recent and eagerly anticipated advances in hearing ... handouts/treat dizzy... · recent and...
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Recent and Eagerly Recent and Eagerly Anticipated Advances in Anticipated Advances in Hearing DisordersHearing Disorders
American Hearing Research American Hearing Research Foundation gala Foundation gala ---- 20062006
Timothy C. Hain, M.DTimothy C. Hain, M.DProfessor, NorthwesternProfessor, Northwestern
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Recent advancesRecent advances
MeniereMeniere’’s diseases disease–– Uncommon disorder (1/2000)Uncommon disorder (1/2000)–– Hearing loss, tinnitus, and vertigoHearing loss, tinnitus, and vertigo–– Chronic diseaseChronic disease
Hydrops
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MeniereMeniere’’s diseases diseaseOld treatment paradigmOld treatment paradigm
Salt restriction and/or diureticSalt restriction and/or diureticVestibular suppressants for dizzinessVestibular suppressants for dizzinessDestroy inner ear for severe casesDestroy inner ear for severe cases–– Often results in deafnessOften results in deafness
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New treatmentNew treatment
Low dose GentamicinLow dose GentamicinInjection into earInjection into ear80% effective80% effectiveNo side effectsNo side effects
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LowLow--dose gentamicin is a dose gentamicin is a remarkable advanceremarkable advance
Better quality of life for MeniereBetter quality of life for Meniere’’s s sufferersufferer’’ssLess or no medicationLess or no medicationNo damage to ear from treatment No damage to ear from treatment itselfitself
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PresentPresentand near future: Bionic ears and near future: Bionic ears
Cochlear implant Cochlear implant –– for bilateral for bilateral deafnessdeafnessRemarkable advanceRemarkable advanceRestores hearingRestores hearing
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Bilateral vestibular loss Bilateral vestibular loss can be equally disablingcan be equally disabling
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Vestibular implant Vestibular implant –– for for bilateral vestibular lossbilateral vestibular loss
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Prosthetic Semicircular CanalProsthetic Semicircular CanalBeing developed at Mass Eye/EarBeing developed at Mass Eye/Ear
Sensor
Battery Circuitry
Cover
Source: Rick Lewis, MEEI
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10 years 10 years –– Hair cell Hair cell regenerationregeneration
Since 1970Since 1970’’s, known that Sharks, s, known that Sharks, Frogs and Birds can reFrogs and Birds can re--grow their hair grow their hair cells in inner earcells in inner ear
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10 years 10 years –– Hair cell Hair cell regenerationregeneration
Experiment: Give a bird a drug that Experiment: Give a bird a drug that kills inner earkills inner earResult: deaf birdResult: deaf birdWait 4 monthsWait 4 monthsResult: bird hears againResult: bird hears again
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Birds and People are not Birds and People are not that differentthat different
It should be possible to turn on the same gene that Birds/Sharks/Frogs use in people, and regenerate the inner ear
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Early research (2003)Early research (2003)
Hair cells Hair cells regenerated in regenerated in Guinea pigsGuinea pigsBy injection of a By injection of a gene (math1) into gene (math1) into the inner ear, the inner ear, scientists coaxed scientists coaxed the ears of normal the ears of normal adult guinea pigs adult guinea pigs to sprout new hair to sprout new hair cells. cells.
K. Kawamoto et al.Neurosci. 2003 Jun 1;23(11):4395-400.
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Regeneration in deaf Regeneration in deaf mammals (guinea pigs), mammals (guinea pigs), 20052005
–– The same group improved hearing in deaf The same group improved hearing in deaf animals using similar methodanimals using similar method
–– Demonstration of cellular and functional Demonstration of cellular and functional repair in the ear of a mature deaf repair in the ear of a mature deaf mammal. mammal.
––IzumikawaIzumikawa MM, , MinodaMinoda RR, , Kawamoto KKawamoto K, , AbrashkinAbrashkin KAKA, , SwiderskiSwiderski DLDL, , Dolan DFDolan DF, , BroughBrough DEDE, , Raphael YRaphael Y. . Auditory hair cell replacement and Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals. hearing improvement by Atoh1 gene therapy in deaf mammals. Nat Med. Nat Med. 2005 Mar;11(3):2492005 Mar;11(3):249--50.50.
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Hair Cell RegenerationHair Cell Regeneration
Huge potential benefit !Huge potential benefit !–– Eliminate need for most hearing aids Eliminate need for most hearing aids –– No need for cochlear implantNo need for cochlear implant–– Eliminate one class of dizziness by Eliminate one class of dizziness by
regrowingregrowing inner earinner ear
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The Future Looks The Future Looks Promising for Hearing !Promising for Hearing !
Better treatmentsBetter treatmentsTechnical advancesTechnical advancesRegenerationRegeneration
Support Hearing Research !Support Hearing Research !