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Like antidepressants (ADs) and anticonvulsants / antiepileptic drugs (AEDs), antipsychotics (APs) are broken

up into different classes based upon things like chemical structure and ho they ork in your brain!

Like AEDs there is some overlapping membership! "urrently the primary classification of APs is

acombination of hen they ere developed and ho they ork (pharmacodynamics)!

 First Generation Antipsychotic Agents / Neuroleptics 1.

#ith the e$ception of lithium carbonate and %aldol (haloperidol), all first generation antipsychotic agents

(&'As), also knon as standard antipsychotics and typical antipsychotics, ere thought to ork in the e$act

same ay binding to D dopamine, *+ muscarine, %+ histamine, and maybe even a little alpha+

noradrenergic receptors to interfere ith the reception of those neurotransmitters (D, *+, %+ and +

antagonists)! -he only differences being chemical structure, potency at the various receptors, here in your

 brain this ould happen, and each drug.s pharmacokinetics! %aldol is different in that it doesn.t do much as far 

as *+ and %+ are concerned, and is a lot more potent in binding to alpha+, so its side effect profile is

somehat different!

#ith better technology and more competition for grant money, researchers are looking back at &'As to see

ho they ork! -urns out they all don.t ork the same ay after all and some (lo$apine, chlorprothi$ene, e!g!)

are like %aldol in that they are a lot more like atypical / secondgeneration antipsychotics than &'As!

 List of First Generation / Standard / Typical Antipsychotic Agents 1.1

• -horaine (chlorpromaine %"l)

• fluphenaine decanoate

• Proli$in (fluphenaine %"l)

• 0erentil (mesoridaine besylate)

• -rilafon (perphenaine)

• "ompaine (prochlorperaine)

• *ellaril (thioridaine %"l)

• 0telaine trifluoperaine %"l

• %aldol (haloperidol)

• haloperidol decanoate

• Lo$itane (lo$apine succinate)

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• *oban (molindone %"l)

• 1rap (pimoide)

•  2avane (thiothi$ene)

• 0erpasil (reserpine)

• -aractan / -ru$al (chlorprothi$ene)

• 0ordinol (clopenthi$ol)

• Depi$ol / &luan$ol (flupenti$ol)

• flupenti$ol deconate

• "lopi$ol / Acuphase (uclopenthi$ol)

• uclopenthi$ol deconate

0ubsets of &'As3

 Phenothiazines 1.21

• -horaine (chlorpromaine %"l)

• fluphenaine decanoate

• Proli$in (fluphenaine %"l)

• 0erentil (mesoridaine besylate)

• -rilafon (perphenaine)

• "ompaine (prochlorperaine)

•

*ellaril (thioridaine %"l)

• 0telaine trifluoperaine %"l

 Thioanthenes 1.!

•  2avane (thiothi$ene)

http://crazymeds.us/pmwiki/pmwiki.php/MedClass/APClasses#_note-1http://crazymeds.us/pmwiki/pmwiki.php/Meds/Thorazinehttp://crazymeds.us/pmwiki/pmwiki.php/MedClass/APClasses#_note-1http://crazymeds.us/pmwiki/pmwiki.php/Meds/Thorazine

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• -aractan / -ru$al (chlorprothi$ene)

• 0ordinol (clopenthi$ol)

• Depi$ol / &luan$ol (flupenti$ol)

• flupenti$ol deconate

• "lopi$ol / Acuphase (uclopenthi$ol)

• uclopenthi$ol deconate

Second Generation Antipsychotic Agents / Neuroleptics 2.

0econd generation antipsychotic agents (0'As), A4A atypical APs (AAPs) do a hell of a lot more than most

&'As! -hey are broadspectrum antagonists of dopamine, alphanoradrenergic, and serotonin receptors!

E$cept for 5isperdal (risperidone) and 6nvega(paliperidone) hich is 5isperdal.s active metabolite (i!e!

 predigested 5isperdal) in pill form no to of them ork the e$act same ay, hence the term 7atypical8!

Although it.s no unclear if 6nvega does a little more than 5isperdal, or maybe they missed something

that 5isperdal does! "loaril (cloapine), 9ypre$a (olanapine) and 0aphris (asenapine) are fairly close in

 pharmacodynamics, and they bind to practically every neurotransmitter receptor you.ve got,

hile 5isperdal / 6nvega don.t do much more than %aldol (haloperidol) does! 0ince they are no prescribed

far more often than &'As, the term 7atypical8 to describe them, and 7standard8 to describe the older  APs, is

counterintuitive! 0o &'A and 0'A are the preferred terms among researchers! 1n most consumeroriented

mental health sites the term 7atypical antipsychotic8 (AAP) is still used far more often!

 List of Second Generation / Atypical Antipsychotic Agents 2.1

• 9ypre$a (olanapine)

• 0ero:uel (:uetiapine)

• 'eodon (iprasidone)

•

&anapt (iloperidone)

• 0aphris (asenapine)

• 5isperdal (risperidone)

• 6nvega (paliperidone)

http://crazymeds.us/pmwiki/pmwiki.php/MedClass/APshttp://crazymeds.us/pmwiki/pmwiki.php/MedClass/APshttp://crazymeds.us/pmwiki/pmwiki.php/Risperdal/Risperdalhttp://crazymeds.us/pmwiki/pmwiki.php/Invega/Invegahttp://crazymeds.us/pmwiki/pmwiki.php/Invega/Invegahttp://crazymeds.us/pmwiki/pmwiki.php/Invega/Invegahttp://crazymeds.us/pmwiki/pmwiki.php/Risperdal/Risperdalhttp://crazymeds.us/pmwiki/pmwiki.php/Risperdal/Risperdalhttp://crazymeds.us/pmwiki/pmwiki.php/Risperdal/Risperdalhttp://crazymeds.us/pmwiki/pmwiki.php/Risperdal/Risperdalhttp://crazymeds.us/pmwiki/pmwiki.php/Risperdal/Risperdalhttp://crazymeds.us/pmwiki/pmwiki.php/Zyprexa/Zyprexahttp://crazymeds.us/pmwiki/pmwiki.php/Risperdal/Risperdalhttp://crazymeds.us/pmwiki/pmwiki.php/Risperdal/Risperdalhttp://crazymeds.us/pmwiki/pmwiki.php/Invega/Invegahttp://crazymeds.us/pmwiki/pmwiki.php/Invega/Invegahttp://crazymeds.us/pmwiki/pmwiki.php/MedClass/APshttp://crazymeds.us/pmwiki/pmwiki.php/MedClass/APshttp://crazymeds.us/pmwiki/pmwiki.php/Meds/Zyprexahttp://crazymeds.us/pmwiki/pmwiki.php/Meds/Seroquelhttp://crazymeds.us/pmwiki/pmwiki.php/Meds/Seroquelhttp://crazymeds.us/pmwiki/pmwiki.php/Meds/Geodonhttp://crazymeds.us/pmwiki/pmwiki.php/Meds/Geodonhttp://crazymeds.us/pmwiki/pmwiki.php/Meds/Risperdalhttp://crazymeds.us/pmwiki/pmwiki.php/Meds/Risperdalhttp://crazymeds.us/pmwiki/pmwiki.php/Meds/Invegahttp://crazymeds.us/pmwiki/pmwiki.php/MedClass/APshttp://crazymeds.us/pmwiki/pmwiki.php/Risperdal/Risperdalhttp://crazymeds.us/pmwiki/pmwiki.php/Invega/Invegahttp://crazymeds.us/pmwiki/pmwiki.php/Invega/Invegahttp://crazymeds.us/pmwiki/pmwiki.php/Risperdal/Risperdalhttp://crazymeds.us/pmwiki/pmwiki.php/Risperdal/Risperdalhttp://crazymeds.us/pmwiki/pmwiki.php/Zyprexa/Zyprexahttp://crazymeds.us/pmwiki/pmwiki.php/Risperdal/Risperdalhttp://crazymeds.us/pmwiki/pmwiki.php/Invega/Invegahttp://crazymeds.us/pmwiki/pmwiki.php/MedClass/APshttp://crazymeds.us/pmwiki/pmwiki.php/Meds/Zyprexahttp://crazymeds.us/pmwiki/pmwiki.php/Meds/Seroquelhttp://crazymeds.us/pmwiki/pmwiki.php/Meds/Geodonhttp://crazymeds.us/pmwiki/pmwiki.php/Meds/Risperdalhttp://crazymeds.us/pmwiki/pmwiki.php/Meds/Invega

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• Latuda (lurasidone)

• "loaril (cloapine)

• 0olian (amisulpride)

• Asendin (amo$apine) 0ee belo

#hile officially classified as a tetracyclic antidepressant (-"A), Asendin (amo$apine) is being unofficially

classified as an 0'A  by 0tahl and other pharmacologists, based upon its efficacy in treating

schiophrenia and mechanism of action!

Third Generation Antipsychotic Agents / Neuroleptics 3.

Third generation antipsychotic agents (TGAs) are APs that are both dopamine

antagonists (interfering with dopamine reception) and partial agonists (stabilizingdopamine reception). Abilify (aripiprazole) is the first TGA on the market, several more

are nder development ! in varios clinical trial phases.

• Abilify (aripiprazole)

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