module 1.1: overview of the laser breast scanner
DESCRIPTION
Module 1.1: Overview of the Laser Breast Scanner. Albert Cerussi Beckman Laser Institute University of California, Irvine. Module Goal. Basic hardware and models used in the Laser Breast Scanner Detail for each step covered in other modules Assumes basic knowledge of diffuse optics. - PowerPoint PPT PresentationTRANSCRIPT
Module 1.1:Overview of the
Laser Breast Scanner
Albert Cerussi
Beckman Laser InstituteUniversity of California, Irvine
NTROI DOS Workshop, 2007 Module 1.1
Module Goal
• Basic hardware and models used in the Laser Breast Scanner
• Detail for each step covered in other modules
• Assumes basic knowledge of diffuse optics
NTROI DOS Workshop, 2007 Module 1.1
Outline• Overview
• Diffuse Optical Models
• LBS Hardware
• LBS Data acquisition
NTROI DOS Workshop, 2007 Module 1.1
Overview• tissue spectroscopy
• uses handheld probe
• similar to an ultrasound
• Diffuse Optical Spectroscopy
NTROI DOS Workshop, 2007 Module 1.1
• tissue spectroscopy
• uses handheld probe
• similar to an ultrasound
• Diffuse Optical Spectroscopy
Overview
NTROI DOS Workshop, 2007 Module 1.1
Overview• tissue spectroscopy
• uses handheld probe
• similar to an ultrasound
• Diffuse Optical Spectroscopy
NTROI DOS Workshop, 2007 Module 1.1
Overview• tissue spectroscopy
• uses handheld probe
• similar to an ultrasound
• Diffuse Optical Spectroscopy
NTROI DOS Workshop, 2007 Module 1.1
Overview• tissue spectroscopy
• uses handheld probe
• similar to an ultrasound
• Diffuse Optical Spectroscopy
NTROI DOS Workshop, 2007 Module 1.1
Overview• tissue spectroscopy
• uses handheld probe
• similar to an ultrasound
• Diffuse Optical Spectroscopy650 700 750 800 850 900 950 1000
0.0
0.2
0.4
0.6
0.8
1.0
EXTI
NCTI
ON
(mm
-1 m
M -1
)WAVELENGTH (nm)
ctHHb (deoxy hemoglobin)
ctO2Hb (oxy hemoglobin)
ctH2O (water)
bulk lipids
NTROI DOS Workshop, 2007 Module 1.1
LBS Technology/Models
Frequency-domain– Modulated laser diodes– Multi-frequency– Single distance– Discrete (6 )– Absolute optical properties
Steady-State– Tungsten-Halogen lamp– Steady-state– Single distance– Broadband (650-1000nm)– Relative optical spectra
• frequency-domain and steady-state spectroscopies
NTROI DOS Workshop, 2007 Module 1.1
DOS Models: FDPM
)31(1)(2 Dvi
Dk a
a
a
Fishkin, J. B., Fantini, S., Vandeven, M. J. and Gratton, E., "Gigahertz photon density waves in a turbid medium: Theory and experiments," Phys. Rev. E, 53, pp. 2307-19, 1996.
rkrvD
iSrU )(exp14
)](exp[)(),( 0
P1 Approximation to the Transport Equation:
Cerussi, A. and Tromberg, B., "Photon migration spectroscopy: Frequency domain techniques," in Biomedical photonics handbook, Vo-Dinh, T., Ed., 1st ed.: CRC Press, 2003, pp. 22.1-.17.
Infinite medium
Wave vector
)'(3 sa
vvD
Optical diffusion
NTROI DOS Workshop, 2007 Module 1.1
DOS Models: FDPM
j
jeff RR
RRR
2
2/
0)()cos()sin(2
FresnelRdR
treff
effb l
RR
z
11
32
Haskell, R. C., Svaasand, L. O., Tsong-Tseh, T., Ti-Chen, F., Mcadams, M. S. and Tromberg, B. J., "Boundary conditions for the diffusion equation in radiative transfer," J. Opt. Soc. Am. A, 11, pp. 2727-41, 1994.
Boundary Condition (semi-infinite)
Partial current/Extrapolated Boundary condition
2/
0
2 )()(cos)sin(3
Fresnelj RdR
Effective source depth
NTROI DOS Workshop, 2007 Module 1.1
DOS Models: FDPM
22
4)(),(
vD
SAsi
brealb
bimagrealo
rkr
rrkrkr 0
0000 )(exp1))((cos)(exp1
brealb
bimag rkr
rrk 00
00 )(exp1))((sin
)(arctan)(),( 00
rk imagsi
From the photon density:
Photon density amplitude
Photon density phase
where …
Cerussi, A. and Tromberg, B., "Photon migration spectroscopy: Frequency domain techniques," in Biomedical photonics handbook, Vo-Dinh, T., Ed., 1st ed.: CRC Press, 2003, pp. 22.1-.17.
NTROI DOS Workshop, 2007 Module 1.1
DOS Models: SS
)cos()cos(),(
3),()(141),(
2
dztr
DtrRdtrR surfsurfFresnel
),(306.0),(118.0),( trRtrtrR fsurf
Kienle, A. and Patterson, M. S., "Improved solutions of the steady-state and the time-resolved diffusion equations for reflectance from a semi-infinite turbid medium," J Opt Soc Am A, 14, pp. 246-54, 1997.
Reflectance
for n=1.4
fluence flux
NTROI DOS Workshop, 2007 Module 1.1
LBS HardwareNETWORK ANALYZER
S R A
BRIDGE
RF SWITCH
T
T
T
T
T
T
DC SOURCE
SPECTROMETER
APD
LAMP
HANDPIECE
TISSUE
NTROI DOS Workshop, 2007 Module 1.1
LBS HardwareEach method calibrated separately
1. Frequency-domain– unknown source terms (S(), 0())– phantom of known optical properties
2. Steady-state– unknown spectral response– ideal reflector with known spectral response
NTROI DOS Workshop, 2007 Module 1.1
LBS HardwareWARNING!
It is essential that these calibrations are performed properly.
- data quality compromised - data may be useless
NTROI DOS Workshop, 2007 Module 1.1
LBS Data Acquisition
modulation
0 20 40 60 80 100
0.0
0.5
1.0
1.5
2.0
INTE
NSIT
Y
TIME (s)
50 MHz
~ 1 ms
NTROI DOS Workshop, 2007 Module 1.1
LBS Data Acquisition
modulation
0 20 40 60 80 100
0.0
0.5
1.0
1.5
2.0
INTE
NSIT
Y
TIME (s)
50 MHz
~ 1 ms201 frequency sweep
0 20 40 60 80 100
0.0
0.5
1.0
1.5
2.0
INTE
NSIT
Y
TIME (s)
100 MHz
NTROI DOS Workshop, 2007 Module 1.1
LBS Data Acquisition
modulation
0 20 40 60 80 100
0.0
0.5
1.0
1.5
2.0
INTE
NSIT
Y
TIME (s)
50 MHz
~ 1 ms
0 20 40 60 80 100
0.0
0.5
1.0
1.5
2.0
INTE
NSIT
Y
TIME (s)
100 MHz
201 frequency sweep
50-500 MHz(~ 200 ms)
NTROI DOS Workshop, 2007 Module 1.1
LBS Data Acquisition
100 200 300 400 500
FREQUENCY (MHz)
20
40
60
80
100
120
140
160
180
PHA
SE (d
eg)
100 200 300 400 500
1.5
2.0
2.5
3.0
3.5
4.0
4.5
AMPL
ITUD
E (a
.u.)
FREQUENCY (MHz)
modulation
diffusion model
NTROI DOS Workshop, 2007 Module 1.1
LBS Data Acquisition
100 200 300 400 500
FREQUENCY (MHz)
20
40
60
80
100
120
140
160
180
PHA
SE (d
eg)
100 200 300 400 500
1.5
2.0
2.5
3.0
3.5
4.0
4.5
AMPL
ITUD
E (a
.u.)
FREQUENCY (MHz)
modulation
diffusion model
global fit
NTROI DOS Workshop, 2007 Module 1.1
LBS Data Acquisition
100 200 300 400 500
FREQUENCY (MHz)
20
40
60
80
100
120
140
160
180
PHA
SE (d
eg)
100 200 300 400 500
1.5
2.0
2.5
3.0
3.5
4.0
4.5
AMPL
ITUD
E (a
.u.)
FREQUENCY (MHz)
modulation
diffusion model
global fit
optical properties
NTROI DOS Workshop, 2007 Module 1.1
LBS Data Acquisition
650 700 750 800 850 900 950 10000.000
0.003
0.006
0.009
0.012
ABSO
RPTI
ON
(mm
-1 )
WAVELENGTH (nm)
modulation
absorption &scattering
diffusionmodel
650 700 750 800 850 900 950 10000.5
0.6
0.7
0.8
0.9
1.0
1.1
SCAT
TERI
NG (m
m-1)
WAVELENGTH (nm)
NTROI DOS Workshop, 2007 Module 1.1
LBS Data Acquisition
650 700 750 800 850 900 950 10000.000
0.003
0.006
0.009
0.012
ABSO
RPTI
ON
(mm
-1 )
WAVELENGTH (nm)
modulation
absorption &scattering
diffusionmodel
650 700 750 800 850 900 950 10000.5
0.6
0.7
0.8
0.9
1.0
1.1
SCAT
TERI
NG (m
m-1)
WAVELENGTH (nm)
power law
SPSAscattering
NTROI DOS Workshop, 2007 Module 1.1
LBS Data Acquisition
650 700 750 800 850 900 950 10000.000
0.003
0.006
0.009
0.012
ABSO
RPTI
ON
(mm
-1 )
WAVELENGTH (nm)
modulation
absorption &scattering
diffusionmodel
650 700 750 800 850 900 950 1000
2
4
6
8
10
REFL
ECTA
NCE
(a.u
.)
WAVELENGTH (nm)
broadbandreflectance
NTROI DOS Workshop, 2007 Module 1.1
LBS Data Acquisition
650 700 750 800 850 900 950 10000.000
0.003
0.006
0.009
0.012
ABSO
RPTI
ON
(mm
-1 )
WAVELENGTH (nm)
modulation
absorption &scattering
diffusionmodel
650 700 750 800 850 900 950 1000
2
4
6
8
10
REFL
ECTA
NCE
(a.u
.)
WAVELENGTH (nm)
broadbandreflectance
scale w FDPM
NTROI DOS Workshop, 2007 Module 1.1
LBS Data Acquisition
650 700 750 800 850 900 950 10000.000
0.003
0.006
0.009
0.012
ABSO
RPTI
ON
(mm
-1 )
WAVELENGTH (nm)
modulation
absorption &scattering
diffusionmodel
650 700 750 800 850 900 950 1000
2
4
6
8
10
REFL
ECTA
NCE
(a.u
.)
WAVELENGTH (nm)
broadbandreflectance
scale w FDPM
NTROI DOS Workshop, 2007 Module 1.1
LBS Data Acquisition
modulation
absorption &scattering
diffusionmodel
broadbandreflectance
650 700 750 800 850 900 950 10000.000
0.003
0.006
0.009
0.012 FDPM BROADBAND FOUR COMPONENT FIT
ABSO
RPTI
ON
(mm
-1 )
WAVELENGTH (nm)
NTROI DOS Workshop, 2007 Module 1.1
LBS Data Acquisition
modulation
absorption &scattering
diffusionmodel
broadbandreflectance
650 700 750 800 850 900 950 10000.000
0.003
0.006
0.009
0.012 FDPM BROADBAND FOUR COMPONENT FIT
ABSO
RPTI
ON
(mm
-1 )
WAVELENGTH (nm)
chromophore fit