oncoprime - patient derived platform for biologics research
TRANSCRIPT
A bio-better, with substantive benefits to patients in the form
of faster action, lower dosing, different form of delivery or a
better side effect profile offers a very valuable commercial
opportunity. Development of bio-betters is less risky vis-à-vis
novel biologics because they build on already-validated
targets while still offering the advantage of patentability and
increased profitability vis-a-vis bio-similars. Hence many
bio-similar players are also evaluating their molecules for
bio-better potential.
Some strategies currently in use for bio-better development
include chemical modifications, PEGylation, glycosylation,
altered formulation, controlled release to claim benefits as
mentioned above. E.g. Altered glycosylation pattern has been
demonstrated to affect half-life (PK) and immunogenicity in
the patient, as well as binding affinity, activity and stability in
the case of TrastuzuMab (TrasGex).
Characterization of bio-similars/bio-betters with cytotoxicity /
proliferation assays, receptor binding/target displacement
assays and mechanism of action assays are routinely
performed using cell lines that may have been misidentified
and / or have aberrant pathways that are not representative
of the clinical setting.
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SAARUMSCIENCES
Phenotypic Platforms for Drug & Biomarker Discovery
Di�erentiate your bio-similars to bio-bettersusing patient-derived primary cells ! A case study to showcase the bene�ts of our phenotypic drug discovery platform
Use to profile your bio-similar / bio-better on any type of primary cells...OncoPrimeTM“
OncoPrime™ platform uses patient-derived primary samples that offer clinically-relevant genotypic and phenotypic diversity that translates better to the clinic vis-à-vis cell lines. Functional assays, when adapted to OncoPrime™ can not only help in claiming physiological relevance but also add additional layers of information for more informed clinical trials.
Correspondence:
Sreevatsa Natarajan, Co-Founder & CEO
Saarum Sciences Pvt. Ltd.,
1st Floor, AIMSR Building, Apollo Health City,
Jubilee Hills, Hyderabad 500096, India.
All Rights Reserved | Saarum Sciences | Phone: +91-9704600283, +91-40-20084362 | Email: [email protected] | Website: http://www.saarum.com
Breast cancer patient samples with various genotypes (including several TNBCs) are available as optimized cultures in 2D & mammosphere formats
Can also be tested on NSCLC patient samples to expand indication.
Patient samples with different grades of glioma available as optimized cultures in 2D & Neurosphere formats.
Can also be tested on CRC / NSCLC patient samples to expand indication
Can be tested on relevant patient samples from rheumatoid arthritis, psoriatic arthritis, psoriasis and other immune-inflammation pathologies.
OncoPrime™ platform encompasses several cancer types with varied genotypes and phenotypes that can be offered for testing various cancer therapies
Herceptin (Trastuzumab)
Avastin (Bevacizumab)
Humira (Adalimumab)
Remicade (Infliximab)
Cancer Targeted Mabs and Non-Mabs
Examples of leveraging the OncoPrime™ platformProduct or product class
Table 1. Some examples of the OncoPrime™ platform that cater to bio-better characterization
TNBC – Triple negative breast cancer; CRC- colorectal cancer, NSCLC – Non small cell lung carcinoma
SAARUMSCIENCES
Phenotypic Platforms for Drug & Biomarker Discovery
Get more from your pre-clinical characterization! Move to the clinic more informed … An infographic to highlight the utility & features of our phenotypic drug discovery platform
Page 2All Rights Reserved | Saarum Sciences | Phone: +91-9704600283, +91-40-20084362 | Email: [email protected] | Website: http://www.saarum.com
OncoPrimeTM
Develop scientific rationale for alternativeindications
using patient derived cancer cells of different origins.
Develop MOA assays to be able to EXTRAPOLATE
the use of your molecule for various
indications e.g. Trastuzumab for
Breast cancer & Lung cancer
Test your molecules on the diverse primary
cancer samples as would be seen in the clinic !
Use this data to better predict clinical PK behavior
of your molecule vis-a-vis comparator even
before you move into the clinic.
Using assays with diseased cells
will provide relevant information
on binding,
immune cell recruitment,
ADCC / CDC
and other mechanism of actions
vis-à-vis comparator
but in a clinically relevant context !
Assess if your drug candidate offers a
differential activity advantage.
Test your molecule for radiation sensitivity
/ sensitization, activity against cancer
stem cells, chemo-resistance,
synergy with other SOC drugs,
anti-metastatic activity etc.
Determine your molecules’ cytotoxicity
on patient-derived primary vs
normal samples for more
accurate & clinically meaningful
selectivity, safety and
therapeutic window
assessments.
Alternative pathways that inhibit or
substantiate effectiveness can be
investigated more effectively prior to
entering the clinic.
e.g., Assessment of reduced Trastuzumab
activity against patient samples harboring
a PTEN mutation (loss of function).
Accurate efficacy / Half Life Assessment
Use the platform
to repurpose your
exsiting pipeline
Accelerate your
preclinical
development
DrugRepurposing
Better Clinical Positioning
Better Selectivity against Clinically Relevant Mutations
Accurate Therapeutic Window Assessment
Use our platform to ID novel targets
& accelerate the discovery phase
Use our platform for validating
your novel targeted therapies
Target Identification& Validation
Accurate Pharmacokinetic Predictions
Assays for Alternative Indications