mnsod from e. coli pdb structure 1vew
DESCRIPTION
Structure of Active site of MnSOD from E. coli Free and bound to Azide (N 3 ¯ ). Gln 145 Trp 168. Tyr 34. OH Cu. N 3 ¯. His 170. Thr 33 His 30. MnSOD from E. coli PDB structure 1VEW. Azide bound to MnSOD from E. coli PDB structure 1MNG. - PowerPoint PPT PresentationTRANSCRIPT
MnSOD from E. coliPDB structure 1VEW
Gln 145 Trp 168Tyr 34
Thr 33 His 30 His 170
OHCu
Azide bound to MnSOD from E. coli PDB structure 1MNG
N3¯
Structure of Active site of MnSOD from E. coliFree and bound to Azide (N3¯)
The bound N3¯ anion suggests how O2¯ approaches the active site.
Azide bound to FeSOD from E. coli PDB structure 1ISB
Azide bound to MnSOD from E. coli PDB structure 1MNG
N3¯
Orientation of azide differs in structures of Fe- and MnSOD from E. coli
Azide chanes orientation in Fe structure, raises question about active site flexibility.
MnSOD from E. coli
His 170
OH
Cu
FeSOD from M. tuberculosisPDB structure 1IDS
Gln 145His 145
The active site of FeSOD from M. tuberculosis is very similar to that of MnSOD from E. coli
Similarity of structures suggests that inhibitors of E coli MnSOD could be used against M. tuberculosis.