preface - 東京大学preface it is our great pleasure to present our annual report 2018 for the...

PrefaceIt is our great pleasure to present our Annual Report 2018 for the Institute of Medi-

cal Science, The University of Tokyo (IMSUT). The predecessors to IMSUT wasfounded in 1892 as the Institute of Infectious Diseases (IID) by Dr. Shibasaburo Ki-tasato and incorporated into the University of Tokyo in 1916. In that era, infectiousdiseases were the greatest threat to our daily lives and the IID was the center for re-search into infectious diseases in Asia and a top center for the world, as well.In 1967, our institute received its present name when we reorganized it to encom-

pass a wider range of medical sciences to meet the demands of modern medical careafter World War II. In addition to infectious diseases, our research areas have nowgrown to include cellular and molecular biology, cancer biology, immunology,genome science, experimental animal disease model research, stem cell/iPS biology,vaccine development and other related areas. Thus, our current research spectrumtook form and IMSUT gained respect as a research institute focused on medical sci-ence.From the IID's very beginning, our scientific forefathers carried out both basic re-

search on pathogens and applied studies to feed their findings back into improvedpatient care for the prevention and treatment of infectious diseases. This tradition or"institutional DNA" has been passed down to present-day IMSUT: our goal remainsdiscovery through basic medical research and innovation of medical care and preven-tion through translational research. Reflecting this central paradigm, our affiliatedhospital is an important asset for the execution of our mission of "bench to bed" and"bed to bench" research immediately within our institute.In 2017, our institute marked the 125th anniversary of its founding as the IID and

the 50th anniversary of its reorganization and renaming to IMSUT. With an eye to-ward the future beyond our 125th anniversary, we have been pursuing the initiative"IMSUT One to Gogo (125/50)," and are working together to transform IMSUT into ayet more advanced, world-leading research institute in medical science. In 2018, as thefirst outcome of this "beyond 125" initiative, IMSUT was authorized as the Interna-tional Joint Usage/Research Center for biomedical research by the Ministry of Educa-tion, Culture, Science, Sports and Technology, Japan in 2018.This annual report summarizes our scientific achievements in 2018. I sincerely hope

that these achievements will inspire yet further advances, promote worldwide collabo-rations with our scientists, and ultimately contribute to improve health care aroundthe world.

January 2019

Yoshinori Murakami, M.D., Ph.D.DeanThe Institute of Medical ScienceThe University of Tokyo

Organization and Faculty Members機構および職員

Department of Microbiology and Immunology 感染・免疫部門

Division of Virology …………………………………………………………………………………１８ウイルス感染分野Professor Yoshihiro Kawaoka, D.V.M., Ph.D.Project Professor Makoto Yamashita, Ph.D.Associate Professor Masaki Imai, D.V.M., Ph.D.Project Associate Professor Satoshi Fukuyama, M.D., Ph.D.Project Associate Professor Tokiko Watanabe, D.V.M., Ph.D.Project Associate Professor Seiya Yamayoshi, D.V.M., Ph.D.Assistant Professor Kiyoko Iwatsuki-Horimoto, D.V.M., Ph.D.Assistant Professor Shinya Yamada, Ph.D.Project Assistant Professor Maki Kiso, D.V.M., Ph.D.Research Associate Yuko Sakai-Tagawa, Ph.D.

教授獣医学博士河岡義裕特任教授薬学博士山下誠准教授博士（獣医学）今井正樹特任准教授博士（医学）福山聡特任准教授博士（獣医学）渡邉登喜子特任准教授博士（医学）山吉誠也助教博士（獣医学）岩附（堀本）研子助教博士（医学）山田晋弥特任助教博士（医学）木曽真紀助手博士（医学）坂井（田川）優子

Division of Infectious Genetics ……………………………………………………………………２３感染遺伝学分野Professor Kensuke Miyake, M.D., Ph.D.Associate Professor Shin-Ichiroh Saitoh, Ph.D.Assistant Professor Ryutaro Fukui, Ph.D.Assistant Professor Takuma Shibata, Ph.D.Project Assistant Professor Ryota Sato, Ph.D.

教授医学博士三宅健介准教授博士（医学）齋藤伸一郎助教博士（医学）福井竜太郎助教博士（医学）柴田琢磨特任助教博士（医学）佐藤亮太

Division of Molecular Virology ……………………………………………………………………２６ウイルス病態制御分野Professor Yasushi Kawaguchi, D.V.M., Ph.D.Assistant professor Akihisa Kato, Ph.D.Assistant professor Jun Arii, Ph.D.Assistant professor Naoto Koyanagi, Ph.D.

教授博士（獣医学）川口寧助教博士（医学）加藤哲久助教博士（獣医学）有井潤助教博士（生命科学）小栁直人

〈as of December, 2018〉

1

Department of Cancer Biology 癌・細胞増殖部門

Division of Molecular Pathology……………………………………………………………………２９人癌病因遺伝子分野Professor Yoshinori Murakami, M.D., Ph.D.Project Professor Takayuki MorisakiAssistant Professor Takeshi Ito, Ph.D.

教授医学博士村上善則特任教授医学博士森崎隆幸助教博士（医学）伊東剛

Division of Cellular and Molecular Biology………………………………………………………３２分子発癌分野Professor Jun-ichiro Inoue, Ph.D.Associate Professor Takeharu Sakamoto, Ph.D.Assistant Professor Yuu Taguchi, Ph.D.Assistant Professor Mizuki Yamamoto, Ph.D.

教授薬学博士井上純一郎准教授博士（医学）坂本毅治助教博士（医学）田口祐助教博士（医学）山本瑞生

Division of Genetics …………………………………………………………………………………３６腫瘍抑制分野Professor Yuji Yamanashi, Ph.D.Assistant Professor Tohru Tezuka, Ph.D.Assistant Professor Ryo Ueta, Ph.D.Assistant Professor Sumimasa Arimura, Ph.D.Assistant Professor Akane Inoue-Yamauchi, Ph.D.

教授理学博士山梨裕司助教博士（理学）手塚徹助教博士（生命科学）植田亮助教博士（医学）有村純暢助教博士（医学）山内（井上）茜

Division of Cancer Cell Biology ……………………………………………………………………４１癌防御シグナル分野Professor Makoto Nakanishi, M.D., Ph.D.Associate Professor Atsuya Nishiyama, Ph.D.Assistant Professor Yoshikazu Johmura, Ph.D.

教授医学博士中西真准教授博士（理学）西山敦哉助教博士（薬学）城村由和

Department of Basic Medical Sciences 基礎医科学部門

Division of Neuronal Network………………………………………………………………………４４神経ネットワーク分野Professor Toshiya Manabe, M.D., Ph.D.Assistant Professor Hiroyuki Katagiri, Ph.D.Assistant Professor Shizuka Kobayashi, Ph.D.Assistant Professor Takahiko Chimura, Ph.D.

教授医学博士真鍋俊也助教博士（医学）片桐大之助教博士（生命科学）小林静香助教博士（理学）千村崇彦

Division of Cell Signaling and Molecular Medicine ……………………………………………４６分子シグナル制御分野Professor Mutsuhiro Takekawa, M.D., Ph.D.Assistant Professor Yuji Kubota, Ph.D.Assistant Professor Takanori Nakamura, Ph.D.

教授博士（医学）武川睦寛助教博士（理学）久保田裕二助教博士（理学）中村貴紀

2

Affiliated Research Facilities 附属研究施設等

Human Genome Center ヒトゲノム解析センター

Laboratory of DNA Information Analysis…………………………………………………………５０DNA情報解析分野

Laboratory of Sequence Analysisシークエンスデータ情報処理分野

Laboratory of Genome Databaseゲノムデータベース分野Professor Satoru Miyano, Ph.D.Associate Professor Rui Yamaguchi, Ph.D.Assistant Professor Yao-zhong Zhang, Ph.D.Associate Professor Tetsuo Shibuya, Ph.D.Assistant Professor Kotoe Katayama, Ph.D.Project Assistant Professor Taku Onodera, Ph.D.

教授理学博士宮野悟准教授博士（理学）山口類助教博士（情報理工学）張燿中准教授博士（理学）渋谷哲朗助教博士（工学）片山琴絵特任助教博士（情報理工学）小野寺拓

Laboratory of Molecular Medicine…………………………………………………………………５８ゲノム医科学分野Professor Tatsuhiro Shibata, M.D., Ph.D.Assistant Professor Satoshi Yamasaki, Ph.D.

教授医学博士柴田龍弘助教博士（農学）山﨑智

Laboratory of Genome Technology ………………………………………………………………６２シークエンス技術開発分野Professor Satoru Miyano, Ph.D.Professor Koichi Matsuda, M.D., Ph.D.

Project Senior Assistant Professor Makoto Hirata, M.D., Ph.D.Assistant Professor Chizu Tanikawa, Ph.D.

教授（兼務）理学博士宮野悟連携教授博士（医学）松田浩一（新領域創成科学研究科）特任講師博士（医学）平田真助教博士（医学）谷川千津

Laboratory of Functional Analysis In Silico ……………………………………………………７０機能解析イン・シリコ分野Professor Kenta Nakai, Ph.D.Senior Assistant Professor Ashwini Patil, Ph.D.Project Senior Assistant Professor Sung-Joon Park, Ph.D.

教授博士（理学）中井謙太講師博士（理学）パティルアシュウィニ特任講師博士（工学）朴聖俊

Department of Public Policy ………………………………………………………………………７６公共政策研究分野Professor Kaori Muto, Ph.D.Associate Professor Yusuke Inoue, Ph.D.Project Assistant Professor Akiko Nagai, Ph.D.

教授博士（保健学）武藤香織准助教博士（社会医学）井上悠輔特任助教博士（医科学）永井亜貴子

3

Center for Experimental Medicine and Systems Biology システム疾患モデル研究センター

Division of Stem Cell Pathology……………………………………………………………………７９先進病態モデル研究分野Professor Yasuhiro Yamada, M.D., Ph.D.Assistant Professor Masaki Yagi, Ph.D.Assistant Professor Sho Ohta, Ph.D.

教授博士（医学）山田泰広助教博士（医科学）八木正樹助教博士（生命科学）太田翔

Laboratory of Innate Immunity ……………………………………………………………………８１自然免疫研究分野Professor Kensuke Miyake, M.D., Ph.D. 教授医学博士三宅健介

Laboratory of Reproductive Systems Biology …………………………………………………８３生殖システム研究分野Project Professor Masahito Ikawa, Ph.D.Associate Professor Manabu Ozawa, Ph.D.

特任教授博士（薬学）伊川正人准教授博士（農学）小沢学

Laboratory of Systems Biology ……………………………………………………………………８６システムズバイオロジー研究分野Associate Professor Susumu Nakae, Ph.D. 准教授博士（農学）中江進

Advanced Clinical Research Center 先端医療研究センター

Division of Molecular Therapy ……………………………………………………………………９１分子療法分野Professor Arinobu Tojo, M.D., D.M.Sc.Associate Professor Satoshi Takahashi, M.D., D.M.Sc.Assistant Professor Muneyoshi Futami, M.D., D.M.Sc.Assistant Professor Seiichiro Kobayashi, M.D., D.M.Sc.

教授医学博士東條有伸准教授博士（医学）高橋聡助教博士（医学）二見宗孔助教博士（医学）小林誠一郎

Division of Cellular Therapy ………………………………………………………………………９８細胞療法分野Professor Toshio Kitamura, M.D., D.M.Sc.Associate Professor Susumu Goyama, M.D., D.M.Sc.Assistant Professor Tomofusa Fukuyama, M.D., D.M.Sc.Assistant Professor Yosuke Tanaka, Ph.D.

教授医学博士北村俊雄准教授博士（医学）合山進助教博士（医学）福山朋房助教博士（理学）田中洋介

Division of Infectious Diseases……………………………………………………………………１０２感染症分野Professor Hiroshi Yotsuyanagi, M.D., D.M.Sc.Associate Professor Takeya Tsutsumi, M.D., D.M.Sc.Assistant Professor Michiko Koga, M.D., D.M.Sc.

教授博士（医学）四柳宏准教授博士（医学）堤武也助教博士（医学）古賀道子

Division of Clinical Genome Research …………………………………………………………１０５臨床ゲノム腫瘍学分野Professor Yoichi Furukawa, M.D., Ph.D.Associate Professor Tsuneo Ikenoue, M.D., Ph.D.Project Senior Assistant Professor Kiyoshi Yamaguchi, Ph.D.Assistant Professor Kiyoko Takane, M.D., Ph.D.

教授博士（医学）古川洋一准教授博士（医学）池上恒雄特任講師博士（薬学）山口貴世志助教博士（医学）高根希世子

4

Division of Innovative Cancer Therapy …………………………………………………………１０８先端がん治療分野Professor Tomoki Todo, M.D., Ph.D.Associate Professor Yasushi Ino, M.D., Ph.D.Project Associate Professor Minoru Tanaka, M.D., Ph.D.Senior Assistant Professor Hiroyuki Momota, M.D., Ph.D.Assistant Professor Lushun Chalise, M.D., Ph.D.Assistant Professor Yoshinori Sakata, M.D., Ph.D.

教授博士（医学）藤堂具紀准教授博士（医学）稲生靖特任准教授博士（医学）田中実講師博士（医学）百田洋之助教博士（医学）チャリセルシュン助教博士（医学）坂田義詞

Division of Advanced Medicine Promotion ……………………………………………………１１０先端医療開発推進分野Professor Fumitaka Nagamura, M.D., D.M.Sc.Associate Professor Masanori Nojima, M.D., Ph.D., M.P.H.

教授博士（医学）長村文孝准教授博士（医学）野島正寛

Division of Advanced Genome Medicine ………………………………………………………１１２先端ゲノム医学分野Associate Professor Yoshihiro Hirata, M.D., Ph.D. 准教授博士（医学）平田喜裕

Division of Bioethics ………………………………………………………………………………１１５生命倫理研究分野Associate Professor Ayako Kamisato, Ph.D. 准教授博士（法学）神里彩子

Center for Stem Cell Biology and Regenerative Medicine 幹細胞治療研究センター

Division of Stem Cell and Molecular Medicine…………………………………………………１１７幹細胞分子医学分野Professor Atsushi Iwama, M.D., Ph.D.Assistant Professor Motohiko Oshima, Ph.D.Project Assistant Professor Yaeko Nakajima, Ph.D.

教授博士（医学）岩間厚志助教博士（医学）大島基彦特任助教博士（医学）中島やえ子

Division of Stem Cell Transplantation……………………………………………………………１２０幹細胞移植分野Professor Arinobu Tojo, M.D., D.M.Sc.Associate Professor Satoshi Takahashi, M.D., D.M.Sc.

教授医学博士東條有伸准教授博士（医学）高橋聡

Division of Stem Cell Processing…………………………………………………………………１２３幹細胞プロセシング分野Associate Professor Makoto Otsu, M.D., Ph.D. 准教授博士（医学）大津真

Division of Stem Cell Signaling……………………………………………………………………１２６幹細胞シグナル制御分野Professor Toshio Kitamura, M.D., D.M.Sc. 教授医学博士北村俊雄

Division of Stem Cell Dynamics …………………………………………………………………１２９幹細胞ダイナミクス解析分野Associate Professor Beate Heissig, M.D., Ph.D. 准教授医学博士ハイジッヒ，ベアーテ

5

Division of Stem Cell Cellomics …………………………………………………………………１３１幹細胞セロミクス分野Project Associate Professor Hiroshi Watarai, Ph.D. 特任准教授博士（医学）渡会浩志

Stem Cell Bank ………………………………………………………………………………………１３５ステムセルバンクAssociate Professor Makoto Otsu, M.D., Ph.D. 准教授博士（医学）大津真

FACS Core Laboratory………………………………………………………………………………１３８FACSコアラボラトリーAssociate Professor Makoto Otsu, M.D., Ph.D. 准教授（兼務）博士（医学）大津真

International Research Center for Infectious Diseases 感染症国際研究センター

Department of Special Pathogens ………………………………………………………………１３９高病原性感染症系Professor Chieko Kai, D.V.M., Ph.D.Professor Yoshihiro Kawaoka, D.V.M., Ph.D.Project Assistant Professor Akihiro Sugai, Ph.D.

教授（兼）農学博士甲斐知恵子教授（兼）獣医学博士河岡義裕特任助教博士（獣医学）菅井亮宏

Department of Infectious Disease Control………………………………………………………１４３感染制御系Professor Yasushi Kawaguchi, D.V.M., Ph.D.Assistant professor Akihisa Kato, Ph.D.Assistant professor Jun Arii, Ph.D.Assistant professor Naoto Koyanagi, Ph.D.

教授（兼）博士（獣医学）川口寧助教（兼）博士（医学）加藤哲久助教（兼）博士（獣医学）有井潤助教（兼）博士（生命科学）小栁直人

Department of Infectious Disease Control, Division of Viral Infection ……………………１４６感染制御系・ウイルス学分野Associate Professor Takeshi Ichinohe, Ph.D. 准教授博士（工学）一戸猛志

Department of Infectious Disease Control, Division of Bacteriology ……………………１４８感染制御系・細菌学分野Associate Professor Hitomi Mimuro, Ph.D. 准教授博士（医学）三室仁美

Department of Infectious Disease Control, Division of Systems Virology ………………１５１感染制御系・システムウイルス学分野Associate Professor Kei Sato, Ph.D. 准教授博士（医学）佐藤佳

Pathogenic Microbes Repository Unit……………………………………………………………１５３病原微生物資源室Associate Professor Hitomi Mimuro, Ph.D. 准教授博士（医学）三室仁美

6

International Research and Development Center for Mucosal Vaccines国際粘膜ワクチン開発研究センター

Division of Mucosal Barriology……………………………………………………………………１５５粘膜バリア学分野Professor Kensuke Miyake, Ph.D.Visiting Professor Koji Hase, Ph.D.Visiting Associate Professor Shintaro Sato, Ph.D.Project Assistant Professor Taketoshi Mizutani, Ph.D.

教授医学博士三宅健介客員教授博士（薬学）長谷耕二客員准教授博士（医学）佐藤慎太郎特任助教博士（医学）水谷壮利

Division of Innate Immune Recognition…………………………………………………………１５８自然免疫制御分野Project Professor Satoshi Uematsu, M.D., Ph.D.Project Assistant Professor Kosuke Fujimoto, M.D., Ph.D.

特任教授博士（医学）植松智特任助教博士（医学）藤本康介

Division of Clinical Vaccinology …………………………………………………………………１６１臨床ワクチン学分野Project Professor Kohtaro Fujihashi, D.D.S., Ph.D.Project Associate Professor Yosuke Kurashima, Ph.D.

特任教授博士（歯学）藤橋浩太郎特任准教授博士（医学）倉島洋介

Division of Mucosal Vaccines ……………………………………………………………………１６３粘膜ワクチン学分野Professor Kensuke Miyake, Ph.D.Visiting Professor Jun Kunisawa, Ph.D.Visiting Associate Professor Tomonori Nochi, Ph.D.Project Senior Assistant Professor Rika Nakahashi, Ph.D.

教授（兼務）医学博士三宅健介客員教授博士（薬学）國澤純客員准教授博士（農学）野地智法特任講師博士（医学）中橋理佳

Division of Mucosal Symbiosis……………………………………………………………………１６７粘膜共生学分野Invited Professor Tetsuro Matano, M.D., D.M.Sc.Project Associate Professor Yoshiyuki Goto, Ph.D.Project Assistant Professor Miho Uematsu, Ph.D.

委嘱教授博士（医学）俣野哲朗特任准教授博士（医学）後藤義幸特任助教博士（医学）植松未帆

Health Intelligence Center ヘルスインテリジェンスセンター

Division of Health Medical Data Science ………………………………………………………１６９健康医療データサイエンス分野Professor Seiya Imoto, Ph.D.Assistant Professor Takanori Hasegawa, Ph.D.

教授博士（数理学）井元清哉助教博士（情報学）長谷川嵩矩

Division of Health Medical Computational Science……………………………………………１７３健康医療計算科学分野Professor Satoru Miyano, Ph.D.Assistant Professor Atsushi Niida, Ph.D.

教授理学博士宮野悟助教博士（理学）新井田厚司

7

Center for Gene & Cell Therapy …………………………………………………………………１７６遺伝子・細胞治療センターProfessor Arinobu Tojo, M.D., D.M.Sc.Professor Tomoki Todo, M.D., Ph.D.Professor Toshio Kitamura, M.D., D.M.Sc.Professor Fumitaka Nagamura, M.D., D.M.Sc.Project Professor Shin-ichi Muramatsu, M.D., Ph.D.Project Professor Hideaki Tahara, M.D., D.M.Sc.Project Professor Kenzaburo Tani, M.D., Ph.D.Invited Professor Koji Tamada, M.D., Ph.D.Associate Professor Satoshi Takahashi, M.D., D.M.Sc.Associate Professor Makoto Otsu, M.D., Ph.D.Associate Professor Tokiko Nagamura-Inoue, M.D., Ph.D.

教授（兼務）医学博士東條有伸教授（兼務）博士（医学）藤堂具紀教授（兼務）医学博士北村俊雄教授（兼務）博士（医学）長村文孝特任教授（非常勤）博士（医学）村松慎一特任教授（兼務）医学博士田原秀晃特任教授（兼務）医学博士谷憲三朗教授（委嘱）博士（医学）玉田耕治准教授（兼務）博士（医学）高橋聡准教授（兼務）博士（医学）大津真准教授（兼務）博士（医学）長村登紀子

Laboratory Animal Research Center ……………………………………………………………１７８実験動物研究施設Professor Chieko Kai, D.V.M., Ph.D.Associate Professor Misako Yoneda, D.V.M., Ph.D.Project Senior Assistant Professor Hiroki Sato, Ph.D.Assistant Professor Tomoko Fujiyuki, Ph.D.Assistant Professor Shotaro Uchida, Ph.D.

教授農学博士甲斐知恵子准教授博士（農学）米田美佐子特任講師博士（理学）佐藤宏樹助教博士（薬学）藤幸知子助教博士（医学）内田翔太郎

Amami Laboratory of Injurious Animals…………………………………………………………１８０奄美病害動物研究施設Professor Chieko Kai, D.V.M., Ph.D.Assistant Professor Shinichi Yokota, D.V.M., Ph.D.

教授農学博士甲斐知恵子助教博士（人間科学）横田伸一

Medical Proteomics Laboratory …………………………………………………………………１８２疾患プロテオミクスラボラトリーProfessor Jun-ichiro Inoue, Ph.D.Professor Kouhei Tsumoto, Ph.D.Associate Professor Masaaki Oyama, Ph.D.Assistant Professor Makoto Nakakido, Ph.D.

Assistant Professor Daisuke Kuroda, Ph.D.

Project Assistant Professor Hiroshi Sagara, Ph.D.

教授薬学博士井上純一郎教授博士（工学）津本浩平准教授博士（医学）尾山大明助教博士（生命科学）中木戸誠（大学院工学系研究科）助教博士（理学）黒田大祐（大学院工学系研究科）特任助教博士（医学）相良洋

8

Research Center for Asian Infectious Diseases ………………………………………………１９５アジア感染症研究拠点Professor Yasushi Kawaguchi, D.V.M., Ph.D.Professor Jun-ichiro Inoue, Ph.D.Professor Yoshihiro Kawaoka, D.V.M., Ph.D.Project Professor Mitsue Hayashi, Ph.D.Project Professor Zene Matsuda, M.D., Ph.D., D.Sc.Project Associate Professor Takaomi Ishida, Ph.D.Project Associate Professor Seiya Yamayoshi, D.V.M., Ph.D.Project Senior Assistant Professor Jin Gohda, Ph.D.Assistant Professor Mizuki Yamamoto, Ph.D.Assistant Professor Akihisa Kato, Ph.D.Assistant Professor Jun Arii, Ph.D.Assistant Professor Naoto Koyanagi, Ph.D.

教授（兼務）博士（獣医学）川口寧教授（兼務）薬学博士井上純一郎教授（兼務）獣医学博士河岡義裕特任教授法学博士林光江特任教授医学博士松田善衛特任准教授博士（医学）石田尚臣特任准教授博士（医学）山吉誠也特任講師博士（薬学）合田仁助教（兼務）博士（医学）山本瑞生助教（兼務）博士（医学）加藤哲久助教（兼務）博士（獣医学）有井潤助教（兼務）博士（生命科学）小栁直人

Laboratory of Molecular Genetics (Frontier Research Unit)…………………………………１９９遺伝子解析施設（フロンティア研究領域）Professor Yoshinori Murakami, M.D., Ph.D.Associate Professor Kazuo Tatebayashi, Ph.D.

教授医学博士村上善則准教授博士（薬学）舘林和夫

IMSUT Hospital 附属病院

Department of Medicine (Department of Hematology/Oncology) …………………………２０２内科（血液腫瘍内科）Professor Arinobu Tojo, M.D., D.M.Sc.Associate Professor Satoshi Takahashi, M.D., D.M.Sc.Associate Professor Yoichi Imai, M.D., Ph.D.Associate Professor Tokiko Nagamura-Inoue, M.D., D.M.Sc.Project Associate Professor Hiroshi Yasui, M.D., D.M.Sc.Assistant Professor Tomohusa Fukuyama, M.D., D.M.Sc.Assistant Professor Seiko Kato, M.D., D.M.Sc.Assistant Professor Takaaki Konuma, M.D., D.M.Sc.Assistant Professor Seiichiro Kobayashi, M.D., D.M.Sc.Assistant Professor Muneyosi Futami, M.D., D.M.Sc.Assistant Professor Toyotaka Kawamata, M.D., D.M.Sc.Assistant Professor Kazuaki Yokoyama, M.D., D.M.Sc.Assistant Professor Junya Makiyama, M.D., D.M.Sc.

教授医学博士東條有伸准教授博士（医学）高橋聡准教授博士（医学）今井陽一准教授博士（医学）長村登紀子特任准教授博士（医学）安井寛助教博士（医学）福山朋房助教博士（医学）加藤せい子助教博士（医学）小沼貴晶助教博士（医学）小林誠一郎助教博士（医学）二見宗孔助教博士（医学）川俣豊隆助教博士（医学）横山和明助教博士（医学）牧山純也

Department of Infectious Diseases and Applied Immunology………………………………２０６感染免疫内科Head, Professor Hiroshi Yotsuyanagi, M.D., D.M.Sc.Senior Assistant Professor Tomohiko Koibuchi, M.D., D.M.Sc.Assistant Professor Michiko Koga, M.D., D.M.ScAssistant Professor Eisuke Adachi, M.D., D.M.Sc.

教授博士（医学）四柳宏講師博士（医学）鯉渕智彦助教博士（医学）古賀道子助教博士（医学）安達英輔

Department of Rheumatology and Allergy………………………………………………………２０９アレルギー免疫科Professor Hirotoshi Tanaka, M.D., D.M.Sc.Senior Assistant Professor Noritada Yoshikawa, M.D., D.M.Sc.Assistant Professor Hiroki Yamazaki, M.D., D.M.Sc.

教授（兼務）医学博士田中廣壽講師博士（医学）吉川賢忠助教博士（医学）山崎広貴

9

Department of General Medicine …………………………………………………………………２１２総合診療科Head, Professor Hiroshi Yotsuyanagi, M.D., D.M.Sc.Project Professor Takayuki Morisaki, M.D., D.M.Sc.Associate Professor Yoshihiro Hirata, M.D., D.M.Sc.Senior Assistant Professor Yasuo Matsubara, M.D., D.M.Sc.Project Assistant Professor Yasuki Hijikata, M.D., D.M.Sc.

教授（兼務）博士（医学）四柳宏特任教授（兼務）医学博士森崎隆幸准教授（兼務）博士（医学）平田喜裕講師博士（医学）松原康朗特任助教（兼務）博士（医学）土方康基

Department of Applied Genomics ………………………………………………………………２１５ゲノム診療科Professor Yoichi Furukawa, M.D., Ph.D.Professor Yoshinori Murakami, M.D., Ph.D.Associate Professor Tsuneo Ikenoue, M.D., Ph.D.

教授（兼務）博士（医学）古川洋一教授（兼務）医学博士村上善則准教授（兼務）博士（医学）池上恒雄

Department of Radiology …………………………………………………………………………２１７放射線科

Department of Radiological Technology放射線部Associate Professor Akira Kunimatsu, M.D., D.M.Sc.Senior Assistant Professor Hiroyuki Akai, M.D., D.M.Sc.Assistant Professor Koichiro Yasaka, M.D., D.M.Sc.Head Radiologic Technologist Yoshirou Satake, RT

准教授博士（医学）國松聡講師博士（医学）赤井宏行助教博士（医学）八坂耕一郎放射線技師長佐竹芳朗

Department of Palliative Medicine ………………………………………………………………２２１緩和医療科Professor Arinobu Tojo, M.D., D.M.Sc.Assistant Professor Naoki Shimada, M.D., Ph.D.

教授医学博士東條有伸助教博士（農学）島田直樹

Department of Surgery………………………………………………………………………………２２３外科Professor Arinobu Tojo, M.D., D.M.Sc.Associate Professor Masaru Shinozaki, M.D., Ph.D.Senior Assistant Professor Giichiro Tsurita, M.D., Ph.D.Clinical Senior Assistant Professor Kentaro Yazawa, M.D., Ph.D.

教授（兼）医学博士東條有伸准教授博士（医学）篠崎大講師博士（医学）釣田義一郎病院講師博士（医学）谷澤健太郎

Department of Anesthesia …………………………………………………………………………２２５麻酔科Associate Professor Ryo Orii, M.D., Ph.D.Assistant Professor Reiko Shibata, M.D.

准教授博士（医学）折井亮助教医学士柴田玲子

Department of Joint Surgery ………………………………………………………………………２２７関節外科Senior Assistant Professor Hideyuki Takedani, M.D. D.M.Sc.Assistant Professor Kumiko Ono, M.D. D.M.Sc.

講師博士（医学）竹谷英之助教博士（医学）大野久美子

10

Department of Surgical Neuro-Oncology ………………………………………………………２２８脳腫瘍外科Professor Tomoki Todo, M.D., Ph.D.Associate Professor Yasushi Ino, M.D., Ph.D.Project Associate Professor Minoru Tanaka, M.D., Ph.D.Senior Assistant Professor Hiroyuki Momota, M.D., Ph.D.Assistant Professor Seisaku Kanayama, M.D.Assistant Professor Lushun Chalise, M.D., Ph.D.Assistant Professor Yoshinori Sakata, M.D., Ph.D.(Thoracic surgeon)

教授博士（医学）藤堂具紀准教授博士（医学）稲生靖特任准教授博士（医学）田中実講師博士（医学）百田洋之助教金山政作助教博士（医学）チャリセルシュン助教博士（医学）坂田義詞（呼吸器外科医）

Department of Medical Informatics ………………………………………………………………２３０医療情報部Associate Professor Akira Kunimatsu, M.D., D.M.Sc.Senior Assistant Professor Hiroyuki Akai, M.D., D.M.Sc.Assistant Professor Koichiro Yasaka, M.D., D.M.Sc.

准教授博士（医学）國松聡講師博士（医学）赤井宏行助教博士（医学）八坂耕一郎

Department of Cell Processing and Transfusion………………………………………………２３１セルプロセッシング・輸血部Associate Professor Tokiko Nagamura-Inoue, M.D., Ph.D.Assistant Professor Kazuaki Yokoyama, M.D., Ph.D.Assistant Professor Toyotaka Kawamata, M.D., Ph.D.

准教授博士（医学）長村登紀子助教博士（医学）横山和明助教博士（医学）川俣豊隆

Surgical Center ………………………………………………………………………………………２３４手術部Professor Tomoki Todo, M.D., Ph.D.Project Associate Professor Minoru Tanaka, M.D., Ph.D.

教授博士（医学）藤堂具紀特任准教授博士（医学）田中実

Department of Laboratory Medicine ……………………………………………………………２３５検査部Professor ArinobuTojo, M.D., D.M.Sc.Assistant Professor Tomohiro Ishigaki, M.D., D.M.Sc.

教授医学博士東條有伸助教博士（医学）石垣知寛

Center for Clinical Safety and Infection Control ………………………………………………２３７医療安全・感染制御センター

Department of Clinical Trial Safety Management医療安全管理部

Head, Professor Hiroshi Yotsuyanagi, M.D., D.M.Sc.Associate Professor Yoichi Imai, M.D., D.M.Sc.Head Nurse Hatsuko NaritaAssociate Professor Ayako Kamisato, D.M.Sc.

教授博士（医学）四柳宏准教授博士（医学）今井陽一看護師長成田初子准教授博士（医学）神里彩子

Department of Iinfection Prevention and Control感染制御部

Senior Assistant Professor Tomohiko Koibuchi, M.D., D.M.Sc.Assistant Professor Eisuke Adachi, M.D., D.M.Sc.Nurse Manager Miya KogayuPharmacist Shunsuke KobayashiClinical laboratory technician Hiroko Shibata

講師博士（医学）鯉渕智彦助教博士（医学）安達英輔看護師長小粥美香薬剤師小林俊介臨床検査技師柴田浩子

11

Center for Translational Research ………………………………………………………………２３８トランスレーショナルリサーチ・治験センターProfessor Fumitaka Nagamura, M.D., D.M.Sc.Associate Professor Masanori Nojima, M.D., Ph.D., M.P.H.Project Associate Professor Hiroshi Yasui, M.D., Ph.D.

教授（兼務）博士（医学）長村文孝准教授（兼務）博士（医学）野島正寛特任准教授（兼務）博士（医学）安井寛

Center for Antibody and Vaccine Therapy………………………………………………………２４０抗体・ワクチンセンターProfessor Hirotoshi Tanaka, M.D., D.M.Sc.Professor Kouhei Tsumoto, Ph.D.Project Professor Yataro Daigo, M.D., D.M.Sc.Project Associate Professor Satoru Nagatoishi, Ph.D.Senior Assistant Professor Noritada Yoshikawa, M.D., D.M.Sc.Project Senior Assistant Professor Atsushi Takano, M.D., D.M.Sc.

教授医学博士田中廣壽教授（兼務）博士（工学）津本浩平特任教授博士（医学）醍醐弥太郎特任准教授博士（生命科学）長門石曉講師（兼務）博士（医学）吉川賢忠特任講師博士（医学）高野淳

Therapeutic Vector Development Center ………………………………………………………２４９治療ベクター開発センターProfessor Tomoki Todo, M.D., Ph.D.Associate Professor Yasushi Ino, M.D., Ph.D.

教授博士（医学）藤堂具紀准教授博士（医学）稲生靖

IMSUT CORD …………………………………………………………………………………………２５０臍帯血・臍帯バンクAssociate Professor Tokiko Nagamura-Inoue, M.D., PhD. 准教授博士（医学）長村登紀子

Department of Nursing………………………………………………………………………………２５２看護部Director Koji Kobayashi, RN, Ph.D.Deputy Director Minayo Hisahara, RN.Deputy Director Fumiko Kasuya, RN, CNA.Nurse Manager Mayumi Tanii, RN, MSN, CNA.

Nurse Manager Hatsuko Narita, RN.Nurse Manager Mika Kogayu, RN, MSN.Nurse Manager Tomoko Sato, RN.Nurse Manager Masako Ozawa, RN.Nurse Manager Hiromi Isshiki, RN.

看護部長博士（保健学）小林康司副看護部長久原みな代副看護部長認定看護管理者粕谷文子看護師長修士（看護学）・認定看護管理者

谷井真弓看護師長成田初子看護師長修士（看護学）小粥美香看護師長佐藤朋子看護師長小澤昌子看護師長一色裕美

Department of Pharmacy……………………………………………………………………………２５４薬剤部Director Seiichiro KurodaVice director Takeo YasuPharmacist Kenji Momo

薬剤部長黒田誠一郎副薬剤部長安武夫薬剤師百賢二

Department of AIDS Vaccine Development ……………………………………………………２５６エイズワクチン開発担当Invited Professor Tetsuro Matano, M.D., D.M.Sc.Visiting Associate Professor Ai Kawana-Tachikawa, D.M.Sc.

教授（委嘱）博士（医学）俣野哲朗客員准教授博士（医学）立川（川名）愛

12

IMSUT Distinguished Professor Units東京大学特任教授部門

Division of Stem Cell Therapy ……………………………………………………………………２５９幹細胞治療部門Project Professor Hiromitsu Nakauchi, M.D., Ph.D.Project Associate Professor Tomoyuki Yamaguchi, Ph.D.Project Associate Professor Eiji Mizutani, Ph.D.Project Associate Professor Satoshi Yamazaki, Ph.D.Project Assistant Professor Hideki Masaki, Ph.D.

特任教授医学博士中内啓光特任准教授博士（医学）山口智之特任准教授博士（農学）水谷英二特任准教授博士（生命科学）山﨑聡特任助教博士（理学）正木英樹

Division of Mucosal Immunology…………………………………………………………………２６３粘膜免疫学部門Project Professor Hiroshi Kiyono, D.D.S., Ph.D.Project Associate Professor Yosuke Kurashima, Ph.D.Project Senior Assistant Professor Rika Nakahashi, Ph.D.

特任教授医学博士清野宏特任准教授（兼務）博士（医学）倉島洋介特任講師（兼務）博士（医学）中橋理佳

Corporate Sponsored Research Programs, Social Cooperation Research Programs寄付研究部門・社会連携研究部門

Project Division of Molecular and Developmental Biology …………………………………２６８再生基礎医科学寄付研究部門（ロート製薬，慈照会，VICX，トミー）Project Professor Sumiko Watanabe, Ph.D.Project Senior Assistant Professor Hideto Koso, MD, Ph.D.

特任教授博士（医学）渡辺すみ子特任講師博士（医学）高祖秀登

Project Division of RNA Medical Science ………………………………………………………２７１RNA医科学社会連携研究部門Project Associate Professor Masaki Takahashi, Ph.D.Project Assistant Professor Jeewoong Park, Ph.D.

特任准教授博士（理学）高橋理貴特任助教博士（理学）朴智雄

Project Division of Systems Immunology Research …………………………………………２７３システム免疫学社会連携研究部門（医学生物学研究所）Project Assistant Professor Yasumasa Kimura, Ph.D. 特任助教博士（理学）木村恭将

Project Division of International Advanced Medical Research ……………………………２７６国際先端医療社会連携研究部門Project Associate Professor Koichiro Yuji, M.D., Ph.D. 特任准教授博士（医学）湯地晃一郎

Project Division of ALA Advanced Medical Research ………………………………………２７８ALA先端医療学社会連携研究部門（neo ALA株式会社）Project Professor Kenzaburo Tani, M.D., Ph.D.Project Senior Assistant Professor Yasushi Soda, M.D., Ph.D.Project Assistant Professor Yasuki Hijikata, M.D., Ph.D.Project Assistant Professor Shohei Miyamoto, Ph.D.

特任教授医学博士谷憲三朗特任講師博士（医学）曽田泰特任助教博士（医学）土方康基特任助教博士（医学）宮本将平

Project Division of Fundamental Study on Cutting Edge of Genome Medicine…………２８４先端ゲノム医療の基盤研究寄付研究部門Professor Arinobu Tojo, M.D., D.M.Sc.Project Associate Professor Hiroshi Yasui, M.D., D.M.Sc.

教授（兼務）医学博士東條有伸特任准教授博士（医学）安井寛

13

Project Division of Advanced Biopharmaceutical Science …………………………………２８６先進的バイオ医薬品学社会連携研究部門Professor Hirotoshi Tanaka, Ph.D.Professor Kouhei Tsumoto, Ph.D.Project Associate Professor Satoru Nagatoishi, Ph.D.

教授医学博士田中廣壽教授博士（工学）津本浩平特任准教授博士（生命科学）長門石曉

Project Division of Cancer Biomolecular Therapy ……………………………………………２９１がん生体分子治療社会連携研究部門Project Professor Hideaki Tahara, M.D., Ph.D.Project Associate Professor Hiroaki Uchida, M.D., Ph.D.

特任教授医学博士田原秀晃特任准教授博士（医学）内田宏昭

Dean's Office 所長オフィス

Project Coordination Office ………………………………………………………………………２９５プロジェクトコーディネーター室Professor Mutsuhiro Takekawa, M.D., Ph.D. 教授博士（医学）武川睦寛

Office of Support for Platforms for Advanced Technologies and Research Resources…２９７学術研究基盤支援室Chair and Visiting Professor Kohzoh Imai, M.D., Ph.D. 客員教授医学博士今井浩三

Common Research Facilities 共通施設等

Animal Center動物センターHead Chieko Kai, D.V.M., Ph.D. 教授（兼務）農学博士甲斐知恵子

Culture Media Section培地室Head Jun-ichiro Inoue, Ph.D. 室長（兼務）薬学博士井上純一郎

Library図書室Head Yasushi Kawaguchi, D.V.M., Ph.D. 室長（兼務）博士（獣医学）川口寧

Radioisotope Center放射線管理室Head Kensuke Miyake, M.D., Ph.D. 室長（兼務）医学博士三宅健介

IT Service RoomITサービス室Head Mutsuhiro Takekawa, M.D., Ph.D. 室長（兼務）博士（医学）武川睦寛

Photographic Laboratory写真室Head Mutsuhiro Takekawa, M.D., Ph.D. 室長（兼務）博士（医学）武川睦寛

14

Genetically Modified Microorganism Support Office遺伝子組換え・微生物研究支援室Head Yasushi Kawaguchi, D.V.M., Ph.D. 室長（兼務）博士（獣医学）川口寧

Office of Research Ethics研究倫理支援室Head Kaori Muto, Ph.D.Associate Professor Ayako Kamisato, Ph.D.

室長（兼務）博士（保健学）武藤香織准教授博士（法学）神里彩子

Office of Health and Safety安全衛生管理室Head Makoto Nakanishi, M.D., Ph.D. 室長（兼務）医学博士中西真

Office of lntellectual Property知的財産室Head Jun-ichiro Inoue, Ph.D. 室長（兼務）薬学博士井上純一郎

Advisory Room for Conflict of lnterest利益相反アドバイザリー室Head Hirotoshi Tanaka, M.D., D.M.Sc. 室長（兼務）医学博士田中廣壽

Pathology Core Laboratory病理コアラボラトリーHead of Laboratory I Yoshinori Murakami, M.D., Ph.D.Head of Laboratory II Yasunori Ota, M.D., Ph.D.

Ⅰ室室長（兼務）医学博士村上善則Ⅱ室室長（兼務）博士（医学）大田泰徳

Gene Manipulated Mouse Section発生工学研究支援室Professor Nobuaki Yoshida, M.D., D.M.Sc.Professor Chieko Kai, D.V.M., Ph.D.

教授（兼務）医学博士吉田進昭教授（兼務）農学博士甲斐知恵子

Imaging Core Laboratory顕微鏡コアラボラトリーHead Mutsuhiro Takekawa, M.D., Ph.D. 室長（兼務）博士（医学）武川睦寛

IMSUT Clinical Flow Cytometry LaboratoryIMSUT臨床フローサイトメトリー・ラボHead Arinobu Tojo, M.D., D.M.Sc. 管理者（兼務）医学博士東條有伸

Administration Office事務部General Manager Kiyomi UedaManager of Administrative Affairs Division Toshihide AsakawaManager of Research Support Division Isao UeharaManager of Hospital Division Makoto Hidai

事務部長植田清実管理課長浅川敏秀研究支援課長上原功病院課長比田井真

15

preface - 東京大学preface it is our great pleasure to present our annual report 2018 for the...

Documents