michal ziv-ukelson comparative structural rnaomics (pattern matching on strings,
DESCRIPTION
Michal Ziv-Ukelson Comparative Structural RNAomics (Pattern Matching on Strings, ( and Graphs Trees. Structure. Function. Context Fold. Context Fold. Applied machine learning algorithms over large datasets of solved structures. RNA Structural Search 1(STRMS). - PowerPoint PPT PresentationTRANSCRIPT
Michal Ziv-Ukelson
Comparative Structural RNAomics (Pattern Matching on Strings ,
(and Graphs Trees
Context Fold
Context Fold
• Applied machine learning algorithms over large datasets of solved structures
ACGCUGACGUAGUCAGUAGACGACAGACAGAUACGUCACCGCAGAUACGCAUAGUAGCAGUAGCAGAUGACGACGCUGACGUAGUCAGUAGACGACAGACAGAUACGUCACCGCAGAUACGCAUAGUAGCAGUAGCAGAUGACG…………………………………………………………………………………………
Genome SequenceQUERY
Are there any appearances of this structure in the genome?
RNA Structural Search 1(STRMS)
ACGCUGACGUAGUCAGUAGACGACAGACAGAUACGUCACCGCAGAUACGCAUAGUAGCAGUAGCAGAUGACGACGCUGACGUAGUCAGUAGACGACAGACAGAUACGUCACCGCAGAUACGCAUAGUAGCAGUAGCAGAUGACG…………………………………………………………………………………………
Genome Sequence millions of nucleotidesQUERY
Are there any appearances of sequences that fold similarly to
this sequence in the genome?
RNA Structural Search 2 (Stem Search)
B
C
ON CLIC
K
B
C
Stem Search
Results
Results
dashed arrows - validated targets
solid green arrows - new regulation patterns discovered in our module