Tissue Acquisition/Pathology Integrated MicroscopyIntegrated Microscopy Protein Expression/ProteomicsProtein Expression/Proteomics Population Sciences Bio-repositoryPopulation Sciences Bio-repository

Membership & Grant SupportMembership & Grant Support

Research Members Research Members 189189Clinical Investigators Clinical Investigators 43 43

NCI GrantsNCI Grants $44 million$44 millionOther NIHOther NIH $59 million$59 millionOther peer reviewOther peer review $10 million$10 millionIndustryIndustry $2 million$2 millionNon peer reviewNon peer review $11 million$11 million

Total Cancer Funding Total Cancer Funding $126 million$126 million

Cancer Prevention and Research Cancer Prevention and Research Institute of Texas (CPRIT)Institute of Texas (CPRIT)

• A Remarkable Commitment of the State of Texas to Cancer A Remarkable Commitment of the State of Texas to Cancer Research; 3 Billion Dollars over 10 yearsResearch; 3 Billion Dollars over 10 years

• Peer reviewed cancer research; 10% for education, Peer reviewed cancer research; 10% for education, prevention and screeningprevention and screening

• Focus on multi-disciplinary and multi-institutional “statewide” Focus on multi-disciplinary and multi-institutional “statewide” initiatives; commercial potentialinitiatives; commercial potential

• In 2010, Baylor received more than $38 million in CPRIT In 2010, Baylor received more than $38 million in CPRIT fundingfunding

Research ProgramsResearch Programs

7 Cancer Center Support Grant 7 Cancer Center Support Grant ProgramsPrograms

Cancer BiologyCancer Biology

Viral & Molecular OncogenesisViral & Molecular Oncogenesis

Nuclear ReceptorsNuclear Receptors

Cancer Prevention & Population Cancer Prevention & Population SciencesSciences

Cancer Cell & Gene TherapyCancer Cell & Gene Therapy

Breast CancerBreast Cancer

Pediatric CancerPediatric Cancer

• Developing programs inDeveloping programs in

• Pancreas CancerPancreas Cancer

• Prostate CancerProstate Cancer

• Gastrointestinal CancerGastrointestinal Cancer

Clinical TrialsClinical Trials

204 Therapeutic Clinical Trials Currently Open204 Therapeutic Clinical Trials Currently Open

59 of these are Investigator Initiated59 of these are Investigator Initiated

13% of New Patients Accrued to Clinical Trials13% of New Patients Accrued to Clinical Trials

Office of Outreach & Office of Outreach & Health DisparitiesHealth Disparities

Screening programs with Harris County Hospital DistrictScreening programs with Harris County Hospital District

Inter-cultural Cancer CouncilInter-cultural Cancer Council

Texas Comprehensive Cancer CoalitionTexas Comprehensive Cancer Coalition

Physician Oncology Education ProgramPhysician Oncology Education Program

Partner with community organizations to address health Partner with community organizations to address health disparitiesdisparities

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