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Factors affecting teratogenesis1-

Effects of timing of exposure :Is critical in determining the potential effect of the teratogen

Rubella virus: or German measles identified by the Australian ophthalmologistnamed

Norman Greggwho observed that an epidemic cases of congenital cataracts closely followed

an epidemic of rubella He illustrates importance of the critical periods, since the type of

malformation isclosely related to the time of exposure Where :child born with rubella

(Congenital rubella syndrome (CRS)Eye malformationsand heart problemswere observed

when exposure was mostlyclose tofirst 8 weeksof development Defenses were seen to

corresponding exposure between 8 -12 weeks of development

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