muscular system. functions: movement posture heat production protection
TRANSCRIPT
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CHAPTER EIGHT
MUSCULARSYSTEM
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FUNCTIONS:MOVEMENTPOSTUREHEAT PRODUCTIONPROTECTION
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3 TYPES OF MUSCLE TISSUESMOOTH MUSCLE:
InvoluntaryOne nucleus, no striations, tapered at endsDigestive tract, blood vessels
SKELETAL MUSCLE:VoluntaryMultinucleated, striations, cylindrical
CARDIAC MUSCLE:InvoluntaryOne nucleus, striations, intercalated disks
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SMOOTH MUSCLE
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CharacteristicsConnect to form “syncytia” (similar to cardiac)Impulses and contractions occur much more slowly than
cardiac muscle, howeverCause wave-like movement, called “peristalsis”
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Skeletal Muscle Characteristics
Long, multi-nucleated cylindersSeparated by connective tissueEach cell stimulated by motor
neuron
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Skeletal Muscle E.M.
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Skeletal MUSCLE
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Cardiac Muscle CharacteristicsFaintly striated, branchedConnect by intercalated discs to form
a “network”Action potential travels through all
cells connected together in the “syncytium”
Function as a unit
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CARDIAC MUSCLE
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Type of muscle? Skeletal
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Type of muscle? Cardiac
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Type of muscle? Smooth
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Organization of (skeletal) muscleSkeletal muscle fibers
located in musclesOrganized into fiber bundles
called fascicles (fasciculi)Surrounded by perimysium,
connective tissue layer
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MembranesPortions of perimysium
extend into the endomysiumThin layer of CT that covers
each muscle fiberMuscle fiber (bundle)=
multinucleate cellPerimysium also extends to
the CT that surrounds the muscle, the epimysium
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Sarcoplasmic ReticulumEach myofibril is surrounded by network of tubes and
storage sacs (Transverse tubules and sarcoplasmic reticulum)
Releases Ca2+ ions when stimulated by motor neuronTriggers contraction (more on this later…)
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SARCOMERESarcomere= basic (functional)
contractile unitSeparated by each other by dark Z
lines/discsActin & myosin slide past each other
as the muscle contractsContraction requires Ca2+ and ATP
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Other Key Points About Sarcomeres
Z-line/discI Bands
Lighter areas of non-overlap between actin and myosinContain the Z-lines.
Dark Bands = A BandsAreas where some overlap occurs= “Striations” on the slideCoincide with the length of myosin myofilaments.
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MICROSCOPIC STRUCTURE
FIBERS: grouped into bundles (fasciculi)
= 1 cell!Fibers contain myofibrils
with:ACTIN: thin myofilamentsMYOSIN: thick
myofilaments
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Another look…
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Muscular SystemPhysiology of the Muscle
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Myosin head “primer”…
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Sliding filament theoryIn the absence of Calcium
ions…Tropomyosin blocks
access to the myosin binding site of actin.
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When Calcium is released by the Sarcoplasmic reticulumit diffuses into the musclesbinds to the troponinshifting the troponin and tropomyosin
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Myosin splits ATP and undergoes a conformational change into a high-energy state.
The head of myosin binds to actin Forms a cross-bridge between the thick and thin
filaments.
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The energy stored by myosin is releasedADP and phosphate released from myosin.
The myosin molecule relaxesCauses rotation of the globular headThis leads to the sliding of the filaments.
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ATP binds to cross bridge, causing cross bridge to disconnect from actin.
Splitting of ATP leads to re-energizing/ repositioning of the cross bridge.
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Ca2+ ions transported back to sarcoplasmic reticulum (req. ATP)
When the calcium level decreasestroponin locks tropomyosin back into the blocking position thin filament (actin) slides back to the resting state (when
ATP binds to myosin head)
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Review of the Role of ATP1. ATP transfers its energy to the myosin cross bridge,
which in turn energizes the power stroke. 2. ATP disconnects the myosin cross bridge from the
binding site on actin. 3. ATP fuels the pump that actively transports calcium
ions back into the sarcoplasmic reticulum.
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Motor UnitStimulation of a muscle by a nerve impulse (motor
nerve) is required before a muscle can shortenNeuromuscular junction: point of contact b/w nerve
ending and the muscle fiber it innervates.Motor unit: motor neuron + muscle cell
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Neuromuscular Junction
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Motor Unit
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Muscle Stimulus
Threshold stimulus: minimal level of stimulation required to cause a muscle fiber to contract
All-or-none response: once stimulated, a muscle fiber will contract completely
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Types of ContractionsTwitch contractions: a single contraction of a muscle fiber
caused by a single threshold stimulusTetanic contractions: sustained and steady muscular
contractions caused by a series of stimuli bombarding a muscle in rapid succession
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Isotonic vs. Isometric ContractionIsotonic Contraction
Produces movement at the jointMuscle shortens
IsometricDoes not produce movement at
the jointMuscle does not shorten but
tension within the muscle increases
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Antagonist vs. Agonist MusclesAgonistic muscles have the same action
Adductor magnus, adductor brevisVastus intermedius, rectus femoris
Antagonistic muscles have opposites actions (when one is fully contracted, the other must be relaxed)Biceps brachii, triceps brachiiForearm flexors, forearm extensorsRectus abdominus, erector spinae
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Strength vs. EnduranceStrength training…
Increases number of muscle fibers’ myofilaments (causes increase in diameter)
Increases bulk of muscle (hypertrophy)Endurance training…
Increases number of mitochondria in muscle cell