archived as http://www.stealthskater.com/Documents/Pitkanen_114.doc(also …Pitkanen_114.pdf) => doc pdf URL-doc URL-pdf

more from Matti Pitkänen is on the /Pitkanen.htm page at doc pdf URL

note: because important websites are frequently "here today but gone tomorrow", the following was archived from on October `5, 2020. This is NOT an attempt to divert readers from the aforementioned website. Indeed, the reader should only read this back-up copy if the updated original cannot be found at the original author's site.

by Dr. Matti Pitkänen / October 15, 2020

Postal address:Rinnekatu 2-4 A8,03620, Karkkila, Finland

E-mail: matpitka6@gmail.com matpitka@luukku.comURL-address: http://tgdtheory.com

"Blog" forum: http://matpitka.blogspot.com/

We have written together with Reza Rastmanesh several articles related to Biology, Neuroscience, and TGD during this year. Language is indeed what distinguishes us from the other animals in a radical manner and therefore a challenge for any theory of consciousness and life. There are 3 articles related to the origin of language involving one preparatory article explaining the role of magnetic body (MB) in biochemistry (the topic of this posting) and a 2-part article about a model of language.

I decided to put the introductions of the articles to this Blog. Articles can be found also in Research Gate and hopefully sooner or later also at my homepage (my communizations to homepage have been continually terrorized during the summer).

How to compose beautiful light music in bioharmony

TGD-based view about dark matter at the level of Molecular Biology

TGD-based view about the Arrow-of-Time in Neuroscience

Could I go to bed today and wake-up yesterday morning?

DNA and Time Reversal

About the role of possible longitudinal electric field of DNA

New Physics View about Language

http://matpitka.blogspot.com/2020/10/how-compose-beautiful-light-music-in.html

How to compose beautiful light music in bioharmonyThe topic of this article is the detailed definition of the notion of bio-harmony (see this and this). A

sequence of 3-chords of bio-harmony defines a music piece. What rules guarantee that this piece is beautiful? This question is interesting because the chords of bio-harmony correspond to DNA codons.

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TGD

Bio-harmony as a realization of genetic code

TGD leads to a notion of bio-harmony in terms of icosahedral and tetrahedral geometries and 3-chords made of light assigned to the triangular faces of icosahedron and tetrahedron (see this and this). Bio-harmonies are associated with the so-called Hamiltonian cycles which go through every vertex of Platonic solid once. For the icosahedron, the number of vertices is 12, the number of notes in 12-note scale. The 64 codons of bio-harmony represented as light 3-chords formed by dark photon triplets are formed from three 20-chord harmonies associated with icosahedron and the unique 4-chord harmony associated with tetrahedron.

The surprise was that the vertebrate genetic code emerged as a prediction. The numbers of DNA codons coding for a given amino acid are predicted correctly. DNA codons correspond to triangular faces and the orbit of a given triangle under the symmetries of the bio-harmony in question corresponds to DNA codons coding for the amino acid assigned with the orbit.

Codon corresponds to 6 bits. This is information in the usual computational sense . Bio-harmony codes for mood: emotional information related to emotional intelligence as ability to get to the same mood allowing to receive this information. Bio-harmony would be a fundamental representation of information realized already at molecular level. Speech, hearing, and other expressions of information would be based on it. For emotional expression at RNA level possibly involved with conditioning at synaptic level (see this).

About generalizations of the notion of Bio-Harmony

One can consider several generalizations for the notion of bio-harmony.

1. All Platonic solids (in particular, the tetrahedron, cube, octahedron, and dodecahedron) are possible and one can consider the possibility that they also define harmonies in terms of Hamiltonian cycles. Dodecahedron would have 5-chords (pentagons as faces) as basic chords and there is only single harmony. Same mood always, very eastern, and enlightened as also the fact that scale would have 20 notes.

Also, octahedron gives 3-chords (triangular faces) whereas cube gives 4-chords (squares as faces). One can of course speculate with the idea that DNA could also represent this kind of harmonies. Sometimes the 3N rule is indeed broken (for instance, for introns).

2. Galois confinement (see this) allows the possibility to interpret dark genes as sequences of N dark proton triplets as higher level structures behaving like a single quantal unit. This would be true also for the corresponding dark photon sequences consisting of 3N dark photons representing the gene in bio-harmony as an analog of a music piece consisting of 3-chords and played by transcribing it to mRNA.

Basic biomolecules (DNA, RNA, tRNA, amino acids) would have names represented as a sequence of light 3-chords representing a piece of music and dark biomolecules with the same name could recognize and communicate with each other in 3N-resonance. Dark-Ordinary communications could transform dark 3N-photon to single bio-photon so that resonance would be possible when the sum of energies coincides with a transition energy of the ordinary biomolecule. The resonance condition would very effectively select survivors in the fight for survival.

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3. The picture can be viewed even more generally. Any discrete structure, defining graph (in particular, cognitive representation providing a unique finite discretization of space-time surface as points with the coordinates of the 8-D imbedding space coordinates in the extension of rationals) defines harmonies in terms of Hamiltonian cycles. Could also these harmonies make sense?

The restrictions of the cognitive representations to 2-D partonic 2-surfaces would define something analogous to bio-harmony as Hamiltonian cycle of 2-D graph (Platonic surfaces solids can be regarded as 2-D graphs). The interpretation as representations of Galois groups and the notion of Galois confinement is possible although one loses the symmetries of the Platonic solids allowing to identify genetic code.

During the years, I have indeed considered some modifications of the original bio-harmony base on the fusion of 3 icosahedral harmonies and tetrahedral harmony in partcular so called E8 harmony and toric harmony (see this and this). But the overall conclusion (see this) is that the original model is the most plausible candidate.

the challenges of the Model

The model of bio-harmony is far from complete and this article discusses a more detailed definition. Also, the question about the rules defining beautiful music by posing rules on chord sequences are considered. These aesthetic rules are also rules for the corresponding DNA and amino-acid sequences.

1. The fusion of the three harmonies having symmetry groups Zn, n=6,4,2 has been considered but not in the required detail. The Hamiltonian cycles of icosahedron are fixed only modulo isometries of icosahedron preserving the shape of the cycle, scalings of the cycle by a power of quint forming group Z12 leaving the cycle of invariant but inducings transponation (change of the key), and the change of the cycle orientation possibly related to minor-major dichotomy correlating with joyful-sad dichotomy.

For a single icosahedral cycle, these transformations do not change anything. But for the fusion of 3 cycles realized at the same icosahedron, the situation changes and the number of harmonies increases dramatically.

Are all combinations of icosahedral harmonies allowed or are there some natural restrictions on them? I have considered this question. But it seems that there is no good reason for posing any restrictions. The spectrum of harmonies determined by dark genetic codons and therefore the spectrum of emotions at the molecular level would be surprisingly rich.

2. Is it possible to reproduce the basic harmonies of Western music based on the 12-note system which inspired icosahedral harmonies? In particular, can one understand the chords C, F, G of C-major scale?

By octave equivalence, the nearest neighbors of the Hamiltonian cycle are related by quint scaling scaling frequency by factor 3/2 scaling C to G. The 3-chords containing at least one cycle edge contain quint (C→ G) and quint is the basic aspect of bio-harmony. For harmonies with opposite orientation, quints become perfect fourths (C→ F) and FCG corresponds to transponantion of F by two quints.

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For a single icosahedral harmony, the chord-pairs analogous to C-F or C-G do not appear in any obvious manner. If the 3 icosahedral harmonies are related by quint scalings (FCG), the analogs of these chord pairs become natural. Could this be the solution to the problem?

3. What are the rules producing aesthetically satisfying music? I experimented with the ultraconservative assumption that only chord pairs containing common quint are allowed. The result was not ugly. But it was boring. Already the transitions of CFG major scale are too radical for this option!

An attractive idea is that the sequence of 3-chords is continuous in some sense. Could the sense be strictly geometric? Could chord pairs be nearest neighbors in some sense?

For Option I, nearest neighbors have a common edge (3 nearest neighbours). For Option II, they have a common vertex (10 nearest neighbors).

These options do not allow all 3-chord pairs and thus not all possible DNA pairs and all possible amino-acid pairs. A more abstract definition identifies the nearest neighbors with the orbits of nearest neighbors for Option I or II under the symmetry group Zn (n=6,2). Codon is replaced with the codons coding for the same amino-acid. For Option II, this allows us to have all possible chord pairs and therefore DNA and amino-acid pairs.

4. Also, the role of tetrahedral harmony and its relation to start and stop codons is interesting. One wants also to understand why the genetic code at the bio-chemical level is not quite complete and why there are several variants of it.

See the article "How to compose beautiful music of light in bio-harmony"

For a summary of earlier postings, see Latest progress in TGD.

Articles and other material related to TGD.

http://matpitka.blogspot.com/2020/10/tgd-based-view-about-dark-matter-at.htmlTGD-based view about dark matter at the level of Molecular Biology

The basic idea of the TGD-based vision about Living Matter is that dark matter having effective Planck constant heff=nh0 (h=6h0) located at the flux tubes of magnetic body controls ordinary matter. MB would be the boss and biological body the slave.

This hypothesis can be justified by number theoretic vision about TGD which unifies ordinary physics as physics of sensory experience described by real number-based physics and the physics of cognition based on p-adic number fields (real and various p-adic number fields are fused to adele).

Physical motivations for the TGD notion of dark matter

The notion of dark matter as control of biomatter emerged before its number theoretic justification.

1. The findings of Blackman et al about the effects of ELF radiation (in EEG (electroencephalogram) frequency range) on vertebrate brain led to the hypothesis that besides protons.ions alsohave dark variants having heff=nh0 with heff=hgr.

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2. Also, electrons could have these phases. But now the value of heff would be much smaller and satisfy generalized Nottale hypothesis heff=hem where hem is the electromagnetic analogue of hgr assignable to flux tubes assigned with valence bonds. This leads to a model of valence bond (see this) predicting that the value of heff/h0=n=hem increases along the rows of the Periodic Table. This would explain why the molecules such as proteins containing atoms towards the right end of the rows serve as carriers of metabolic energy and why biologically important ions like C++ are towards the left end of the rows.

The energy scale of dark variants of valence electrons is proportional to 1/heff2 so that the

orbital radii are scaled up and the identification as a Rydberg atom is the only possibility in the standard physics picture. Could dark valence electrons be in question? There is empirical evidence known for decades for the mysterious disappearance of valence electrons of some rare earth metals. The article "Lifshitz transition from valence fluctuations in YbAl3" by Chatterjee et al published in Nature Communications (see this) discusses the phenomenon for Yb.

The finding (see this) about misbehaving Ruthenium atoms supports the view that covalent bonds involve dark valence electrons. Pairs of Ru atoms were expected to transform to Ru dimers in thermodynamical equilibrium. But this did not happen. This suggests that valence electrons associated with the valence bond of Ru dimers are dark in TGD sense and the valence bonded Ru dimer has a higher energy than a pair of free Ru atoms.

TGD-based explanation (see this) could be justified by a resonant coupling of the dark electron with an ordinary Rydberg state of the valence electron. In the lowest approximation, the dark valence electron has energies in the spectrum of ordinary valence electrons so that a resonant coupling with Rydberg states can be considered. The evidence found by Randell Mill (see this) for atoms with an abnormally large scale of binding energy suggests the formula h= 6h0

(see this). Adelic physics (see this) predicts heff hierarchy and allows to understand the findings.

3. Nottale hypothesis (see this) introduces the notion of gravitational Planck constant hbargr= GMm/v0 and is in the TGD framework identified as a particular value of heff assignable to gravitational flux tubes (see this). One trivial implication reflecting the Equivalence Principle is that the cyclotron energy spectrum Ec= nhbargreB/m= nGMeB/v0 does not depend on the mass m of the charged particle and is thus universal. The energies involved are proposed to be in the range of biophoton energies (at least) suitable for control of the transitions of the bio-molecule.

The difference between non-organic and in-organic matter would be the presence of dark protons and electrons. The notions of acids and bases would reduce to the presence of dark protons. pH would characterize the fraction of dark protons. The notion of reduction and oxidation (REDOX reaction) would reduce to dark electrons associated with valence bonds (see this).

In biochemistry, the density of dark protons would be much stronger and Pollack effect it in which the irradiation of water in presence of gel phases generates exclusion zones (EZs) as negatively-charged regions by transferring every 4th proton to dark proton at flux tubes forming dark proton sequences as dark nuclei. Also, dark ions become important in biochemistry. At least positively-charged ions would have an important control role in TGD based view about biochemistry.

Realization of the vision about Magnetic Body (MB) as controller of ordinary biomatter

M8-H duality (see this) concretizes the general vision. This duality states the representability of space-times as a 4-D surfaces in either complexified M8 or H = M4 × CP2. n=heff/h0 has interpretation as

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dimetinsion of extension of rationals and would the degree of a polynomial determining the space-time surface in M8 as a root of polynomial of degree n.

Roots would correspond to different sheets of n-sheeted space-time surface and Galois group of extension would permute the sheets with each other and act as a number theoretic symmetry group. Dark matter states at the flux tubes of Bend would be in representations of Galois group and Galois confinement (see this) forcing n-particle states to behave as single unis like hadrons as color confined states.

The model of bio-harmony (see this and this) based on the icosahedral and tetrahedral geometries in turn predicts that genetic codons correspond to dark photon triplets as 3-chords of lights. The representation of 12-note scale as a sequence of quints reduced by octave equivalence fixes the harmony for a given Hamiltonian cycle and realizes the symmetries of the harmony defined by some subgroup of the icosahedral group.

Combination of 3 icosahedral harmonies with 20 chords and having different symmetries with tetrahedral harmony with 4 chords gives bioharmony 20+20+20+4=64 chords assigned to DNA codons. Amino-acids are identified as orbits of 3-chords under the symmetries of a given harmony and one obtains 20 amino acids. DNA codons coding for a given amino acid correspond to the chords at the corresponding orbit and the numbers of DNA codons coding for a given amino acid come out correctly.

Bio-harmony assigns the binary aspects of information to the 6 bits of codon and emotional aspects to the bio-harmony characterized by allowed chords fixed by a given Hamiltonian cycle at icosahedron and the unique tetrahedral cycle. The model of bio-harmony requires that the values of B end correspond to those associated with Pythagorean scale and defined by quint cycle. These frequencies would correspond to energies that a molecule must have to serve as a candidate for a basic biomolecule.

In the model of genetic code (see this) identifying codons as dark proton triplets, the numbers of dark proton triplets correspond to numbers of DNA, RNA, tRNA codons and amino acids and one obtains correctly the numbers of DNA and RNA codons assignable to given amino-acid in the vertebrate genetic code. Genes would correspond to sequences of dark proton triplets. Dark proton triplet would be analogous to the baryon and Galois confinement (see this) would force it to behave like a single quantum unit. Dark codons would in turn bind to Galois confined states of the Galois group of extension of the extension associated with the codons.

Galois confinement would be realized also for the dark photon triplets as representation of genetic codons and also for the sequences of N dark-photon representing genes as dark 3N-photon states. Genes would serve as addresses in the communications based on dark 3N-photon resonances. For communications between levels with the same value of heff, there would be both energy and frequency resonance and for levels with different values of heff only energy resonance. It is an open question whether for dark-ordinary communications dark photon 3N-plets transforms to single ordinary biophoton.

The basic hypothesis is that both DNA, RNA, tRNA, and amino acids are paired with their dark analogs, and that energy resonance mediates the interaction between the members of pairs. In this article, the goal is to clarify the dark-ordinary pairing and the interaction between the members of the pairs. To achieve this, we first propose some questions below and then synthetize the answers to them.

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Questions

In the sequel, we will address the following questions about the roles of MB in the biochemistry of the basic biomolecules.

1. Do dark protons appear already in non-organic chemistry? Does acid/base tend to give/bind with a dark proton? The basic process is OH → O- +H+. Water represents the basic example containing ions H3O+ and OH-. The dark proton from H2O would bind to the second H2O acting in the role of base. pH characterizes the fraction of protons equal to 10-7 for pH=7.

Does the transition to biochemistry mean Pollack effect (see this) in which the fraction of dark protons becomes 1/4 corresponding to pH= log10(4). This would be the case for DNA, RNA, amino-acids, and tRNA also? Are the transitions between dark and ordinary states a key element of biochemistry? Could the gravitational flux tubes of Magentic Body (MB) take an active role in biochemistry?

2. Could the proton in hydrogen bond be dark? Could length of the hydrogen bond vary corresponding to different values of heff=hgr? Could this explain the behavior of water below 100oC (in particular at physiological temperatures) challenging the standard thermodynamical model?

3. Do dark electrons play a role in chemistry as suggested (see this)? Does oxidation/reduction mean almost giving/receiving a dark valence electron in the valence bond?

REDOX reactions are central also in biochemistry. The basic example is combustion in which O= =O in presence of hydrocarbon such as sugar CnH2n gives rise to CO2 and H2O and Cn-1H2n-2. O is reduced so that it almost receives valence electrons from C and H and C and H are in turn oxidized.

The notion of electronegativity parametrizes the tendency to receive an electron. Is it possible to state that in inorganic and organic chemistry the electromagnetic part of MB is by far more important than the gravitational part of MB whereas in biochemistry also the gravitational part becomes important?

Also ions are proposed to appear as dark variants and one can wonder whether the valence electrons of positively=charged biologically important dark ions like Ca++ are actually dark.

The following question can be asked about the role of MB in biochemistry of basic biomolecules.

A. Does the energy resonance for dark proton triplets and even for their sequences between biomolecules and their dark variants select the basic biomolecules like DNA, RNA, tRNA, and amino-acids having dark proton counterparts? Base pairs in DNA double-strand involve also hydrogen bonds. Could these hydrogen bonds have also dark variants?

B. Dark proton triplets would neutralize the negative charges assignable to the phosphates of DNA and RNA nucleotides and could be imaged as coming from POH→ PO- +H+ by a transformation of proton to dark proton by the analog of Pollack effect making DNA negatively-charged.

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What about the cell membrane whose lipids have also phosphate ions at their ends? Could this give a higher level representation of the genetic code and genes at cell membrane level making possible dark 3N-photon communications between genome and cell membrae? Or do the dark protons serve at least as an energy storage? In fact, it has been proposed that cell membranes could involve a genetic code (see this).

Microtubules are accompanied by negatively-charged GTP molecules possibly associated with tubulins. 6-bit code defined also by DNA codons has been proposed by Hameroff et al as a memory code (see this). Could it be associated with genetic code represented using dark proton triplets?

C. The amino-acids in proteins should pair with dark variants of amino-acids by energy resonance. Amino-acid backbone does not, however, carry negative charge. Are the dark protons coming from NH2 and COOH neutralized by electrons so that one would have dark hydrogens?

D. Also, the ATP molecule has a negative charge of 3 units. Is it neutralized by a dark proton triplet serving as a temporary storage of metabolic energy? C ould this energy at least partially explain the somewhat questionable notion of the high energy phosphate bond (also dark valence electrons would contribute)? Could ATP→ ADP liberate metabolic energy by splitting one dark valence bond and transforming one dark proton to ordinary one? Do the dark protons assigned with the proteins serve as metabolic energy storage besides valence electrons whose reduced Coulombic binding energies also give rise to higher than expected bond energies?

See the article "TGD-based view about dark matter at the level of molecular biology".

For a summary of earlier postings, see Latest progress in TGD.

Articles and other material related to TGD.

http://matpitka.blogspot.com/2020/10/arrow-of-time-in-neuroscience-tgd-based.html

TGD-based view about the Arrow-of-Time in NeuroscienceThe question that inspired tes article of Arrow-of-Time in Neuroscience was whether memories

about the Future are possible. This requires retrocausality. The criticism of retrocausality relies on the assumption that Time (in particular the thermodynamical time) has always the same Arrow.

If one gives up this assumption, there is no reason forbidding retrocausality and phenomena like sensory perception of signals arriving from the Future giving rise to precognition. In fact, our ability to predict a lot about our Future might be due to this kind of sensory perception rather than only due to computation using a neuronal model.

There is empirical evidence for a non-standard Arrow-of-Ttime. Phase conjugate light rays (see this) obeying the Second Law in wrong time direction, Fantappie's work (see this), self-organization in biology - the self-assembly of the tobacco mosaic virus is a classical example (see this). The latest finding that I learned of is that an isolated system can extract organized energy from its thermal energy (see this).

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In the framework of Topological GeometroDynamics (TGD), Zero Energy Ontology (ZEO) (see this) leads to a quantum measurement theory solving the basic problem of standard quantum measurement theory due to the conflict between determinism of Schrödinger equation and non-determinism of quantum jump. Key prediction is that the Arrow-of-Time changes in ordinary "big" state function reduction (BSFR) whereas in "small" state function reductions (SSFR) analogous to "weak" measurements, the Arrow-of-Time is not changed.

This forces a generalization of Thermodynamics and dissipation with opposite Arrow-of-Time allows us to understand self-organization and also energy feed necessary for it in terms of a generalized Second Law. A system dissipating in non-standard time direction seems from the point-of-view of the outsider to develop structures and extract energy from the environment.

The non-standard Arrow-of-Time would be associated with the magnetic body (MB) carrying heff=nh0 phases of ordinary matter identifiable as dark matter and making it a Macroscopic quantum system for sufficiently large values of n. MB would act as master of the ordinary matter and induce effective time reversal at the level of ordinary matter in long time scales.

The TGD view about the neural system differs from the standard picture.

1. The first new element is the different role of nerve pulses. They create communication pathways along which dark photons can propagate.

2. Second new element is the presence of linear flux tube structures assignable to neural pathways assignable to linguistic cognition unstable against effective axonal splitting occurring in Alzheimer disease (AD)\citeAlz and the presence of 2- and even 3-D flux tube structures assignable to geometric and holistic cognition. This would survive in AD (see this) and in states involving cognitive defects (idiot savants). Meridian system and glial cells could relate to this aspect.

Communications in this system would be based on dark photons transforming to bio-photons and travelling along flux tubes with light velocity. This system would be the predecessor of the neural system and could be realized even in the case of plants. In the neural system, the real communications would rely on dark photons (ordinary photons with effective Planck constant heff=nh0>h).

The communication lines would be dynamical consisting of axonal flux tubes connected by nerve pulse transmission to longer structures serving as wave guides along with dark photons signals would propagate. Metabolic economy could motivate this kind of realization as for electronic communications in modern society. Nerve pulses would only build the connection lines for communications inside the brain. They would however modulate the frequency of Josephson radiation from neuronal membrane to the MB of the brain and in this manner communicate sensory data from cell membrane to MB.

According to ZEO-based theory of Consciousness causal diamond (CD) identified as CD = cd × CP2 ⊂ H = M4× CP2 where H denotes 8-D imbedding space containing space-time as 4-surface and cd is the intersection of Future and Past directed light-cones in 4-D Minkowski space M4 and CP2 is 4-D complex projective space. The passive boundary would correspond to holistic, spatial, and the “timeless” component of conscious experience dominating in meditative states and active boundary to reductionistic, temporal part of conscious experience such as

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sensory perception and cognition. These components correspond to opposite Arrows-of-Time at certain layers of MB.

4. I have considered the realization of the holistic emotional intelligence in terms of the notion of bio-harmony (see this and this). Here, one must however remember that emotions could be sensory percepts at the level of MB so that they should correspond to the dynamical aspects of consciousness rather than the permanent part. Music expresses and induces emotions and harmony codes for the emotional state.

A model involving icosahedral and tetrahedral symmetries leads to a model that Pitkänen calls bio-harmony. The model predicts correctly the basic aspects of the vertebrate genetic code. The codons would correspond to 3-chords of bio-harmony. The realization of bio-harmony is assigned with magnetic bodies of the basic biomolecules including RNA and DNA.

5. EEG frequencies f>10 Hz assigned to wake-up consciousness could correspond to the effectively 1-D and "linguistic" neural system and frequencies f<10 Hz to the system responsible for holistic aspects. During sleep, f<10 Hz dominates so that the consciousness should be holistic. Since we do not remember anything about this period, it could correspond to time-reversed mode making possible precognition as sensory perception of signals from the Geometric (relativistic) Future.

6. The effective change of the Arrow-of-Time in the neural system induced by its real change at the level of MB could mean the change of the direction of nerve pulse conduction. This reversal could explain phenomena like reverse writing and reverse speech discussed in this.

There is evidence that AD patients have precognitive and prophetic dreams (for references see the article at Research Gate). Ordinary nerve pulse conduction is prevented in AD by axonal plaque and exponentially attenuated. In the reverse time direction, there would be an exponential amplification with respect to standard direction of Time. This suggests that AD neurons are dead in standard time direction but re-incarnated in the opposite time direction. Death would be a gradual process.

The proposed hypothesis is testable. To hold true, manipulation of the level of acetylcholinesterase inhibitors (AChEIs) should reduce the formation of past event memory and increase the formation of future oriented precognitive memory traces.

Indeed, there is evidence that Rivastigmine (a reversible ACEI used in the treatment of AD) increases memory and rapid eye movement sleep and has been suggested that aside from those normal properties, it could be implicated in retrograde dream formation (i.e., precognitive dreaming; for references see the article at Research Gate). Similar pilot study has yielded same results before (for references see the article at Research Gate).

Further support comes from the bidirectional relationship between AD and sleep disorders through a model of brain rhythm attractor breakdown (for reference see the article at Research Gate). In fact, individual differences were found in prophetic dream belief and experience, with a high frequency of prophetic dream experiences associated with disordered sleep patterns and sleep medication use (for references see the article at Research Gate).

In the sequel, this picture is discussed in more detail. In particular, the question how the possibility of non-standard Arrow-of-Time could make possible precognition as sensory perception of signals from

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the Geometric Future is considered. Our ability to predict our future is usually regarded as trivial. Computationalists explain it by assuming that the brain is a computer predicting the Future. This ability could involve this sensory perception in an essential manner.

See the article "Arrow of time in Neuroscience: TGD-based view".

For a summary of earlier postings, see Latest progress in TGD.

Articles and other material related to TGD.

http://matpitka.blogspot.com/2020/10/could-i-go-to-bed-today-and-wake-up.html

Could I go to bed today and wake-up yesterday morning?In Zero Energy Ontology (ZEO), falling asleep (death at "my" level of self the hierarchy)

corresponds to ordinary - or "big" - state function reduction (BSFR) and also means a reincarnation with opposite Arrow-of-Time. We would be therefore conscious during sleep and wake-up would correspond to falling sleep of that other time-reversed self.

When I fall asleep, I wake-up later tomorrow morning for instance, not yesterday morning. It is interesting to see what kind of conditions this implies and whether it is possible to satisfy this easily and even more interesting is to see whether a time travel to the Geometric(relativistic)-Past (maybe the Golden Youth) could be possible.

The following assumptions are made about what happens in BSFR.

1. Causal diamond (CD) is a correlate for self. CD is obtained by gluing together 2 identical half-cones along their bottoms. Moment "Now" corresponds to the largest hyperplane Tnow=T (origin of time coordinate is at either (call it "lower") tip of CD) .

2. During the sequence of SSFRs defining self, the 3-surfaces at the passive boundary of self are fixed although their 4-D tangent space changes and corresponds to the unchanging part of selfhood (one might saythe soul). The opposite active boundary of CD and 3-surfaces at it change and shift towards the Geometric-Ffuture. This gives rise to wake-up consciousness involving sensory input and thoughts, emotions, etc. induced by it. Each SSFR is preceded by the analog of unitary time evolution.

3. BSFR means a death of self (subself) and its reincarnation with an opposite Arrow-of-Time. One can equally well speak about the analog of falling in sleep and waking up after that for some level of hierarchy of selves. The self born in the death of the self with an opposite Arrow-of-Time self has no direct memories about the state. Self can however have memories about dreams in which part of say brain is awake. These memories store information about what self experienced during the sleep.

In BSFR, the active boundary of the CD becomes passive and is frozen. The size of CD is scaled down so that CD becomes small. This implies that the reincarnated self has a childhood and much of the memories (often not pleasant) stored near the active boundary as subselves living forth-and-back as conscious entities disappear. The surviving memories of self become "silent wisdom" of the reincarnated self.

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4. If CD belongs to a larger CD (call it CD super representing a larger unit of consciousness), the sub-CDs must shift to the same direction as the active boundary of CDsuper. Otherwise the sub-CDs would drop from the flow of consciousness. This is analogous to co-movement of matter in Cosmology.

Note that the mental images of self correspond to sub-CDs around Tnow and shift towards Geometric-Future as CD increases and new mental images emerges at Tnow plane. By M8-H correspondence, these special moments in the life of self correspond to roots of the polynomial defining space-time surface and reside are the upper half-cone of the CD. As CD increases, new roots pop up inside the upper half-cone near the Tnow hyper-plane for some particular SSFRs.

Completely counterintuitively, the mental images about past experiences are therefore in the Geometric-Future of Tnow hyperplane!

The proposed picture must be consistent with everyday experience. Call the two periods of self sleep wake-up and sleep label the two different BSFRs by "sleep" and "wake-up".

A. In each SSFR, CD size increases at least in statistical sense (this implies that T grows). Each SSFR corresponds to a scaling for the CD shifting its active boundary towards the Geometric-Future. During its life cycle CD experiences scaling Λ:

Tnow→ Tnow,sleep1 = Λ(SSFR) Tnow , Λ(SSFR) >1 .

B. When the system falls in sleep the size of CD is scaled down so that also the value of Tnow is scaled down by ΛBSFR<1:

Tnow,sleep2 = (1- Λ(BSFR)) 2Tnow,sleep1 = (1- Λ(BSFR)) Λ(SSFR)2Tnow , Λ(BSFR)<1 .

After that the CD begins to increase in size by small scalings in SSFRs to opposite time direction and Tnow begins to decrease from its value Tnow,sleep begins to decrease.

C. If CD belongs to a bigger CD (call it super-CD - representing a larger unit of consciousness with a longer life cycle), one can argue that the CD must shift to the same direction as the larger CD increases. Otherwise the CD would drop from the flow of consciousness defined by super-CD.

This is analogous to co-movement of matter in Cosmology. Therefore a given life cycle corresponds also a shift ΔT of sub-CDs towards the growth direction of super-CD takes place and one has for the time coordinate Tsuper,now of the super-CD. One must perform shiftT→ T+ ΔT for Tnow,sleep1 and Tnow,sleep2 to take into account the drifting. This gives for the moments "Now" before ad after the shrinking of CD in BSFR (falling asleep):

Tsuper,now,sleep1 = T0 + Tnow,sleep1 +ΔT

Tsuper,now,sleep2 = T0 + (1- Λ(BSFR)) 2 Tnow,sleep1 +Δ T .

D. Similar formula holds true for the moment of wake-up. In the previous formula, T now is replaced with Tnow,sleep2 and one has

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Tsuper,now,wakeup1 = T0 + Λ1) (SSFR) Tnow,sleep2 +Δ T1)

Tsuper,now,wakeup2 = T0 + (1- Λ1) (BSFR)) Λ1) (SSFR) 2Tnow,sleep2 +Δ T1) .

The parameter T0 depends on the choice of the origin of time for super-CD but is irrelevant.

One can deduce a consistency condition for the parameters of the model.

I. During the sleep period, the time coordinate Tsuper,now for moment "Now" in the coordinates of larger CD changes in the following manner:

Tsuper,now,sleep = T0 + Tnow,sleep1 → Tsuper,now,wakeup

= T0 + Λ1) (BSFR) Tsuper,now,sleep2 + ΔT1) .

T0 is an irrelevant parameter associated with super-CD. Note that there is breaking of time-reversal symmetry since self associated with CDsuper has fixed Arrow-of-Time unlike CD. Hence ΔT has at least in a statistical sense the same sign irrespective of the Arrow-of-Time of self.

II. This picture should be consistent with what we observe. When the tired average self falls asleep at the evening, it wakes wake-up at the morning and is full of energy. Quite generally, wake-up occurs after time ΔT(sleep) meaning that the value of time Tsuper has increased by

Tsuper,now,wakeup = Tsuper,now(sleep1) + ΔT(sleep) .

These two expressions for the value of Tsuper,now(wakeup) must be consistent and this gives a conditions on the parameters involved:

(1- Λ1) (BSFR)) Λ1) (SSFR) 2Tnow,sleep1 +ΔT1)

= Tnow,sleep1 +ΔT + ΔT(sleep) .

Δ T(sleep) is given by

[(1- Λ1) (BSFR)) Λ1) (SSFR)2-1] Tnow,sleep1 +ΔT1) -Δ T .

Intuitively it seems clear that for a given Arrow-of-Time, it is not possible to wake-up before one falls asleep. The condition ΔT(sleep)>0 for the standard Arrow-of-Time gives a constraint on the parameters. One cannot, however, exclude the possibility of time-travel without dying or falling asleep first of the duration of time-travel is much longer than that of wave-up period: ΔT1) - ΔT.

A special solution corresponds to

ΔT(sleep) = ΔT1) - Δ T and (1- Λ1) (BSFR)) 2Λ1) (SSFR) = 1

giving Tnow,sleep2 = Tnow.

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For a summary of earlier postings, see Latest progress in TGD.

Articles and other material related to TGD.

http://matpitka.blogspot.com/2020/10/dna-and-time-reversal.html

DNA and Time ReversalThis posting is the introduction of the first article devoted to the view about DNA inspired by Zero

Energy Ontology (ZEO) (see this and this) forming the basis of the quantum measurement theory of Topological Geometrodynamics (TGD) and by the notion of dark DNA (see this) inspired by the TGD view about dark matter as phases of the ordinary matter with effective Planck constant heff=nh0>h (see this and this, this) at Magnetic Body [MB] (see this, this, this, and this) - the third key notion distinguishing TGD from the Standard Model of Particle Phsycis.

The basic prediction of ZEO is that "big" (ordinary) state function reduction (BSFR) changes the arrow of time meaning "death" and "reincarnation" with opposite Arrow-of-Time. For dark matter at the MB, the periods with a given Arrow-of-Time would be long and induce the long-lasting effective change of the Arrow-of-Time for the ordinary matter.

This leads to a new view about self-organization (see this) involving in an essential manner time reversed dissipation looking like energy feed in the standard direction and quantum coherent MB as a master quantum controlling the ordinary matter. The energy feed is necessary since the increase of heff

requires energy.

Time Reversal and the dynamics of DNA

The time reversals of the basic processes like transcription and replication turn out to be possible only for the conjugate strand. This is basically due to the chiral selection and CPT theorem in TGD context. CPT C denotes harge conjugation, P spatial reflection, and T geometric-time reflection to be distinguished from thermodynamical time reversal and time reversal occurring in BSFR.

The triviality of C (matter-antimatter asymmetry) implies that T acts like P mapping molecules to their mirror images. By chiral selection, enzymes can catalyze processes but not their time reversals. For instance, conjugate strand polymerizes in reverse time direction (this looks like depolymerization in the standard time direction). Polymerization of the conjugate strand, however, occurs in standard time direction but in reverse direction along the strand.

The recombination of DNA strands during meiosis is poorly understood. This could correspond to reconnections for the magnetic flux tubes associated with the active DNA strands. Time Reversal would occur in BSFR and formerly passive conjugate DNA strands would depolymerize to "loose" codons (see this) (not independent letters) by the time reversed polymerization. The flux tubes associated with the formerly active strands would suffer reconnections inducing recombination without assistance of enzymes, second BSFR would occur, and be followed by the replication of recombined active strands.

Does DNA have longitudinal electric field with direction correlating with the Arrow of Time?

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According to the findings of Becker, the direction of the electric along the body axis field determines whether the system is awake or asleep. By the properties of electric field under time reflection, the Arrow-of-Time correlates also with the direction of the electric field. TGD predicts that Consciousness is possible even at the level of DNA. Could also DNA have a longitudinal electric field with direction correlating with the Arrow-of-Time of DNA at the MB of DNA? Could there be a switch changing the direction of this electric field?

There is an inspiring analogy with microtubules which are highly dynamical and carry a longitudinal electric field whose strength correlates with the microtubule length (see this). Could sticky ends generate a longitudinal field along DNA double strand with strength determined by the lengths of the sticky ends?

In the Standard picture, the flux of the longitudinal electric field would be proportional to the difference of the negative charges associated with the sticky ends. In TGD framework, DNA strands are accompanied by the dark analog of DNA with codons realized as 3-proton units neutralizing the negative charge of the ordinary DNA except at sticky ends.

A simple proposal for the time switch based on the analog of Becker's DC currents emerges. Proton flow of the dark protons between sticky ends would change the Arrow-of-Time. The model could generalize also to proteins known to be ferro-electrets and accompanied also by their dark analogs.

See the article "DNA and Time reversal".

For a summary of earlier postings, see Latest progress in TGD.

Articles and other material related to TGD.

http://matpitka.blogspot.com/2020/10/about-role-of-possible-longitudinal.html

About the role of possible longitudinal electric field of DNAThe motivation for this second article discussing DNA and the Arrow-of-Time was the question

whether there could be a longitudinal electric field associated with DNA and whether the reduction of its strength could serve as a bioelectric marker of cancer, aging, and death. This could be the case if the length of DNA correlates with the strength of this electric field. The natural question is whether the length of the negatively-charged sticky end of DNA could determine the strength of this electric field.

Could DNA be a ferroelectret and could the length of sticky ends control the strength of the longitudinal electric field?

DNAs and RNAs are bioelectrets (see this and this) but the question whether they are bioferroelectrets (see this) possessing a constant longitudinal electric field in the absence of external electric field is an open question.

Telomeres are associated with the ends of DNA double strands. The lengths of telomeres (see this) are controlled by the telomerase enzyme. The shortening of telomeres is known to relate to aging. For cancer cells, germ cells, and stem cells, the length of the telomeres is not varying. In cancer, their lengths are abnormally short.

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Telomeres could act as buffers shielding the part of DNA coding for proteins. Telomeres have "sticky ends" assignable only to the second DNA strand and carrying negative charge. What could their function be? Could telomere lengths correlate with the lengths of the sticky ends and what could control their lengths?

There is an analogy with microtubules which are highly dynamical and carry a longitudinal electric field whose strength correlates with the microtubule length. Could the sticky ends (see this) generate a longitudinal field along DNA double strand with strength determined by the lengths of the sticky ends?

In the Standard picture, the flux of the longitudinal electric field would be proportional to the difference of the negative charges associated with the sticky ends. In a conceptual framework based on Topological GeometroDynamics (TGD) which is a proposal for a unification of fundamental interactions inspiring a vision about Consciousness and Quantum Biology, DNA strands are accompanied by the dark analog of DNA with codons realized as 3-proton units neutralizing the negative charge of ordinary DNA except at sticky ends.

If the dark double strand also accompanies the sticky end, the total charge is positive. If not, it is negative. This allows to consider the possibility that opposite sticky ends have opposite charges so that there is a long dipole-like entity carrying longitudinal electric flux proportional to the common length of sticky ends.

Experimental signatures

Also in the Standard physics-based picture (i.e., no dark DNA), an external electric field created by the polarization of the nucleotides A, T, C, G in an external electric field is possible (see this). This would mean electrect property (not yet ferro-electricity). T he model for the phenomenon suggests that ferro-electricity could result in the sense that the polarization is non-vanishing also in absence of the external electric field so that the nucleotide (rather than entire DNA strand) would be an electric analog of ferromagnet.

In this case, the behavior in the external electric field is different from that for ferro-electric DNA double strand. DNA double strand itself would not experience a direct torque in the external electric field. The effective polarization per nucleotide predicted by TGD is at least by a factor 2.5-7.5 stronger than the Sandard Model polarizations so that the model can be tested. Furthermore, ferro-electricity of DNA in the TGD sense requires DNA double strands and would be present for single DNA strand.

The secod testable prediction is the possibility of currents running along DNA double strand in the longitudinal electric field even without external electric field. External field would, however, add to the ferroelectric field of oriented DNA double strands and lead to an anomalously high conductivity.

Another test would be based on the ferro-electret property of Living tissues which could be caused both by DNA and protein ferro-electricity. Living tissues are indeed known that be ferro-electres as the phenomena of pyroelectricity, piezoelectrity (studied first by Ahlenstaedt (see this), and the polarization in an external electric field demonstrate. Ahlenstaedt proposed that the permanent dipole-like character (ferroelectricity) of the linear biomolecules gives rise to their bioferroelectricity.

connection with Consciousness

An analogy with the findings of Becker about the electric fields along the body axis emerges. Becker found that the direction of this field determines whether the organism is awake or in a sleep state. The weakening of these fields leads to aloss of consciousness. TGD-inspired theory of

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Consciousness predicts that even sysems like DNA can be conscious. The fractality of the TGD Universe suggests that the physical correlates of consciousness are same in all scales.

Could the direction and strength of the electric field of DNA correlate with consciousness at this level? In TGD-based quantum measurement theory extending to a theory of Consciousness, the Arrow-of-Time changes in "big" state function reductions (BSFRs) which mean "death" and "reincarnation" with opposite Arrow-of-Time (see this). By the tensorial properies of electromagnetic field tenso,r the Arrow-of-Time correlates also with the direction of the electric field. This leads us to ask whether the change of the Arrow-of-Time in BSFR could change the direction of the DNA's bioelectric field? One ends up with a simple mechanism for this based on the analog of Becker's DC currents along DNA as proton currents.

Telomore length, Cancer, and DNA ferroelectricity

Compelling evidence suggest that there is an inverse relationship between telomere length and both different types of cancer incidence and mortality (references in article) suggesting that the control of telomere length by telomerase enzyme is impaired (references in article).

Almost in all cancer cells, telomere length is shortened (references in article). Telomere shortening accompanies ageing (references in article). Even in stem cells (except for embryonic stem cells and cancer stem cells), there are overwhelming evidence that telomere shortening occurs during replicative ageing, though at a lower rate than that in normal somatic cells (references in article).

In this picture, the simplest possibility is that telomeres act as buffers. The strength of the longitudinal electric field controlled by the length of sticky ends controls the length of telomeres and thus of DNA. Sticky ends would be the key control knobs used by telomerase enzyme. The Magnetic Body (MB) of the system would be the ultimate controller.

Apart from some exceptions, telomere length in DNA is shortened in almost all cell types during aging and some diseases based on the level of telomerase activity or its absence. Ageing could be purposefully induced since Eternal Life would be a metabolic catastrophe from the perspective of population overgrowth and evolution (reference in article).

This motivated us to propose the hypothesis that DNA bioelectricity changes over time and depends on disease progression and severity. This provides an excellent opportunity to establish novel predictive, prognostic and therapeutic biomarkers differentially in different cell types or as a combined bioelectric marker for "whole-body" as a derivation of mathematical formulations. This hypothesis is necessary for designing tailor-made microelectrochemical impedance spectroscopy technologies, and consequently pilot studies designed a priori are needed to test our hypothesis.

Along with replication of well-designed pilot study with a more diverse population and larger sample size, it will be needed to address questions about cut-offs or personalized normal ranges for differential and mean whole-body DNA's bioelectric field in a longitudinal study in a prospective manner. With this brief background, the aim of this paper is to suggest DNA's bioelectric field as a novel bioelectric marker to be used for prognostic and diagnostic purposes in researches of cancer, aging, surgery grafts, and rejuvenation for the first time.

See the article "DNA's bioelectric field an early bioelectric marker of cancer aging and death a working hypothesis".

For a summary of earlier postings, see Latest progress in TGD.17

Articles and other material related to TGD.

http://matpitka.blogspot.com/2020/10/new-physics-view-about-language.html

New Physics View about LanguageHuman languages differ dramatically from their analogs for animals. Animal languages consist

mainly of simple signals, warnings and threats for instance. Emotional expression dominates and grammar is lacking. Birds can have impressive repertoire of different song patterns and monkeys have gesture language.

There is a huge variety of human languages: speech and written language, sign languages based on gestures, the language of mathematics and computer languages in which emotional expression is absent. One can also regard music as a kind language expressing emotions and creating them.

Also, pictures define linguistic representations. Children and animals learn language by mimicry and also learn the grammar and syntax without conscious efforts. Adults can learn a foreign language by learning the vocabulary and the rules of grammar.

Human language is also special in that it involves conceptualization, metaphors, and analogies representing abstract concepts in terms of objects and actions of the external World.

One might understand the semantic aspect of language in terms of association and conditioning. Language acquisition involves showing an object and uttering the word(s) describing it or assigned to it. This suggests that conditioning and association happens so that mere word generates an imagined percept of the object. Conditioning and formation of associations is a very general form of learning assumed to relate to the increase of synaptic strengths leading to a generation of association pathways. In computer science, pattern recognition and completion models it mathematically. One one can ask whether learning of language and language understanding is something more than this.

For more detailed approaches of language theories, interested readers may be referred to references (see this and references in the article). The article of Kempe and Brooks (see this) and the review article "From Molecule to Metaphor: A neural theory of language" about the language theory of Jerome A. Feldman by Stefan Frank (see this) gives a deeper perspective to language theories. The notion of embodiment is in key role in these theories and will be in a key role also in the proposal to be discussed.

About language genes

Forkhead box protein P2 (FOXP2) encodes a transcription factor involved in language acquisition and speech (see this). In addition to FOXP2, a limited number of genes are involved in speaking (see this).

All vertebrates possess FOXP2. However, it is estimated that some 120,000-200,000 thousand years ago, some mutations occurred only in humans which aided humans to start initial forms of speaking (reference in article). Animals have their own primitive language. Both voices and gestures with meaning make communications possible. They mainly recognize each other and communicate with pheromones.

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As for vocabulary, a short review of the Old Testament, cuneiform writings, glossary of old books, and hieroglyphs clearly shows that the number of entries was quite limited in the past. Therefore, a further progression of language could be mostly a matter of cultural communications and technological advances.

However, today it is clear that crucial mutations occurred in the non-coding part of the genome controlling the expression of genes coding for proteins (see this) which lead to language evolution. Therefore, the evolutionary step was associated with control of existing genes. Humans are also distinguished from animals by their learning abilities.

Language acquisition must rely on conditioning/associations between language expressions and experiences. It seems that embodiment is the mechanism which associates to a linguistic expression an imagined sensory perceipt and/or motor action making the emergence of meaning. What is needed is long term memory and also some kind of standardization of percepts so that they consist of standardized mental images. Pattern recognition and completion could give this standardization.

Since sensory and motor imagination could be seen as almost sensory experiences and motor actions, th is suggests that new communications between auditory organs and sensory and motor areas emerged. Even more generally, this kind of communication could have emerged quite generally. This would be essentially a new form of conditioning and the same mechanism could apply to all kinds of conditionings.

How the mutation of only a few genes led to cultural evolution

Amazingly, only a few mutations for relatively few genes seems so have led to human languages. Why few point mutations of relatively few genes could have transformed biological evolution to cultural evolution? What happened for these genes? In the biochemistry framework, it is difficult to imagine an answer to this question. Here, TGD-physics could come to rescue.

Number theoretic physics is part of Quantum-TGD and essential for understanding evolution as an increase of algebraic complexity. Evolutionary hierarchies would correspond to hierarchies of algebraic extensions of rationals. The dimension n of extension defines effective Planck constant heff/h0=n. The larger the dimension, the larger the scale of quantum coherence at corresponding level of the Magnetic Body (MB) associated with the system.

One can also say that n is analog of IQ. One can assign a value of h eff characterizing their evolutionary level also to genes. The genes with larger heff would serve as control genes. The increase of heff for genes would mean an evolutionary step. Perhaps a dramatic increase of h eff occurred to FOXP2 and some other genes as human language emerged.

Second mechanism could be energy resonance in the coupling of the analogs of DNA, RNA, tRNA, and amino acids consisting of dark proton triplet with their chemical counterparts. The coupling would be between the entire gene and its dark analog and codon sequence would play a role of address. In both cases, small changes of the gene could spoil or produce an energy resonance. This sensitivity would make genes an ideal control tool but would also serve as a general mechanism also for genetic diseases. The increase of heff accompanied by a small mutation to guarantee energy resonance could be the mechanism explaining the importance of FOXP2 and similar control genes.

See the articles "New Physics View about Language: Part I" and "New Physics View about Language: Part II".

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For a summary of earlier postings, see Latest progress in TGD.

Articles and other material related to TGD.

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