NEW FROM SINAUER ASSOCIATES

ABOUT THE AUTHORS. Marc Breedlove, the Barnett Rosenberg Professor of Neuroscience at Michigan State University, has written over 130 scienti�c articles investigating the role of hormones in shaping the developing and adult nervous system, publishing in journals including Science, Nature, Nature Neuroscience, and the Proceedings of the National Academy of Science. He is also passionate about teaching—in the classroom, and in the greater community through interviews with the Washington Post, Los Angeles Times, New York Times, and News-week, as well as broadcast programs such as All �ings Considered, Good Morning America, and Sixty Minutes. He has active grant support from the National Institute of Neurologi-cal Disorders and Stroke and the National Institute of Mental Health. Dr. Breedlove is a Fellow of the American Association for the Advancement of Science and the Association for Psychological Science.

ABOUT THE BOOKFoundations of Neural Development is a textbook written in a conver-sational style with topics appro-priate for an undergraduate au-dience. Each chapter begins with a thought-provoking vignette, or a “real-life story,” that the subsequent material illuminates.

�e “Researchers at Work” feature, available in every chapter, describes a classic study in detail, taking the reader through the hypothesis, test, result, and conclusion of an experiment. A marginal glossary, review questions, and bulleted summary are a few of the other features in the book. Despite the reader-friendly features, the book is comprehensive in scope. Chapters 1–7 unfold in the order of ontogeny, covering induction, the estab-lishment of a body plan, neural migration, di�erentiation, axonal path�nding, synapse formation, and apoptosis. Chapters 8–10 address activity-guided, experience-guided, and socially guided neural development—mechanisms that were crucial for the evolution of the human brain. Lively and engaging, with the �nest illustrations, Foundations of Neural Development is the perfect book to help any undergraduate student understand how a single microscopic cell, a human zygote, can develop into the most complex machine on earth, the brain.

February 2017 • 380 pages (est.) • 300 illustrations (est.)ISBN 978-1-60535-579-5 • casebound$99.95 Suggested list price • $79.96 Net price to resellers

FOUNDATIONS OF NEURAL DEVELOPMENTS. Marc Breedlove

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FOR THE STUDENT

Companion Website (sites.sinauer.com/fond)

�e Foundations of Neural Development Companion Website contains a range of media and review resourc-es to help students learn the material presented in each chapter of the textbook and to visualize some of the key processes discussed. �e site includes the following resources:• Chapter outlines• Chapter summaries• Animations: Detailed animations that cover some

of the key processes presented in the textbook.

• Videos: Links to fascinating videos that demonstrate the processes and concepts of neural development.

• Flashcards: An easy way for students to learn and review the key terms introduced in each chapter.

• Glossary• News Feed: A continuously updated feed of links to

science news articles relevant to neural development.

MEDIA AND SUPPLEMENTS to accompany Foundations of Neural Development

To request an examination copy, visit our website: sinauer.com

FOR THE INSTRUCTOR

Instructor’s Resource Library

�e Foundations of Neural Development Instructor’s Resource Library (available to quali�ed adopters) includes a variety of resources to aid you in the development of your course and the assessment of your students. �e IRL includes the following:• Textbook Figures & Tables: All of the �gures (including photos)

and tables from the textbook are provided as JPEGs, all optimized for use in presentations. Complex �gures are provided in both whole and split versions.

• PowerPoint Presentations: A PowerPoint presentation containing all �gures and tables, with titles and full captions, is provided for each chapter.

• Videos: A collection of fascinating segments from BBC programs that illustrate important concepts from the textbook.

• Test Bank: �e Test Bank consists of a range of questions covering key facts and concepts in each chapter. Multiple-choice and short-an-swer questions are included, and all questions are ranked according to Bloom’s Taxonomy and referenced to speci�c textbook sections.

• Computerized Test Bank: �e Test Bank is provided in Black-board’s Diploma format (software included). Diploma makes it easy to assemble quizzes and exams from any combination of publish-er-provided questions and instructor-created questions. In addition, quizzes and exams can be exported for import into many di�erent course management systems, such as Blackboard and Moodle.

• Course Management System Support: �e Test Bank is also pro-vided in Blackboard format, for easy import into campus Blackboard systems. In addition, using the Computerized Test Bank, instructors can easily create and export quizzes and exams (or the entire test bank) for import into other course management systems, including Moodle, Canvas, and Desire2Learn/Brightspace.

Prologue: The Rationalist Philosophers• All I Know Is That I Know Nothing• The Benefits of Having an Immortal Soul• What Does All This Philosophy Stuff Have To

Do with This Book?

1. The Metazoans’ Dilemma: Cell Differentiation and Neural Induction

• Metazoans Evolved the Ability to Produce Cells with Very Different Functions

• Preformationism Offered an Easy but Wrong Solution, While Epigenesis Seemed Incomprehensible

• The Rediscovery of Genes Set the Stage for Understanding Development

• Gene Expression Directs Cell Differentiation• Researchers at Work: Do Differentiating

Cells Dispose of Unused Genes?• Scientists Domesticated a Simple Worm to

Address the Questions of Cell Differentiation• Mitotic Lineage Guides Cell Differentiation

in Worms• Embryonic Development Begins by Forming

Three Distinct Germ Layers• The Vertebrate Nervous System Begins as

a Simple Tube• Many Embryos, Including All Vertebrates,

Display “Self-Regulation”• Self-Regulation Seems Incompatible with

Mitotic Lineage-Directed Differentiation• Experimental Embryology Revealed Inductive

Processes Underlying Self-Regulation• A Region of the Vertebrate Embryo Seems to

“Organize” Development• Researchers at Work: The Dorsal Lip of the

Blastopore Can Organize a New Individual• Long Abandoned, the Organizer Was

Uncovered through Molecular Biological Techniques

• Researchers at Work: A Gene Is Discovered That Acts as an Organizer

• What Organizes the Organizer?• In Insects, Epidermal Cells Compete to

Become Neuroblasts

2. Coordinating Fates: Development of a Body Pattern

• Darwin Noted that Vertebrate Embryos Start Off Looking Alike

• Mother Knows Best: Maternal Factors Establish a Basic Polarity of the Body

• Researchers at Work: Two Heads Are Not Better Than One

• A Cascade of Gene Regulatory Proteins Organizes a Body Plan

• Some Mutations in Drosophila Transform Body Parts Whole

• Hox Genes Are Crucial for Vertebrate Development, Too

• Hox Genes Direct “Segmentation” in the Mammalian Brain

• Hindbrain Rhombomere Fates Are Directed by Homeobox Genes

• Several Signals Designate the Caudal End of the Body and Nervous System

• Continued Gradients in BMP Signaling Establish the Dorsal-Ventral Axis in the Nervous System

• Researchers at Work: What Notochord Factor Induces the Floor Plate and Motor Neurons?

• Find Out Where You Are to Coordinate Your Fate with That of Your Neighbors

3. Upward Mobility: Neurogenesis and Migration

• The Same Gene May Play a Role in Many Different Developmental Events

FOUNDATIONS OF NEURAL DEVELOPMENT CONTENTS & FEATURES

Each chapter opens with a vignette, provid-ing a human context to generate interest in the science that the subsequent material illuminates.

VIGNETTE

A brief overview of the content to come, the Preview will prepare students for what they are about to learn.

PREVIEW

• The Developing Brain Generates Neurons at a Tremendous Rate

• Shortly after Division, Neural Cells Diverge to Become Neurons or Glia

• Researchers at Work: Labeling of Dividing Cells Disputes the Idea That Lineage Determines Fate

• The Cerebellum and Cerebral Cortex Form in Layers

• We Can Label Newly Synthesized DNA to Determine the Birthdates of Cells

• Newborn Cells Shinny Up Glial Poles• Researchers at Work: The Cortex Develops

in an Inside-Out Manner• A Few Brain Regions Display Continuing

Neurogenesis throughout Life• Neural Crest Cells Migrate to Positions

throughout the Body• Cell Adhesion Molecules Attract and Repel

Migrating Cells

• Cerebellar Granule Cells Parachute Down from Above

• Researchers at Work: Weaver Neurons Fail to Grasp Glial Fibers

• Cells Crucial for Smell and Reproduction Migrate into the Embryonic Brain

4. Seeking Identity: Neural Differentiation

• The Fruit Fly Retina Develops through an Orderly Progression of Gene Expression and Signaling

• Several Factors Influence Whether a Cell Will Become a Neuron or a Glia

• The Molecular Differentiation of Motor Neurons Is Orderly

• Neural Crest Cells Are Affected by Their Migration and Destination

• Researchers at Work: Neural Crest Cells Adopt New Fates after Transplantation

• The Neurotransmitter Phenotypes of Autonomic Neurons Are Guided by Their Targets

• Researchers at Work: Targets Can Regulate the Neurotransmitter Phenotype of Afferents

• The Fate of a Cortical Neuron Is Influenced Both before and after Migration

• Researchers at Work: Cortical Neuron Fate Is Specified after the S Phase

• Later Events in Development Are More Evolutionarily Labile

5. Feeling One’s Way: Axonal Pathfinding

• Ramón y Cajal Described Growth Cones and Discerned Their Significance

• In Vitro Approaches Reveal Principles of Axonal Growth and Adhesion

• Researchers at Work: Getting a Grip: The Role of Adhesion in Axonal Growth

• Guidance Cues May Be Attractive to One Type of Growth Cone and Repulsive to Others

• Families of Receptors Offer a Multitude of Guidance Cues

• Pioneer Neurons and Guidepost Cells Establish Pathways for Later Axons

• Many Axonal Growth Cones Have to Deal with Crossing the Midline

• Researchers at Work: What Makes the Floor Plate So Attractive?

• Motor Neuronal Axons Must Find the Correct Target Muscles

• Researchers at Work: Can You Navigate Your Way Home?

• The Axons of Retinal Ganglion Cells Must Reach the Midbrain

• Researchers at Work: I’d Rather Walk over Here

• The Corpus Callosum Is Directed across the Midline by a Glial Bridge

• Researchers at Work: Glia Can Help Axons Cross a Border

The figures are clearly drawn to aid students’ understanding of biological processes. Concisely labeled and explained, the figures are one of the strongest pedagogical features in the text.

COLOR ART

6. Making Connections: Synapse Formation and Maturation

• Calcium Regulators and Environmental Sensors Evolved to Mediate Synaptic Signaling

• We Can Divide Synapse Structure and Development into Three Parts

• A Synapse Begins with Adhesion• Researchers at Work: Dendritic Spines

Compete for Survival• Fragile X Syndrome Suggests There Can Be

Too Much of a Good Thing• Pre- and Postsynaptic Partners Tightly Anchor

One Another as a Synapse Develops• Researchers at Work: Presynaptic and

Postsynaptic Receptors Trigger Synaptic Development

• Neuromuscular Junctions Illustrate That Synapse Formation Is a Dance for Two (or More)

• Motor Neuronal Agrin Promotes the Aggregation of Acetylcholine Receptors

• Neuregulins Boost Local AChR Expression in Muscle and Maintain Terminal Schwann Cells

• Once Formed, the NMJ Leaves an Imprint in the Extracellular Matrix

• Researchers at Work: Neuromuscular Junctions Leave a Residue in the Basal Lamina

• Ion Channels Change Subunits, and Therefore Characteristics, during Development

• Embryonic Synapses Are Sluggish and Slow, Then Become Progressively Faster with Development

• Myelination Extends into Adulthood to Hasten Neuronal Communication

• Myelinating Glia May Prevent Regeneration in the Central Nervous System

7. Accepting Mortality: Apoptosis• The Death of Many Cells Is a Normal Process

in Development• The Extent of Death among Developing Motor

Neurons Is Regulated by the Size of the Target• Researchers at Work: Adding to the Periphery

Prevents Apoptosis of Motor Neurons• Nerve Growth Factor (NGF) Is Discovered to

Regulate Apoptosis in Sensory Neurons• Researchers at Work: Screening for Nerve

Growth Factor• NGF Has Both Tropic and Trophic Effects on

Selective Neuronal Populations• The Search for Relatives of NGF Reveals

a Family of Neurotrophic Factors and Their Receptors

• Studies in C. elegans Provide Crucial Information about the Process of Apoptosis

• Researchers at Work: It Was Suicide, Not Murder

• Apoptosis Involves Active Self-Destruction through a Cascade of “Death Genes”

• Do Motor Neurons Die in ALS for Lack of Neurotrophic Factor(s)?

• Hormones Direct Sexual Differentiation of the Vertebrate Body and Behavior

• Researchers at Work: Early Exposure to Androgens Organizes the Male Brain

• The Brain Is Also Sexually Dimorphic• Hormones Can Regulate Apoptosis to

Masculinize the Vertebrate Brain• Researchers at Work: Sometimes the Tail

Wags the Dog• Sexual Differentiation in Flies Is a Cell-

Autonomous Process• Researchers at Work: Fruitless Mutants

Pursue Unrequited Love• The Controversy over Sexual Orientation

in Flies, Rats, and People

Interlude: The Empiricists Strike Back• The Tabula Rasa and the Importance of

Experience through the Senses• What Does All This Philosophy Stuff Have

To Do with This Book?

8. Synaptic Plasticity: Activity-Guided Neural Development

• Motor Neuronal Death Is Gated by Neuronal Activity

• Developing Muscle Fibers Start Off with Polyneuronal Innervation

• Autonomic Neurons Refine Their Inputs and Outputs

• Donald Hebb Speculated about Neural Plasticity• Long-Term Potentiation (LTP) Reveals the

Existence of Hebbian Synapses• Researchers at Work: Cells That Fire Together

Wire Together• A Class of Glutamate Receptors Enforces

Hebbian Rules• The Brain Must Integrate Input from the

Two Eyes• Even Spontaneous, Apparently Random Activity

Can Provide Order• Researchers at Work: Spontaneous Waves

of Retinal Activity Form Ocular Dominance Bands in the LGN

• The Gray Matter of Human Cortex Thins as We Mature

Quotes taken from the text emphasize and reinforce key points.

MARGINAL QUOTES

Bold-faced terms are defined in the margins of the text to help students identify and learn key terminology as they read.

MARGINAL GLOSSARY

At the end of each section are review questions to help students organize and rehearse what they’ve learned from the text.

“HOW’S IT GOING?” QUESTIONS

Each section is numbered, to make it easier for in-structors to assign sections of the text, and to help students remember where content can be found.

NUMBERED HEADS

9. Fine-Tuning Sensory Systems: Expe-rience-Guided Neural Development

• Humans Can Adapt to Seeing the World in a New Way

• Retinal Ganglion Cells in Adult Amphibians and Fish Can Reestablish Connections to the Tectum

• Various Permutations of Retinotectal Regeneration Refute a Strict Version of Chemoaffinity

• Visual Experience Fine-Tunes Frog Retinotectal Connections

• Researchers at Work: Three-Eyed Frogs Show Us the Way

• Mammals Require Visual Experience during a Sensitive Period to Develop Functional Vision

• Physiological Recordings Reveal How Visual Deprivation Impairs Sight

• Researchers at Work: Strabismus in Kittens Drastically Alters Visual System Connections

• Owls Can Use Visual Experience to Fine-Tune Their Auditory Maps

• Olfactory Receptor Maps Are Also Sculpted by Experience

• Tactile Experience Guides the Formation of Topographic Maps in Somatosensory Cortex

10. Maximizing Fitness: Socially Guid-ed Neural Development

• The Terms Instinct and Innate Are So Vague That They Are Worthless

• Species with Parental Behavior Develop the Most Complex Brains and Behavior

• Maternal Behavior Can Regulate the Stress Response of Offspring

• Many Species Look to Their Parents to Recognize Mating Partners

• Observational Learning Can Transmit Behaviors across Generations

• Birdsong Is a Learned Behavior Where Young Males Model Their Father’s Song

• Researchers at Work: Sparrows Are Predisposed to Learn Species-Specific Song Elements

• Humans Are Predisposed to Learn Language without Any Formal Training

• Researchers at Work: The Habituation Response Allows Us to Read Babies’ Minds

• Primates Require Love to Develop Properly• Postnatal Social Stimulation Continues to

Affect Brain Development• Researchers at Work: Social Stimulation

Alters Neuregulin Signaling to Promote Myelination

• Intelligence Tests Demonstrate the Pervasive Effects of Culture

• The Controversial Issue of Racial Differences in Average IQ Performance

• Researchers at Work: Does Race Affect the IQ of German Offspring of American GIs?

Epilogue: Immanuel Kant and the Critique of Pure Reason• The A Priori Embodiment of Time and Space• What Does All This Philosophy Stuff Have To

Do with This Book?

Appendix: Molecular Biology: Basic Concepts and Important Techniques• Genes Carry Information That Encodes the

Synthesis of Proteins• Molecular Biologists Have Craftily Enslaved

Microorganisms and Enzymes• Gene Editing Enables the Creation of

Model Organisms

To request an examination copy, visit our website: sinauer.com

Important classic discov-eries are explained and illustrated to highlight the process of experimentation and hypothesis testing.

RESEARCHERS AT WORK

Boxes describe interesting applications, import-ant methods, sidelights, historical perspectives, or refreshers on theoretical

BOXES

Just publishedBehavioral Neuroscience, Eighth EditionS. Marc Breedlove and Neil V. Watson

Retitled to re�ect the evolution of both the book and the �eld, the Eighth Edition of Behavioral Neuro-science (formerly Biological Psychology) o�ers a broad perspective, encompass-ing cutting-edge neuroscience, lucid descriptions of behavior, evolutionary and developmental perspectives, and clinical applications of research.

2017 • 644 pages • 540 illustrations ISBN 978-1-60535-418-7 • casebound Suggested list price $157.95 Net price to resellers $126.36

Just publishedAn Introduction to Behavioral Endocrinology, Fifth EditionRandy J. Nelson and Lance J. Kriegsfeld

An Introduction to Behavioral Endocrinology, Fifth Edition provides an updated, integrated presentation of the study of hormone–behavior–brain interactions. New coauthor Lance Kriegsfeld brings additional expertise and teaching experience in behavioral endocrinology. Also new to this edition are learning objectives, set out at the beginning of each chapter.

2017 • 722 pages • 458 illustrations ISBN 978-1-60535-320-3 • casebound Suggested list price $129.95 Net price to resellers $103.96

Coming soonDiagnosing Psychiatric and Neuropsychiatric Diseases via Great LiteratureEric L. Altschuler

�is book examines prominent individuals from great literature, most-ly protagonists and a few bit players, their apparent mental disorder or disease, how those disorders and diseases meet the DSM-5 (Diagnostic and Statistical Manual-5) diagnostic criteria, and how the authors of these stories could possibly have had enough insight and knowledge to create characters who were so clearly su�ering from mental illness hundreds of years before these illnesses were even classi�ed or de�ned.

February 2017 ISBN 978-1-60535-676-1 • paper

Forthcoming this fallNeuroscience, Sixth EditionEdited by Dale Purves, George J. Augustine, David Fitzpatrick, William C. Hall, Anthony-Samuel LaMantia, Richard D. Mooney, Michael L. Platt, and Leonard E. White

Neuroscience, Sixth Edition is written primarily for medical, premedical, and undergraduate students. New chapters in Unit V, Complex Brain Functions, re�ect the rapid growth of cognitive neuroscience. For instructors, new clinical cases teach neuroanatomical principles for “localizing lesions” in the nervous system. Included with the purchase of every new book is a one-year subscription to Sylvius 4 Online.

September 2017 ISBN 978-1-60535-380-7 • casebound

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