list of products s. no drug name manufacturing process · by installing water meters, filing water...
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Document No.: SBP/EC/18/018/V00 Page 1 of 1
List of Products
S. No Drug Name Manufacturing Process
1 Parathyroid Hormone Microbial
2 Streptokinase Microbial
3 Insulin Glargine Microbial
4 Insulin Aspart Microbial
5 Insulin Lispro Microbial
6 Human Insulin Microbial
Consent Order No: Date:CTE-303907 12/10/2017
To,
The Applicant,
Stellis Biopharma Private Limited
Sir,
Sub: Consent for Expansion of the unit in the Existing premises under the Water (Prevention & Control of Pollution) Act,1974 & the Air (Prevention & Control of Pollution) Act, 1981
Ref: 1.CFE expansion application submitted by the organization on 24/01/2017 at Regional Office KSPCB
2.Inspection of the project site by Regional Officer
on 27/02/2017
3.Proceedings of the CCM date 21/09/2017 held on11/09/2017
With reference to the above, Karnataka State Pollution Control Board hereby accords Consent for Expansion of the unit in the existing premises under the Water (Prevention & Control of Pollution) Act, 1974 & the Air (Prevention & Control of Pollution) Act, 1981 at the location indicated below subject to the terms & conditions indicated in Schedule Annexed.
Location:
Name of the Industry: Stellis Biopharma Private Limited
Address: Plot No. 293, Bommasandra 4th Phase, Indsutrial Area, Anekal Taluk,
Industrial Area: Bommasandra Jigani Link Road, Jigani,
Taluk: Anekal-Jigani hobli, District: Bangalore UrbanCONDITIONS:
3. The applicant shall not undertake further expansion/diversification without the prior consent of the Board.4. The applicant shall obtain necessary license/clearance from other relevant statutory agencies as required under the
law.
2. This consent for establishment is valid up to 30/06/2021 from the date of issue.
1. The Consent for Expansion is granted considering the following activities:
Sr Product Name CFE Qty CFO Qty Applied Qty/Month
Units Existing/Proposed
1 r & d laboratory-biotechnology(recombinant monoclonal antibodies.... @ 2nd floor
1.0000 0.000 - NOS 1.0000 NOS Proposed
2 research & development laboratory-biotechnology(recombinant monoclonal antibodie
1.0000 1.0000 - NOS 1.0000 NOS Existing
1. The source of water shall be from Borewell
Particulars Water Consumption(KLD) Water Discharge(KLD) Water Source Existing/Proposed
Domestic Purpose 5.5 4.4 Borewell Existing
Domestic Purpose 0.5 0.4 Borewell Proposed
Others ..... 0.7 0.7 Borewell Existing
Others ..... 1.6 1.6 Borewell Proposed
I. WATER CONSUMPTION:
and shall obtain prior permission from the concerneds
authority.Total water consumption shall not exceed as indicated below:
PCB ID: 27951
Page-1
CHIEF/SENIOR ENVIRONMENTAL OFFICERPrinted through XGNe_outwardno7058--12/10/2017
e-signed(physical si
Karnataka State Pollution Control BoardParisara Bhavana,No.49, Church
Street,Bengaluru-560001Tele : 080-25589112/3, 25581383
Fax:080-25586321email id: [email protected]
(This document contains 5 pages including annexure & excluding additional conditions)
Consent No. CTE-303907 Valid upto: 30/06/2021
Consent For Establishment -Expand(CFE-EXP)
Industry Colour: RED Industry Scale: LARGE
II. WATER POLLUTION CONTROL:1. The discharge from the premises of the applicant shall pass through the terminal manhole/manholes where from the Board shall be free to collect samples in accordance with the provisions of the Act/Rules made there under.
2. The sewage/domestic efflluent shall be treated in Septic Tank with Soak pit.No overflow from the soak pit is allowed.The septic tank and Soak pit shall be as per IS 2470 Part-I & Part-II.
3. The Effluent Treatment Plant proposal is generally agreeable and shall be constructed as per the specifications mentioned in the proposal and it shall consist of following units.
4. The industry shall treat the domestic wastewater in the Sewage Treatment Plant (STP) as per the proposal submitted. It shall meet the standards specified in Annexure-I & shall be used on land for gardening/greenbelt within the factory premises.
5. If the treatment plant does not achieve the effluent standards stipulated in this consent order and/ or if it is found to be inadequate, then the industry shall have to modify the units so as to meet the standards with prior consent of the Board.
6.All the treatment units shall be totally impervious.
7.The applicant shall provide separate flow meter for measuring the quantity of effluents through ETP and separate energy meter and shall maintain a logbook for the verification of inspecting officers.
8. The applicant shall operate and maintain Treatment Plant continuously and maintain at all times to achieve the stipulated standards as per Annexure-I & also maintain regular log-books/operation records.
9.There shall not be any increase in generation of Domestic sewage due to proposed expansion.
10. There shall be no bypass or discharge of effluents either within or outside the factory premises under any circumstances.
11. There shall not be any discharge of untreated trade/domestic sewage inside/outside the industry premises.
12. The applicant shall explore the possibility of reducing freshwater consumption & adopt recycling/ reuse.
III. WATER CESS:
1. The applicant shall comply with the provisions of Water (Prevention and Control of Pollution) Cess Act, 1977, by installing water meters, filing water cess returns in Form-I and other provisions as contained in the said Water (Prevention and Control of Pollution) Cess Act, 1977, and 2003.
IV. AIR POLLUTION CONTROL:
1. The type of emissions, stack heights and the air pollution control equipment for the air pollution control sources to be installed as specified in Annexure-II.
2. The discharge of emissions from the air pollution sources shall pass through the stacks/chimneys mentioned in Annexure-II where from the Board shall be free to collect the samples at any time in accordance with the provisions of the Act and Rules made there under.
3. The stacks shall have port holes and platforms as per the guidelines specified in Annexure-II to facilitate monitoring of emissions.
4. The applicant shall upgrade/modify/replace the control equipments if they are found inadequate to meet the standards stipulated with Prior permission of the Board shall be obtained for the same.
5. There shall not be any other sources of air pollution from the proposed expansion.
6. If there is going to be any new air pollution sources in future, the project authorities shall apply and obtain consent for establishment for the same from the Board.
7. Any fugitive emission has to be controlled to meet the ambient air quality standards.
V. SOLID WASTE (OTHER THAN HAZARDOUS WASTE) DISPOSAL:
1. The applicant shall collect, treat and dispose off all solid waste generated during construction i.e. Muck, and Garbage after construction if any in such manner so as not to cause environmental pollution.
2. The details of solid waste generated from the expansion activity shall be as follows
Sr Solid Waste Name Qty-Unit Mode of Disposal1 Paper wastes, Card Board Wastes etc., 0.0100 - M.T OTH
Page-2
CHIEF/SENIOR ENVIRONMENTAL OFFICERPrinted through XGNe_outwardno7058--12/10/2017
e-signed(physical si
Karnataka State Pollution Control BoardParisara Bhavana,No.49, Church
Street,Bengaluru-560001Tele : 080-25589112/3, 25581383
Fax:080-25586321email id: [email protected]
(This document contains 5 pages including annexure & excluding additional conditions)
Consent No. CTE-303907 Valid upto: 30/06/2021
Consent For Establishment -Expand(CFE-EXP)
Industry Colour: RED Industry Scale: LARGE
2 Paper wastes, Card Board Wastes etc., 0.0100 - M.T OTH
VI.HAZARDOUS AND OTHER WASTES (MANAGEMENT & TRANSBOUNDRY MOVEMENT) RULES 2016:
1. The industry shall apply and obtain authorization under Hazardous and Other Wastes (Management &Transboundry Movement) Rules 2016, and comply with the conditions of the authorization. The applicant shall apply for authorization along with the consent for operation (CFO) application under the Rules in Form-I to obtain authorization and comply with conditions.
2. There shall not be any Hazardous Waste generation from the proposed expansion project.
VII. NOISE POLLUTION CONTROL:
1. The applicant shall ensure that the ambient noise levels within its premises shall not exceed the limits i.e 75 dB(A) Leq during day time and 70 dB(A) Leq during night time as specified in the Environment (Protection) Rules.
VIII. GENERAL CONDITIONS:
1. The applicant shall transport and store the raw materials in a manner so as not to cause any damage to environment, life and property. The applicant shall be solely responsible for any damages to environment.
2. The applicant shall not commission the proposed plant for trial or regular production unless necessary pollution control measures are installed as specified in this Consent Order.
3. The applicant shall ensure that the treatment plant and control equipments are completed and commissioned simultaneously along with construction of the factory and erection of machineries.
4. The applicant shall not change or alter (a) raw materials or manufacturing process, (b) change the products or product mix (c) the quality, quantity or rate of discharge/emissions and (d) install/replace/alter the water or air pollution control equipments without the prior approval of the Board.
5. The applicant shall immediately report to the Board of any accident or unforeseen act or event resulting in release of discharge of effluents or emissions or solid wastes etc. in excess of the standards stipulated. And the industry shall immediately take appropriate corrective and preventive actions under intimation.
6. The applicant is liable to reinstate or restore, damaged or destroyed elements of environment at his cost, failing which, the applicant/occupier as the case may be shall be liable to pay the entire cost of remediation or restoration in advance an amount equal to the cost estimated by Competent Agency or Committee.
7. The Board reserves the right to review, impose additional condition or conditions, revoke, change or alter the terms and conditions.
8. This CFE does not give any right to the Party/Project Authority/Industry to forego any other legal requirement that is necessary for setting/operation of the plant.
9. The applicant shall furnish point wise compliance to the conditions given under this consent for establishment within 30 days.
10. The applicant shall take measures to develop green belt all along the periphery of the factory premises.
11. This consent is issued without prejudice to any Court Cases pending in any Hon’ble Court 12. The applicant shall comply with all the Conditions and guidelines issued by the Board from time to time.
Please note that this is only consent for establishment issued to you to proceed with the formalities for expansion of the industry and does not give any right to proceed trial/regular production. For this purpose, separate consents of the Board for discharge of liquid effluent and the emissions to the air shall have to be obtained by remitting prescribed consent fee. The application forconsent has to be made 45 days in advance of commissioning for trial production of the plant.
The receipt of this letter may please be acknowledged.
NOTE:
The Conditions II [4], IV [ 1, 2, 3, 4 ]mentioned in the schedule are not applicable.
Error: Subreport could not be shown.
Page-3
CHIEF/SENIOR ENVIRONMENTAL OFFICERPrinted through XGNe_outwardno7058--12/10/2017
e-signed(physical si
Karnataka State Pollution Control BoardParisara Bhavana,No.49, Church
Street,Bengaluru-560001Tele : 080-25589112/3, 25581383
Fax:080-25586321email id: [email protected]
(This document contains 5 pages including annexure & excluding additional conditions)
Consent No. CTE-303907 Valid upto: 30/06/2021
Consent For Establishment -Expand(CFE-EXP)
Industry Colour: RED Industry Scale: LARGE
FOR AND ON BEHALF OF KARNATAKA STATE POLLUTION CONTROL BOARD
B N RAMESH KUMAR - CHIEF/SENIOR ENVIRONMENTAL OFFICER
Encl.: Annexure-I & II.COPY TO:
1. The Environmental Officer, KSPCB, Regional Office Bangalore Anekal for information and necessary action.
1. Master copy (Dispatch).2. Office copy.
Chim.No.
Chimney attached to
Capacity/ KVA Rating
Minimum chimney height to be provided above ground level(in Mts)
Constituents to be controlled in the emission
Tolerance limits mg/NM3
Fuel Air pollutionControl equipment to be installed,in addition to chimney height as per col.(4)
Date of which air pollution control equipments shall be provided to achieve the stipulated tolerance limits and chimney heights conforming to stipulated heights.
1 Any Other........
Fume Cupboard-3 No's(Cmn
3 PM(mg/NM3),SO2(PPM),NOx(PPM)
Acid Mist-35
SCR Before commissioning.
2 Any Other........
Fume Cupboard-4 No's(Cmn
3 PM(mg/NM3),SO2(PPM),NOx(PPM)
Acid Mist-35
SCR Before commissioning.
3 D.G. Sets
125 KVA DG Set
5 PM(mg/NM3),SO2(PPM),NOx(PPM)
0,100,0 DIE AEC Before commissioning.
4 D.G. Sets
625 KVA DG Set
20 PM(mg/NM3),SO2(PPM),NOx(PPM)
0,100,0 DIE AEC Before commissioning.
SCR : Scrubber
AEC : Accoustic Enclosures
Note:
Page-4
CHIEF/SENIOR ENVIRONMENTAL OFFICERPrinted through XGNe_outwardno7058--12/10/2017
e-signed(physical si
Karnataka State Pollution Control BoardParisara Bhavana,No.49, Church
Street,Bengaluru-560001Tele : 080-25589112/3, 25581383
Fax:080-25586321email id: [email protected]
(This document contains 5 pages including annexure & excluding additional conditions)
Consent No. CTE-303907 Valid upto: 30/06/2021
Consent For Establishment -Expand(CFE-EXP)
Industry Colour: RED Industry Scale: LARGE
LOCATION OF SAMPLING PORTHOLES, PLATFORMS, ELECTRICAL OUTLET.1. Location of Portholes and approach platform:
Portholes shall be provided for all Chimneys, stacks and other sources of emission. These shall serve as the sampling points. The sampling point should be located at a distance equal to at least eight times the stack or duct diameter downstream from any flow disturbance such as bend, expansion, contraction and visible flame. Further, the selected port has to be at least 2 stack/duct diameter before stack/duct exit or from any other flow disturbance. For rectangular stacks, an equivalent diameter can be calculated using following expression.
2 (Length x Width) Equivalent Diameter = ----------------------- (Length + Width)2. The diameter of the sampling port should not be less than 100mm dia”.Arrangements should be made so that the porthole is closed firmly during the non sampling period.
3. An easily accessible platform to accommodate 3 to 4 persons to conveniently monitor the stack emission from the portholes shall be provided. Arrangements for an Electric Outlet Point off 230 V 15 A with suitable switch control and 3 Pin Point shall be provided at the Porthole location.
4. The ladder shall be provided with adequate safety features so as to approach the monitoring location with ease.
Page-5
CHIEF/SENIOR ENVIRONMENTAL OFFICERPrinted through XGNe_outwardno7058--12/10/2017
e-signed(physical si
Karnataka State Pollution Control BoardParisara Bhavana,No.49, Church
Street,Bengaluru-560001Tele : 080-25589112/3, 25581383
Fax:080-25586321email id: [email protected]
(This document contains 5 pages including annexure & excluding additional conditions)
Consent No. CTE-303907 Valid upto: 30/06/2021
Consent For Establishment -Expand(CFE-EXP)
Industry Colour: RED Industry Scale: LARGE
Date: 30/12/2016
Combined consent for discharge of effluents under the Water (Prevention and Control of Pollution) Act , 1974 and emission under the Air (Prevention and Control of Pollution)Act , 1981
Ref: 1. Application filed by the applicant/organization on 08/08/2016
,held on 08/09/20163.Proceedings of the CCM dated 15/09/2016
2.Inspection of the Industry/organization/by RO,
on 08/08/2016on
Consent is hereby granted to the Occupier under Section 25(4) of the Water (Prevention & Control of Pollution) Act, 1974 ( herein referred to as the Water Act) & Section 21 of Air (Prevention & Control of Pollution) Act, 1981, ( herein referred to as the Air Act) and the Rules and Orders made there under and authorized the Occupier to operate /carryout industry/activity & to make discharge of the effluents & emissions confirming to the stipulated standards from the premises mentioned below and subject to the terms and conditions as detailed in the Schedule Annexed to this order.
Location:Name of the Industry: Stellis Biopharma Private Limited
Address: Plot No. 293, Bommasandra 4th Phase, Indsutrial Area, Anekal Taluk,
Industrial Area: Bommasandra Jigani Link Road, Jigani,
Taluk: Anekal-Jigani hobli, District: Bangalore UrbanConditions:
a) Discharge of effluents under the Water Act:Sr Water Code WC(KLD) WWG(KLD) Remark1 Domestic Purpose 5.500 4.400 Domestic sewage shall be
disposed into Septic tank and Soak Pit.
2 Others ..... 0.650 0.650 Washing-trade effluent shall be hand over to CETP M/s Pai & Pai Chemicals India Pvt.Ltd.,
Sl. No. Description of chimney/outlet Limits specified refer schedule
The details of Sources, control equipments and its specification, type of fuel,constituents to be controlled in emissions etc. are detailed in Annexure-II.
b) Discharge of Air emissions under the Air Act from the following stacks etc.
The consent for operation is granted considering the following activities/Products;
Sr Product Name Applied Qty/Month Unit1 Research & Development laboratory-Biotechnology(Recombinant
Monoclonal Antibodie1.0000 NOS
This consent is valid for the period from 08/08/2016 30/06/2021
For and on behalf of the Karnataka State Pollution Control Board
to
B G MOHANKRISHNA
To,
Stellis Biopharma Private Limited
Combined Consent Order No. AWH-301789 27951PCB ID:
CHIEF/SENIOR ENVIRONMENTAL OFFICERPrinted from XGNPage-1 e_outwardno3537--30/12/2016 e-signed(physical sig
Karnataka State Pollution Control BoardParisara Bhavana,No.49, Church
Street,Bengaluru-560001Tele : 080-25589112/3, 25581383
Fax:080-25586321email id: [email protected]
(This document contains 5 pages including annexure & excluding additional conditions)
Consent No. AWH-301789Valid upto: 30/06/2021
Consent For Operation(CFO-Air,Water)
Industry Colour: RED Industry Scale: LARGE
COPY TO:
The Environmental Officer, KSPCB, Regional Office Bangalore Anekal for information and necessary action.
2. Master Register.
3. Case file.
1. Consent Fee paid : Rs. 150000
SCHEDULE
TERMS AND CONDITIONS
A. TREATMENT AND DISPOSAL OF EFFLUENTS UNDER THE WATER ACT.1. The discharge from the premises of the occupier shall pass through the terminal manhole/manholes where from the Board shall be free to collect samples in accordance with the provisions of the Act/Rules made there under.
2(a). The sewage/domestic effluent shall be treated in septic tank and with soak pit. No overflow from the soak pit is allowed. The septic tank and soak pit shall be as per IS 2470 Part-I & Part-II. 2(b). The treated sewage effluent discharged shall conform to the standards specified in Annexure-I.
3(a). The trade effluent generated in the industry shall be treated in the ETP and treated effluent shall confirm to the standards stipulated by the Board in Annexure-1 3(b). The trade effluent shall be handed over to CETP and maintain logbook of effluent generated & sent every day.
4. The applicant shall install flow measuring/recording devices to record the discharge quantity and maintain the record.
5. The applicant shall not change or alter either the quality or the quantity or the place of discharge or temperature or the point of discharge without the previous consent/ permission of the Board.
6. The applicant shall not allow the discharge from the other premises to mix with the discharge from his premises. Storm water shall not be allowed to mix with the effluents on the upstream of the terminal manhole where the flow measuring devices are installed.
7. The daily quantity of domestic effluent and trade effluent from the industry shall not exceed the limits as indicated in this consent order:
8. The applicant shall discharge the effluents only to the place mentioned in the Consent order and discharge of treated/untreated outside the premises is not permitted.
B. EMISSIONS:
1. The discharge of emissions from the premises of the applicant shall pass through the air pollution control equipment and discharged through stacks/chimneys mentioned in Annexure-II where from the Board shall be free to collect the samples at any time in accordance with the provisions of the Act and Rules made there under.The tolerance limits of the constituents forming the emissions in each of the stacks shall not exceed the limits laid down in Annexure-II.
2. The applicant shall provide port holes for sampling of emission, access platforms for carrying out stack sampling, electrical points and all other necessary arrangements including ladder as indicated in Annexure-II.
3. The applicant shall upgrade/modify/replace the control equipment with prior permission of the Board.
C. WATER CESS:
1. The applicant shall provide water meter at all the intake points as specified under Section (5) of the Water Cess Act, 1977 and shall file the Water Cess returns regularly before fifth of every month and also pay the Cess assessed with the time stipulated.
CHIEF/SENIOR ENVIRONMENTAL OFFICERPrinted from XGNPage-2 e_outwardno3537--30/12/2016 e-signed(physical sig
Karnataka State Pollution Control BoardParisara Bhavana,No.49, Church
Street,Bengaluru-560001Tele : 080-25589112/3, 25581383
Fax:080-25586321email id: [email protected]
(This document contains 5 pages including annexure & excluding additional conditions)
Consent No. AWH-301789Valid upto: 30/06/2021
Consent For Operation(CFO-Air,Water)
Industry Colour: RED Industry Scale: LARGE
D.MONITORING & REPORTING:
1. The applicant shall get the samples of effluents & emissions collected and get them analyzed once a month/either by in house monitoring laboratory or through EP approved laboratories for the parameters as Indicated in Annexure I & II.
2. The applicant shall maintain log books to reflect the working condition of pollution control systems and also self monitoring results and keep it open for inspection.
E. SOLID WASTE (OTHER THAN HAZARDOUS WASTE) DISPOSAL:
1.The applicant shall segregate solid waste from Hazardous Waste, Municipal Solid Waste and store it properly till treatment/disposal without causing pollution to the surrounding Environment.
2.The solid waste generated shall be handled & disposed by scientific method without causing eye sore to the general public and to the surrounding environment.
F. NOISE POLLUTION CONTROL:
1. The industry shall ensure that the ambient noise levels within its premises shall not exceed the limits i.e 75 dB(A) Leq during day time and 70 dB(A) Leq during night time as specified in under the Air (Prevention and Control of Pollution) Act, 1981.
G. HAZARDOUS WASTES (MANAGEMENT, HANDLING & TRANSBOUDARY MOVEMENT) 2008:
The applicant shall comply with the provisions of the Hazardous Wastes (Management, Handling & Transboundry Movement) Rules 2008.
H. GENERAL CONDITIONS:
1. The applicant shall not allow the discharge from the other premises to mix with the discharge from his premises.
2. The applicant shall promptly comply with all orders and instructions issued by the Board from time to time or any other officers of the Board duly authorized in this behalf.
3. The applicant shall set-up Environmental Cell comprising of qualified and competent personnel for complying with the conditions specified.
4. The Board reserves the right to review, impose additional conditions, revoke, change or alter terms and conditions of this consent.
5. The applicant shall forthwith keep the Board informed of any accidental discharge of emissions/effluents into the atmosphere in excess of the standards laid down by the Board. The applicant shall also take corrective steps to mitigate the impact.
6. The applicant shall provide alternative power supply sufficient to operate all Pollution control equipments.
7. The entire premises shall always be kept clean. The effluent holding area, inspection chambers, outlets, flow measuring points should made easily approachable.
8. The applicant shall display the consent granted in a prominent place for perusal of the inspecting officers of the Board.
9. The applicant his heirs, legal representatives or assignee shall have no claims what so ever to the continuation or renewal of this consent after expiry of the validity of consent.
CHIEF/SENIOR ENVIRONMENTAL OFFICERPrinted from XGNPage-3 e_outwardno3537--30/12/2016 e-signed(physical sig
Karnataka State Pollution Control BoardParisara Bhavana,No.49, Church
Street,Bengaluru-560001Tele : 080-25589112/3, 25581383
Fax:080-25586321email id: [email protected]
(This document contains 5 pages including annexure & excluding additional conditions)
Consent No. AWH-301789Valid upto: 30/06/2021
Consent For Operation(CFO-Air,Water)
Industry Colour: RED Industry Scale: LARGE
10. The applicant shall make an application for consent for subsequent period at least 45 days before expiry of this consent.
11. The applicant shall develop and maintain adequate green belt all around the periphery.
12. The applicant shall provide rain water harvesting system and shall provide proper storm water management system.
13.This consent is issued without prejudice to any Court Cases pending in any Hon’ble Court
14. The applicant shall furnish the Environmental statement for every financial year ending with 31st March in Form-V as per Environment (Protection) Rules, 1986. The statement shall be furnished before the end of September.
15.The applicant shall display flow diagram of the pollution control system near the pollution contol system/s.
NOTE:
The following Conditions A[ 2b ] mentioned in the schedule are not applicable.
Enclosed as Annexure-A.
Additional Conditions:
For and on behalf of the Karnataka State Pollution Control Board
B G MOHANKRISHNA
Note: All efforts should be made to remove colour and unpleasant odour as far as practicable.
CHIEF/SENIOR ENVIRONMENTAL OFFICERPrinted from XGNPage-4 e_outwardno3537--30/12/2016 e-signed(physical sig
Karnataka State Pollution Control BoardParisara Bhavana,No.49, Church
Street,Bengaluru-560001Tele : 080-25589112/3, 25581383
Fax:080-25586321email id: [email protected]
(This document contains 5 pages including annexure & excluding additional conditions)
Consent No. AWH-301789Valid upto: 30/06/2021
Consent For Operation(CFO-Air,Water)
Industry Colour: RED Industry Scale: LARGE
Chim.No.
Chimney attached to
Capacity/ KVA Rating
Minimum chimney height to be provided above ground level(in Mts)
Constituents to be controlled in the emission
Tolerance limits mg/NM3
Fuel Air pollutionControl equipment to be installed,in addition to chimney height as per col.(3)
Date of which air pollution control equipments shall be provided to achieve the stipulated tolerance limits and chimney heights conforming to stipulated heights.
1 Any Other........
Fume Cupboard-3 No's(Cmn
3 PM(mg/NM3),SO2(PPM),NOx(PPM)
Acid Mist-35
SCR Before commissioning.
2 Any Other........
Fume Cupboard-4 No's(Cmn
3 PM(mg/NM3),SO2(PPM),NOx(PPM)
Acid Mist-35
SCR Before commissioning.
3 D.G. Sets
125 KVA DG Set
5 PM(mg/NM3),SO2(PPM),NOx(PPM)
0,100,0 DIE AEC Before commissioning.
4 D.G. Sets
625 KVA DG Set
20 PM(mg/NM3),SO2(PPM),NOx(PPM)
0,100,0 DIE AEC Before commissioning.
SCR : Scrubber
AEC : Accoustic Enclosures
Note:
Note: 1. The Noise levels within the premises shall not exceed 75 dB (A) leq during day time and 70 dB(A) leq during night time respectively. 2. The DG set shall be provided with acoustic measures as per SI.No.94 in Schedule-I of Environment (Protection)Rules. 3. There shall be no smell or odour nuisance from the industry.
LOCATION OF SAMPLING PORTHOLES, PLATFORMS, ELECTRICAL OUTLET.
1. Location of Portholes and approach platform:
Portholes shall be provided for all chimneys, stacks and other sources of emission. These shall serve as the sampling points. The sampling point should be located at a distance equal to atleast eight times the stack or duct diameters downstream and two diameters upstream from source of low disturbance such as a Bend, Expansion, Construction Valve, Fitting or Visible Flame for rectangular stacks, the equivalent diameter can be calculated from the following equation.
2 (Length x Width) Equivalent Diameter = ----------------------- (Length + Width)
2. The diameter of the sampling port should not be less than 100 mm dia”. Arrangements should be made so that the porthole is closed firmly during the non sampling period
3. An easily accessible platform to accommodate 3 to 4 persons to conveniently monitor the stack emission from the portholes shall be provided. Arrangements for an Electric Outlet Point of 230 V 15 A with suitable switch control and 3 Pin Point shall be provided at the Porthole location.
4. The ladder shall be provided with adequate safety features so as to approach the monitoring location with ease.
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CHIEF/SENIOR ENVIRONMENTAL OFFICERPrinted from XGNPage-5 e_outwardno3537--30/12/2016 e-signed(physical sig
Karnataka State Pollution Control BoardParisara Bhavana,No.49, Church
Street,Bengaluru-560001Tele : 080-25589112/3, 25581383
Fax:080-25586321email id: [email protected]
(This document contains 5 pages including annexure & excluding additional conditions)
Consent No. AWH-301789Valid upto: 30/06/2021
Consent For Operation(CFO-Air,Water)
Industry Colour: RED Industry Scale: LARGE
Date: 21/06/2018
Combined consent for discharge of effluents under the Water (Prevention and Control of Pollution) Act , 1974 and emission under the Air (Prevention and Control of Pollution)Act , 1981
Ref: 1. Application filed by the applicant/organization on
,held on 06/04/20183.Proceedings of the CCM dated 23/04/2018
on 16/02/20182.Inspection of the Industry/organization/by RO,
24/02/2018
Consent is hereby granted to the Occupier under Section 25(4) of the Water (Prevention & Control of Pollution) Act, 1974 ( herein referred to as the Water Act) & Section 21 of Air (Prevention & Control of Pollution) Act, 1981, ( herein referred to as the Air Act) and the Rules and Orders made there under and authorized the Occupier to operate /carryout industry/activity & to make discharge of the effluents & emissions confirming to the stipulated standards from the premises mentioned below and subject to the terms and conditions as detailed in the Schedule Annexed to this order.
Location:Name of the Industry: Stellis Biopharma Private Limited
Address: Plot No. 293, Bommasandra 4th Phase, Indsutrial Area, Anekal Taluk,
Industrial Area: Bommasandra Jigani Link Road, Jigani,
Taluk: Anekal-Jigani hobli, District: Bangalore UrbanCONDITIONS:
a) Discharge of effluents under the Water Act:Sr Water Code WC(KLD) WWG(KLD) Remark1 Domestic Purpose 5.500 4.400 Shall be treated in 10 KLD
Combined ETP and used onland for gardening and toilet flushing.
2 Domestic Purpose 0.500 0.360 Proposed -Shall be treated in 10 KLD Combined ETP and used onland for gardening and toilet flushing.
3 Others ..... 0.650 0.650 Shall be treated in 10 KLD Combined ETP and used onland for gardening and toilet flushing.
4 Others ..... 1.600 1.600 Proposed - Shall be treated in 10 KLD Combined ETP and used onland for gardening and toilet flushing
Sl. No. Description of chimney/outlet Limits specified refer schedule
The details of Sources, control equipments and its specification, type of fuel,constituents to be controlled in emissions etc. are detailed in Annexure-II.
b) Discharge of Air emissions under the Air Act from the following stacks etc.
The consent for operation is granted considering the following activities/Products;
Sr Product Name Applied Qty/Month Unit1 R&D laboratory-biotechnology(recombinant monoclonal
antibiotics....@2nd floor1.0000 NOS
2 Research & Development laboratory-Biotechnology(Recombinant Monoclonal Antibodie
1.0000 NOS
This consent is valid for the period from 24/02/2018 30/06/2021
For and on behalf of the Karnataka State Pollution Control Board
to
B N RAMESH KUMAR - CHIEF/SENIOR ENVIRONMENTAL OFFICER
Combined Consent Order No. W-306482 27951PCB ID:
CHIEF/SENIOR ENVIRONMENTAL OFFICERPrinted from XGNPage-1 e_outwardno11463--21/06/2018 e-signed(physical sig
Karnataka State Pollution Control BoardParisara Bhavana,No.49, Church
Street,Bengaluru-560001Tele : 080-25589112/3, 25581383
Fax:080-25586321email id: [email protected]
(This document contains 5 pages including annexure & excluding additional conditions)
Consent No. W-306482Valid upto: 30/06/2021
Consent For Operation(CFO-Air,Water)
Industry Colour: RED Industry Scale: LARGE
To,
Stellis Biopharma Private Limited
COPY TO:
The Environmental Officer, KSPCB, Regional Office Bangalore Anekal for information and necessary action.
2. Master Register.
3. Case file.
Consent Fee paid : Rs. 250000
SCHEDULE
TERMS AND CONDITIONS
A. TREATMENT AND DISPOSAL OF EFFLUENTS UNDER THE WATER ACT.1. The discharge from the premises of the occupier shall pass through the terminal manhole/manholes where from the Board shall be free to collect samples in accordance with the provisions of the Act/Rules made there under.
2(a). The sewage/domestic effluent shall be treated in septic tank and with soak pit. No overflow from the soak pit is allowed. The septic tank and soak pit shall be as per IS 2470 Part-I & Part-II. 2(b). The treated sewage effluent discharged shall conform to the standards specified in Annexure-I.
3(a). The trade effluent generated in the industry shall be treated in the ETP and treated effluent shall confirm to the standards stipulated by the Board in Annexure-I 3(b). The trade effluent shall be handed over to CETP and maintain logbook of effluent generated & sent every day.
4. The applicant shall install flow measuring/recording devices to record the discharge quantity and maintain the record.
5. The applicant shall not change or alter either the quality or the quantity or the place of discharge or temperature or the point of discharge without the previous consent/ permission of the Board.
6. The applicant shall not allow the discharge from the other premises to mix with the discharge from his premises. Storm water shall not be allowed to mix with the effluents on the upstream of the terminal manhole where the flow measuring devices are installed.
7. The daily quantity of domestic effluent and trade effluent from the industry shall not exceed the limits as indicated in this consent order:
8. The applicant shall discharge the effluents only to the place mentioned in the Consent order and discharge of treated/untreated outside the premises is not permitted.
B. EMISSIONS:
1. The discharge of emissions from the premises of the applicant shall pass through the air pollution control equipment and discharged through stacks/chimneys mentioned in Annexure-II where from the Board shall be free to collect the samples at any time in accordance with the provisions of the Act and Rules made there under.The tolerance limits of the constituents forming the emissions in each of the stacks shall not exceed the limits laid down in Annexure-II.
2. The applicant shall provide port holes for sampling of emission, access platforms for carrying out stack sampling, electrical points and all other necessary arrangements including ladder as indicated in Annexure-II.
3. The applicant shall upgrade/modify/replace the control equipment with prior permission of the Board.
CHIEF/SENIOR ENVIRONMENTAL OFFICERPrinted from XGNPage-2 e_outwardno11463--21/06/2018 e-signed(physical sig
Karnataka State Pollution Control BoardParisara Bhavana,No.49, Church
Street,Bengaluru-560001Tele : 080-25589112/3, 25581383
Fax:080-25586321email id: [email protected]
(This document contains 5 pages including annexure & excluding additional conditions)
Consent No. W-306482Valid upto: 30/06/2021
Consent For Operation(CFO-Air,Water)
Industry Colour: RED Industry Scale: LARGE
C. WATER CESS:
1. The applicant shall provide water meter at all the intake points as specified under Section (5) of the Water Cess Act, 1977 and shall file the Water Cess returns regularly before fifth of every month and also pay the Cess assessed with the time stipulated.
D.MONITORING & REPORTING:
1. The applicant shall get the samples of effluents & emissions collected and get them analyzed once a month/either by in house monitoring laboratory or through EP approved laboratories for the parameters as Indicated in Annexure I & II.
2. The applicant shall maintain log books to reflect the working condition of pollution control systems and also self monitoring results and keep it open for inspection.
E. SOLID WASTE (OTHER THAN HAZARDOUS WASTE) DISPOSAL:
1.The applicant shall segregate solid waste from Hazardous Waste, Municipal Solid Waste and store it properly till treatment/disposal without causing pollution to the surrounding Environment.
2.The solid waste generated shall be handled & disposed by scientific method without causing eye sore to the general public and to the surrounding environment.
F. NOISE POLLUTION CONTROL:
1. The applicant shall ensure that the ambient noise levels within its premises shall not exceed the limits i.e 75 dB(A) Leq during day time and 70 dB(A) Leq during night time as specified in under the Air (Prevention and Control of Pollution) Act, 1981.
G. HAZARDOUS AND OTHER WASTES (MANAGEMENT & TRANSBOUDARY MOVEMENT)Rules 2016:
The applicant shall comply with the provisions of the Hazardous and other Wastes (Management & Transboundry Movement) Rules 2016.
H. GENERAL CONDITIONS:
1. The applicant shall not allow the discharge from the other premises to mix with the discharge from his premises.
2. The applicant shall promptly comply with all orders and instructions issued by the Board from time to time or any other officers of the Board duly authorized in this behalf.
3. The applicant shall set-up Environmental Cell comprising of qualified and competent personnel for complying with the conditions specified.
4. The Board reserves the right to review, impose additional conditions, revoke, change or alter terms and conditions of this consent.
5. The applicant shall forthwith keep the Board informed of any accidental discharge of emissions/effluents into the atmosphere in excess of the standards laid down by the Board. The applicant shall also take corrective steps to mitigate the impact.
6. The applicant shall provide alternate power supply sufficient to operate all Pollution control equipments.
7. The entire premises shall always be kept clean. The effluent holding area, inspection chambers, outlets, flow measuring points should made easily approachable.
8. The applicant shall display the consent granted in a prominent place for perusal of the inspecting officers of the Board.
9. The applicant his heirs, legal representatives or assignee shall have no claims what so ever to the continuation or renewal of this consent after expiry of the validity of consent.
CHIEF/SENIOR ENVIRONMENTAL OFFICERPrinted from XGNPage-3 e_outwardno11463--21/06/2018 e-signed(physical sig
Karnataka State Pollution Control BoardParisara Bhavana,No.49, Church
Street,Bengaluru-560001Tele : 080-25589112/3, 25581383
Fax:080-25586321email id: [email protected]
(This document contains 5 pages including annexure & excluding additional conditions)
Consent No. W-306482Valid upto: 30/06/2021
Consent For Operation(CFO-Air,Water)
Industry Colour: RED Industry Scale: LARGE
10. The applicant shall make an application for consent for subsequent period at least 45 days before expiry of this consent.
11. The applicant shall develop and maintain adequate green belt all around the periphery.
12. The applicant shall provide rain water harvesting system and shall provide proper storm water management system.
13.This consent is issued without prejudice to any Court Cases pending in any Hon’ble Court
14. The applicant shall furnish the Environmental statement for every financial year ending with 31st March in Form-V as per Environment (Protection) Rules, 1986. The statement shall be furnished before the end of September.
15.The applicant shall display flow diagram of the pollution control system near the pollution contol system/s.
NOTE:
The Conditions A [ 2a, 2b, 3b ] mentioned in the schedule are not applicable.
The applicant shall comply with all the additional conditions stipulated in the Annexure enclosed with this consent (Please download Annexure-A from uploaded document).
Additional Conditions:
For and on behalf of the Karnataka State Pollution Control Board
B N RAMESH KUMAR - CHIEF/SENIOR ENVIRONMENTAL OFFICER
CHIEF/SENIOR ENVIRONMENTAL OFFICERPrinted from XGNPage-4 e_outwardno11463--21/06/2018 e-signed(physical sig
Karnataka State Pollution Control BoardParisara Bhavana,No.49, Church
Street,Bengaluru-560001Tele : 080-25589112/3, 25581383
Fax:080-25586321email id: [email protected]
(This document contains 5 pages including annexure & excluding additional conditions)
Consent No. W-306482Valid upto: 30/06/2021
Consent For Operation(CFO-Air,Water)
Industry Colour: RED Industry Scale: LARGE
Chim.No.
Chimney attached to
Capacity/ KVA Rating
Minimum chimney height to be provided above ground level(in Mts)
Constituents to be controlled in the emission
Tolerance limits mg/NM3
Fuel Air pollutionControl equipment to be installed,in addition to chimney height as per col.(4)
Date of which air pollution control equipments shall be provided to achieve the stipulated tolerance limits and chimney heights conforming to stipulated heights.
1 Any Other........
Fume Cupboard-3 No's(Cmn
3 PM(mg/NM3),SO2(PPM),NOx(PPM)
Acid Mist-35
SCR Before commissioning.
2 Any Other........
Fume Cupboard-4 No's(Cmn
3 PM(mg/NM3),SO2(PPM),NOx(PPM)
Acid Mist-35
SCR Before commissioning.
3 D.G. Sets
125 KVA DG Set
5 PM(mg/NM3),SO2(PPM),NOx(PPM)
0,100,0 DIE AEC Before commissioning.
4 D.G. Sets
625 KVA DG Set
20 PM(mg/NM3),SO2(PPM),NOx(PPM)
0,100,0 DIE AEC Before commissioning.
SCR : Scrubber
AEC : Accoustic Enclosures
Note:
Note: 1. The Noise levels within the premises shall not exceed 75 dB (A) leq during day time and 70 dB(A) leq during night time respectively. 2. The DG set shall be provided with acoustic measures as per SI.No.94 in Schedule-I of Environment (Protection)Rules. 3. There shall be no smell or odour nuisance from the industry.
LOCATION OF SAMPLING PORTHOLES, PLATFORMS, ELECTRICAL OUTLET.
1. Location of Portholes and approach platform:
Portholes shall be provided for all chimneys, stacks and other sources of emission. These shall serve as the sampling points. The sampling point should be located at a distance equal to atleast eight times the stack or duct diameters downstream and two diameters upstream from source of low disturbance such as a Bend, Expansion, Construction Valve, Fitting or Visible Flame for rectangular stacks, the equivalent diameter can be calculated from the following equation.
2 (Length x Width) Equivalent Diameter = ----------------------- (Length + Width)
2. The diameter of the sampling port should not be less than 100 mm dia”. Arrangements should be made so that the porthole is closed firmly during the non sampling period
3. An easily accessible platform to accommodate 3 to 4 persons to conveniently monitor the stack emission from the portholes shall be provided. Arrangements for an Electric Outlet Point of 230 V 15 A with suitable switch control and 3 Pin Point shall be provided at the Porthole location.
4. The ladder shall be provided with adequate safety features so as to approach the monitoring location with ease.
CHIEF/SENIOR ENVIRONMENTAL OFFICERPrinted from XGNPage-5 e_outwardno11463--21/06/2018 e-signed(physical sig
Karnataka State Pollution Control BoardParisara Bhavana,No.49, Church
Street,Bengaluru-560001Tele : 080-25589112/3, 25581383
Fax:080-25586321email id: [email protected]
(This document contains 5 pages including annexure & excluding additional conditions)
Consent No. W-306482Valid upto: 30/06/2021
Consent For Operation(CFO-Air,Water)
Industry Colour: RED Industry Scale: LARGE
SEPTIC
TANK &
SOAK
PITS
UNDERGROUND
SUMP BELOW
DRIVEWAY
(50,000 LTS)
7000mm WIDE DRIVEWAY
6000m
m W
ID
E D
RIV
EW
AY
6000m
m W
ID
E D
RIV
EW
AY
Entry
FIR
E H
YD
RA
NT
R
AIS
ER
62
5 K
VA
D
G S
ET
SOUN
D PR
OOF
ACOU
STIC
12
5 K
VA
D
G S
ET
UP
UP
EXIS
TING
STA
IR C
ASE
FIR
E H
OS
E
CA
BIN
ET
-2
FIRE HOSE
CABINET-3
FIRE HOSE
CABINET-4
150-FIRE HYDRANT-GI
150-FIRE HYDRANT-GI
25
00
53
00
4.1
0M
3600109006000
74
00
10900
2200
22
00
88580
44300
20200 69700
6000
60
00
NO.49,BEHIND ANJANA MINI HALL, MATHIKERE BUS STOP, BANGALORE 54
23371171, 23475699
PLAN SHOWING THE EXISTING FACTORY BUILDING AND
DRG NO. S.B.P.L- 001 - 01/02
PLOT NO.293,
BOMMASANDRA JIGANI LINK ROAD,
JIGANI INDUSTRIAL AREA,
ANEKAL TALUK,
BANGALORE - 560 105.
1 : 200
APPLICANTS SIGNATURE
SYMBOL
DESCRIPTION
4-WAY FIRE BRIGADE INLET
LEGEND:
SCALE:- 1:200
GA
TE
VACANT LAND
70
00
D
DN DN
14-09-2016
40
00
A - MAIN BUILDING
B - SECURITY ROOM
8
9
REVISED MACHINERY LAYOUT FOR
AREA ALREADY APPROVED
FPN / CR - 258 / 2013-014
DATED : 30-04-2014
PRIN
TER
FULL
HEI
GHT
CABI
NETS
VP
-1
Document No.: SBP/EC/18/018/V00 Page 1 of 3
Microbial manufacturing flow chart:
FINAL STERILE FILTRATION
VACUUM CONCENTRATION (IF APPLICABLE)
CONCENTRATION / BUFFER EXCHANGE BY TFF
POLISHING BY CHROMATOGRAPHY
2 STAGES OF CHROMATOGRAPHY PURIFICATION
REFOLDING (IF APPLICABLE)
CELL HOMOGENIZATION
CELL HARVEST OR CLARIFICATION
FULL SCALE BIOREACTOR PROCESS (FERMENTATION)
INOCULUM GENERATION IN SHAKE FLASK &
SMALL FERMENTER
THAWING OF WORKING CELL BANK
MED
IA FILTR
ATION
BUFFER
FILTR
ATION
Document No.: SBP/EC/18/018/V00 Page 2 of 3
Description of Manufacturing Process Upstream Process
The inoculum generation is initiated with thawing of a vial from a cell bank. The cells
from the vial are expanded in conical flasks to obtain the desired amount of inoculum
for starting a 2L- 5L bioreactor. The mode of running the bioreactor is batch / Fed
Batch. The cells are allowed to grow for few hours in batch mode after which feeds of
nutrients like glucose, and salts are fed in the bioreactor at different flow rates.
The bioreactor is harvested at the end of the fermentation, centrifuged and taken for cell
separation.
Cell Harvest clarification: Continuous centrifugation is to separate the cells from the
fermentation media, the pellet of which will be homogenized and followed by depth
filtration/microfiltration.
All the activities that involve cells / cell separation shall be performed in the upstream
area. Cell free /supernatant shall be transferred to DSP for further purification.
Downstream Process
• CAPTURE BY IEX/HCIC CHROMATOGRAPHY: target protein is among thousands
of impurities will be specifically retained over the IEX/HCIC resin leaving impurities
as unbound.
• REFOLDING (AS APPLICABLE): if the protein is in insoluble form, to get back its
3D structure, refolding of protein in a controlled physical and chemical environment
(temperature between 2-25˚C) shall be performed.
• PURIFICATION BY HIC/ ION EXCHANGE CHROMATOGRAPHY: Either Anion
or Cation exchange chromatography is employed for this particular step.
• Polishing Chromatography: SEC or product specific resins shall be used to remove the
related impurities that needs to be separated from the target protein.
• CONCENTRATION / BUFFER EXCHANGE BY TFF: is critical to bring in the
product to the required pre/formulation buffer which ensures the stability.
• Final sterile filtration is required to claim that the product is sterile and is qualified for
fill finish requirement.
Document No.: SBP/EC/18/018/V00 Page 3 of 3
• Samples are collected at different stages during the batch and sent to QC for analytical
testing.
Analytical development:
In the process of biological product development, the most important aspect is the thorough
characterization of the molecules at different stages of process development of drug
substances including in process steps, formulation activities to convert drug substance to
drug product, stability studies etc. Also all the activities related to process characterization
studies for analysis of the product and related impurities shall be performed by existing
analytical development team.
Formulation:
The process of converting drug substance into a stable administrative form for the targeted
use is formulation development. The typical process of formulation development involves,
screening excipients, screen pH, screen the compatibility of stabilizers and find out the
stability of the active ingredient. If the formulation is not stable in the liquid conditions,
then a process of Lyophilisation is used to increase the shelf life of the drug. The Lyo
facility shall be utilized from R & D centre.
Based on the inputs from R & D, pilot batches shall be taken in pilot scale lab using
multipurpose system that can handle vials, PFS, and cartridges.
Document No.: SBP/EC/18/018/V00 Page 1 of 2
1. Water Balance Chart for Existing R&D Raw Water = 6.2KLD
2. Water Balance Chart for Existing PSL
Raw Water = 2.1KLD
Domestic activity (Green belt & Flushing) 0.5KLD
Process (Washing & Others) – 1.6KLD
Domestic sewage– 0.4KLD
Process (Washing & Others) – 1.6KLD
Handed over to CETP of M/s. Pai and Pai Chemicals India private Limited for further
treatment and disposal
Disposed through Septic Tank and Soak pit
Domestic activity (Green belt & Flushing) – 5.5KLD
Process (Washing & Others) – 0.7 KLD
Domestic sewage – 4.4KLD
Process (Washing & Others) – 0.7 KLD
Handed over to CETP of M/s. Pai and Pai Chemicals India private Limited for further
treatment and disposal
Disposed through Septic Tank and Soak pit
Document No.: SBP/EC/18/018/V00 Page 2 of 2
3. Proposed Water Balance Chart
Raw Water = 3.3KLD
4. Total Water Balance Chart
Raw Water = 9.5KLD
Domestic activity – 1.0KLD Process (Washing & Others) – 2.3KLD
Domestic sewage – 1.0KLD Process (Washing & Others) – 2.3KLD
Recycling through in-house ETP 0.5 KLD Flushing
through Septic Tank and Soak pit
Domestic activity –
6.5KLD
Process (Washing & Others) – 3.0KLD
Domestic sewage – 5.4KLD
Process (Washing & Others) – 3.0KLD
Green Belt – 1.8KLD Cooling tower - 1.0KLD
Recycling through in-house ETP
Green Belt – 3.0KLD Cooling tower - 5.4KLD
0.5KLD Recycling through in-house ETP
Document No.: SBP/EC/18/018/V00 Page 1 of 3
List of Raw Materials:
S. No Name of material Make Quantity /
Annum Units
1 Ammonia solutions Merck 276 L
2 Di-ammonium hydrogen phosphate Merck 20133 g
3 Potassium di-hydrogen phosphate Merck 57694.2 g
4 Magnesium sulphate Heptahydrate J.T Baker 16719.6 g
5 D-glucose anhydrous Macron 747.2 Kg
6 IPTG Calbiochem 856.8 g
7 antifoam 204 Sigma 2400 mL
8 Kanamycin acid sulphate Calbiochem 324 g
9 Tryptone BD 111600 g
10 Yeast Extract BD 39600 g
11 Citric acid monohydrate J.T Baker 6500 g
12 EDTA Merck 77.6 Kg
13 Cobalt(ll) chloride hexahydrate Merck 18 g
14 Manganese Chloride Spectrum 36 g
15 Copper (lll) sulphate pentahydrate Merck 10.8 g
16 Boric acid Panreac 10.2 g
17 Sodium Molybdate Merck 12 g
18 Zinc Suphate J.T Baker 40.8 g
19 Ferric Chloride Merck 240 g
20 IPTG Calbiochem 6000 g
21 Silicon antifoam Sigma 9000 mL
Document No.: SBP/EC/18/018/V00 Page 2 of 3
S. No Name of material Make Quantity /
Annum Units
22 Thiamin hydrochloride J.T.Baker 60 g
23 Sodium hydroxide Merck 306 Kg
24 OPA(85%) J.T Baker 6000 mL
25 Iron (lll) Chloride Merck 162 g
26 Zinc Chloride J.T Baker 312 g
27 Calcium chloride dihydrate Spectrum 250 g
28 HCl Merck 125 L
29 NaCl Merck 522 Kg
30 MES 2-(N-morpholino) ethanol Sulfonic acid
Calbiochem 5892 g
31 PMSF Calbiochem 1409.4 g
32 Imidazole Calbiochem 38.28 Kg
33 Sodium Acetate Merck 14.76 Kg
34 Nickel Sulphate Thermo 185.78 Kg
35 Dithiothreitol Sidhhi 9240 g
36 Methanol Merck 81 L
37 Acetic acid glacial Merck 44 L
38 Trifloro Acetic acid Thermo 4875 mL
39 Acetonitrile Merck 1380 L
40 Ethanol Absolute Panreac 466.5 L
41 EK Hangzhou 1320 mL
42 Tris (Hydroxymethyl) amino Methane
Merck 130 Kg
43 Triton x-100 Merck 3.5 Kg
Document No.: SBP/EC/18/018/V00 Page 3 of 3
S. No Name of material Make Quantity /
Annum Units
44 Tween-20 Merck 3.1 Kg
45 L-Cysteine Merck 0.5 Kg
46 Mercaptoethanol Sigma Aldrich
187.5 mL
47 L-Arginine J.T. Baker 15.6 Kg
48 Imidazole Calbiochem (Merck)
7.1 Kg
49 Citraconic anhydride Thermo fisher
300.0 g
50 Trypzean Sigma Aldrich
1500.0 mg
51 N-Propanol Merck 611.9 L
52 Sodium sulphate Merck 39.0 Kg
53 Sodium Phosphate Dibasic Merck 937.5 g
54 L-Glycine Merck 315.0 g
55 Orthophosphoric acid JT Baker 75.0 ml
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006
Revision Date 17.01.2017 Version 1.3
The Safety Data Sheets for catalogue items are available at www.merckgroup.com Page 1 of 18
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 105423
Product name Ammonia solution 28-30% for analysis EMSURE® ACS,Reag. Ph Eur
REACH Registration Number This product is a mixture. REACH Registration Number see section 3.
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Reagent for analysis, Chemical production For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * 8th Floor, Godrej One, Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079 India * Tel: 0091 22 6210 9000
Responsible Department Quality Assurance * Merck Life Science Private Limited *
e-mail: [email protected] *
Tel : +91-2267863131-6
1.4 Emergency telephone number
Please contact the regional company representation in your country.
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture Classification (REGULATION (EC) No 1272/2008)
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006
Catalogue No. 105423 Product name Ammonia solution 28-30% for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com Page 2 of 18
Corrosive to metals, Category 1, H290 Skin corrosion, Category 1B, H314 Specific target organ toxicity - single exposure, Category 3, Respiratory system, H335 Acute aquatic toxicity, Category 1, H400
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008) Hazard pictograms
Signal wordDanger Hazard statementsH290 May be corrosive to metals. H314 Causes severe skin burns and eye damage. H335 May cause respiratory irritation. H400 Very toxic to aquatic life. Precautionary statementsPrevention P273 Avoid release to the environment. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. Response P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006
Catalogue No. 105423 Product name Ammonia solution 28-30% for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com Page 3 of 18
Reduced labelling (≤125 ml)
Hazard pictograms
Signal wordDanger
Hazard statementsH314 Causes severe skin burns and eye damage.
Precautionary statementsP280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.
2.3 Other hazards
None known.
SECTION 3. Composition/information on ingredients
Chemical nature Aqueous ammoniacal solution. 3.1 Substance
Not applicable
3.2 Mixture
Hazardous components (REGULATION (EC) No 1272/2008)Chemical Name (Concentration) CAS-No. Registration number Classification ammonia solution (>= 25 % - < 50 % ) Substance does not meet the criteria for PBT or vPvB according to Regulation (EC) No 1907/2006, Annex XIII.
1336-21-6 *) Corrosive to metals, Category 1, H290 Skin corrosion, Category 1B, H314
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006
Catalogue No. 105423 Product name Ammonia solution 28-30% for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com Page 4 of 18
Specific target organ toxicity - single exposure, Category 3, H335Acute aquatic toxicity, Category 1, H400
*) A registration number is not available for this substance as the substance or its use are exempted from registration according to Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.
For the full text of the H-Statements mentioned in this Section, see Section 16.
SECTION 4. First aid measures
4.1 Description of first aid measures
General adviceFirst aider needs to protect himself.
After inhalation: fresh air. Call in physician.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses.
After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of perforation). Call a physician immediately. Do not attempt to neutralise.
4.2 Most important symptoms and effects, both acute and delayed Irritation and corrosion, bronchitis, Cough, Shortness of breath, gastric pain, Unconsciousness, Bloody vomiting, Nausea, collapse, shock, Convulsions, Lung oedema, death Risk of blindness!
4.3 Indication of any immediate medical attention and special treatment needed No information available.
SECTION 5. Firefighting measures
5.1 Extinguishing media
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006
Catalogue No. 105423 Product name Ammonia solution 28-30% for analysis EMSURE® ACS,Reag. Ph Eur
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Suitable extinguishing mediaUse extinguishing measures that are appropriate to local circumstances and the surrounding environment.
Unsuitable extinguishing mediaFor this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Not combustible. Ammonia solution itself is not flammable, but can form an ignitable ammonia/air-mixture by outgassing. Ambient fire may liberate hazardous vapours. Fire may cause evolution of: nitrogen oxides
5.3 Advice for firefighters
Special protective equipment for firefightersStay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Further informationCool closed containers exposed to fire with water spray. Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapours, aerosols. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.
Advice for emergency responders:
Protective equipment see section 8.
6.2 Environmental precautions
Do not empty into drains.
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006
Catalogue No. 105423 Product name Ammonia solution 28-30% for analysis EMSURE® ACS,Reag. Ph Eur
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6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent and neutralising material (e.g. Chemizorb® OH⁻, Merck Art. No. 101596). Dispose of properly. Clean up affected area.
6.4 Reference to other sectionsIndications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handlingObserve label precautions.
Hygiene measuresImmediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Requirements for storage areas and containersNo metal or light-weight-metal containers.
Storage conditionsTightly closed.
Recommended storage temperature see product label.
7.3 Specific end use(s)Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006
Catalogue No. 105423 Product name Ammonia solution 28-30% for analysis EMSURE® ACS,Reag. Ph Eur
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ammonia solution (1336-21-6)IN OEL Short Term Exposure
Limit (STEL): 35 ppm 27 mg/m³
Time Weighted Average (TWA):
25 ppm 18 mg/m³
8.2 Exposure controls
Engineering measures Technical measures and appropriate working operations should be given priority over the use of personal protective equipment. See section 7.1. Individual protection measures Protective clothing needs to be selected specifically for the workplace, depending on concentrations and quantities of the hazardous substances handled. The chemical resistance of the protective equipment should be enquired at the respective supplier.
Eye/face protectionTightly fitting safety goggles
Hand protection
full contact: Glove material: butyl-rubber Glove thickness: 0.7 mm Break through time: > 480 min
splash contact: Glove material: Nitrile rubber Glove thickness: 0.40 mm Break through time: > 240 min
The protective gloves to be used must comply with the specifications of EC Directive 89/686/EEC and the related standard EN374, for example KCL 898 Butoject® (full contact), KCL 730 Camatril® -Velours (splash contact).
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006
Catalogue No. 105423 Product name Ammonia solution 28-30% for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com Page 8 of 18
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374 with samples of the recommended glove types. This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Other protective equipmentprotective clothing
Respiratory protectionrequired when vapours/aerosols are generated. Recommended Filter type: Filter K (acc. to DIN 3181) for NH₃ The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Environmental exposure controlsDo not empty into drains.
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
Form liquid
Colour colourless
Odour stinging
ammoniacal
Odour Threshold 0.03 - 0.05 ppm
Ammonia
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006
Catalogue No. 105423 Product name Ammonia solution 28-30% for analysis EMSURE® ACS,Reag. Ph Eur
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pH > 12
at 20 °C
strongly alkaline
Melting point ca. -72 °C
Boiling point/boiling range ca. 32 °C
Flash point Not applicable
Evaporation rate No information available.
Flammability (solid, gas) No information available.
Lower explosion limit 15.4 %(V)
Upper explosion limit 33.6 %(V)
Vapour pressure 635 hPa
at 20 °C
Relative vapour density No information available.
Density 0.90 g/cm3 at 20 °C
Relative density No information available.
Water solubility at 20 °C soluble
Partition coefficient: n-octanol/water
log Pow: -1.38 (experimental) (anhydrous substance) Bioaccumulation is not expected.
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006
Catalogue No. 105423 Product name Ammonia solution 28-30% for analysis EMSURE® ACS,Reag. Ph Eur
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Auto-ignition temperature No information available.
Decomposition temperature No information available.
Viscosity, dynamic No information available.
Explosive properties Not classified as explosive.
Oxidizing properties none
9.2 Other data
Minimum ignition energy 380 - 680 mJ
Corrosion May be corrosive to metals.
SECTION 10. Stability and reactivity
10.1 Reactivity
See section 10.3
10.2 Chemical stability
Ammonia solution itself is not flammable, but can form an ignitable ammonia/air-mixture by outgassing.
10.3 Possibility of hazardous reactions
A risk of explosion and/or of toxic gas formation exists with the following substances:
Oxidizing agents, Mercury, Oxygen, silver compounds, nitrogen trichloride, hydrogen peroxide, silver, antimony hydride, halogens, Acids, Calcium, Chlorine, Chlorites, auric salts, perchlorates, sodium hypochlorite, mercury compounds, halogen oxides
Heavy metals, Heavy metal salts, Acid chlorides, Acid anhydrides
Risk of ignition or formation of inflammable gases or vapours with:
Boranes, Boron, Oxides of phosphorus, Nitric acid, silicon compounds, chromium(VI) oxide, chromyl chloride
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006
Catalogue No. 105423 Product name Ammonia solution 28-30% for analysis EMSURE® ACS,Reag. Ph Eur
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Exothermic reaction with:
Acetaldehyde, Acrolein, Barium, boron compounds, Bromine, halogen-halogen compounds, hydrogen bromide, silane, Hydrogen chloride gas, halogen compounds, dimethylsulfate, nitrogen oxides, Fluorine, Hydrogen fluoride, chlorates, carbon dioxide
Ethylene oxide, polymerisable
10.4 Conditions to avoid
Heating.
10.5 Incompatible materials
Aluminium, Lead, Nickel, silver, Zinc, Copper, metal alloys, various metals
10.6 Hazardous decomposition products
in the event of fire: See section 5.
SECTION 11. Toxicological information
11.1 Information on toxicological effects Mixture
Acute oral toxicityLDLO human: 43 mg/kg (29% solution) (RTECS)
Symptoms: gastric pain, Bloody vomiting, If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the oesophagus and the stomach.
If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the oesophagus and the stomach.
Acute inhalation toxicity Symptoms: mucosal irritations, Cough, Shortness of breath, bronchitis, Possible damages:, damage of respiratory tract
Acute dermal toxicityThis information is not available.
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006
Catalogue No. 105423 Product name Ammonia solution 28-30% for analysis EMSURE® ACS,Reag. Ph Eur
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Skin irritationRabbit Result: Severe irritations (29% solution) (RTECS) Dermatitis Necrosis Mixture causes burns.
Eye irritationRabbit Result: Severe irritations (29% solution) (RTECS) Mixture causes serious eye damage. Risk of blindness!
SensitisationThis information is not available.
Germ cell mutagenicityThis information is not available.
CarcinogenicityThis information is not available.
Reproductive toxicityThis information is not available.
TeratogenicityThis information is not available.
Specific target organ toxicity - single exposureMixture may cause respiratory irritation. Target Organs: Respiratory system
Specific target organ toxicity - repeated exposureThis information is not available.
Aspiration hazardThis information is not available.
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006
Catalogue No. 105423 Product name Ammonia solution 28-30% for analysis EMSURE® ACS,Reag. Ph Eur
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11.2 Further information
Systemic effects: Nausea, collapse, shock, Unconsciousness, Convulsions Lung oedema, Possible effects: death Handle in accordance with good industrial hygiene and safety practice. Components
ammonia solution
No information available.
SECTION 12. Ecological information
Mixture
12.1 Toxicity
No information available.
12.2 Persistence and degradability
Biodegradability
Not readily biodegradable.
12.3 Bioaccumulative potential
Partition coefficient: n-octanol/waterlog Pow: -1.38 (experimental) (anhydrous substance) Bioaccumulation is not expected.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessmentSubstance(s) in the mixture do(es) not meet the criteria for PBT or vPvB according to Regulation (EC) No 1907/2006, Annex XIII, or a PBT/vPvB assessment was not conducted.
12.6 Other adverse effects
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006
Catalogue No. 105423 Product name Ammonia solution 28-30% for analysis EMSURE® ACS,Reag. Ph Eur
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Additional ecological informationBiological effects: Harmful effect due to pH shift. Forms toxic and corrosive mixtures with water even if diluted. Discharge into the environment must be avoided. Components ammonia solution
Substance does not meet the criteria for PBT or vPvB according to Regulation (EC) No 1907/2006, Annex XIII.
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006
Catalogue No. 105423 Product name Ammonia solution 28-30% for analysis EMSURE® ACS,Reag. Ph Eur
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SECTION 13. Disposal considerations
Waste treatment methodsWaste material must be disposed of in accordance with the national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself. See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 UN number UN 2672
14.2 Proper shipping name AMMONIA SOLUTION
14.3 Class 8
14.4 Packing group III
14.5 Environmentally hazardous yes
14.6 Special precautions for user
yes
Tunnel restriction code E
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)
14.1 UN number UN 2672
14.2 Proper shipping name AMMONIA SOLUTION
14.3 Class 8
14.4 Packing group III
14.5 Environmentally hazardous yes
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006
Catalogue No. 105423 Product name Ammonia solution 28-30% for analysis EMSURE® ACS,Reag. Ph Eur
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14.6 Special precautions for user
no
Sea transport (IMDG)
14.1 UN number UN 2672
14.2 Proper shipping name AMMONIA SOLUTION
14.3 Class 8
14.4 Packing group III
14.5 Environmentally hazardous yes
14.6 Special precautions for user
yes
EmS F-A S-B
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National legislation
Storage class 8B
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Full text of H-Statements referred to under sections 2 and 3.
H290 May be corrosive to metals. H314 Causes severe skin burns and eye damage. H335 May cause respiratory irritation. H400 Very toxic to aquatic life.
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006
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Training advice Provide adequate information, instruction and training for operators. Labelling
Hazard pictograms
Signal wordDanger Hazard statementsH290 May be corrosive to metals. H314 Causes severe skin burns and eye damage. H335 May cause respiratory irritation. H400 Very toxic to aquatic life. Precautionary statementsPrevention P273 Avoid release to the environment. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. Response P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006
Catalogue No. 105423 Product name Ammonia solution 28-30% for analysis EMSURE® ACS,Reag. Ph Eur
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The information contained herein is based on the present state of our knowledge. It characterises the product with regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006
Date of issue: 06.05.2014 Version 1.0
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 8
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 101207
Product name di-Ammonium hydrogen phosphate for analysis EMSURE®
ACS,Reag. Ph Eur
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.
CAS-No. 7783-28-0
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Reagent for analysis
For additional information on uses please refer to the Merck Chemicals
portal (www.merck-chemicals.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * 8th Floor, Godrej One,
Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079
India * Tel: 0091 22 6210 9000
Responsible Department Quality Assurance * Merck Life Science Private Limited *
e-mail: [email protected] *
Tel : +91-2267863131-6
1.4 Emergency telephone
number
Please contact the regional company representation in your country.
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
This substance is not classified as dangerous according to European Union legislation.
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
2.3 Other hazards
None known.
SECTION 3. Composition/information on ingredients
3.1 Substance
Formula (NH₄)₂HPO₄ H₉N₂O₄P (Hill)
EC-No. 231-987-8
Molar mass 132.05 g/mol
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 101207
Product name di-Ammonium hydrogen phosphate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 8
For the full text of the H-Statements mentioned in this Section, see Section 16.
Remarks No disclosure requirement according to Regulation (EC) No.
1907/2006
3.2 Mixture
not applicable
SECTION 4. First aid measures
4.1 Description of first aid measures
After inhalation: fresh air.
After skin contact: wash off with plenty of water. Remove contaminated clothing.
After eye contact: rinse out with plenty of water.
After swallowing: make victim drink water (two glasses at most). Consult doctor if feeling unwell.
4.2 Most important symptoms and effects, both acute and delayed
Diarrhoea
The following applies to ammonium salts in general: after swallowing: local irritation symptoms,
nausea, vomiting, diarrhoea. Systemic effect: after the uptake of very large qantities: drop in
blood pressure, collapse, CNS disorders, spasms, narcotic conditions, respiratory paralysis,
haemolysis.
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SECTION 5. Firefighting measures
5.1 Extinguishing media
Suitable extinguishing mediaUse extinguishing measures that are appropriate to local circumstances and the surrounding
environment.
Unsuitable extinguishing mediaFor this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Not combustible.
Ambient fire may liberate hazardous vapours.
Fire may cause evolution of:
Oxides of phosphorus, nitrogen oxides
5.3 Advice for firefighters
Special protective equipment for firefightersIn the event of fire, wear self-contained breathing apparatus.
Further informationPrevent fire extinguishing water from contaminating surface water or the ground water system.
Suppress (knock down) gases/vapours/mists with a water spray jet.
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 101207
Product name di-Ammonium hydrogen phosphate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 8
Advice for non-emergency personnel: Avoid inhalation of dusts. Evacuate the danger area,
observe emergency procedures, consult an expert.
Advice for emergency responders: Protective equipment see section 8.
6.2 Environmental precautions
Do not empty into drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills.
Observe possible material restrictions (see sections 7 and 10).
Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.
6.4 Reference to other sections
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handlingObserve label precautions.
Hygiene measuresChange contaminated clothing. Wash hands after working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditionsTightly closed. Dry.
Recommended storage temperature see product label.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
Contains no substances with occupational exposure limit values.
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Eye/face protectionSafety glasses
Hand protection
full contact:
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 101207
Product name di-Ammonium hydrogen phosphate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 4 of 8
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
splash contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 741 Dermatril® L (full contact),
KCL 741 Dermatril® L (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet, supplied by us
and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Respiratory protectionrequired when dusts are generated.
Recommended Filter type: Filter P 1 (acc. to DIN 3181) for solid particles of inert substances
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
Environmental exposure controls
Do not empty into drains.
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
Form solid
Colour white
Odour stinging
Odour Threshold No information available.
pH 7.6 - 8.2
at 100 g/l
20 °C
Melting point (decomposition)
Boiling point/boiling range not applicable
Flash point does not flash
Evaporation rate No information available.
Flammability (solid, gas) No information available.
Lower explosion limit not applicable
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 101207
Product name di-Ammonium hydrogen phosphate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 5 of 8
Upper explosion limit not applicable
Vapour pressure No information available.
Relative vapour density No information available.
Density 1.619 g/cm³
at 20 °C
Relative density No information available.
Water solubility 690 g/l
at 20 °C
Partition coefficient: n-
octanol/water
log Pow: -2.85
(calculated)
(Lit.) Bioaccumulation is not expected.
Auto-ignition temperature No information available.
Decomposition temperature > 100 °C
Viscosity, dynamic No information available.
Explosive properties Not classified as explosive.
Oxidizing properties none
9.2 Other data
Ignition temperature not combustible
Bulk density ca.800 - 1,000 kg/m³
SECTION 10. Stability and reactivity
10.1 Reactivity
See section 10.3
10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.3 Possibility of hazardous reactions
Risk of explosion with:
sodium hypochlorite
10.4 Conditions to avoid
Strong heating.
10.5 Incompatible materials
no information available
10.6 Hazardous decomposition products
in the event of fire: See section 5.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 101207
Product name di-Ammonium hydrogen phosphate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 6 of 8
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Acute oral toxicityLD50 rat: 6,500 mg/kg (IUCLID)
Acute inhalation toxicityThis information is not available.
Acute dermal toxicityLD50 rabbit: > 7,950 mg/kg (IUCLID)
Skin irritationThis information is not available.
Eye irritationThis information is not available.
SensitisationThis information is not available.
Germ cell mutagenicityThis information is not available.
CarcinogenicityThis information is not available.
Reproductive toxicityThis information is not available.
TeratogenicityThis information is not available.
Specific target organ toxicity - single exposureThis information is not available.
Specific target organ toxicity - repeated exposureThis information is not available.
Aspiration hazardThis information is not available.
11.2 Further information
After uptake of large quantities:
Diarrhoea, disturbed electrolyte balance.
The following applies to ammonium salts in general: after swallowing: local irritation symptoms,
nausea, vomiting, diarrhoea. Systemic effect: after the uptake of very large qantities: drop in
blood pressure, collapse, CNS disorders, spasms, narcotic conditions, respiratory paralysis,
haemolysis.
Handle in accordance with good industrial hygiene and safety practice.
SECTION 12. Ecological information
12.1 Toxicity
Toxicity to fishLC50 Pimephales promelas (fathead minnow): 155 mg/l; 96 h (IUCLID)
12.2 Persistence and degradability
Biodegradability
The methods for determining the biological degradability are not applicable to inorganic
substances.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 101207
Product name di-Ammonium hydrogen phosphate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 7 of 8
12.3 Bioaccumulative potential
Partition coefficient: n-octanol/waterlog Pow: -2.85
(calculated)
(Lit.) Bioaccumulation is not expected.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
Substance does not meet the criteria for PBT or vPvB according to Regulation (EC) No
1907/2006, Annex XIII.
12.6 Other adverse effects
Discharge into the environment must be avoided.
SECTION 13. Disposal considerations
Waste treatment methodsWaste material must be disposed of in accordance with the Directive on waste 2008/98/EC as
well as other national and local regulations. Leave chemicals in original containers. No mixing
with other waste. Handle uncleaned containers like the product itself.
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Sea transport (IMDG)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National legislation
Storage class 10 - 13
15.2 Chemical Safety Assessment
A Chemical Safety Assessment has been carried out according to regulation (EC) No.
1907/2006 (REACH) for this substance.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 101207
Product name di-Ammonium hydrogen phosphate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 8 of 8
SECTION 16. Other information
Training advice
Provide adequate information, instruction and training for operators.
Labelling (67/548/EEC or 1999/45/EC)
The product does not need to be labelled in accordance with EC directives or respective national
laws.
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
The information contained herein is based on the present state of our knowledge. It characterises the product with regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Revision Date 13.10.2016 Version 1.2
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 12
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 104873
Product name Potassium dihydrogen phosphate for analysis EMSURE® ISO
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.
CAS-No. 7778-77-0
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Reagent for analysis
For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * 8th Floor, Godrej One,
Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079
India * Tel: 0091 22 6210 9000
Responsible Department Quality Assurance * Merck Life Science Private Limited *
e-mail: [email protected] *
Tel : +91-2267863131-6
1.4 Emergency telephone
number
Please contact the regional company representation in your country.
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
This substance is not classified as dangerous according to European Union legislation.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 104873
Product name Potassium dihydrogen phosphate for analysis EMSURE® ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 12
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Precautionary statements
Prevention
P260 Do not breathe dust.
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
2.3 Other hazards
None known.
SECTION 3. Composition/information on ingredients
3.1 Substance
Formula KH₂PO₄ H₂KO₄P (Hill)
EC-No. 231-913-4
Molar mass 136.08 g/mol
Remarks No disclosure requirement according to Regulation (EC) No.
1907/2006.
3.2 Mixture
Not applicable
SECTION 4. First aid measures
4.1 Description of first aid measures
After inhalation: fresh air.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower.
After eye contact: rinse out with plenty of water. Remove contact lenses.
After swallowing: make victim drink water (two glasses at most). Consult doctor if feeling unwell.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 104873
Product name Potassium dihydrogen phosphate for analysis EMSURE® ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 12
4.2 Most important symptoms and effects, both acute and delayed
irritant effects, gastric pain, Diarrhoea, Nausea, Vomiting, Discomfort
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SECTION 5. Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Use extinguishing measures that are appropriate to local circumstances and the surrounding
environment.
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Not combustible.
Ambient fire may liberate hazardous vapours.
Fire may cause evolution of:
Oxides of phosphorus
5.3 Advice for firefighters
Special protective equipment for firefighters
In the event of fire, wear self-contained breathing apparatus.
Further information
Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing
water from contaminating surface water or the ground water system.
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid inhalation of dusts. Evacuate the danger area,
observe emergency procedures, consult an expert.
Advice for emergency responders: Protective equipment see section 8.
6.2 Environmental precautions
Do not empty into drains.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 104873
Product name Potassium dihydrogen phosphate for analysis EMSURE® ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 4 of 12
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills.
Observe possible material restrictions (see sections 7 and 10).
Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.
6.4 Reference to other sections
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handling
Observe label precautions.
Hygiene measures
Change contaminated clothing. Wash hands after working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed. Dry.
Recommended storage temperature see product label.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
Contains no substances with occupational exposure limit values.
Contains no substances with occupational exposure limit values.
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 104873
Product name Potassium dihydrogen phosphate for analysis EMSURE® ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 5 of 12
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Eye/face protection
Safety glasses
Hand protection
full contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
splash contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 741 Dermatril® L (full contact),
KCL 741 Dermatril® L (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Respiratory protection
required when dusts are generated.
Recommended Filter type: Filter P 1 (acc. to DIN 3181) for solid particles of inert substances
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
Environmental exposure controls
Do not empty into drains.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 104873
Product name Potassium dihydrogen phosphate for analysis EMSURE® ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 6 of 12
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
Form solid
Colour colourless
Odour odourless
Odour Threshold Not applicable
pH 4.2 - 4.6
at 20 g/l
20 °C
Melting point ca. 253 °C
(decomposition)
Boiling point/boiling range Not applicable, (decomposition)
Flash point does not flash
Evaporation rate No information available.
Flammability (solid, gas) No information available.
Lower explosion limit Not applicable
Upper explosion limit Not applicable
Vapour pressure No information available.
Relative vapour density No information available.
Density 2.33 g/cm3
at 21.5 °C
Method: Tested according to Annex V of Directive 67/548/EEC.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 104873
Product name Potassium dihydrogen phosphate for analysis EMSURE® ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 7 of 12
Relative density No information available.
Water solubility 208 g/l
at 20.0 °C
Method: Tested according to Annex V of Directive 67/548/EEC.
soluble
Partition coefficient: n-
octanol/water
No information available.
Auto-ignition temperature No information available.
Decomposition temperature No information available.
Viscosity, dynamic No information available.
Explosive properties Not classified as explosive.
Oxidizing properties none
9.2 Other data
Ignition temperature not combustible
Bulk density ca.1,200 kg/m3
Particle size Mean particle size
< 0.045 mm
SECTION 10. Stability and reactivity
10.1 Reactivity
See section 10.3
10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.3 Possibility of hazardous reactions
Violent reactions possible with:
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 104873
Product name Potassium dihydrogen phosphate for analysis EMSURE® ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 8 of 12
Strong oxidizing agents, Bases, acids
10.4 Conditions to avoid
Strong heating (decomposition).
10.5 Incompatible materials
no information available
10.6 Hazardous decomposition products
in the event of fire: See section 5.
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Acute oral toxicity
LDLO Rat: 4,640 mg/kg
Symptoms: Nausea, Vomiting, gastric pain, Diarrhoea, Discomfort
(RTECS)
LD50 Rat: > 2,000 mg/kg
OECD Test Guideline 420
The value is given in analogy to the following substances: dipotassium hydrogen phosphate
Acute inhalation toxicity
LC50 Rat: > 0.83 mg/l; 4 h ; dust/mist
OECD Test Guideline 403
The value is given in analogy to the following substances: (highest concentration to be prepared)
sodium dihydrogen phosphate
Acute dermal toxicity
LD50 Rabbit: > 4,640 mg/kg
(RTECS)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 104873
Product name Potassium dihydrogen phosphate for analysis EMSURE® ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 9 of 12
Skin irritation
Rabbit
Result: No skin irritation
Draize Test
(ECHA)
Eye irritation
Rabbit
Result: No eye irritation
Draize Test
(ECHA)
Sensitisation
Sensitisation test: Mouse
Result: Does not cause skin sensitisation.
Method: OECD Test Guideline 429
The value is given in analogy to the following substances: sodium dihydrogen phosphate
Germ cell mutagenicity
This information is not available.
Carcinogenicity
This information is not available.
Reproductive toxicity
This information is not available.
Teratogenicity
This information is not available.
Specific target organ toxicity - single exposure
This information is not available.
Specific target organ toxicity - repeated exposure
This information is not available.
Aspiration hazard
This information is not available.
11.2 Further information
Hazardous properties cannot be excluded but are unlikely when the product is handled
appropriately.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 104873
Product name Potassium dihydrogen phosphate for analysis EMSURE® ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 10 of 12
Inhalation of the dusts should be avoided as even inert dusts may impair respiratory organ
functions.
Handle in accordance with good industrial hygiene and safety practice.
SECTION 12. Ecological information
12.1 Toxicity
Toxicity to fish
LC0 Leuciscus idus (Golden orfe): ca. 900 mg/l; 48 h
(IUCLID)
Toxicity to bacteria
static test EC50 activated sludge: > 1,000 mg/l; 3 h
OECD Test Guideline 209
The value is given in analogy to the following substances: dipotassium hydrogen phosphate
12.2 Persistence and degradability
No information available.
12.3 Bioaccumulative potential
No information available.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.
12.6 Other adverse effects
Additional ecological information
Depending on the concentration, phosphates may contribute to the eutrophication of water
supplies.
Discharge into the environment must be avoided.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 104873
Product name Potassium dihydrogen phosphate for analysis EMSURE® ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 11 of 12
SECTION 13. Disposal considerations
Waste treatment methods
Waste material must be disposed of in accordance with the national and local regulations. Leave
chemicals in original containers. No mixing with other waste. Handle uncleaned containers like
the product itself.
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Sea transport (IMDG)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National legislation
Storage class 10 - 13
15.2 Chemical Safety Assessment
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 104873
Product name Potassium dihydrogen phosphate for analysis EMSURE® ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 12 of 12
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Training advice
Provide adequate information, instruction and training for operators.
Labelling
Precautionary statements
Prevention
P260 Do not breathe dust.
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
MATERIAL SAFETY DATA SHEETMATERIAL SAFETY DATA SHEETMATERIAL SAFETY DATA SHEETMATERIAL SAFETY DATA SHEET
1111. . . . Product and Company IdentificationProduct and Company IdentificationProduct and Company IdentificationProduct and Company IdentificationMaterial nameMaterial nameMaterial nameMaterial name MAGNESIUM SULFATE HEPTAHYDRATEMAGNESIUM SULFATE HEPTAHYDRATEMAGNESIUM SULFATE HEPTAHYDRATEMAGNESIUM SULFATE HEPTAHYDRATEVersion #Version #Version #Version # 02Revision dateRevision dateRevision dateRevision date 08-29-2011CAS #CAS #CAS #CAS # 10034-99-8Product CodesProduct CodesProduct CodesProduct Codes J.T.Baker: 2500, 2504, 2505J.T.Baker: 2500, 2504, 2505J.T.Baker: 2500, 2504, 2505J.T.Baker: 2500, 2504, 2505
Macron: 26806, 4200, 5099, 5691, 6046, 6066, 7778Macron: 26806, 4200, 5099, 5691, 6046, 6066, 7778Macron: 26806, 4200, 5099, 5691, 6046, 6066, 7778Macron: 26806, 4200, 5099, 5691, 6046, 6066, 7778Synonym(s)Synonym(s)Synonym(s)Synonym(s) Magnesium sulfate (1:1) heptahydrate; Epsom salts; sulfuric acid, magnesium salt (1:1),
heptahydrate; Magnesium sulfate, 7- hydrate
Customer ServiceCustomer ServiceCustomer ServiceCustomer Service 855-282-686724 Hour Emergency24 Hour Emergency24 Hour Emergency24 Hour Emergency 908-859-2151ChemtrecChemtrecChemtrecChemtrec 800-424-9300
ManufacturerManufacturerManufacturerManufacturerAddressAddressAddressAddress
Avantor Performance Materials, Inc.3477 Corporate Parkway
Center Valley, PA 18034US
Suite #200
2222. . . . Hazards IdentificationHazards IdentificationHazards IdentificationHazards IdentificationEmergency overviewEmergency overviewEmergency overviewEmergency overview CAUTION
Product dust may be irritating to eyes, skin and respiratory system.OSHA regulatory statusOSHA regulatory statusOSHA regulatory statusOSHA regulatory status This material is not considered hazardous by the OSHA Hazard Communication Standard, OSHA
29 CFR 1910.1200.
Potential health effectsPotential health effectsPotential health effectsPotential health effectsRoutes of exposureRoutes of exposureRoutes of exposureRoutes of exposure Inhalation. Skin contact. Eye contact. Ingestion.EyesEyesEyesEyes Dust or powder may irritate eye tissue. If irritation should occur, it is expected to be transient.SkinSkinSkinSkin Dust or powder may irritate the skin.InhalationInhalationInhalationInhalation Inhalation of dusts may cause respiratory irritation.IngestionIngestionIngestionIngestion Expected to be a low ingestion hazard. May cause temporary irritation of the throat, stomach, and
gastrointestinal tract.Chronic effectsChronic effectsChronic effectsChronic effects None known.Potential environmental effectsPotential environmental effectsPotential environmental effectsPotential environmental effects The product components are not classified as environmentally hazardous. However, this does not
exclude the possibility that large or frequent spills can have a harmful or damaging effect on theenvironment.
Non-hazardous componentsNon-hazardous componentsNon-hazardous componentsNon-hazardous components CAS #CAS #CAS #CAS # PercentPercentPercentPercent
3333. . . . Composition Composition Composition Composition / / / / Information on IngredientsInformation on IngredientsInformation on IngredientsInformation on Ingredients
10034-99-8 98 - 100MAGNESIUM SULFATE HEPTAHYDRATE
Composition commentsComposition commentsComposition commentsComposition comments CAS # 10034-99-8 can be described by the CAS # 7487-88-9.
4444. . . . First Aid MeasuresFirst Aid MeasuresFirst Aid MeasuresFirst Aid MeasuresFirst aid proceduresFirst aid proceduresFirst aid proceduresFirst aid procedures
Eye contactEye contactEye contactEye contact Any material that contacts the eye should be washed out immediately with water. If easy to do,remove contact lenses. Get medical attention if irritation develops and persists.
Skin contactSkin contactSkin contactSkin contact Wash off with soap and water. Get medical attention if irritation develops and persists.InhalationInhalationInhalationInhalation Move to fresh air. Treat symptomatically. Get medical attention if symptoms persist.
Material name: MAGNESIUM SULFATE HEPTAHYDRATEMSDS ID: M0234 Version #: 02 Revision date: 08-29-2011
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IngestionIngestionIngestionIngestion Seek medical advice.Notes to physicianNotes to physicianNotes to physicianNotes to physician Treat symptomatically.General adviceGeneral adviceGeneral adviceGeneral advice Ensure that medical personnel are aware of the material(s) involved, and take precautions to
protect themselves. Show this safety data sheet to the doctor in attendance.
5555. . . . Fire Fighting MeasuresFire Fighting MeasuresFire Fighting MeasuresFire Fighting MeasuresFlammable propertiesFlammable propertiesFlammable propertiesFlammable properties This product is not flammable.
Extinguishing mediaExtinguishing mediaExtinguishing mediaExtinguishing mediaSuitable extinguishingSuitable extinguishingSuitable extinguishingSuitable extinguishingmediamediamediamedia
Use extinguishing measures that are appropriate to local circumstances and the surroundingenvironment.
Unsuitable extinguishingUnsuitable extinguishingUnsuitable extinguishingUnsuitable extinguishingmediamediamediamedia
None known.
Protection of firefightersProtection of firefightersProtection of firefightersProtection of firefightersProtective equipment andProtective equipment andProtective equipment andProtective equipment andprecautions for firefightersprecautions for firefightersprecautions for firefightersprecautions for firefighters
Firefighters should wear full protective gear. Wear full protective clothing, including helmet,self-contained positive pressure or pressure demand breathing apparatus, protective clothing andface mask.
Special protective equipment forSpecial protective equipment forSpecial protective equipment forSpecial protective equipment forfire-fightersfire-fightersfire-fightersfire-fighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH(approved or equivalent) and full protective gear.
6666. . . . Accidental Release MeasuresAccidental Release MeasuresAccidental Release MeasuresAccidental Release MeasuresPersonal precautionsPersonal precautionsPersonal precautionsPersonal precautions Keep unnecessary personnel away. Keep upwind. Ventilate the area. Avoid inhalation of dust
from the spilled material. Do not touch damaged containers or spilled material unless wearingappropriate protective clothing.
Environmental precautionsEnvironmental precautionsEnvironmental precautionsEnvironmental precautions Prevent further leakage or spillage if safe to do so.Methods for containmentMethods for containmentMethods for containmentMethods for containment If sweeping of a contaminated area is necessary use a dust suppressant agent which does not
react with the product. Prevent entry into waterways, sewer, basements or confined areas.Methods for cleaning upMethods for cleaning upMethods for cleaning upMethods for cleaning up Avoid dust formation.
Small Spills: Sweep up or vacuum up spillage and collect in suitable container for disposal.
Large Spills: Collect dust or particulates using a vacuum cleaner with a HEPA filter. Reduceairborne dust and prevent scattering by moistening with water.
Never return spills in original containers for re-use. Clean contaminated surface thoroughly. Cleanup in accordance with all applicable regulations.
7777. . . . Handling and StorageHandling and StorageHandling and StorageHandling and StorageHandlingHandlingHandlingHandling Keep formation of airborne dusts to a minimum. Avoid breathing dust. Avoid contact with eyes,
skin, and clothing. Use only with adequate ventilation. Wash thoroughly after handling. SeeSection 8 of the MSDS for Personal Protective Equipment.
StorageStorageStorageStorage Keep container tightly closed. Store in a well-ventilated place.
8888. . . . Exposure Controls Exposure Controls Exposure Controls Exposure Controls / / / / Personal ProtectionPersonal ProtectionPersonal ProtectionPersonal ProtectionEngineering controlsEngineering controlsEngineering controlsEngineering controls Ventilation should be sufficient to effectively remove and prevent buildup of any dusts or fumes
that may be generated during handling or thermal processing. If engineering measures are notsufficient to maintain concentrations of dust particulates below the OEL, suitable respiratoryprotection must be worn.
Personal protective equipmentPersonal protective equipmentPersonal protective equipmentPersonal protective equipmentEye / face protectionEye / face protectionEye / face protectionEye / face protection Use tight fitting goggles if dust is generated.Skin protectionSkin protectionSkin protectionSkin protection Wear appropriate clothing to prevent repeated or prolonged skin contact.Respiratory protectionRespiratory protectionRespiratory protectionRespiratory protection Wear respirator if there is dust formation.General hygeineGeneral hygeineGeneral hygeineGeneral hygeineconsiderationsconsiderationsconsiderationsconsiderations
Provide eyewash station and safety shower. Always observe good personal hygiene measures,such as washing after handling the material and before eating, drinking, and/or smoking.Routinely wash work clothing and protective equipment to remove contaminants.
Material name: MAGNESIUM SULFATE HEPTAHYDRATEMSDS ID: M0234 Version #: 02 Revision date: 08-29-2011
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9999. . . . Physical & Chemical PropertiesPhysical & Chemical PropertiesPhysical & Chemical PropertiesPhysical & Chemical PropertiesAppearanceAppearanceAppearanceAppearance Powder. Crystalline.
ColorColorColorColor Colorless to white.
OdorOdorOdorOdor Odorless.
Odor thresholdOdor thresholdOdor thresholdOdor threshold Not available.
Physical statePhysical statePhysical statePhysical state Solid.
FormFormFormForm Crystalline powder.
Flash pointFlash pointFlash pointFlash point Not available.
Evaporation rateEvaporation rateEvaporation rateEvaporation rate Not available.
Flammability limits in air, upper,Flammability limits in air, upper,Flammability limits in air, upper,Flammability limits in air, upper,% by volume% by volume% by volume% by volume
Not available.
Flammability limits in air, lower,Flammability limits in air, lower,Flammability limits in air, lower,Flammability limits in air, lower,% by volume% by volume% by volume% by volume
Not available.
Vapor densityVapor densityVapor densityVapor density Not available.
Specific gravitySpecific gravitySpecific gravitySpecific gravity 1.67
Relative densityRelative densityRelative densityRelative density Not available.
Solubility (water)Solubility (water)Solubility (water)Solubility (water) Soluble
Partition coefficientPartition coefficientPartition coefficientPartition coefficient(n-octanol/water)(n-octanol/water)(n-octanol/water)(n-octanol/water)
Not available
Auto-ignition temperatureAuto-ignition temperatureAuto-ignition temperatureAuto-ignition temperature Not available.
Molecular weightMolecular weightMolecular weightMolecular weight 246.47 g/mol
Molecular formulaMolecular formulaMolecular formulaMolecular formula Mg-O4-S.7H2O
10101010. . . . Chemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical stabilityChemical stabilityChemical stabilityChemical stability Stable under normal temperature conditions.Conditions to avoidConditions to avoidConditions to avoidConditions to avoid Incompatible materials.Incompatible materialsIncompatible materialsIncompatible materialsIncompatible materials Strong oxidizing agents.Hazardous decompositionHazardous decompositionHazardous decompositionHazardous decompositionproductsproductsproductsproducts
Sulfur oxides. May include oxides of Magnesium.
Possibility of hazardousPossibility of hazardousPossibility of hazardousPossibility of hazardousreactionsreactionsreactionsreactions
Hazardous polymerization does not occur.
11111111. . . . Toxicological InformationToxicological InformationToxicological InformationToxicological InformationSensitizationSensitizationSensitizationSensitization Not a skin sensitizer.
Acute effectsAcute effectsAcute effectsAcute effects Low hazard for usual industrial or commercial handling.
Local effectsLocal effectsLocal effectsLocal effects May cause eye irritation. May cause skin irritation. May cause irritation to the respiratory system.
Chronic effectsChronic effectsChronic effectsChronic effects None known.
CarcinogenicityCarcinogenicityCarcinogenicityCarcinogenicity This product is not considered to be a carcinogen by IARC, ACGIH, NTP, or OSHA.
Skin corrosion/irritationSkin corrosion/irritationSkin corrosion/irritationSkin corrosion/irritation May irritate and cause redness and pain.
EpidemiologyEpidemiologyEpidemiologyEpidemiology No epidemiological data is available for this product.
MutagenicityMutagenicityMutagenicityMutagenicity No data available to indicate product or any components present at greater than 0.1% aremutagenic or genotoxic.
Neurological effectsNeurological effectsNeurological effectsNeurological effects None known.
Reproductive effectsReproductive effectsReproductive effectsReproductive effects Contains no ingredient listed as toxic to reproduction
TeratogenicityTeratogenicityTeratogenicityTeratogenicity No data available to indicate product or any components present at greater than 0.1% may causebirth defects.
Symptoms and targetSymptoms and targetSymptoms and targetSymptoms and targetorgansorgansorgansorgans
Mild eye irritation.
Material name: MAGNESIUM SULFATE HEPTAHYDRATEMSDS ID: M0234 Version #: 02 Revision date: 08-29-2011
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Ecotoxicological dataEcotoxicological dataEcotoxicological dataEcotoxicological data
12121212. . . . Ecological InformationEcological InformationEcological InformationEcological Information
ProductProductProductProduct Test ResultsTest ResultsTest ResultsTest Results
LC50 Fathead minnow (Pimephales promelas): 2610 mg/l96.00 hours
MAGNESIUM SULFATE HEPTAHYDRATE (10034-99-8)
EcotoxicityEcotoxicityEcotoxicityEcotoxicity This product has no known eco-toxicological effects.
Environmental effectsEnvironmental effectsEnvironmental effectsEnvironmental effects Ecological injuries are not known or expected under normal use. An environmental hazard cannotbe excluded in the event of unprofessional handling or disposal.
Aquatic toxicityAquatic toxicityAquatic toxicityAquatic toxicity This material is not expected to be harmful to aquatic life.
Persistence andPersistence andPersistence andPersistence anddegradabilitydegradabilitydegradabilitydegradability
The product is not expected to be biodegradable.
Partition coefficientPartition coefficientPartition coefficientPartition coefficient(n-octanol/water)(n-octanol/water)(n-octanol/water)(n-octanol/water)
Not available
13131313. . . . Disposal ConsiderationsDisposal ConsiderationsDisposal ConsiderationsDisposal ConsiderationsDisposal instructionsDisposal instructionsDisposal instructionsDisposal instructions Dispose of contents/container in accordance with local/regional/national/international regulations.
Incinerate the material under controlled conditions in an approved incinerator.Contaminated packagingContaminated packagingContaminated packagingContaminated packaging Offer rinsed packaging material to local recycling facilities. Since emptied containers retain
product residue, follow label warnings even after container is emptied.
14141414. . . . Transport InformationTransport InformationTransport InformationTransport InformationDOTDOTDOTDOTNot regulated as dangerous goods.
IATAIATAIATAIATANot regulated as dangerous goods.
IMDGIMDGIMDGIMDGNot regulated as dangerous goods.
15151515. . . . Regulatory InformationRegulatory InformationRegulatory InformationRegulatory InformationUS federal regulationsUS federal regulationsUS federal regulationsUS federal regulations This product is not known to be a "Hazardous Chemical" as defined by the OSHA Hazard
Communication Standard, 29 CFR 1910.1200.
This product is not listed on the U.S. EPA TSCA Inventory. Under TSCA, hydrates areconsidered mixtures of their anhydrous salt and water. Accordingly, the anhydrous form issubject to TSCA reporting requirements.
CERCLA (Superfund) reportable quantityCERCLA (Superfund) reportable quantityCERCLA (Superfund) reportable quantityCERCLA (Superfund) reportable quantityNone
Superfund Amendments and Reauthorization Act of 1986 (SARA)Superfund Amendments and Reauthorization Act of 1986 (SARA)Superfund Amendments and Reauthorization Act of 1986 (SARA)Superfund Amendments and Reauthorization Act of 1986 (SARA)Hazard categoriesHazard categoriesHazard categoriesHazard categories Immediate Hazard - No
Delayed Hazard - NoFire Hazard - NoPressure Hazard - NoReactivity Hazard - No
Section 311 hazardousSection 311 hazardousSection 311 hazardousSection 311 hazardouschemicalchemicalchemicalchemical
No
Food and Drug AdministrationFood and Drug AdministrationFood and Drug AdministrationFood and Drug Administration(FDA)(FDA)(FDA)(FDA)
Total food additiveDirect food additiveGRAS food additive
Inventory statusInventory statusInventory statusInventory statusCountryCountryCountryCountry((((ssss) ) ) ) or regionor regionor regionor region Inventory nameInventory nameInventory nameInventory name On inventory On inventory On inventory On inventory ((((yesyesyesyes////nononono)*)*)*)*
YesAustralia Australian Inventory of Chemical Substances (AICS)YesCanada Domestic Substances List (DSL)
Material name: MAGNESIUM SULFATE HEPTAHYDRATEMSDS ID: M0234 Version #: 02 Revision date: 08-29-2011
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CountryCountryCountryCountry((((ssss) ) ) ) or regionor regionor regionor region Inventory nameInventory nameInventory nameInventory name On inventory On inventory On inventory On inventory ((((yesyesyesyes////nononono)*)*)*)*NoCanada Non-Domestic Substances List (NDSL)
YesChina Inventory of Existing Chemical Substances in China (IECSC)NoEurope European Inventory of Existing Commercial Chemical
Substances (EINECS)NoEurope European List of Notified Chemical Substances (ELINCS)
YesJapan Inventory of Existing and New Chemical Substances (ENCS)NoKorea Existing Chemicals List (ECL)
YesNew Zealand New Zealand InventoryYesPhilippines Philippine Inventory of Chemicals and Chemical Substances
(PICCS)NoUnited States & Puerto Rico Toxic Substances Control Act (TSCA) Inventory
*A "Yes" indicates that all components of this product comply with the inventory requirements administered by the governing country(s)
State regulationsState regulationsState regulationsState regulations This product does not contain a chemical known to the State of California to cause cancer, birthdefects or other reproductive harm.
Saf-T-DataSaf-T-DataSaf-T-DataSaf-T-Data Health: 1 - SlightFlammability: 0 - NoneReactivity: 1 - SlightContact: 1 - SlightLab Protective Equip: C - GOGGLES; LAB COAT; PROPER GLOVESStorage Color Code: G - Green (General Storage)
16161616. . . . Labeling InfoLabeling InfoLabeling InfoLabeling InfoLabel Hazard WarningLabel Hazard WarningLabel Hazard WarningLabel Hazard Warning CAUTION
Product dust may be irritating to eyes, skin and respiratory system.Label PrecautionsLabel PrecautionsLabel PrecautionsLabel Precautions Avoid breathing dust. Avoid contact with eyes, skin, and clothing. Use only with adequate
ventilation. Wash thoroughly after handling. Keep container closed.Label First AidLabel First AidLabel First AidLabel First Aid Immediately flush eyes with plenty of water for at least 15 minutes. Flush skin thoroughly with
water. If gas/fume/vapor/dust/mist from the material is inhaled, remove the affected personimmediately to fresh air. Get medical attention if symptoms persist. If ingestion of a large amountdoes occur, call a poison control center immediately.
17171717. . . . Other InformationOther InformationOther InformationOther InformationNFPA ratingsNFPA ratingsNFPA ratingsNFPA ratings Health: 1
Flammability: 0Instability: 0
Material name: MAGNESIUM SULFATE HEPTAHYDRATEMSDS ID: M0234 Version #: 02 Revision date: 08-29-2011
MSDS US COV
5 / 6
DisclaimerDisclaimerDisclaimerDisclaimer THE INFORMATION PRESENTED IN THIS MATERIAL SAFETY DATA SHEET (MSDS/SDS)WAS PREPARED BY TECHNICAL PERSONNEL BASED ON DATA THAT THEY BELIEVE INTHEIR GOOD FAITH JUDGMENT IS ACCURATE. HOWEVER, THE INFORMATION PROVIDEDHEREIN IS PROVIDED “AS IS,” AND AVANTOR PERFORMANCE MATERIALS MAKES ANDGIVES NO REPRESENTATIONS OR WARRANTIES WHATSOEVER, AND EXPRESSLYDISCLAIMS ALL WARRANTIES REGARDING SUCH INFORMATION AND THE PRODUCT TOWHICH IT RELATES, WHETHER EXPRESS, IMPLIED, OR STATUTORY, INCLUDINGWITHOUT LIMITATION, WARRANTIES OF ACCURACY, COMPLETENESS,MERCHANTABILITY, NON-INFRINGEMENT, PERFORMANCE, SAFETY, SUITABILITY,STABILITY, AND FITNESS FOR A PARTICULAR PURPOSE, AND ANY WARRANTIES ARISINGFROM COURSE OF DEALING, COURSE OF PERFORMANCE, OR USAGE OF TRADE. THISMSDS/SDS IS INTENDED ONLY AS A GUIDE TO THE APPROPRIATE PRECAUTIONARYHANDLING OF THE MATERIAL BY A PROPERLY TRAINED PERSON USING THIS PRODUCT,AND IS NOT INTENDED TO BE COMPREHENSIVE AS TO THE MANNER AND CONDITIONSOF USE, HANDLING, STORAGE, OR DISPOSAL OF THE PRODUCT. INDIVIDUALSRECEIVING THIS MSDS/SDS MUST ALWAYS EXERCISE THEIR OWN INDEPENDENTJUDGMENT IN DETERMINING THE APPROPRIATENESS OF SUCH ISSUES. ACCORDINGLY,AVANTOR PERFORMANCE MATERIALS ASSUMES NO LIABILITY WHATSOEVER FOR THEUSE OF OR RELIANCE UPON THIS INFORMATION. NO SUGGESTIONS FOR USE AREINTENDED AS, AND NOTHING HEREIN SHALL BE CONSTRUED AS, A RECOMMENDATIONTO INFRINGE ANY EXISTING PATENTS OR TO VIOLATE ANY FEDERAL, STATE, LOCAL, ORFOREIGN LAWS. AVANTOR PERFORMANCE MATERIALS REMINDS YOU THAT IT IS YOURLEGAL DUTY TO MAKE ALL INFORMATION IN THIS MSDS/SDS AVAILABLE TO YOUREMPLOYEES.
Issue dateIssue dateIssue dateIssue date 08-29-2011
Material name: MAGNESIUM SULFATE HEPTAHYDRATEMSDS ID: M0234 Version #: 02 Revision date: 08-29-2011
MSDS US COV
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SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Revision Date 29.08.2017 Version 1.1
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 12
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 102415
Product name D(+)-Glucose anhydrous for cell culture media
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.
CAS-No. 50-99-7
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Pharmaceutical production
For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * 8th Floor, Godrej One,
Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079
India * Tel: 0091 22 6210 9000
Responsible Department Quality Assurance * Merck Life Science Private Limited *
e-mail: [email protected] *
Tel : +91-2267863131-6
1.4 Emergency telephone
number
Please contact the regional company representation in your country.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102415
Product name D(+)-Glucose anhydrous for cell culture media
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 12
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
This substance is not classified as dangerous according to European Union legislation.
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
2.3 Other hazards
None known.
SECTION 3. Composition/information on ingredients
3.1 Substance
Formula C₆H₁₂O₆ (Hill)
EC-No. 200-075-1
Molar mass 180.16 g/mol
Remarks No disclosure requirement according to Regulation (EC) No.
1907/2006.
3.2 Mixture
Not applicable
SECTION 4. First aid measures
4.1 Description of first aid measures
After inhalation: fresh air.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102415
Product name D(+)-Glucose anhydrous for cell culture media
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 12
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower.
After eye contact: rinse out with plenty of water. Remove contact lenses.
After swallowing: make victim drink water (two glasses at most). Consult doctor if feeling unwell.
4.2 Most important symptoms and effects, both acute and delayed
We have no description of any toxic symptoms.
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SECTION 5. Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Water, Foam, Carbon dioxide (CO2), Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Combustible.
Development of hazardous combustion gases or vapours possible in the event of fire.
Risk of dust explosion.
5.3 Advice for firefighters
Special protective equipment for firefighters
In the event of fire, wear self-contained breathing apparatus.
Further information
Prevent fire extinguishing water from contaminating surface water or the ground water system.
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102415
Product name D(+)-Glucose anhydrous for cell culture media
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 4 of 12
Advice for non-emergency personnel: Avoid inhalation of dusts. Evacuate the danger area,
observe emergency procedures, consult an expert.
Advice for emergency responders:
Protective equipment see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see
sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation
of dusts.
6.4 Reference to other sections
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handling
Observe label precautions.
Hygiene measures
Change contaminated clothing. Wash hands after working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed. Dry.
Recommended storage temperature see product label.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102415
Product name D(+)-Glucose anhydrous for cell culture media
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 5 of 12
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
Contains no substances with occupational exposure limit values.
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Eye/face protection
Safety glasses
Hand protection
full contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: 480 min
splash contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: 480 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 741 Dermatril® L (full contact),
KCL 741 Dermatril® L (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102415
Product name D(+)-Glucose anhydrous for cell culture media
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 6 of 12
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Respiratory protection
required when dusts are generated.
Recommended Filter type: Filter P 1 (acc. to DIN 3181) for solid particles of inert substances
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
Environmental exposure controls
Do not let product enter drains.
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
Form solid
Colour colourless
Odour odourless
Odour Threshold Not applicable
pH No information available.
Melting point ca. 146 °C
Boiling point No information available.
Flash point No information available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102415
Product name D(+)-Glucose anhydrous for cell culture media
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 7 of 12
Evaporation rate No information available.
Flammability (solid, gas) No information available.
Lower explosion limit No information available.
Upper explosion limit No information available.
Vapour pressure No information available.
Relative vapour density No information available.
Density No information available.
Relative density No information available.
Water solubility ca.470 g/l
at 20 °C
Partition coefficient: n-
octanol/water
log Pow: -3.24
(experimental)
(Lit.) Bioaccumulation is not expected.
Auto-ignition temperature No information available.
Decomposition temperature No information available.
Viscosity, dynamic No information available.
Explosive properties Not classified as explosive.
Oxidizing properties none
9.2 Other data
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102415
Product name D(+)-Glucose anhydrous for cell culture media
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 8 of 12
Ignition temperature ca. 500 °C
Bulk density ca.630 kg/m3
SECTION 10. Stability and reactivity
10.1 Reactivity
Risk of dust explosion.
10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.3 Possibility of hazardous reactions
Exothermic reaction with:
halogenates, nitrates, permanganates, Strong oxidizing agents
10.4 Conditions to avoid
no information available
10.5 Incompatible materials
no information available
10.6 Hazardous decomposition products
no information available
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Acute oral toxicity
LD50 Rat: 25,800 mg/kg
(RTECS)
Acute inhalation toxicity
This information is not available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102415
Product name D(+)-Glucose anhydrous for cell culture media
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 9 of 12
Acute dermal toxicity
This information is not available.
Skin irritation
This information is not available.
Eye irritation
This information is not available.
Sensitisation
This information is not available.
Germ cell mutagenicity
This information is not available.
Carcinogenicity
This information is not available.
Reproductive toxicity
This information is not available.
Teratogenicity
This information is not available.
Specific target organ toxicity - single exposure
This information is not available.
Specific target organ toxicity - repeated exposure
This information is not available.
Aspiration hazard
This information is not available.
11.2 Further information
Our own experience has provided no indication of any hazardous potential.
Substance which occurs in the human body under physiological conditions.
Substances which occur in nature
Handle in accordance with good industrial hygiene and safety practice.
SECTION 12. Ecological information
12.1 Toxicity
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102415
Product name D(+)-Glucose anhydrous for cell culture media
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 10 of 12
Toxicity to fish
LC0 fish: 60,000 mg/l
(External MSDS)
12.2 Persistence and degradability
Biodegradability
48 %; 5 d
OECD Test Guideline 301D
Readily biodegradable
12.3 Bioaccumulative potential
Partition coefficient: n-octanol/water
log Pow: -3.24
(experimental)
(Lit.) Bioaccumulation is not expected.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.
12.6 Other adverse effects
Additional ecological information
Discharge into the environment must be avoided.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102415
Product name D(+)-Glucose anhydrous for cell culture media
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 11 of 12
SECTION 13. Disposal considerations
Waste treatment methods
Waste material must be disposed of in accordance with the national and local regulations. Leave
chemicals in original containers. No mixing with other waste. Handle uncleaned containers like
the product itself.
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Sea transport (IMDG)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National legislation
Storage class 10 - 13
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102415
Product name D(+)-Glucose anhydrous for cell culture media
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 12 of 12
15.2 Chemical safety assessment
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Training advice
Provide adequate information, instruction and training for operators.
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006
Date of issue: 04.11.2015 Version 1.0
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 8
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 420291
Product name IPTG, Animal-Free, High Purity
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.
CAS-No. 367-93-1
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Biochemical research/analysis
For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * Shiv Sagar Estate 'A', Dr. Annie
Besant Road, Worli Mumbai - 400 018 India * Tel:0091 22 66609000
Responsible Department Quality Assurance * Merck Specialities Private Limited *
e-mail: [email protected] *
Tel : +91-2267863131-6
1.4 Emergency telephone
number
Please contact the regional company representation in your country.
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
This substance is not classified as dangerous according to European Union legislation.
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
2.3 Other hazards
None known.
SECTION 3. Composition/information on ingredients
3.1 Substance
Formula C₉H₁₈O₅S (Hill)
EC-No. 206-703-0
Molar mass 238.3 g/mol
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 420291
Product name IPTG, Animal-Free, High Purity
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 8
Remarks No disclosure requirement according to Regulation (EC) No.
1907/2006
3.2 Mixture
Not applicable
SECTION 4. First aid measures
4.1 Description of first aid measures
After inhalation: fresh air.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower.
After eye contact: rinse out with plenty of water.
After swallowing: make victim drink water (two glasses at most). Consult doctor if feeling unwell.
4.2 Most important symptoms and effects, both acute and delayed
We have no description of any toxic symptoms.
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SECTION 5. Firefighting measures
5.1 Extinguishing media
Suitable extinguishing mediaWater, Carbon dioxide (CO2), Foam, Dry powder
Unsuitable extinguishing mediaFor this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Combustible.
Development of hazardous combustion gases or vapours possible in the event of fire.
Fire may cause evolution of:
Sulphur oxides
5.3 Advice for firefighters
Special protective equipment for firefightersIn the event of fire, wear self-contained breathing apparatus.
Further informationSuppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing
water from contaminating surface water or the ground water system.
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid inhalation of dusts. Evacuate the danger area,
observe emergency procedures, consult an expert.
Advice for emergency responders: Protective equipment see section 8.
6.2 Environmental precautions
Do not empty into drains.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 420291
Product name IPTG, Animal-Free, High Purity
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 8
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills.
Observe possible material restrictions (see sections 7 and 10).
Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.
6.4 Reference to other sections
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handlingObserve label precautions.
Hygiene measuresChange contaminated clothing. Wash hands after working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditionsTightly closed. Dry. Protected from light.
Recommended storage temperature see product label.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
Contains no substances with occupational exposure limit values.
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Eye/face protectionSafety glasses
Hand protection
full contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
splash contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 420291
Product name IPTG, Animal-Free, High Purity
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 4 of 8
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 741 Dermatril® L (full contact),
KCL 741 Dermatril® L (splash contact).
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Respiratory protectionrequired when dusts are generated.
Recommended Filter type: Filter P 1 (acc. to DIN 3181) for solid particles of inert substances
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
Environmental exposure controls
Do not empty into drains.
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
Form solid
Colour white
Odour odourless
Odour Threshold Not applicable
pH No information available.
Melting point 109 - 111 °C
Boiling point No information available.
Flash point > 110 °C
Evaporation rate No information available.
Flammability (solid, gas) No information available.
Lower explosion limit No information available.
Upper explosion limit No information available.
Vapour pressure No information available.
Relative vapour density No information available.
Density No information available.
Relative density No information available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 420291
Product name IPTG, Animal-Free, High Purity
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 5 of 8
Water solubility 10 g/l
at 20 °C
Partition coefficient: n-
octanol/water
log Pow: -1.26
(experimental)
(Lit.) Bioaccumulation is not expected.
Auto-ignition temperature No information available.
Decomposition temperature No information available.
Viscosity, dynamic No information available.
Explosive properties Not classified as explosive.
Oxidizing properties none
9.2 Other data
Bulk density ca.500 kg/m3
SECTION 10. Stability and reactivity
10.1 Reactivity
The following applies in general to flammable organic substances and mixtures: in
correspondingly fine distribution, when whirled up a dust explosion potential may generally be
assumed.
10.2 Chemical stability
Sensitivity to light
10.3 Possibility of hazardous reactions
Violent reactions possible with:
Strong oxidizing agents
10.4 Conditions to avoid
no information available
10.5 Incompatible materials
no information available
10.6 Hazardous decomposition products
in the event of fire: See section 5.
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Acute oral toxicityThis information is not available.
Acute inhalation toxicityThis information is not available.
Acute dermal toxicityThis information is not available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 420291
Product name IPTG, Animal-Free, High Purity
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 6 of 8
Skin irritationThis information is not available.
Eye irritationThis information is not available.
Sensitisation
Sensitisation possible in predisposed persons.
Germ cell mutagenicityThis information is not available.
CarcinogenicityThis information is not available.
Reproductive toxicityThis information is not available.
TeratogenicityThis information is not available.
Specific target organ toxicity - single exposureThis information is not available.
Specific target organ toxicity - repeated exposureThis information is not available.
Aspiration hazardThis information is not available.
11.2 Further information
Hazardous properties cannot be excluded but are unlikely when the product is handled
appropriately.
Handle in accordance with good industrial hygiene and safety practice.
SECTION 12. Ecological information
12.1 Toxicity
No information available.
12.2 Persistence and degradability
No information available.
12.3 Bioaccumulative potential
Partition coefficient: n-octanol/waterlog Pow: -1.26
(experimental)
(Lit.) Bioaccumulation is not expected.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.
12.6 Other adverse effects
Discharge into the environment must be avoided.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 420291
Product name IPTG, Animal-Free, High Purity
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 7 of 8
SECTION 13. Disposal considerations
Waste treatment methodsWaste material must be disposed of in accordance with the national and local regulations. Leave
chemicals in original containers. No mixing with other waste. Handle uncleaned containers like
the product itself.
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Sea transport (IMDG)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National legislation
Storage class 10 - 13
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Training advice
Provide adequate information, instruction and training for operators.
Labelling (67/548/EEC or 1999/45/EC)
The product does not need to be labelled in accordance with EC directives or respective national
laws.
Key or legend to abbreviations and acronyms used in the safety data sheet
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 420291
Product name IPTG, Animal-Free, High Purity
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 8 of 8
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
Sigma - A6426 Page 1 of 6
SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006 Version 5.0 Revision Date 07.01.2013
Print Date 18.03.2013
1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
1.1 Product identifiers Product name : Antifoam 204
Product Number : A6426 Brand : Sigma
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances
1.3 Details of the supplier of the safety data sheet
Company : Sigma-Aldrich Company Ltd. The Old Brickyard NEW ROAD, GILLINGHAM Dorset SP8 4XT UNITED KINGDOM
Telephone : +44 (0)1747 833000 Fax : +44 (0)1747 833313 E-mail address : [email protected]
1.4 Emergency telephone number
Emergency Phone # : +44 (0)1747 833100
2. HAZARDS IDENTIFICATION
2.1 Classification of the substance or mixture Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008. This substance is not classified as dangerous according to Directive 67/548/EEC.
2.2 Label elements
The product does not need to be labelled in accordance with EC directives or respective national laws.
2.3 Other hazards - none
3. COMPOSITION/INFORMATION ON INGREDIENTS
3.1 Substances
4. FIRST AID MEASURES
4.1 Description of first aid measures
If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration.
In case of skin contact Wash off with soap and plenty of water.
In case of eye contact Flush eyes with water as a precaution.
If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water.
Sigma - A6426 Page 2 of 6
4.2 Most important symptoms and effects, both acute and delayed To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
4.3 Indication of any immediate medical attention and special treatment needed no data available
5. FIREFIGHTING MEASURES
5.1 Extinguishing media
Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture Nature of decomposition products not known.
5.3 Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary.
5.4 Further information no data available
6. ACCIDENTAL RELEASE MEASURES
6.1 Personal precautions, protective equipment and emergency procedures Avoid breathing vapors, mist or gas.
6.2 Environmental precautions Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up Keep in suitable, closed containers for disposal.
6.4 Reference to other sections For disposal see section 13.
7. HANDLING AND STORAGE
7.1 Precautions for safe handling no data available
7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
7.3 Specific end use(s) no data available
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1 Control parameters
Components with workplace control parameters Contains no substances with occupational exposure limit values.
8.2 Exposure controls
Appropriate engineering controls General industrial hygiene practice.
Personal protective equipment
Eye/face protection Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
Sigma - A6426 Page 3 of 6
contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Impervious clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection Respiratory protection not required. For nuisance exposures use type OV/AG (US) or type ABEK (EU EN 14387) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
9. PHYSICAL AND CHEMICAL PROPERTIES
9.1 Information on basic physical and chemical properties
a) Appearance Form: viscous liquid Colour: colourless
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing point
no data available
f) Initial boiling point and boiling range
no data available
g) Flash point no data available
h) Evaporation rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower flammability or explosive limits
no data available
k) Vapour pressure no data available
l) Vapour density no data available
m) Relative density 1.01 g/cm3 at 25 °C
n) Water solubility no data available
o) Partition coefficient: n-octanol/water
no data available
p) Auto-ignition temperature
no data available
q) Decomposition temperature
no data available
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
9.2 Other safety information no data available
10. STABILITY AND REACTIVITY
10.1 Reactivity no data available
Sigma - A6426 Page 4 of 6
10.2 Chemical stability no data available
10.3 Possibility of hazardous reactions no data available
10.4 Conditions to avoid no data available
10.5 Incompatible materials Strong oxidizing agents
10.6 Hazardous decomposition products Other decomposition products - no data available
11. TOXICOLOGICAL INFORMATION
11.1 Information on toxicological effects
Acute toxicity no data available
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure no data available
Specific target organ toxicity - repeated exposure no data available
Aspiration hazard no data available
Potential health effects
Inhalation May be harmful if inhaled. May cause respiratory tract irritation. Ingestion May be harmful if swallowed. Skin May be harmful if absorbed through skin. May cause skin irritation. Eyes May cause eye irritation.
Signs and Symptoms of Exposure To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Additional Information RTECS: Not available
12. ECOLOGICAL INFORMATION
12.1 Toxicity no data available
Sigma - A6426 Page 5 of 6
12.2 Persistence and degradability no data available
12.3 Bioaccumulative potential no data available
12.4 Mobility in soil no data available
12.5 Results of PBT and vPvB assessment no data available
12.6 Other adverse effects no data available
13. DISPOSAL CONSIDERATIONS
13.1 Waste treatment methods
Product Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging Dispose of as unused product.
14. TRANSPORT INFORMATION
14.1 UN number ADR/RID: - IMDG: - IATA: -
14.2 UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods
14.3 Transport hazard class(es) ADR/RID: - IMDG: - IATA: -
14.4 Packaging group ADR/RID: - IMDG: - IATA: -
14.5 Environmental hazards ADR/RID: no IMDG Marine Pollutant: no IATA: no
14.6 Special precautions for user no data available
15. REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture no data available
15.2 Chemical Safety Assessment no data available
16. OTHER INFORMATION
Further information Copyright 2013 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.
Sigma - A6426 Page 6 of 6
Sigma - 60615 Page 1 of 7
SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 30.03.2016
Print Date 25.05.2018 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA
SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1 Product identifiers Product name : Kanamycin sulfate
Product Number : 60615 Brand : Sigma REACH No. : A registration number is not available for this substance as the substance
or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.
CAS-No. : 70560-51-9
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances
1.3 Details of the supplier of the safety data sheet
Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA
1.4 Emergency telephone number
Emergency Phone # : +91 98802 05043
SECTION 2: Hazards identification
2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 Reproductive toxicity (Category 1B), H360
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008 Pictogram
Signal word Danger Hazard statement(s) H360 May damage fertility or the unborn child. Precautionary statement(s) P201 Obtain special instructions before use. P308 + P313 IF exposed or concerned: Get medical advice/ attention. Supplemental Hazard Statements
none
Sigma - 60615 Page 2 of 7
Restricted to professional users.
2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
SECTION 3: Composition/information on ingredients
3.1 Substances CAS-No. : 70560-51-9 Hazardous ingredients according to Regulation (EC) No 1272/2008
Component Classification Concentration
Kanamycin sulfate, mixture of the components A, B and C
CAS-No.
70560-51-9
Repr. 1B; H360 <= 100 %
For the full text of the H-Statements mentioned in this Section, see Section 16.
SECTION 4: First aid measures
4.1 Description of first aid measures
General advice Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact Wash off with soap and plenty of water. Consult a physician.
In case of eye contact Flush eyes with water as a precaution.
If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed No data available
SECTION 5: Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture Nature of decomposition products not known.
5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information No data available
Sigma - 60615 Page 3 of 7
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
6.4 Reference to other sections For disposal see section 13.
SECTION 7: Handling and storage
7.1 Precautions for safe handling Avoid formation of dust and aerosols.Avoid exposure - obtain special instructions before use. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
8.2 Exposure controls
Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
Personal protective equipment
Eye/face protection Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm
Sigma - 60615 Page 4 of 7
Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (EN 143) respirator cartridges as a backup to engineering controls. If th full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
SECTION 9: Physical and chemical properties
9.1 Information on basic physical and chemical properties
a) Appearance Form: powder Colour: white
b) Odour No data available
c) Odour Threshold No data available
d) pH No data available
e) Melting point/freezing point
No data available
f) Initial boiling point and boiling range
No data available
g) Flash point No data available
h) Evaporation rate No data available
i) Flammability (solid, gas) No data available
j) Upper/lower flammability or explosive limits
No data available
k) Vapour pressure No data available
l) Vapour density No data available
m) Relative density No data available
n) Water solubility No data available
o) Partition coefficient: n-octanol/water
No data available
p) Auto-ignition temperature
No data available
q) Decomposition temperature
No data available
r) Viscosity No data available
s) Explosive properties No data available
Sigma - 60615 Page 5 of 7
t) Oxidizing properties No data available
9.2 Other safety information No data available
SECTION 10: Stability and reactivity
10.1 Reactivity No data available
10.2 Chemical stability Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions No data available
10.4 Conditions to avoid No data available
10.5 Incompatible materials Strong oxidizing agents
10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Nature of decomposition products not known. Other decomposition products - No data available In the event of fire: see section 5
SECTION 11: Toxicological information
11.1 Information on toxicological effects
Acute toxicity No data availableKanamycin sulfate, mixture of the components A, B and C
Skin corrosion/irritation No data available(Kanamycin sulfate, mixture of the components A, B and C)
Serious eye damage/eye irritation No data available(Kanamycin sulfate, mixture of the components A, B and C)
Respiratory or skin sensitisation No data available(Kanamycin sulfate, mixture of the components A, B and C)
Germ cell mutagenicity No data available(Kanamycin sulfate, mixture of the components A, B and C)
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
Presumed human reproductive toxicant(Kanamycin sulfate, mixture of the components A, B and C)
Specific target organ toxicity - single exposure No data available(Kanamycin sulfate, mixture of the components A, B and C)
Specific target organ toxicity - repeated exposure No data available
Aspiration hazard No data available(Kanamycin sulfate, mixture of the components A, B and C)
Additional Information RTECS: Not available
Sigma - 60615 Page 6 of 7
Aminoglycosides are associated with significant nephrotoxicity and/or ototoxicity.(Kanamycin sulfate, mixture of the components A, B and C)
SECTION 12: Ecological information
12.1 Toxicity No data available
12.2 Persistence and degradability No data available
12.3 Bioaccumulative potential No data available
12.4 Mobility in soil No data available(Kanamycin sulfate, mixture of the components A, B and C)
12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
12.6 Other adverse effects No data available
SECTION 13: Disposal considerations
13.1 Waste treatment methods
Product Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chem scrubber.
Contaminated packaging Dispose of as unused product.
SECTION 14: Transport information
14.1 UN number ADR/RID: - IMDG: - IATA: -
14.2 UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods
14.3 Transport hazard class(es) ADR/RID: - IMDG: - IATA: -
14.4 Packaging group ADR/RID: - IMDG: - IATA: -
14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user No data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out
Sigma - 60615 Page 7 of 7
SECTION 16: Other information
Full text of H-Statements referred to under sections 2 and 3.
H360 May damage fertility or the unborn child.
Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.
Page 1/7
Safety data sheetaccording to 1907/2006/EC, Article 31
Date Prepared: 24.03.2014 Revision: 08.01.2013
38.0.21
1 Identification of the substance/mixture and of the company/undertaking
· Product identifier· Trade name: Bacto Tryptone Peptone· Article number: 211705· Relevant identified uses of the substance or mixture and uses advised against· Sector of Use
SU3 Industrial uses: Uses of substances as such or in preparations at industrial sitesSU22 Professional uses: Public domain (administration, education, entertainment, services,craftsmen)SU20 Health servicesSU24 Scientific research and development
· Application of the substance / the mixtureIn-vitro DiagnosticsPreparation
· Details of the supplier of the safety data sheet· Manufacturer/Supplier:
BD Diagnostic Systems EuropeRegulatory Compliance DepartmentBecton Dickinson France11, rue Aristide Bergès38800 Le Pont de ClaixFranceTelephone: 33 (0) 476 68 36 36Email: [email protected]
· Further information obtainable from: Technical Service Representative· Emergency telephone number: Tel: 33 (0) 476 68 36 36
2 Hazards identification
· Classification of the substance or mixture· Classification according to Regulation (EC) No 1272/2008
The product is not classified according to the CLP regulation.
· Classification according to Directive 67/548/EEC or Directive 1999/45/ECThis product contains no hazardous constituents, or the concentration of all chemicalconstituents are below the regulatory threshold limits described by the Occupational Safetyand Health Administration Hazard Communication Standard or European Directive 67/548/EEC and 1999/45/EC.
· Information concerning particular hazards for human and environment:Not applicableThe product does not have to be labelled due to the calculation procedure of the "GeneralClassification guideline for preparations of the EU" in the latest valid version.
· Classification system:The classification is according to the latest editions of the EU-lists, and extended by companyand literature data.
(Contd. on page 2) EU
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Safety data sheetaccording to 1907/2006/EC, Article 31
Date Prepared: 24.03.2014 Revision: 08.01.2013
Trade name: Bacto Tryptone Peptone
(Contd. of page 1)
38.0.21
· Label elements
· Labelling according to EU guidelines:Observe the general safety regulations when handling chemicalsThe product is not subject to identification regulations under EU Directives and the Ordinanceon Hazardous Materials (German GefStoffV).
· Other hazards· Results of PBT and vPvB assessment· PBT: Not applicable.· vPvB: Not applicable.
3 Composition/information on ingredients
· Chemical characterization: Mixtures· Description: Mixture consisting of the following components.
· Dangerous components: Void· Additional information For the wording of the listed risk phrases refer to section 15.
4 First aid measures
· Description of first aid measures· General information No special measures required.· After inhalation Seek medical treatment in case of complaints.· After skin contact Immediately wash with water and soap and rinse thoroughly.· After eye contact
Rinse opened eye for several minutes under running water. If symptoms persist, consult adoctor.
· After swallowing If symptoms persist consult doctor.· Information for doctor· Most important symptoms and effects, both acute and delayed
No further relevant information available.· Indication of any immediate medical attention and special treatment needed
No further relevant information available.
5 Firefighting measures
· Extinguishing media· Suitable extinguishing agents
CO2, powder or water spray. Fight larger fires with water spray or alcohol resistant foam.· Special hazards arising from the substance or mixture
No further relevant information available.(Contd. on page 3)
EU
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Date Prepared: 24.03.2014 Revision: 08.01.2013
Trade name: Bacto Tryptone Peptone
(Contd. of page 2)
38.0.21
· Advice for firefighters· Protective equipment: No special measures required.
6 Accidental release measures
· Personal precautions, protective equipment and emergency procedures Not required.· Environmental precautions: Wipe up with damp sponge or mop.· Methods and material for containment and cleaning up: No special measures required.· Reference to other sections No dangerous substances are released.
7 Handling and storage
· Handling· Precautions for safe handling No special measures required.· Information about fire - and explosion protection: No special measures required.
· Conditions for safe storage, including any incompatibilities· Storage· Requirements to be met by storerooms and receptacles: 2 - 25℃· Information about storage in one common storage facility:
Store away from oxidizing agents.· Further information about storage conditions:
Store in cool, dry conditions in well sealed receptacles.· Specific end use(s) No further relevant information available.
8 Exposure controls/personal protection
· Additional information about design of technical facilities: No further data; see item 7.
· Control parameters· Ingredients with limit values that require monitoring at the workplace:
The product does not contain any relevant quantities of materials with critical values thathave to be monitored at the workplace.
· Additional information: The lists valid during the making were used as basis.
· Exposure controls· Personal protective equipment· General protective and hygienic measures
The usual precautionary measures are to be adhered to when handling chemicals.· Respiratory protection: Not required.· Protection of hands:
Protective gloves.
(Contd. on page 4) EU
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Date Prepared: 24.03.2014 Revision: 08.01.2013
Trade name: Bacto Tryptone Peptone
(Contd. of page 3)
38.0.21
· Eye protection: Safety glasses· Body protection: Protective work clothing.
9 Physical and chemical properties
· Information on basic physical and chemical properties· General Information· Appearance:
Form: Solid.Powder
Colour: Beige· Odour: Characteristic
· Change in conditionMelting point/Melting range: Not determinedBoiling point/Boiling range: Not determined
· Flash point: Not applicable
· Flammability (solid, gaseous) Product is not flammable.
· Danger of explosion: Product does not present an explosion hazard.
· Density: Not determined
· Solubility in / Miscibility withWater: Soluble
· Solvent content:Organic solvents: 0,0 %
Solids content: 100,0 %· Other information No further relevant information available.
10 Stability and reactivity
· Reactivity· Chemical stability· Thermal decomposition / conditions to be avoided:
No decomposition if used according to specifications.· Possibility of hazardous reactions No dangerous reactions known· Conditions to avoid No further relevant information available.· Incompatible materials: No further relevant information available.· Hazardous decomposition products: No dangerous decomposition products known
EU
(Contd. on page 5)
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Date Prepared: 24.03.2014 Revision: 08.01.2013
Trade name: Bacto Tryptone Peptone
(Contd. of page 4)
38.0.21
11 Toxicological information
· Information on toxicological effects· Acute toxicity:· Primary irritant effect:· on the skin: No irritant effect.· on the eye: No irritating effect.· Sensitization: No sensitizing effects known.· Additional toxicological information:
The product is not subject to classification according to the calculation method of the GeneralEU Classification Guidelines for Preparations as issued in the latest version.When used and handled according to specifications, the product does not have any harmfuleffects to our experience and the information provided to us.
12 Ecological information
· Toxicity· Aquatic toxicity: No further relevant information available.· Persistence and degradability No further relevant information available.· Behaviour in environmental systems:· Bioaccumulative potential No further relevant information available.· Mobility in soil No further relevant information available.· Ecotoxical effects:· Other information:
The ecological effects have not ben thoroughly investigated, but currently none have beenidentified.
· Additional ecological information:· General notes: Generally not hazardous for water.· Results of PBT and vPvB assessment· PBT: Not applicable.· vPvB: Not applicable.· Other adverse effects No further relevant information available.
13 Disposal considerations
· Waste treatment methods· Recommendation
Must be specially treated adhering to official regulations.Smaller quantities can be disposed of with household waste.
· Uncleaned packaging:· Recommendation: Disposal must be made according to official regulations.
(Contd. on page 6) EU
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Trade name: Bacto Tryptone Peptone
(Contd. of page 5)
38.0.21
· Recommended cleansing agents: Water, if necessary together with cleansing agents.
14 Transport information
· UN-Number· ADR, ADN, IMDG, IATA Void
· UN proper shipping name· ADR, ADN, IMDG, IATA Void
· Transport hazard class(es)
· ADR, ADN, IMDG, IATA· Class Void
· Packing group· ADR, IMDG, IATA Void
· Environmental hazards:· Marine pollutant: No
· Special precautions for user Not applicable.
· Transport in bulk according to Annex II ofMARPOL73/78 and the IBC Code Not applicable.
· UN "Model Regulation": -
15 Regulatory information
· Safety, health and environmental regulations/legislation specific for the substance ormixture
· Labelling according to EU guidelines:Observe the general safety regulations when handling chemicalsThe product is not subject to identification regulations under EU Directives and the Ordinanceon Hazardous Materials (German GefStoffV).
· Chemical safety assessment: A Chemical Safety Assessment has not been carried out.
16 Other informationDisclaimer:To the best of our knowledge, the information contained herein is accurate. However, neitherBD or any of its subsidiaries assums any liabilities whatsoever for the accuracy orcompleteness of the information contained herein. Final determination of suitability of anymaterial is the sole responsibility of the user. All materials may present unknown hazards andshould be used with caution. Although certain hazards described herein, we cannotguarantee that these are the only hazards that exist.
(Contd. on page 7) EU
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Trade name: Bacto Tryptone Peptone
(Contd. of page 6)
38.0.21
· Department issuing MSDS:Environmental, Health & SafetyCreated by Michael J. Spinazzola
· Contact: Technical Service Representative· Abbreviations and acronyms:
ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreementconcerning the International Carriage of Dangerous Goods by Road)IMDG: International Maritime Code for Dangerous GoodsIATA: International Air Transport AssociationGHS: Globally Harmonized System of Classification and Labelling of ChemicalsEINECS: European Inventory of Existing Commercial Chemical SubstancesELINCS: European List of Notified Chemical SubstancesCAS: Chemical Abstracts Service (division of the American Chemical Society)
EU
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1 Identification
· Product Identifier· Product Name: Bacto Yeast Extract, Technical· Catalog Number: 288620· CAS Number:
8013-01-2· Relevant identified uses of the substance or mixture and uses advised against
No further relevant information available.· Application of the substance / the mixture In-vitro Diagnostics
· Details of the supplier of the safety data sheet· Manufacturer/Supplier:
BD Diagnostic Systems7 Loveton CircleSparks, MD 21152Telephone: (410) 771 - 0100 or (800) 638 – 8663Email Address: [email protected]
· Information Department: Technical Service· Emergency telephone number:
In case of a chemical emergency, spill, fire, exposure, or accident, contact BD DiagnosticSystems (410) 771-0100 or (800)-638-8663, or ChemTrec at (800) 424-9300.
2 Hazard(s) identification
· Classification of the substance or mixtureThe substance is not classified according to the Globally Harmonized System (GHS).
· Classification according to Directive 67/548/EEC or Directive 1999/45/ECThis product contains no hazardous constituents, or the concentration of all chemicalconstituents are below the regulatory threshold limits described by Occupational SafetyHealth Administration Hazard Communication Standard 29 CFR 1910.1200, the Canada'sWorkplace Hazardous Materials Information System (WHMIS) and the European Directive67/548/EEC and 1999/45/EC.
· Label elements· GHS label elements Void· Hazard pictograms Void· Signal word Void· Hazard statements Void· NFPA ratings (scale 0-4)
00
0
Health = 0Flammability = 0Reactivity = 0
· HMIS ratings (scale 0-4)
HEALTH
FIRE
REACTIVITY
0
0
0
Health = 0Flammability = 0Reactivity = 0
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· Other hazards· Results of PBT and vPvB assessment· PBT: Not applicable.· vPvB: Not applicable.
3 Composition/information on ingredients
· Chemical characterization: Substances· CAS No. Description:
8013-01-2 yeast extract
4 First-aid measures
· Description of first aid measures· General information No special measures required.· After inhalation Seek medical treatment in case of complaints.· After skin contact Immediately wash with water and soap and rinse thoroughly.· After eye contact
Rinse opened eye for several minutes under running water. If symptoms persist, consult adoctor.
· After swallowing If symptoms persist consult doctor.· Information for doctor Show this product label or this MSDS.· Most important symptoms and effects, both acute and delayed
No further relevant information available.· Indication of any immediate medical attention and special treatment needed
No further relevant information available.
5 Fire-fighting measures
· Extinguishing media· Suitable extinguishing agents
CO2, ABC multipurpose dry chemical or water spray. Fight larger fires with water spray oralcohol resistant foam.
· Special hazards arising from the substance or mixtureNo further relevant information available.
· Advice for firefighters· Protective equipment: No special measures required.
6 Accidental release measures
· Personal precautions, protective equipment and emergency procedures Not required.· Environmental precautions: Wipe up with damp sponge or mop.· Methods and material for containment and cleaning up: No special measures required.
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· Reference to other sectionsSee Section 7 for information on safe handling.See Section 8 for information on personal protection equipment.See Section 13 for disposal information.
7 Handling and storage
· Handling· Precautions for safe handling Ensure good ventilation/exhaustion at the workplace.· Information about protection against explosions and fires:
No special measures required.
· Conditions for safe storage, including any incompatibilities· Storage· Requirements to be met by storerooms and receptacles: < 30 ℃· Information about storage in one common storage facility:
Store away from oxidizing agents.· Further information about storage conditions:
Store in cool, dry conditions in well sealed containers.· Specific end use(s) No further relevant information available.
8 Exposure controls/personal protection
· Additional information about design of technical systems:No further data; see Section 7.
· Control parameters· Components with limit values that require monitoring at the workplace: Not required.· Additional information: The lists that were valid during the creation were used as basis.
· Exposure controls· Personal Protective Equipment· General protective and hygienic measures
Wash hands before breaks and at the end of work.· Breathing equipment:
In case of brief exposure, use a chemical fume hood or a NIOSH/MSHA-approved respirator.· Protection of hands:
Chemical resistant gloves (i.e. nitrile, or equivalent).
· Eye protection: Safety glasses· Body protection: Protective work clothing (lab coat).
US
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9 Physical and chemical properties
· Information on basic physical and chemical properties· General Information· Appearance:
Form: Solid.Powder
Color: Beige· Odor: Characteristic
· Change in conditionMelting point/Melting range: Not determinedBoiling point/Boiling range: Not determined
· Flash point: Not applicable
· Flammability (solid, gaseous) Product is not flammable.
· Danger of explosion: Product does not present an explosion hazard.
· Density: Not determined
· Solubility in / Miscibility withWater: Insoluble
· Other information No further relevant information available.
10 Stability and reactivity
· Reactivity· Chemical stability· Thermal decomposition / conditions to be avoided:
No decomposition if used according to specifications.· Possibility of hazardous reactions No dangerous reactions known· Conditions to avoid No further relevant information available.· Incompatible materials: Incompatible material: strong oxidizers.· Hazardous decomposition products: No dangerous decomposition products known.
11 Toxicological information
· Information on toxicological effects· Acute toxicity:· Primary irritant effect:· on the skin: No irritating effect.· on the eye: No irritating effect.· Sensitization: No sensitizing effects known.
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· Additional toxicological information:The product is not subject to OSHA classification according to internally approved calculationmethods for preparations.When used and handled according to specifications, the product does not have any harmfuleffects according to our experience and the information provided to us.The substance is not subject to classification.
· Carcinogenic categories· IARC (International Agency for Research on Cancer)
Substance is not listed.
· NTP (National Toxicology Program)Substance is not listed.
12 Ecological information
· Toxicity· Aquatic toxicity: No further relevant information available.· Persistence and degradability No further relevant information available.· Behavior in environmental systems:· Bioaccumulative potential No further relevant information available.· Mobility in soil No further relevant information available.· Ecotoxical effects:· Other information:
The ecological effects have not been thoroughly investigated, but currently none have beenidentified.
· Additional ecological information:· General notes: Generally not hazardous for water.· Results of PBT and vPvB assessment· PBT: Not applicable.· vPvB: Not applicable.· Other adverse effects No further relevant information available.
13 Disposal considerations
· Waste treatment methods· Recommendation
Smaller quantities can be disposed of with solid waste.Dispose of material in accordance with federal (40 CFR 261.3), state and local requirements.This product is not considered a RCRA hazardous waste.
· Uncleaned packagings:· Recommendation: Disposal must be made according to state and federal regulations.
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· Recommended cleansing agent: Water, if necessary with cleansing agents.
14 Transport information
· UN-Number
· DOT, ADR, ADN, IMDG, IATA Void
· UN proper shipping name
· DOT, ADR, ADN, IMDG, IATA Void
· Transport hazard class(es)
· DOT, ADR, ADN, IMDG, IATA
· Class Void
· Packing group
· DOT, ADR, IMDG, IATA Void
· Environmental hazards:· Marine pollutant: No
· Special precautions for user Not applicable.
· Transport in bulk according to Annex II ofMARPOL73/78 and the IBC Code Not applicable.
· Transport/Additional information: If a "void" appears in the Hazard Class sectionfor the type of transportation, this indicates theproduct is not regulated for transportation.
· UN "Model Regulation": -
15 Regulatory information
· Safety, health and environmental regulations/legislation specific for the substance ormixture
· SARA Section 355 (extremely hazardous substances)Substance is not listed.
· SARA Section 313 (specific toxic chemical listings)Substance is not listed.
· TSCA (Toxic Substances Control Act)Substance is listed.
· California Proposition 65 - Chemicals known to cause cancerSubstance is not listed.
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· California Proposition 65 - Chemicals known to cause reproductive toxicity forfemales:Substance is not listed.
· California Proposition 65 - Chemicals known to cause reproductive toxicity for males:Substance is not listed.
· California Proposition 65 - Chemicals known to cause developmental toxicity:Substance is not listed.
· Carcinogenic categories· TLV (Threshold Limit Value established by ACGIH)
Substance is not listed.· GHS label elements Void· Hazard pictograms Void· Signal word Void· Hazard statements Void
· National regulations
· Water hazard class: Generally not hazardous for water.· Chemical safety assessment: A Chemical Safety Assessment has not been carried out.
16 Other informationTo the best of our knowledge, the information contained herein is accurate. However, neitherBecton, Dickinson and Company or any of its subsidiaries assumes any liabilities whatsoeverfor the accuracy or completeness of the information contained herein. Final determination ofsuitability of any material is the sole responsibility of the user. All materials may presentunknown hazards and should be used with caution. Although certain hazards are describedherein, we can not guarantee that these are the only hazards that exist.
· Department issuing MSDS:Environmental, Health & SafetyCreated by Michael J. Spinazzola
· Contact: Technical Service Representative· Date of preparation / last revision 03/25/2014 / -· Abbreviations and acronyms:
RID: Règlement international concernant le transport des marchandises dangereuses par chemin de fer(Regulations Concerning the International Transport of Dangerous Goods by Rail)IATA-DGR: Dangerous Goods Regulations by the "International Air Transport Association" (IATA)ICAO: International Civil Aviation OrganizationICAO-TI: Technical Instructions by the "International Civil Aviation Organization" (ICAO)ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreementconcerning the International Carriage of Dangerous Goods by Road)IMDG: International Maritime Code for Dangerous GoodsDOT: US Department of TransportationIATA: International Air Transport AssociationACGIH: American Conference of Governmental Industrial HygienistsCAS: Chemical Abstracts Service (division of the American Chemical Society)NFPA: National Fire Protection Association (USA)HMIS: Hazardous Materials Identification System (USA)
US
MATERIAL SAFETY DATA SHEETMATERIAL SAFETY DATA SHEETMATERIAL SAFETY DATA SHEETMATERIAL SAFETY DATA SHEET
1111. . . . Product and Company IdentificationProduct and Company IdentificationProduct and Company IdentificationProduct and Company IdentificationMaterial nameMaterial nameMaterial nameMaterial name CITRIC ACID MONOHYDRATECITRIC ACID MONOHYDRATECITRIC ACID MONOHYDRATECITRIC ACID MONOHYDRATEVersion #Version #Version #Version # 02Revision dateRevision dateRevision dateRevision date 06-17-2011CAS #CAS #CAS #CAS # 5949-29-1Product CodesProduct CodesProduct CodesProduct Codes J.T.Baker: 0110, 0115, 0116, 0118, 0119, 0120J.T.Baker: 0110, 0115, 0116, 0118, 0119, 0120J.T.Baker: 0110, 0115, 0116, 0118, 0119, 0120J.T.Baker: 0110, 0115, 0116, 0118, 0119, 0120
Macron: 0616, 0627, 11213, 7788Macron: 0616, 0627, 11213, 7788Macron: 0616, 0627, 11213, 7788Macron: 0616, 0627, 11213, 7788Synonym(s)Synonym(s)Synonym(s)Synonym(s) 1,2,3-PROPANETRICARBOXYLIC ACID, 2-HYDROXY-, HYDRATE (1:1)
Customer ServiceCustomer ServiceCustomer ServiceCustomer Service 800-582-253724 Hour Emergency24 Hour Emergency24 Hour Emergency24 Hour Emergency 908-859-2151ChemtrecChemtrecChemtrecChemtrec 800-424-9300
ManufacturerManufacturerManufacturerManufacturerAddressAddressAddressAddress
Avantor Performance Materials, Inc.222 Red School LanePhillipsburg, NJ 08865US
2222. . . . Hazards IdentificationHazards IdentificationHazards IdentificationHazards IdentificationEmergency overviewEmergency overviewEmergency overviewEmergency overview DANGER
Contact will irritate or burn eyes. Irritating to respiratory system and skin.OSHA regulatory statusOSHA regulatory statusOSHA regulatory statusOSHA regulatory status This product is considered hazardous under 29 CFR 1910.1200 (Hazard Communication).
Potential health effectsPotential health effectsPotential health effectsPotential health effectsRoutes of exposureRoutes of exposureRoutes of exposureRoutes of exposure Inhalation. Skin contact. Eye contact. Ingestion.EyesEyesEyesEyes Severely irritating, and may seriously damage eye tissue.SkinSkinSkinSkin Causes skin irritation.InhalationInhalationInhalationInhalation Inhalation of dusts may cause respiratory irritation.IngestionIngestionIngestionIngestion Expected to be a low ingestion hazard. May cause irritation of the gastrointestinal tract.
Target organsTarget organsTarget organsTarget organs Eyes. Skin. Upper respiratory tract.Chronic effectsChronic effectsChronic effectsChronic effects None known.Potential environmental effectsPotential environmental effectsPotential environmental effectsPotential environmental effects The product components are not classified as environmentally hazardous. However, this does not
exclude the possibility that large or frequent spills can have a harmful or damaging effect on theenvironment.
ComponentsComponentsComponentsComponents CAS #CAS #CAS #CAS # PercentPercentPercentPercent
3333. . . . Composition Composition Composition Composition / / / / Information on IngredientsInformation on IngredientsInformation on IngredientsInformation on Ingredients
5949-29-1 99 - 100CITRIC ACID MONOHYDRATE
Composition commentsComposition commentsComposition commentsComposition comments CAS # 5949-29-1 can be described by the CAS # 77-92-9.
4444. . . . First Aid MeasuresFirst Aid MeasuresFirst Aid MeasuresFirst Aid MeasuresFirst aid proceduresFirst aid proceduresFirst aid proceduresFirst aid procedures
Eye contactEye contactEye contactEye contact Immediately flush with plenty of water for at least 15 minutes. If easy to do, remove contactlenses. Get medical attention immediately.
Skin contactSkin contactSkin contactSkin contact Immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Getmedical attention if irritation develops or persists.
InhalationInhalationInhalationInhalation Move to fresh air. Treat symptomatically. Call a physician if symptoms develop or persist.IngestionIngestionIngestionIngestion Drink plenty of water. Seek medical advice. If ingestion of a large amount does occur, call a
poison control center immediately.Material name: CITRIC ACID MONOHYDRATEMSDS ID: C4730 Version #: 02 Revision date: 06-17-2011
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Notes to physicianNotes to physicianNotes to physicianNotes to physician Treat symptomatically.General adviceGeneral adviceGeneral adviceGeneral advice Ensure that medical personnel are aware of the material(s) involved, and take precautions to
protect themselves. Show this safety data sheet to the doctor in attendance.
5555. . . . Fire Fighting MeasuresFire Fighting MeasuresFire Fighting MeasuresFire Fighting MeasuresFlammable propertiesFlammable propertiesFlammable propertiesFlammable properties Dust may form explosive mixture with air.
Extinguishing mediaExtinguishing mediaExtinguishing mediaExtinguishing mediaSuitable extinguishingSuitable extinguishingSuitable extinguishingSuitable extinguishingmediamediamediamedia
Water. Carbon dioxide (CO2). Dry chemical.
Unsuitable extinguishingUnsuitable extinguishingUnsuitable extinguishingUnsuitable extinguishingmediamediamediamedia
None known.
Protection of firefightersProtection of firefightersProtection of firefightersProtection of firefightersProtective equipment andProtective equipment andProtective equipment andProtective equipment andprecautions for firefightersprecautions for firefightersprecautions for firefightersprecautions for firefighters
Firefighters should wear full protective gear. Wear full protective clothing, including helmet,self-contained positive pressure or pressure demand breathing apparatus, protective clothing andface mask.
Special protective equipment forSpecial protective equipment forSpecial protective equipment forSpecial protective equipment forfire-fightersfire-fightersfire-fightersfire-fighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH(approved or equivalent) and full protective gear.
Specific methodsSpecific methodsSpecific methodsSpecific methods In the event of fire, cool tanks with water spray. In the event of fire and/or explosion do notbreathe fumes.
Hazardous combustion productsHazardous combustion productsHazardous combustion productsHazardous combustion products Carbon monoxide and carbon dioxide.
6666. . . . Accidental Release MeasuresAccidental Release MeasuresAccidental Release MeasuresAccidental Release MeasuresPersonal precautionsPersonal precautionsPersonal precautionsPersonal precautions Keep unnecessary personnel away. Keep upwind. Ventilate the area. Avoid inhalation of dust
from the spilled material. Do not touch damaged containers or spilled material unless wearingappropriate protective clothing.
Environmental precautionsEnvironmental precautionsEnvironmental precautionsEnvironmental precautions Prevent further leakage or spillage if safe to do so.Methods for containmentMethods for containmentMethods for containmentMethods for containment ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). If
sweeping of a contaminated area is necessary use a dust suppressant agent which does notreact with the product. Prevent entry into waterways, sewer, basements or confined areas.
Methods for cleaning upMethods for cleaning upMethods for cleaning upMethods for cleaning up Avoid dust formation.
Small Spills: Sweep up or vacuum up spillage and collect in suitable container for disposal.
Large Spills: Collect dust or particulates using a vacuum cleaner with a HEPA filter. Reduceairborne dust and prevent scattering by moistening with water.
Never return spills in original containers for re-use. Clean contaminated surface thoroughly. Cleanup in accordance with all applicable regulations.
7777. . . . Handling and StorageHandling and StorageHandling and StorageHandling and StorageHandlingHandlingHandlingHandling Keep formation of airborne dusts to a minimum. Dust may form explosive mixture with air. Avoid
heat, sparks, open flames and other ignition sources. Avoid breathing dust. Do not get in eyesand avoid contact with skin and clothing. Use only with adequate ventilation. Wash thoroughlyafter handling. Keep container closed. Wear appropriate personal protective equipment. SeeSection 8 of the MSDS for Personal Protective Equipment.
StorageStorageStorageStorage Keep containers tightly closed in a dry, cool and well-ventilated place.
8888. . . . Exposure Controls Exposure Controls Exposure Controls Exposure Controls / / / / Personal ProtectionPersonal ProtectionPersonal ProtectionPersonal ProtectionExposure guidelinesExposure guidelinesExposure guidelinesExposure guidelines Not established.Engineering controlsEngineering controlsEngineering controlsEngineering controls Good general ventilation (typically 10 air changes per hour) should be used. Ventilation rates
should be matched to conditions. If applicable, use process enclosures, local exhaust ventilation,or other engineering controls to maintain airborne levels below recommended exposure limits. Ifexposure limits have not been established, maintain airborne levels to an acceptable level.
Personal protective equipmentPersonal protective equipmentPersonal protective equipmentPersonal protective equipmentEye / face protectionEye / face protectionEye / face protectionEye / face protection Wear safety glasses with side shields (or goggles) and a face shield.
Material name: CITRIC ACID MONOHYDRATEMSDS ID: C4730 Version #: 02 Revision date: 06-17-2011
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Skin protectionSkin protectionSkin protectionSkin protection Wear appropriate chemical resistant clothing. Wear appropriate chemical resistant gloves.Respiratory protectionRespiratory protectionRespiratory protectionRespiratory protection If engineering controls do not maintain airborne concentrations below recommended exposure
limits (where applicable) or to an acceptable level (in countries where exposure limits have notbeen established), an approved respirator must be worn. Respirator type: High-efficiencyparticulate respirator with full facepiece.
General hygeineGeneral hygeineGeneral hygeineGeneral hygeineconsiderationsconsiderationsconsiderationsconsiderations
Provide eyewash station and safety shower. Always observe good personal hygiene measures,such as washing after handling the material and before eating, drinking, and/or smoking.Routinely wash work clothing and protective equipment to remove contaminants.
9999. . . . Physical & Chemical PropertiesPhysical & Chemical PropertiesPhysical & Chemical PropertiesPhysical & Chemical PropertiesAppearanceAppearanceAppearanceAppearance Granular.
ColorColorColorColor White.
OdorOdorOdorOdor Odorless.
Odor thresholdOdor thresholdOdor thresholdOdor threshold Not available.
Physical statePhysical statePhysical statePhysical state Solid.
FormFormFormForm Powder.
pHpHpHpH 2.2 (0.1 N Solution)
Melting pointMelting pointMelting pointMelting point 275 - 305.6 °F (135 - 152 °C)
Freezing pointFreezing pointFreezing pointFreezing point 275 - 305.6 °F (135 - 152 °C)
Boiling pointBoiling pointBoiling pointBoiling point Decomposes
Flash pointFlash pointFlash pointFlash point Not available.
Evaporation rateEvaporation rateEvaporation rateEvaporation rate Not available.
Flammability limits in air, upper,Flammability limits in air, upper,Flammability limits in air, upper,Flammability limits in air, upper,% by volume% by volume% by volume% by volume
Not available.
Flammability limits in air, lower,Flammability limits in air, lower,Flammability limits in air, lower,Flammability limits in air, lower,% by volume% by volume% by volume% by volume
Not available.
Vapor densityVapor densityVapor densityVapor density Not available.
Specific gravitySpecific gravitySpecific gravitySpecific gravity 1.542
Relative densityRelative densityRelative densityRelative density Not available.
Solubility (water)Solubility (water)Solubility (water)Solubility (water) Soluble
Partition coefficientPartition coefficientPartition coefficientPartition coefficient(n-octanol/water)(n-octanol/water)(n-octanol/water)(n-octanol/water)
Not available
Auto-ignition temperatureAuto-ignition temperatureAuto-ignition temperatureAuto-ignition temperature 1850 °F (1010 °C)
Molecular weightMolecular weightMolecular weightMolecular weight 210.14 g/mol
Molecular formulaMolecular formulaMolecular formulaMolecular formula C6-H10-O8
10101010. . . . Chemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical stabilityChemical stabilityChemical stabilityChemical stability Stable under normal temperature conditions.Conditions to avoidConditions to avoidConditions to avoidConditions to avoid Avoid dust formation. Excessive heat. Exposure to moisture.Incompatible materialsIncompatible materialsIncompatible materialsIncompatible materials Strong oxidizing agents.Hazardous decompositionHazardous decompositionHazardous decompositionHazardous decompositionproductsproductsproductsproducts
Carbon Dioxide. Carbon monoxide.
Possibility of hazardousPossibility of hazardousPossibility of hazardousPossibility of hazardousreactionsreactionsreactionsreactions
Hazardous polymerization does not occur.
Toxicological dataToxicological dataToxicological dataToxicological data
11111111. . . . Toxicological InformationToxicological InformationToxicological InformationToxicological Information
ProductProductProductProduct Test ResultsTest ResultsTest ResultsTest ResultsAcute Oral LD50 Rat: 6730 mg/kgCITRIC ACID MONOHYDRATE (5949-29-1)
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SensitizationSensitizationSensitizationSensitization Not a skin sensitizer.
Local effectsLocal effectsLocal effectsLocal effects Severe eye irritation. May cause burns. Irritating to respiratory system and skin.
Chronic effectsChronic effectsChronic effectsChronic effects None known.
CarcinogenicityCarcinogenicityCarcinogenicityCarcinogenicity This product is not considered to be a carcinogen by IARC, ACGIH, NTP, or OSHA.
Skin corrosion/irritationSkin corrosion/irritationSkin corrosion/irritationSkin corrosion/irritation Causes skin irritation.
EpidemiologyEpidemiologyEpidemiologyEpidemiology No epidemiological data is available for this product.
MutagenicityMutagenicityMutagenicityMutagenicity No data available to indicate product or any components present at greater than 0.1% aremutagenic or genotoxic.
Neurological effectsNeurological effectsNeurological effectsNeurological effects None known.
Reproductive effectsReproductive effectsReproductive effectsReproductive effects Contains no ingredient listed as toxic to reproduction
TeratogenicityTeratogenicityTeratogenicityTeratogenicity No data available to indicate product or any components present at greater than 0.1% may causebirth defects.
Symptoms and targetSymptoms and targetSymptoms and targetSymptoms and targetorgansorgansorgansorgans
Irritant effects.
Ecotoxicological dataEcotoxicological dataEcotoxicological dataEcotoxicological data
12121212. . . . Ecological InformationEcological InformationEcological InformationEcological Information
ProductProductProductProduct Test ResultsTest ResultsTest ResultsTest Results
LC50 Green or Europeon shore crab (Carcinus maenas): 160mg/l 48.00 hours
CITRIC ACID MONOHYDRATE (5949-29-1)
EcotoxicityEcotoxicityEcotoxicityEcotoxicity This product has no known eco-toxicological effects.
Environmental effectsEnvironmental effectsEnvironmental effectsEnvironmental effects Ecological injuries are not known or expected under normal use. An environmental hazard cannotbe excluded in the event of unprofessional handling or disposal.
Persistence andPersistence andPersistence andPersistence anddegradabilitydegradabilitydegradabilitydegradability
This material is readily biodegraded and is not likely to bioconcentrate.
Partition coefficientPartition coefficientPartition coefficientPartition coefficient(n-octanol/water)(n-octanol/water)(n-octanol/water)(n-octanol/water)
Not available
13131313. . . . Disposal ConsiderationsDisposal ConsiderationsDisposal ConsiderationsDisposal ConsiderationsDisposal instructionsDisposal instructionsDisposal instructionsDisposal instructions Dispose of contents/container in accordance with local/regional/national/international regulations.Contaminated packagingContaminated packagingContaminated packagingContaminated packaging Offer rinsed packaging material to local recycling facilities. Since emptied containers retain
product residue, follow label warnings even after container is emptied.
14141414. . . . Transport InformationTransport InformationTransport InformationTransport InformationDOTDOTDOTDOTNot regulated as dangerous goods.
IATAIATAIATAIATANot regulated as dangerous goods.
IMDGIMDGIMDGIMDGNot regulated as dangerous goods.
15151515. . . . Regulatory InformationRegulatory InformationRegulatory InformationRegulatory InformationUS federal regulationsUS federal regulationsUS federal regulationsUS federal regulations This product is a "Hazardous Chemical" as defined by the OSHA Hazard Communication
Standard, 29 CFR 1910.1200.CERCLA/SARA Hazardous Substances - Not applicable.
This product is not listed on the U.S. EPA TSCA Inventory. Under TSCA, hydrates areconsidered mixtures of their anhydrous salt and water. Accordingly, the anhydrous form issubject to TSCA reporting requirements.
CERCLA (Superfund) reportable quantityCERCLA (Superfund) reportable quantityCERCLA (Superfund) reportable quantityCERCLA (Superfund) reportable quantityNone
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Superfund Amendments and Reauthorization Act of 1986 (SARA)Superfund Amendments and Reauthorization Act of 1986 (SARA)Superfund Amendments and Reauthorization Act of 1986 (SARA)Superfund Amendments and Reauthorization Act of 1986 (SARA)Hazard categoriesHazard categoriesHazard categoriesHazard categories Immediate Hazard - Yes
Delayed Hazard - NoFire Hazard - NoPressure Hazard - NoReactivity Hazard - No
Section 311 hazardousSection 311 hazardousSection 311 hazardousSection 311 hazardouschemicalchemicalchemicalchemical
Yes
Food and Drug AdministrationFood and Drug AdministrationFood and Drug AdministrationFood and Drug Administration(FDA)(FDA)(FDA)(FDA)
Total food additiveDirect food additiveGRAS food additive
Inventory statusInventory statusInventory statusInventory statusCountryCountryCountryCountry((((ssss) ) ) ) or regionor regionor regionor region Inventory nameInventory nameInventory nameInventory name On inventory On inventory On inventory On inventory ((((yesyesyesyes////nononono)*)*)*)*
YesAustralia Australian Inventory of Chemical Substances (AICS)YesCanada Domestic Substances List (DSL)NoCanada Non-Domestic Substances List (NDSL)
YesChina Inventory of Existing Chemical Substances in China (IECSC)YesEurope European Inventory of Existing Commercial Chemical
Substances (EINECS)NoEurope European List of Notified Chemical Substances (ELINCS)
YesJapan Inventory of Existing and New Chemical Substances (ENCS)YesKorea Existing Chemicals List (ECL)YesNew Zealand New Zealand InventoryYesPhilippines Philippine Inventory of Chemicals and Chemical Substances
(PICCS)NoUnited States & Puerto Rico Toxic Substances Control Act (TSCA) Inventory
*A "Yes" indicates that all components of this product comply with the inventory requirements administered by the governing country(s)
State regulationsState regulationsState regulationsState regulations This product does not contain a chemical known to the State of California to cause cancer, birthdefects or other reproductive harm.
Saf-T-DataSaf-T-DataSaf-T-DataSaf-T-Data Health: 1 - SlightFlammability: 2 - ModerateReactivity: 1 - SlightContact: 3 - SevereLab Protective Equip: D - GOGGLES & SHIELD; LAB COAT & APRON; VENT HOOD; PROPERGLOVESStorage Color Code: G - Green (General Storage)
16161616. . . . Labeling InfoLabeling InfoLabeling InfoLabeling InfoLabel Hazard WarningLabel Hazard WarningLabel Hazard WarningLabel Hazard Warning DANGER
Contact will irritate or burn eyes. Irritating to respiratory system and skin.Label PrecautionsLabel PrecautionsLabel PrecautionsLabel Precautions Keep away from heat, sparks and flame. Avoid breathing dust. Do not get in eyes and avoid
contact with skin and clothing. Use only with adequate ventilation. Wash thoroughly afterhandling. Keep container closed.
Label First AidLabel First AidLabel First AidLabel First Aid Immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention. Flushskin thoroughly with water. If gas/fume/vapor/dust/mist from the material is inhaled, remove theaffected person immediately to fresh air. Get medical attention if irritation develops or persists. Ifingestion of a large amount does occur, call a poison control center immediately.
17171717. . . . Other InformationOther InformationOther InformationOther InformationNFPA ratingsNFPA ratingsNFPA ratingsNFPA ratings Health: 2
Flammability: 1Instability: 0
Material name: CITRIC ACID MONOHYDRATEMSDS ID: C4730 Version #: 02 Revision date: 06-17-2011
MSDS US COV
5 / 6
DisclaimerDisclaimerDisclaimerDisclaimer THE INFORMATION PRESENTED IN THIS MATERIAL SAFETY DATA SHEET (MSDS/SDS)WAS PREPARED BY TECHNICAL PERSONNEL BASED ON DATA THAT THEY BELIEVE INTHEIR GOOD FAITH JUDGMENT IS ACCURATE. HOWEVER, THE INFORMATION PROVIDEDHEREIN IS PROVIDED “AS IS,” AND AVANTOR PERFORMANCE MATERIALS MAKES ANDGIVES NO REPRESENTATIONS OR WARRANTIES WHATSOEVER, AND EXPRESSLYDISCLAIMS ALL WARRANTIES REGARDING SUCH INFORMATION AND THE PRODUCT TOWHICH IT RELATES, WHETHER EXPRESS, IMPLIED, OR STATUTORY, INCLUDINGWITHOUT LIMITATION, WARRANTIES OF ACCURACY, COMPLETENESS,MERCHANTABILITY, NON-INFRINGEMENT, PERFORMANCE, SAFETY, SUITABILITY,STABILITY, AND FITNESS FOR A PARTICULAR PURPOSE, AND ANY WARRANTIES ARISINGFROM COURSE OF DEALING, COURSE OF PERFORMANCE, OR USAGE OF TRADE. THISMSDS/SDS IS INTENDED ONLY AS A GUIDE TO THE APPROPRIATE PRECAUTIONARYHANDLING OF THE MATERIAL BY A PROPERLY TRAINED PERSON USING THIS PRODUCT,AND IS NOT INTENDED TO BE COMPREHENSIVE AS TO THE MANNER AND CONDITIONSOF USE, HANDLING, STORAGE, OR DISPOSAL OF THE PRODUCT. INDIVIDUALSRECEIVING THIS MSDS/SDS MUST ALWAYS EXERCISE THEIR OWN INDEPENDENTJUDGMENT IN DETERMINING THE APPROPRIATENESS OF SUCH ISSUES. ACCORDINGLY,AVANTOR PERFORMANCE MATERIALS ASSUMES NO LIABILITY WHATSOEVER FOR THEUSE OF OR RELIANCE UPON THIS INFORMATION. NO SUGGESTIONS FOR USE AREINTENDED AS, AND NOTHING HEREIN SHALL BE CONSTRUED AS, A RECOMMENDATIONTO INFRINGE ANY EXISTING PATENTS OR TO VIOLATE ANY FEDERAL, STATE, LOCAL, ORFOREIGN LAWS. AVANTOR PERFORMANCE MATERIALS REMINDS YOU THAT IT IS YOURLEGAL DUTY TO MAKE ALL INFORMATION IN THIS MSDS/SDS AVAILABLE TO YOUREMPLOYEES.
Issue dateIssue dateIssue dateIssue date 06-17-2011This data sheet containsThis data sheet containsThis data sheet containsThis data sheet containschanges from the previouschanges from the previouschanges from the previouschanges from the previousversion in section(s):version in section(s):version in section(s):version in section(s):
This document has undergone significant changes and should be reviewed in its entirety.
Material name: CITRIC ACID MONOHYDRATEMSDS ID: C4730 Version #: 02 Revision date: 06-17-2011
MSDS US COV
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SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Date of issue: 16.02.2017 Version 1.0
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 14
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 819040
Product name Ethylenediaminetetraacetic acid dipotassium salt dihydrate for
synthesis
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.
CAS-No. 25102-12-9
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Chemical for synthesis
For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * 8th Floor, Godrej One,
Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079
India * Tel: 0091 22 6210 9000
Responsible Department Quality Assurance * Merck Life Science Private Limited *
e-mail: [email protected] *
Tel : +91-2267863131-6
1.4 Emergency telephone
number
Please contact the regional company representation in your country.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 819040
Product name Ethylenediaminetetraacetic acid dipotassium salt dihydrate for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 14
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
Classification (REGULATION (EC) No 1272/2008)
Acute toxicity, Category 4, Inhalation, H332
Specific target organ toxicity - repeated exposure, Category 2, Inhalation, Respiratory Tract, H373
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Hazard pictograms
Signal word
Warning
Hazard statements
H332 Harmful if inhaled.
H373 May cause damage to organs (Respiratory Tract) through prolonged or repeated exposure if
inhaled.
Precautionary statements
Response
P314 Get medical advice/ attention if you feel unwell.
Reduced labelling (≤125 ml)
Hazard pictograms
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 819040
Product name Ethylenediaminetetraacetic acid dipotassium salt dihydrate for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 14
Signal word
Warning
Contains: ethylenediaminetetraacetic acid dipotassium salt dihydrate
CAS-No. 25102-12-9
2.3 Other hazards
None known.
SECTION 3. Composition/information on ingredients
3.1 Substance
Formula C₁₀H₁₄K₂N₂O₈ * 2H₂O (Hill)
EC-No. 217-895-0
Molar mass 404.47 g/mol
Hazardous components (REGULATION (EC) No 1272/2008)
Chemical name (Concentration)
CAS-No. Registration number Classification
ethylenediaminetetraacetic acid dipotassium salt dihydrate (<= 100 % )
25102-12-9 *)
Acute toxicity, Category 4, H332
Specific target organ toxicity - repeated exposure, Category 2,
H373
*) A registration number is not available for this substance as the substance or its use are exempted from registration according to Article
2 REACH Regulation (EC) No 1907/2006, the annual tonnage does not require a registration or the registration is envisaged for a later
registration deadline.
For the full text of the H-Statements mentioned in this Section, see Section 16.
3.2 Mixture
Not applicable
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 819040
Product name Ethylenediaminetetraacetic acid dipotassium salt dihydrate for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 4 of 14
SECTION 4. First aid measures
4.1 Description of first aid measures
After inhalation: fresh air. Call in physician. If breathing stops: immediately apply artificial
respiration, if necessary also oxygen.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower. Consult a physician.
After eye contact: rinse out with plenty of water. Remove contact lenses. Call in ophthalmologist.
After swallowing: immediately make victim drink water (two glasses at most). Consult a
physician.
4.2 Most important symptoms and effects, both acute and delayed
irritant effects
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SECTION 5. Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Water, Foam, Carbon dioxide (CO2), Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Combustible.
Development of hazardous combustion gases or vapours possible in the event of fire.
Fire may cause evolution of:
nitrogen oxides
5.3 Advice for firefighters
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 819040
Product name Ethylenediaminetetraacetic acid dipotassium salt dihydrate for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 5 of 14
Special protective equipment for firefighters
In the event of fire, wear self-contained breathing apparatus.
Further information
Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing
water from contaminating surface water or the ground water system.
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact. Ensure
adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an
expert.
Advice for emergency responders:
Protective equipment see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills.
Observe possible material restrictions (see sections 7 and 10).
Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.
6.4 Reference to other sections
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handling
Observe label precautions.
Work under hood. Do not inhale substance/mixture.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 819040
Product name Ethylenediaminetetraacetic acid dipotassium salt dihydrate for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 6 of 14
Hygiene measures
Change contaminated clothing. Preventive skin protection recommended. Wash hands after
working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed. Dry.
Recommended storage temperature see product label.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
Contains no substances with occupational exposure limit values.
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Eye/face protection
Safety glasses
Hand protection
full contact:
Glove material: Nitrile rubber
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 819040
Product name Ethylenediaminetetraacetic acid dipotassium salt dihydrate for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 7 of 14
Glove thickness: 0.11 mm
Break through time: > 480 min
splash contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 741 Dermatril® L (full contact),
KCL 741 Dermatril® L (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Other protective equipment
protective clothing
Respiratory protection
required when dusts are generated.
Recommended Filter type: Filter P 2 (acc. to DIN 3181) for solid and liquid particles of harmful
substances
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
Environmental exposure controls
Do not let product enter drains.
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
Form solid
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 819040
Product name Ethylenediaminetetraacetic acid dipotassium salt dihydrate for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 8 of 14
Colour white
Odour odourless
Odour Threshold Not applicable
pH 4 - 5
at 50 g/l
20 °C
Melting point 272 °C
Boiling point/boiling range Not applicable, (decomposition)
Flash point No information available.
Evaporation rate No information available.
Flammability (solid, gas) No information available.
Lower explosion limit No information available.
Upper explosion limit No information available.
Vapour pressure at 20 °C
low
Relative vapour density No information available.
Density No information available.
Relative density No information available.
Water solubility at 20 °C
soluble
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 819040
Product name Ethylenediaminetetraacetic acid dipotassium salt dihydrate for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 9 of 14
Partition coefficient: n-
octanol/water
No information available.
Auto-ignition temperature No information available.
Decomposition temperature No information available.
Viscosity, dynamic No information available.
Explosive properties Not classified as explosive.
Oxidizing properties none
9.2 Other data
Bulk density ca.310 kg/m3
SECTION 10. Stability and reactivity
10.1 Reactivity
The following applies in general to flammable organic substances and mixtures: in
correspondingly fine distribution, when whirled up a dust explosion potential may generally be
assumed.
10.2 Chemical stability
releases water of crystallisation when heated.
The product is chemically stable under standard ambient conditions (room temperature) .
10.3 Possibility of hazardous reactions
Caution! In contact with nitrites, nitrates, nitrous acid possible liberation of nitrosamines!
10.4 Conditions to avoid
Strong heating (decomposition).
10.5 Incompatible materials
no information available
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 819040
Product name Ethylenediaminetetraacetic acid dipotassium salt dihydrate for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 10 of 14
10.6 Hazardous decomposition products
in the event of fire: See section 5.
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Acute oral toxicity
LD50 Rat: > 2,000 mg/kg
(External MSDS)
Acute inhalation toxicity
Acute toxicity estimate: 1.6 mg/l; dust/mist
Expert judgement
The value is given in analogy to the following substances: Ethylenedinitrilotetraacetic acid
disodium salt
Acute dermal toxicity
This information is not available.
Skin irritation
slight irritation
Eye irritation
slight irritation
Sensitisation
This information is not available.
Germ cell mutagenicity
This information is not available.
Carcinogenicity
This information is not available.
Reproductive toxicity
This information is not available.
Teratogenicity
This information is not available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 819040
Product name Ethylenediaminetetraacetic acid dipotassium salt dihydrate for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 11 of 14
Specific target organ toxicity - single exposure
This information is not available.
Specific target organ toxicity - repeated exposure
May cause damage to organs through prolonged or repeated exposure.
Exposure routes: Inhalation
Target Organs: Respiratory Tract
The value is given in analogy to the following substances: Ethylenedinitrilotetraacetic acid
disodium salt
Aspiration hazard
This information is not available.
11.2 Further information
After uptake of large quantities:
Damage to:
Kidney
Under given conditions, contact with nitrites or nitric acid can lead to the formation of
nitrosamines, which have shown themselves to be carcinogenic in animal experiments.
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
SECTION 12. Ecological information
12.1 Toxicity
No information available.
12.2 Persistence and degradability
Biodegradability
Not readily biodegradable.
12.3 Bioaccumulative potential
No information available.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 819040
Product name Ethylenediaminetetraacetic acid dipotassium salt dihydrate for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 12 of 14
12.6 Other adverse effects
Discharge into the environment must be avoided.
SECTION 13. Disposal considerations
Waste treatment methods
Waste material must be disposed of in accordance with the national and local regulations. Leave
chemicals in original containers. No mixing with other waste. Handle uncleaned containers like
the product itself.
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Sea transport (IMDG)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 819040
Product name Ethylenediaminetetraacetic acid dipotassium salt dihydrate for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 13 of 14
National legislation
Storage class 10 - 13
15.2 Chemical safety assessment
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Full text of H-Statements referred to under sections 2 and 3.
H332 Harmful if inhaled.
H373 May cause damage to organs through prolonged or repeated
exposure if inhaled.
Training advice
Provide adequate information, instruction and training for operators.
Labelling
Hazard pictograms
Signal word
Warning
Hazard statements
H332 Harmful if inhaled.
H373 May cause damage to organs (Respiratory Tract) through prolonged or repeated exposure if
inhaled.
Precautionary statements
Response
P314 Get medical advice/ attention if you feel unwell.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 819040
Product name Ethylenediaminetetraacetic acid dipotassium salt dihydrate for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 14 of 14
Contains: ethylenediaminetetraacetic acid dipotassium salt dihydrate
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Revision Date 10.11.2017 Version 1.4
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 17
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 102539
Product name Cobalt(II) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph
Eur
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.
CAS-No. 7791-13-1
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Reagent for analysis
For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * 8th Floor, Godrej One,
Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079
India * Tel: 0091 22 6210 9000
Responsible Department Quality Assurance * Merck Life Science Private Limited *
e-mail: [email protected] *
Tel : +91-2267863131-6
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102539
Product name Cobalt(II) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 17
1.4 Emergency telephone
number
Please contact the regional company representation in your country.
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
Classification (REGULATION (EC) No 1272/2008)
Acute toxicity, Category 4, Oral, H302
Respiratory sensitisation, Category 1, H334
Skin sensitisation, Category 1, H317
Germ cell mutagenicity, Category 2, H341
Carcinogenicity, Category 1B, Inhalation, H350i
Reproductive toxicity, Category 1B, H360F
Acute aquatic toxicity, Category 1, H400
Chronic aquatic toxicity, Category 1, H410
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Hazard pictograms
Signal word
Danger
Hazard statements
H350i May cause cancer by inhalation.
H360F May damage fertility.
H302 Harmful if swallowed.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102539
Product name Cobalt(II) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 17
H317 May cause an allergic skin reaction.
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H341 Suspected of causing genetic defects.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statements
Prevention
P201 Obtain special instructions before use.
P273 Avoid release to the environment.
P280 Wear protective gloves.
Response
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for
breathing.
P342 + P311 If experiencing respiratory symptoms: Call a POISON CENTER/doctor.
Restricted to professional users.
Reduced labelling (≤125 ml)
Hazard pictograms
Signal word
Danger
Hazard statements
H350i May cause cancer by inhalation.
H360F May damage fertility.
H317 May cause an allergic skin reaction.
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H341 Suspected of causing genetic defects.
Precautionary statements
P201 Obtain special instructions before use.
P280 Wear protective gloves.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P341 IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102539
Product name Cobalt(II) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 4 of 17
for breathing.
P308 + P313 IF exposed or concerned: Get medical advice/ attention.
CAS-No. 7791-13-1
2.3 Other hazards
None known.
SECTION 3. Composition/information on ingredients
3.1 Substance
Formula Cl₂Co * 6 H₂O Cl₂Co * 6 H₂O (Hill)
EC-No. 231-589-4
Molar mass 237.90 g/mol
Hazardous components (REGULATION (EC) No 1272/2008)
Chemical name (Concentration)
CAS-No. Registration number Classification
Cobalt(II) chloride hexahydrate (>= 20 % - < 25 % )
7791-13-1 *)
Acute toxicity, Category 4, H302
Respiratory sensitisation, Category 1, H334
Skin sensitisation, Category 1, H317
Germ cell mutagenicity, Category 2, H341
Carcinogenicity, Category 1B, H350i
Reproductive toxicity, Category 1B, H360F
Acute aquatic toxicity, Category 1, H400
Chronic aquatic toxicity, Category 1, H410
M-Factor: 10
*) A registration number is not available for this substance as the substance or its use are exempted from registration according to Article
2 REACH Regulation (EC) No 1907/2006, the annual tonnage does not require a registration or the registration is envisaged for a later
registration deadline.
For the full text of the H-Statements mentioned in this Section, see Section 16.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102539
Product name Cobalt(II) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 5 of 17
3.2 Mixture
Not applicable
SECTION 4. First aid measures
4.1 Description of first aid measures
General advice
First aider needs to protect himself.
After inhalation: fresh air. Call in physician.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower. Consult a physician.
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.
After swallowing: immediately make victim drink water (two glasses at most). Consult a
physician.
4.2 Most important symptoms and effects, both acute and delayed
Allergic reactions, irritant effects, Diarrhoea, Tremors
Symptoms of an acute cobalt intoxication: diarrhoea, loss of appetite, drop in body temperature,
drop in blood pressure. Toxic effect on kidneys (proteinuria, anuria), heart, and pancreas.
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SECTION 5. Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Use extinguishing measures that are appropriate to local circumstances and the surrounding
environment.
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102539
Product name Cobalt(II) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 6 of 17
5.2 Special hazards arising from the substance or mixture
Not combustible.
Ambient fire may liberate hazardous vapours.
Fire may cause evolution of:
Hydrogen chloride gas
5.3 Advice for firefighters
Special protective equipment for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.
Further information
Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing
water from contaminating surface water or the ground water system.
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid generation and inhalation of dusts in all
circumstances. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger
area, observe emergency procedures, consult an expert.
Advice for emergency responders:
Protective equipment see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see
sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area. Avoid
generation of dusts.
6.4 Reference to other sections
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102539
Product name Cobalt(II) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 7 of 17
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handling
Observe label precautions.
Work under hood. Do not inhale substance/mixture.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and
face after working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only
to qualified or authorised persons.
Recommended storage temperature see product label.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
Contains no substances with occupational exposure limit values.
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102539
Product name Cobalt(II) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 8 of 17
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Eye/face protection
Safety glasses
Hand protection
full contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
splash contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 741 Dermatril® L (full contact),
KCL 741 Dermatril® L (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Other protective equipment
protective clothing
Respiratory protection
required when dusts are generated.
Recommended Filter type: Filter P 3 (acc. to DIN 3181) for solid and liquid particles of toxic
and very toxic substances
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102539
Product name Cobalt(II) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 9 of 17
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
Environmental exposure controls
Do not let product enter drains.
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
Form solid
Colour violet
Odour odourless
Odour Threshold Not applicable
pH ca. 4.9
at 50 g/l
25 °C
Melting point 56 °C
Boiling point No information available.
Flash point Not applicable
Evaporation rate No information available.
Flammability (solid, gas) The product is not flammable.
Lower explosion limit No information available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102539
Product name Cobalt(II) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 10 of 17
Upper explosion limit No information available.
Vapour pressure No information available.
Relative vapour density No information available.
Density 1.92 g/cm3
at 25 °C
Relative density No information available.
Water solubility 76 g/l
at 0 °C
191 g/l
at 100 °C
Partition coefficient: n-
octanol/water
No information available.
Auto-ignition temperature No information available.
Decomposition temperature No information available.
Viscosity, dynamic No information available.
Explosive properties Not classified as explosive.
Oxidizing properties none
9.2 Other data
Bulk density ca.1,250 kg/m3
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102539
Product name Cobalt(II) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 11 of 17
SECTION 10. Stability and reactivity
10.1 Reactivity
See section 10.3
10.2 Chemical stability
releases water of crystallisation when heated.
The product is chemically stable under standard ambient conditions (room temperature) .
10.3 Possibility of hazardous reactions
Risk of explosion with:
Alkali metals
10.4 Conditions to avoid
no information available
10.5 Incompatible materials
no information available
10.6 Hazardous decomposition products
in the event of fire: See section 5.
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Acute oral toxicity
LD50 Rat: 766 mg/kg
(RTECS)
Symptoms: Tremors, Diarrhoea
Acute inhalation toxicity
Symptoms: Irritation symptoms in the respiratory tract.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102539
Product name Cobalt(II) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 12 of 17
Acute dermal toxicity
LD50 Rat: > 2,000 mg/kg
(RTECS) Tricobalt tetraoxide
Skin irritation
Possible damages: slight irritation
Eye irritation
Possible damages: slight irritation
Sensitisation
May cause allergy or asthma symptoms or breathing difficulties if inhaled.
May cause an allergic skin reaction.
Germ cell mutagenicity
This information is not available.
Carcinogenicity
This information is not available.
Reproductive toxicity
This information is not available.
Teratogenicity
This information is not available.
CMR effects
Carcinogenicity:
May cause cancer by inhalation.
Mutagenicity:
Suspected of causing genetic defects.
Reproductive toxicity:
May damage fertility.
Specific target organ toxicity - single exposure
This information is not available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102539
Product name Cobalt(II) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 13 of 17
Specific target organ toxicity - repeated exposure
This information is not available.
Aspiration hazard
This information is not available.
11.2 Further information
Symptoms of an acute cobalt intoxication: diarrhoea, loss of appetite, drop in body temperature,
drop in blood pressure. Toxic effect on kidneys (proteinuria, anuria), heart, and pancreas.
Other dangerous properties can not be excluded.
This substance should be handled with particular care.
SECTION 12. Ecological information
12.1 Toxicity
No information available.
12.2 Persistence and degradability
No information available.
12.3 Bioaccumulative potential
No information available.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.
12.6 Other adverse effects
Additional ecological information
Discharge into the environment must be avoided.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102539
Product name Cobalt(II) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 14 of 17
SECTION 13. Disposal considerations
Waste treatment methods
Waste material must be disposed of in accordance with the national and local regulations. Leave
chemicals in original containers. No mixing with other waste. Handle uncleaned containers like
the product itself.
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 UN number UN 3077
14.2 Proper shipping name ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID,
N.O.S. (COBALT DICHLORIDE)
14.3 Class 9
14.4 Packing group III
14.5 Environmentally hazardous yes
14.6 Special precautions for
user
yes
Tunnel restriction code -
Packages smaller than or equal to 5 kg / L , not dangerous goods of Class 9
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102539
Product name Cobalt(II) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 15 of 17
14.1 UN number UN 3077
14.2 Proper shipping name ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID,
N.O.S. (COBALT DICHLORIDE)
14.3 Class 9
14.4 Packing group III
14.5 Environmentally hazardous yes
14.6 Special precautions for
user
no
Packages smaller than or equal to 5 kg / L , not dangerous goods of Class 9
Sea transport (IMDG)
14.1 UN number UN 3077
14.2 Proper shipping name ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID,
N.O.S. (COBALT DICHLORIDE)
14.3 Class 9
14.4 Packing group III
14.5 Environmentally hazardous yes
14.6 Special precautions for
user
yes
EmS F-A S-F
Packages smaller than or equal to 5 kg / L , not dangerous goods of Class 9
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National legislation
Storage class 6.1 D
15.2 Chemical safety assessment
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102539
Product name Cobalt(II) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 16 of 17
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Full text of H-Statements referred to under sections 2 and 3.
H302 Harmful if swallowed.
H317 May cause an allergic skin reaction.
H334 May cause allergy or asthma symptoms or breathing difficulties if
inhaled.
H341 Suspected of causing genetic defects.
H350i May cause cancer by inhalation.
H360F May damage fertility.
H400 Very toxic to aquatic life.
H410 Very toxic to aquatic life with long lasting effects.
Training advice
Provide adequate information, instruction and training for operators.
Labelling
Hazard pictograms
Signal word
Danger
Hazard statements
H302 Harmful if swallowed.
H317 May cause an allergic skin reaction.
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H341 Suspected of causing genetic defects.
H350i May cause cancer by inhalation.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102539
Product name Cobalt(II) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 17 of 17
H360 May damage fertility or the unborn child.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statements
Prevention
P201 Obtain special instructions before use.
P273 Avoid release to the environment.
P280 Wear protective gloves.
Response
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for
breathing.
P342 + P311 If experiencing respiratory symptoms: Call a POISON CENTER/doctor.
Further information
Restricted to professional users.
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
Manganese chloride tetrahydrate
Manganese dichloride tetrahydrate; Manganous chloridetetrahydrate
Manganese (II) Chloride, tetrahydrate
MnCl2.4H2O
Not available.
OO9625000
13446-34-9
M1105, M1106, M1109
Not available.
SPECTRUM LABORATORY PRODUCTS INC.14422 S. SAN PEDRO STREETGARDENA, CA 90248
CALL (310) 516-8000
SPECTRUM LABORATORY PRODUCTS INC.14422 S. SAN PEDRO STREETGARDENA, CA 90248
01 0
Material Safety Data SheetNFPA HMIS Personal Protective Equipment
Section 1. Chemical Product and Company Identification
Common Name/Trade Name
CatalogNumber(s).
CAS#
RTECS
CI#
Manufacturer
Synonym
Chemical Name
Chemical Family
IN CASE OF EMERGENCYCHEMTREC (24hr) 800-424-9300
Chemical Formula
Supplier
See Section 15.
Commercial Name(s) Not available.
TSCA TSCA 8(b) inventory: Nop r o d u c t s w e r e f o u n d .Exempt from listing on TSCA8(b) inventory since it is ahydrate
1
0
0
Health Hazard
Fire Hazard
Reactivity
Page Number: 1
Manganese chloride tetrahydrate: ORAL (LD50): Acute: 1484 mg/kg [Rat].
1) Manganese chloride tetrahydrate 13446-34-9 1 3 100
Toxicological Dataon Ingredients
Name
Section 2.Composition and Information on Ingredients
Exposure Limits
TWA (mg/m3) STEL (mg/m3) CEIL (mg/m3) % by WeightCAS #
Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation.
CARCINOGENIC EFFECTS: Not available.MUTAGENIC EFFECTS: Not available.TERATOGENIC EFFECTS: Not available.DEVELOPMENTAL TOXICITY: Not available.The substance may be toxic to lungs, central nervous system (CNS).Repeated or prolonged exposure to the substance can produce target organs damage.
Section 3. Hazards Identification
Potential Acute Health Effects
Potential Chronic HealthEffects
Continued on Next Page
Manganese chloride tetrahydrate Page Number: 2
Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to anunconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosentight clothing such as a collar, tie, belt or waistband.
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water forat least 15 minutes. Cold water may be used. Get medical attention if irritation occurs.
Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritationdevelops. Cold water may be used.
Not available.
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.Get medical attention.
Not available.
Not available.
Section 4. First Aid Measures
Eye Contact
Skin Contact
Serious Skin Contact
Inhalation
Serious Inhalation
Ingestion
Serious Ingestion
Not applicable.
Non-flammable.
Not available.
Not applicable.
Not applicable.
Not applicable.
Not applicable.
When heated to decomposition it emits toxic fumes of hydrogen chloride.
Risks of explosion of the product in presence of mechanical impact: Not available.Risks of explosion of the product in presence of static discharge: Not available.
Not available.
Section 5. Fire and Explosion Data
Flammability of the Product
Auto-Ignition Temperature
Flash Points
Flammable Limits
Products of Combustion
Fire Hazards in Presence ofVarious Substances
Explosion Hazards in Presenceof Various Substances
Fire Fighting Mediaand Instructions
Special Remarks onFire Hazards
Special Remarks on ExplosionHazards
Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning byspreading water on the contaminated surface and dispose of according to local and regional authorityrequirements.
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreadingwater on the contaminated surface and allow to evacuate through the sanitary system. Be careful that theproduct is not present at a concentration level above TLV. Check TLV on the MSDS and with localauthorities.
Section 6. Accidental Release Measures
Small Spill
Large Spill
Continued on Next Page
Manganese chloride tetrahydrate Page Number: 3
Keep container tightly closed. Keep container in a cool, well-ventilated area.
Do not ingest. Do not breathe dust. Wear suitable protective clothing. If ingested, seek medical adviceimmediately and show the container or the label. Keep away from incompatibles such as metals.
Section 7. Handling and Storage
Precautions
Storage
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels belowrecommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keepexposure to airborne contaminants below the exposure limit.
Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.Gloves.
Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should beused to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult aspecialist BEFORE handling this product.
TWA: 5 (mg(Mn)/m3) [Australia] Inhalation Total.TWA: 5 (mg(Mn)/m3) from OSHA (PEL) [United States] Inhalation Total.TWA: 0.2 (mg(Mn)/m3) from ACGIH (TLV) [United States] Inhalation Respirable.TWA: 5 (mg(Mn)/m3) [United Kingdom (UK)] Inhalation Total.TWA: 2.5 (mg(Mn)/m3) [Sweden] Inhalation Total.TWA: 1(mg(Mn)/m3) [Sweden] Inhalation Respirable.
Consult local authorities for acceptable exposure limits.
Section 8. Exposure Controls/Personal Protection
Engineering Controls
Personal Protection
Personal Protection in Case ofa Large Spill
Exposure Limits
1190°C (2174°F)
Solid.
Not available.
Not available.
58°C (136.4°F)
2.01 (Water = 1)
Not available.
Not applicable.
Not available.
Not available.
See solubility in water.
Easily soluble in cold water.
Not available.
Not available.
197.9 g/mole
Not available.
Not available.
Not available.
Section 9. Physical and Chemical Properties
Physical state and appearance Odor
Taste
Color
Molecular Weight
pH (1% soln/water)
Boiling Point
Melting Point
Critical Temperature
Specific Gravity
Vapor Pressure
Vapor Density
Volatility
Odor Threshold
Water/Oil Dist. Coeff.
Ionicity (in Water)
Dispersion Properties
Solubility
The product is stable.
Non-corrosive in presence of glass.
Reactive with metals.
Not available.
Excess heat, incompatible materials
Section 10. Stability and Reactivity Data
Stability
Instability Temperature
Conditions of Instability
Incompatibility with varioussubstances
Corrosivity
Continued on Next Page
Manganese chloride tetrahydrate Page Number: 4
Not available.
Hygroscopic; keep container tightly closed.Incompatible with Zinc, potassium, sodium.
Special Remarks onReactivity
Special Remarks onCorrosivity
Polymerization Will not occur.
Inhalation. Ingestion.
Acute oral toxicity (LD50): 1484 mg/kg [Rat].
Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.
May cause damage to the following organs: lungs, central nervous system (CNS).
Not available.
Acute Potential Health Effects:Skin: May cause skin irritation.Eyes: May cause eye irritation.Inhalation: Low hazard. Acute poisoning is rare from acute inhalation. It may cause respiratory tractirritation, and mild to moderate inflammation of the respiratory tract and lung inflammation ("manganesepneumonitis"), bronchitis, exercise-induced dyspnea.Ingestion: May be harmful if swallowed. Acute poisoning is rare, but may occur. It may cause abdominalpain, nausea. It may also affect behavior/central nervous system/nervous system (nervousness, irritability,emotional lability, compulsive behavior, apathy, generalized muscle weakness, a low monotonous voice,muscle twitching, limb stiffness, speech impairment, insomnia, incoordinatioin, difficulty with fine movements,back pain, headache, clumsiness, personality changes, inappropriate crying, laughing and restlessness; gaitalteration, loss of balance, fine tremor, loss of facial expressions, and speech disturbances develops prior tothe onset of "parkinsonism", with muscle regidity, staggering gait, dysphagia, and a course intention tremorapperaring. May also cause sweating, salivation, diminished libido or impotence.Chronic Potential Health Effects:Ingestion or inhalation: It can affect behavior/central nervous system with symptoms similar to that of acuteingestion or inhalation. The primary clinical pattern following chronic exposure involves Parkinson-likesymptoms due to central nervous system effects. The neurologic disorder that develops is known as"manganism." Apsychiatric syndrom, once referred to as "manganese madness", may develop withsymptoms of compulsive behavior, emotional lability and hallucinations. Chronic exposure may also result insignificant decrease in heart rate, excessive salivation, increased sweating, pancreatitis, hypoglycemia,abdominal pain, hypermylasemia, and may affect metabolism (weight loss, hypercalcemia or hypocalcemia,liver, blood, kidneys, brain.
May cause adverse reproductive effects and birth defects (teratogenic) based on animal test data. May cause cancer based on animal test data May affect genetic material (mutagenic)
Section 11. Toxicological Information
Routes of Entry
Toxicity to Animals
Chronic Effects on Humans
Other Toxic Effects onHumans
Special Remarks onToxicity to Animals
Special Remarks onChronic Effects on Humans
Special Remarks on otherToxic Effects on Humans
Not available.
Not available.
Possibly hazardous short term degradation products are not likely. However, long term degradation productsmay arise.
The products of degradation are less toxic than the product itself.
Not available.
Section 12. Ecological Information
Ecotoxicity
BOD5 and COD
Products of Biodegradation
Toxicity of the Productsof Biodegradation
Special Remarks on theProducts of Biodegradation
Continued on Next Page
Manganese chloride tetrahydrate Page Number: 5
Section 13. Disposal Considerations
Waste Disposal Waste must be disposed of in accordance with federal, state and local environmentalcontrol regulations.
DOT Classification Not a DOT controlled material (United States).
Not applicable.
Not applicable.
Section 14. Transport Information
Identification
DOT (Pictograms)
Special Provisions forTransport
EINECS: This product is not listed on the European Inventory of Existing Commercial Chemical Substances.Canada: Not listed on Canadian Domestic Substance List (DSL).China: Listed on National Inventory.Japan: Listed on National Inventory (ENCS).Korea: Not listed on National Inventory (KECI).Philippines: Listed on National Inventory (PICCS).Australia: Listed on AICS.
00
1
1
0
0
E
Not controlled under WHMIS (Canada).
R22- Harmful if swallowed.
Section 15. Other Regulatory Information and Pictograms
Other Regulations
Other Classifications WHMIS (Canada)
DSCL (EEC)
HMIS (U.S.A.) Health Hazard
Fire Hazard
Reactivity
National Fire ProtectionAssociation (U.S.A.)
Personal Protection
Health
Flammability
Reactivity
Specific hazard
WHMIS (Canada)(Pictograms)
DSCL (Europe)(Pictograms)
Federal and StateRegulations
SARA 313 toxic chemical notification and release reporting: Manganese chloride tetrahydrate (listed asManganese compounds).FDA: Everything Added To Food in the United Stated (EAFUS) list
CaliforniaProposition 65Warnings
California prop. 65: This product contains the following ingredients for which the State of California hasfound to cause cancer which would require a warning under the statute: No products were found.
California prop. 65: This product contains the following ingredients for which the State of California hasfound to cause birth defects which would require a warning under the statute: No products were found.
S46- If swallowed, seek medical adviceimmediately and show this container or label.
Continued on Next Page
Manganese chloride tetrahydrate Page Number: 6
TDG (Canada)(Pictograms)
ADR (Europe)(Pictograms)
Protective Equipment
Dust respirator. Be sure to use anapproved/certified respirator orequivalent.
Lab coat.
Safety glasses.
Gloves.
Not available.
Not available.
CALL (310) 516-8000
All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product iscombined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the user's responsibility to develop propermethods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical data judged to be reliable, Spectrum Quality Products,Inc. assumes no responsibility for the completeness or accuracy of the information contained herein.
Notice to Reader
Verified by Sonia Owen.
Printed 2/1/2012.
Validated by Sonia Owen on 2/1/2012.
Other SpecialConsiderations
References
Section 16. Other Information
MSDS Code M3350
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Revision Date 26.01.2018 Version 1.4
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 17
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 102790
Product name Copper(II) sulfate pentahydrate for analysis EMSURE®
ACS,ISO,Reag. Ph Eur
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.
CAS-No. 7758-99-8
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses
Reagent for analysis
For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * 8th Floor, Godrej One,
Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079
India * Tel: 0091 22 6210 9000
Responsible Department Quality Assurance * Merck Life Science Private Limited *
e-mail: [email protected] *
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102790
Product name Copper(II) sulfate pentahydrate for analysis EMSURE® ACS,ISO,Reag. Ph
Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 17
Tel : +91-2267863131-6
1.4 Emergency telephone
number
Please contact the regional company representation in your country.
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
Classification (REGULATION (EC) No 1272/2008)
Acute toxicity, Category 4, Oral, H302
Serious eye damage, Category 1, H318
Acute aquatic toxicity, Category 1, H400
Chronic aquatic toxicity, Category 1, H410
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Hazard pictograms
Signal word
Danger
Hazard statements
H302 Harmful if swallowed.
H318 Causes serious eye damage.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statements
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102790
Product name Copper(II) sulfate pentahydrate for analysis EMSURE® ACS,ISO,Reag. Ph
Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 17
Prevention
P273 Avoid release to the environment.
P280 Wear eye protection.
Response
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
P313 Get medical advice/ attention.
Reduced labelling (≤125 ml)
Hazard pictograms
Signal word
Danger
Hazard statements
H318 Causes serious eye damage.
Precautionary statements
P280 Wear eye protection.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing.
P313 Get medical advice/ attention.
Contains: Copper(II) sulphate pentahydrate
CAS-No. 7758-99-8
2.3 Other hazards
None known.
SECTION 3. Composition/information on ingredients
3.1 Substance
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102790
Product name Copper(II) sulfate pentahydrate for analysis EMSURE® ACS,ISO,Reag. Ph
Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 4 of 17
Formula CuSO₄ * 5 H₂O CuO₄S * 5 H₂O (Hill)
EC-No. 231-847-6
Molar mass 249.68 g/mol
Hazardous components (REGULATION (EC) No 1272/2008)
Chemical name (Concentration)
CAS-No. Registration number Classification
Copper(II) sulphate pentahydrate (>= 80 % - <= 100 % )
7758-99-8 *)
Acute toxicity, Category 4, H302
Serious eye damage, Category 1, H318
Acute aquatic toxicity, Category 1, H400
Chronic aquatic toxicity, Category 1, H410
M-Factor: 10
*) A registration number is not available for this substance as the substance or its use are exempted from registration according to Article
2 REACH Regulation (EC) No 1907/2006, the annual tonnage does not require a registration or the registration is envisaged for a later
registration deadline.
For the full text of the H-Statements mentioned in this Section, see Section 16.
3.2 Mixture
Not applicable
SECTION 4. First aid measures
4.1 Description of first aid measures
After inhalation: fresh air.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower.
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.
After swallowing: immediately make victim drink water (two glasses at most). Consult a
physician.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102790
Product name Copper(II) sulfate pentahydrate for analysis EMSURE® ACS,ISO,Reag. Ph
Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 5 of 17
4.2 Most important symptoms and effects, both acute and delayed
irritant effects, conjunctivitis, gastric pain, Diarrhoea, Vomiting, collapse, death
Risk of corneal clouding.
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SECTION 5. Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Use extinguishing measures that are appropriate to local circumstances and the surrounding
environment.
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Not combustible.
Ambient fire may liberate hazardous vapours.
Fire may cause evolution of:
Sulphur oxides
5.3 Advice for firefighters
Special protective equipment for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.
Further information
Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing
water from contaminating surface water or the ground water system.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102790
Product name Copper(II) sulfate pentahydrate for analysis EMSURE® ACS,ISO,Reag. Ph
Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 6 of 17
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact. Ensure
adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an
expert.
Advice for emergency responders:
Protective equipment see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see
sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation
of dusts.
6.4 Reference to other sections
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handling
Observe label precautions.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and
face after working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102790
Product name Copper(II) sulfate pentahydrate for analysis EMSURE® ACS,ISO,Reag. Ph
Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 7 of 17
Tightly closed. Dry.
Recommended storage temperature see product label.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
Contains no substances with occupational exposure limit values.
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Eye/face protection
Safety glasses
Hand protection
full contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
splash contact:
Glove material: Nitrile rubber
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102790
Product name Copper(II) sulfate pentahydrate for analysis EMSURE® ACS,ISO,Reag. Ph
Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 8 of 17
Glove thickness: 0.11 mm
Break through time: > 480 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 741 Dermatril® L (full contact),
KCL 741 Dermatril® L (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Other protective equipment
protective clothing
Respiratory protection
required when dusts are generated.
Recommended Filter type: Filter P 2 (acc. to DIN 3181) for solid and liquid particles of harmful
substances
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
Environmental exposure controls
Do not let product enter drains.
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
Form solid
Colour blue
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102790
Product name Copper(II) sulfate pentahydrate for analysis EMSURE® ACS,ISO,Reag. Ph
Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 9 of 17
Odour odourless
Odour Threshold Not applicable
pH 3.5 - 4.5
at 50 g/l
20 °C
Melting point 147 °C
Boiling point No information available.
Flash point Not applicable
Evaporation rate No information available.
Flammability (solid, gas) The product is not flammable.
Lower explosion limit Not applicable
Upper explosion limit Not applicable
Vapour pressure No information available.
Relative vapour density No information available.
Density 2.284 g/cm3
at 20 °C
Relative density No information available.
Water solubility 317 g/l
at 20 °C
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102790
Product name Copper(II) sulfate pentahydrate for analysis EMSURE® ACS,ISO,Reag. Ph
Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 10 of 17
Partition coefficient: n-
octanol/water
No information available.
Auto-ignition temperature No information available.
Decomposition temperature No information available.
Viscosity, dynamic No information available.
Explosive properties Not classified as explosive.
Oxidizing properties none
9.2 Other data
Ignition temperature Not applicable
SECTION 10. Stability and reactivity
10.1 Reactivity
See section 10.3
10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.3 Possibility of hazardous reactions
Exothermic reaction with:
Strong oxidizing agents, hydroxylamine, magnesium
10.4 Conditions to avoid
Strong heating (decomposition).
10.5 Incompatible materials
no information available
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102790
Product name Copper(II) sulfate pentahydrate for analysis EMSURE® ACS,ISO,Reag. Ph
Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 11 of 17
10.6 Hazardous decomposition products
in the event of fire: See section 5.
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Acute oral toxicity
LD50 Rat: 482 mg/kg
OECD Test Guideline 401
Symptoms: gastric pain, Vomiting, Diarrhoea
Acute inhalation toxicity
Symptoms: Possible damages:, mucosal irritations
Acute dermal toxicity
LD50 Rat: > 2,000 mg/kg
OECD Test Guideline 402
Skin irritation
Rabbit
Result: No skin irritation
OECD Test Guideline 404
Eye irritation
Rabbit
Result: Causes serious eye damage.
OECD Test Guideline 405
Causes serious eye damage.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102790
Product name Copper(II) sulfate pentahydrate for analysis EMSURE® ACS,ISO,Reag. Ph
Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 12 of 17
Sensitisation
Maximisation Test Guinea pig
Result: negative
Method: OECD Test Guideline 406
Germ cell mutagenicity
Genotoxicity in vivo
Micronucleus test
Mouse
male and female
Oral
Bone marrow
Result: negative
(ECHA)
unscheduled DNA synthesis assay
Rat
male
Oral
Liver cells
Result: negative
Method: OECD Test Guideline 486
Genotoxicity in vitro
Ames test
Salmonella typhimurium
Result: negative
Method: OECD Test Guideline 471
Carcinogenicity
This information is not available.
Reproductive toxicity
This information is not available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102790
Product name Copper(II) sulfate pentahydrate for analysis EMSURE® ACS,ISO,Reag. Ph
Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 13 of 17
Teratogenicity
This information is not available.
Specific target organ toxicity - single exposure
This information is not available.
Specific target organ toxicity - repeated exposure
This information is not available.
Aspiration hazard
This information is not available.
11.2 Further information
After absorption:
drop in blood pressure, tachycardia, collapse, acidosis
After a latency period:
death
Metal-fume fever after inhalation of large quantities.
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
SECTION 12. Ecological information
12.1 Toxicity
No information available.
12.2 Persistence and degradability
Biodegradability
Not applicable for inorganic substances
12.3 Bioaccumulative potential
No information available.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102790
Product name Copper(II) sulfate pentahydrate for analysis EMSURE® ACS,ISO,Reag. Ph
Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 14 of 17
12.6 Other adverse effects
Additional ecological information
Fungicide
Discharge into the environment must be avoided.
SECTION 13. Disposal considerations
Waste treatment methods
Waste material must be disposed of in accordance with the national and local regulations. Leave
chemicals in original containers. No mixing with other waste. Handle uncleaned containers like
the product itself.
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 UN number UN 3077
14.2 Proper shipping name ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID,
N.O.S. (COPPER(II)-SULPHATE)
14.3 Class 9
14.4 Packing group III
14.5 Environmentally hazardous yes
14.6 Special precautions for
user
yes
Tunnel restriction code -
Packages smaller than or equal to 5 kg / L , not dangerous goods of Class 9
Inland waterway transport (ADN)
Not relevant
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102790
Product name Copper(II) sulfate pentahydrate for analysis EMSURE® ACS,ISO,Reag. Ph
Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 15 of 17
Air transport (IATA)
14.1 UN number UN 3077
14.2 Proper shipping name ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID,
N.O.S. (COPPER(II)-SULPHATE)
14.3 Class 9
14.4 Packing group III
14.5 Environmentally hazardous yes
14.6 Special precautions for
user
no
Packages smaller than or equal to 5 kg / L , not dangerous goods of Class 9
Sea transport (IMDG)
14.1 UN number UN 3077
14.2 Proper shipping name ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID,
N.O.S. (COPPER(II)-SULPHATE)
14.3 Class 9
14.4 Packing group III
14.5 Environmentally hazardous yes
14.6 Special precautions for
user
yes
EmS F-A S-F
Segregation Group 0007 Heavy Metals and their salts (incl. their organometallic
compounds)
Packages smaller than or equal to 5 kg / L , not dangerous goods of Class 9
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102790
Product name Copper(II) sulfate pentahydrate for analysis EMSURE® ACS,ISO,Reag. Ph
Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 16 of 17
National legislation
Storage class 10 - 13
15.2 Chemical safety assessment
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Full text of H-Statements referred to under sections 2 and 3.
H302 Harmful if swallowed.
H318 Causes serious eye damage.
H400 Very toxic to aquatic life.
H410 Very toxic to aquatic life with long lasting effects.
Training advice
Provide adequate information, instruction and training for operators.
Labelling
Hazard pictograms
Signal word
Danger
Hazard statements
H302 Harmful if swallowed.
H318 Causes serious eye damage.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statements
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102790
Product name Copper(II) sulfate pentahydrate for analysis EMSURE® ACS,ISO,Reag. Ph
Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 17 of 17
Prevention
P273 Avoid release to the environment.
P280 Wear eye protection.
Response
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
P313 Get medical advice/ attention.
Contains: Copper(II) sulphate pentahydrate
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
p. 1
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Material Safety Data SheetBoric acid MSDS
Section 1: Chemical Product and Company Identification
Product Name: Boric acid
Catalog Codes: SLB2533, SLB4513
CAS#: 10043-35-3
RTECS: ED4550000
TSCA: TSCA 8(b) inventory: Boric acid
CI#: Not available.
Synonym:
Chemical Name: Boric Acid
Chemical Formula: H3BO3
Contact Information:
Sciencelab.com, Inc.14025 Smith Rd.Houston, Texas 77396
US Sales: 1-800-901-7247International Sales: 1-281-441-4400
Order Online: ScienceLab.com
CHEMTREC (24HR Emergency Telephone), call:1-800-424-9300
International CHEMTREC, call: 1-703-527-3887
For non-emergency assistance, call: 1-281-441-4400
Section 2: Composition and Information on Ingredients
Composition:
Name CAS # % by Weight
Boric acid 10043-35-3 100
Toxicological Data on Ingredients: Boric acid: ORAL (LD50): Acute: 2660 mg/kg [Rat]. 3450 mg/kg [Mouse].
Section 3: Hazards Identification
Potential Acute Health Effects:Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Slightly hazardous in case ofskin contact (permeator).
Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast. TERATOGENICEFFECTS: Not available. DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Reproductive system/toxin/male [POSSIBLE]. The substance may be toxic to kidneys, cardiovascular system, central nervous system (CNS).Repeated or prolonged exposure to the substance can produce target organs damage.
Section 4: First Aid Measures
Eye Contact:
p. 2
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15minutes. Cold water may be used. Get medical attention.
Skin Contact:In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminatedclothing and shoes. Cold water may be used.Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medicalattention.
Serious Skin Contact:Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention.
Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention.
Serious Inhalation: Not available.
Ingestion:Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconsciousperson. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.
Serious Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: Non-flammable.
Auto-Ignition Temperature: Not applicable.
Flash Points: Not applicable.
Flammable Limits: Not applicable.
Products of Combustion: Not available.
Fire Hazards in Presence of Various Substances: Not applicable.
Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product inpresence of static discharge: Not available.
Fire Fighting Media and Instructions: Not applicable.
Special Remarks on Fire Hazards: Not available.
Special Remarks on Explosion Hazards:A mixture of potassium and boric acid may explode on impact. A mixture of boric acid and acetic anydride will explode whenheated to 58-60 C
Section 6: Accidental Release Measures
Small Spill:Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water onthe contaminated surface and dispose of according to local and regional authority requirements.
Large Spill:Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on thecontaminated surface and allow to evacuate through the sanitary system.
Section 7: Handling and Storage
Precautions:
p. 3
Keep locked up.. Do not ingest. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation,wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoidcontact with skin and eyes. Keep away from incompatibles such as alkalis.
Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 23°C (73.4°F).
Section 8: Exposure Controls/Personal Protection
Engineering Controls:Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommendedexposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminantsbelow the exposure limit.
Personal Protection:Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.
Exposure Limits: Not available.
Section 9: Physical and Chemical Properties
Physical state and appearance: Solid. (Powdered solid.)
Odor: Odorless.
Taste: Bitter. (Slight.)
Molecular Weight: 61.83 g/mole
Color: White.
pH (1% soln/water): 5.2 [Acidic.]
Boiling Point: 300°C (572°F)
Melting Point: 169°C (336.2°F)
Critical Temperature: Not available.
Specific Gravity: 1.435 (Water = 1)
Vapor Pressure: Not applicable.
Vapor Density: Not available.
Volatility: Not available.
Odor Threshold: Not available.
Water/Oil Dist. Coeff.: Not available.
Ionicity (in Water): Not available.
Dispersion Properties: See solubility in water, methanol.
Solubility:Soluble in hot water, methanol. Partially soluble in cold water. Very slightly soluble in acetone.
Section 10: Stability and Reactivity Data
p. 4
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: High temperatures, dust generation, incompatible materials.
Incompatibility with various substances: Reactive with alkalis.
Corrosivity: Not available.
Special Remarks on Reactivity: Incompatible with Potassium , Acetic Anhydride. Reacts with basic materials to form boratesalts.
Special Remarks on Corrosivity: Not available.
Polymerization: Will not occur.
Section 11: Toxicological Information
Routes of Entry: Absorbed through skin. Inhalation. Ingestion.
Toxicity to Animals: Acute oral toxicity (LD50): 2660 mg/kg [Rat].
Chronic Effects on Humans:MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast. DEVELOPMENTAL TOXICITY: Classified Reproductivesystem/toxin/female, Reproductive system/toxin/male [POSSIBLE]. May cause damage to the following organs: kidneys,cardiovascular system, central nervous system (CNS).
Other Toxic Effects on Humans:Hazardous in case of skin contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact (permeator).
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans:May cause adverse reproductive effects (fertility, fetoxicity) based on animal studies. May affect genetic material. May causeteratogenic effects based on animal studies.
Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: May cause skin irritation. May be absorbed throuogh damaged or abraded skin inharmful amounts. If absorbed through skin it may affect behavior, sense organs, metabolism, the gastrointestinal tract,and the respiratory tract (respiratory depression) Eyes: Dust causes eye irritation. Inhalation: Dust causes respiratory tractirritation. Ingestion: Causes digestive (gastrointestinal) tract irritation with nausea, vomiting and diarrhea. May also affectbehavior, brain, the Central Nervous System (depression, headache, dizziness, drowsiness, collapse, unconsciousness,coma), Peripheral Nervous System, cardiovascular system, blood, liver, urinary system (kidney, ureter, bladder) and endocrinesystem . Chronic Potential Health Effects: Boric acid can accumlate in the body (brain, bone) with repeated exposure.Prolonged or repeated skin contact may cause dermatitis. May cause borism characterized by dry skin, skin eruptions, andgastric disturbances.
Section 12: Ecological Information
Ecotoxicity: Not available.
BOD5 and COD: Not available.
Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
p. 5
Waste Disposal:
Section 14: Transport Information
DOT Classification: Not a DOT controlled material (United States).
Identification: Not applicable.
Special Provisions for Transport: Not applicable.
Section 15: Other Regulatory Information
Federal and State Regulations: TSCA 8(b) inventory: Boric acid
Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
Other Classifications:
WHMIS (Canada): CLASS D-2A: Material causing other toxic effects (VERY TOXIC).
DSCL (EEC):R36/38- Irritating to eyes and skin. R40- Possible risks of irreversible effects. R62- Possible risk of impaired fertility. S24/25-Avoid contact with skin and eyes.
HMIS (U.S.A.):
Health Hazard: 2
Fire Hazard: 0
Reactivity: 0
Personal Protection: E
National Fire Protection Association (U.S.A.):
Health: 1
Flammability: 0
Reactivity: 0
Specific hazard:
Protective Equipment:Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Splash goggles.
Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.
Created: 10/10/2005 08:15 PM
Last Updated: 05/21/2013 12:00 PM
The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or for
p. 6
lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Revision Date 08.08.2017 Version 1.1
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 13
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 106521
Product name Sodium molybdate dihydrate for analysis EMSURE®
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.
CAS-No. 10102-40-6
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Reagent for analysis
For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * 8th Floor, Godrej One,
Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079
India * Tel: 0091 22 6210 9000
Responsible Department Quality Assurance * Merck Life Science Private Limited *
e-mail: [email protected] *
Tel : +91-2267863131-6
1.4 Emergency telephone
number
Please contact the regional company representation in your country.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106521
Product name Sodium molybdate dihydrate for analysis EMSURE®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 13
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
This substance is not classified as dangerous according to European Union legislation.
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
2.3 Other hazards
None known.
SECTION 3. Composition/information on ingredients
3.1 Substance
Formula Na₂MoO₄ * 2 H₂O Na₂MoO₄ * 2 H₂O (Hill)
EC-No. 231-551-7
Molar mass 241.95 g/mol
Remarks No disclosure requirement according to Regulation (EC) No.
1907/2006.
3.2 Mixture
Not applicable
SECTION 4. First aid measures
4.1 Description of first aid measures
After inhalation: fresh air.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106521
Product name Sodium molybdate dihydrate for analysis EMSURE®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 13
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower.
After eye contact: rinse out with plenty of water. Remove contact lenses.
After swallowing: make victim drink water (two glasses at most). Consult doctor if feeling unwell.
4.2 Most important symptoms and effects, both acute and delayed
Nausea, Vomiting
Symptoms of an acute molybdenum(VI) intoxication: diarrhoea, anaemia (decreased
haemoglobin concentration in the blood), fatigue. Toxic effect on liver and kidneys after high
doses.
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SECTION 5. Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Use extinguishing measures that are appropriate to local circumstances and the surrounding
environment.
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Not combustible.
Ambient fire may liberate hazardous vapours.
5.3 Advice for firefighters
Special protective equipment for firefighters
In the event of fire, wear self-contained breathing apparatus.
Further information
Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing
water from contaminating surface water or the ground water system.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106521
Product name Sodium molybdate dihydrate for analysis EMSURE®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 4 of 13
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid inhalation of dusts. Evacuate the danger area,
observe emergency procedures, consult an expert.
Advice for emergency responders:
Protective equipment see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see
sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation
of dusts.
6.4 Reference to other sections
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handling
Observe label precautions.
Hygiene measures
Change contaminated clothing. Wash hands after working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed. Dry.
Recommended storage temperature see product label.
7.3 Specific end use(s)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106521
Product name Sodium molybdate dihydrate for analysis EMSURE®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 5 of 13
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
Contains no substances with occupational exposure limit values.
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Eye/face protection
Safety glasses
Hand protection
full contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
splash contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 741 Dermatril® L (full contact),
KCL 741 Dermatril® L (splash contact).
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106521
Product name Sodium molybdate dihydrate for analysis EMSURE®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 6 of 13
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Respiratory protection
required when dusts are generated.
Recommended Filter type: Filter P 1 (acc. to DIN 3181) for solid particles of inert substances
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
Environmental exposure controls
Do not let product enter drains.
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
Form crystals
Colour white
Odour odourless
Odour Threshold Not applicable
pH 9 - 10
at 840 g/l
20 °C
Melting point 687 °C
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106521
Product name Sodium molybdate dihydrate for analysis EMSURE®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 7 of 13
Boiling point/boiling range Not applicable
Flash point Not applicable
Evaporation rate No information available.
Flammability (solid, gas) The product is not flammable.
Lower explosion limit Not applicable
Upper explosion limit Not applicable
Vapour pressure Not applicable
Relative vapour density No information available.
Density 2.71 g/cm3
at 22 °C
Relative density No information available.
Water solubility 840 g/l
at 20 °C
Partition coefficient: n-
octanol/water
Not applicable
Auto-ignition temperature No information available.
Decomposition temperature 130 °C
Elimination of water of crystallisation
Viscosity, dynamic No information available.
Explosive properties Not classified as explosive.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106521
Product name Sodium molybdate dihydrate for analysis EMSURE®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 8 of 13
Oxidizing properties none
9.2 Other data
Bulk density 1,000 - 1,400 kg/m3
SECTION 10. Stability and reactivity
10.1 Reactivity
See section 10.3
10.2 Chemical stability
releases water of crystallisation when heated.
10.3 Possibility of hazardous reactions
no information available
10.4 Conditions to avoid
Strong heating (decomposition).
10.5 Incompatible materials
no information available
10.6 Hazardous decomposition products
in the event of fire: See section 5.
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Acute oral toxicity
LD50 Rat: 4,233 mg/kg
(External MSDS)
Symptoms: Nausea, Vomiting
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106521
Product name Sodium molybdate dihydrate for analysis EMSURE®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 9 of 13
Acute inhalation toxicity
This information is not available.
Acute dermal toxicity
LD50 Rat: > 2,000 mg/kg
(External MSDS)
Skin irritation
Rabbit
Result: No irritation
(External MSDS)
Eye irritation
Rabbit
Result: slight irritation
(External MSDS)
Sensitisation
Sensitisation test: Guinea pig
Result: negative
Method: OECD Test Guideline 406
Germ cell mutagenicity
Genotoxicity in vivo
Mutagenicity (mammal cell test): micronucleus.
Result: positive
(Lit.)
Genotoxicity in vitro
Mutagenicity (mammal cell test):
Result: positive
(Lit.)
Carcinogenicity
This information is not available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106521
Product name Sodium molybdate dihydrate for analysis EMSURE®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 10 of 13
Reproductive toxicity
This information is not available.
Teratogenicity
This information is not available.
Specific target organ toxicity - single exposure
This information is not available.
Specific target organ toxicity - repeated exposure
This information is not available.
Aspiration hazard
This information is not available.
11.2 Further information
Symptoms of an acute molybdenum(VI) intoxication: diarrhoea, anaemia (decreased
haemoglobin concentration in the blood), fatigue. Toxic effect on liver and kidneys after high
doses.
However, when the product is handled appropriately, hazardous effects are unlikely to occur.
Handle in accordance with good industrial hygiene and safety practice.
SECTION 12. Ecological information
12.1 Toxicity
Toxicity to fish
NOEC Oncorhynchus mykiss (rainbow trout): 3,200 mg/l; 96 h
(External MSDS)
LC50 Oncorhynchus mykiss (rainbow trout): 7,600 mg/l; 96 h
(External MSDS)
Toxicity to daphnia and other aquatic invertebrates
NOEC Daphnia magna (Water flea): 100 mg/l; 48 h
(External MSDS)
EC50 Daphnia magna (Water flea): 330 mg/l; 48 h
(External MSDS)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106521
Product name Sodium molybdate dihydrate for analysis EMSURE®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 11 of 13
Toxicity to algae
NOEC Pseudokirchneriella subcapitata (green algae): 4.6 mg/l; 72 h
(External MSDS)
IC50 Pseudokirchneriella subcapitata (green algae): > 100 mg/l; 72 h
(External MSDS)
Toxicity to bacteria
EC10 Pseudomonas putida: 50 mg/l; 18 h
(External MSDS)
12.2 Persistence and degradability
No information available.
12.3 Bioaccumulative potential
Partition coefficient: n-octanol/water
Not applicable
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.
12.6 Other adverse effects
Discharge into the environment must be avoided.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106521
Product name Sodium molybdate dihydrate for analysis EMSURE®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 12 of 13
SECTION 13. Disposal considerations
Waste treatment methods
Waste material must be disposed of in accordance with the national and local regulations. Leave
chemicals in original containers. No mixing with other waste. Handle uncleaned containers like
the product itself.
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Sea transport (IMDG)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National legislation
Storage class 10 - 13
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106521
Product name Sodium molybdate dihydrate for analysis EMSURE®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 13 of 13
15.2 Chemical safety assessment
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Training advice
Provide adequate information, instruction and training for operators.
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
MATERIAL SAFETY DATA SHEETMATERIAL SAFETY DATA SHEETMATERIAL SAFETY DATA SHEETMATERIAL SAFETY DATA SHEET
1111. . . . Product and Company IdentificationProduct and Company IdentificationProduct and Company IdentificationProduct and Company IdentificationMaterial nameMaterial nameMaterial nameMaterial name ZINC SULFATE HEPTAHYDRATEZINC SULFATE HEPTAHYDRATEZINC SULFATE HEPTAHYDRATEZINC SULFATE HEPTAHYDRATEVersion #Version #Version #Version # 02Revision dateRevision dateRevision dateRevision date 08-30-2011CAS #CAS #CAS #CAS # 7446-20-0Product CodesProduct CodesProduct CodesProduct Codes J.T.Baker: 4382, 4383, 4384J.T.Baker: 4382, 4383, 4384J.T.Baker: 4382, 4383, 4384J.T.Baker: 4382, 4383, 4384
Macron: 8872, 8880Macron: 8872, 8880Macron: 8872, 8880Macron: 8872, 8880Synonym(s)Synonym(s)Synonym(s)Synonym(s) Sulfuric acid, zinc salt (1:1), heptahydrate
Customer ServiceCustomer ServiceCustomer ServiceCustomer Service 855-282-686724 Hour Emergency24 Hour Emergency24 Hour Emergency24 Hour Emergency 908-859-2151ChemtrecChemtrecChemtrecChemtrec 800-424-9300
ManufacturerManufacturerManufacturerManufacturerAddressAddressAddressAddress
Avantor Performance Materials, Inc.3477 Corporate Parkway
Center Valley, PA 18034US
Suite #200
2222. . . . Hazards IdentificationHazards IdentificationHazards IdentificationHazards IdentificationEmergency overviewEmergency overviewEmergency overviewEmergency overview DANGER
Harmful if inhaled or swallowed. Causes eye burns. Causes skin irritation. Dust or vapor irritatingto the eyes and respiratory tract.
OSHA regulatory statusOSHA regulatory statusOSHA regulatory statusOSHA regulatory status This product is considered hazardous under 29 CFR 1910.1200 (Hazard Communication).
Potential health effectsPotential health effectsPotential health effectsPotential health effectsRoutes of exposureRoutes of exposureRoutes of exposureRoutes of exposure Ingestion. Inhalation. Skin contact. Eye contact.EyesEyesEyesEyes Causes eye burns. Dust or splashes from the mixture may cause permanent eye damage.SkinSkinSkinSkin Causes skin irritation. Prolonged or repeated contact with skin may cause redness, itching,
irritation and eczema/chapping.InhalationInhalationInhalationInhalation Harmful if inhaled. Dust may irritate throat and respiratory system and cause coughing.IngestionIngestionIngestionIngestion Harmful if swallowed. Ingestion may cause gastrointestinal irritation, nausea, vomiting and
diarrhea.Target organsTarget organsTarget organsTarget organs Eyes. Skin. Respiratory system. Liver. Kidney.Chronic effectsChronic effectsChronic effectsChronic effects Prolonged or repeated exposure may cause liver and kidney damage. These effects have not
been observed in humans.
Potential environmental effectsPotential environmental effectsPotential environmental effectsPotential environmental effects Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
ComponentsComponentsComponentsComponents CAS #CAS #CAS #CAS # PercentPercentPercentPercent
3333. . . . Composition Composition Composition Composition / / / / Information on IngredientsInformation on IngredientsInformation on IngredientsInformation on Ingredients
7446-20-0 100ZINC SULFATE HEPTAHYDRATE
Composition commentsComposition commentsComposition commentsComposition comments CAS # 7446-20-0 can be described by the CAS # 7733-02-0.
4444. . . . First Aid MeasuresFirst Aid MeasuresFirst Aid MeasuresFirst Aid MeasuresFirst aid proceduresFirst aid proceduresFirst aid proceduresFirst aid procedures
Eye contactEye contactEye contactEye contact Immediately flush with plenty of water for at least 15 minutes. If easy to do, remove contactlenses. Get medical attention. In case of irritation from airborne exposure, move to fresh air. Getmedical attention if irritation develops and persists.
Material name: ZINC SULFATE HEPTAHYDRATEMSDS ID: Z4560 Version #: 02 Revision date: 08-30-2011
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Skin contactSkin contactSkin contactSkin contact Immediately flush with plenty of water for at least 15 minutes while removing contaminatedclothing and shoes. Get medical attention. Wash clothing separately before reuse. Destroy orthoroughly clean contaminated shoes.
InhalationInhalationInhalationInhalation Move to fresh air. If breathing stops, provide artificial respiration. If breathing is difficult, giveoxygen. Get medical attention.
IngestionIngestionIngestionIngestion Call a physician or poison control center immediately. Only induce vomiting at the instruction ofmedical personnel. Never give anything by mouth to an unconscious person. If vomiting occurs,keep head low so that stomach content doesn't get into the lungs.
Notes to physicianNotes to physicianNotes to physicianNotes to physician Keep victim under observation. Treat symptomatically.General adviceGeneral adviceGeneral adviceGeneral advice In the case of accident or if you feel unwell, seek medical advice immediately (show the label
where possible). Show this safety data sheet to the doctor in attendance. Ensure that medicalpersonnel are aware of the material(s) involved, and take precautions to protect themselves.
5555. . . . Fire Fighting MeasuresFire Fighting MeasuresFire Fighting MeasuresFire Fighting MeasuresFlammable propertiesFlammable propertiesFlammable propertiesFlammable properties The product is not flammable. No unusual fire or explosion hazards noted.
Extinguishing mediaExtinguishing mediaExtinguishing mediaExtinguishing mediaSuitable extinguishingSuitable extinguishingSuitable extinguishingSuitable extinguishingmediamediamediamedia
Water spray. Carbon dioxide (CO2). Dry chemical powder. Foam.
Unsuitable extinguishingUnsuitable extinguishingUnsuitable extinguishingUnsuitable extinguishingmediamediamediamedia
None known.
Protection of firefightersProtection of firefightersProtection of firefightersProtection of firefightersSpecific hazards arisingSpecific hazards arisingSpecific hazards arisingSpecific hazards arisingfrom the chemicalfrom the chemicalfrom the chemicalfrom the chemical
Fire may produce irritating, corrosive and/or toxic gases.
Protective equipment andProtective equipment andProtective equipment andProtective equipment andprecautions for firefightersprecautions for firefightersprecautions for firefightersprecautions for firefighters
Use water spray to cool unopened containers. Self-contained breathing apparatus and fullprotective clothing must be worn in case of fire. Cool containers exposed to flames with water untilwell after the fire is out.
Special protective equipment forSpecial protective equipment forSpecial protective equipment forSpecial protective equipment forfire-fightersfire-fightersfire-fightersfire-fighters
Wear full protective clothing, including helmet, self-contained positive pressure or pressuredemand breathing apparatus, protective clothing and face mask. Wear self-contained breathingapparatus with a full facepiece operated in the positive pressure demand mode when fightingfires.
Specific methodsSpecific methodsSpecific methodsSpecific methods In the event of fire and/or explosion do not breathe fumes.
6666. . . . Accidental Release MeasuresAccidental Release MeasuresAccidental Release MeasuresAccidental Release MeasuresPersonal precautionsPersonal precautionsPersonal precautionsPersonal precautions Keep unnecessary personnel away. Wear appropriate protective equipment and clothing during
clean-up. Keep upwind. Keep out of low areas. Ventilate closed spaces before entering them.Local authorities should be advised if significant spillages cannot be contained.
Environmental precautionsEnvironmental precautionsEnvironmental precautionsEnvironmental precautions Do not allow to enter drains, sewers or watercourses. Prevent further leakage or spillage if safe todo so.
Methods for containmentMethods for containmentMethods for containmentMethods for containment Prevent entry into waterways, sewers, basements or confined areas. Stop leak if you can do sowithout risk. Dike the spilled material, where this is possible.
Methods for cleaning upMethods for cleaning upMethods for cleaning upMethods for cleaning up Avoid dust formation.
Large Spills: Sweep up or vacuum up spillage and collect in suitable container for disposal.
Small Spills: Sweep up and place in a clearly labeled container for chemical waste. Clean surfacethoroughly to remove residual contamination.
Never return spills in original containers for re-use. Clean up in accordance with all applicableregulations. Collect in a non-combustible container for prompt disposal.
7777. . . . Handling and StorageHandling and StorageHandling and StorageHandling and StorageHandlingHandlingHandlingHandling Wear appropriate personal protective equipment. Avoid breathing dust. Do not get in eyes and
avoid contact with skin and clothing. Do not taste or swallow. Wash thoroughly after handling. Donot eat, drink or smoke when using the product. See Section 8 of the MSDS for PersonalProtective Equipment.
Material name: ZINC SULFATE HEPTAHYDRATEMSDS ID: Z4560 Version #: 02 Revision date: 08-30-2011
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StorageStorageStorageStorage Keep tightly closed in a dry, cool and well-ventilated place.
8888. . . . Exposure Controls Exposure Controls Exposure Controls Exposure Controls / / / / Personal ProtectionPersonal ProtectionPersonal ProtectionPersonal ProtectionEngineering controlsEngineering controlsEngineering controlsEngineering controls Good general ventilation (typically 10 air changes per hour) should be used. Ventilation rates
should be matched to conditions. If applicable, use process enclosures, local exhaust ventilation,or other engineering controls to maintain airborne levels below recommended exposure limits. Ifexposure limits have not been established, maintain airborne levels to an acceptable level.
Personal protective equipmentPersonal protective equipmentPersonal protective equipmentPersonal protective equipmentEye / face protectionEye / face protectionEye / face protectionEye / face protection Chemical goggles and face shield are recommended.Skin protectionSkin protectionSkin protectionSkin protection Wear appropriate chemical resistant clothing. Wear appropriate chemical resistant gloves.Respiratory protectionRespiratory protectionRespiratory protectionRespiratory protection If engineering controls do not maintain airborne concentrations below recommended exposure
limits (where applicable) or to an acceptable level (in countries where exposure limits have notbeen established), an approved respirator must be worn. Respirator type: High-efficiencyparticulate respirator with full facepiece.
General hygeineGeneral hygeineGeneral hygeineGeneral hygeineconsiderationsconsiderationsconsiderationsconsiderations
Provide eyewash station and safety shower. Always observe good personal hygiene measures,such as washing after handling the material and before eating, drinking, and/or smoking.Routinely wash work clothing and protective equipment to remove contaminants.
GeneralGeneralGeneralGeneral Wear chemical protective equipment that is specifically recommended by the manufacturer.Launder contaminated clothing before reuse.
9999. . . . Physical & Chemical PropertiesPhysical & Chemical PropertiesPhysical & Chemical PropertiesPhysical & Chemical PropertiesAppearanceAppearanceAppearanceAppearance Crystalline. Granular.
ColorColorColorColor Colorless.
OdorOdorOdorOdor Odorless.
Odor thresholdOdor thresholdOdor thresholdOdor threshold Not available.
Physical statePhysical statePhysical statePhysical state Solid.
FormFormFormForm Solid.
pHpHpHpH 4.5 aqueous solution
Melting pointMelting pointMelting pointMelting point 212 °F (100 °C)
Freezing pointFreezing pointFreezing pointFreezing point 212 °F (100 °C)
Boiling pointBoiling pointBoiling pointBoiling point > 932 °F (> 500 °C) Decomposes.
Flash pointFlash pointFlash pointFlash point Not available.
Evaporation rateEvaporation rateEvaporation rateEvaporation rate Not available.
Flammability limits in air, upper,Flammability limits in air, upper,Flammability limits in air, upper,Flammability limits in air, upper,% by volume% by volume% by volume% by volume
Not available.
Flammability limits in air, lower,Flammability limits in air, lower,Flammability limits in air, lower,Flammability limits in air, lower,% by volume% by volume% by volume% by volume
Not available.
Vapor densityVapor densityVapor densityVapor density Not available.
Specific gravitySpecific gravitySpecific gravitySpecific gravity 1.97
Relative densityRelative densityRelative densityRelative density Not available.
Solubility (water)Solubility (water)Solubility (water)Solubility (water) 960 g/l
Partition coefficientPartition coefficientPartition coefficientPartition coefficient(n-octanol/water)(n-octanol/water)(n-octanol/water)(n-octanol/water)
Not available
Auto-ignition temperatureAuto-ignition temperatureAuto-ignition temperatureAuto-ignition temperature Not available.
Molecular weightMolecular weightMolecular weightMolecular weight 287.56 g/mol
Molecular formulaMolecular formulaMolecular formulaMolecular formula O4-S-Zn.7H2O
10101010. . . . Chemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical stabilityChemical stabilityChemical stabilityChemical stability Stable under normal temperature conditions.Conditions to avoidConditions to avoidConditions to avoidConditions to avoid Excessive heat. Water, moisture.
Material name: ZINC SULFATE HEPTAHYDRATEMSDS ID: Z4560 Version #: 02 Revision date: 08-30-2011
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Incompatible materialsIncompatible materialsIncompatible materialsIncompatible materials Strong oxidizing agents. Inorganic salts.Hazardous decompositionHazardous decompositionHazardous decompositionHazardous decompositionproductsproductsproductsproducts
Zinc oxide. Sulfur oxides.
Possibility of hazardousPossibility of hazardousPossibility of hazardousPossibility of hazardousreactionsreactionsreactionsreactions
Hazardous polymerization does not occur.
Toxicological dataToxicological dataToxicological dataToxicological data
11111111. . . . Toxicological InformationToxicological InformationToxicological InformationToxicological Information
ProductProductProductProduct Test ResultsTest ResultsTest ResultsTest ResultsAcute Dermal LD50 Rat: > 2000 mg/kgZINC SULFATE HEPTAHYDRATE (7446-20-0)
Acute Oral LD50 Rat: 623 mg/kg
SensitizationSensitizationSensitizationSensitization Not a skin sensitizer.
Acute effectsAcute effectsAcute effectsAcute effects Harmful if inhaled or swallowed.
Local effectsLocal effectsLocal effectsLocal effects Causes eye burns. Causes skin irritation. Inhalation of dusts may cause respiratory irritation.
Chronic effectsChronic effectsChronic effectsChronic effects Prolonged or repeated exposure may cause liver and kidney damage. These effects have notbeen observed in humans.
CarcinogenicityCarcinogenicityCarcinogenicityCarcinogenicity This product is not considered to be a carcinogen by IARC, ACGIH, NTP, or OSHA.
Skin corrosion/irritationSkin corrosion/irritationSkin corrosion/irritationSkin corrosion/irritation Causes skin irritation.
EpidemiologyEpidemiologyEpidemiologyEpidemiology No epidemiological data is available for this product.
MutagenicityMutagenicityMutagenicityMutagenicity No data available to indicate product or any components present at greater than 0.1% aremutagenic or genotoxic.
Neurological effectsNeurological effectsNeurological effectsNeurological effects No data available for this product.
Reproductive effectsReproductive effectsReproductive effectsReproductive effects Contains no ingredient listed as toxic to reproduction
TeratogenicityTeratogenicityTeratogenicityTeratogenicity No data available to indicate product or any components present at greater than 0.1% may causebirth defects.
Symptoms and targetSymptoms and targetSymptoms and targetSymptoms and targetorgansorgansorgansorgans
Severe eye irritation. Moderate skin irritation. Upper respiratory tract irritation.
Ecotoxicological dataEcotoxicological dataEcotoxicological dataEcotoxicological data
12121212. . . . Ecological InformationEcological InformationEcological InformationEcological Information
ProductProductProductProduct Test ResultsTest ResultsTest ResultsTest Results
EC50 Water flea (Ceriodaphnia dubia): 0.06 mg/l 48.00 hoursZINC SULFATE HEPTAHYDRATE (7446-20-0)LC50 Rainbow trout,donaldson trout (Oncorhynchus mykiss):0.103 mg/l 96.00 hours
EcotoxicityEcotoxicityEcotoxicityEcotoxicity Expected to be very toxic to aquatic organisms. May cause long-term adverse effects in theenvironment. The product may affect the acidity (pH-factor) in water with risk of harmful effects toaquatic organisms.
Persistence andPersistence andPersistence andPersistence anddegradabilitydegradabilitydegradabilitydegradability
The product is not readily biodegradable.
Partition coefficientPartition coefficientPartition coefficientPartition coefficient(n-octanol/water)(n-octanol/water)(n-octanol/water)(n-octanol/water)
Not available
13131313. . . . Disposal ConsiderationsDisposal ConsiderationsDisposal ConsiderationsDisposal ConsiderationsDisposal instructionsDisposal instructionsDisposal instructionsDisposal instructions Dispose of this material and its container to hazardous or special waste collection point.
Incinerate the material under controlled conditions in an approved incinerator. All wastes must behandled in accordance with local, state and federal regulations.
Contaminated packagingContaminated packagingContaminated packagingContaminated packaging Since emptied containers retain product residue, follow label warnings even after container isemptied. Offer rinsed packaging material to local recycling facilities.
Material name: ZINC SULFATE HEPTAHYDRATEMSDS ID: Z4560 Version #: 02 Revision date: 08-30-2011
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14141414. . . . Transport InformationTransport InformationTransport InformationTransport InformationDOTDOTDOTDOTNot regulated as dangerous goods.
IATAIATAIATAIATANot regulated as dangerous goods.
IMDGIMDGIMDGIMDGNot regulated as dangerous goods.
15151515. . . . Regulatory InformationRegulatory InformationRegulatory InformationRegulatory InformationUS federal regulationsUS federal regulationsUS federal regulationsUS federal regulations This product is a "Hazardous Chemical" as defined by the OSHA Hazard Communication
Standard, 29 CFR 1910.1200.
This product is not listed on the U.S. EPA TSCA Inventory. Under TSCA, hydrates areconsidered mixtures of their anhydrous salt and water. Accordingly, the anhydrous form issubject to TSCA reporting requirements.
US EPCRA (SARA Title III) Section 313 - Toxic Chemical: De minimis concentrationUS EPCRA (SARA Title III) Section 313 - Toxic Chemical: De minimis concentrationUS EPCRA (SARA Title III) Section 313 - Toxic Chemical: De minimis concentrationUS EPCRA (SARA Title III) Section 313 - Toxic Chemical: De minimis concentrationZINC SULFATE HEPTAHYDRATE (CAS 7446-20-0) 1.0 % N982
US EPCRA (SARA Title III) Section 313 - Toxic Chemical: Listed substanceUS EPCRA (SARA Title III) Section 313 - Toxic Chemical: Listed substanceUS EPCRA (SARA Title III) Section 313 - Toxic Chemical: Listed substanceUS EPCRA (SARA Title III) Section 313 - Toxic Chemical: Listed substanceZINC SULFATE HEPTAHYDRATE (CAS 7446-20-0) Listed. N982
CERCLA (Superfund) reportable quantityCERCLA (Superfund) reportable quantityCERCLA (Superfund) reportable quantityCERCLA (Superfund) reportable quantityZINC SULFATE HEPTAHYDRATE: 1000.0000
Superfund Amendments and Reauthorization Act of 1986 (SARA)Superfund Amendments and Reauthorization Act of 1986 (SARA)Superfund Amendments and Reauthorization Act of 1986 (SARA)Superfund Amendments and Reauthorization Act of 1986 (SARA)Hazard categoriesHazard categoriesHazard categoriesHazard categories Immediate Hazard - Yes
Delayed Hazard - NoFire Hazard - NoPressure Hazard - NoReactivity Hazard - No
Section 311 hazardousSection 311 hazardousSection 311 hazardousSection 311 hazardouschemicalchemicalchemicalchemical
Yes
Clean Water Act (CWA)Clean Water Act (CWA)Clean Water Act (CWA)Clean Water Act (CWA) Hazardous substancePriority pollutantToxic pollutant
Inventory statusInventory statusInventory statusInventory statusCountryCountryCountryCountry((((ssss) ) ) ) or regionor regionor regionor region Inventory nameInventory nameInventory nameInventory name On inventory On inventory On inventory On inventory ((((yesyesyesyes////nononono)*)*)*)*
YesAustralia Australian Inventory of Chemical Substances (AICS)YesCanada Domestic Substances List (DSL)NoCanada Non-Domestic Substances List (NDSL)
YesChina Inventory of Existing Chemical Substances in China (IECSC)YesEurope European Inventory of Existing Commercial Chemical
Substances (EINECS)NoEurope European List of Notified Chemical Substances (ELINCS)
YesJapan Inventory of Existing and New Chemical Substances (ENCS)NoKorea Existing Chemicals List (ECL)
YesNew Zealand New Zealand InventoryYesPhilippines Philippine Inventory of Chemicals and Chemical Substances
(PICCS)NoUnited States & Puerto Rico Toxic Substances Control Act (TSCA) Inventory
*A "Yes" indicates that all components of this product comply with the inventory requirements administered by the governing country(s)
State regulationsState regulationsState regulationsState regulations This product does not contain a chemical known to the State of California to cause cancer, birthdefects or other reproductive harm.
Material name: ZINC SULFATE HEPTAHYDRATEMSDS ID: Z4560 Version #: 02 Revision date: 08-30-2011
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US - New Jersey Community RTK (EHS Survey): Reportable thresholdUS - New Jersey Community RTK (EHS Survey): Reportable thresholdUS - New Jersey Community RTK (EHS Survey): Reportable thresholdUS - New Jersey Community RTK (EHS Survey): Reportable thresholdZINC SULFATE HEPTAHYDRATE (CAS 7446-20-0) 500 LBS
US - Pennsylvania RTK - Hazardous Substances: Listed substanceUS - Pennsylvania RTK - Hazardous Substances: Listed substanceUS - Pennsylvania RTK - Hazardous Substances: Listed substanceUS - Pennsylvania RTK - Hazardous Substances: Listed substanceZINC SULFATE HEPTAHYDRATE (CAS 7446-20-0) Listed.
Saf-T-DataSaf-T-DataSaf-T-DataSaf-T-Data Health: 1 - SlightFlammability: 0 - NoneReactivity: 1 - SlightContact: 3 - SevereLab Protective Equip: D - GOGGLES & SHIELD; LAB COAT & APRON; VENT HOOD; PROPERGLOVESStorage Color Code: G - Green (General Storage)
16161616. . . . Labeling InfoLabeling InfoLabeling InfoLabeling InfoLabel Hazard WarningLabel Hazard WarningLabel Hazard WarningLabel Hazard Warning DANGER
Harmful if inhaled or swallowed. Causes eye burns. Causes skin irritation. Dust is irritating to theeyes and respiratory tract.
Label PrecautionsLabel PrecautionsLabel PrecautionsLabel Precautions Avoid breathing dust. Do not get in eyes and avoid contact with skin and clothing. Do not taste orswallow. Use only with adequate ventilation. Keep container closed. Wash thoroughly afterhandling.
Label First AidLabel First AidLabel First AidLabel First Aid Immediately flush eyes with plenty of water for at least 15 minutes. Immediately flush skin withplenty of water. If gas/fume/vapor/dust/mist from the material is inhaled, remove the affectedperson immediately to fresh air. Get medical attention immediately. IF SWALLOWED:Immediately call a POISON CENTER or doctor/physician. Do not induce vomiting without advicefrom poison control center. If vomiting occurs, keep head low so that stomach content doesn't getinto the lungs. Do not use mouth-to-mouth method if victim ingested the substance.
17171717. . . . Other InformationOther InformationOther InformationOther InformationNFPA ratingsNFPA ratingsNFPA ratingsNFPA ratings Health: 2
Flammability: 0Instability: 0
DisclaimerDisclaimerDisclaimerDisclaimer THE INFORMATION PRESENTED IN THIS MATERIAL SAFETY DATA SHEET (MSDS/SDS)WAS PREPARED BY TECHNICAL PERSONNEL BASED ON DATA THAT THEY BELIEVE INTHEIR GOOD FAITH JUDGMENT IS ACCURATE. HOWEVER, THE INFORMATION PROVIDEDHEREIN IS PROVIDED “AS IS,” AND AVANTOR PERFORMANCE MATERIALS MAKES ANDGIVES NO REPRESENTATIONS OR WARRANTIES WHATSOEVER, AND EXPRESSLYDISCLAIMS ALL WARRANTIES REGARDING SUCH INFORMATION AND THE PRODUCT TOWHICH IT RELATES, WHETHER EXPRESS, IMPLIED, OR STATUTORY, INCLUDINGWITHOUT LIMITATION, WARRANTIES OF ACCURACY, COMPLETENESS,MERCHANTABILITY, NON-INFRINGEMENT, PERFORMANCE, SAFETY, SUITABILITY,STABILITY, AND FITNESS FOR A PARTICULAR PURPOSE, AND ANY WARRANTIES ARISINGFROM COURSE OF DEALING, COURSE OF PERFORMANCE, OR USAGE OF TRADE. THISMSDS/SDS IS INTENDED ONLY AS A GUIDE TO THE APPROPRIATE PRECAUTIONARYHANDLING OF THE MATERIAL BY A PROPERLY TRAINED PERSON USING THIS PRODUCT,AND IS NOT INTENDED TO BE COMPREHENSIVE AS TO THE MANNER AND CONDITIONSOF USE, HANDLING, STORAGE, OR DISPOSAL OF THE PRODUCT. INDIVIDUALSRECEIVING THIS MSDS/SDS MUST ALWAYS EXERCISE THEIR OWN INDEPENDENTJUDGMENT IN DETERMINING THE APPROPRIATENESS OF SUCH ISSUES. ACCORDINGLY,AVANTOR PERFORMANCE MATERIALS ASSUMES NO LIABILITY WHATSOEVER FOR THEUSE OF OR RELIANCE UPON THIS INFORMATION. NO SUGGESTIONS FOR USE AREINTENDED AS, AND NOTHING HEREIN SHALL BE CONSTRUED AS, A RECOMMENDATIONTO INFRINGE ANY EXISTING PATENTS OR TO VIOLATE ANY FEDERAL, STATE, LOCAL, ORFOREIGN LAWS. AVANTOR PERFORMANCE MATERIALS REMINDS YOU THAT IT IS YOURLEGAL DUTY TO MAKE ALL INFORMATION IN THIS MSDS/SDS AVAILABLE TO YOUREMPLOYEES.
Issue dateIssue dateIssue dateIssue date 08-30-2011
Material name: ZINC SULFATE HEPTAHYDRATEMSDS ID: Z4560 Version #: 02 Revision date: 08-30-2011
MSDS US COV
6 / 6
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Revision Date 08.08.2017 Version 1.2
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 16
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 103943
Product name Iron(III) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph
Eur
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.
CAS-No. 10025-77-1
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Reagent for analysis
For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * 8th Floor, Godrej One,
Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079
India * Tel: 0091 22 6210 9000
Responsible Department Quality Assurance * Merck Life Science Private Limited *
e-mail: [email protected] *
Tel : +91-2267863131-6
1.4 Emergency telephone
number
Please contact the regional company representation in your country.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 103943
Product name Iron(III) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 16
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
Classification (REGULATION (EC) No 1272/2008)
Acute toxicity, Category 4, Oral, H302
Skin irritation, Category 2, H315
Serious eye damage, Category 1, H318
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Hazard pictograms
Signal word
Danger
Hazard statements
H302 Harmful if swallowed.
H315 Causes skin irritation.
H318 Causes serious eye damage.
Precautionary statements
Prevention
P280 Wear eye protection.
Response
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
P313 Get medical advice/ attention.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 103943
Product name Iron(III) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 16
Reduced labelling (≤125 ml)
Hazard pictograms
Signal word
Danger
Hazard statements
H318 Causes serious eye damage.
Precautionary statements
P280 Wear eye protection.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing.
P313 Get medical advice/ attention.
CAS-No. 10025-77-1
2.3 Other hazards
None known.
SECTION 3. Composition/information on ingredients
3.1 Substance
Formula FeCl₃ * 6 H₂O Cl₃Fe * 6 H₂O (Hill)
EC-No. 231-729-4
Molar mass 270.33 g/mol
Hazardous components (REGULATION (EC) No 1272/2008)
Chemical name (Concentration)
CAS-No. Registration number Classification
iron(III) chloride hexahydrate (<= 100 % )
10025-77-1 *)
Acute toxicity, Category 4, H302
Skin irritation, Category 2, H315
Serious eye damage, Category 1, H318
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 103943
Product name Iron(III) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 4 of 16
*) A registration number is not available for this substance as the substance or its use are exempted from registration according to Article
2 REACH Regulation (EC) No 1907/2006, the annual tonnage does not require a registration or the registration is envisaged for a later
registration deadline.
For the full text of the H-Statements mentioned in this Section, see Section 16.
3.2 Mixture
Not applicable
SECTION 4. First aid measures
4.1 Description of first aid measures
After inhalation: fresh air.
After skin contact: wash off with plenty of water. Remove contaminated clothing.
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove
contact lenses.
After swallowing: immediately make victim drink water (two glasses at most). Consult a
physician.
4.2 Most important symptoms and effects, both acute and delayed
irritant effects, Nausea, Vomiting, cardiovascular disorders
Risk of serious damage to eyes.
The following applies to soluble iron compounds: nausea and vomiting after swallowing. The
absorption of large quantities is followed by cardiovascular disorders. Toxic effect on liver and
kidneys.
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SECTION 5. Firefighting measures
5.1 Extinguishing media
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 103943
Product name Iron(III) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 5 of 16
Suitable extinguishing media
Use extinguishing measures that are appropriate to local circumstances and the surrounding
environment.
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Not combustible.
Ambient fire may liberate hazardous vapours.
Fire may cause evolution of:
Hydrogen chloride gas
5.3 Advice for firefighters
Special protective equipment for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.
Further information
Prevent fire extinguishing water from contaminating surface water or the ground water system.
Suppress (knock down) gases/vapours/mists with a water spray jet.
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid substance contact. Avoid inhalation of dusts. Ensure
adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an
expert.
Advice for emergency responders: Protective equipment see section 8.
6.2 Environmental precautions
Do not empty into drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills.
Observe possible material restrictions (see sections 7 and 10).
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 103943
Product name Iron(III) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 6 of 16
Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.
6.4 Reference to other sections
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handling
Observe label precautions.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and
face after working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Requirements for storage areas and containers
No metal containers.
Storage conditions
Tightly closed. Dry.
Recommended storage temperature see product label.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
Contains no substances with occupational exposure limit values.
8.2 Exposure controls
Engineering measures
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 103943
Product name Iron(III) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 7 of 16
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Eye/face protection
Tightly fitting safety goggles
Hand protection
full contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
splash contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 741 Dermatril® L (full contact),
KCL 741 Dermatril® L (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Other protective equipment
protective clothing
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 103943
Product name Iron(III) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 8 of 16
Respiratory protection
required when dusts are generated.
Recommended Filter type: Filter B-(P2)
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
Environmental exposure controls
Do not empty into drains.
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
Form solid
Colour tan
Odour of chlorine
Odour Threshold No information available.
pH ca. 1.8
at 10 g/l
25 °C
Melting point 37 °C
Boiling point/boiling range Not applicable
Flash point does not flash
Evaporation rate No information available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 103943
Product name Iron(III) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 9 of 16
Flammability (solid, gas) No information available.
Lower explosion limit Not applicable
Upper explosion limit Not applicable
Vapour pressure No information available.
Relative vapour density No information available.
Density No information available.
Relative density No information available.
Water solubility 920 g/l
at 20 °C
Partition coefficient: n-
octanol/water
No information available.
Auto-ignition temperature No information available.
Decomposition temperature No information available.
Viscosity, dynamic No information available.
Explosive properties Not classified as explosive.
Oxidizing properties none
9.2 Other data
Ignition temperature not combustible
Bulk density ca.600 - 1,200 kg/m3
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 103943
Product name Iron(III) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 10 of 16
SECTION 10. Stability and reactivity
10.1 Reactivity
Corrosive in contact with metals
10.2 Chemical stability
sensitive to moisture
10.3 Possibility of hazardous reactions
Risk of explosion with:
Alkali metals, Ethylene oxide
10.4 Conditions to avoid
Strong heating (decomposition).
Exposure to moisture
10.5 Incompatible materials
Metals, Mild steel
10.6 Hazardous decomposition products
in the event of fire: See section 5.
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Acute oral toxicity
LD50 Rat: 316 mg/kg
(anhydrous substance) (RTECS)
Symptoms: Nausea, Vomiting, Irritations of mucous membranes in the mouth, pharynx,
oesophagus and gastrointestinal tract.
Acute inhalation toxicity
Symptoms: Possible damages:, Irritation symptoms in the respiratory tract.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 103943
Product name Iron(III) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 11 of 16
Acute dermal toxicity
LD50 Dermal Rat: > 2,000 mg/kg
(External MSDS) (anhydrous substance)
Skin irritation
Rabbit
Result: Irritations
(anhydrous substance) (IUCLID)
Causes skin irritation.
Eye irritation
Rabbit
Result: Severe irritations
OECD Test Guideline 405
(anhydrous substance)
Causes serious eye damage.
Sensitisation
This information is not available.
Germ cell mutagenicity
Genotoxicity in vivo
In vivo micronucleus test
Mouse
Result: negative
(External MSDS) (anhydrous substance)
Genotoxicity in vitro
Ames test
Result: negative
Method: OECD Test Guideline 471
(anhydrous substance)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 103943
Product name Iron(III) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 12 of 16
Mutagenicity (mammal cell test): micronucleus.
Result: negative
Method: OECD Test Guideline 487
(anhydrous substance)
Carcinogenicity
This information is not available.
Reproductive toxicity
This information is not available.
Teratogenicity
This information is not available.
Specific target organ toxicity - single exposure
This information is not available.
Specific target organ toxicity - repeated exposure
This information is not available.
Aspiration hazard
This information is not available.
11.2 Further information
After absorption of large quantities:
cardiovascular disorders
Toxic effect on:
Liver, Kidney
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
SECTION 12. Ecological information
12.1 Toxicity
Toxicity to fish
LC50 Lepomis macrochirus (Bluegill sunfish): 20.3 mg/l; 96 h
(External MSDS) (anhydrous substance)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 103943
Product name Iron(III) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 13 of 16
Toxicity to daphnia and other aquatic invertebrates
Immobilization EC50 Daphnia magna (Water flea): 9.6 mg/l; 48 h
OECD Test Guideline 202
(anhydrous substance)
Toxicity to algae
ErC50 Pseudokirchneriella subcapitata (green algae): 6.9 mg/l; 72 h
OECD Test Guideline 201
(anhydrous substance)
NOEC Pseudokirchneriella subcapitata (green algae): 2.4 mg/l; 72 h
OECD Test Guideline 201
(anhydrous substance)
Toxicity to fish (Chronic toxicity)
NOEC Pimephales promelas (fathead minnow): 0.33 mg/l; 33 d
(External MSDS) (anhydrous substance)
Toxicity to daphnia and other aquatic invertebrates (Chronic toxicity)
NOEC Daphnia magna (Water flea): 0.7 mg/l; 21 d
(External MSDS) (anhydrous substance)
12.2 Persistence and degradability
Biodegradability
The methods for determining the biological degradability are not applicable to inorganic
substances.
12.3 Bioaccumulative potential
No information available.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.
12.6 Other adverse effects
Additional ecological information
Product reacts with water.
The following may develop after reaction of the product with water:
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 103943
Product name Iron(III) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 14 of 16
hydrochloric acid
Discharge into the environment must be avoided.
SECTION 13. Disposal considerations
Waste treatment methods
Waste material must be disposed of in accordance with the national and local regulations. Leave
chemicals in original containers. No mixing with other waste. Handle uncleaned containers like
the product itself.
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Sea transport (IMDG)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 103943
Product name Iron(III) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 15 of 16
National legislation
Storage class 10 - 13
15.2 Chemical safety assessment
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Full text of H-Statements referred to under sections 2 and 3.
H302 Harmful if swallowed.
H315 Causes skin irritation.
H318 Causes serious eye damage.
Training advice
Provide adequate information, instruction and training for operators.
Labelling
Hazard pictograms
Signal word
Danger
Hazard statements
H302 Harmful if swallowed.
H315 Causes skin irritation.
H318 Causes serious eye damage.
Precautionary statements
Prevention
P280 Wear eye protection.
Response
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 103943
Product name Iron(III) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 16 of 16
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
P313 Get medical advice/ attention.
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
Sigma-Aldrich - I6758 Page 1 of 7
SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 30.03.2016
Print Date 25.05.2018 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA
SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1 Product identifiers Product name : Isopropyl β-D-1-thiogalactopyranoside
Product Number : I6758 Brand : Sigma-Aldrich REACH No. : A registration number is not available for this substance as the substance
or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.
CAS-No. : 367-93-1
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances
1.3 Details of the supplier of the safety data sheet
Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA
1.4 Emergency telephone number
Emergency Phone # : +91 98802 05043
SECTION 2: Hazards identification
2.1 Classification of the substance or mixture
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008 Pictogram none Signal word none Hazard statement(s) none Precautionary statement(s) none Supplemental Hazard Statements
none
Safety data sheet available on request.
2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Sigma-Aldrich - I6758 Page 2 of 7
SECTION 3: Composition/information on ingredients
3.2 Mixtures Synonyms : Isopropyl β-D-thiogalactoside
IPTG
Formula : C9H18O5S
Molecular weight : 238.3 g/mol No components need to be disclosed according to the applicable regulations.
SECTION 4: First aid measures
4.1 Description of first aid measures
General advice Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact Wash off with soap and plenty of water. Consult a physician.
In case of eye contact Flush eyes with water as a precaution.
If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed No data available
SECTION 5: Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture Carbon oxides, Sulphur oxides
5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information No data available
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
Sigma-Aldrich - I6758 Page 3 of 7
6.4 Reference to other sections For disposal see section 13.
SECTION 7: Handling and storage
7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Recommended storage temperature 2 - 8 °C
hygroscopic Storage class (TRGS 510): Combustible Solids
7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
8.2 Exposure controls
Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
Personal protective equipment
Eye/face protection Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Sigma-Aldrich - I6758 Page 4 of 7
Body Protection Impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (EN 143) respirator cartridges as a backup to engineering controls. If th full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
SECTION 9: Physical and chemical properties
9.1 Information on basic physical and chemical properties
a) Appearance Form: solid
b) Odour No data available
c) Odour Threshold No data available
d) pH No data available
e) Melting point/freezing point
105 °C
f) Initial boiling point and boiling range
No data available
g) Flash point No data available
h) Evaporation rate No data available
i) Flammability (solid, gas) No data available
j) Upper/lower flammability or explosive limits
No data available
k) Vapour pressure No data available
l) Vapour density No data available
m) Relative density No data available
n) Water solubility No data available
o) Partition coefficient: n-octanol/water
No data available
p) Auto-ignition temperature
No data available
q) Decomposition temperature
No data available
r) Viscosity No data available
s) Explosive properties No data available
t) Oxidizing properties No data available
9.2 Other safety information No data available
SECTION 10: Stability and reactivity
10.1 Reactivity No data available
Sigma-Aldrich - I6758 Page 5 of 7
10.2 Chemical stability Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions No data available
10.4 Conditions to avoid Exposure to moisture
10.5 Incompatible materials Strong oxidizing agents
10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Sulphur oxides Other decomposition products - No data available In the event of fire: see section 5
SECTION 11: Toxicological information
11.1 Information on toxicological effects
Acute toxicity No data availableIsopropyl-β-D-thiogalactopyranoside
Skin corrosion/irritation No data available(Isopropyl-β-D-thiogalactopyranoside)
Serious eye damage/eye irritation No data available(Isopropyl-β-D-thiogalactopyranoside)
Respiratory or skin sensitisation No data available(Isopropyl-β-D-thiogalactopyranoside)
Germ cell mutagenicity No data available(Isopropyl-β-D-thiogalactopyranoside)
Carcinogenicity
IARC: 2B - Group 2B: Possibly carcinogenic to humans (1,4-Dioxane)
Reproductive toxicity
No data available(Isopropyl-β-D-thiogalactopyranoside)
Specific target organ toxicity - single exposure No data available(Isopropyl-β-D-thiogalactopyranoside)
Specific target organ toxicity - repeated exposure No data available
Aspiration hazard No data available(Isopropyl-β-D-thiogalactopyranoside)
Additional Information RTECS: Not available To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Isopropyl-β-D-thiogalactopyranoside)
SECTION 12: Ecological information
12.1 Toxicity No data available
12.2 Persistence and degradability No data available
Sigma-Aldrich - I6758 Page 6 of 7
12.3 Bioaccumulative potential No data available
12.4 Mobility in soil No data available(Isopropyl-β-D-thiogalactopyranoside)
12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
12.6 Other adverse effects No data available
SECTION 13: Disposal considerations
13.1 Waste treatment methods
Product Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chem scrubber.
Contaminated packaging Dispose of as unused product.
SECTION 14: Transport information
14.1 UN number ADR/RID: - IMDG: - IATA: -
14.2 UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods
14.3 Transport hazard class(es) ADR/RID: - IMDG: - IATA: -
14.4 Packaging group ADR/RID: - IMDG: - IATA: -
14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user No data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out
SECTION 16: Other information
Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.
Sigma-Aldrich - I6758 Page 7 of 7
© 2015 Sigma-Aldrich Co. LLC. All rights reserved. SIGMA-ALDRICH is a trademark of Sigma-Aldrich Co. LLC, registered in the US and other countries. Aldrich brand products are sold through Sigma-Aldrich, Inc. Purchaser must determine the suitability of the product(s) for their particular use. Additional terms and conditions may apply. Please see product information on the Sigma-Aldrich website at www.sigmaaldrich.com and/or on
the reverse side of the invoice or packing slip.
85390 Silicon Antifoam Characteristics SILICONE ANTIFOAM, which contains 20 % active ingredient and 33 % solids, is a versatile antifoam that is comparatively rich in emulsifier but is nonetheless easily metered because it has a relatively low viscosity. Since SILICONE ANTIFOAM also possesses high resistance to alkalis and acids, it may further be used in a wide range of applications in which pH is critical. Application SILICONE ANTIFOAM has proved ideal for tackling foam in textile auxiliaries and processes, for incorporation into cooling lubricants based on mineral oils, for separation of monomers from dispersions and conversion of dispersion into derivatives. SILICONE ANTIFOAM is a useful auxiliary for combating foam generated in surfactant containing formulations employed in the most diverse areas, such as the agrochemicals (plant protection agents), cleaners and petrochemicals industries. SILICONE ANTIFOAM is also an efficient defoamer for treating wastewaster. Processing As SILICONE ANTIFOAM is a low-viscosity emulsion, it can be metered readily, with stable dispersions easily attainable in high-viscosity formulations. In low viscosity products, preliminary compatibility and stability tests should be performed on the system to be de-foamed. The amount to add to liquid formulations depends on the desired degree of foam control, but usually lies between 0.1 and 2 %. If SILICONE ANTIFOAM is to be added during a process, we recommend pre-diluting it with cold water in a ratio of 1:1 to 1:10. If feed pumps are used, they should be of the low shear force type. Storage SILICONE ANTIFOAM has a recommended retest period of 16 months when stored at room temperature in the tightly closed original container. The recommended retest date of each lot appears on the respective Certificate of Analysis. Storage beyond the date specified on the label does not necessarily mean that the product is no longer usable. In this case however, the properties required for the intended use must be checked for quality assurance reasons. Product data
Property Method Unit Value Appearance white Active content, approx. [%] 20 Solids content, approx. microwave oven [%] 33 Ionic nature Nonionic Viscosity (25 °C), approx. spindle 1, 50 rpm [mPa s] 150 pH, approx. indicator strips 5.0–8.0 Density (25 °C), approx. DIN 12791 [g/mL] 1.0
These figures are only intended as a guide and should not be used in preparing specifications. They refer to manufacturer information. Precautions and Disclaimer This product is for R&D use only, not for drug, household, or other uses. Please consult the Material Safety Data Sheet for information regarding hazards and safe handling practices.
Thiamine Hydrochloride
Products Covered :
Section 1 – Product Information
Product Regulatory Data Sheet
A number of the cGMP produced products that are sold by Avantor Performance Materials, LLC. may not be originally manufactured at our sites. However, we perform the analytical and stability testing for these products and repackage the products where applicable. With ISO and cGMP procedures in place at our facilities we can ensure, and take complete responsibility for, the traceability and quality of the finished, packaged product that we offer.
The original manufacturer and address will be referenced on the Certificate of Analysis as an alpha or alpha-numeric manufacturer code rather than listing the full name and address. This practice is compliant with both ICH Q7 Good Manufacturing Guidance for Active Pharmaceutical Ingredients (APIs) and IPEC guidelines and it meets cGMP requirements. For instructions to decipher the manufacturer reference code please consult our website. Instructions can be found in the Ask Avantor QA Center of the support section of our web site or by directly linking to Ask Avantor Keyword: Manufacturer Code.
Section 2 – Manufacturing, Packaging and Release Site Information
*MOC = Management of Change
The products in Section 1 are manufactured according to current Good Manufacturing Practices (cGMPs) as set forth by International Pharmaceutical Excipients Council (IPEC) guidelines.
Brand Product Code Product Description MOC*
J.T.Baker® 4110 Thiamine Hydrochloride, U.S.P. - F.C.C. R
Macron Fine Chemicals™
2722 Thiamine Hydrochloride, U.S.P. R
Page 1 of 5Rev. 5; November 15, 2017 Thiamine Hydrochloride
67-03-8CAS #:
Section 3 – Physical/Chemical Information
Manufacturing Process:
Synthesis
Raw Material Origin:
Chemical
Section 4 – Regulatory Information
Please see the current product specifications at www.AvantorInc.com.
DMF:
BSE/TSE Status:
The products listed do not contain cereals containing gluten (i.e. wheat, rye, oats, barley, spelt, kamut or their hybridized strains), malt, triticale, gluten, other grains, corn, soy, soybeans, eggs, yeast, canola, milk, dairy products, fish, crustacean shellfish, seafood products, tree nuts, peanuts, nut products (i.e. Almond (Amygdalus communis L.), Hazelnut (Corylus avellana), Walnut (Juglans regia), Cashew (Anacardium occidentale), Pecan nut (Carya illiniesis (Wangenh.) K. Koch), Brazil nut (Bertholletia excelsa), Pistachio nut (Pistacia vera), Macadamia nut and Queensland nut (Macadamia ternifolia)), seed products (sesame seeds and products thereof), natural grape products, natural flavors, artificial flavors, celery, mustard, lactose, sulfites, elemental sulfur, preservatives, lupine and products thereof, MSG, disodium guanylate/inosinate, artificial sweeteners, phenylalanine, additives, colorants, dyes, or natural rubber (latex). These products are manufactured using cGMP guidelines which provide controls that allow no potential for cross contamination of any allergens or other products.
The subject materials, including any raw materials and processing aids, are NOT subject to genetic modification.
Only Class 3 solvent (Ethanol) is likely to be present. All are below Option 1 limits. No other Class 1, 2, 3, or other Residual Solvents, as described in USP <467>, are used or produced during manufacture.
Please see attached summary for Elemental Impurity information for listed products.
Allergen/Hypersensitivities Information:
GMO Information:
Residual Solvents/Organic Volatile Impurities (OVI) Information:
The subject materials are manufactured from raw materials that contain NO animal parts, products, and/or by-products nor do they come in contact with animal parts, products, and/or by-products.
Aflatoxins as defined by IPEC (International Pharmaceutical Excipient Council) are a group of structurally related toxic compounds produced by certain strains of the fungi Aspergillus flavus and A. parasiticus. Under favorable conditions of temperature and humidity, these fungi grow on certain foods and feeds, resulting in the production of aflatoxins. The most pronounced contamination has been encountered in tree nuts, peanuts, and other oilseeds, including corn and cottonseed. Aflatoxicosis is poisoning that results from ingestion of aflatoxins in contaminated food or feed.
Avantor does not analyze the product(s) for the presence of aflatoxin content. However, we can confirm the subject materials do not contain, nor are they manufactured with any product commonly affected by aflatoxins. These
Aflatoxins:
Avantor Performance Materials, LLC. Does not carry a Drug Master File for these products.
Elemental Impurities:
Compendial Compliance:
Page 2 of 5Rev. 5; November 15, 2017 Thiamine Hydrochloride
Kosher Status:
The subject materials are not Kosher Certified.
Halal Status:
The subject materials are not Halal Certified.
include cereals (maize, sorghum, pearl millet, rice, wheat), oilseeds (peanut, soybean, sunflower, cotton), spices (chili peppers, black pepper, coriander, turmeric, ginger), and tree nuts (almond, pistachio, walnut, coconut, Brazil nut)
GRAS Status:
The United States Food and Drug Administration (FDA) have acknowledged that thiamine hydrochloride is a Direct Food Substances Affirmed As Generally Recognized as Safe (GRAS) in foods when used in accordance with the requirements and limitations per 21 CFR parts 184.1875.
Please refer to the customer support section of our website for our most up to date listing of Kosher products. (Ask Avantor Keyword: Kosher)
Please refer to the customer support section of our website for our most up to date listing of Halal products. (Ask Avantor Keyword: Halal)
Page 3 of 5Rev. 5; November 15, 2017 Thiamine Hydrochloride
Section 5 – Miscellaneous Product Information
reported as YYYY/MM/DD from our ERP system effective April 30, 2012. For example, the Manufactured Date for October 1, 2012 would be reported as 2012/10/01
information concerning our lot/batch numbering system. (Ask Avantor Keyword: Lot Number)
batch of the source supplier.
If a product has an assigned expiration or retest period, the date will appear on the
Bulk food chemicals that are intended for the use in manufacturing of finished food products or for products that Bulk food chemicals that are intended for use in manufacturing of finished food products or for products that are to be processed, labeled, and/or repacked at a site other than where it's orginally processed or packed, are exempt from the Nutrient Content Evaluation and Labeling Requirements. (21 CFR 101.9(j)(9))
Please refer to the customer support section of our website for information concerning
Country of Origin is indicated on the product Certificate of Analysis. Please contact
of specific storage conditions listed on the Avantor specification sheet or certificate of analysis, our products are to be stored in ambient conditions of temperature and humidity. We do not formally tie any specific temperature or humidity range with the ‘ambient’ storage designation, but an example of a common temperature interpretation is 15-30°C. Our products are also packaged to protect from the normal variation in humidity during storage and shipment. Further handling and storage information may be found in Section 7 of the product SDS sheet.
Rev. 0; Oct. 1, 2007 – IPEC EIP format (DRH)Rev. 1; Jan. 2, 2009 - Section 4: Residual Solvents statement revised; Section 7: updated telephone # for Customer Service Director; Entire Document: added keywords to Solv It Center links. (KES)Rev. 2; Jan. 13, 2010 – Entire document: new letterhead and changed all references of “Solv IT Center” to “AskMBI.”; Section 7: updated TS manager info. Section 4: added GRAS section (KES)Rev. 3; Nov. 8, 2011 –Entire document: new letterhead (company name & headquarters address); changed all references of “AskMBI” to “AskAvantor”; updated website links to new website; minor formatting; Section 1: Mallinckrodt brand name changed to Macron; added MOC code; Section 2: added GMP statement; Section 4: expanded Allergens list; added Residual Metallic Catalysts Information; Section 5: Added Nutritional/Supplemental Facts Labeling and Organic Status statements; Section 7: updated contact information. (PH/JLW)Rev. 4; Aug. 12, 2013 –Section 4: added add’l allergens as listed in EU Directive 2003/89/EC; separated Kosher/Halal
Section 6 – Revision History
The Manufactured Date and Expiration/Retest Date on the C of A are
Please refer to the customer support section of our website for
A “batch” is a homogeneous unit of production; each batch of material is from one single
certificate of analysis. For products that do not have assigned dates please contact Technical Support through the customer support section of our website for our product stability profiles. (Ask Avantor Keyword: Expiration)
our Management of Change program. (Ask Avantor Keyword: MOC)
our Trade Compliance Department if you require further documentation. ([email protected])
Please refer to the product Certificate of Analysis/Product Specifications. In the absenceStorage Requirements:
Country of Origin Statement:
Management of Change:
Shelf Life Information:
Batch Definition:
Lot Numbering System and Batch Description:
Certificate of Analysis Date Format:
Nutritional/Supplement Facts Labeling:
Organic Status:The products listed in Section 1 are not certified as organic. However, to the best of our knowledge, the product is not produced using Ionizing Radiation as described in 21 CFR 179.26 or Sewage Sludge as described in 7 CFR Section 205.2.
Page 4 of 5Rev. 5; November 15, 2017 Thiamine Hydrochloride
status and added certification statement; Section 5: added Management of Change information; Added COA Date Format statement Section 7: removed contact list table and added CS/TS contact information. (MCH)Rev.5; November 15, 2017- Entire document: new letterhead format (company name and headquarters address); Section4: updated residual solvent statement and added Elemental Impurities information, added Aflatoxin Statement; Section 5: added Storage Requirement, Batch Definition, and Country of Origin Statements (SR)
This electronic document is valid without a signature.
Section 7 – Contact Information
Customer Service Phone: 1-855-282-6867 1-610-573-2600 (outside U.S.) Fax: 1-610-573-2650 [email protected]
Technical Service Phone: 1-855-282-6867 1-610-573-2600 (outside U.S.) Fax: 1-610-573-2650 [email protected]
Trademarks are owned by Avantor Performance Materials, LLC. or its affiliates unless otherwise noted.© 2017 Avantor Performance Materials, LLC.
The most current revision of this document is maintained on our website. Reviews and revisions are performed as warranted due to product changes or as part of the supplier audit cycle.
While the above information is provided in good faith and believed to be accurate as of the date provided, Avantor Performance Materials, LLC and its affiliated companies ("Avantor") make no representations or warranties as to the accuracy or completeness of such information. Use of the information is subject to Avantor's confidentiality requirements as applicable. All Avantor products are subject to Avantor’s terms and conditions of sale including the limitations of liability contained therein and any contrary terms and conditions are expressly rejected. As Avantor has no control over purchasers’ uses of its products or information, Avantor expressly disclaims all liability with respect to same.
Page 5 of 5Rev. 5; November 15, 2017 Thiamine Hydrochloride
Page 1 of 4
Material Name: Thiamine Hydrochloride Product codes: : 4110, 2722 Date: January 4, 2017
Source/Type of Excipient: ☐ Mineral; ☐ Mineral derived; ☐ Plant; ☐ Plant derived; ☒ Synthetic; ☐ Fermentation derived
Other (explain):
Elemental Impurity
Class Likely to be Present
If Known, Please Identify the Expected
Concentration /Units (or Range)
Analytical Method Used (and Limit of Detection if
Available)
Comments regarding source of information (i.e.;
number of lots tested, frequency of testing,
process understanding, etc.)
Arsenic (inorganic)
As 1 Yes No Unknown <0.1 ppm ICP-OES (MRL=0.1 ppm) Manufacturer supplied information
Cadmium Cd 1 Yes No Unknown <0.1 ppm ICP-OES (MRL=0.1 ppm) Manufacturer supplied information
Mercury (inorganic)
Hg 1 Yes No Unknown <0.01 ppm Fluorescence (MRL=0.01 ppm)
Manufacturer supplied information
Lead Pb 1 Yes No Unknown <0.1 ppm ICP-OES (MRL=0.1 ppm) Manufacturer supplied information
Cobalt Co 2A Yes No Unknown <0.1 ppm ICP-OES (MRL=0.1 ppm) Manufacturer supplied information
Nickel Ni 2A Yes No Unknown <0.2 ppm ICP-OES (MRL=0.2 ppm) Manufacturer supplied
Page 2 of 4
Elemental Impurity
Class Likely to be Present
If Known, Please Identify the Expected
Concentration /Units (or Range)
Analytical Method Used (and Limit of Detection if
Available)
Comments regarding source of information (i.e.;
number of lots tested, frequency of testing,
process understanding, etc.)
information
Vanadium V 2A Yes No Unknown <1 ppm ICP-OES (MRL=1 ppm) Manufacturer supplied information
Silver Ag 2B Yes No Unknown Not tested Manufacturer supplied information
Gold Au 2B Yes No Unknown Not tested Manufacturer supplied information
Iridium Ir 2B Yes No Unknown <1 ppm ICP-OES (MRL=1 ppm) Manufacturer supplied information
Osmium Os 2B Yes No Unknown <1 ppm ICP-OES (MRL=1 ppm) Manufacturer supplied information
Palladium Pd 2B Yes No Unknown <1 ppm ICP-OES (MRL=1 ppm) Manufacturer supplied information
Platinum Pt 2B Yes No Unknown <1 ppm ICP-OES (MRL=1 ppm) Manufacturer supplied information
Rhodium Rh 2B Yes No Unknown <1 ppm ICP-OES (MRL=1 ppm) Manufacturer supplied information
Ruthenium Ru 2B Yes No Unknown <1 ppm ICP-OES (MRL=1 ppm) Manufacturer supplied information
Selenium Se 2B Yes No Unknown <1 ppm ICP-OES (MRL=1 ppm) Manufacturer supplied information
Thallium Tl 2B Yes No Unknown <1 ppm ICP-OES (MRL=1 ppm) Manufacturer supplied information
Barium Ba 3 Yes No Unknown N/A Manufacturer supplied information
Page 3 of 4
Elemental Impurity
Class Likely to be Present
If Known, Please Identify the Expected
Concentration /Units (or Range)
Analytical Method Used (and Limit of Detection if
Available)
Comments regarding source of information (i.e.;
number of lots tested, frequency of testing,
process understanding, etc.)
Chromium Cr 3 Yes No Unknown <1 ppm ICP-OES (MRL=1 ppm) Manufacturer supplied information
Copper Cu 3 Yes No Unknown <0.4 ppm ICP-OES (MRL=0.4 ppm) Manufacturer supplied information
Lithium Li 3 Yes No Unknown Not tested. Manufacturer supplied information
Molybdenum Mo 3 Yes No Unknown <1 ppm ICP-OES (MRL=1 ppm) Manufacturer supplied information
Antimony Sb 3 Yes No Unknown <0.1 ppm ICP-OES (MRL=0.1 ppm) Manufacturer supplied information
Tin Sn 3 Yes No Unknown Not tested. Manufacturer supplied information
Reference: ICH Q3D Guideline for Elemental Impurities, Step 4 version, September 2014
David L. Cugini, Sr. QA Analyst
Prepared by the Technical Service Department Avantor™ Performance Materials, Inc. 3477 Corporate Parkway Suite #200
Center Valley, PA 18034 1-800-669-8230
Avantor™ Performance Materials, Inc provides the information contained herein in good faith but makes no representations or warranties, either expressed or implied, including without limitation any warranties of merchantability or fitness for a particular purpose with respect to the information set forth herein or the product(s) to which the information refers. Accordingly, Avantor™ Performance Materials, Inc will not be responsible for damages resulting from the use of or reliance upon this information.
Page 4 of 4
Trademarks are owned by Avantor Performance Materials, Inc. or its affiliates unless otherwise noted. © 2016 Avantor Performance Materials, Inc.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Revision Date 31.07.2017 Version 2.6
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 17
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE®
ACS,Reag. Ph Eur,ISO
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.
CAS-No. 1310-73-2
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Reagent for analysis, Chemical production
For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * 8th Floor, Godrej One,
Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079
India * Tel: 0091 22 6210 9000
Responsible Department Quality Assurance * Merck Life Science Private Limited *
e-mail: [email protected] *
Tel : +91-2267863131-6
1.4 Emergency telephone
number
Please contact the regional company representation in your country.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 17
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
Classification (REGULATION (EC) No 1272/2008)
Corrosive to metals, Category 1, H290
Skin corrosion, Category 1A, H314
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Hazard pictograms
Signal word
Danger
Hazard statements
H290 May be corrosive to metals.
H314 Causes severe skin burns and eye damage.
Precautionary statements
Prevention
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
Response
P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 17
Reduced labelling (≤125 ml)
Hazard pictograms
Signal word
Danger
Hazard statements
H314 Causes severe skin burns and eye damage.
Precautionary statements
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing.
P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.
CAS-No. 1310-73-2
2.3 Other hazards
None known.
SECTION 3. Composition/information on ingredients
3.1 Substance
Formula NaOH HNaO (Hill)
EC-No. 215-185-5
Molar mass 40.00 g/mol
Hazardous components (REGULATION (EC) No 1272/2008)
Chemical name (Concentration)
CAS-No. Registration number Classification
sodium hydroxide (<= 100 % )
PBT/vPvB: Not applicable for inorganic substances
1310-73-2 *)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 4 of 17
Corrosive to metals, Category 1, H290
Skin corrosion, Category 1A, H314
*) A registration number is not available for this substance as the substance or its use are exempted from registration according to Article
2 REACH Regulation (EC) No 1907/2006, the annual tonnage does not require a registration or the registration is envisaged for a later
registration deadline.
For the full text of the H-Statements mentioned in this Section, see Section 16.
3.2 Mixture
Not applicable
SECTION 4. First aid measures
4.1 Description of first aid measures
General advice
First aider needs to protect himself.
After inhalation: fresh air. Call in physician.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower. Call a physician immediately.
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove
contact lenses.
After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of
perforation). Call a physician immediately. Do not attempt to neutralise.
4.2 Most important symptoms and effects, both acute and delayed
Risk of blindness!
Irritation and corrosion, Cough, Shortness of breath, collapse, death
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 5 of 17
SECTION 5. Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Use extinguishing measures that are appropriate to local circumstances and the surrounding
environment.
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Not combustible.
Ambient fire may liberate hazardous vapours.
5.3 Advice for firefighters
Special protective equipment for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.
Further information
Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing
water from contaminating surface water or the ground water system.
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact. Ensure
adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an
expert.
Advice for emergency responders:
Protective equipment see section 8.
6.2 Environmental precautions
Do not let product enter drains.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 6 of 17
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see
sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation
of dusts.
6.4 Reference to other sections
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handling
Observe label precautions.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and
face after working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Requirements for storage areas and containers
No aluminium, tin, or zinc containers.
No metal containers.
Storage conditions
Tightly closed. Dry.
Recommended storage temperature see product label.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 7 of 17
sodium hydroxide (1310-73-2)
IN OEL Ceiling Limit Value: 2 mg/m³
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Eye/face protection
Tightly fitting safety goggles
Hand protection
full contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
splash contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 741 Dermatril® L (full contact),
KCL 741 Dermatril® L (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 8 of 17
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Other protective equipment
protective clothing
Respiratory protection
required when dusts are generated.
Recommended Filter type: Filter P 2 (acc. to DIN 3181) for solid and liquid particles of harmful
substances
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
Environmental exposure controls
Do not let product enter drains.
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
Form solid
Colour white
Odour odourless
Odour Threshold Not applicable
pH ca. > 14
at 100 g/l
20 °C
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 9 of 17
Melting point/range 319 - 322 °C
Boiling point/boiling range 1,390 °C
at 1,013 hPa
Flash point Not applicable
Evaporation rate No information available.
Flammability (solid, gas) The product is not flammable.
Lower explosion limit Not applicable
Upper explosion limit Not applicable
Vapour pressure at 20 °C
Not applicable
Relative vapour density No information available.
Density 2.13 g/cm3
at 20 °C
Relative density No information available.
Water solubility 1,090 g/l
at 20 °C
Partition coefficient: n-
octanol/water
No information available.
Auto-ignition temperature No information available.
Decomposition temperature No information available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 10 of 17
Viscosity, dynamic No information available.
Explosive properties Not classified as explosive.
Oxidizing properties none
9.2 Other data
Ignition temperature Not applicable
Corrosion May be corrosive to metals.
SECTION 10. Stability and reactivity
10.1 Reactivity
See section 10.3
10.2 Chemical stability
hygroscopic
10.3 Possibility of hazardous reactions
Violent reactions possible with:
Acetone, Chlorine, Ethylene oxide, Fluorine, Hydrogen halides, Hydrazine hydrate,
hydroxylamine, Acid anhydrides, Acrolein, Acid chlorides, Acids, sulphuric acid, Chloroform,
Water, hydrogen peroxide, anhydrides, EPICHLOROHYDRIN, phosphides, halogen-halogen
compounds, trichloroethene, ALLYL ALCOHOL
can decompose violently in contact with:
Organic Substances, hydrogen sulphide
Risk of ignition or formation of inflammable gases or vapours with:
powdered aluminium, Ammonium salts, persulfates, Sodium borohydride, phosphorus, Oxides of
phosphorus, Halogenated hydrocarbon, Light metals, Metals
Risk of explosion/exothermic reaction with:
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 11 of 17
Bromine, Calcium, in powder form, furfuryl alcohol, Nitromethane, Peroxides, organic nitro
compounds, Nitriles, Acrylic monomers, SILVER NITRATE
Chloroform, with, Acetone
Nitrobenzene, with, Methanol
Nitrobenzene, with, salts
magnesium, Zinc, and, Tin, (in the presence of atmospheric oxygen and/or moisture)
10.4 Conditions to avoid
Moisture.
10.5 Incompatible materials
Aluminium, brass, Metals, metal alloys, Zinc, Tin
10.6 Hazardous decomposition products
in the event of fire: See section 5.
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Acute oral toxicity
Symptoms: If ingested, severe burns of the mouth and throat, as well as a danger of perforation
of the oesophagus and the stomach.
Acute inhalation toxicity
Symptoms: burns of mucous membranes, Cough, Shortness of breath, Possible damages:,
damage of respiratory tract
Acute dermal toxicity
This information is not available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 12 of 17
Skin irritation
Rabbit
Result: Causes burns.
(External MSDS)
Causes severe burns.
Eye irritation
Rabbit
Result: Irreversible effects on the eye
(ECHA)
Causes serious eye damage.
Risk of blindness!
Sensitisation
Patch test: human
Result: negative
(ECHA)
Germ cell mutagenicity
Genotoxicity in vitro
Mutagenicity (mammal cell test): micronucleus.
Result: negative
(Lit.)
Ames test
Result: negative
(IUCLID)
Carcinogenicity
This information is not available.
Reproductive toxicity
This information is not available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 13 of 17
Teratogenicity
This information is not available.
Specific target organ toxicity - single exposure
This information is not available.
Specific target organ toxicity - repeated exposure
This information is not available.
Aspiration hazard
This information is not available.
11.2 Further information
Systemic effects:
collapse, death
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
SECTION 12. Ecological information
12.1 Toxicity
Toxicity to fish
LC50 Gambusia affinis (Mosquito fish): 125 mg/l; 96 h
(External MSDS)
Toxicity to daphnia and other aquatic invertebrates
EC50 Ceriodaphnia (water flea): 40.4 mg/l; 48 h
(ECHA)
Toxicity to bacteria
EC50 Photobacterium phosphoreum: 22 mg/l; 15 min
(External MSDS)
12.2 Persistence and degradability
Biodegradability
The methods for determining the biological degradability are not applicable to inorganic
substances.
12.3 Bioaccumulative potential
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 14 of 17
No information available.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
PBT/vPvB: Not applicable for inorganic substances
12.6 Other adverse effects
Additional ecological information
Harmful effect due to pH shift.
Forms corrosive mixtures with water even if diluted.
Neutralisation possible in waste water treatment plants.
Discharge into the environment must be avoided.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 15 of 17
SECTION 13. Disposal considerations
Waste treatment methods
Waste material must be disposed of in accordance with the national and local regulations. Leave
chemicals in original containers. No mixing with other waste. Handle uncleaned containers like
the product itself.
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 UN number UN 1823
14.2 Proper shipping name SODIUM HYDROXIDE, SOLID
14.3 Class 8
14.4 Packing group II
14.5 Environmentally hazardous --
14.6 Special precautions for
user
yes
Tunnel restriction code E
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)
14.1 UN number UN 1823
14.2 Proper shipping name SODIUM HYDROXIDE, SOLID
14.3 Class 8
14.4 Packing group II
14.5 Environmentally hazardous --
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 16 of 17
14.6 Special precautions for
user
no
Sea transport (IMDG)
14.1 UN number UN 1823
14.2 Proper shipping name SODIUM HYDROXIDE, SOLID
14.3 Class 8
14.4 Packing group II
14.5 Environmentally hazardous --
14.6 Special precautions for
user
yes
EmS F-A S-B
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National legislation
Storage class 8B
15.2 Chemical safety assessment
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Full text of H-Statements referred to under sections 2 and 3.
H290 May be corrosive to metals.
H314 Causes severe skin burns and eye damage.
Training advice
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 17 of 17
Provide adequate information, instruction and training for operators.
Labelling
Hazard pictograms
Signal word
Danger
Hazard statements
H290 May be corrosive to metals.
H314 Causes severe skin burns and eye damage.
Precautionary statements
Prevention
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
Response
P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
MATERIAL SAFETY DATA SHEETMATERIAL SAFETY DATA SHEETMATERIAL SAFETY DATA SHEETMATERIAL SAFETY DATA SHEET
1111. . . . Product and Company IdentificationProduct and Company IdentificationProduct and Company IdentificationProduct and Company IdentificationMaterial nameMaterial nameMaterial nameMaterial name TOLUENETOLUENETOLUENETOLUENEVersion #Version #Version #Version # 02Revision dateRevision dateRevision dateRevision date 08-30-2011Chemical nameChemical nameChemical nameChemical name TOLUENECAS #CAS #CAS #CAS # 108-88-3Product CodesProduct CodesProduct CodesProduct Codes J.T.Baker: 5375, 5584, 5812, 9336, 9351, 9364, 9456, 9457, 9459, 9460, 9462, 9466, 9472,J.T.Baker: 5375, 5584, 5812, 9336, 9351, 9364, 9456, 9457, 9459, 9460, 9462, 9466, 9472,J.T.Baker: 5375, 5584, 5812, 9336, 9351, 9364, 9456, 9457, 9459, 9460, 9462, 9466, 9472,J.T.Baker: 5375, 5584, 5812, 9336, 9351, 9364, 9456, 9457, 9459, 9460, 9462, 9466, 9472,
9476947694769476Macron: 4483, 8604, 8608, V560Macron: 4483, 8604, 8608, V560Macron: 4483, 8604, 8608, V560Macron: 4483, 8604, 8608, V560
Synonym(s)Synonym(s)Synonym(s)Synonym(s) Methylbenzene; Toluol; PhenylmethaneManufacturer informationManufacturer informationManufacturer informationManufacturer information Avantor Performance Materials, Inc.
3477 Corporate ParkwaySuite #200Center Valley, PA 18034 US24 Hour Emergency 908-859-2151Chemtrec 800-424-9300Customer Service 855-282-6867
2222. . . . Hazards IdentificationHazards IdentificationHazards IdentificationHazards IdentificationEmergency overviewEmergency overviewEmergency overviewEmergency overview DANGER
Flammable liquid and vapor. Will be easily ignited by heat, spark or flames. Harmful if inhaled orabsorbed through skin. Harmful or fatal if swallowed. Causes skin and eye irritation. Causesrespiratory tract irritation. High vapor concentrations may cause drowsiness and irritation of theeyes or respiratory tract. May damage fertility or the unborn child. Prolonged exposure may causechronic effects.
Potential health effectsPotential health effectsPotential health effectsPotential health effectsRoutes of exposureRoutes of exposureRoutes of exposureRoutes of exposure Inhalation. Ingestion. Skin contact. Eye contact.EyesEyesEyesEyes Causes eye irritation. High vapor/aerosol concentrations may be irritating.SkinSkinSkinSkin Harmful if absorbed through skin. Causes skin irritation. Prolonged or repeated contact with skin
may cause redness, itching, irritation and eczema/chapping.InhalationInhalationInhalationInhalation Harmful if inhaled. May cause irritation to the mucous membranes and upper respiratory tract. In
high concentrations, vapors and aerosol mists have a narcotic effect and may cause headache,fatigue, dizziness and nausea.
IngestionIngestionIngestionIngestion Harmful or fatal if swallowed. Ingestion may result in vomiting; aspiration (breathing) of vomitusinto lungs must be avoided as even small quantities may result in aspiration pneumonitis.
Target organsTarget organsTarget organsTarget organs Eyes. Respiratory system. Skin. Nervous System. Reproductive organs. Kidneys. Auditoryorgans.
Chronic effectsChronic effectsChronic effectsChronic effects Can cause nervous system damage. May cause adverse reproductive effects - such as birthdefects, miscarriages, or infertility based on animal data. Frequent or prolonged contact may defatand dry the skin, leading to discomfort and dermatitis.
Potential environmental effectsPotential environmental effectsPotential environmental effectsPotential environmental effects Toxic to aquatic organisms.
ComponentsComponentsComponentsComponents CAS #CAS #CAS #CAS # PercentPercentPercentPercent
3333. . . . Composition Composition Composition Composition / / / / Information on IngredientsInformation on IngredientsInformation on IngredientsInformation on Ingredients
108-88-3 99 - 100TOLUENE
Material name: TOLUENEMSDS ID: T3913 Version #: 02 Revision date: 08-30-2011
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4444. . . . First Aid MeasuresFirst Aid MeasuresFirst Aid MeasuresFirst Aid MeasuresFirst aid proceduresFirst aid proceduresFirst aid proceduresFirst aid procedures
Eye contactEye contactEye contactEye contact Immediately flush with plenty of water for at least 15 minutes. If easy to do, remove contactlenses. Get medical attention.
Skin contactSkin contactSkin contactSkin contact In case of contact, immediately flush skin with plenty of water for at least 15 minutes whileremoving contaminated clothing and shoes. Get medical attention. Wash contaminated clothingbefore reuse. Destroy or thoroughly clean contaminated shoes.
InhalationInhalationInhalationInhalation Move to fresh air. If breathing is difficult, give oxygen. If breathing stops, provide artificialrespiration. Get medical attention immediately.
IngestionIngestionIngestionIngestion Call a physician or poison control center immediately. Do not induce vomiting. If vomiting occurs,the head should be kept low so that stomach vomit doesn't enter the lungs.
Notes to physicianNotes to physicianNotes to physicianNotes to physician Treat symptomatically. Symptoms may be delayed.General adviceGeneral adviceGeneral adviceGeneral advice Ensure that medical personnel are aware of the material(s) involved, and take precautions to
protect themselves. Show this safety data sheet to the doctor in attendance.
5555. . . . Fire Fighting MeasuresFire Fighting MeasuresFire Fighting MeasuresFire Fighting MeasuresFlammable propertiesFlammable propertiesFlammable propertiesFlammable properties HIGHLY FLAMMABLE! Vapors may cause a flash fire or ignite explosively. Vapors may travel
considerable distance to a source of ignition and flash back. Heat may cause the containers toexplode.
Extinguishing mediaExtinguishing mediaExtinguishing mediaExtinguishing mediaSuitable extinguishingSuitable extinguishingSuitable extinguishingSuitable extinguishingmediamediamediamedia
Water spray. Foam. Dry powder. Carbon dioxide (CO2).
Unsuitable extinguishingUnsuitable extinguishingUnsuitable extinguishingUnsuitable extinguishingmediamediamediamedia
Do not use water jet as an extinguisher, as this will spread the fire.
Protection of firefightersProtection of firefightersProtection of firefightersProtection of firefightersSpecific hazards arisingSpecific hazards arisingSpecific hazards arisingSpecific hazards arisingfrom the chemicalfrom the chemicalfrom the chemicalfrom the chemical
Can be ignited easily and burns vigorously. Vapor from the solvent may accumulate in containerheadspace resulting in flammability hazard.
Protective equipment forProtective equipment forProtective equipment forProtective equipment forfirefightersfirefightersfirefightersfirefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH(approved or equivalent) and full protective gear.
Fire fightingFire fightingFire fightingFire fightingequipment/instructionsequipment/instructionsequipment/instructionsequipment/instructions
Firefighters must use standard protective equipment including flame retardant coat, helmet withface shield, gloves, rubber boots, and in enclosed spaces, SCBA. Withdraw immediately in caseof rising sound from venting safety device or any discoloration of tanks due to fire. Movecontainers from fire area if you can do so without risk. For massive fire in cargo area, useunmanned hose holder or monitor nozzles, if possible. If not, withdraw and let fire burn out. Someof these materials, if spilled, may evaporate leaving a flammable residue. Cool containersexposed to flames with water until well after the fire is out.
Specific methodsSpecific methodsSpecific methodsSpecific methods In the event of fire and/or explosion do not breathe fumes. Use water spray to cool unopenedcontainers.
Hazardous combustion productsHazardous combustion productsHazardous combustion productsHazardous combustion products Carbon monoxide and carbon dioxide.
6666. . . . Accidental Release MeasuresAccidental Release MeasuresAccidental Release MeasuresAccidental Release MeasuresPersonal precautionsPersonal precautionsPersonal precautionsPersonal precautions Wear appropriate protective equipment and clothing during clean-up. Keep unnecessary
personnel away. Keep upwind. Keep out of low areas. Ventilate closed spaces before enteringthem. Do not touch damaged containers or spilled material unless wearing appropriate protectiveclothing. Local authorities should be advised if significant spillages cannot be contained.
Environmental precautionsEnvironmental precautionsEnvironmental precautionsEnvironmental precautions Prevent further leakage or spillage if safe to do so. Do not contaminate water. Avoid dischargeinto drains, water courses or onto the ground.
Methods for containmentMethods for containmentMethods for containmentMethods for containment ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Stop theflow of material, if this is without risk. Prevent entry into waterways, sewer, basements or confinedareas. Dike the spilled material, where this is possible.
Material name: TOLUENEMSDS ID: T3913 Version #: 02 Revision date: 08-30-2011
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Methods for cleaning upMethods for cleaning upMethods for cleaning upMethods for cleaning up Use only non-sparking tools. All equipment used when handling the product must be grounded.
Large Spills: Use a non-combustible material like vermiculite, sand or earth to soak up the productand place into a container for later disposal. Dike far ahead of spill for later disposal.
Small Spills: Wipe up with absorbent material (e.g. cloth, fleece). Collect in a non-combustiblecontainer for prompt disposal.
Never return spills in original containers for re-use. Clean surface thoroughly to remove residualcontamination. Clean up in accordance with all applicable regulations.
J. T. Baker SOLUSORB® solvent adsorbent is recommended for spills of this product.
7777. . . . Handling and StorageHandling and StorageHandling and StorageHandling and StorageHandlingHandlingHandlingHandling DO NOT handle, store or open near an open flame, sources of heat or sources of ignition. Protect
material from direct sunlight. Take precautionary measures against static discharges. Wearappropriate personal protective equipment. Avoid breathing mist or vapor. Avoid contact witheyes, skin, and clothing. Do not taste or swallow. Use only with adequate ventilation. Washthoroughly after handling. See Section 8 of the MSDS for Personal Protective Equipment.
StorageStorageStorageStorage Keep away from food, drink and animal feedingstuffs. Keep out of the reach of children. Keepcontainer tightly closed in a cool, well-ventilated place. Ground container and transfer equipmentto eliminate static electric sparks. Comply with all national, state, and local codes pertaining to thestorage, handling, dispensing, and disposal of flammable liquids.
Canada Canada Canada Canada - - - - British ColumbiaBritish ColumbiaBritish ColumbiaBritish Columbia
8888. . . . Exposure Controls Exposure Controls Exposure Controls Exposure Controls / / / / Personal ProtectionPersonal ProtectionPersonal ProtectionPersonal ProtectionOccupational exposure limitsOccupational exposure limitsOccupational exposure limitsOccupational exposure limits
MaterialMaterialMaterialMaterial TypeTypeTypeType ValueValueValueValue
TOLUENE (108-88-3) 20.0000 ppmTWA
Canada Canada Canada Canada - - - - OntarioOntarioOntarioOntarioMaterialMaterialMaterialMaterial TypeTypeTypeType ValueValueValueValue
TOLUENE (108-88-3) 20.0000 ppmTWA
Canada Canada Canada Canada - - - - QuebecQuebecQuebecQuebecMaterialMaterialMaterialMaterial TypeTypeTypeType ValueValueValueValue
TOLUENE (108-88-3) 50.0000 ppmTWA188.0000 mg/m3
Engineering controlsEngineering controlsEngineering controlsEngineering controls Good general ventilation (typically 10 air changes per hour) should be used. Ventilation ratesshould be matched to conditions. If applicable, use process enclosures, local exhaust ventilation,or other engineering controls to maintain airborne levels below recommended exposure limits. Ifexposure limits have not been established, maintain airborne levels to an acceptable level.Explosion proof exhaust ventilation should be used.
Personal protective equipmentPersonal protective equipmentPersonal protective equipmentPersonal protective equipmentEye / face protectionEye / face protectionEye / face protectionEye / face protection Chemical goggles and face shield are recommended.Skin protectionSkin protectionSkin protectionSkin protection Wear appropriate chemical resistant clothing. Wear appropriate chemical resistant gloves.Respiratory protectionRespiratory protectionRespiratory protectionRespiratory protection Respirator type: Chemical respirator with organic vapor cartridge and full facepiece. Use a
positive-pressure air-supplied respirator if there is any potential for an uncontrolled release,exposure levels are not known, or any other circumstances where air-purifying respirators maynot provide adequate protection.
GeneralGeneralGeneralGeneral Provide eyewash station and safety shower.
9999. . . . Physical & Chemical PropertiesPhysical & Chemical PropertiesPhysical & Chemical PropertiesPhysical & Chemical PropertiesAppearanceAppearanceAppearanceAppearance Clear.
Material name: TOLUENEMSDS ID: T3913 Version #: 02 Revision date: 08-30-2011
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ColorColorColorColor Colorless.
OdorOdorOdorOdor Aromatic. Sweet.
Odor thresholdOdor thresholdOdor thresholdOdor threshold Not available.
Physical statePhysical statePhysical statePhysical state Liquid.
FormFormFormForm Liquid.
pHpHpHpH Not available.
Melting pointMelting pointMelting pointMelting point -139 °F (-94.9 °C)
Freezing pointFreezing pointFreezing pointFreezing point -139 °F (-94.9 °C)
Boiling pointBoiling pointBoiling pointBoiling point 231.8 °F (110.6 °C)
Flash pointFlash pointFlash pointFlash point 39.2 °F (4 °C) Closed Cup
Evaporation rateEvaporation rateEvaporation rateEvaporation rate 2.24 BuAc
Flammability limits in air, upper,Flammability limits in air, upper,Flammability limits in air, upper,Flammability limits in air, upper,% by volume% by volume% by volume% by volume
7.1 %
Flammability limits in air, lower,Flammability limits in air, lower,Flammability limits in air, lower,Flammability limits in air, lower,% by volume% by volume% by volume% by volume
1.1 %
Vapor pressureVapor pressureVapor pressureVapor pressure 3.786 kPa at 25°C
Vapor densityVapor densityVapor densityVapor density 3.1
Specific gravitySpecific gravitySpecific gravitySpecific gravity 0.8636
Relative densityRelative densityRelative densityRelative density Not available.
Solubility (water)Solubility (water)Solubility (water)Solubility (water) 0.7 g/l at 74°F
Partition coefficientPartition coefficientPartition coefficientPartition coefficient(n-octanol/water)(n-octanol/water)(n-octanol/water)(n-octanol/water)
2.73
Auto-ignition temperatureAuto-ignition temperatureAuto-ignition temperatureAuto-ignition temperature 896 °F (480 °C)
Percent volatilePercent volatilePercent volatilePercent volatile 100 %
Molecular weightMolecular weightMolecular weightMolecular weight 92.14 g/mol
Molecular formulaMolecular formulaMolecular formulaMolecular formula C7-H8
10101010. . . . Chemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical stabilityChemical stabilityChemical stabilityChemical stability Stable under normal temperature conditions.Conditions to avoidConditions to avoidConditions to avoidConditions to avoid Heat, flames and sparks.Incompatible materialsIncompatible materialsIncompatible materialsIncompatible materials Strong oxidizing agents. Chlorine.Hazardous decompositionHazardous decompositionHazardous decompositionHazardous decompositionproductsproductsproductsproducts
At thermal decomposition temperatures, carbon monoxide and carbon dioxide.
Possibility of hazardousPossibility of hazardousPossibility of hazardousPossibility of hazardousreactionsreactionsreactionsreactions
Hazardous polymerization does not occur.
Toxicological dataToxicological dataToxicological dataToxicological data
11111111. . . . Toxicological InformationToxicological InformationToxicological InformationToxicological Information
ProductProductProductProduct Test ResultsTest ResultsTest ResultsTest ResultsAcute Dermal LD50 Rabbit: 12124 mg/kgTOLUENE (108-88-3)
Acute Inhalation LC50 Rat: 8000 ppm 4.00 Hours
Acute Oral LD50 Rat: 636 mg/kg
Acute effectsAcute effectsAcute effectsAcute effects Harmful if inhaled or absorbed through skin. Harmful or fatal if swallowed.
SensitizationSensitizationSensitizationSensitization Not a skin sensitizer.
Local effectsLocal effectsLocal effectsLocal effects Irritating to eyes, respiratory system and skin. High vapor concentrations may cause drowsinessand irritation of the eyes or respiratory tract.
Material name: TOLUENEMSDS ID: T3913 Version #: 02 Revision date: 08-30-2011
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Chronic effectsChronic effectsChronic effectsChronic effects Toluene: Concentrated, prolonged or deliberate inhalation may cause brain and nervous systemdamage. Prolonged and repeated exposure of pregnant animals (> 1500 ppm) have beenreported to cause adverse fetal developmental effects. Frequent or prolonged contact may defatand dry the skin, leading to discomfort and dermatitis.
CarcinogenicityCarcinogenicityCarcinogenicityCarcinogenicity This product is not considered to be a carcinogen by IARC, ACGIH, NTP, or OSHA.
IARC Monographs. Overall Evaluation of CarcinogenicityIARC Monographs. Overall Evaluation of CarcinogenicityIARC Monographs. Overall Evaluation of CarcinogenicityIARC Monographs. Overall Evaluation of CarcinogenicityTOLUENE (CAS 108-88-3) 3 Not classifiable as to carcinogenicity to humans.
Neurological effectsNeurological effectsNeurological effectsNeurological effects High vapor/aerosol concentrations (attainable only at elevated temperatures) may cause centralnervous system effects such as dizziness, drowsiness or headaches. Central and/or peripheralnervous system damage.
MutagenicityMutagenicityMutagenicityMutagenicity No data available to indicate product or any components present at greater than 0.1% aremutagenic or genotoxic.
Reproductive effectsReproductive effectsReproductive effectsReproductive effects Possible risk of harm to the unborn child.
TeratogenicityTeratogenicityTeratogenicityTeratogenicity Components in this product have been shown to cause birth defects and reproductive disorders inlaboratory animals.
Symptoms and targetSymptoms and targetSymptoms and targetSymptoms and targetorgansorgansorgansorgans
Irritation. Upper respiratory tract irritation. Drowsiness and dizziness. Birth defects.
EpidemiologyEpidemiologyEpidemiologyEpidemiology No epidemiological data is available for this product.
Ecotoxicological dataEcotoxicological dataEcotoxicological dataEcotoxicological data
12121212. . . . Ecological InformationEcological InformationEcological InformationEcological Information
ProductProductProductProduct Test ResultsTest ResultsTest ResultsTest Results
EC50 Water flea (Daphnia magna): 5.46 mg/l 48.00 hoursTOLUENE (108-88-3)LC50 Coho salmon,silver salmon (Oncorhynchus kisutch): 5.5mg/l 96.00 hoursLC50 Fathead minnow (Pimephales promelas): 12.6 mg/l 96.00hours
EcotoxicityEcotoxicityEcotoxicityEcotoxicity Toxic to aquatic life.
Environmental effectsEnvironmental effectsEnvironmental effectsEnvironmental effects Toxic to aquatic organisms. Bioaccumulation is unlikely to be significant because of the low watersolubility of this product. An environmental hazard cannot be excluded in the event ofunprofessional handling or disposal.
Persistence andPersistence andPersistence andPersistence anddegradabilitydegradabilitydegradabilitydegradability
Expected to be readily biodegradable.
Partition coefficientPartition coefficientPartition coefficientPartition coefficient 2.73
13131313. . . . Disposal ConsiderationsDisposal ConsiderationsDisposal ConsiderationsDisposal ConsiderationsDisposal instructionsDisposal instructionsDisposal instructionsDisposal instructions Dispose of this material and its container to hazardous or special waste collection point.
Incinerate the material under controlled conditions in an approved incinerator. All wastes must behandled in accordance with local, state and federal regulations.
Waste from residues / unusedWaste from residues / unusedWaste from residues / unusedWaste from residues / unusedproductsproductsproductsproducts
Dispose of in accordance with local regulations.
Contaminated packagingContaminated packagingContaminated packagingContaminated packaging Since emptied containers retain product residue, follow label warnings even after container isemptied. Residual vapors may explode on ignition; do not cut, drill, grind, or weld on or near thiscontainer. Offer rinsed packaging material to local recycling facilities.
14141414. . . . Transport InformationTransport InformationTransport InformationTransport InformationTDGTDGTDGTDG
TOLUENEProper shipping nameProper shipping nameProper shipping nameProper shipping name3Hazard classHazard classHazard classHazard classUN1294UN numberUN numberUN numberUN numberIIPacking groupPacking groupPacking groupPacking group
Material name: TOLUENEMSDS ID: T3913 Version #: 02 Revision date: 08-30-2011
MSDS CANADA
5 / 7
TDGTDGTDGTDG
15151515. . . . Regulatory InformationRegulatory InformationRegulatory InformationRegulatory InformationCanadian regulationsCanadian regulationsCanadian regulationsCanadian regulations This product has been classified in accordance with the hazard criteria of the CPR and the MSDS
contains all the information required by the CPR.WHMIS statusWHMIS statusWHMIS statusWHMIS status ControlledWHMIS classificationWHMIS classificationWHMIS classificationWHMIS classification B2 - Flammable/Combustible
D2A - Other Toxic Effects-VERY TOXICD2B - Other Toxic Effects-TOXIC
WHMIS labelingWHMIS labelingWHMIS labelingWHMIS labeling
Inventory statusInventory statusInventory statusInventory statusCountryCountryCountryCountry((((ssss) ) ) ) or regionor regionor regionor region Inventory nameInventory nameInventory nameInventory name On inventory On inventory On inventory On inventory ((((yesyesyesyes////nononono)*)*)*)*
YesAustralia Australian Inventory of Chemical Substances (AICS)YesCanada Domestic Substances List (DSL)NoCanada Non-Domestic Substances List (NDSL)
YesChina Inventory of Existing Chemical Substances in China (IECSC)YesEurope European Inventory of Existing Commercial Chemical
Substances (EINECS)NoEurope European List of Notified Chemical Substances (ELINCS)
YesJapan Inventory of Existing and New Chemical Substances (ENCS)YesKorea Existing Chemicals List (ECL)YesNew Zealand New Zealand InventoryYesPhilippines Philippine Inventory of Chemicals and Chemical Substances
(PICCS)YesUnited States & Puerto Rico Toxic Substances Control Act (TSCA) Inventory
*A "Yes" indicates that all components of this product comply with the inventory requirements administered by the governing country(s)
Saf-T-DataSaf-T-DataSaf-T-DataSaf-T-Data Health: 2 - Moderate (Life)Flammability: 3 - Severe (Flammable)Reactivity: 1 - SlightContact: 2 - Moderate (Life)Lab Protective Equip: DB - GOGGLES & SHIELD; LAB COAT & APRON; VENT HOOD; PROPERGLOVES; CLASS B EXTINGUISHERStorage Color Code: R - Red (Flammable)
16161616. . . . Other InformationOther InformationOther InformationOther InformationNFPA ratingsNFPA ratingsNFPA ratingsNFPA ratings Health: 2
Flammability: 3Instability: 0
Material name: TOLUENEMSDS ID: T3913 Version #: 02 Revision date: 08-30-2011
MSDS CANADA
6 / 7
DisclaimerDisclaimerDisclaimerDisclaimer THE INFORMATION PRESENTED IN THIS MATERIAL SAFETY DATA SHEET (MSDS/SDS)WAS PREPARED BY TECHNICAL PERSONNEL BASED ON DATA THAT THEY BELIEVE INTHEIR GOOD FAITH JUDGMENT IS ACCURATE. HOWEVER, THE INFORMATION PROVIDEDHEREIN IS PROVIDED “AS IS,” AND AVANTOR PERFORMANCE MATERIALS MAKES ANDGIVES NO REPRESENTATIONS OR WARRANTIES WHATSOEVER, AND EXPRESSLYDISCLAIMS ALL WARRANTIES REGARDING SUCH INFORMATION AND THE PRODUCT TOWHICH IT RELATES, WHETHER EXPRESS, IMPLIED, OR STATUTORY, INCLUDINGWITHOUT LIMITATION, WARRANTIES OF ACCURACY, COMPLETENESS,MERCHANTABILITY, NON-INFRINGEMENT, PERFORMANCE, SAFETY, SUITABILITY,STABILITY, AND FITNESS FOR A PARTICULAR PURPOSE, AND ANY WARRANTIES ARISINGFROM COURSE OF DEALING, COURSE OF PERFORMANCE, OR USAGE OF TRADE. THISMSDS/SDS IS INTENDED ONLY AS A GUIDE TO THE APPROPRIATE PRECAUTIONARYHANDLING OF THE MATERIAL BY A PROPERLY TRAINED PERSON USING THIS PRODUCT,AND IS NOT INTENDED TO BE COMPREHENSIVE AS TO THE MANNER AND CONDITIONSOF USE, HANDLING, STORAGE, OR DISPOSAL OF THE PRODUCT. INDIVIDUALSRECEIVING THIS MSDS/SDS MUST ALWAYS EXERCISE THEIR OWN INDEPENDENTJUDGMENT IN DETERMINING THE APPROPRIATENESS OF SUCH ISSUES. ACCORDINGLY,AVANTOR PERFORMANCE MATERIALS ASSUMES NO LIABILITY WHATSOEVER FOR THEUSE OF OR RELIANCE UPON THIS INFORMATION. NO SUGGESTIONS FOR USE AREINTENDED AS, AND NOTHING HEREIN SHALL BE CONSTRUED AS, A RECOMMENDATIONTO INFRINGE ANY EXISTING PATENTS OR TO VIOLATE ANY FEDERAL, STATE, LOCAL, ORFOREIGN LAWS. AVANTOR PERFORMANCE MATERIALS REMINDS YOU THAT IT IS YOURLEGAL DUTY TO MAKE ALL INFORMATION IN THIS MSDS/SDS AVAILABLE TO YOUREMPLOYEES.
Issue dateIssue dateIssue dateIssue date 08-30-2011This data sheet containsThis data sheet containsThis data sheet containsThis data sheet containschanges from the previouschanges from the previouschanges from the previouschanges from the previousversion in section(s):version in section(s):version in section(s):version in section(s):
Exposure Controls / Personal Protection: Respiratory protection
Material name: TOLUENEMSDS ID: T3913 Version #: 02 Revision date: 08-30-2011
MSDS CANADA
7 / 7
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Revision Date 01.03.2018 Version 1.2
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 19
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 803945
Product name Iron(III) chloride anhydrous for synthesis
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.
CAS-No. 7705-08-0
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Chemical for synthesis
For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * 8th Floor, Godrej One,
Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079
India * Tel: 0091 22 6210 9000
Responsible Department Quality Assurance * Merck Life Science Private Limited *
e-mail: [email protected] *
Tel : +91-2267863131-6
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 803945
Product name Iron(III) chloride anhydrous for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 19
1.4 Emergency telephone
number
Please contact the regional company representation in your country.
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
Classification (REGULATION (EC) No 1272/2008)
Corrosive to metals, Category 1, H290
Acute toxicity, Category 4, Oral, H302
Skin irritation, Category 2, H315
Serious eye damage, Category 1, H318
Skin sensitisation, Category 1, H317
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Hazard pictograms
Signal word
Danger
Hazard statements
H290 May be corrosive to metals.
H302 Harmful if swallowed.
H315 Causes skin irritation.
H317 May cause an allergic skin reaction.
H318 Causes serious eye damage.
Precautionary statements
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 803945
Product name Iron(III) chloride anhydrous for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 19
Prevention
P280 Wear protective gloves.
P280 Wear eye protection.
Response
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
P313 Get medical advice/ attention.
Reduced labelling (≤125 ml)
Hazard pictograms
Signal word
Danger
Hazard statements
H317 May cause an allergic skin reaction.
H318 Causes serious eye damage.
Precautionary statements
P280 Wear protective gloves.
P280 Wear eye protection.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing.
P313 Get medical advice/ attention.
Contains: iron(III) chloride, chromium(III) chloride, nickel(II) chloride
CAS-No. 7705-08-0
2.3 Other hazards
None known.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 803945
Product name Iron(III) chloride anhydrous for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 4 of 19
SECTION 3. Composition/information on ingredients
3.1 Substance
Formula FeCl₃ Cl₃Fe (Hill)
EC-No. 231-729-4
Molar mass 162.20 g/mol
Hazardous components (REGULATION (EC) No 1272/2008)
Chemical name (Concentration)
CAS-No. Registration number Classification
iron(III) chloride (>= 80 % - <= 100 % )
7705-08-0 *)
Corrosive to metals, Category 1, H290
Acute toxicity, Category 4, H302
Skin irritation, Category 2, H315
Serious eye damage, Category 1, H318
zinc chloride (< 0.25 % )
PBT/vPvB: Not applicable for inorganic substances
7646-85-7 *)
Acute toxicity, Category 4, H302
Skin corrosion, Category 1B, H314
Acute aquatic toxicity, Category 1, H400
Chronic aquatic toxicity, Category 1, H410
M-Factor: 1
*) A registration number is not available for this substance as the substance or its use are exempted from registration according to Article
2 REACH Regulation (EC) No 1907/2006, the annual tonnage does not require a registration or the registration is envisaged for a later
registration deadline.
For the full text of the H-Statements mentioned in this Section, see Section 16.
3.2 Mixture
Not applicable
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 803945
Product name Iron(III) chloride anhydrous for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 5 of 19
SECTION 4. First aid measures
4.1 Description of first aid measures
After inhalation: fresh air.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower. Consult a physician.
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove
contact lenses.
After swallowing: immediately make victim drink water (two glasses at most). Consult a
physician.
4.2 Most important symptoms and effects, both acute and delayed
Nausea, Vomiting
The following applies to soluble iron compounds: nausea and vomiting after swallowing. The
absorption of large quantities is followed by cardiovascular disorders. Toxic effect on liver and
kidneys.
Irritation and corrosion, Allergic reactions
Risk of serious damage to eyes.
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SECTION 5. Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Use extinguishing measures that are appropriate to local circumstances and the surrounding
environment.
Unsuitable extinguishing media
Water, Foam
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 803945
Product name Iron(III) chloride anhydrous for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 6 of 19
5.2 Special hazards arising from the substance or mixture
Not combustible.
May not get in touch with:
Water
Caution! in contact with water product releases:
hydrochloric acid
Ambient fire may liberate hazardous vapours.
Fire may cause evolution of:
Hydrogen chloride gas
5.3 Advice for firefighters
Special protective equipment for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.
Further information
Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing
water from contaminating surface water or the ground water system.
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact. Ensure
adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an
expert.
Advice for emergency responders:
Protective equipment see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 803945
Product name Iron(III) chloride anhydrous for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 7 of 19
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see
sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation
of dusts.
6.4 Reference to other sections
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handling
Keep workplace dry. Do not allow product to come into contact with water.
Observe label precautions.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and
face after working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Requirements for storage areas and containers
No metal containers.
Storage conditions
Tightly closed. Dry.
Recommended storage temperature see product label.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 803945
Product name Iron(III) chloride anhydrous for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 8 of 19
Contains no substances with occupational exposure limit values.
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Eye/face protection
Tightly fitting safety goggles
Hand protection
full contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
splash contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 741 Dermatril® L (full contact),
KCL 741 Dermatril® L (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 803945
Product name Iron(III) chloride anhydrous for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 9 of 19
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Other protective equipment
protective clothing
Respiratory protection
required when dusts are generated.
Recommended Filter type: Filter B-(P2)
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
Environmental exposure controls
Do not let product enter drains.
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
Form powder
Colour green
to
black
Odour stinging
Odour Threshold No information available.
pH 1
at 200 g/l
20 °C
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 803945
Product name Iron(III) chloride anhydrous for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 10 of 19
Melting point 306 °C
(decomposition)
Boiling point No information available.
Flash point does not flash
Evaporation rate No information available.
Flammability (solid, gas) The product is not flammable.
Lower explosion limit Not applicable
Upper explosion limit Not applicable
Vapour pressure 1 hPa
at 20 °C
Relative vapour density No information available.
Density 2.89 g/cm3
at 25 °C
Relative density No information available.
Water solubility 920 g/l
at 20 °C
Hydrolysis
Partition coefficient: n-
octanol/water
No information available.
Auto-ignition temperature No information available.
Decomposition temperature 306 °C
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 803945
Product name Iron(III) chloride anhydrous for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 11 of 19
Viscosity, dynamic Not applicable
Explosive properties Not classified as explosive.
Oxidizing properties Oxidizing potential
9.2 Other data
Sublimation point 304 °C
at 1,000 hPa
Ignition temperature not combustible
Bulk density ca.1,000 kg/m3
Viscosity, kinematic Not applicable
Corrosion May be corrosive to metals.
SECTION 10. Stability and reactivity
10.1 Reactivity
See section 10.3
10.2 Chemical stability
sublimable
sensitive to moisture
10.3 Possibility of hazardous reactions
Risk of explosion with:
Alkali metals, Ethylene oxide
Violent reactions possible with:
ALLYL CHLORIDE
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 803945
Product name Iron(III) chloride anhydrous for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 12 of 19
Aluminium, with, Heat
Generates dangerous gases or fumes in contact with:
Water
10.4 Conditions to avoid
Strong heating (decomposition).
Exposure to moisture
10.5 Incompatible materials
Copper, Light metals
Metals
10.6 Hazardous decomposition products
in the event of fire: See section 5.
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Acute oral toxicity
LD50 Rat: 316 mg/kg
(RTECS)
Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and
gastrointestinal tract., Nausea, Vomiting
Acute inhalation toxicity
Symptoms: Possible damages:, mucosal irritations
Acute dermal toxicity
LD50 Dermal Rat: > 2,000 mg/kg
(External MSDS)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 803945
Product name Iron(III) chloride anhydrous for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 13 of 19
Skin irritation
Rabbit
Result: irritating
(IUCLID)
Causes skin irritation.
Eye irritation
Rabbit
Result: Severe irritations
OECD Test Guideline 405
Causes serious eye damage.
Sensitisation
May cause an allergic skin reaction.
Germ cell mutagenicity
Genotoxicity in vivo
In vivo micronucleus test
Mouse
Result: negative
(External MSDS)
Genotoxicity in vitro
Ames test
Result: negative
Method: OECD Test Guideline 471
Mutagenicity (mammal cell test): micronucleus.
Result: negative
Method: OECD Test Guideline 487
Carcinogenicity
This information is not available.
Reproductive toxicity
This information is not available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 803945
Product name Iron(III) chloride anhydrous for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 14 of 19
Teratogenicity
This information is not available.
Specific target organ toxicity - single exposure
This information is not available.
Specific target organ toxicity - repeated exposure
This information is not available.
Repeated dose toxicity
Rat
male
Oral
98 d
daily
NOAEL: 277 mg/kg
OECD Test Guideline 408
Subchronic toxicity
Aspiration hazard
This information is not available.
11.2 Further information
Decomposition of the substance with tissue moisture.
The following applies to soluble iron compounds: nausea and vomiting after swallowing. The
absorption of large quantities is followed by cardiovascular disorders. Toxic effect on liver and
kidneys.
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
SECTION 12. Ecological information
12.1 Toxicity
Toxicity to fish
LC50 Lepomis macrochirus (Bluegill sunfish): 20.3 mg/l; 96 h
(External MSDS)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 803945
Product name Iron(III) chloride anhydrous for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 15 of 19
Toxicity to daphnia and other aquatic invertebrates
Immobilization EC50 Daphnia magna (Water flea): 9.6 mg/l; 48 h
OECD Test Guideline 202
Toxicity to algae
ErC50 Pseudokirchneriella subcapitata (green algae): 6.9 mg/l; 72 h
OECD Test Guideline 201
NOEC Pseudokirchneriella subcapitata (green algae): 2.4 mg/l; 72 h
OECD Test Guideline 201
Toxicity to fish (Chronic toxicity)
NOEC Pimephales promelas (fathead minnow): 0.33 mg/l; 33 d
(External MSDS)
Toxicity to daphnia and other aquatic invertebrates (Chronic toxicity)
NOEC Daphnia magna (Water flea): 0.7 mg/l; 21 d
(External MSDS)
12.2 Persistence and degradability
No information available.
12.3 Bioaccumulative potential
No information available.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.
12.6 Other adverse effects
Discharge into the environment must be avoided.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 803945
Product name Iron(III) chloride anhydrous for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 16 of 19
SECTION 13. Disposal considerations
Waste treatment methods
Waste material must be disposed of in accordance with the national and local regulations. Leave
chemicals in original containers. No mixing with other waste. Handle uncleaned containers like
the product itself.
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 UN number UN 1773
14.2 Proper shipping name FERRIC CHLORIDE, ANHYDROUS
14.3 Class 8
14.4 Packing group III
14.5 Environmentally hazardous --
14.6 Special precautions for
user
yes
Tunnel restriction code E
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)
14.1 UN number UN 1773
14.2 Proper shipping name FERRIC CHLORIDE, ANHYDROUS
14.3 Class 8
14.4 Packing group III
14.5 Environmentally hazardous --
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 803945
Product name Iron(III) chloride anhydrous for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 17 of 19
14.6 Special precautions for
user
no
Sea transport (IMDG)
14.1 UN number UN 1773
14.2 Proper shipping name FERRIC CHLORIDE, ANHYDROUS
14.3 Class 8
14.4 Packing group III
14.5 Environmentally hazardous --
14.6 Special precautions for
user
yes
EmS F-A S-B
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National legislation
Storage class 8B
15.2 Chemical safety assessment
For this product a chemical safety assessment was not carried out.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 803945
Product name Iron(III) chloride anhydrous for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 18 of 19
SECTION 16. Other information
Full text of H-Statements referred to under sections 2 and 3.
H290 May be corrosive to metals.
H302 Harmful if swallowed.
H314 Causes severe skin burns and eye damage.
H315 Causes skin irritation.
H317 May cause an allergic skin reaction.
H318 Causes serious eye damage.
H400 Very toxic to aquatic life.
H410 Very toxic to aquatic life with long lasting effects.
Training advice
Provide adequate information, instruction and training for operators.
Labelling
Hazard pictograms
Signal word
Danger
Hazard statements
H290 May be corrosive to metals.
H302 Harmful if swallowed.
H315 Causes skin irritation.
H317 May cause an allergic skin reaction.
H318 Causes serious eye damage.
Precautionary statements
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 803945
Product name Iron(III) chloride anhydrous for synthesis
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 19 of 19
Prevention
P280 Wear eye protection.
Response
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
P313 Get medical advice/ attention.
Contains: iron(III) chloride, chromium(III) chloride, nickel(II) chloride
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
MATERIAL SAFETY DATA SHEETMATERIAL SAFETY DATA SHEETMATERIAL SAFETY DATA SHEETMATERIAL SAFETY DATA SHEET
1111. . . . Product and Company IdentificationProduct and Company IdentificationProduct and Company IdentificationProduct and Company IdentificationMaterial nameMaterial nameMaterial nameMaterial name ZINC CHLORIDEZINC CHLORIDEZINC CHLORIDEZINC CHLORIDEVersion #Version #Version #Version # 02Revision dateRevision dateRevision dateRevision date 08-30-2011CAS #CAS #CAS #CAS # 7646-85-7Product CodesProduct CodesProduct CodesProduct Codes J.T.Baker: 4320, 4321, 4322, 4326J.T.Baker: 4320, 4321, 4322, 4326J.T.Baker: 4320, 4321, 4322, 4326J.T.Baker: 4320, 4321, 4322, 4326
Macron: 8772, 8780Macron: 8772, 8780Macron: 8772, 8780Macron: 8772, 8780Synonym(s)Synonym(s)Synonym(s)Synonym(s) Zinc Chloride, Zinc Dichloride, Zinc Butter
Customer ServiceCustomer ServiceCustomer ServiceCustomer Service 855-282-686724 Hour Emergency24 Hour Emergency24 Hour Emergency24 Hour Emergency 908-859-2151ChemtrecChemtrecChemtrecChemtrec 800-424-9300
ManufacturerManufacturerManufacturerManufacturerAddressAddressAddressAddress
Avantor Performance Materials, Inc.3477 Corporate Parkway
Center Valley, PA 18034US
Suite #200
2222. . . . Hazards IdentificationHazards IdentificationHazards IdentificationHazards IdentificationEmergency overviewEmergency overviewEmergency overviewEmergency overview DANGER
Corrosive. Causes severe skin and eye burns. Causes digestive tract burns. Harmful if inhaled orswallowed. Dust or vapor extremely irritating to the eyes and respiratory tract.
OSHA regulatory statusOSHA regulatory statusOSHA regulatory statusOSHA regulatory status This product is considered hazardous under 29 CFR 1910.1200 (Hazard Communication).
Potential health effectsPotential health effectsPotential health effectsPotential health effectsRoutes of exposureRoutes of exposureRoutes of exposureRoutes of exposure Ingestion. Inhalation. Skin contact. Eye contact.EyesEyesEyesEyes Corrosive. Causes severe eye burns. Dust or splashes from the mixture may cause permanent
eye damage.SkinSkinSkinSkin Corrosive. Causes severe skin burns.InhalationInhalationInhalationInhalation Harmful if inhaled. Corrosive. May cause damage to mucous membranes in nose, throat, lungs
and bronchial system.IngestionIngestionIngestionIngestion Harmful if swallowed. Corrosive. Ingestion may produce burns to the lips, oral cavity, upper
airway, esophagus and possibly the digestive tract.Target organsTarget organsTarget organsTarget organs Eyes. Skin. Lungs. Respiratory system. Liver.Chronic effectsChronic effectsChronic effectsChronic effects Corrosive. Prolonged contact causes serious tissue damage. May cause liver damage based on
animal data.Potential environmental effectsPotential environmental effectsPotential environmental effectsPotential environmental effects Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
ComponentsComponentsComponentsComponents CAS #CAS #CAS #CAS # PercentPercentPercentPercent
3333. . . . Composition Composition Composition Composition / / / / Information on IngredientsInformation on IngredientsInformation on IngredientsInformation on Ingredients
7646-85-7 97 - 100ZINC CHLORIDE
4444. . . . First Aid MeasuresFirst Aid MeasuresFirst Aid MeasuresFirst Aid MeasuresFirst aid proceduresFirst aid proceduresFirst aid proceduresFirst aid procedures
Eye contactEye contactEye contactEye contact Immediately flush with plenty of water for at least 15 minutes. If easy to do, remove contactlenses. Call a physician or poison control center immediately. In case of irritation from airborneexposure, move to fresh air. Get medical attention immediately.
Material name: ZINC CHLORIDEMSDS ID: Z2280 Version #: 02 Revision date: 08-30-2011
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Skin contactSkin contactSkin contactSkin contact Immediately flush with plenty of water for at least 15 minutes while removing contaminatedclothing and shoes. Call a physician or poison control center immediately. Wash clothingseparately before reuse. Destroy or thoroughly clean contaminated shoes.
InhalationInhalationInhalationInhalation Move to fresh air. If breathing stops, provide artificial respiration. If breathing is difficult, giveoxygen. Call a physician or poison control center immediately.
IngestionIngestionIngestionIngestion Call a physician or poison control center immediately. Do not induce vomiting. If vomiting occurs,the head should be kept low so that stomach vomit doesn't enter the lungs.
Notes to physicianNotes to physicianNotes to physicianNotes to physician Keep victim under observation. Treat symptomatically.General adviceGeneral adviceGeneral adviceGeneral advice In the case of accident or if you feel unwell, seek medical advice immediately (show the label
where possible). Show this safety data sheet to the doctor in attendance. Ensure that medicalpersonnel are aware of the material(s) involved, and take precautions to protect themselves.
5555. . . . Fire Fighting MeasuresFire Fighting MeasuresFire Fighting MeasuresFire Fighting MeasuresFlammable propertiesFlammable propertiesFlammable propertiesFlammable properties The product is not flammable. No unusual fire or explosion hazards noted.
Extinguishing mediaExtinguishing mediaExtinguishing mediaExtinguishing mediaSuitable extinguishingSuitable extinguishingSuitable extinguishingSuitable extinguishingmediamediamediamedia
Water spray. Carbon dioxide (CO2). Dry chemical powder. Foam.
Unsuitable extinguishingUnsuitable extinguishingUnsuitable extinguishingUnsuitable extinguishingmediamediamediamedia
None known.
Protection of firefightersProtection of firefightersProtection of firefightersProtection of firefightersSpecific hazards arisingSpecific hazards arisingSpecific hazards arisingSpecific hazards arisingfrom the chemicalfrom the chemicalfrom the chemicalfrom the chemical
Fire may produce irritating, corrosive and/or toxic gases.
Protective equipment andProtective equipment andProtective equipment andProtective equipment andprecautions for firefightersprecautions for firefightersprecautions for firefightersprecautions for firefighters
Use water spray to cool unopened containers. Self-contained breathing apparatus and fullprotective clothing must be worn in case of fire. Cool containers exposed to flames with water untilwell after the fire is out.
Special protective equipment forSpecial protective equipment forSpecial protective equipment forSpecial protective equipment forfire-fightersfire-fightersfire-fightersfire-fighters
Wear full protective clothing, including helmet, self-contained positive pressure or pressuredemand breathing apparatus, protective clothing and face mask. Wear self-contained breathingapparatus with a full facepiece operated in the positive pressure demand mode when fightingfires.
Specific methodsSpecific methodsSpecific methodsSpecific methods In the event of fire and/or explosion do not breathe fumes.
6666. . . . Accidental Release MeasuresAccidental Release MeasuresAccidental Release MeasuresAccidental Release MeasuresPersonal precautionsPersonal precautionsPersonal precautionsPersonal precautions Keep unnecessary personnel away. Wear appropriate protective equipment and clothing during
clean-up. Keep upwind. Keep out of low areas. Ventilate closed spaces before entering them.Local authorities should be advised if significant spillages cannot be contained.
Environmental precautionsEnvironmental precautionsEnvironmental precautionsEnvironmental precautions Do not allow to enter drains, sewers or watercourses. Prevent further leakage or spillage if safe todo so.
Methods for containmentMethods for containmentMethods for containmentMethods for containment Prevent entry into waterways, sewers, basements or confined areas. Stop leak if you can do sowithout risk. Dike the spilled material, where this is possible.
Methods for cleaning upMethods for cleaning upMethods for cleaning upMethods for cleaning up Avoid dust formation.
Large Spills: Sweep up or vacuum up spillage and collect in suitable container for disposal.
Small Spills: Sweep up and place in a clearly labeled container for chemical waste. Clean surfacethoroughly to remove residual contamination.
Never return spills in original containers for re-use. Clean up in accordance with all applicableregulations. Neutralize spill area and washings with soda ash or lime. Collect in anon-combustible container for prompt disposal.
7777. . . . Handling and StorageHandling and StorageHandling and StorageHandling and StorageHandlingHandlingHandlingHandling Wear appropriate personal protective equipment. Do not breathe dust or vapor. Do not get in
eyes, on skin, on clothing. Do not taste or swallow. Wash thoroughly after handling. Do not eat,drink or smoke when using the product. See Section 8 of the MSDS for Personal ProtectiveEquipment.
Material name: ZINC CHLORIDEMSDS ID: Z2280 Version #: 02 Revision date: 08-30-2011
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StorageStorageStorageStorage Keep tightly closed in a dry, cool and well-ventilated place.
ACGIHACGIHACGIHACGIH
8888. . . . Exposure Controls Exposure Controls Exposure Controls Exposure Controls / / / / Personal ProtectionPersonal ProtectionPersonal ProtectionPersonal Protection
MaterialMaterialMaterialMaterial TypeTypeTypeType ValueValueValueValue FormFormFormForm
ZINC CHLORIDE (7646-85-7) 2.0000 mg/m3 Fume.STEL1.0000 mg/m3 Fume.TWA
UUUU....SSSS. - . - . - . - OSHAOSHAOSHAOSHAOccupational exposure limitsOccupational exposure limitsOccupational exposure limitsOccupational exposure limits
MaterialMaterialMaterialMaterial TypeTypeTypeType ValueValueValueValue FormFormFormForm
ZINC CHLORIDE (7646-85-7) 1.0000 mg/m3 Fume.PEL
Engineering controlsEngineering controlsEngineering controlsEngineering controls Good general ventilation (typically 10 air changes per hour) should be used. Ventilation ratesshould be matched to conditions. If applicable, use process enclosures, local exhaust ventilation,or other engineering controls to maintain airborne levels below recommended exposure limits. Ifexposure limits have not been established, maintain airborne levels to an acceptable level.
Personal protective equipmentPersonal protective equipmentPersonal protective equipmentPersonal protective equipmentEye / face protectionEye / face protectionEye / face protectionEye / face protection Wear safety glasses with side shields (or goggles) and a face shield.Skin protectionSkin protectionSkin protectionSkin protection Wear appropriate chemical resistant clothing. Wear appropriate chemical resistant gloves.Respiratory protectionRespiratory protectionRespiratory protectionRespiratory protection If engineering controls do not maintain airborne concentrations below recommended exposure
limits (where applicable) or to an acceptable level (in countries where exposure limits have notbeen established), an approved respirator must be worn. Respirator type: High-efficiencyparticulate respirator with full facepiece.
General hygeineGeneral hygeineGeneral hygeineGeneral hygeineconsiderationsconsiderationsconsiderationsconsiderations
Provide eyewash station and safety shower. Always observe good personal hygiene measures,such as washing after handling the material and before eating, drinking, and/or smoking.Routinely wash work clothing and protective equipment to remove contaminants.
GeneralGeneralGeneralGeneral Wear chemical protective equipment that is specifically recommended by the manufacturer.Launder contaminated clothing before reuse.
9999. . . . Physical & Chemical PropertiesPhysical & Chemical PropertiesPhysical & Chemical PropertiesPhysical & Chemical PropertiesAppearanceAppearanceAppearanceAppearance Crystalline. Granular.
ColorColorColorColor White.
OdorOdorOdorOdor Odorless.
Odor thresholdOdor thresholdOdor thresholdOdor threshold Not available.
Physical statePhysical statePhysical statePhysical state Solid.
FormFormFormForm Crystalline. Granular.
pHpHpHpH 1 (6 M Solution)
Melting pointMelting pointMelting pointMelting point 554 °F (290 °C)
Freezing pointFreezing pointFreezing pointFreezing point 554 °F (290 °C)
Boiling pointBoiling pointBoiling pointBoiling point 1349.6 °F (732 °C)
Flash pointFlash pointFlash pointFlash point Not available.
Flammability limits in air, upper,Flammability limits in air, upper,Flammability limits in air, upper,Flammability limits in air, upper,% by volume% by volume% by volume% by volume
Not available.
Flammability limits in air, lower,Flammability limits in air, lower,Flammability limits in air, lower,Flammability limits in air, lower,% by volume% by volume% by volume% by volume
Not available.
Specific gravitySpecific gravitySpecific gravitySpecific gravity 2.907
Relative densityRelative densityRelative densityRelative density Not available.
Solubility (water)Solubility (water)Solubility (water)Solubility (water) 4350 g/l at 70°F
Partition coefficientPartition coefficientPartition coefficientPartition coefficient(n-octanol/water)(n-octanol/water)(n-octanol/water)(n-octanol/water)
Not available
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Auto-ignition temperatureAuto-ignition temperatureAuto-ignition temperatureAuto-ignition temperature Not available.
Molecular weightMolecular weightMolecular weightMolecular weight 136.3 g/mol
Molecular formulaMolecular formulaMolecular formulaMolecular formula Cl2-Zn
10101010. . . . Chemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical stabilityChemical stabilityChemical stabilityChemical stability Stable under normal temperature conditions.Conditions to avoidConditions to avoidConditions to avoidConditions to avoid Do not allow water to get into container because of reaction.Incompatible materialsIncompatible materialsIncompatible materialsIncompatible materials Strong oxidizing agents. Bases, alkalies (organic). Potassium. Moisture.Hazardous decompositionHazardous decompositionHazardous decompositionHazardous decompositionproductsproductsproductsproducts
Hydrogen chloride. Zinc oxide.
Possibility of hazardousPossibility of hazardousPossibility of hazardousPossibility of hazardousreactionsreactionsreactionsreactions
Hazardous polymerization does not occur.
Toxicological dataToxicological dataToxicological dataToxicological data
11111111. . . . Toxicological InformationToxicological InformationToxicological InformationToxicological Information
ProductProductProductProduct Test ResultsTest ResultsTest ResultsTest ResultsAcute Inhalation LC50 Rat: 1.975 mg/l 10.00 MinutesZINC CHLORIDE (7646-85-7)
Acute Oral LD50 Rat: 350 mg/kg
SensitizationSensitizationSensitizationSensitization Not a skin sensitizer.
Acute effectsAcute effectsAcute effectsAcute effects Harmful if inhaled or swallowed. Strongly corrosive. May cause deep tissue damage. Vapors arecorrosive. After some hours, injured persons may develop serious shortness of breath and lungedema.
Local effectsLocal effectsLocal effectsLocal effects Causes severe burns.
Chronic effectsChronic effectsChronic effectsChronic effects Corrosive. Prolonged contact causes serious tissue damage. May cause liver damage based onanimal data.
CarcinogenicityCarcinogenicityCarcinogenicityCarcinogenicity This product is not considered to be a carcinogen by IARC, ACGIH, NTP, or OSHA.
Skin corrosion/irritationSkin corrosion/irritationSkin corrosion/irritationSkin corrosion/irritation Corrosive to skin and eyes.
EpidemiologyEpidemiologyEpidemiologyEpidemiology No epidemiological data is available for this product.
MutagenicityMutagenicityMutagenicityMutagenicity No data available to indicate product or any components present at greater than 0.1% aremutagenic or genotoxic.
Neurological effectsNeurological effectsNeurological effectsNeurological effects No data available for this product.
Reproductive effectsReproductive effectsReproductive effectsReproductive effects Contains no ingredient listed as toxic to reproduction
Symptoms and targetSymptoms and targetSymptoms and targetSymptoms and targetorgansorgansorgansorgans
Corrosive effects.
Further informationFurther informationFurther informationFurther information Danger of very serious irreversible effects. Symptoms may be delayed.
Ecotoxicological dataEcotoxicological dataEcotoxicological dataEcotoxicological data
12121212. . . . Ecological InformationEcological InformationEcological InformationEcological Information
ProductProductProductProduct Test ResultsTest ResultsTest ResultsTest Results
EC50 Water flea (Daphnia magna): 0.1 mg/l 48.00 hoursZINC CHLORIDE (7646-85-7)LC50 Inland silverside (Menidia beryllina): 0.03 mg/l 96.00hours
EcotoxicityEcotoxicityEcotoxicityEcotoxicity Expected to be very toxic to aquatic organisms. May cause long-term adverse effects in theenvironment. The product may affect the acidity (pH-factor) in water with risk of harmful effects toaquatic organisms.
Persistence andPersistence andPersistence andPersistence anddegradabilitydegradabilitydegradabilitydegradability
The product is not readily biodegradable.
Partition coefficientPartition coefficientPartition coefficientPartition coefficient(n-octanol/water)(n-octanol/water)(n-octanol/water)(n-octanol/water)
Not available
Material name: ZINC CHLORIDEMSDS ID: Z2280 Version #: 02 Revision date: 08-30-2011
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13131313. . . . Disposal ConsiderationsDisposal ConsiderationsDisposal ConsiderationsDisposal ConsiderationsDisposal instructionsDisposal instructionsDisposal instructionsDisposal instructions Dispose of this material and its container to hazardous or special waste collection point.
Incinerate the material under controlled conditions in an approved incinerator. All wastes must behandled in accordance with local, state and federal regulations.
Contaminated packagingContaminated packagingContaminated packagingContaminated packaging Since emptied containers retain product residue, follow label warnings even after container isemptied. Offer rinsed packaging material to local recycling facilities.
14141414. . . . Transport InformationTransport InformationTransport InformationTransport InformationDOTDOTDOTDOT
Basic shipping requirements:Basic shipping requirements:Basic shipping requirements:Basic shipping requirements:UN2331UN numberUN numberUN numberUN numberZinc chloride, anhydrousProper shipping nameProper shipping nameProper shipping nameProper shipping name8Hazard classHazard classHazard classHazard classIIIPacking groupPacking groupPacking groupPacking group
Additional information:Additional information:Additional information:Additional information:IB8, IP3, T1, TP33Special provisionsSpecial provisionsSpecial provisionsSpecial provisions
Basic shipping requirements:Basic shipping requirements:Basic shipping requirements:Basic shipping requirements:8Labels requiredLabels requiredLabels requiredLabels required
Additional information:Additional information:Additional information:Additional information:NonePackaging exceptionsPackaging exceptionsPackaging exceptionsPackaging exceptions213Packaging non bulkPackaging non bulkPackaging non bulkPackaging non bulk240Packaging bulkPackaging bulkPackaging bulkPackaging bulk1000Reportable quantityReportable quantityReportable quantityReportable quantity154ERG numberERG numberERG numberERG number
IATAIATAIATAIATABasic shipping requirements:Basic shipping requirements:Basic shipping requirements:Basic shipping requirements:
2331UN numberUN numberUN numberUN numberZinc chloride, anhydrousProper shipping nameProper shipping nameProper shipping nameProper shipping name8Hazard classHazard classHazard classHazard classIIIPacking groupPacking groupPacking groupPacking group
Additional information:Additional information:Additional information:Additional information:8LERG codeERG codeERG codeERG code
IMDGIMDGIMDGIMDGBasic shipping requirements:Basic shipping requirements:Basic shipping requirements:Basic shipping requirements:
2331UN numberUN numberUN numberUN numberZINC CHLORIDE, ANHYDROUSProper shipping nameProper shipping nameProper shipping nameProper shipping name8Hazard classHazard classHazard classHazard classIIIPacking groupPacking groupPacking groupPacking group
DOTDOTDOTDOT IATAIATAIATAIATA IMDGIMDGIMDGIMDG
15151515. . . . Regulatory InformationRegulatory InformationRegulatory InformationRegulatory InformationUS federal regulationsUS federal regulationsUS federal regulationsUS federal regulations This product is a "Hazardous Chemical" as defined by the OSHA Hazard Communication
Standard, 29 CFR 1910.1200.All components are on the U.S. EPA TSCA Inventory List.
Material name: ZINC CHLORIDEMSDS ID: Z2280 Version #: 02 Revision date: 08-30-2011
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US EPCRA (SARA Title III) Section 313 - Toxic Chemical: De minimis concentrationUS EPCRA (SARA Title III) Section 313 - Toxic Chemical: De minimis concentrationUS EPCRA (SARA Title III) Section 313 - Toxic Chemical: De minimis concentrationUS EPCRA (SARA Title III) Section 313 - Toxic Chemical: De minimis concentrationZINC CHLORIDE (CAS 7646-85-7) 1.0 % N982
US EPCRA (SARA Title III) Section 313 - Toxic Chemical: Listed substanceUS EPCRA (SARA Title III) Section 313 - Toxic Chemical: Listed substanceUS EPCRA (SARA Title III) Section 313 - Toxic Chemical: Listed substanceUS EPCRA (SARA Title III) Section 313 - Toxic Chemical: Listed substanceZINC CHLORIDE (CAS 7646-85-7) Listed. N982
CERCLA (Superfund) reportable quantityCERCLA (Superfund) reportable quantityCERCLA (Superfund) reportable quantityCERCLA (Superfund) reportable quantityZINC CHLORIDE: 1000.0000
Superfund Amendments and Reauthorization Act of 1986 (SARA)Superfund Amendments and Reauthorization Act of 1986 (SARA)Superfund Amendments and Reauthorization Act of 1986 (SARA)Superfund Amendments and Reauthorization Act of 1986 (SARA)Hazard categoriesHazard categoriesHazard categoriesHazard categories Immediate Hazard - Yes
Delayed Hazard - YesFire Hazard - NoPressure Hazard - NoReactivity Hazard - No
Section 311 hazardousSection 311 hazardousSection 311 hazardousSection 311 hazardouschemicalchemicalchemicalchemical
Yes
Clean Water Act (CWA)Clean Water Act (CWA)Clean Water Act (CWA)Clean Water Act (CWA) Hazardous substancePriority pollutantToxic pollutant
Inventory statusInventory statusInventory statusInventory statusCountryCountryCountryCountry((((ssss) ) ) ) or regionor regionor regionor region Inventory nameInventory nameInventory nameInventory name On inventory On inventory On inventory On inventory ((((yesyesyesyes////nononono)*)*)*)*
YesAustralia Australian Inventory of Chemical Substances (AICS)YesCanada Domestic Substances List (DSL)NoCanada Non-Domestic Substances List (NDSL)
YesChina Inventory of Existing Chemical Substances in China (IECSC)YesEurope European Inventory of Existing Commercial Chemical
Substances (EINECS)NoEurope European List of Notified Chemical Substances (ELINCS)
YesJapan Inventory of Existing and New Chemical Substances (ENCS)YesKorea Existing Chemicals List (ECL)YesNew Zealand New Zealand InventoryYesPhilippines Philippine Inventory of Chemicals and Chemical Substances
(PICCS)YesUnited States & Puerto Rico Toxic Substances Control Act (TSCA) Inventory
*A "Yes" indicates that all components of this product comply with the inventory requirements administered by the governing country(s)
State regulationsState regulationsState regulationsState regulations This product does not contain a chemical known to the State of California to cause cancer, birthdefects or other reproductive harm.
US - New Jersey Community RTK (EHS Survey): Reportable thresholdUS - New Jersey Community RTK (EHS Survey): Reportable thresholdUS - New Jersey Community RTK (EHS Survey): Reportable thresholdUS - New Jersey Community RTK (EHS Survey): Reportable thresholdZINC CHLORIDE (CAS 7646-85-7) 500 LBS
US - Pennsylvania RTK - Hazardous Substances: Listed substanceUS - Pennsylvania RTK - Hazardous Substances: Listed substanceUS - Pennsylvania RTK - Hazardous Substances: Listed substanceUS - Pennsylvania RTK - Hazardous Substances: Listed substanceZINC CHLORIDE (CAS 7646-85-7) Listed.
Saf-T-DataSaf-T-DataSaf-T-DataSaf-T-Data Health: 3 - Severe (Life)Flammability: 0 - NoneReactivity: 1 - SlightContact: 3 - Severe (Corrosive)Lab Protective Equip: D - GOGGLES & SHIELD; LAB COAT & APRON; VENT HOOD; PROPERGLOVESStorage Color Code: W - White (Corrosive)
16161616. . . . Labeling InfoLabeling InfoLabeling InfoLabeling InfoLabel Hazard WarningLabel Hazard WarningLabel Hazard WarningLabel Hazard Warning DANGER
Corrosive. Causes severe skin and eye burns. Causes digestive tract burns. Harmful if inhaled orswallowed. Dust or vapor extremely irritating to the eyes and respiratory tract.
Material name: ZINC CHLORIDEMSDS ID: Z2280 Version #: 02 Revision date: 08-30-2011
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Label PrecautionsLabel PrecautionsLabel PrecautionsLabel Precautions Do not breathe dust. Do not get in eyes, on skin, or on clothing. Use only with adequateventilation. Keep container closed. Wash thoroughly after handling.
Label First AidLabel First AidLabel First AidLabel First Aid Immediately flush eyes with plenty of water for at least 15 minutes. Immediately flush skin withplenty of water. If gas/fume/vapor/dust/mist from the material is inhaled, remove the affectedperson immediately to fresh air. Get medical attention immediately. IF SWALLOWED:Immediately call a POISON CENTER or doctor/physician. Do not induce vomiting without advicefrom poison control center. If vomiting occurs, keep head low so that stomach content doesn't getinto the lungs. Do not use mouth-to-mouth method if victim ingested the substance.
17171717. . . . Other InformationOther InformationOther InformationOther InformationNFPA ratingsNFPA ratingsNFPA ratingsNFPA ratings Health: 3
Flammability: 0Instability: 0
DisclaimerDisclaimerDisclaimerDisclaimer THE INFORMATION PRESENTED IN THIS MATERIAL SAFETY DATA SHEET (MSDS/SDS)WAS PREPARED BY TECHNICAL PERSONNEL BASED ON DATA THAT THEY BELIEVE INTHEIR GOOD FAITH JUDGMENT IS ACCURATE. HOWEVER, THE INFORMATION PROVIDEDHEREIN IS PROVIDED “AS IS,” AND AVANTOR PERFORMANCE MATERIALS MAKES ANDGIVES NO REPRESENTATIONS OR WARRANTIES WHATSOEVER, AND EXPRESSLYDISCLAIMS ALL WARRANTIES REGARDING SUCH INFORMATION AND THE PRODUCT TOWHICH IT RELATES, WHETHER EXPRESS, IMPLIED, OR STATUTORY, INCLUDINGWITHOUT LIMITATION, WARRANTIES OF ACCURACY, COMPLETENESS,MERCHANTABILITY, NON-INFRINGEMENT, PERFORMANCE, SAFETY, SUITABILITY,STABILITY, AND FITNESS FOR A PARTICULAR PURPOSE, AND ANY WARRANTIES ARISINGFROM COURSE OF DEALING, COURSE OF PERFORMANCE, OR USAGE OF TRADE. THISMSDS/SDS IS INTENDED ONLY AS A GUIDE TO THE APPROPRIATE PRECAUTIONARYHANDLING OF THE MATERIAL BY A PROPERLY TRAINED PERSON USING THIS PRODUCT,AND IS NOT INTENDED TO BE COMPREHENSIVE AS TO THE MANNER AND CONDITIONSOF USE, HANDLING, STORAGE, OR DISPOSAL OF THE PRODUCT. INDIVIDUALSRECEIVING THIS MSDS/SDS MUST ALWAYS EXERCISE THEIR OWN INDEPENDENTJUDGMENT IN DETERMINING THE APPROPRIATENESS OF SUCH ISSUES. ACCORDINGLY,AVANTOR PERFORMANCE MATERIALS ASSUMES NO LIABILITY WHATSOEVER FOR THEUSE OF OR RELIANCE UPON THIS INFORMATION. NO SUGGESTIONS FOR USE AREINTENDED AS, AND NOTHING HEREIN SHALL BE CONSTRUED AS, A RECOMMENDATIONTO INFRINGE ANY EXISTING PATENTS OR TO VIOLATE ANY FEDERAL, STATE, LOCAL, ORFOREIGN LAWS. AVANTOR PERFORMANCE MATERIALS REMINDS YOU THAT IT IS YOURLEGAL DUTY TO MAKE ALL INFORMATION IN THIS MSDS/SDS AVAILABLE TO YOUREMPLOYEES.
Issue dateIssue dateIssue dateIssue date 08-30-2011
Material name: ZINC CHLORIDEMSDS ID: Z2280 Version #: 02 Revision date: 08-30-2011
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Material Safety Data Sheet
1. PRODUCT AND COMPANY IDENTIFICATION
Product Name Calcium chloride dihydrate Cat No. BP510-100; BP510-250; BP510-500; C69-50; C69-500; C69-500LC; C70-
500; C79-3; C79-3LC; C79-500 Synonyms (Crystals/Powder/Granules/USP/FCC/EP/Certified ACS) Recommended Use Laboratory chemicals
2. HAZARDS IDENTIFICATION
Target Organs Eyes Potential Health Effects Acute Effects Principle Routes of Exposure Eyes Irritating to eyes. Skin May cause irritation. Inhalation May cause irritation of respiratory tract. May be harmful if inhaled. Ingestion May be harmful if swallowed. Ingestion may cause gastrointestinal irritation, nausea, vomiting
and diarrhea. Chronic Effects None known. See Section 11 for additional Toxicological information. Aggravated Medical Conditions No information available.
_____________________________________________________________________________________________
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Revision Number 1
Irritating to eyes. May cause skin and respiratory tract irritation. Hygroscopic.
Creation Date 14-Aug-2009 Revision Date 22-Sep-2009
CompanyFisher ScientificOne Reagent LaneFair Lawn, NJ 07410Tel: (201) 796-7100
WARNING!
Emergency Telephone NumberCHEMTREC®, Inside the USA: 800-424-9300CHEMTREC®, Outside the USA: 703-527-3887
Emergency Overview
odor odorlessAppearance Beige - White Physical State Solid
_____________________________________________________________________________________________
3. COMPOSITION/INFORMATION ON INGREDIENTS
Haz/Non-haz
Component CAS-No Weight %Calcium chloride, dihydrate 10035-04-8 >95
Calcium chloride 10043-52-4 -
4. FIRST AID MEASURES
Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Obtain
medical attention. Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Get medical attention
immediately if symptoms occur.. Inhalation Move to fresh air. If breathing is difficult, give oxygen. Get medical attention immediately if
symptoms occur. Ingestion Do not induce vomiting. Obtain medical attention. Notes to Physician Treat symptomatically.
5. FIRE-FIGHTING MEASURES
Flash Point No information available. Method No information available. Autoignition Temperature No information available.Explosion Limits Upper No data available Lower No data available Suitable Extinguishing Media Substance is nonflammable; use agent most appropriate to
extinguish surrounding fire.. Unsuitable Extinguishing Media No information available. Hazardous Combustion Products No information available. Sensitivity to mechanical impact No information available. Sensitivity to static discharge No information available. Specific Hazards Arising from the ChemicalNon-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Protective Equipment and Precautions for FirefightersAs in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear.
6. ACCIDENTAL RELEASE MEASURES
Personal Precautions Ensure adequate ventilation. Use personal protective equipment. Avoid dust formation.
_____________________________________________________________________________________________
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Flammability 0 Instability 1 Physical hazards N/A
Thermo Fisher Scientific - Calcium chloride dihydrate
NFPA
Revision Date 22-Sep-2009
Health 2
_____________________________________________________________________________________________ Environmental Precautions Should not be released into the environment. Methods for Containment and Clean Up
Sweep up or vacuum up spillage and collect in suitable container for disposal. Avoid dust formation.
7. HANDLING AND STORAGE
Handling Wear personal protective equipment. Ensure adequate ventilation. Do not get in eyes, on skin,
or on clothing. Avoid ingestion and inhalation. Avoid dust formation. Storage Keep containers tightly closed in a dry, cool and well-ventilated place.
8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering Measures Ensure that eyewash stations and safety showers are close to the workstation location. Ensure
adequate ventilation, especially in confined areas. Exposure Guidelines
Component Quebec Mexico OEL (TWA) Ontario TWAEVCalcium chloride TWA: 5 mg/m3
NIOSH IDLH: Immediately Dangerous to Life or Health Personal Protective Equipment Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's
eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure. Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN
149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
9. PHYSICAL AND CHEMICAL PROPERTIES
Physical State SolidAppearance Beige - Whiteodor odorlessOdor Threshold No information available.pH 4.5-6.5 100 g/l aq. sol. Vapor Pressure No information available.Vapor Density No information available.Viscosity No information available.Boiling Point/Range No information available.Melting Point/Range 175°C / 347°FDecomposition temperature No information available.Flash Point No information available.Evaporation Rate No information available.Specific Gravity 0.830Solubility Soluble in waterlog Pow No data availableMolecular Weight 147.02Molecular Formula Ca Cl2 . 2 H2 O
_____________________________________________________________________________________________
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Revision Date 22-Sep-2009Thermo Fisher Scientific - Calcium chloride dihydrate
_____________________________________________________________________________________________
10. STABILITY AND REACTIVITY
Stability Hygroscopic. Conditions to Avoid Incompatible products. Excess heat. Avoid dust formation.
Exposure to moist air or water. Incompatible Materials Strong oxidizing agents Hazardous Decomposition Products Hydrogen chloride gas Hazardous Polymerization Hazardous polymerization does not occur. Hazardous Reactions . None under normal processing..
11. TOXICOLOGICAL INFORMATION
Acute Toxicity
Component Information
Component LD50 Oral LD50 Dermal LC50 InhalationCalcium chloride 1000 mg/kg ( Rat ) 2630 mg/kg ( Rat ) Not listed
Irritation Irritating to eyes Toxicologically Synergistic Products
No information available.
Chronic Toxicity Carcinogenicity There are no known carcinogenic chemicals in this product
Sensitization No information available. Mutagenic Effects No information available. Reproductive Effects No information available. Developmental Effects No information available. Teratogenicity No information available. Other Adverse Effects See actual entry in RTECS for complete information. Endocrine Disruptor Information No information available
12. ECOLOGICAL INFORMATION
_____________________________________________________________________________________________
Page 4 / 7
Revision Date 22-Sep-2009Thermo Fisher Scientific - Calcium chloride dihydrate
_____________________________________________________________________________________________
12. ECOLOGICAL INFORMATIONEcotoxicityDo not empty into drains.
Component Freshwater Algae Freshwater Fish Microtox Water FleaCalcium chloride, dihydrate Not listed Lepomis macrochirus: LC50:
10650 mg/L/96hNot listed EC50: 3005 mg/L/48h
Calcium chloride Not listed Lepomis macrochirus: LC50: 10650 mg/L/96h
Not listed EC50: 52 mg/L/48h
Persistence and Degradability No information available Bioaccumulation/ Accumulation No information available Mobility .
Component log PowCalcium chloride, dihydrate 0.05
13. DISPOSAL CONSIDERATIONS
Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a
hazardous waste. Chemical waste generators must also consult local, regional, and national hazardous waste regulations to ensure complete and accurate classification.
14. TRANSPORT INFORMATION
DOT Not regulated
TDG Not regulated
IATA Not regulated
IMDG/IMO Not regulated
15. REGULATORY INFORMATION
International Inventories
Component TSCA DSL NDSL EINECS ELINCS NLP PICCS ENCS AICS CHINA KECL Calcium chloride, dihydrate - - - - - X X X X -
Calcium chloride X X - 233-140-8
- X X X X KE-04496
X Legend:
_____________________________________________________________________________________________
Page 5 / 7
Thermo Fisher Scientific - Calcium chloride dihydrate Revision Date 22-Sep-2009
_____________________________________________________________________________________________ X - Listed E - Indicates a substance that is the subject of a Section 5(e) Consent order under TSCA. F - Indicates a substance that is the subject of a Section 5(f) Rule under TSCA. N - Indicates a polymeric substance containing no free-radical initiator in its inventory name but is considered to cover the designated polymer made with any free-radical initiator regardless of the amount used. P - Indicates a commenced PMN substance R - Indicates a substance that is the subject of a Section 6 risk management rule under TSCA. S - Indicates a substance that is identified in a proposed or final Significant New Use Rule T - Indicates a substance that is the subject of a Section 4 test rule under TSCA. XU - Indicates a substance exempt from reporting under the Inventory Update Rule, i.e. Partial Updating of the TSCA Inventory Data Base Production and Site Reports (40 CFR 710(B). Y1 - Indicates an exempt polymer that has a number-average molecular weight of 1,000 or greater. Y2 - Indicates an exempt polymer that is a polyester and is made only from reactants included in a specified list of low concern reactants that comprises one of the eligibility criteria for the exemption rule.
U.S. Federal Regulations TSCA 12(b) Not applicable SARA 313Not applicable
SARA 311/312 Hazardous Categorization Acute Health Hazard Yes Chronic Health Hazard No Fire Hazard No Sudden Release of Pressure Hazard No Reactive Hazard No Clean Water Act Not applicable
Clean Air Act Not applicable OSHA Not applicable CERCLA Not Applicable California Proposition 65 This product does not contain any Proposition 65 chemicals.
State Right-to-KnowNot applicable U.S. Department of Transportation Reportable Quantity (RQ): NDOT Marine Pollutant NDOT Severe Marine Pollutant N U.S. Department of Homeland Security This product does not contain any DHS chemicals. Other International Regulations
_____________________________________________________________________________________________
Page 6 / 7
Thermo Fisher Scientific - Calcium chloride dihydrate Revision Date 22-Sep-2009
_____________________________________________________________________________________________ Mexico - Grade No information available Canada This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all the information required by the CPR. WHMIS Hazard ClassD2B Toxic materials
16. OTHER INFORMATION
Prepared By Regulatory Affairs Thermo Fisher Scientific
Tel: (412) 490-8929 Creation Date 14-Aug-2009 Print Date 22-Sep-2009 Revision Summary "***", and red text indicates revision Disclaimer The information provided on this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered as a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other material or in any process, unless specified in the text.
End of MSDS
_____________________________________________________________________________________________
Page 7 / 7
Thermo Fisher Scientific - Calcium chloride dihydrate Revision Date 22-Sep-2009
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006
Revision Date 14.08.2015 Version 1.2
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 10
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 113136
Product name Hydrochloric acid c(HCl) = 0.357 mol/l (1/2.8 N) Titripur®
REACH Registration Number This product is a mixture. REACH Registration Number see section 3.
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Reagent for analysis
For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * 8th Floor, Godrej One,
Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079
India * Tel: 0091 22 6210 9000
Responsible Department Quality Assurance * Merck Life Science Private Limited *
e-mail: [email protected] *
Tel : +91-2267863131-6
1.4 Emergency telephone
number
Please contact the regional company representation in your country.
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
Classification (REGULATION (EC) No 1272/2008)
Corrosive to metals, Category 1, H290
For the full text of the H-Statements mentioned in this Section, see Section 16.
Classification (67/548/EEC or 1999/45/EC)In accordance with EC directives or respective national laws, the
product does not need to be classified nor labelled.
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Hazard pictograms
Signal wordWarning
Hazard statementsH290 May be corrosive to metals.
2.3 Other hazards
None known.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 113136
Product name Hydrochloric acid c(HCl) = 0.357 mol/l (1/2.8 N) Titripur®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 10
SECTION 3. Composition/information on ingredients
Chemical nature Aqueous solution
3.1 Substance
Not applicable
3.2 Mixture
Hazardous components (REGULATION (EC) No 1272/2008)
Chemical Name (Concentration) CAS-No. Registration number Classification
Hydrochloric Acid (>= 1 % - < 5 % ) Substance does not meet the criteria for PBT or vPvB according to Regulation (EC) No 1907/2006, Annex XIII.
7647-01-0 *)
Corrosive to metals, Category 1, H290
Skin corrosion, Category 1B, H314
Specific target organ toxicity - single exposure, Category 3, H335
*) A registration number is not available for this substance as the substance or its use are exempted from registration according to Article
2 REACH Regulation (EC) No 1907/2006, the annual tonnage does not require a registration or the registration is envisaged for a later
registration deadline.
For the full text of the H-Statements mentioned in this Section, see Section 16.
Hazardous components (1999/45/EC)
Chemical Name (Concentration) CAS-No. Classification
Hydrochloric Acid (>= 1 % - < 5 % ) 7647-01-0 C, Corrosive; R34
Xi, Irritant; R37
For the full text of the R-phrases mentioned in this Section, see Section 16.
SECTION 4. First aid measures
4.1 Description of first aid measures
After inhalation: fresh air.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower.
After eye contact: rinse out with plenty of water. Call in ophthalmologist.
After swallowing: make victim drink water (two glasses at most). Consult doctor if feeling unwell.
4.2 Most important symptoms and effects, both acute and delayed
irritant effects
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SECTION 5. Firefighting measures
5.1 Extinguishing media
Suitable extinguishing mediaUse extinguishing measures that are appropriate to local circumstances and the surrounding
environment.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 113136
Product name Hydrochloric acid c(HCl) = 0.357 mol/l (1/2.8 N) Titripur®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 10
Unsuitable extinguishing mediaFor this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Not combustible.
Ambient fire may liberate hazardous vapours.
Fire may cause evolution of:
Hydrogen chloride gas
5.3 Advice for firefighters
Special protective equipment for firefightersStay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.
Further informationSuppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing
water from contaminating surface water or the ground water system.
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid substance contact. Do not breathe vapours,
aerosols. Evacuate the danger area, observe emergency procedures, consult an expert.
Advice for emergency responders: Protective equipment see section 8.
6.2 Environmental precautions
Do not empty into drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills.
Observe possible material restrictions (see sections 7 and 10).
Take up with liquid-absorbent and neutralising material (e.g. Chemizorb® H⁺, Merck Art. No.
101595). Dispose of properly. Clean up affected area.
6.4 Reference to other sections
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handlingObserve label precautions.
Cannot be stored indefinitely.
Hygiene measuresChange contaminated clothing. Preventive skin protection recommended. Wash hands after
working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Requirements for storage areas and containersNo metal containers.
Storage conditionsTightly closed.
Recommended storage temperature see product label.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 113136
Product name Hydrochloric acid c(HCl) = 0.357 mol/l (1/2.8 N) Titripur®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 4 of 10
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
Hydrochloric Acid (7647-01-0)IN OEL Ceiling Limit Value: 5 ppm
7 mg/m³
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Eye/face protectionSafety glasses
Hand protection
full contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
splash contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 741 Dermatril® L (full contact),
KCL 741 Dermatril® L (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Other protective equipmentprotective clothing
Respiratory protectionrequired when vapours/aerosols are generated.
Recommended Filter type: filter E-(P2)
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 113136
Product name Hydrochloric acid c(HCl) = 0.357 mol/l (1/2.8 N) Titripur®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 5 of 10
Environmental exposure controls
Do not empty into drains.
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
Form liquid
Colour colourless
Odour odourless
Odour Threshold No information available.
pH ca. 1.2
at 20 °C
Melting point No information available.
Boiling point No information available.
Flash point No information available.
Evaporation rate No information available.
Flammability (solid, gas) No information available.
Lower explosion limit No information available.
Upper explosion limit No information available.
Vapour pressure No information available.
Relative vapour density No information available.
Density ca.1.01 g/cm3
at 20 °C
Relative density No information available.
Water solubility at 20 °C
soluble
Partition coefficient: n-
octanol/water
No information available.
Auto-ignition temperature No information available.
Decomposition temperature No information available.
Viscosity, dynamic No information available.
Explosive properties Not classified as explosive.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 113136
Product name Hydrochloric acid c(HCl) = 0.357 mol/l (1/2.8 N) Titripur®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 6 of 10
Oxidizing properties none
9.2 Other data
Ignition temperature Not applicable
Corrosion May be corrosive to metals.
SECTION 10. Stability and reactivity
10.1 Reactivity
See section 10.3
10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.3 Possibility of hazardous reactions
Generates dangerous gases or fumes in contact with:
Metals
Violent reactions possible with:
The generally known reaction partners of water.
10.4 Conditions to avoid
no information available
10.5 Incompatible materials
Metals, metal alloys
10.6 Hazardous decomposition products
in the event of fire: See section 5.
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Mixture
Acute oral toxicityThis information is not available.
Acute inhalation toxicityThis information is not available.
Acute dermal toxicityThis information is not available.
Skin irritation
Possible damages: slight irritation
Eye irritation
Possible damages: slight irritation
SensitisationThis information is not available.
Germ cell mutagenicityThis information is not available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 113136
Product name Hydrochloric acid c(HCl) = 0.357 mol/l (1/2.8 N) Titripur®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 7 of 10
CarcinogenicityThis information is not available.
Reproductive toxicityThis information is not available.
TeratogenicityThis information is not available.
Specific target organ toxicity - single exposureThe substance or mixture is not classified as specific target organ toxicant, single exposure.
Specific target organ toxicity - repeated exposureThe substance or mixture is not classified as specific target organ toxicant, repeated exposure.
Aspiration hazardBased on available data the classification criteria are not met.
11.2 Further information
However, when the product is handled appropriately, hazardous effects are unlikely to occur.
Handle in accordance with good industrial hygiene and safety practice.
Components
Hydrochloric Acid
Skin irritationRabbit
Result: Corrosive
OECD Test Guideline 404
Eye irritationRabbit
Result: Irreversible effects on the eye
OECD Test Guideline 405
SensitisationMaximisation Test (GPMT) Guinea pig
Result: Does not cause skin sensitisation.
Method: OECD Test Guideline 406
SECTION 12. Ecological information
Mixture
12.1 Toxicity
No information available.
12.2 Persistence and degradability
No information available.
12.3 Bioaccumulative potential
No information available.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
Substance(s) in the mixture do(es) not meet the criteria for PBT or vPvB according to Regulation
(EC) No 1907/2006, Annex XIII, or a PBT/vPvB assessment was not conducted.
12.6 Other adverse effects
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 113136
Product name Hydrochloric acid c(HCl) = 0.357 mol/l (1/2.8 N) Titripur®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 8 of 10
Additional ecological informationNo ecological problems are to be expected when the product is handled and used with due care
and attention.
Components
Hydrochloric Acid
Substance does not meet the criteria for PBT or vPvB according to Regulation (EC) No 1907/2006, Annex XIII.
SECTION 13. Disposal considerations
Waste treatment methodsWaste material must be disposed of in accordance with the national and local regulations. Leave
chemicals in original containers. No mixing with other waste. Handle uncleaned containers like
the product itself.
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 UN number UN 1789
14.2 Proper shipping name HYDROCHLORIC ACID
14.3 Class 8
14.4 Packing group III
14.5 Environmentally hazardous --
14.6 Special precautions for
user
yes
Tunnel restriction code E
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)
14.1 UN number UN 1789
14.2 Proper shipping name HYDROCHLORIC ACID
14.3 Class 8
14.4 Packing group III
14.5 Environmentally hazardous --
14.6 Special precautions for
user
no
Sea transport (IMDG)
14.1 UN number UN 1789
14.2 Proper shipping name HYDROCHLORIC ACID
14.3 Class 8
14.4 Packing group III
14.5 Environmentally hazardous --
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 113136
Product name Hydrochloric acid c(HCl) = 0.357 mol/l (1/2.8 N) Titripur®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 9 of 10
14.6 Special precautions for
user
yes
EmS F-A S-B
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
EU regulations
Occupational restrictions Take note of Dir 94/33/EC on the protection of young people at
work.
National legislation
Storage class 8B
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Full text of H-Statements referred to under sections 2 and 3.
H290 May be corrosive to metals.
H314 Causes severe skin burns and eye damage.
H335 May cause respiratory irritation.
Full text of R-phrases referred to under sections 2 and 3
R34 Causes burns.
R37 Irritating to respiratory system.
Training advice
Provide adequate information, instruction and training for operators.
Labelling
Hazard pictograms
Signal wordWarning
Hazard statementsH290 May be corrosive to metals.
Labelling (67/548/EEC or 1999/45/EC)
The product does not need to be labelled in accordance with EC directives or respective national
laws.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 113136
Product name Hydrochloric acid c(HCl) = 0.357 mol/l (1/2.8 N) Titripur®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 10 of 10
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
The information contained herein is based on the present state of our knowledge. It characterises the product with regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Revision Date 31.07.2017 Version 2.6
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 17
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE®
ACS,Reag. Ph Eur,ISO
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.
CAS-No. 1310-73-2
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Reagent for analysis, Chemical production
For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * 8th Floor, Godrej One,
Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079
India * Tel: 0091 22 6210 9000
Responsible Department Quality Assurance * Merck Life Science Private Limited *
e-mail: [email protected] *
Tel : +91-2267863131-6
1.4 Emergency telephone
number
Please contact the regional company representation in your country.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 17
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
Classification (REGULATION (EC) No 1272/2008)
Corrosive to metals, Category 1, H290
Skin corrosion, Category 1A, H314
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Hazard pictograms
Signal word
Danger
Hazard statements
H290 May be corrosive to metals.
H314 Causes severe skin burns and eye damage.
Precautionary statements
Prevention
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
Response
P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 17
Reduced labelling (≤125 ml)
Hazard pictograms
Signal word
Danger
Hazard statements
H314 Causes severe skin burns and eye damage.
Precautionary statements
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing.
P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.
CAS-No. 1310-73-2
2.3 Other hazards
None known.
SECTION 3. Composition/information on ingredients
3.1 Substance
Formula NaOH HNaO (Hill)
EC-No. 215-185-5
Molar mass 40.00 g/mol
Hazardous components (REGULATION (EC) No 1272/2008)
Chemical name (Concentration)
CAS-No. Registration number Classification
sodium hydroxide (<= 100 % )
PBT/vPvB: Not applicable for inorganic substances
1310-73-2 *)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 4 of 17
Corrosive to metals, Category 1, H290
Skin corrosion, Category 1A, H314
*) A registration number is not available for this substance as the substance or its use are exempted from registration according to Article
2 REACH Regulation (EC) No 1907/2006, the annual tonnage does not require a registration or the registration is envisaged for a later
registration deadline.
For the full text of the H-Statements mentioned in this Section, see Section 16.
3.2 Mixture
Not applicable
SECTION 4. First aid measures
4.1 Description of first aid measures
General advice
First aider needs to protect himself.
After inhalation: fresh air. Call in physician.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower. Call a physician immediately.
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove
contact lenses.
After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of
perforation). Call a physician immediately. Do not attempt to neutralise.
4.2 Most important symptoms and effects, both acute and delayed
Risk of blindness!
Irritation and corrosion, Cough, Shortness of breath, collapse, death
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 5 of 17
SECTION 5. Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Use extinguishing measures that are appropriate to local circumstances and the surrounding
environment.
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Not combustible.
Ambient fire may liberate hazardous vapours.
5.3 Advice for firefighters
Special protective equipment for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.
Further information
Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing
water from contaminating surface water or the ground water system.
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact. Ensure
adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an
expert.
Advice for emergency responders:
Protective equipment see section 8.
6.2 Environmental precautions
Do not let product enter drains.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 6 of 17
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see
sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation
of dusts.
6.4 Reference to other sections
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handling
Observe label precautions.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and
face after working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Requirements for storage areas and containers
No aluminium, tin, or zinc containers.
No metal containers.
Storage conditions
Tightly closed. Dry.
Recommended storage temperature see product label.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 7 of 17
sodium hydroxide (1310-73-2)
IN OEL Ceiling Limit Value: 2 mg/m³
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Eye/face protection
Tightly fitting safety goggles
Hand protection
full contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
splash contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 741 Dermatril® L (full contact),
KCL 741 Dermatril® L (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 8 of 17
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Other protective equipment
protective clothing
Respiratory protection
required when dusts are generated.
Recommended Filter type: Filter P 2 (acc. to DIN 3181) for solid and liquid particles of harmful
substances
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
Environmental exposure controls
Do not let product enter drains.
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
Form solid
Colour white
Odour odourless
Odour Threshold Not applicable
pH ca. > 14
at 100 g/l
20 °C
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 9 of 17
Melting point/range 319 - 322 °C
Boiling point/boiling range 1,390 °C
at 1,013 hPa
Flash point Not applicable
Evaporation rate No information available.
Flammability (solid, gas) The product is not flammable.
Lower explosion limit Not applicable
Upper explosion limit Not applicable
Vapour pressure at 20 °C
Not applicable
Relative vapour density No information available.
Density 2.13 g/cm3
at 20 °C
Relative density No information available.
Water solubility 1,090 g/l
at 20 °C
Partition coefficient: n-
octanol/water
No information available.
Auto-ignition temperature No information available.
Decomposition temperature No information available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 10 of 17
Viscosity, dynamic No information available.
Explosive properties Not classified as explosive.
Oxidizing properties none
9.2 Other data
Ignition temperature Not applicable
Corrosion May be corrosive to metals.
SECTION 10. Stability and reactivity
10.1 Reactivity
See section 10.3
10.2 Chemical stability
hygroscopic
10.3 Possibility of hazardous reactions
Violent reactions possible with:
Acetone, Chlorine, Ethylene oxide, Fluorine, Hydrogen halides, Hydrazine hydrate,
hydroxylamine, Acid anhydrides, Acrolein, Acid chlorides, Acids, sulphuric acid, Chloroform,
Water, hydrogen peroxide, anhydrides, EPICHLOROHYDRIN, phosphides, halogen-halogen
compounds, trichloroethene, ALLYL ALCOHOL
can decompose violently in contact with:
Organic Substances, hydrogen sulphide
Risk of ignition or formation of inflammable gases or vapours with:
powdered aluminium, Ammonium salts, persulfates, Sodium borohydride, phosphorus, Oxides of
phosphorus, Halogenated hydrocarbon, Light metals, Metals
Risk of explosion/exothermic reaction with:
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 11 of 17
Bromine, Calcium, in powder form, furfuryl alcohol, Nitromethane, Peroxides, organic nitro
compounds, Nitriles, Acrylic monomers, SILVER NITRATE
Chloroform, with, Acetone
Nitrobenzene, with, Methanol
Nitrobenzene, with, salts
magnesium, Zinc, and, Tin, (in the presence of atmospheric oxygen and/or moisture)
10.4 Conditions to avoid
Moisture.
10.5 Incompatible materials
Aluminium, brass, Metals, metal alloys, Zinc, Tin
10.6 Hazardous decomposition products
in the event of fire: See section 5.
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Acute oral toxicity
Symptoms: If ingested, severe burns of the mouth and throat, as well as a danger of perforation
of the oesophagus and the stomach.
Acute inhalation toxicity
Symptoms: burns of mucous membranes, Cough, Shortness of breath, Possible damages:,
damage of respiratory tract
Acute dermal toxicity
This information is not available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 12 of 17
Skin irritation
Rabbit
Result: Causes burns.
(External MSDS)
Causes severe burns.
Eye irritation
Rabbit
Result: Irreversible effects on the eye
(ECHA)
Causes serious eye damage.
Risk of blindness!
Sensitisation
Patch test: human
Result: negative
(ECHA)
Germ cell mutagenicity
Genotoxicity in vitro
Mutagenicity (mammal cell test): micronucleus.
Result: negative
(Lit.)
Ames test
Result: negative
(IUCLID)
Carcinogenicity
This information is not available.
Reproductive toxicity
This information is not available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 13 of 17
Teratogenicity
This information is not available.
Specific target organ toxicity - single exposure
This information is not available.
Specific target organ toxicity - repeated exposure
This information is not available.
Aspiration hazard
This information is not available.
11.2 Further information
Systemic effects:
collapse, death
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
SECTION 12. Ecological information
12.1 Toxicity
Toxicity to fish
LC50 Gambusia affinis (Mosquito fish): 125 mg/l; 96 h
(External MSDS)
Toxicity to daphnia and other aquatic invertebrates
EC50 Ceriodaphnia (water flea): 40.4 mg/l; 48 h
(ECHA)
Toxicity to bacteria
EC50 Photobacterium phosphoreum: 22 mg/l; 15 min
(External MSDS)
12.2 Persistence and degradability
Biodegradability
The methods for determining the biological degradability are not applicable to inorganic
substances.
12.3 Bioaccumulative potential
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 14 of 17
No information available.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
PBT/vPvB: Not applicable for inorganic substances
12.6 Other adverse effects
Additional ecological information
Harmful effect due to pH shift.
Forms corrosive mixtures with water even if diluted.
Neutralisation possible in waste water treatment plants.
Discharge into the environment must be avoided.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 15 of 17
SECTION 13. Disposal considerations
Waste treatment methods
Waste material must be disposed of in accordance with the national and local regulations. Leave
chemicals in original containers. No mixing with other waste. Handle uncleaned containers like
the product itself.
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 UN number UN 1823
14.2 Proper shipping name SODIUM HYDROXIDE, SOLID
14.3 Class 8
14.4 Packing group II
14.5 Environmentally hazardous --
14.6 Special precautions for
user
yes
Tunnel restriction code E
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)
14.1 UN number UN 1823
14.2 Proper shipping name SODIUM HYDROXIDE, SOLID
14.3 Class 8
14.4 Packing group II
14.5 Environmentally hazardous --
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 16 of 17
14.6 Special precautions for
user
no
Sea transport (IMDG)
14.1 UN number UN 1823
14.2 Proper shipping name SODIUM HYDROXIDE, SOLID
14.3 Class 8
14.4 Packing group II
14.5 Environmentally hazardous --
14.6 Special precautions for
user
yes
EmS F-A S-B
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National legislation
Storage class 8B
15.2 Chemical safety assessment
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Full text of H-Statements referred to under sections 2 and 3.
H290 May be corrosive to metals.
H314 Causes severe skin burns and eye damage.
Training advice
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106469
Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.
Ph Eur,ISO
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 17 of 17
Provide adequate information, instruction and training for operators.
Labelling
Hazard pictograms
Signal word
Danger
Hazard statements
H290 May be corrosive to metals.
H314 Causes severe skin burns and eye damage.
Precautionary statements
Prevention
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
Response
P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
Date of issue: 27.06.2014 Version: 1.0
Company: EMD Millipore Corporation | 290 Concord Road, Billerica, MA 01821, United States of America | General Inquiries: +1-978-715-4321 | Monday to Friday, 9:00 AM to 4:00 PM Eastern Time (GMT-5)
Responsible Department:
Emergency telephone number:
800-424-9300 CHEMTREC (USA) +1-703-527-3887 CHEMTREC (International) 24 Hours/day; 7 Days/week
Catalogue No.: 420311
Product name: Kanamycin Sulfate, Streptomyces kanamyceticus
REACH Registration Number:
A registration number is not available for this substance as the substance or its use are exempted from registration according to Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.
This item is not a hazardous substance and does not contain hazardous ingredients, substances with European Community workplace exposure limits or substances of very high concern (SVHC) above their respective disclosure limits. Hence a safety data sheet is not required according to Regulation (EC) No. 1907/2006 (REACH) and also not available in this case. The information has been generated by EDP and bears no signature.
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Material Safety Data SheetPhenylmethylsulfonyl fluoride MSDS
Section 1: Chemical Product and Company Identification
Product Name: Phenylmethylsulfonyl fluoride
Catalog Codes: SLP2494
CAS#: 329-98-6
RTECS: XT8040000
TSCA: TSCA 8(b) inventory: Phenylmethylsulfonyl fluoride
CI#: Not available.
Synonym: PMSF; Phenyl Methane Sulfonyl Fluoride
Chemical Name: alpha-Toluene Sulfonyl Fluoride
Chemical Formula: C7H7FO2S
Contact Information:
Sciencelab.com, Inc.14025 Smith Rd.Houston, Texas 77396
US Sales: 1-800-901-7247International Sales: 1-281-441-4400
Order Online: ScienceLab.com
CHEMTREC (24HR Emergency Telephone), call:1-800-424-9300
International CHEMTREC, call: 1-703-527-3887
For non-emergency assistance, call: 1-281-441-4400
Section 2: Composition and Information on Ingredients
Composition:
Name CAS # % by Weight
Phenylmethylsulfonyl fluoride 329-98-6 100
Toxicological Data on Ingredients: Phenylmethylsulfonyl fluoride LD50: Not available. LC50: Not available.
Section 3: Hazards Identification
Potential Acute Health Effects:Hazardous in case of ingestion. Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation.Corrosive to eyes and skin. The amount of tissue damage depends on length of contact. Eye contact can result in cornealdamage or blindness. Skin contact can produce inflammation and blistering. Inhalation of dust will produce irritation to gastro-intestinal or respiratory tract, characterized by burning, sneezing and coughing. Severe over-exposure can produce lungdamage, choking, unconsciousness or death.
Potential Chronic Health Effects:Hazardous in case of ingestion. Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation.CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available.DEVELOPMENTAL TOXICITY: Not available. Repeated exposure of the eyes to a low level of dust can produce eye irritation.Repeated skin exposure can produce local skin destruction, or dermatitis. Repeated inhalation of dust can produce varyingdegree of respiratory irritation or lung damage.
Section 4: First Aid Measures
p. 2
Eye Contact: Check for and remove any contact lenses. Do not use an eye ointment. Seek medical attention.
Skin Contact:If the chemical got onto the clothed portion of the body, remove the contaminated clothes as quickly as possible, protectingyour own hands and body. Place the victim under a deluge shower. If the chemical got on the victim's exposed skin, suchas the hands : Gently and thoroughly wash the contaminated skin with running water and non-abrasive soap. Be particularlycareful to clean folds, crevices, creases and groin. If irritation persists, seek medical attention. Wash contaminated clothingbefore reusing.
Serious Skin Contact:Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention.
Inhalation: Allow the victim to rest in a well ventilated area. Seek immediate medical attention.
Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Ifbreathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It maybe hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious orcorrosive. Seek immediate medical attention.
Ingestion:Do not induce vomiting. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, performmouth-to-mouth resuscitation. Seek immediate medical attention.
Serious Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: May be combustible at high temperature.
Auto-Ignition Temperature: Not available.
Flash Points: Not available.
Flammable Limits: Not available.
Products of Combustion: These products are carbon oxides (CO, CO2), halogenated compounds.
Fire Hazards in Presence of Various Substances: Not available.
Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product inpresence of static discharge: Not available.
Fire Fighting Media and Instructions:SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on Fire Hazards: Not available.
Special Remarks on Explosion Hazards: Not available.
Section 6: Accidental Release Measures
Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container.
Large Spill:Corrosive solid. Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Use water spray toreduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all ignition sources. Call forassistance on disposal.
Section 7: Handling and Storage
p. 3
Precautions:Keep container dry. Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporatethe residue under a fume hood. Ground all equipment containing material. Do not breathe dust. Never add water to thisproduct Wear suitable protective clothing If ingested, seek medical advice immediately and show the container or the label.May corrode glass. Store in an appropriate container.
Storage:May corrode glass. Store in an appropriate container. Keep container dry. Keep in a cool place. Ground all equipmentcontaining material. Corrosive materials should be stored in a separate safety storage cabinet or room.
Section 8: Exposure Controls/Personal Protection
Engineering Controls:Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommendedexposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminantsbelow the exposure limit.
Personal Protection:Splash goggles. Synthetic apron. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.
Exposure Limits: Not available.
Section 9: Physical and Chemical Properties
Physical state and appearance: Solid.
Odor: Not available.
Taste: Not available.
Molecular Weight: 174.19 g/mole
Color: Not available.
pH (1% soln/water): Not available.
Boiling Point: Decomposes.
Melting Point: 92°C (197.6°F)
Critical Temperature: Not available.
Specific Gravity: Not available.
Vapor Pressure: Not applicable.
Vapor Density: Not available.
Volatility: Not available.
Odor Threshold: Not available.
Water/Oil Dist. Coeff.: Not available.
Ionicity (in Water): Not available.
Dispersion Properties: Not available.
Solubility: Not available.
p. 4
Section 10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Not available.
Incompatibility with various substances: Not available.
Corrosivity: Corrosive in presence of glass.
Special Remarks on Reactivity: Not available.
Special Remarks on Corrosivity: Not available.
Polymerization: No.
Section 11: Toxicological Information
Routes of Entry: Ingestion.
Toxicity to Animals:LD50: Not available. LC50: Not available.
Chronic Effects on Humans: Not available.
Other Toxic Effects on Humans:Hazardous in case of ingestion. Slightly hazardous in case of skin contact (irritant), of inhalation.
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans: Not available.
Special Remarks on other Toxic Effects on Humans: Not available.
Section 12: Ecological Information
Ecotoxicity: Not available.
BOD5 and COD: Not available.
Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The products of degradation are more toxic.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste Disposal:
Section 14: Transport Information
DOT Classification: CLASS 8: Corrosive solid.
Identification: : Corrosive solid, n.o.s. (Toluene sulfonyl fluoride) : UN1759 PG: III
Special Provisions for Transport: Not available.
p. 5
Section 15: Other Regulatory Information
Federal and State Regulations: TSCA 8(b) inventory: Phenylmethylsulfonyl fluoride
Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
Other Classifications:
WHMIS (Canada): CLASS E: Corrosive solid.
DSCL (EEC):This product is not classified according to the EU regulations.
HMIS (U.S.A.):
Health Hazard: 3
Fire Hazard: 1
Reactivity: 0
Personal Protection:
National Fire Protection Association (U.S.A.):
Health: 3
Flammability: 1
Reactivity: 0
Specific hazard:
Protective Equipment:Gloves. Synthetic apron. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriaterespirator when ventilation is inadequate. Splash goggles.
Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.
Created: 10/10/2005 11:22 AM
Last Updated: 05/21/2013 12:00 PM
The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.
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E
Material Safety Data SheetImidazole MSDS
Section 1: Chemical Product and Company Identification
Product Name: Imidazole
Catalog Codes: SLI1588
CAS#: 288-32-4
RTECS: NI3325000
TSCA: TSCA 8(b) inventory: Imidazole
CI#: Not available.
Synonym:
Chemical Formula: C3H4N2
Contact Information:
Sciencelab.com, Inc.14025 Smith Rd.Houston, Texas 77396
US Sales: 1-800-901-7247International Sales: 1-281-441-4400
Order Online: ScienceLab.com
CHEMTREC (24HR Emergency Telephone), call:1-800-424-9300
International CHEMTREC, call: 1-703-527-3887
For non-emergency assistance, call: 1-281-441-4400
Section 2: Composition and Information on Ingredients
Composition:
Name CAS # % by Weight
Imidazole 288-32-4 100
Toxicological Data on Ingredients: Imidazole: ORAL (LD50): Acute: 220 mg/kg [Rat]. 880 mg/kg [Mouse].
Section 3: Hazards Identification
Potential Acute Health Effects:Very hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Inflammation of the eyeis characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,occasionally, blistering.
Potential Chronic Health Effects:Very hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. CARCINOGENICEFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available.DEVELOPMENTAL TOXICITY: Not available. Repeated or prolonged inhalation of dust may lead to chronic respiratoryirritation.
Section 4: First Aid Measures
Eye Contact:
p. 2
Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelidsopen. Cold water may be used. Do not use an eye ointment. Seek medical attention.
Skin Contact:After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin with runningwater and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin. Cold water may be used.Cover the irritated skin with an emollient. If irritation persists, seek medical attention. Wash contaminated clothing beforereusing.
Serious Skin Contact:Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medicalattention.
Inhalation: Allow the victim to rest in a well ventilated area. Seek immediate medical attention.
Serious Inhalation: Not available.
Ingestion:Do not induce vomiting. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication thatthe toxic material was ingested; the absence of such signs, however, is not conclusive. Loosen tight clothing such as a collar,tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention.
Serious Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: May be combustible at high temperature.
Auto-Ignition Temperature: Not available.
Flash Points: CLOSED CUP: 145°C (293°F).
Flammable Limits: Not available.
Products of Combustion: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).
Fire Hazards in Presence of Various Substances: Not available.
Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product inpresence of static discharge: Not available.
Fire Fighting Media and Instructions:SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on Fire Hazards: Not available.
Special Remarks on Explosion Hazards: Not available.
Section 6: Accidental Release Measures
Small Spill:Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water onthe contaminated surface and dispose of according to local and regional authority requirements.
Large Spill:Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on thecontaminated surface and allow to evacuate through the sanitary system.
Section 7: Handling and Storage
Precautions:
p. 3
Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under afume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. In case of insufficient ventilation,wear suitable respiratory equipment If ingested, seek medical advice immediately and show the container or the label. Avoidcontact with skin and eyes
Storage:Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly closed. Keep in acool, well-ventilated place. Combustible materials should be stored away from extreme heat and away from strong oxidizingagents.
Section 8: Exposure Controls/Personal Protection
Engineering Controls:Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommendedexposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminantsbelow the exposure limit.
Personal Protection:Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.
Exposure Limits: Not available.
Section 9: Physical and Chemical Properties
Physical state and appearance: Solid.
Odor: Not available.
Taste: Not available.
Molecular Weight: 68.08 g/mole
Color: Not available.
pH (1% soln/water): Not available.
Boiling Point: 256°C (492.8°F)
Melting Point: 90°C (194°F)
Critical Temperature: Not available.
Specific Gravity: Not available.
Vapor Pressure: Not applicable.
Vapor Density: Not available.
Volatility: Not available.
Odor Threshold: Not available.
Water/Oil Dist. Coeff.: Not available.
Ionicity (in Water): Not available.
Dispersion Properties: See solubility in water.
Solubility: Easily soluble in cold water.
p. 4
Section 10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Not available.
Incompatibility with various substances: Not available.
Corrosivity: Non-corrosive in presence of glass.
Special Remarks on Reactivity: Not available.
Special Remarks on Corrosivity: Not available.
Polymerization: No.
Section 11: Toxicological Information
Routes of Entry: Eye contact. Inhalation. Ingestion.
Toxicity to Animals: Acute oral toxicity (LD50): 220 mg/kg [Rat].
Chronic Effects on Humans: Not available.
Other Toxic Effects on Humans: Very hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans: Not available.
Special Remarks on other Toxic Effects on Humans: Not available.
Section 12: Ecological Information
Ecotoxicity: Not available.
BOD5 and COD: Not available.
Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The products of degradation are more toxic.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste Disposal:
Section 14: Transport Information
DOT Classification: Not a DOT controlled material (United States).
Identification: Not applicable.
Special Provisions for Transport: Not applicable.
Section 15: Other Regulatory Information
p. 5
Federal and State Regulations: TSCA 8(b) inventory: Imidazole
Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
Other Classifications:
WHMIS (Canada):CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC). CLASS D-2B: Material causing other toxic effects(TOXIC).
DSCL (EEC):R22- Harmful if swallowed. R38- Irritating to skin. R41- Risk of serious damage to eyes.
HMIS (U.S.A.):
Health Hazard: 2
Fire Hazard: 1
Reactivity: 0
Personal Protection: E
National Fire Protection Association (U.S.A.):
Health: 2
Flammability: 1
Reactivity: 0
Specific hazard:
Protective Equipment:Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Splash goggles.
Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.
Created: 10/10/2005 08:20 PM
Last Updated: 05/21/2013 12:00 PM
The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Revision Date 03.01.2017 Version 1.1
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 11
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 106268
Product name Sodium acetate anhydrous for analysis EMSURE® ACS,Reag. Ph Eur
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.
CAS-No. 127-09-3
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Reagent for analysis
For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * 8th Floor, Godrej One,
Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079
India * Tel: 0091 22 6210 9000
Responsible Department Quality Assurance * Merck Life Science Private Limited *
e-mail: [email protected] *
Tel : +91-2267863131-6
1.4 Emergency telephone
number
Please contact the regional company representation in your country.
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
This substance is not classified as dangerous according to European Union legislation.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106268
Product name Sodium acetate anhydrous for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 11
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
2.3 Other hazards
None known.
SECTION 3. Composition/information on ingredients
3.1 Substance
Formula CH₃COONa C₂H₃NaO₂ (Hill)
EC-No. 204-823-8
Molar mass 82.03 g/mol
Remarks No disclosure requirement according to Regulation (EC) No.
1907/2006
3.2 Mixture
Not applicable
SECTION 4. First aid measures
4.1 Description of first aid measures
After inhalation: fresh air.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower.
After eye contact: rinse out with plenty of water.
After swallowing: make victim drink water (two glasses at most). Consult doctor if feeling unwell.
4.2 Most important symptoms and effects, both acute and delayed
irritant effects, Stomach/intestinal disorders
4.3 Indication of any immediate medical attention and special treatment needed
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106268
Product name Sodium acetate anhydrous for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 11
No information available.
SECTION 5. Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Water, Foam, Carbon dioxide (CO2), Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Combustible.
Vapours are heavier than air and may spread along floors.
Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
5.3 Advice for firefighters
Special protective equipment for firefighters
In the event of fire, wear self-contained breathing apparatus.
Further information
Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing
water from contaminating surface water or the ground water system.
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid inhalation of dusts. Evacuate the danger area,
observe emergency procedures, consult an expert.
Advice for emergency responders:
Protective equipment see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106268
Product name Sodium acetate anhydrous for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 4 of 11
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see
sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation
of dusts.
6.4 Reference to other sections
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handling
Observe label precautions.
Hygiene measures
Change contaminated clothing. Wash hands after working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed. Dry.
Recommended storage temperature see product label.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
Contains no substances with occupational exposure limit values.
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106268
Product name Sodium acetate anhydrous for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 5 of 11
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Eye/face protection
Safety glasses
Hand protection
full contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
splash contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 741 Dermatril® L (full contact),
KCL 741 Dermatril® L (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Respiratory protection
required when dusts are generated.
Recommended Filter type: Filter P 1 (acc. to DIN 3181) for solid particles of inert substances
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
Environmental exposure controls
Do not let product enter drains.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106268
Product name Sodium acetate anhydrous for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 6 of 11
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
Form powder
Colour colourless
Odour odourless
Odour Threshold Not applicable
pH 7.5 - 9.2
at 30 g/l
20 °C
Melting point 324 °C
(decomposition)
Boiling point/boiling range > 400 °C
(decomposition)
Flash point > 250 °C
Method: c.c.
Evaporation rate No information available.
Flammability (solid, gas) No information available.
Lower explosion limit No information available.
Upper explosion limit No information available.
Vapour pressure at 20 °C
Not applicable
Relative vapour density No information available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106268
Product name Sodium acetate anhydrous for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 7 of 11
Density 1.52 g/cm3
at 20 °C
Relative density No information available.
Water solubility 365 g/l
at 20 °C
Partition coefficient: n-
octanol/water
log Pow: -4.22
Bioaccumulation is not expected.
Auto-ignition temperature No information available.
Decomposition temperature No information available.
Viscosity, dynamic No information available.
Explosive properties Not classified as explosive.
Oxidizing properties none
9.2 Other data
Ignition temperature 607 °C
SECTION 10. Stability and reactivity
10.1 Reactivity
Forms explosive mixtures with air on intense heating.
A range from approx. 15 Kelvin below the flash point is to be rated as critical.
The following applies in general to flammable organic substances and mixtures: in
correspondingly fine distribution, when whirled up a dust explosion potential may generally be
assumed.
10.2 Chemical stability
hygroscopic
10.3 Possibility of hazardous reactions
Risk of explosion with:
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106268
Product name Sodium acetate anhydrous for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 8 of 11
nitrates
Exothermic reaction with:
Fluorine
10.4 Conditions to avoid
Strong heating.
10.5 Incompatible materials
no information available
10.6 Hazardous decomposition products
in the event of fire: See section 5.
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Acute oral toxicity
LD50 Rat: 3,530 mg/kg
(RTECS)
Symptoms: Stomach/intestinal disorders
Acute inhalation toxicity
LC50 Rat: > 30 mg/l; 1 h ; dust/mist
(RTECS)
Symptoms: mucosal irritations
Acute dermal toxicity
LD50 Rabbit: > 10,000 mg/kg
(RTECS)
Skin irritation
slight irritation
Eye irritation
slight irritation
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106268
Product name Sodium acetate anhydrous for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 9 of 11
Sensitisation
This information is not available.
Germ cell mutagenicity
Genotoxicity in vitro
Ames test
Result: negative
(IUCLID)
Carcinogenicity
This information is not available.
Reproductive toxicity
This information is not available.
Teratogenicity
Did not show teratogenic effects in animal experiments. (IUCLID)
Specific target organ toxicity - single exposure
This information is not available.
Specific target organ toxicity - repeated exposure
This information is not available.
Aspiration hazard
This information is not available.
11.2 Further information
Hazardous properties cannot be excluded but are unlikely when the product is handled
appropriately.
Handle in accordance with good industrial hygiene and safety practice.
SECTION 12. Ecological information
12.1 Toxicity
Toxicity to fish
LC50 Lepomis macrochirus (Bluegill sunfish): 5,000 mg/l; 24 h
(Lit.)
Toxicity to daphnia and other aquatic invertebrates
EC50 Daphnia magna (Water flea): > 1,000 mg/l; 48 h
(IUCLID)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106268
Product name Sodium acetate anhydrous for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 10 of 11
Toxicity to bacteria
EC50 Pseudomonas putida: 7,200 mg/l; 18 h
(IUCLID)
12.2 Persistence and degradability
Biodegradability
99 %; 28 d
OECD Test Guideline 301A
Readily biodegradable
12.3 Bioaccumulative potential
Partition coefficient: n-octanol/water
log Pow: -4.22
Bioaccumulation is not expected.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.
12.6 Other adverse effects
Discharge into the environment must be avoided.
SECTION 13. Disposal considerations
Waste treatment methods
Waste material must be disposed of in accordance with the national and local regulations. Leave
chemicals in original containers. No mixing with other waste. Handle uncleaned containers like
the product itself.
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Inland waterway transport (ADN)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106268
Product name Sodium acetate anhydrous for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 11 of 11
Not relevant
Air transport (IATA)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Sea transport (IMDG)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National legislation
Storage class 10 - 13
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Training advice
Provide adequate information, instruction and training for operators.
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
Palabora Copper (Pty) Limited
MSDS – Nickel Sulphate Date printed: 21 November 2014 Rev: 2.2 (Last revision date: 26 August 2013) Effective:13 March 2008 Any printed document is an uncontrolled document Page 1 of 13
SUPPLIER DETAILS
Supplier Name:
Address:
Person Responsible
for Updating MSDS:
Palabora Copper (Pty)
Limited
PO Box 65
1 Copper Road
Phalaborwa
1390
South Africa
Manager:
Environment & SHEQ
MS
Emergency Telephone
Number:
E-Mail Address:
Telephone Number:
Fax Number:
URL / WebPages:
+27 (0)15 780 2666
+27 (0)15 780 2281
+27 (0)15 780 2100
http://www.palabora.com/
1. PRODUCT IDENTIFICATION
Chemical Names and Synonyms: Nickel (II) Sulphate Hexahydrate, NiSO4.6H2O
UN Number: 3077
CAS Number: 10101-97-0 NIOSH Number: /
2. COMPOSITION
Nickel (II) Sulphate hexahydrate - 95% CAS Number: 10101-97-0 Molar Mass: 262.86 Molecular Formula: NiSO4.6H2O EC-Index Number: 028-009-00-5 EC-Number: 232-104-9
3. HAZARDOUS IDENTIFICATION
HAZARD CLASSIFICATION & LABELING: Human Health and Environment
ENDPOINT
GHS
CLASSIFICATION M-Factor
Hazard Class & Category
Code
Hazard Statement Code
Dermal Irritation/Skin Corrosion (GHS)
Skin Irrit. 2 H315 M = 1
Dermal Sensitization Skin Sens. 1 H317
Mutagenicity Muta. 2 H341
Acute Oral Toxicity Acute Tox. 4 H302
Acute Inhalation Toxicity Acute Tox. 4 H332
Chronic Toxicity/STOT-RE (inhalation)
STOT RE 1 H372
Reproductive Toxicity Repr. 1B H360D
Carcinogenicity (inhalation) Carc. 1A H350i
Respiratory Sensitization Resp. Sens. 1 H334
Acute Aquatic Environment Aquatic Acute 1 H400
Chronic Aquatic Environment Aquatic Chronic 1 H410
Material Safety Data Sheet Nickel Sulphate
Palabora Copper (Pty) Limited
MSDS – Nickel Sulphate Date printed: 21 November 2014 Rev: 2.2 (Last revision date: 26 August 2013) Effective:13 March 2008 Any printed document is an uncontrolled document Page 2 of 13
4. FIRST AID MEASURES
Inhalation - Fresh air. Seek medical attention
Skin Contact - Remove contaminated clothing including shoes. Wash affected area with plenty of soap and water for at least 20 minutes.
Eye Contact - Rinse out with plenty of water with the eyelid held wide open. Seek medical attention.
Ingestion - Large quantities of water should be drunk. Seek medical attention.
Wounds - Cleanse thoroughly to remove any nickel sulphate particles.
5. FIRE FIGHTING MEASURES
Special Risks - Non-combustible. Development of hazardous combustion gases or vapours possible in the event of fire. The following may be present in the event of fire. Sulphur Oxides Special Protective Equipment for Fire Fighting - Do not stay in dangerous zone without suitable chemical protection clothing and self-contained breathing apparatus. Other Information - Contain escaping vapours with water. Prevent fire-fighting water from entering surface water or groundwater Suitable Extinguishing Media - Adapt to materials stored in the immediate vicinity.
6. ACCIDENTAL RELEASE MEASURES
Person-related precautionary measures: Avoid substance contact. Avoid generation of dusts. Do not inhale dusts.
Environment protection measures: Do not allow to enter aquatic system.
Procedures for cleaning/absorption: Pick up dry - Collect spills by sweeping or vacuuming with the vacuum exhaust passing through a high efficiency particulate arresting filter if exhaust is discharged into the work place. Avoid generation of dusts. Dispose of spills in accordance with local regulations. Clean up affected area.
7. HANDLING AND STORAGE
Keep in the container supplied and keep container closed when not in use. Wear appropriate protective clothing, including waterproof gloves and nationally approved respirators. Follow local regulations regarding the storage of this material.
Palabora Copper (Pty) Limited
MSDS – Nickel Sulphate Date printed: 21 November 2014 Rev: 2.2 (Last revision date: 26 August 2013) Effective:13 March 2008 Any printed document is an uncontrolled document Page 3 of 13
8. EXPOSURE CONTROLS / PERSONAL PROTECTION
The following source of information on Occupational Exposure Limits from Member States is the OSHA (European Agency for Safety and Health at work) website: http://osha.europa.eu/en/topics/ds/oel/index.stm/members.stm The following current national limit values for Nickel and its compounds (November 2010)
Area
Country
Current OELs (mg Ni / m3)
Soluble Metallic Nickel
oxide and
carbonate
Insoluble Nickel Carbonyl (liquid)
as Ni(CO)4
Europe Finland 0.1 1 0.1 0.1 0.007 (0.021 STEL) (both as Ni(CO)4)
Norway 0.05 0.05 - 0.05 0.007 (as Ni(CO)4)
UK 0.1 (MEL#) 0.5 (MEL
#) - 0.5 0.24 (STEL, as Ni)
France 0.1 1 (VME)*
1 1 0.12 (as Ni)
Germany No legally binding OEL currently in place
Belgium 0.1 1 - 0.2** 0.12 (as Ni)
Denmark 0.01 0.05 - 0.05 0.007 (as Ni(CO)4)
Italy 0. 1 1 - 1 0.12 (as Ni)
Non-
Europe
USA (OSHA) 1 1 - 1 0.007 (as Ni(CO)4)
USA - ACGIH (TLV) Non- enforceable standard
0.1#
1.5# - 0.2**
# 0.12 (as Ni) and 0.35 as Ni(CO)4
Canada - most jurisdictions
0.1 1.5 - 0.2**# 0.35 (as Ni(CO)4)
Canada - Ontario 0.1 1 - 0.2**#
0.35 (as Ni(CO)4)
Canada - BC 0.05 0.05 - 0.05 0.007 (as Ni(CO)4)
Canada - Qc, NT, NU, YT
0.1 1 - 1 0.35 (as Ni(CO)4)
Japan 0.1 - 0.1 0.1 0.007 (as Ni(CO)4)
Australia 0.1 1 - 1$ 0.12 (as Ni)
South Africa 0.1 0.5 - 0.5** 0.24 (STEL, as Ni)
*VME = Valeur Moyenne d'Exposition. The value of 1 mg/rn
3 applies to nickel carbonate, dihydroxide, subsulfide,
monoxide, sulphide trioxide and for other chemical forms not otherwise specified, such as "insoluble nickel compounds" and nickel sulfide roasting fume and dust. ** For nickel subsulfide the value is 0.1 mg Ni/m
3 as inhalable.
# Inhalable
$ Nickel sulphides roasting fumes only
MEL Maximum Exposure Limit STEL Short term exposure level OEL Occupational exposure limit
Palabora Copper (Pty) Limited
MSDS – Nickel Sulphate Date printed: 21 November 2014 Rev: 2.2 (Last revision date: 26 August 2013) Effective:13 March 2008 Any printed document is an uncontrolled document Page 4 of 13
TWA Time-weighted average exposure TLV Threshold Limit Value
Personal Protective Equipment: Respiratory protection - Required when dust is generated Eye Protection - Required Hand Protection - Required
Industrial Hygiene: Protective clothing should be selected specifically for the working place, depending on the concentration and quantity of the hazardous substances handled. Avoid repeated skin and eye contact. Wear goggles or face shield. Wear suitable protective clothing and waterproof gloves. Wash skin thoroughly after handling and before eating, drinking or smoking. Launder clothing and gloves as needed. Application of skin-protective barrier cream is recommended.
9. PHYSICAL AND CHEMICAL PROPERTIES
Form: Crystals Colour: Green Odour: Odourless Formula: NiSO4.6H2O pH value @ 100g/l H2O, 20 deg C 4.3 - 4.7 Melting temperature 53 deg C (loss of water of crystallisation on heating) Boiling temperature not applicable Ignition temperature not applicable Flash point not applicable Explosion limit Non-explosive Relative vapour density not applicable Relative density @ 20 deg C 2.07 g/cm
3
Bulk Density ± 1000 kg/m3 Solubility in water @ 20 deg C 625 g/l water @ 100 deg C 3407 g/l Thermal decomposition > 700 deg C
10. STABILITY AND REACTIVITY
Conditions to be avoided: Strong Heating Substances to be avoided: Strong Acids Hazardous decomposition products: In the event of fire - toxic vapours (Sulphur Oxides) Further Information: Releasing water of crystallization - when heated.
Palabora Copper (Pty) Limited
MSDS – Nickel Sulphate Date printed: 21 November 2014 Rev: 2.2 (Last revision date: 26 August 2013) Effective:13 March 2008 Any printed document is an uncontrolled document Page 5 of 13
11. TOXICOLOGICAL INFORMATION
Toxicity endpoints Description of effects
Absorption ORAL = 30% from food during fasting; 5% from absorption of nickel from food, soil, dust and from water consumed with food [In vivo rat, human study and modeling of human data] (Ishimatsu et al., 1995; Sunderman et al., 1989; Nielsen et al., 1999; Diamond et al.,1998; EURA, 2008-2009) DERMAL = 2% [In vivo human skin stripping and in vitro human stratum corneum] (Hostynek et al., 2001; Tanojo et al., 2001; EURA, 2008-2009) INHALATION = 100% (aerodynamic diameter below 5 µm = respirable fraction), negligible (aerodynamic diameters >5 µm = non-respirable fraction) [Animal studies and read across from nickel chloride rat in vivo intratracheal instillation studies] (Medinsky et al., 1987; Benson et al., 1995; Carvalho and Ziemer, 1982; English et al., 1981; Clary, 1975; EURA, 2008-2009)
Acute toxicity ORAL: LD50= 361.9 mg NiSO4·6H2O/kg bw. Classified as Category 4. [OECD Guideline 425] (EPSL, 2009a; FDRL, 1983) DERMAL: No studies have been found on acute toxicity by the dermal route but dermal absorption is low so toxicity is not expected. INHALATION: LC50= 2.48 mg NiSO4·6H2O/L. Classified as Category 4 [OECD Guideline 403 study] (EPSL, 2009b)
Skin
corrosion/irritation
Nickel sulphate is classified as Category 2 for skin irritaton with a 20% concentration limit. [Human patch testing] (Frosch and Kligman, 1976; Seidenari et al., 1996)
Serious eye
damage/irritation
Nickel sulphate is not an eye irritant. [OECD Guideline 405 study] (SLI, 1999)
Respiratory or skin
sensitisation
DERMAL: Nickel sulphate is a dermal sensitizer classified as Category 1. [Guinea Pig Maximization Test sudies] (Rohold et al., 1991; FDRL, 1986; Lammintausta et al., 1985; Nielsen et al., 1992) RESPIRATORY: Nickel sulphate is a respiratory sensitizer classified as Category 1. [Weight of evidence from human case reports] (Block and Yeung, 1982; Malo et al., 1982; Malo et al., 1985; McConnell et al., 1973; Novey et al., 1983)
Germ cell
Mutagenicity
Nickel sulphate is mutagenic and is classified Category 2. [In vivo mutagenicity testing and in vivo testing weight of evidence] (Larramendy et al., 1981; Oller and Erexson, 2007)
Carcinogenicity ORAL: Nickel sulphate is not carcinogenic by the oral route of exposure. [OECD Guideline 451 and EPA OPPTS 870.4200 study] (Heim et al., 2007) DERMAL: Not relevant since negligible amount of absorption by dermal exposure. INHALATION: Nickel sulphate in currently classified as Category 1A for inhalation exposure. [Human epidemiological studies and 2-year rat inhalation OECD Guideline 453] (Doll et al., 1990; Grimsrud et al., 2002; Antilla et al., 1998; Roberts et al., 1989; Andersen et al., 1996; Pang et al., 1996; NTP, 1996)
Reproductive toxicity Nickel sulphate is a Category 1B reproductive toxicant. [OECD Guideline 416- 2 generation study] (SLI, 2000)
STOT-single
exposure
Available data do not indicate potential for single target organ toxicity. (References are included in other endpoint summaries.)
STOT-repeated dose
toxicity
ORAL: Lack of toxicity demonstrated in available studies. (References are included in other endpoint summaries.) DERMAL: Lack of toxicity from dermal exposure since dermal absorption is negligible. INHALATION: Classified as Category 1 for inhalation exposure due to lung effects. NOAEC = 0.027 mg Ni/m³ [Data from 2-year rat inhalation OECD Guideline 453 study] (NTP, 1996)
Aspiration hazard Not applicable.
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12. ECOLOGICAL INFORMATION
Endpoints Description of effects
Toxicity Ecotoxicity Reference Values (ERVs) for nickel substances:
Acute = 120 µg Ni/L (pH 6), 68 µg Ni/L (pH 8)
Chronic = 2.4 µg Ni/L
Short-term toxicity to aquatic invertebrates:
Invertebrates 48h LC50 (immobilization) (freshwater): Range from 0.013 mg Ni/L [Ceriodaphnia dubia] (Schubauer-Berigan et al., 1993) to 4970 mg Ni/L [Daphnia magna] (Chapman et al., 1980) (immobilization).
Invertebrates 48h LC50 mortality (marine): Range from 0.23 mg/L [Haliotis refescens] (Hunt et al., 2002) to 415 mg/L (Penaeus duorarum] (Bentley et al., 1975).
Short-term toxicity to fish:
Fish 96 hour (freshwater): Range from 0.23 mg Ni/L [Pimephales promelas] (Hoang et al., 2004) to 320 mg Ni/L [Brachydanio rerio] (Janssen Pharmaceutica, 1993) (mortality).
Fish 96h LC50 mortality values (marine): Range from 26.6 mg Ni/L [Atherinops affinis] (Hunt et al., 2002) to 350 mg Ni/L [Fundulus heteroclitus] (Eisler and Hennekey, 1977).
Long-term toxicity to aquatic invertebrates:
Invertebrates population growth rate (15 species) (freshwater): Range of 1.4 μg/L [Lymnaea stagnalis] (growth) to 1379 µg/L [Brachionus calyciflorus] (Stubblefield and Van Genderen, 2007).
Invertebrates (9 species) (marine): Range from 22.5 µg Ni/L [Neanthes arenaceodentata reproduction] (Parametrix 2007b) to 335 µg Ni/L [Strongylocentrotus purpuratus development] (Parametrix 2007c).
Long-term toxicity to fish:
Fish (3 species) (freshwater): Range of 40 µg Ni/L [Brachydanio rerio for hatchability] to 1548 µg Ni/L [Oncorhynchus mykiss for growth] (Deleebeeck et al., 2007).
Fish EC10 (2 species) (marine): Range from 3599 µg Ni/L [Atherinops affinis growth] (Hunt et al., 2002) to 20760 µg Ni/L [Cyprinodon variegatus growth] (Golder Associates, 2007).
Toxicity to aquatic algae and cyanobacteria:
Algae growth rate (9 values) (freshwater): Range of 12.3 µg Ni/L [Scenedesmus accumulates] (Deleebeeck et al., 2006) to 51.8 µg Ni/L [Coelastrum microporum] (Deleebeeck et al., 2006) (growth rate)
Algae growth (4 species) (marine): Range from 97 µg Ni/L [Macrocystis pyrifera] (Golder, 2007) to 17891 µg Ni/L [Dunaliella tertiolectaI] (Parametrix 2007a).
Toxicity to aquatic plants other than algae:
Higher aquatic plants growth inhibition (freshwater): Range of 8.2 µg Ni/L [Lemna gibba] (Klain & Knuteson, 2003) and 80 µg Ni/L [Lemna minor] (Antunes, 2007)
Toxicity to microorganisms:
Inhibition of Oxygen Consumption EC50: 33 mg/L [Test for by Activated Sludge- ISO 8192] (Cokgor et al.,2007)
Toxicity to other aquatic organisms:
Amphibians (3 species) (freshwater): Range of 84.5 µg Ni/L to 13,147 µg Ni/L [Xenopus laevis malformation] (Hopfer et al., 1991).
Sediment toxicity:
Pending outcome of sediment testing program (conclusion i of EU Existing Substances Risk Assessment).
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Toxicity to soil macro-organisms:
Macroinvertebrates (acute): Range from 52 mg Ni/kg dw [Lumbicis terrestris mortality] (Furst et al., 1993) to 2,500 mg Ni/kg dw [Caenorhabditis elegans mortality] (Boyd and Williams, 2003).
Invertebrates (6 species) (chronic): Range from 36 mg Ni/kg [Folsomia candidate reproduction] to 1140 mg Ni/kg [Eisenia fetida reproduction] (Ghent University, 2005).
Toxicity to terrestrial plants:
Plants EC50 (4 d) values (acute): Range from ≥54.5 mg/kg soil d.w. to ≤1928.2 mg/kg [Hordeum vulgare root elongation] (Thakali et al., 2006).
Plants (11 species) (chronic): Range from 10 mg Ni/kg [Spinacea oleracea total yield] (Willaert & Verloo, 1988) to 1127 mg Ni/kg [Hordeum vulgare root yield] (Rothamsted Research, 2005).
Toxicity to soil micro-organisms:
Microbial processes (12 processes) (chronic): Range from 28 mg Ni/kg [nitrification] (Smolders, 2000) to 2542 mg Ni/kg [respiration] (Doelman & Haanstra, 1984).
Enzyme activity in soil (chronic): Range from 7.9 mg Ni/kg [dehydrogenase] (Welp, 1999) to 7084 mg Ni/kg [arylsulfatase activity] (Haanstra and Deolman, 1991).
Microbial species growth (13 species) (chronic): Range from 13 mg Ni/kg [Aspergillus clavatus] to 530 mg Ni/kg for [Trichoderma viride] (Babich & Stotzky, 1982).
Persistence and
degradability
Not applicable to inorganic substances. Information about the extent of nickel partitioning from the water column and transformation to less toxic or non-toxic nickel species is currently being evaluated in the context of the CLP criteria. This evaluation will be completed and available by 1 December 2012.
Bioaccumulative
potential
Aquatic bioaccumulation
Freshwater aqueous: Range from 0.8 [Oncorhynchus mykiss, muscle w.w., 180 d flow-through] (Calamari et al., 1982) to 5613 [Anacystis nidulans, whole body d.w., 48h static] (Azeez and Banerjee, 1991)
Freshwater sediment: 6150 [Cerastoderma edule, whole body w.w., field study] (Bryan and Hummerstone, 1977)
Saltwater aqueous: Range from 3 (C. margaritacea, whole body w.w., field study] (Walting, 1983) to 26500 (Cerastoderma edule whole body d.w., 26 d semi-static] (Waegeneers and Smolders, 2003)
McGeer et al. (2003) aggregated whole fish tissue data published by Lind et al. (1978) and Blaylock and Frank (1979). A BCF of 270 was calculated from this linear relationship. Where C. edule was a relevant prey item for marine food chains, the value of 1631 (Boyden, 1975) was relevant.
Terrestrial bioaccumulation (BSAF)
Range from 0.013 [lettuce, edible fraction] (DiSalvatore et al., 2009) to 1.86 [Allolobophora caligonosa, whole body d.w. (Plaggen soil)] (Ma, 1982)
All BAFs were pooled and log normally distributed, resulting in a BAF geometric mean from the cumulative frequency distribution of 0.30 (EURA, 2008-2009)
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Mobility in soil Kp- Soil: log Kp soil 2.86 [Aqua regia digestion- ISO 11466, 46 European soils](De Groot et al., 1998).
Results of PBT and
vPvB assessment
The PBT and vPvB criteria of Annex XIII to the Regulation does not apply to inorganic substances, such as nickel and inorganic nickel compounds.
Other adverse effects Not applicable.
13. DISPOSAL CONSIDERATIONS
Product: A distinction must be made between "wastes for recycling" and "wastes for disposal". Please contact the competent body (authority or waste disposal company) where you will obtain information on recycling or disposal.
Packaging: Disposal to be in compliance with official regulations. Handle contaminated packaging in the same way as the substance itself. If not officially specified differently, non-contaminated packaging may be treated like household or recycled.
14. TRANSPORT INFORMATION
Land transport - Transport according to SABS code of practice (0230, 0231,0232) Sea Transport - Ship in a closed container. UN Proper Shipping Name - ENVIRONMENTALLY HAZARDOUS SUBSTANCE SOLID N.O.S. (Nickel Sulphate) Transport Hazard Class: 9 Packaging Group: III The transport regulations are cited according to International Regulations, and may depend on Country-to-Country and volume to be transported.
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15. REGULATORY INFORMATION
Labeling: Hazard pictograms:
Signal word: danger Hazard statements:
LABELLING HAZARDOUS STATEMENT CODE DESCRIPTION
Hazard Statement
Code
H302
H315
H317
H332
H334
H341
H350i
H360D
H372
H410
H302 = Harmful if swallowed
H315 = Causes skin irritation
H317 = May cause an allergic skin reaction
H332 =Harmful if inhaled
H334 = May cause allergy or asthma symptoms or breathing difficulties if inhaled
H341 = Suspected of causing genetic defects
H350i = May cause cancer via inhalation
H360D = May damage the unborn child
H372 =Causes damage to lungs through prolonged or repeated exposure via inhalation
H400 = Very toxic to aquatic life
H410 =Very toxic to aquatic life with long lasting effects
EC No - 232-104-9
16. OTHER INFORMATION
References: Toxicity Summary Nickel Sulphate
References: Ecotoxicity Summary Ni and Ni compounds
Refer to Annexure A of this MSDS – NOTE: Please don’t print the list of references – save paper
DISCLAIMER
All information is given in good faith but without guarantee in respect of accuracy, and no responsibility is accepted for errors or omissions or the consequences thereof. It is the user's obligation to determine the conditions of safe use of the material, all risks of use of the product are therefore assumed by the user and we expressly disclaim all warranties of every kind and nature, including warranties of merchantability and fitness for a particular purpose in respect to the use or suitability of the product.
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Annexure A: List of References
References: Toxicity Summary Nickel Sulphate
Andersen A, Engeland A, Berge SR, Norseth T. (1996). Exposure to nickel compounds and smoking in relation to incidence of lung and nasal cancer among nickel refinery workers. Occup Environ Med, 53:708-13.
Anttila A, Pukkala E, Aitio A, Rantanen T, Karjalainen S. (1998). Update of cancer incidence among workers at a copper/nickel smelter and nickel. Int Arch Occup Environ Health, 71:245-50.
Benson JM, Chang IY, Cheng YS, Hahn FF, Kennedy CH, Barr EB, Maples KR, Snipes MB (1995). Particle clearance and histopathology in lungs of F344/N rats and B6C3F1 mice inhaling nickel oxide or nickel sulfate. Fundam Appl
Toxicol, 28:232-244.
Block, G. T. and M. Yeung (1982). Asthma induced by nickel. JAMA, 247(11):1600-2. Carvalho SMM and Ziemer PL. (1982). Distribution and clearance of
63Ni administered as
63NiCl2 in the rat: Intratracheal
study. Arch Environ Contam Toxicol, 11:245-248.
Clary JJ. (1975). Nickel chloride-induced metabolic changes in the rat and guinea pig. Toxicol Appl Pharmacol.; 31:55-65.
Diamond GL, Goodrum PE, Felter SP and Ruoff WL. (1998). Gastrointestinal absorption of metals. Drug Chem Toxicol, 21:223-251.
Doll et al. (International Committee on Nickel Carcinogenesis in Man (ICNCM)). (1990). Report of the International Committee on Nickel Carcinogenesis in Man. Scand J Work Environ Health, 16:1-84.
EPSL (2009a). Acute Oral Toxicity Up and Down Procedure in Rats. Testing laboratory: Eurofins Product Safety Laboratories (EPSL); Dayton, New Jersey, USA. Owner company: Nickel REACH Consortia Members. Study number: 28434. Report date: 2009-12-01.
EPSL (2009b). Acute Inhalation Toxicity Study in Rats - Defined LC50. Testing laboratory: Eurofins Product Safety Laboratories (EPSL); Dayton, New Jersey, USA. Owner company: Nickel REACH Consortia Members. Study number: 27562. Report date: 2009-09-29.
EURA (2008-2009). European Union Risk Assessment Report for Nickel Sulphate. Danish Environmental Protection Agency. Risk Assessment for Nickel Sulphate (CAS No. 7786-81-4)(EINECS No. 232-104-9) Prepared in Relation to Council Regulation (EEC) 793-93. http://www.mst.dk/English/Chemicals/Substances_and_materials/Nickel/ English JC, Parker RD, Sharma RP and Oberg SG. (1981). Toxicokinetics of nickel in rats after intratracheal administration of a soluble and insoluble form. Am Ind Hyg Assoc J, 42:486-492.
FDRL (Food & Drug Research Laboratories, Inc.) (1983). Acute Oral LD50 Study in Rats (OECD). Test Article 83-0506 (Nickel Sulfate). Testing laboratory: Food & Drug Research Laboratories, Inc. (FDRL). Report no.: FDRL Study No. 7702A. Owner company: Study conducted for NiPERA, Inc.
FDRL (Food & Drug Research Laboratories, Inc.) (1986). Dermal Contact Sensitization Study of Nickel Sulfate, Nickel Oxide, CT-243-850, and CT-243-85F. Guinea Pig Maximization Test. Testing laboratory: Food & Drug Research Laboratories, Inc. (FDRL). Report no.: 8932. Owner company: NiPERA, Inc. Report date: 1986-04-07.
Frosch PJ, Kligman AM (1976): The chamber scarification test for irritancy. Contact Dermatitis, 2:314-324.
Grimsrud TK, Berge SR, Haldorsen T, Andersen A. (2002). Exposure to different forms of nickel and risk of lung cancer. Am J Epidemiol, 156:1123-1132.
Heim KE, Bates HK, Rush RE, and Oller AR (2007). Oral carcinogenicity study with nickel sulfate hexahydrate in Fischer 344 rats. Toxicology and Applied Pharmacology. 224:126–137. Hostynek, J.J.; Dreher, F.; Nakada, T.; Schwindt, D.; Anigbogu, A.; Maibach, H.I. (2001) Human Stratum Corneum
Adsorption of Nickel Salts: Investigation of Depth Profiles by Tape Stripping in vivo. Acta Derm Venereol S212: 11-18. Ishimatsu S, Kawamoto T, Matsuno K, Kodama Y. (1995). Distribution of various nickel compounds in rat organs after oral administration. Biol Trace Elements Res, 49 (1):43–52.
Lammintausta K, Kalimo K, and Jansen CT. (1985). Experimental nickel sensitization in the guinea pig: comparison of
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different protocols. Contact Dermatitis, 12:258-262.
Larramendy ML, Popescu NC, and DiPaolo JA (1981). Induction by inorganic metal salts of sister chromatid exchange and aberrations in human and Syrian hamster cell strains. Environmental Mutagenesis, 2:597-606.
Malo JL, Cartier A, Doepner M, Nieboer E, Evans S, and Dolovich J. (1982). Occupational asthmatic caused by nickel sulfate. J Allergy Clin Immunology, 69:55-59.
Malo JL, Cartier A, Gagnon G, Evans S, and Dolovich J. (1985). Isolated late asthmatic reaction due to nickel sulphate without antibodies to nickel. Clinical Allergy, 15:95-99.
McConnell LH, Fink JN, Schlueter DP and Schmidt MG, Jr. (1973). Asthma caused by nickel sensitivity. Ann Intern Med, 78(6):888-90.
Medinsky MA, Benson JKM, Hobbs CH (1987). Lung clearance and disposition of 63
Ni in F344/N rats after intratracheal
instillation of nickel sulphate solutions. Environ Res, 43:168-178.
NTP (National Toxicology Program). (1996a). Technical Report on the toxicology and carcinogenesis studies of nickel sulfate hexahydrate (CAS NO. 10101-97-0) in F344/N rats and B6C3F1 mice (inhalation studies). National Institute of Health, Springfield, VA. Washington DC. pp. 376. Testing laboratory: NTP (National Toxicology Program). NTP Technical Report No. 454. Owner company: National Institute of Health, Springfield, VA. Washington DC. Study number: NIH Publication No. 96-3370.
Nielsen, G. D., A. E. Rohold, and K. E. Andersen. (1992). Nickel contact sensitivity in the guinea pig. Acta Derm. Venereol. 72(1):45-48.
Nielsen GD, Søderberg U, Jørgensen PJ, Templeton DM, Rasmussen SN, Andersen KE, Grandjean P (1999). Absorption and retention of nickel from drinking water in relation to food intake and nickel sensitivity. Toxicol Appl Pharmacol, 154:67-75.
Novey, H. S., M. Habib and I. D. Wells (1983). "Asthma and IgE antibodies induced by chromium and nickel salts." J Allergy Clin Immunol, 72(4):407-12.
Oller A and Erexson G (2007). Lack of micronuclei formation in bone marrow of rats after repeated oral exposure to nickel sulfate hexahydrate. Mutation research, 626(1-2):102-110.
Pang D, Burges DC, Sorahan T. (1996). Mortality study of nickel platers with special reference to cancers of the stomach and lung, 1945-93. Occup Environ Med 53, 714-7.
Rohold AE, Nielsen GD, and Andersen KE (1991). Nickel sulphate-induced contact dermatitis in the guinea pig maximization test: A dose-response study. Contact Dermatitis, 24(1):35-39.
SLI (1999). A Primary Eye Irritation Study in Rabbits with Nickel Sulphate Hexahydrate. Testing laboratory: Springborn Laboratories, Inc. Report no.: SLI Study No. 3472.2. Owner company: Study conducted for NiPERA, Inc. Report date: 1999-12-23.
SLI (2000). An oral (gavage) two-generation reproduction toxicity study in Sprague-Dawley rats with nickel sulfate hexahydrate. Testing laboratory: Springborn Laboratories, Inc. Spencerville, Ohio, USA. Report no.: SLI Study No.
Seidenari, S., Belletti, B., Mantovani, L., and Pepe, P. (1996). Nickel sulfate 5-20% aq. Does not evoke irritation on the skin of non-nickel-sensitive subjects. Contact Dermatitis, 35:260-261.
Sorahan T. (2004). Mortality of Workers at a Plant Manufacturing Nickel Alloys, 1958-2000. Occupational Medicine, 54:28-34.
Sunderman FW, Jr, Hopfer SM, Sweeny KR, Marcus AH, Most BM, Creason J (1989). Nickel absorption and kinetics in human volunteers. Proc Soc Exp Biol Med, 191:5-11.
Tanojo H, Hostynek JJ, Mountford HS, and Maibach HI. (2001). In vitro permeation of nickel salts through human stratum corneum. Acta Derm Venereol, Suppl 212:19-23.
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References: Ecotoxicity Summary Ni and Ni compounds Antunes P. (Stantec Consulting Ltd) (2007). Testing the toxicity of Ni to Lemna minor in natural waters and standard test media. Testing laboratory: Stantec Consulting Ltd., Guelph, Ontario. Report no.: 162704389. Owner company: Nickel Producers Environmental Research Association (NiPERA), Inc. Azeez PA and Banerjee DK. (1991). Nickel uptake and toxicity in cyanobacteria. Toxicological and Environmental Chemistry; 30:43-50. Babich H and Stotzky G. (1982). Toxicity of nickel to microorganisms in soil: influence of some physiochemical characteristics. Environmental Pollution; (Series A) 29:303-315. Bentley RE, Heitmuller T, Sleight III BH, and Parrish PR. (1975). Acute toxicity of nickel to bluegill (Lepomis macrochirus), rainbow trout (Salmo gairdneri), and pink shrimp (Penaeus duorarum). U. S. EPA, Criteria Branch (WH-585). Washington, D. C. Order No. WA-6-99-1414-B. Owner company: US EPA. Blaylock BG and Frank ML. (1979). A comparison of the toxicity of nickel to the developing eggs and larvae of carp (Cyprinus carpio). Bull. Environ. Contam. Toxicol.; 21(4/5):604-611. Boyd WA and Williams PJ (2003). Availability of metals to the nematode Caenophabditis elegans: Toxicity based on total concentrations in soil and extracted fractions. Env Toxicol and Chem, 22(5):1100-1106. Boyden CR (1975). Distribution of some trace metals in Poole Harbor, Dorset. Marine Pollution Bulletin, 6(12):180-187. Bryan GW and Hummerstone LG (1977). Indicators of heavy metal contamination in the looe estuary (cornwall) with particular regard to silver and lead. J Mar Bio Ass UK, 57:75-92. Calamari D, Gaggino GF, and Pacchetti G (1982). Toxicokinetics of low levels of Cd, Cr, Ni and their mixture in long-term treatment of Oncorhynchus mykiss. Chemosphere, 11(1):59-70. Chapman GA, Ota S, and Recht F (1980). Effects of water hardness on the toxicity of metals to Daphnia magna. US EPA, Corvallis, OR. 17p. Owner company: US EPA. Cokgor EU, Ozdemir S, Karahan O, Insel G, and Orhon D. (2007). Critical appraisal of respirometric methods for metal inhibition on activated sludge. Journal of Hazardous Materials, B139:332–339. De Groot AC, Peijnenburg WJGM, van den Hoop MAGT, Ritsema R, and van Veen RPM. (1998). Heavy metals in Dutch field soils: an experimental and theoretical study on equilibrium partitioning. Testing laboratory: Laboratory of Ecotoxicology, National Institute of Public Health and the Environment. Report no.: 607220001. Owner company: Laboratory of Ecotoxicology, National Institute of Public Health and the Environment. Deleebeeck NME, De Schamphelaere KAC, Muyssen BTA, De Laender F, and Janssen CR. (Ghent University) (2006). Ni toxicity to soft vs. hard water organisms: a comparison of sensitivity and bioavailability. Testing laboratory: Ghent University (UGent). Laboratory of Environmental Toxicology and Aquatic Ecology. Owner company: Nickel Producers Environmental Research Association (NiPERA), Inc. Deleebeeck NME, Muyssen BTA, De Laender F, Janssen CR, and De Schamphelaere KAC. (2007). Comparison of nickel toxicity to Cladocerans in soft versus hard surface waters. Aquatic Toxicology; 84:223-235. Testing laboratory: Laboratory of Environmental Toxicology and Aquatic Ecology, Gent University, Jozef Plateaustraat 22, Gent, Belgium. DiSalvatore M, Carratu G, and Carafa AM. (2009). Assessment of heavy metals transfer from a moderately polluted soil into the edible parts of vegetables. Journal of Food, Agriculture, and Environment; 7(2):683-688. Doelman P and Haanstra L. (1984). Short-term and long-term effects of cadmium, chromium, copper, nickel, lead and zinc on soil microbial respiration in relation to abiotic soil factors. Plant and Soil. 79:317-327. ECHA (European Chemicals Agency) (2011). Guidance on the Application of the CLP Criteria. ECHA Reference: ECHA-11-G-06-EN. Date: 04/2011. EURA (European Union Risk Assessment) (2008-2009). Danish Environmental Protection Agency. Background document in support of individual risk assessment reports of nickel compounds. Danish Environmental Protection Agency. Prepared in Relation to Council Regulation (EEC) 793-93. http://www.mst.dk/English/Chemicals/Substances_and_materials/Nickel/ Eisler R and Hennekey RJ. (1977). Acute toxicities of Cd
+2, Cr
+6, Hg
2+, Ni
2+ and Zn
2+ to estuarine macrofauna. Arch.
Environ. Contam Toxicol, 6:315-323. Ghent University/Euras (2005). NiPERA Research Project - Bioavailability and ageing of nickel in soils: Invertebrate toxicity testing. Testing laboratory: Ghent University (UGent) - Laboratory of Environmental Toxicology and Aquatic Ecology. Owner company: Nickel Producers Environmental Research Association (NiPERA), Inc. Report date: 2005-04-26. Golder Associates Ltd. (2007). Laboratory report on: Toxicity of nickel to giant kelp (Macrocysts pyrifera) and sheepshead minnow (Cyprinodon vareigatas). Testing laboratory: Golder Associated Ltd. Report no.: 06-1424-008. Owner company: Nickel Producers Environmental Research Association (NiPERA), Inc. Report date: 2007-02-15. Haanstra L and Doelman P (1991). An ecological dose-response model approach to short- and long-term effects of heavy metals on arylsulphatase activity in soil. Biology and Fertility of Soils, 11:18-23. Hoang, TC, Tomasso JR, and Klaine SJ. (2004). Influence of water quality and age on nickel toxicity to fathead minnows (Pimephales promelas). Environ. Toxicol. Chem.; 23(1):86-92. Hopfer SM, Plowman MC, Sweeney KR, Bantle JA, and Sunderman Jr. FW. (1991). Teratogenicity of Ni+2 in Xenopus laevis, assayed by the FETAX procedure. Biological Trace Element Research, 29:203-216.
Palabora Copper (Pty) Limited
Page 13 of 13
Hunt JW, Anderson BS, Phillips BM, Tjeerdema RS, Puckett HM, Stephenson M, Tucker DW, and Watson D. (2002). Acute and chronic toxicity of nickel to marine organisms: Implications for water quality criteria. Environmental Toxicology and Chemistry; 21(11):2423 - 2430. Janssen Pharmaceutica (1993). The acute toxicity of nickel chloride in the zebra fish (Brachydanio rerio). Testing laboratory: Study conducted by Janssen Pharmaceutica N. V., Beerse, Belgium. Report no.: AFBr/0015. Owner company: Nickel Producers Environmental Research Association (NiPERA), Inc. Report date: 1993-01-19. Klaine SJ and Knuteson S. (Clemson Institute of Environmental Toxicology, Clemson University) (2003). Toxicity of nickel to duckweeds. Clemson Institute of Environmental Toxicology, Clemson University, Pendleton, South Carolina. Testing laboratory: Clemson Institute of Environmental Toxicology, Clemson University. Owner company: Nickel Producers Environmental Research Association (NiPERA), Inc. Report date: 2003-12-31. Lind D, Alto K, and Chatterton S. (1978b). Regional Copper-Nickel Study: Aquatic toxicology study. Minnesota Environmental Quality Board. pp. 1-53. Ma W (1982). The influence of soil properties and worm-related factors on the concentration of heavy metals in earthworms. Pedobiologia, 24:109-119. McGeer JC, Brix KV, Skeaff JM, DeForest DK, Brigham SI, Adams WJ, and Green AS. (2003). The inverse relationship between bioconcentration factor and exposure concentration for metals: implications for hazard assessment of metals in the aquatic environment. Environ. Toxicol. Chem.; 22(5):1017-1037. Parametrix, Inc. (2007a). Toxicity of nickel in natural waters to the marine algae (Dunaliella tertiolecta). Testing laboratory: Parametrix Environmental Research Laboratory, 33972 Texas Street SW, Albany, OR 97321. Report no.: 3831-425. Owner company: Nickel Producers Environmental Research Association (NiPERA), Inc. Report date: 2007-05-14. Parametrix, Inc. (2007b). Toxicity of nickel to Neanthes arenaceodentata. Testing laboratory: Parametrix Environmental Research Laboratory, 33972 Texas Street SW, Albany, OR 97321. Report no.: 3831-457. Owner company: Nickel Producers Environmental Research Association (NiPERA), Inc. Report date: 2007-05-16. Parametrix, Inc. (2007c). Toxicity of nickel to the sand dollar, Dendraster excentricus, and the purple sea urchin, Strongylocentrotus purpuratus. Testing laboratory: Northwestern Aquatic Sciences, 3814 Yaquina Bay Rd., Newport, OR 97365. Report no.: 760-8. Owner company: Nickel Producers Environmental Research Association (NiPERA), Inc. Report date: 2007-03-07. Rothamsted Research (2005). NiPERA Research Project - Development of a predictive model of bioavailability and toxicity of nickel in soils: Plant toxicity. Testing laboratory: Rothamsted Research. Owner company: Nickel Producers Environmental Research Association (NiPERA), Inc. Report date: 2005-01-01. Schubauer-Berigan MK, Dierkes JR, Monson PD, and Ankley GT. (1993). pH-Dependent toxicity of Cd, Cu, Ni, Pb and Zn to Ceriodaphnia dubia, Pimephales Promelas, Hyalella azteca and Lumbriculus variegates. Environmental Toxicology and Chemistry, 12:1261-1266. Smolders E. (2000). The effect of NiSO4.6H2O, elemental Ni and green NiO on nitrogen transformation in soil. Final Report. Reported in conjunction with the Nickel Producers Environmental Research Association (NiPERA), Inc. 22p. Testing laboratory: University of Leuven. Report date: 2000-01-01. Stubblefield W and Van Genderen E (Parametrix, Inc) (2007). Validation of nickel biotic ligand model predictions for selected non-standard organisms. Testing laboratory: Parametrix, Inc. Owner company: Nickel Producers Environmental Research Association (NiPERA), Inc. Thakali S, Allen HE, Di Toro DM, Ponizovsky AA, Rooney GP, Zhao FJ, and McGrath SP (2006). A terrestrial biotic ligand model. 1. development and application to cu and ni toxicities to barley root elongation in soils. Environ Sci Technol, 40:7085-7093. Waegeneers N and Smolders E. (2003). Secondary poisoning of nickel to marine birds. EU Risk Assessment. Testing laboratory: Laboratory for soil and water management, KasteelPark Arenberg 20, B-3001 Heverlee-Belgium. Owner company: NiPERA, Inc. Walting HR (1983). Accumulation of seven metals by Crassostrea gigas, Crassostrea margaritacea, Perna perna, and Choromytilus meridionalis. Bull. Environ Contam Toxicol, 30:317-322. Welp G. (1999). Inhibitory effects of the total and water-soluble concentrations of nine different metals on the dehydrogenase activity of a loess soil. Biology and Fertility of Soils; 30:132-139. Willaert G and Verloo M. (1988). Biological effects of nickel species and their determination in plant and soil. Plant and Soil; 107:285-292.
p. 1
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Material Safety Data SheetDL-Dithiothreitol MSDS
Section 1: Chemical Product and Company Identification
Product Name: DL-Dithiothreitol
Catalog Codes: SLD3577
CAS#: 27565-41-9
RTECS: XO8576500 and EK1610000
TSCA: TSCA 8(b) inventory: No products were found.
CI#: Not available.
Synonym: DL-Dithiothreitol, Electrophoresis Grade;Cleland's Reagent; DL-DTT; 2,3-butanediol, 1,4-dimercapto-, DL-threo-; DL-threo-1,4-Dimercapto-2,3-butanediol; rac-Dithiothreitol
Chemical Name: Threitol, 1,4-dithio-, DL-
Chemical Formula: C4-H10-O2-S2
Contact Information:
Sciencelab.com, Inc.14025 Smith Rd.Houston, Texas 77396
US Sales: 1-800-901-7247International Sales: 1-281-441-4400
Order Online: ScienceLab.com
CHEMTREC (24HR Emergency Telephone), call:1-800-424-9300
International CHEMTREC, call: 1-703-527-3887
For non-emergency assistance, call: 1-281-441-4400
Section 2: Composition and Information on Ingredients
Composition:
Name CAS # % by Weight
{DL-}Dithiothreitol 27565-41-9 100
Toxicological Data on Ingredients: DL-Dithiothreitol LD50: Not available. LC50: Not available.
Section 3: Hazards Identification
Potential Acute Health Effects: Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation.
Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast. TERATOGENICEFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic to central nervoussystem (CNS). Repeated or prolonged exposure to the substance can produce target organs damage.
Section 4: First Aid Measures
Eye Contact:
p. 2
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15minutes. Get medical attention.
Skin Contact:In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminatedclothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention.
Serious Skin Contact:Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention.
Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention.
Serious Inhalation: Not available.
Ingestion:Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconsciousperson. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar,tie, belt or waistband.
Serious Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: May be combustible at high temperature.
Auto-Ignition Temperature: Not available.
Flash Points: CLOSED CUP: >110°C (230°F).
Flammable Limits: Not available.
Products of Combustion: These products are carbon oxides (CO, CO2), sulfur oxides (SO2, SO3...).
Fire Hazards in Presence of Various Substances:Slightly flammable to flammable in presence of heat. Non-flammable in presence of shocks.
Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Slightly explosive in presence of openflames and sparks.
Fire Fighting Media and Instructions:SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on Fire Hazards:When heated to decomposition it emits toxic fumes of Sulfur oxides, and Hydrogen Sulfide gas. As with most organic solids,fire is possible at elevated temperatures
Special Remarks on Explosion Hazards: Not available.
Section 6: Accidental Release Measures
Small Spill:Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water onthe contaminated surface and dispose of according to local and regional authority requirements.
Large Spill:Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on thecontaminated surface and allow to evacuate through the sanitary system.
Section 7: Handling and Storage
p. 3
Precautions:Keep locked up.. Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate theresidue under a fume hood. Ground all equipment containing material. Do not breathe dust. Wear suitable protective clothing.In case of insufficient ventilation, wear suitable respiratory equipment. If you feel unwell, seek medical attention and showthe label when possible. Avoid contact with skin and eyes. Keep away from incompatibles such as oxidizing agents, reducingagents, alkalis.
Storage:Keep container tightly closed. Keep container in a cool, well-ventilated area. Refrigerate. Do not store above 6°C (42.8°F).
Section 8: Exposure Controls/Personal Protection
Engineering Controls:Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommendedexposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminantsbelow the exposure limit.
Personal Protection:Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.
Exposure Limits: Not available.
Section 9: Physical and Chemical Properties
Physical state and appearance: Solid.
Odor: Not available.
Taste: Not available.
Molecular Weight: Not available.
Color: Not available.
pH (1% soln/water): Not available.
Boiling Point: Not available.
Melting Point: 42°C (107.6°F) - 44 C
Critical Temperature: Not available.
Specific Gravity: Not available.
Vapor Pressure: Not applicable.
Vapor Density: Not available.
Volatility: Not available.
Odor Threshold: Not available.
Water/Oil Dist. Coeff.: Not available.
Ionicity (in Water): Not available.
Dispersion Properties: Not available.
Solubility: Easily soluble in diethyl ether, acetone, ethanol
p. 4
Section 10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Excess heat, incompatible materials, dust generation
Incompatibility with various substances: Reactive with oxidizing agents, reducing agents, alkalis.
Corrosivity: Not available.
Special Remarks on Reactivity: Also incompatible with Alkali metals
Special Remarks on Corrosivity: Not available.
Polymerization: Will not occur.
Section 11: Toxicological Information
Routes of Entry: Inhalation. Ingestion.
Toxicity to Animals:LD50: Not available. LC50: Not available.
Chronic Effects on Humans:MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast. May cause damage to the following organs: central nervoussystem (CNS).
Other Toxic Effects on Humans: Hazardous in case of skin contact (irritant), of ingestion, of inhalation (lung irritant).
Special Remarks on Toxicity to Animals:Lethal Dose/Conc 50% Kill: LD50 [Mouse] - Route: Intraperitoneal; Dose: 169 mg/kg LD50 [Mouse] - Route: Subcutaneous;Dose: 333 mg/kg LD50 [Mouse] - Route: Intravenous; Dose: 94 mg/kg
Special Remarks on Chronic Effects on Humans: Not available.
Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: Causes skin irritation. Eyes: Causes eye irritation. Inhalation: Causes respiratory tractand mucouso membrane irritation. Ingestion: Can cause gastrointestinal tract irritation with nausea, and vomiting. May alsoaffect behavior/central nervous and cause CNS depression, convulsions, and headache. The toxicological properties of thissubstance have not been fully investigated.
Section 12: Ecological Information
Ecotoxicity: Not available.
BOD5 and COD: Not available.
Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste Disposal:Waste must be disposed of in accordance with federal, state and local environmental control regulations.
p. 5
Section 14: Transport Information
DOT Classification: Not a DOT controlled material (United States).
Identification: Not applicable.
Special Provisions for Transport: Not applicable.
Section 15: Other Regulatory Information
Federal and State Regulations: No products were found.
Other Regulations: EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.
Other Classifications:
WHMIS (Canada): Not controlled under WHMIS (Canada).
DSCL (EEC):R36/37/38- Irritating to eyes, respiratory system and skin. S24/25- Avoid contact with skin and eyes. S36/37/39- Wear suitableprotective clothing, gloves and eye/face protection.
HMIS (U.S.A.):
Health Hazard: 2
Fire Hazard: 1
Reactivity: 0
Personal Protection: E
National Fire Protection Association (U.S.A.):
Health: 2
Flammability: 1
Reactivity: 0
Specific hazard:
Protective Equipment:Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Splash goggles.
Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.
Created: 10/09/2005 05:15 PM
Last Updated: 05/21/2013 12:00 PM
The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Revision Date 22.05.2018 Version 1.6
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 21
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 822283
Product name Methanol EMPLURA®
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.
CAS-No. 67-56-1
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Chemical for synthesis
For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * 8th Floor, Godrej One,
Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079
India * Tel: 0091 22 6210 9000
Responsible Department Quality Assurance * Merck Life Science Private Limited *
e-mail: [email protected] *
Tel : +91-2267863131-6
1.4 Emergency telephone Please contact the regional company representation in your country.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 822283
Product name Methanol EMPLURA®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 21
number
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
Classification (REGULATION (EC) No 1272/2008)
Flammable liquid, Category 2, H225
Acute toxicity, Category 3, Oral, H301
Acute toxicity, Category 3, Inhalation, H331
Acute toxicity, Category 3, Dermal, H311
Specific target organ toxicity - single exposure, Category 1, Eyes, H370
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Hazard pictograms
Signal word
Danger
Hazard statements
H225 Highly flammable liquid and vapour.
H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled.
H370 Causes damage to organs (Eyes).
Precautionary statements
Prevention
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No
smoking.
P240 Ground/bond container and receiving equipment.
P280 Wear protective gloves/ protective clothing.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 822283
Product name Methanol EMPLURA®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 21
Response
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for
breathing.
P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.
Storage
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
Reduced labelling (≤125 ml)
Hazard pictograms
Signal word
Danger
Hazard statements
H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled.
H370 Causes damage to organs (Eyes).
Precautionary statements
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P280 Wear protective gloves/ protective clothing.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.
CAS-No. 67-56-1
2.3 Other hazards
None known.
SECTION 3. Composition/information on ingredients
3.1 Substance
Formula CH₃OH CH₄O (Hill)
EC-No. 200-659-6
Molar mass 32.04 g/mol
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 822283
Product name Methanol EMPLURA®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 4 of 21
Hazardous components (REGULATION (EC) No 1272/2008)
Chemical name (Concentration)
CAS-No. Registration number Classification
Methanol (<= 100 % )
Substance does not meet the criteria for PBT or vPvB according to Regulation (EC) No 1907/2006, Annex XIII.
67-56-1 *)
Flammable liquid, Category 2, H225
Acute toxicity, Category 3, H301
Acute toxicity, Category 3, H331
Acute toxicity, Category 3, H311
Specific target organ toxicity - single exposure, Category 1, H370
*) A registration number is not available for this substance as the substance or its use are exempted from registration according to Article
2 REACH Regulation (EC) No 1907/2006, the annual tonnage does not require a registration or the registration is envisaged for a later
registration deadline.
For the full text of the H-Statements mentioned in this Section, see Section 16.
3.2 Mixture
Not applicable
SECTION 4. First aid measures
4.1 Description of first aid measures
General advice
First aider needs to protect himself.
After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately apply
artificial respiration, if necessary also oxygen.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower. Call a physician immediately.
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 822283
Product name Methanol EMPLURA®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 5 of 21
After swallowing: fresh air. Make victim drink ethanol (e.g. 1 drinking glass of a 40% alcoholic
beverage). Call a doctor immediately (mention methanol ingestion). Only in exceptional cases, if
no medical care is available within one hour, induce vomiting (only in fully conscious persons)
and make victim drink ethanol again (approx. 0.3 ml of a 40% alcoholic beverage/kg body
weight/hour).
4.2 Most important symptoms and effects, both acute and delayed
irritant effects, Drowsiness, Dizziness, narcosis, agitation, spasms, inebriation, Nausea,
Vomiting, Headache, blindness, Impairment of vision, Coma
Drying-out effect resulting in rough and chapped skin.
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SECTION 5. Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Foam, Carbon dioxide (CO2), Dry powder, Water
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Combustible.
Vapours are heavier than air and may spread along floors.
Forms explosive mixtures with air at ambient temperatures.
Pay attention to flashback.
Development of hazardous combustion gases or vapours possible in the event of fire.
5.3 Advice for firefighters
Special protective equipment for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 822283
Product name Methanol EMPLURA®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 6 of 21
Further information
Remove container from danger zone and cool with water. Suppress (knock down)
gases/vapours/mists with a water spray jet. Prevent fire extinguishing water from contaminating
surface water or the ground water system.
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapours, aerosols. Avoid substance
contact. Ensure adequate ventilation. Keep away from heat and sources of ignition. Evacuate the
danger area, observe emergency procedures, consult an expert.
Advice for emergency responders:
Protective equipment see section 8.
6.2 Environmental precautions
Do not let product enter drains. Risk of explosion.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see
sections 7 and 10). Take up carefully with liquid-absorbent material (e.g. Chemizorb®). Dispose
of properly. Clean up affected area.
6.4 Reference to other sections
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handling
Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Observe label precautions.
Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition. Take precautionary
measures against static discharge.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 822283
Product name Methanol EMPLURA®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 7 of 21
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and
face after working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and
sources of ignition. Keep locked up or in an area accessible only to qualified or authorised
persons.
Recommended storage temperature see product label.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
Methanol (67-56-1)
IN OEL Skin designation: Can be absorbed through the skin.
Short Term Exposure
Limit (STEL):
250 ppm
310 mg/m³
Time Weighted Average
(TWA):
200 ppm
260 mg/m³
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 822283
Product name Methanol EMPLURA®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 8 of 21
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Eye/face protection
Safety glasses
Hand protection
full contact:
Glove material: butyl-rubber
Glove thickness: 0.7 mm
Break through time: > 480 min
splash contact:
Glove material: Viton (R)
Glove thickness: 0.70 mm
Break through time: > 120 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 898 Butoject® (full contact), KCL
890 Vitoject® (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Other protective equipment
Flame retardant antistatic protective clothing.
Respiratory protection
required when vapours/aerosols are generated.
Recommended Filter type: Filter AX (EN 371)
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 822283
Product name Methanol EMPLURA®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 9 of 21
Environmental exposure controls
Do not let product enter drains.
Risk of explosion.
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
Form liquid
Colour colourless
Odour characteristic
pungent
Odour Threshold 10 - 20000 ppm
pH No information available.
Melting point -98 °C
Boiling point/boiling range 64.5 °C
at 1,013 hPa
Flash point 9.7 °C
Method: Tested according to Directive 92/69/EEC.
Evaporation rate 6.3
Reference substance: Diethylether
1.9
Reference substance: n-butyl acetate
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 822283
Product name Methanol EMPLURA®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 10 of 21
Flammability (solid, gas) No information available.
Lower explosion limit 5.5 %(V)
Upper explosion limit 44 %(V)
Vapour pressure 128 hPa
at 20 °C
Relative vapour density 1.11
Density 0.792 g/cm3
at 20 °C
Relative density No information available.
Water solubility completely miscible
Partition coefficient: n-
octanol/water
log Pow: -0.77
(experimental)
(Lit.) Bioaccumulation is not expected.
Auto-ignition temperature No information available.
Decomposition temperature Distillable in an undecomposed state at normal pressure.
Viscosity, dynamic 0.597 mPa.s
at 20 °C
Explosive properties Not classified as explosive.
Oxidizing properties none
9.2 Other data
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 822283
Product name Methanol EMPLURA®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 11 of 21
Ignition temperature 420 °C
at1,013 hPa
Method: DIN 51794
Minimum ignition energy 0.14 mJ
Conductivity < 1 µS/cm
SECTION 10. Stability and reactivity
10.1 Reactivity
Vapours may form explosive mixture with air.
10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.3 Possibility of hazardous reactions
Risk of explosion with:
Oxidizing agents, perchloric acid, perchlorates, salts of oxyhalogenic acids, chromium(VI) oxide,
halogen oxides, nitrogen oxides, nonmetallic oxides, chromosulfuric acid, chlorates, hydrides, zinc
diethyl, halogens, powdered magnesium, hydrogen peroxide, Nitric acid, sulphuric acid,
permanganic acid, sodium hypochlorite
Exothermic reaction with:
acid halides, Acid anhydrides, Reducing agents, acids, Bromine, Chlorine, Chloroform,
magnesium, tetrachloromethane, CYANURIC CHLORIDE
Risk of ignition or formation of inflammable gases or vapours with:
Fluorine, Oxides of phosphorus, Raney-nickel
Generates dangerous gases or fumes in contact with:
Alkaline earth metals, Alkali metals
10.4 Conditions to avoid
Warming.
10.5 Incompatible materials
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 822283
Product name Methanol EMPLURA®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 12 of 21
various plastics, magnesium, zinc alloys
10.6 Hazardous decomposition products
no information available
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Acute oral toxicity
LDLO human: 143 mg/kg
(RTECS)
Acute toxicity estimate: 100.1 mg/kg
Expert judgement
Symptoms: Nausea, Vomiting
Acute inhalation toxicity
LC50 Rat: 131.25 mg/l; 4 h ; vapour
(ECHA)
Symptoms: Irritation symptoms in the respiratory tract.
Acute dermal toxicity
LD50 Rabbit: ca. 17,100 mg/kg
(External MSDS)
Acute toxicity estimate : 300.1 mg/kg
Expert judgement
Skin irritation
Rabbit
Result: No skin irritation
(ECHA)
Drying-out effect resulting in rough and chapped skin.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 822283
Product name Methanol EMPLURA®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 13 of 21
Eye irritation
Rabbit
Result: No eye irritation
(ECHA)
Irritations of mucous membranes
Sensitisation
Sensitisation test: Guinea pig
Result: negative
Method: OECD Test Guideline 406
Germ cell mutagenicity
Genotoxicity in vivo
Micronucleus test
Mouse
male and female
Intraperitoneal injection
Bone marrow
Result: negative
Method: OECD Test Guideline 474
Genotoxicity in vitro
Ames test
Salmonella typhimurium
Result: negative
Method: OECD Test Guideline 471
In vitro mammalian cell gene mutation test
Result: negative
Method: OECD Test Guideline 476
Carcinogenicity
This information is not available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 822283
Product name Methanol EMPLURA®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 14 of 21
Reproductive toxicity
This information is not available.
Teratogenicity
This information is not available.
CMR effects
Carcinogenicity:
Did not show carcinogenic effects in animal experiments.
Mutagenicity:
Based on available data the classification criteria are not met.
Teratogenicity:
Based on available data the classification criteria are not met.
Reproductive toxicity:
Based on available data the classification criteria are not met.
Specific target organ toxicity - single exposure
Causes damage to organs.
Target Organs: Eyes
Specific target organ toxicity - repeated exposure
This information is not available.
Repeated dose toxicity
Rat
male and female
Inhalation
vapour
28 d
daily
NOAEL: 6.66 mg/l
OECD Test Guideline 412
Subacute toxicity
Rat
male and female
Inhalation
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 822283
Product name Methanol EMPLURA®
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Page 15 of 21
365 d
daily
NOAEL: 0.13 mg/l
LOAEL: 1.3 mg/l
OECD Test Guideline 453
Aspiration hazard
This information is not available.
11.2 Further information
Systemic effects:
acidosis, drop in blood pressure, agitation, spasms, inebriation, Dizziness, Drowsiness,
Headache, Impairment of vision, blindness, narcosis, Coma
Symptoms may be delayed.
Damage to:
Liver, Kidney, Cardiac, Irreversible damage of the optical nerve.
Other dangerous properties can not be excluded.
This substance should be handled with particular care.
SECTION 12. Ecological information
12.1 Toxicity
Toxicity to fish
flow-through test LC50 Lepomis macrochirus (Bluegill sunfish): 15,400 mg/l; 96 h
US-EPA
Toxicity to daphnia and other aquatic invertebrates
EC5 E.sulcatum: > 10,000 mg/l; 72 h
(Lit.)
EC50 Daphnia magna (Water flea): > 10,000 mg/l; 48 h
(IUCLID)
Toxicity to algae
static test EC50 Pseudokirchneriella subcapitata (green algae): ca. 22,000 mg/l; 96 h
OECD Test Guideline 201
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 822283
Product name Methanol EMPLURA®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 16 of 21
Toxicity to bacteria
EC5 Pseudomonas fluorescens: 6,600 mg/l; 16 h
(IUCLID)
static test IC50 activated sludge: > 1,000 mg/l; 3 h
Analytical monitoring: yes
OECD Test Guideline 209
Toxicity to fish (Chronic toxicity)
NOEC Oryzias latipes (Orange-red killifish): 7,900 mg/l; 200 h
(External MSDS)
12.2 Persistence and degradability
Biodegradability
99 %; 30 d
OECD Test Guideline 301D
Readily biodegradable
Biochemical Oxygen Demand (BOD)
600 - 1,120 mg/g (5 d)
(IUCLID)
Chemical Oxygen Demand (COD)
1,420 mg/g
(IUCLID)
Theoretical oxygen demand (ThOD)
1,500 mg/g
(Lit.)
Ratio BOD/ThBOD
BOD5 76 %
Closed Bottle test
12.3 Bioaccumulative potential
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 822283
Product name Methanol EMPLURA®
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Page 17 of 21
Partition coefficient: n-octanol/water
log Pow: -0.77
(experimental)
(Lit.) Bioaccumulation is not expected.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
Substance does not meet the criteria for PBT or vPvB according to Regulation (EC) No
1907/2006, Annex XIII.
12.6 Other adverse effects
Surface tension
22.6 mN/m
at 20 °C
Stability in water
2.2 yr
reaction with hydroxyl radicals (IUCLID)
Discharge into the environment must be avoided.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 822283
Product name Methanol EMPLURA®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 18 of 21
SECTION 13. Disposal considerations
Waste treatment methods
Waste material must be disposed of in accordance with the national and local regulations. Leave
chemicals in original containers. No mixing with other waste. Handle uncleaned containers like
the product itself.
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 UN number UN 1230
14.2 Proper shipping name METHANOL
14.3 Class 3 (6.1)
14.4 Packing group II
14.5 Environmentally hazardous --
14.6 Special precautions for
user
yes
Tunnel restriction code D/E
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)
14.1 UN number UN 1230
14.2 Proper shipping name METHANOL
14.3 Class 3 (6.1)
14.4 Packing group II
14.5 Environmentally hazardous --
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 822283
Product name Methanol EMPLURA®
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Page 19 of 21
14.6 Special precautions for
user
no
Sea transport (IMDG)
14.1 UN number UN 1230
14.2 Proper shipping name METHANOL
14.3 Class 3 (6.1)
14.4 Packing group II
14.5 Environmentally hazardous --
14.6 Special precautions for
user
yes
EmS F-E S-D
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National legislation
Storage class 3
15.2 Chemical safety assessment
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Full text of H-Statements referred to under sections 2 and 3.
H225 Highly flammable liquid and vapour.
H301 Toxic if swallowed.
H311 Toxic in contact with skin.
H331 Toxic if inhaled.
H370 Causes damage to organs.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 822283
Product name Methanol EMPLURA®
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Page 20 of 21
Training advice
Provide adequate information, instruction and training for operators.
Labelling
Hazard pictograms
Signal word
Danger
Hazard statements
H225 Highly flammable liquid and vapour.
H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled.
H370 Causes damage to organs (Eyes).
Precautionary statements
Prevention
P210 Keep away from heat/sparks/open flames/hot surfaces. No smoking.
P240 Ground/bond container and receiving equipment.
P280 Wear protective gloves/ protective clothing.
Response
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for
breathing.
P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.
Storage
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
Key or legend to abbreviations and acronyms used in the safety data sheet
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 822283
Product name Methanol EMPLURA®
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 21 of 21
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Revision Date 15.06.2017 Version 1.6
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 19
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 100063
Product name Acetic acid (glacial) 100% anhydrous for analysis EMSURE®
ACS,ISO,Reag. Ph Eur
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.
CAS-No. 64-19-7
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Reagent for analysis, Chemical production
For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * 8th Floor, Godrej One,
Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079
India * Tel: 0091 22 6210 9000
Responsible Department Quality Assurance * Merck Life Science Private Limited *
e-mail: [email protected] *
Tel : +91-2267863131-6
1.4 Emergency telephone
number
Please contact the regional company representation in your country.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100063
Product name Acetic acid (glacial) 100% anhydrous for analysis EMSURE®
ACS,ISO,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 19
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
Classification (REGULATION (EC) No 1272/2008)
Flammable liquid, Category 3, H226
Corrosive to metals, Category 1, H290
Skin corrosion, Category 1A, H314
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Hazard pictograms
Signal word
Danger
Hazard statements
H226 Flammable liquid and vapour.
H290 May be corrosive to metals.
H314 Causes severe skin burns and eye damage.
Precautionary statements
Prevention
P210 Keep away from heat.
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
Response
P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100063
Product name Acetic acid (glacial) 100% anhydrous for analysis EMSURE®
ACS,ISO,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 19
P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.
Reduced labelling (≤125 ml)
Hazard pictograms
Signal word
Danger
Hazard statements
H314 Causes severe skin burns and eye damage.
Precautionary statements
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing.
P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.
Contains: acetic acid
CAS-No. 64-19-7
2.3 Other hazards
None known.
SECTION 3. Composition/information on ingredients
3.1 Substance
Formula CH₃COOH C₂H₄O₂ (Hill)
EC-No. 200-580-7
Molar mass 60.05 g/mol
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100063
Product name Acetic acid (glacial) 100% anhydrous for analysis EMSURE®
ACS,ISO,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 4 of 19
Hazardous components (REGULATION (EC) No 1272/2008)
Chemical name (Concentration)
CAS-No. Registration number Classification
acetic acid (<= 100 % )
Substance does not meet the criteria for PBT or vPvB according to Regulation (EC) No 1907/2006, Annex XIII.
64-19-7 *)
Flammable liquid, Category 3, H226
Corrosive to metals, Category 1, H290
Skin corrosion, Category 1A, H314
*) A registration number is not available for this substance as the substance or its use are exempted from registration according to Article
2 REACH Regulation (EC) No 1907/2006, the annual tonnage does not require a registration or the registration is envisaged for a later
registration deadline.
For the full text of the H-Statements mentioned in this Section, see Section 16.
3.2 Mixture
Not applicable
SECTION 4. First aid measures
4.1 Description of first aid measures
General advice
First aider needs to protect himself.
After inhalation: fresh air. Call in physician.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower. Call a physician immediately.
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove
contact lenses.
After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of
perforation). Call a physician immediately. Do not attempt to neutralise.
4.2 Most important symptoms and effects, both acute and delayed
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100063
Product name Acetic acid (glacial) 100% anhydrous for analysis EMSURE®
ACS,ISO,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 5 of 19
Irritation and corrosion, bronchitis, Shortness of breath, gastric spasms, Nausea, Vomiting,
Circulatory collapse, shock
Risk of corneal clouding.
Risk of blindness!
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SECTION 5. Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Water, Carbon dioxide (CO2), Foam, Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Combustible.
Vapours are heavier than air and may spread along floors.
Forms explosive mixtures with air at elevated temperatures.
Development of hazardous combustion gases or vapours possible in the event of fire.
Fire may cause evolution of:
Acetic acid vapours
5.3 Advice for firefighters
Special protective equipment for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.
Further information
Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing
water from contaminating surface water or the ground water system. Remove container from
danger zone and cool with water.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100063
Product name Acetic acid (glacial) 100% anhydrous for analysis EMSURE®
ACS,ISO,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 6 of 19
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapours, aerosols. Avoid substance
contact. Ensure adequate ventilation. Keep away from heat and sources of ignition. Evacuate the
danger area, observe emergency procedures, consult an expert.
Advice for emergency responders:
Protective equipment see section 8.
6.2 Environmental precautions
Do not let product enter drains. Risk of explosion.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills.
Observe possible material restrictions (see sections 7 and 10).
Take up with liquid-absorbent and neutralising material (e.g. Chemizorb® H⁺, Merck Art. No.
101595). Dispose of properly. Clean up affected area.
6.4 Reference to other sections
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handling
Observe label precautions.
Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition. Take precautionary
measures against static discharge.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and
face after working with substance.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100063
Product name Acetic acid (glacial) 100% anhydrous for analysis EMSURE®
ACS,ISO,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 7 of 19
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Keep away from heat and sources of ignition. Keep container tightly closed in a dry and well-
ventilated place.
Recommended storage temperature see product label.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
acetic acid (64-19-7)
IN OEL Short Term Exposure
Limit (STEL):
15 ppm
37 mg/m³
Time Weighted Average
(TWA):
10 ppm
25 mg/m³
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100063
Product name Acetic acid (glacial) 100% anhydrous for analysis EMSURE®
ACS,ISO,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 8 of 19
Eye/face protection
Tightly fitting safety goggles
Hand protection
full contact:
Glove material: butyl-rubber
Glove thickness: 0.7 mm
Break through time: > 480 min
splash contact:
Glove material: natural latex
Glove thickness: 0.6 mm
Break through time: > 30 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 898 Butoject® (full contact), KCL
706 Lapren® (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Other protective equipment
Flame retardant antistatic protective clothing.
Respiratory protection
required when vapours/aerosols are generated.
Recommended Filter type: filter E-(P2)
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100063
Product name Acetic acid (glacial) 100% anhydrous for analysis EMSURE®
ACS,ISO,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 9 of 19
Environmental exposure controls
Do not let product enter drains.
Risk of explosion.
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
Form liquid
Colour colourless
Odour stinging
Odour Threshold 0.2 - 100.1 ppm
pH 2.5
at 50 g/l
20 °C
Melting point 17 °C
Boiling point/boiling range 116 - 118 °C
at 1,013 hPa
Flash point 39 °C
Method: c.c.
Evaporation rate No information available.
Flammability (solid, gas) Not applicable
Lower explosion limit 4 %(V)
Upper explosion limit 19.9 %(V)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100063
Product name Acetic acid (glacial) 100% anhydrous for analysis EMSURE®
ACS,ISO,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 10 of 19
Vapour pressure 15.4 hPa
at 20 °C
Relative vapour density 2.07
Density 1.05 g/cm3
at 20 °C
Relative density No information available.
Water solubility 602.9 g/l
at 25 °C
Partition coefficient: n-
octanol/water
log Pow: -0.17 (25 °C)
(experimental)
(ECHA) Bioaccumulation is not expected.
Auto-ignition temperature No information available.
Decomposition temperature Distillable in an undecomposed state at normal pressure.
Viscosity, dynamic 1.22 mPa.s
at 20 °C
Explosive properties Not classified as explosive.
Oxidizing properties none
9.2 Other data
Ignition temperature 485 °C
Viscosity, kinematic 1.17 mm2/s
at 20 °C
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100063
Product name Acetic acid (glacial) 100% anhydrous for analysis EMSURE®
ACS,ISO,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 11 of 19
Corrosion May be corrosive to metals.
SECTION 10. Stability and reactivity
10.1 Reactivity
Vapour/air-mixtures are explosive at intense warming.
10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.3 Possibility of hazardous reactions
Risk of explosion with:
peroxi compounds, perchloric acid, fuming sulfuric acid, phosphorus halides, hydrogen peroxide,
chromium(VI) oxide, potassium permanganate, Peroxides, Strong oxidizing agents
Risk of ignition or formation of inflammable gases or vapours with:
Metals, Iron, Zinc, magnesium, Mild steel
Possible formation of:
Hydrogen
Violent reactions possible with:
strong alkalis, anhydrides, Aldehydes, alkali hydroxides, nonmetallic halides, ethanolamine,
Acetaldehyde, Alcohols, halogen-halogen compounds, chlorosulfonic acid, chromosulfuric acid,
Potassium hydroxide, Nitric acid
10.4 Conditions to avoid
Temperatures < 17 °C.
Heating.
10.5 Incompatible materials
various metals
10.6 Hazardous decomposition products
in the event of fire: See section 5.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100063
Product name Acetic acid (glacial) 100% anhydrous for analysis EMSURE®
ACS,ISO,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 12 of 19
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Acute oral toxicity
LD50 Rat: 3,310 mg/kg
(RTECS)
Symptoms: If ingested, severe burns of the mouth and throat, as well as a danger of perforation
of the oesophagus and the stomach., Nausea, Vomiting, Risk of aspiration upon vomiting.,
Pulmonary failure possible after aspiration of vomit.
Acute inhalation toxicity
LCLO Rat: 39.95 mg/l; 4 h
(RTECS)
Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of
respiratory tract, Pneumonia, bronchitis, Inhalation may lead to the formation of oedemas in the
respiratory tract., Symptoms may be delayed.
Acute dermal toxicity
This information is not available.
Skin irritation
Rabbit
Result: Causes burns.
(IUCLID)
Causes severe burns.
Eye irritation
Rabbit
Result: Causes burns.
(IUCLID)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100063
Product name Acetic acid (glacial) 100% anhydrous for analysis EMSURE®
ACS,ISO,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 13 of 19
Causes serious eye damage.
Risk of blindness!
Risk of corneal clouding.
Sensitisation
This information is not available.
Germ cell mutagenicity
Genotoxicity in vitro
Ames test
Salmonella typhimurium
Result: negative
Method: OECD Test Guideline 471
Mutagenicity (mammal cell test): chromosome aberration.
Result: negative
Method: OECD Test Guideline 473
Carcinogenicity
This information is not available.
Reproductive toxicity
This information is not available.
Teratogenicity
Did not show teratogenic effects in animal experiments. (IUCLID)
Specific target organ toxicity - single exposure
This information is not available.
Specific target organ toxicity - repeated exposure
This information is not available.
Aspiration hazard
This information is not available.
11.2 Further information
Systemic effects:
Shortness of breath, gastric spasms, shock, Circulatory collapse, acidosis
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100063
Product name Acetic acid (glacial) 100% anhydrous for analysis EMSURE®
ACS,ISO,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 14 of 19
Possible damages:
Damage to:
Kidney
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
SECTION 12. Ecological information
12.1 Toxicity
Toxicity to fish
semi-static test LC50 Oncorhynchus mykiss (rainbow trout): > 300.8 mg/l; 96 h
OECD Test Guideline 203
Toxicity to daphnia and other aquatic invertebrates
EC5 E.sulcatum: 78 mg/l; 72 h
neutral (maximum permissible toxic concentration) (Lit.)
EC50 Daphnia magna (Water flea): 47 mg/l; 24 h
(Lit.)
Toxicity to algae
IC5 Scenedesmus quadricauda (Green algae): 4,000 mg/l; 16 h
(maximum permissible toxic concentration) (Lit.)
Toxicity to bacteria
EC5 Pseudomonas putida: 2,850 mg/l; 16 h
neutral (maximum permissible toxic concentration) (Lit.)
microtox test EC50 Photobacterium phosphoreum: 11 mg/l; 15 min
(IUCLID)
12.2 Persistence and degradability
Biodegradability
99 %; 30 d
OECD Test Guideline 301D
(HSDB)
Readily biodegradable
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100063
Product name Acetic acid (glacial) 100% anhydrous for analysis EMSURE®
ACS,ISO,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 15 of 19
95 %; 5 d
OECD Test Guideline 302B
Readily eliminated from water
Biochemical Oxygen Demand (BOD)
880 mg/g (5 d)
(Lit.)
Ratio BOD/ThBOD
BOD5 76 %
(IUCLID)
12.3 Bioaccumulative potential
Partition coefficient: n-octanol/water
log Pow: -0.17 (25 °C)
(experimental)
(ECHA) Bioaccumulation is not expected.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
Substance does not meet the criteria for PBT or vPvB according to Regulation (EC) No
1907/2006, Annex XIII.
12.6 Other adverse effects
Additional ecological information
Biological effects:
Harmful effect due to pH shift. Caustic even in diluted form.
Discharge into the environment must be avoided.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100063
Product name Acetic acid (glacial) 100% anhydrous for analysis EMSURE®
ACS,ISO,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 16 of 19
SECTION 13. Disposal considerations
Waste treatment methods
Waste material must be disposed of in accordance with the national and local regulations. Leave
chemicals in original containers. No mixing with other waste. Handle uncleaned containers like
the product itself.
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 UN number UN 2789
14.2 Proper shipping name ACETIC ACID, GLACIAL
14.3 Class 8 (3)
14.4 Packing group II
14.5 Environmentally hazardous --
14.6 Special precautions for
user
yes
Tunnel restriction code D/E
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)
14.1 UN number UN 2789
14.2 Proper shipping name ACETIC ACID, GLACIAL
14.3 Class 8 (3)
14.4 Packing group II
14.5 Environmentally hazardous --
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100063
Product name Acetic acid (glacial) 100% anhydrous for analysis EMSURE®
ACS,ISO,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 17 of 19
14.6 Special precautions for
user
no
Sea transport (IMDG)
14.1 UN number UN 2789
14.2 Proper shipping name ACETIC ACID, GLACIAL
14.3 Class 8 (3)
14.4 Packing group II
14.5 Environmentally hazardous --
14.6 Special precautions for
user
yes
EmS F-E S-C
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National legislation
Storage class 3
15.2 Chemical safety assessment
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Full text of H-Statements referred to under sections 2 and 3.
H226 Flammable liquid and vapour.
H290 May be corrosive to metals.
H314 Causes severe skin burns and eye damage.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100063
Product name Acetic acid (glacial) 100% anhydrous for analysis EMSURE®
ACS,ISO,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 18 of 19
Training advice
Provide adequate information, instruction and training for operators.
Labelling
Hazard pictograms
Signal word
Danger
Hazard statements
H226 Flammable liquid and vapour.
H290 May be corrosive to metals.
H314 Causes severe skin burns and eye damage.
Precautionary statements
Prevention
P210 Keep away from heat.
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
Response
P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.
Contains: acetic acid
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100063
Product name Acetic acid (glacial) 100% anhydrous for analysis EMSURE®
ACS,ISO,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 19 of 19
The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
SAFETY DATA SHEETCreation Date 21-Sep-2009 Revision Date 18-Jan-2018 Revision Number 4
1. IdentificationProduct Name Trifluoroacetic acid
Cat No. : A116-05AMP; A116-1AMP; A116-10X1AMP; A116-2AMP; A116-50
CAS-No 76-05-1Synonyms TFA; Trifluoroethanoic acid; Perfluoroacetic acid
Recommended Use Laboratory chemicals.Uses advised against Not for food, drug, pesticide or biocidal product use
Details of the supplier of the safety data sheet
Emergency Telephone Number CHEMTRECÒ, Inside the USA: 800-424-9300CHEMTRECÒ, Outside the USA: 001-703-527-3887
2. Hazard(s) identificationClassification This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)
Label Elements
Signal WordDanger
Hazard StatementsMay be corrosive to metalsHarmful if inhaledCauses severe skin burns and eye damageMay cause respiratory irritationMay cause drowsiness or dizzinessMay cause damage to organs through prolonged or repeated exposure
Company Fisher ScientificOne Reagent LaneFair Lawn, NJ 07410Tel: (201) 796-7100
Acute Inhalation Toxicity - Vapors Category 4Skin Corrosion/irritation Category 1 ASerious Eye Damage/Eye Irritation Category 1Specific target organ toxicity (single exposure) Category 3Target Organs - Respiratory system, Central nervous system (CNS).Specific target organ toxicity - (repeated exposure) Category 2Target Organs - Kidney, Liver.
Corrosive to metals Category 1
______________________________________________________________________________________________
Page 1 / 7
______________________________________________________________________________________________Trifluoroacetic acid Revision Date 18-Jan-2018
Precautionary StatementsPreventionUse only outdoors or in a well-ventilated areaDo not breathe dust/fume/gas/mist/vapors/sprayWash face, hands and any exposed skin thoroughly after handlingWear protective gloves/protective clothing/eye protection/face protectionResponseImmediately call a POISON CENTER or doctor/physicianInhalationIF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathingSkinIF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/showerWash contaminated clothing before reuseEyesIF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsingIngestionIF SWALLOWED: Rinse mouth. DO NOT induce vomitingStorageStore locked upStore in a well-ventilated place. Keep container tightly closedDisposalDispose of contents/container to an approved waste disposal plantHazards not otherwise classified (HNOC) Harmful to aquatic life with long lasting effects
3. Composition/Information on Ingredients
Component CAS-No Weight %Trifluoroacetic acid 76-05-1 >95
4. First-aid measures
Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.Immediate medical attention is required.
Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Immediate medicalattention is required.
Inhalation Move to fresh air. Do not use mouth-to-mouth method if victim ingested or inhaled thesubstance; give artificial respiration with the aid of a pocket mask equipped with a one-wayvalve or other proper respiratory medical device. Immediate medical attention is required. Ifnot breathing, give artificial respiration.
Ingestion Do not induce vomiting. Call a physician or Poison Control Center immediately.
Most important symptoms andeffects
Causes burns by all exposure routes. Product is a corrosive material. Use of gastriclavage or emesis is contraindicated. Possible perforation of stomach or esophagus should
______________________________________________________________________________________________
Page 2 / 7
______________________________________________________________________________________________Trifluoroacetic acid Revision Date 18-Jan-2018
be investigated: Ingestion causes severe swelling, severe damage to the delicate tissueand danger of perforation
Notes to Physician Treat symptomatically
5. Fire-fighting measuresSuitable Extinguishing Media CO 2, dry chemical, dry sand, alcohol-resistant foam.
Unsuitable Extinguishing Media No information available
Flash Point No information availableMethod - No information available
Autoignition Temperature No information availableExplosion Limits
Upper No data availableLower No data availableSensitivity to Mechanical Impact No information availableSensitivity to Static Discharge No information available
Specific Hazards Arising from the ChemicalCorrosive Material. Causes severe burns by all exposure routes.
Hazardous Combustion ProductsCarbon monoxide (CO) Carbon dioxide (CO2) Hydrogen fluorideProtective Equipment and Precautions for FirefightersAs in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and fullprotective gear. Thermal decomposition can lead to release of irritating gases and vapors.
NFPA
6. Accidental release measuresPersonal Precautions Use personal protective equipment. Ensure adequate ventilation. Evacuate personnel to
safe areas. Keep people away from and upwind of spill/leak.Environmental Precautions Should not be released into the environment. See Section 12 for additional ecological
information. Do not flush into surface water or sanitary sewer system.
Methods for Containment and CleanUp
Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.
7. Handling and storageHandling Use only under a chemical fume hood. Wear personal protective equipment. Do not get in
eyes, on skin, or on clothing. Do not breathe vapors/dust. Do not ingest.
Storage Keep containers tightly closed in a dry, cool and well-ventilated place. Corrosives area. Donot store in metal containers.
8. Exposure controls / personal protectionExposure Guidelines This product does not contain any hazardous materials with occupational exposure
limitsestablished by the region specific regulatory bodies.
Health3
Flammability0
Instability0
Physical hazardsN/A
Engineering Measures Use only under a chemical fume hood. Ensure that eyewash stations and safety showersare close to the workstation location.
______________________________________________________________________________________________
Page 3 / 7
______________________________________________________________________________________________Trifluoroacetic acid Revision Date 18-Jan-2018
9. Physical and chemical propertiesPhysical State LiquidAppearance Clear, ColorlessOdor pungentOdor Threshold No information availablepH 0.45 100 g/L aq.solMelting Point/Range -15 °C / 5 °FBoiling Point/Range 72 °C / 161.6 °F @ 760 mmHgFlash Point No information availableEvaporation Rate No information availableFlammability (solid,gas) Not applicableFlammability or explosive limits
Upper No data availableLower No data available
Vapor Pressure 107 mbar @ 25 °CVapor Density 3.9Specific Gravity 1.535Solubility Miscible with waterPartition coefficient; n-octanol/water No data availableAutoignition Temperature No information availableDecomposition Temperature No information availableViscosity 0.813 cP at 25 °CMolecular Formula C2 H F3 O2Molecular Weight 114.02
10. Stability and reactivity
Reactive Hazard None known, based on information available
Stability Hygroscopic.
Conditions to Avoid Incompatible products. Exposure to moist air or water. Exposure to light. Excess heat.
Incompatible Materials Strong oxidizing agents, Reducing agents, Acids, Strong bases, Metals, Amines
Hazardous Decomposition Products Carbon monoxide (CO), Carbon dioxide (CO2), Hydrogen fluoride
Hazardous Polymerization Hazardous polymerization does not occur.
Hazardous Reactions None under normal processing.
11. Toxicological informationAcute Toxicity
Product Information
Personal Protective Equipment
Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described byOSHA's eye and face protection regulations in 29 CFR 1910.133 or European StandardEN166.
Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure.
Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European StandardEN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator ifexposure limits are exceeded or if irritation or other symptoms are experienced.
Hygiene Measures
______________________________________________________________________________________________
Page 4 / 7
Handle in accordance with good industrial hygiene and safety practice.
______________________________________________________________________________________________Trifluoroacetic acid Revision Date 18-Jan-2018
Component InformationComponent LD50 Oral LD50 Dermal LC50 Inhalation
Trifluoroacetic acid 200-400 mg/kg (rat) Not listed 10 mg/L/2h (rat)Toxicologically SynergisticProducts
No information available
Delayed and immediate effects as well as chronic effects from short and long-term exposure
Irritation Causes severe burns by all exposure routes
Sensitization No information available
Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.
Component CAS-No IARC NTP ACGIH OSHA MexicoTrifluoroacetic acid 76-05-1 Not listed Not listed Not listed Not listed Not listed
Mutagenic Effects Not mutagenic in AMES Test
Reproductive Effects No information available.
Developmental Effects No information available.
Teratogenicity No information available.
STOT - single exposure Respiratory system Central nervous system (CNS)STOT - repeated exposure Kidney Liver
Aspiration hazard No information available
Symptoms / effects,both acute anddelayed
Product is a corrosive material. Use of gastric lavage or emesis is contraindicated.Possible perforation of stomach or esophagus should be investigated: Ingestion causessevere swelling, severe damage to the delicate tissue and danger of perforation
Endocrine Disruptor Information No information available
Other Adverse Effects The toxicological properties have not been fully investigated.
12. Ecological informationEcotoxicity Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Do not empty into drains. Theproduct contains following substances which are hazardous for the environment.
Component Freshwater Algae Freshwater Fish Microtox Water FleaTrifluoroacetic acid Not listed Zebrafish: LC50: >1000
mg/L/96hNot listed daphnia: EC50: 55 mg/L/24h
Persistence and Degradability Persistence is unlikely based on information available.
Bioaccumulation/ Accumulation No information available.
Mobility Will likely be mobile in the environment due to its volatility.
Component log PowTrifluoroacetic acid -2.1
13. Disposal considerationsWaste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a
hazardous waste. Chemical waste generators must also consult local, regional, andnational hazardous waste regulations to ensure complete and accurate classification.
______________________________________________________________________________________________
Page 5 / 7
14. Transport information
______________________________________________________________________________________________Trifluoroacetic acid Revision Date 18-Jan-2018
DOT UN-No UN2699Proper Shipping Name TRIFLUOROACETIC ACIDHazard Class 8Packing Group I
TDG UN-No UN2699Proper Shipping Name TRIFLUOROACETIC ACIDHazard Class 8Packing Group I
IATA UN-No UN2699Proper Shipping Name TRIFLUOROACETIC ACIDHazard Class 8Packing Group I
IMDG/IMO UN-No UN2699Proper Shipping Name TRIFLUOROACETIC ACIDHazard Class 8Packing Group I
15. Regulatory information
All of the components in the product are on the following Inventory lists:
International Inventories
Component TSCA DSL NDSL EINECS ELINCS NLP PICCS ENCS AICS IECSC KECLTrifluoroacetic acid X X - 200-929-3 - X X X X KE-3423
3X
Legend:X - ListedE - Indicates a substance that is the subject of a Section 5(e) Consent order under TSCA.F - Indicates a substance that is the subject of a Section 5(f) Rule under TSCA.N - Indicates a polymeric substance containing no free-radical initiator in its inventory name but is considered to cover the designatedpolymer made with any free-radical initiator regardless of the amount used.P - Indicates a commenced PMN substanceR - Indicates a substance that is the subject of a Section 6 risk management rule under TSCA.S - Indicates a substance that is identified in a proposed or final Significant New Use RuleT - Indicates a substance that is the subject of a Section 4 test rule under TSCA.XU - Indicates a substance exempt from reporting under the Inventory Update Rule, i.e. Partial Updating of the TSCA Inventory Data BaseProduction and Site Reports (40 CFR 710(B).Y1 - Indicates an exempt polymer that has a number-average molecular weight of 1,000 or greater.Y2 - Indicates an exempt polymer that is a polyester and is made only from reactants included in a specified list of low concern reactantsthat comprises one of the eligibility criteria for the exemption rule.
U.S. Federal Regulations
TSCA 12(b) Not applicable
SARA 313 Not applicable
SARA 311/312 Hazard Categories See section 2 for more information
CWA (Clean Water Act) Not applicable
Clean Air Act Not applicable
OSHA Occupational Safety and Health AdministrationNot applicable
______________________________________________________________________________________________
Page 6 / 7
______________________________________________________________________________________________Trifluoroacetic acid Revision Date 18-Jan-2018
CERCLA Not applicable
California Proposition 65 This product does not contain any Proposition 65 chemicals
U.S. State Right-to-KnowRegulations
Component Massachusetts New Jersey Pennsylvania Illinois Rhode Island
Trifluoroacetic acid - X - - -
U.S. Department of Transportation
Reportable Quantity (RQ): NDOT Marine Pollutant NDOT Severe Marine Pollutant N
U.S. Department of Homeland SecurityThis product does not contain any DHS chemicals.
Other International Regulations
Mexico - Grade No information available
16. Other informationPrepared By Regulatory Affairs
Thermo Fisher ScientificEmail: [email protected]
Creation Date 21-Sep-2009Revision Date 18-Jan-2018Print Date 18-Jan-2018Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard
replacing the current legislation under 29 CFR 1910.1200 to align with the GloballyHarmonized System of Classification and Labeling of Chemicals (GHS).
DisclaimerThe information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at thedate of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage,transportation, disposal and release and is not to be considered a warranty or quality specification. The informationrelates only to the specific material designated and may not be valid for such material used in combination with any othermaterials or in any process, unless specified in the text
End of SDS
______________________________________________________________________________________________
Page 7 / 7
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Revision Date 06.01.2017 Version 1.4
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 17
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 113212
Product name Acetonitrile for DNA synthesis (≤ 30 ppm H₂O)
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.
CAS-No. 75-05-8
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Reagent for analysis, Chemical production
For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * 8th Floor, Godrej One,
Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079
India * Tel: 0091 22 6210 9000
Responsible Department Quality Assurance * Merck Life Science Private Limited *
e-mail: [email protected] *
Tel : +91-2267863131-6
1.4 Emergency telephone
number
Please contact the regional company representation in your country.
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
Classification (REGULATION (EC) No 1272/2008)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 113212
Product name Acetonitrile for DNA synthesis (≤ 30 ppm H₂O)
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 17
Flammable liquid, Category 2, H225
Acute toxicity, Category 4, Oral, H302
Acute toxicity, Category 4, Inhalation, H332
Acute toxicity, Category 4, Dermal, H312
Eye irritation, Category 2, H319
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Hazard pictograms
Signal word
Danger
Hazard statements
H225 Highly flammable liquid and vapour.
H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled
H319 Causes serious eye irritation.
Precautionary statements
Prevention
P210 Keep away from heat/sparks/open flames/hot surfaces. No smoking.
P240 Ground/bond container and receiving equipment.
Response
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
Storage
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
Reduced labelling (≤125 ml)
Hazard pictograms
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 113212
Product name Acetonitrile for DNA synthesis (≤ 30 ppm H₂O)
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 17
Signal word
Danger
CAS-No. 75-05-8
2.3 Other hazards
None known.
SECTION 3. Composition/information on ingredients
3.1 Substance
Formula CH₃CN C₂H₃N (Hill)
EC-No. 200-835-2
Molar mass 41.05 g/mol
Hazardous components (REGULATION (EC) No 1272/2008)
Chemical Name (Concentration)
CAS-No. Registration number Classification
Acetonitrile (<= 100 % )
Substance does not meet the criteria for PBT or vPvB according to Regulation (EC) No 1907/2006, Annex XIII.
75-05-8 *)
Flammable liquid, Category 2, H225
Acute toxicity, Category 4, H302
Acute toxicity, Category 4, H332
Acute toxicity, Category 4, H312
Eye irritation, Category 2, H319
*) A registration number is not available for this substance as the substance or its use are exempted from registration according to Article
2 REACH Regulation (EC) No 1907/2006, the annual tonnage does not require a registration or the registration is envisaged for a later
registration deadline.
For the full text of the H-Statements mentioned in this Section, see Section 16.
3.2 Mixture
Not applicable
SECTION 4. First aid measures
4.1 Description of first aid measures
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 113212
Product name Acetonitrile for DNA synthesis (≤ 30 ppm H₂O)
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 4 of 17
After inhalation: fresh air. If breathing stops: mouth-to-mouth breathing or artificial respiration.
Oxygen if necessary. Immediately call in physician.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower. Consult a physician.
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.
After swallowing: immediately make victim drink water (two glasses at most). Consult a
physician.
4.2 Most important symptoms and effects, both acute and delayed
irritant effects, Nausea, Vomiting, Convulsions, Shortness of breath, Unconsciousness,
respiratory arrest, cardiac arrest
May cause headache and dizziness.
The following applies to cyanogen compounds/ nitriles in general: utmost caution! Release of
hydrocyanic acid is possible - blockade of cellular respiration. Cardiovascular disorders,
dyspnoea, unconsciousness.
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SECTION 5. Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Water, Carbon dioxide (CO2), Foam, Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Combustible.
Vapours are heavier than air and may spread along floors.
Forms explosive mixtures with air at ambient temperatures.
Pay attention to flashback.
Development of hazardous combustion gases or vapours possible in the event of fire.
Fire may cause evolution of:
nitrogen oxides, Hydrogen cyanide (hydrocyanic acid)
5.3 Advice for firefighters
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 113212
Product name Acetonitrile for DNA synthesis (≤ 30 ppm H₂O)
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 5 of 17
Special protective equipment for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.
Further information
Remove container from danger zone and cool with water. Suppress (knock down)
gases/vapours/mists with a water spray jet. Prevent fire extinguishing water from contaminating
surface water or the ground water system.
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapours, aerosols. Avoid substance
contact. Keep away from heat and sources of ignition. Ensure adequate ventilation. Evacuate the
danger area, observe emergency procedures, consult an expert.
Advice for emergency responders:
Protective equipment see section 8.
6.2 Environmental precautions
Do not empty into drains. Risk of explosion.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills.
Observe possible material restrictions (see sections 7 and 10).
Take up with liquid-absorbent material (e.g. Chemizorb® ). Dispose of properly. Clean up
affected area.
6.4 Reference to other sections
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handling
Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Observe label precautions.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 113212
Product name Acetonitrile for DNA synthesis (≤ 30 ppm H₂O)
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 6 of 17
Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition. Take precautionary
measures against static discharge.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and
face after working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Keep away from heat and sources of ignition. Keep container tightly closed in a dry and well-
ventilated place.
Recommended storage temperature see product label.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
Contains no substances with occupational exposure limit values.
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Eye/face protection
Safety glasses
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 113212
Product name Acetonitrile for DNA synthesis (≤ 30 ppm H₂O)
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 7 of 17
Hand protection
full contact:
Glove material: butyl-rubber
Glove thickness: 0.7 mm
Break through time: > 480 min
splash contact:
Glove material: polychloroprene
Glove thickness: 0.65 mm
Break through time: > 30 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 898 Butoject® (full contact), KCL
720 Camapren® (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Other protective equipment
Flame retardant antistatic protective clothing.
Respiratory protection
required when vapours/aerosols are generated.
Recommended Filter type: Filter A (acc. to DIN 3181) for vapours of organic compounds
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
Environmental exposure controls
Do not empty into drains.
Risk of explosion.
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 113212
Product name Acetonitrile for DNA synthesis (≤ 30 ppm H₂O)
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 8 of 17
Form liquid
Colour colourless
Odour ether-like
Odour Threshold 39.8 ppm
pH No information available.
Melting point -45.7 °C
Boiling point/boiling range 81.6 °C
at 1,013 hPa
Flash point 2 °C
Method: c.c.
Evaporation rate No information available.
Flammability (solid, gas) No information available.
Lower explosion limit 3.0 %(V)
Upper explosion limit 17 %(V)
Vapour pressure 97 hPa
at 20 °C
Relative vapour density 1.42
Density 0.786 g/cm3
at 20 °C
Relative density No information available.
Water solubility at 20 °C
soluble
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 113212
Product name Acetonitrile for DNA synthesis (≤ 30 ppm H₂O)
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 9 of 17
Partition coefficient: n-
octanol/water
log Pow: -0.34
(IUCLID) Bioaccumulation is not expected.
Auto-ignition temperature No information available.
Decomposition temperature Distillable in an undecomposed state at normal pressure.
Viscosity, dynamic 0.316 mPa.s
at 25 °C
Explosive properties Not classified as explosive.
Oxidizing properties none
9.2 Other data
Ignition temperature 524 °C
SECTION 10. Stability and reactivity
10.1 Reactivity
Vapours may form explosive mixture with air.
10.2 Chemical stability
heat-sensitive
Distillable in an undecomposed state at normal pressure.
10.3 Possibility of hazardous reactions
Violent reactions possible with:
Strong bases, strong reducing agents
Risk of explosion with:
nitrates, perchlorates, perchloric acid
conc. sulfuric acid, with, Heat
Risk of ignition or formation of inflammable gases or vapours with:
Oxidizing agents, Nitric acid
nitrogen dioxide, with, Catalyst
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 113212
Product name Acetonitrile for DNA synthesis (≤ 30 ppm H₂O)
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 10 of 17
Generates dangerous gases or fumes in contact with:
Acids
10.4 Conditions to avoid
Warming.
10.5 Incompatible materials
rubber, various plastics
10.6 Hazardous decomposition products
in the event of fire: See section 5.
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Acute oral toxicity
LD50 Mouse: 617 mg/kg
OECD Test Guideline 401
Symptoms: Nausea, Vomiting
Acute inhalation toxicity
Symptoms: Possible damages:, mucosal irritations
Acute dermal toxicity
This information is not available.
Skin irritation
Rabbit
Result: No skin irritation
OECD Test Guideline 404
Eye irritation
Rabbit
Result: Eye irritation
OECD Test Guideline 405
Causes serious eye irritation.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 113212
Product name Acetonitrile for DNA synthesis (≤ 30 ppm H₂O)
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 11 of 17
Sensitisation
Buehler Test Guinea pig
Result: negative
Method: OECD Test Guideline 406
Germ cell mutagenicity
Genotoxicity in vivo
In vivo micronucleus test
Mouse
male and female
i.p.
Result: negative
Method: OECD Test Guideline 474
Genotoxicity in vitro
Ames test
Salmonella typhimurium
Result: negative
(External MSDS)
Mutagenicity (mammal cell test):
Mouse lymphoma test
Result: negative
Method: OECD Test Guideline 476
Carcinogenicity
This information is not available.
Reproductive toxicity
This information is not available.
Teratogenicity
This information is not available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 113212
Product name Acetonitrile for DNA synthesis (≤ 30 ppm H₂O)
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 12 of 17
CMR effects
Carcinogenicity:
Based on available data the classification criteria are not met.
Mutagenicity:
Based on available data the classification criteria are not met.
Teratogenicity:
Based on available data the classification criteria are not met.
Reproductive toxicity:
Based on available data the classification criteria are not met.
Specific target organ toxicity - single exposure
The substance or mixture is not classified as specific target organ toxicant, single exposure.
Specific target organ toxicity - repeated exposure
The substance or mixture is not classified as specific target organ toxicant, repeated exposure.
Aspiration hazard
This information is not available.
11.2 Further information
After absorption:
Systemic effects:
Shortness of breath, Headache, Dizziness, Nausea, Convulsions, Unconsciousness, respiratory
arrest, cardiac arrest
Symptoms may be delayed.
The following applies to cyanogen compounds/ nitriles in general: utmost caution! Release of
hydrocyanic acid is possible - blockade of cellular respiration. Cardiovascular disorders,
dyspnoea, unconsciousness.
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
SECTION 12. Ecological information
12.1 Toxicity
Toxicity to fish
semi-static test LC50 Oryzias latipes (Orange-red killifish): > 100 mg/l; 96 h
OECD Test Guideline 203
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 113212
Product name Acetonitrile for DNA synthesis (≤ 30 ppm H₂O)
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 13 of 17
Toxicity to daphnia and other aquatic invertebrates
semi-static test EC50 Daphnia magna (Water flea): > 1,000 mg/l; 48 h
OECD Test Guideline 202
semi-static test NOEC Daphnia magna (Water flea): 960 mg/l; 21 d
OECD Test Guideline 202
Toxicity to algae
static test EC50 Pseudokirchneriella subcapitata (green algae): > 1,000 mg/l; 72 h
OECD Test Guideline 201
static test NOEC Pseudokirchneriella subcapitata (green algae): > 1,000 mg/l; 72 h
OECD Test Guideline 201
IC5 Scenedesmus quadricauda (Green algae): 7,300 mg/l; 8 d
(IUCLID) (maximum permissible toxic concentration)
Toxicity to bacteria
EC5 Pseudomonas putida: 680 mg/l; 16 h
(IUCLID) (maximum permissible toxic concentration)
12.2 Persistence and degradability
Biodegradability
70 %; 21 d
OECD Test Guideline 310
Readily biodegradable
12.3 Bioaccumulative potential
Partition coefficient: n-octanol/water
log Pow: -0.34
(IUCLID) Bioaccumulation is not expected.
Bioaccumulation
Bioconcentration factor (BCF): 0.3
Lepomis macrochirus (Bluegill sunfish)
Does not significantly accumulate in organisms.
Information taken from reference works and the literature.
12.4 Mobility in soil
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 113212
Product name Acetonitrile for DNA synthesis (≤ 30 ppm H₂O)
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 14 of 17
Distribution among environmental compartments
Adsorption/Soil
log Koc: 1.21
Mobile in soils (Lit.)
12.5 Results of PBT and vPvB assessment
Substance does not meet the criteria for PBT or vPvB according to Regulation (EC) No
1907/2006, Annex XIII.
12.6 Other adverse effects
Stability in water
DT50
> 9,999 d
at pH: 7
(calculated) Hydrolyses slowly.
Additional ecological information
Biological effects:
Hazard for drinking water supplies.
Discharge into the environment must be avoided.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 113212
Product name Acetonitrile for DNA synthesis (≤ 30 ppm H₂O)
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 15 of 17
SECTION 13. Disposal considerations
Waste treatment methods
Waste material must be disposed of in accordance with the national and local regulations. Leave
chemicals in original containers. No mixing with other waste. Handle uncleaned containers like
the product itself.
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 UN number UN 1648
14.2 Proper shipping name ACETONITRILE
14.3 Class 3
14.4 Packing group II
14.5 Environmentally hazardous --
14.6 Special precautions for
user
yes
Tunnel restriction code D/E
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)
14.1 UN number UN 1648
14.2 Proper shipping name ACETONITRILE
14.3 Class 3
14.4 Packing group II
14.5 Environmentally hazardous --
14.6 Special precautions for
user
no
Sea transport (IMDG)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 113212
Product name Acetonitrile for DNA synthesis (≤ 30 ppm H₂O)
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 16 of 17
14.1 UN number UN 1648
14.2 Proper shipping name ACETONITRILE
14.3 Class 3
14.4 Packing group II
14.5 Environmentally hazardous --
14.6 Special precautions for
user
yes
EmS F-E S-D
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National legislation
Storage class 3
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Full text of H-Statements referred to under sections 2 and 3.
H225 Highly flammable liquid and vapour.
H302 Harmful if swallowed.
H312 Harmful in contact with skin.
H319 Causes serious eye irritation.
H332 Harmful if inhaled.
Training advice
Provide adequate information, instruction and training for operators.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 113212
Product name Acetonitrile for DNA synthesis (≤ 30 ppm H₂O)
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 17 of 17
Labelling
Hazard pictograms
Signal word
Danger
Hazard statements
H225 Highly flammable liquid and vapour.
H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled
H319 Causes serious eye irritation.
Precautionary statements
Prevention
P210 Keep away from heat/sparks/open flames/hot surfaces. No smoking.
P240 Ground/bond container and receiving equipment.
Response
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
Storage
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
Safety Data Sheet
Issue Date: October 2013 Page 1 of 8Product: Labtech Absolute Alcohol
Absolute Alcohol
Section 1: Identification of the material and supplier
Product name: Absolute Alcohol (Ethanol)Other names: Ethyl Alcohol, Undenatured Ethanol, Absolute Alcohol, EthanolProduct Codes/Trade Names: EL, EL95, EL100, AA100HG
Recommended use: Histology, Cytology, General laboratory solvent, ReagentApplicable in: AustraliaSupplier: Labtech Service & SuppliesAddress: PO Box 453, Windsor NSW 2756Telephone: 02 8064 2333Email address: [email protected] site: www.labtech.com.auFacsimile: 02 8064 7813Emergency phone number: 000 Fire Brigade and Police (available in Australia only)
1800 774 557 Transpacific Emergency Response (available in Australiaonly)
Poisons Information Centre: 13 11 26 (available in Australia only)
This Safety Data Sheet (SDS) is issued by the Supplier in accordance with National Standards and Guidelines from SafeWork Australia (SWA – formerly ASCC/NOHSC). The information in it must not be altered, deleted or added to. The Supplierwill not accept any responsibility for any changes made to its SDS by any other person or organization. The Supplier willissue a new SDS when there is a change in product specifications and/or Standards, Codes, Guidelines, or Regulations.
Section 2: Hazard identification
Statement of hazardous nature: Classified as Hazardous according to the Approved Criteria For ClassifyingHazardous Substances [NOHSC:1008] 3rd Edition.Ethanol is classified as Dangerous Goods according to the Australian Code for the Transport of DangerousGoods by Road and Rail.
Risk Phrases Safety PhrasesR11 - Highly flammable.R20/22 - Harmful by inhalation and if swallowed.R36/38 - Irritating to eyes and skin.R66 - Repeated exposure may cause skin drynessand cracking.
S7/9 - Keep container tightly closed and in a wellventilated place.S16 - Keep away from sources of ignition - Nosmoking.S23 - Do not breathe vapour.S24/25 - Avoid contact with skin and eyes.S29 - Do not empty into drains.S33 - Take precautionary measures against staticdischarges.S36/37/39 - Wear suitable protective clothing/glovesand eye/face protection.S45 - In case of accident or if you feel unwell seekmedical advice immediately (show the labelwhenever possible).
Safety Data Sheet
Issue Date: October 2013 Page 2 of 8Product: Labtech Absolute Alcohol
Section 3: Composition / Information on ingredients
Chemical Name: Synonyms Proportion: CAS Number:
Ethyl AlcoholWater
Ethanol_
70 - 100%0 - 35% by wt
64-17-57732-18-5
Section 4: First aid measures
If there are signs of drunkenness (intoxication or inebriation) then serious health effects may follow(depending on the amount swallowed or inhaled).Immediate medical attention should be sought and the affected person transferred and accompanied to thecare of a doctor or hospital. Treat unconsciousness by placing the person in the coma position. Applyartificial respiration if breathing stops.
Swallowed: See above. If a minor amount has been accidentally swallowed, then, if conscious,dilute stomach contents by giving large amounts of water. Do not allow further workuntil fitness for duties is established.Do not attempt to induce vomiting or give anything by mouth to an unconscious person.Seek medical attention.
Eyes: Flush eye with water for a minimum of 15 minutes. Seek medical attention promptly ifirritation persists or any loss of vision occurs.
Skin: Immediately remove contaminated clothing. Wash skin with water. Laundercontaminated clothing before re-use.
Inhaled: Remove promptly to fresh air. If there are signs of drunkenness (intoxication orinebriation) or respiratory irritation, dizziness, nausea or headache occurs, seekimmediate medical attention.Treat unconsciousness by placing the person in the coma position. Apply artificialrespiration if breathing stops.
First Aid Facilities: Safety showers, eye wash stations and First Aid kits.
Advice to Doctor: Treat symptomatically and as for a narcotic substance.
Section 5: Fire fighting measures
Flammability: Highly flammable liquid. May form flammable mixtures with air. Burnswith a colourless flame. The vapour is heavier than air and may travelalong the ground; distant ignition and flash back are possible.Run off to sewers and drains may cause explosions. Isolate for at least800 metres in all directions if tanks or tankers are involved. The use ofcompressed air for filling, discharging, mixing or handling is prohibiteddue to the vapour hazard.All vessels must be earthed to avoid generation of static charges whenagitating or transferring solvents. Avoid all ignition sources. Intrinsicallysafe equipment is necessary in areas where this chemical is being used.
Suitable extinguishing media: Alcohol resistant foam is the preferred fire fighting medium but, if it is notavailable, fine water spray can be used. Water fog, fine water spray, drychemical or carbon dioxide may also be used.
Hazards from combustionproducts:
Burning can produce carbon monoxide and/or carbon dioxide.
Special protective precautionsand equipment for fire fighters:
Highly flammable liquid. Contain spill. Full fire kit and breathingapparatus is required.
Safety Data Sheet
Issue Date: October 2013 Page 3 of 8Product: Labtech Absolute Alcohol
Use water to cool exposed containers. Heating can cause expansion ordecomposition leading to violent rupture of containers. If safe to do so,remove containers from path of fire.Spills and leaks may be washed away with copious volumes of water,fog or spray. Prevent run-off from entering drains and watercourses.
HAZCHEM Code: ●2YE
Section 6: Accidental release measures
Emergency Procedure: In the event of a spill eliminate all sources of ignition and take measuresto prevent static discharge. No smoking. Use water spray to dispersevapour.Clear area of all personnel not directly involved in the clean up.All personnel involved in the containment and disposal procedures towear protective equipment as described in Section 8 to prevent skin andeye contamination and inhalation of vapours.Ventilate area well and ensure the atmosphere is safe before personnelreturn to the work area.
Containment Procedure: Stop and contain the spill for salvage or absorb in inert absorbentmaterial (e.g. soil, sand, vermiculite) for disposal by an approvedmethod. Prevent run-off into drains and waterways.If contamination of sewers or waterways has occurred, advise the localemergency services.
Clean Up Procedure: Wash the cleaned-up area with copious volumes of water to remove anytrace amounts of product. Spills can be converted to non-flammablemixtures by dilution with water.Non-returnable containers should be de-gassed prior to disposal.Dispose of all waste containers and used drums in accordance with localauthority guidelines.
Section 7: Handling and storage
Handling: Use in well ventilated areas away from all ignition sources. Intrinsicallysafe equipment only must be used in areas where this chemical is beingused.The use of compressed air for filling, discharging, mixing or handling isprohibited due to the vapour hazard. Containers must be earthed toavoid generation of static charges when agitating or transferring product.
Storage: Store in tightly closed containers in cool, dry, isolated and well-ventilatedareas away from heat, sources of ignition and incompatibles (see below).Store away from oxidizing agents. Keep containers closed at all times -check regularly for leaks.Do not eat, drink or smoke in areas of use or storage. Observe StateRegulations concerning the storage and handling of Dangerous Goods.Store with all precautions required for handling flammable liquids.The requirement of Australian Standard AS 1940 should be observed inaddition to AS 1020, AS 1076, AS 2380 and AS 3000.Empty containers retain residue (liquid and/or vapour) and aredangerous. Do not pressure cut, weld, braze, solder, drill, grind orexpose such containers to heat, flame, sparks, static electricity, or othersources of ignition.
Safety Data Sheet
Issue Date: October 2013 Page 4 of 8Product: Labtech Absolute Alcohol
Incompatibilities: Not to be stored with explosives (Class 1), flammable gases in bulk(Class 2.1), poisonous gases (Class 2.3), spontaneously combustiblesubstances (Class 4.2), oxidizing agents (Class 5.1), organic peroxides(Class 5.2), radioactive substances (Class 7).Exemptions may apply.
Section 8: Exposure controls / Personal protection
Exposure Standards: National Occupational Exposure Standard (NES), Safe WorkAustralia (formerly ASCC/NOHSC).
Ethanol:TWA - 1000 ppm (1880 mg/m3)
Notes: All occupational exposures to atmospheric contaminants should be keptto as low a level as is workable (practicable) and in all cases to below theNational Standard.These exposure standards are guides to be used in the control ofoccupational health hazards. These exposure standards should not beused as fine dividing lines between safe and dangerous concentrationsof chemicals. They are not a measure of relative toxicity.TWA (Time Weighted Average): the time-weighted average airborneconcentration over an eight-hour working day, for a five-day workingweek over an entire working life. According to current knowledge thisconcentration should neither impair the health of, nor cause unduediscomfort to, nearly all workers.
Biological Limit Values: No biological limit allocated.
ENGINEERING CONTROLS
Ventilation: Local exhaust ventilation and/or mechanical (general) exhaust isrecommended where vapours are likely to be generated. All suchequipment must be intrinsically safe.
Special Consideration forRepair &/or Maintenance ofContaminated Equipment:
Empty containers retain residue (liquid and/or vapour) and aredangerous. Do not pressure cut, weld, braze, solder, drill, grind orexpose such containers to heat, flame, sparks, static electricity, or othersources of ignition.Vapour is heavier than air - prevent concentration in hollows or sumps.Do not enter confined spaces where vapour may have collected. Keepcontainers closed when not in use.
PERSONAL PROTECTION
Personal Hygiene Protective clothing (gloves, coveralls, boots, etc.) should be worn toprevent skin contact. Always wash hands before smoking, eating,drinking or using the toilet.Wash contaminated clothing and other protective equipment beforestoring or re-using.
Skin Protection: Avoid skin contact by the use of approved chemical resistant gloves andaprons - PVC or Neoprene (AS 2161).
Eye Protection: Avoid eye contact by wearing chemical goggles with side-shields or face-shield (AS/NZS 1336) whenever exposed to vapour or mist or if there isa risk of splashing liquid in the eyes.Safety showers with eye-wash should be provided in all areas whereproduct is handled.
Safety Data Sheet
Issue Date: October 2013 Page 5 of 8Product: Labtech Absolute Alcohol
Respiratory Protection: None should be needed if engineering, storage and handling controls areadequate to ensure that atmospheric contamination is kept below theNational Standard.Where vapour concentrations are likely to approach or exceed theNational Standard, an approved organic vapour respirator (AS/NZS 1715and 1716) must be worn.In high vapour concentrations, or in suspected oxygen-deficientatmospheres such as empty vessels or confined spaces, use air-supplied hood.
Thermal Protection: None should be needed under normal circumstances.
Smoking & Other Dusts Smoking must be prohibited in all areas where this product is used. Seesafety information on flammability above.
Section 9: Physical and chemical properties
Appearance: Clear colourless liquid
Odour: Ethanol odour detectable at 80 - 100 ppm.
pH, at stated concentration: Not available
Vapour Pressure: 44 mm Hg @ 20°C
Vapour Density: 1.59 (air = 1)
Boiling Point/range (°C): 78°C (Ethanol)
Freezing/Melting Point (°C): -117°C
Solubility: Complete
Specific Gravity (H2O = 1): Approximately 0.8
FLAMMABLE MATERIALS
Flash Point: 13°C (Ethanol)
Flash Point Method: Abel closed cup
Flammable (Explosive)Limit - Upper:
19%
Flammable (Explosive)Limit - Lower:
3.5%
Autoignition Temperature: 392°C
ADDITIONAL PROPERTIES
Evaporation Rate: 253 (n-Butyl Acetate = 100)
Molecular Weight: Not available
Volatile OrganicCompounds Content(VOC):(as specified by the GreenBuilding Council of Australia)
100%
% Volatiles: 100%
Safety Data Sheet
Issue Date: October 2013 Page 6 of 8Product: Labtech Absolute Alcohol
Swallowed: Accidental swallowing is unlikely in the industrial setting. Swallowing ethanol cancause drunkenness or harmful central nervous system effects. The deliberateingestion of ethanol is a known occupational risk.As little as 50 - 100 ml intake in a shift in a 70kg worker may cause inebriation to thepoint where safety is impaired. Effects of a small intake may include excitation,euphoria, headache, dizziness, drowsiness, blurred vision, and fatigue.Drinking a large amount may lead to severe acute intoxication, tremors, convulsions,loss of consciousness, coma, respiratory arrest and death. Aspiration into lungs maycause pneumonitis.
Eyes: Vapours may irritate the eyes. Liquid and mists may severely irritate or damage theeyes.
Skin: Contact with skin may result in slight irritation and redness.
Inhaled: Vapour is moderately irritating to mucous membranes and respiratory tract. Inhalationof the vapour may result in drunkenness (see effects of swallowing above) orheadache, nausea, incoordination, narcosis (sleepiness) and vomiting.Early signs or symptoms may occur at airborne levels of 1000 to 5000 ppm.
Section 10: Stability and reactivity
Chemical Stability: Stable
Incompatible Materials: Will react with strong oxidizing agents.
Conditions to avoid: Heat, sparks, flame and build-up of static electricity.
Hazardous DecompositionProducts:
Burning can produce carbon monoxide and/or carbon dioxide.
Hazardous Reactions: Hazardous polymerisation will not occur.
Section 11: Toxicological information
Toxicological Data:LD50/oral/rat: 7060 mg/kg (literature data)LC50/inhalation/rat: 38 mg/l/10 h (literature data)
Health effects information is based on reported effects in use from overseas and Australian reports.
Effects: Acute
Effects: ChronicLong term exposure by swallowing or repeated inhalation may cause degenerative changes in the liver,kidneys, gastrointestinal tract and heart muscle.Prolonged or repeated contact and heavy skin contamination may cause skin drying and cracking and/ordermatitis with redness, itching, and swelling. This may lead to secondary infection.Ongoing or repeated exposures at high concentrations may cause central nervous system symptoms similarto "Acute: Swallowed" above. Deliberate inhalation of the vapour is a known occupational risk.
Safety Data Sheet
Issue Date: October 2013 Page 7 of 8Product: Labtech Absolute Alcohol
Additional NotesNasal and eye irritation may occur at concentrations below the exposure standard. Exposure to ethanol in thework setting adds to any intake from alcoholic drinks and any health effects caused by the total intake ofalcohol.In work areas where exposures in excess of the occupational exposure limits occur, then the following mayapply:- Persons with pre-existing liver impairment, skin and respiratory disorders may be at an increased risk.- Ethanol may cause adverse reproductive effects.- Absorption of some drugs may be affected causing adverse health effects.- Ingestion by pregnant women may cause serious effects in their newborn babies called "foetal alcoholsyndrome".The National Occupational Health & Safety Commission in Australia (NOHSC) does not classify ethanol as acarcinogen.IARC has evaluated ethanol as a carcinogen on the basis of effects of drinking alcoholic beverages, but thereis no known carcinogenic risk from occupational exposures.There is extensive toxicological and epidemiological information on the health effects of ingesting alcoholicdrinks containing ethanol.Inhalation at levels at or exceeding the Occupational Exposure limits or any deliberate ingestion is known tolead to health effects which may be evident in themselves or lead to impaired functioning and consequentsafety risks in the industrial setting.A blood alcohol level in excess of 0.05g/100ml is regarded as likely to impair functioning for tasks such asoperating machinery.
Section 12: Ecological information
Eco-toxicity: Toxicity to fish (acute): LC50/Golden ide/: >1000 mg/l/48 hToxicity to daphnia: EC50/Daphnia magna/: >1000 mg/l/24 h
Persistence andDegradability:
Degree of elimination: 94%Evaluation: biodegradable
Mobility: No data available
Section 13: Disposal considerations
Suitable for incineration by approved agent under controlled conditions if permitted by local authorities,otherwise disposal must be in accordance with local waste authority requirements.Product must be contained and not disposed to sewerage systems, drains or waterways. Advise flammablenature. Empty containers must be decontaminated by rinsing with water.
Section 14: Transport information
Proper Shipping Name: ETHANOLUN number: 1170DG Class: 3Subsidiary Risk 1: None AllocatedPackaging Group: IIHAZCHEM code: ●2YEMarine Pollutant: NoSpecial Precautions forUser:
Refer to incompatibilities in Section 7 and stability and reactivity information inSection 10.
ADDITIONAL TRANSPORT REQUIREMENTS: Nil
Safety Data Sheet
Issue Date: October 2013 Page 8 of 8Product: Labtech Absolute Alcohol
Section 15: Regulatory information
Poisons Schedule: Not Scheduled
Other: Nil
Section 16: Other information
Additional Information
Australian Standards References:AS 1020 The Control of Undesirable Static Electricity.AS 1076 Code of Practice for selection, installation and maintenance of electrical
apparatus and associated equipment for use in explosive atmospheres (otherthan mining applications) – Parts 1 to 13
AS/NZS 1336 Recommended Practices for Occupational Eye ProtectionAS/NZS 1715 Selection, Use and Maintenance of Respiratory Protective DevicesAS/NZS 1716 Respiratory Protective DevicesAS 1940 The Storage and Handling of Flammable and Combustible LiquidsAS 2161 Industrial Safety Gloves and Mittens (excluding electrical and medical gloves)AS 2380 Electrical equipment for explosive atmospheres – Explosion Protection
Techniques (Parts 1 to 9)AS 3000 Electrical installations (known as the Australian/New Zealand Wiring Rules).
Other References:NOHSC:2011 (2003) National Code of Practice for the Preparation of Material Safety Data Sheets 2nd
Edition, April 2003, National Occupational Health and Safety Commission.NOHSC; 2012 (1994) National Code of Practice for the Labelling of Workplace Substances, March 1994,
Australian Government Publishing Service, Canberra.NES National Occupational Exposure Standards for Workplace Atmospheric
Contaminants (NES), Safe Work Australia (formerly ASCC/NOHSC) 1995 asamended.
ADG Code Australian Dangerous Goods Code 7th Edition.
Authorisation
Authorised by: Quality & Technical ManagerDate of Issue: October 2013Review/Expiry Date: Sept 2018
Whilst the information contained in this document is based on data which, to the best of our knowledge, was accurate and reliable at the timeof preparation, no responsibility can be accepted by us for errors and omissions. The provision of this information should not be construed asa recommendation to use any of our products in violation of any patent rights or in breach of any statute or regulation. Users are advised tomake their own determination as to the suitability of this information in relation to their particular purposes and specific circumstances. Sincethe information contained in this document may be applied under conditions beyond our control, no responsibility can be accepted by us forany loss or damage caused by any person acting or refraining from action as a result of this information.
END OF SDS
SAFETY DATA SHEET
Document Type EGHS - EuropeGHS
Revision date 27-Jun-2016 Version 3
Section 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THECOMPANY/UNDERTAKING
1.1. Product identifier
Product name Enterokinase, light chainProduct No P8070
1.2. Relevant identified uses of the substance or mixture and uses advised against Recommended use This product is for research and development onlyUses advised against No information available
1.3. Details of the supplier of the safety data sheet Supplier Address New England BioLabs
240 County RoadIpswich, MA 01938USA
Company Phone Number 978-927-5054800-632-5227 (toll free)
Telefax 978-921-1350For further information, please contact
E-mail address [email protected]. Emergency telephone number
Emergency telephone 978-927-5054800-632-5227 (toll free)9:00am - 5:00pm Monday-Friday EST
Emergency telephone - §45 - (EC)1272/2008Europe 112
_____________________________________________________________________________________________
Specification No No information available
Product name Enterokinase, lightchain
Page 1 / 9 Product No P8070
_____________________________________________________________________________________________
Section 4: FIRST AID MEASURES
4.1. Description of first aid measures
General adviceImmediate medical attention is required. In case of accident or unwellness, seek medical advice immediately (show directions foruse or safety data sheet if possible). Remove from exposure, lie down. Do not breathe dust/fume/gas/mist/vapors/spray.
Eye contactRinse thoroughly with plenty of water for at least 15 minutes, lifting lower and upper eyelids. Consult a physician.
Skin contactWash skin with soap and water.
InhalationRemove to fresh air.
IngestionClean mouth with water and drink afterwards plenty of water.
4.2. Most important symptoms and effects, both acute and delayed No information available
4.3. Indication of any immediate medical attention and special treatment needed
Note to physiciansTreat symptomatically.
Section 2: HAZARDS IDENTIFICATION
2.1. Classification of the substance or mixture Regulation (EC) No 1272/2008This mixture is classified as not hazardous according to regulation (EC) 1272/2008 [GHS]
2.2. Label elements Product identifierThis mixture is classified as not hazardous according to regulation (EC) 1272/2008 [GHS]Signal wordNone
EUH210 - Safety data sheet available on request
2.3. Other hazards
Section 3: COMPOSITION/INFORMATION ON INGREDIENTS
3.1 Substances
Not applicable
3.2 Mixtures
Full text of H- and EUH-phrases: see section 16
_____________________________________________________________________________________________
Specification No No information available
Product name Enterokinase, lightchain
Page 2 / 9 Product No P8070
_____________________________________________________________________________________________
Section 5: FIRE FIGHTING MEASURES
5.1. Extinguishing media Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.
Unsuitable extinguishing mediaCAUTION: Use of water spray when fighting fire may be inefficient.
5.2. Special hazards arising from the substance or mixture No information available
5.3. Advice for firefighters As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and fullprotective gear.
Section 6: ACCIDENTAL RELEASE MEASURES
6.1. Personal precautions, protective equipment and emergency procedures
Personal precautionsEnsure adequate ventilation, especially in confined areas.
For emergency respondersUse personal protection recommended in Section 8.
6.2. Environmental precautions See Section 12 for additional Ecological Information.
6.3. Methods and material for containment and cleaning up
Methods for containmentPrevent further leakage or spillage if safe to do so.
Methods for cleaning upSoak up with inert absorbent material. Pick up and transfer to properly labeled containers. This material and its container must bedisposed of as hazardous waste.
Section 7: HANDLING AND STORAGE
7.1. Precautions for safe handling Handle in accordance with good industrial hygiene and safety practice.
7.2. Conditions for safe storage, including any incompatibilities
Storage temperatureRefer to www.neb.com for specific information.
Storage ConditionsKeep/store only in original container.
Incompatible materialsNone known based on information supplied.
7.3. Specific end use(s)
Risk management methods [RMM]The information required is contained in this Safety Data Sheet.
_____________________________________________________________________________________________
Specification No No information available
Product name Enterokinase, lightchain
Page 3 / 9 Product No P8070
_____________________________________________________________________________________________
Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1. Control parameters
Exposure Limits This product, as supplied, does not contain any hazardous materials with occupationalexposure limits established by the region specific regulatory bodies
Derived No Effect Level (DNEL) No information available
Predicted No Effect Concentration(PNEC)
No information available
8.2. Exposure controls
Engineering controlsShowers. Eyewash stations.
Individual protection measures, such as personal protective equipmentEye/face protectionWear safety glasses with side shields (or goggles).
Skin and body protectionWear suitable protective clothing and gloves.
Respiratory protectionUse in well ventilated areas.
General hygiene considerationsHandle in accordance with good industrial hygiene and safety practice.
Environmental exposure controlsSee Section 12: ECOLOGICAL INFORMATION.
Section 9: PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
Physical state LiquidAppearance ColorlessOdor MildOdor threshold No information available
Property Remarks • Method pH Refer to www.neb.com for specific informationMelting point / freezing point No information availableBoiling point / boiling range No information availableFlash point No information availableEvaporation rate No information availableFlammability (solid, gas) No information availableFlammability Limit in Air No information available
Upper flammability limitLower flammability limit
Vapor pressure No information availableVapor density No information availableRelative density No information availableSpecific gravity No information availableWater solubility No information availableSolubility in other solvents No information availablePartition coefficient No information availableAutoignition temperature No information available
_____________________________________________________________________________________________
Specification No No information available
Product name Enterokinase, lightchain
Page 4 / 9 Product No P8070
_____________________________________________________________________________________________
Other information
Section 10: STABILITY AND REACTIVITY
10.1. Reactivity
10.2. Chemical stability Stable under normal conditions.
10.3. Possibility of hazardous reactions Can react briskly with oxidizers - danger of explosion.
10.4. Conditions to avoid Incompatible materials. Ignition sources. Heat.
10.5. Incompatible materials Strong oxidizing agents.
10.6. Hazardous decomposition products Thermal decomposition can lead to release of irritating and toxic gases and vapors. Carbon monoxide. Carbon dioxide (CO2).
Section 11: TOXICOLOGICAL INFORMATION
11.1. Information on toxicological effects
Acute toxicity
Product informationProduct does not present an acute toxicity hazard based on known or supplied information.
InhalationAvoid breathing vapors or mistsMay cause irritation of respiratory tract
Eye contactRednessMay cause slight irritation
Skin contactProlonged contact may cause redness and irritationRepeated exposure may cause skin dryness or cracking
IngestionMay cause drowsiness or dizzinessIngestion may cause gastrointestinal irritation, nausea, vomiting and diarrheaSymptoms include burning sensation, coughing, wheezing, shortness of breath, headache, nausea, and vomiting
Unknown acute toxicity 51.5 % of the mixture consists of ingredient(s) of unknown toxicity
Decomposition temperature No information availableKinematic viscosity No information availableDynamic viscosity No information availableExplosive properties No information availableOxidizing properties No information available
Softening point No information availableMolecular weight No information availableVOC content (%) No information availableDensity No information availableBulk density No information available
No data available.
_____________________________________________________________________________________________
Specification No No information available
Product name Enterokinase, lightchain
Page 5 / 9 Product No P8070
_____________________________________________________________________________________________
The following values are calculated based on chapter 3.1 of the GHS documentATEmix (oral) 22,892.00 mg/kgATEmix (dermal) 19,531.00 mg/kgATEmix (inhalation-vapor) 860.00 mg/l
Skin corrosion/irritation MildSerious eye damage/eye irritation MildSensitization Not applicableGerm cell mutagenicity Not applicable
Carcinogenicity No information available
Reproductive toxicity No information availableDevelopmental toxicity No information availableTeratogenicity No information availableSTOT - single exposure No information availableSTOT - repeated exposure No information availableNeurological effects No information availableTarget organ effects Eyes, Kidneys, Respiratory system, Skin.Other adverse effects No information availableSymptoms No information availableAspiration hazard No information available
Section 12: ECOLOGICAL INFORMATION
12.1. Toxicity
0.3 % of the mixture consists of component(s) of unknown hazards to the aquatic environment
12.2. Persistence and degradability No information available
12.3. Bioaccumulative potential No information available
12.4. Mobility in soil No information available
12.5. Results of PBT and vPvB assessment No information available
12.6. Other adverse effects
Other adverse effectsNo information available
Endocrine disruptor informationNo information available
OzoneNo information available
_____________________________________________________________________________________________
Specification No No information available
Product name Enterokinase, lightchain
Page 6 / 9 Product No P8070
_____________________________________________________________________________________________
Section 13: DISPOSAL CONSIDERATIONS
13.1. Waste treatment methods
Relevant InformationKeep out of drains, sewers, ditches and waterways.
Waste from Residues/Unused ProductsDisposal should be in accordance with applicable regional, national and local laws and regulations. Send to a licensed recycler,reclaimer or incinerator.
Contaminated packagingEmpty containers must be tripled rinsed prior to disposal.
Section 14: TRANSPORT INFORMATION
IMDG 14.1 UN/ID No Not regulated14.2 Proper shipping name Not regulated14.3 Hazard class Not regulated14.4 Packing group Not regulated14.5 Marine pollutant Not applicable14.6 Special Provisions None14.7 Transport in bulk according toAnnex II of MARPOL 73/78 and theIBC Code
No information available
RID 14.1 UN/ID No Not regulated14.2 Proper shipping name Not regulated14.3 Hazard class Not regulated14.4 Packing group Not regulated14.5 Environmental hazard Not applicable14.6 Special Provisions None
ADR 14.1 UN/ID No Not regulated14.2 Proper shipping name Not regulated14.3 Hazard class Not regulated14.4 Packing group Not regulated14.5 Environmental hazard Not applicable14.6 Special Provisions None
ICAO (air) 14.1 UN/ID No Not regulated14.2 Proper shipping name Not regulated14.3 Hazard class Not regulated14.4 Packing group Not regulated14.5 Environmental hazard Not applicable14.6 Special Provisions None
IATA 14.1 UN/ID No Not regulated14.2 Proper shipping name Not regulated14.3 Hazard class Not regulated14.4 Packing group Not regulated14.5 Environmental hazard Not applicable14.6 Special Provisions None
_____________________________________________________________________________________________
Specification No No information available
Product name Enterokinase, lightchain
Page 7 / 9 Product No P8070
_____________________________________________________________________________________________
Section 15: REGULATORY INFORMATION
15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture
National Regulations
Occupational Illnesses (R-463-3, France)
European Union
Take note of Directive 98/24/EC on the protection of the health and safety of workers from the risks related to chemical agents atwork
International Inventories All of the components in the product are on the following Inventory lists TSCA (United States):, Canada (DSL/NDSL),Europe (EINECS/ELINCS), Australia (AICS), South Korea (KECL):, China (IECSC), Philippines (PICCS).
TSCA CompliesEINECS CompliesELINCS -DSL CompliesNDSL CompliesPICCS CompliesENCS -IECSC CompliesAICS CompliesKECL Complies
Legend TSCA - United States Toxic Substances Control Act Section 8(b) Inventory EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List PICCS - Philippines Inventory of Chemicals and Chemical Substances ENCS - Japan Existing and New Chemical Substances IECSC - China Inventory of Existing Chemical Substances AICS - Australian Inventory of Chemical Substances KECL - Korean Existing and Evaluated Chemical Substances
15.2. Chemical safety assessment No information available
Section 16: OTHER INFORMATION
Key or legend to abbreviations and acronyms used in the safety data sheet
Prepared by EH&S Manager978-927-5054
Prepared by New England BioLabsIssue date No data availableRevision note SDS is valid 3 years from revision date. Contact [email protected] for latest revision.
This safety data sheet complies with the requirements of: Regulation (EC) No. 1907/2006
DisclaimerIMPORTANT: The information in this SDS is provided in good faith based on our knowledge as of the issue date (orsubsequent revision date, if any), and is to be used only as a guide. This SDS does not constitute a guarantee (expressor implied) of any kind and we make no warranties or merchantability or fitness for a particular purpose. This informationrelates only to the designated product as shipped and may not be valid if the product is used in combination with any
_____________________________________________________________________________________________
Specification No No information available
Product name Enterokinase, lightchain
Page 8 / 9 Product No P8070
_____________________________________________________________________________________________
other materials or is not used in accordance with our instructions. It is the responsibility of the buyer/user to ensure thatits activities comply with all applicable governmental requirements. Since conditions of use of the product are not underthe control of New England Biolabs, it is the duty of the buyer/user to determine the necessary conditions for the safe useof the product. New England Biolabs will not be liable for any damages resulting from handling or contact with theproduct.
End of Safety Data Sheet
_____________________________________________________________________________________________
Specification No No information available
Product name Enterokinase, lightchain
Page 9 / 9 Product No P8070
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006
Revision Date 17.03.2015 Version 3.0
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 9
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 108382
Product name Tris(hydroxymethyl)aminomethane GR for analysis buffer substance
ACS,Reag. Ph Eur
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.
CAS-No. 77-86-1
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Reagent for analysis
For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * 8th Floor, Godrej One,
Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079
India * Tel: 0091 22 6210 9000
Responsible Department Quality Assurance * Merck Life Science Private Limited *
e-mail: [email protected] *
Tel : +91-2267863131-6
1.4 Emergency telephone
number
Please contact the regional company representation in your country.
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
This substance is not classified as dangerous according to European Union legislation.
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
2.3 Other hazards
None known.
SECTION 3. Composition/information on ingredients
3.1 Substance
Formula H₂NC(CH₂OH)₃ C₄H₁₁NO₃ (Hill)
EC-No. 201-064-4
Molar mass 121.14 g/mol
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 108382
Product name Tris(hydroxymethyl)aminomethane GR for analysis buffer substance ACS,Reag.
Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 9
Remarks No disclosure requirement according to Regulation (EC) No.
1907/2006.
3.2 Mixture
Not applicable
SECTION 4. First aid measures
4.1 Description of first aid measures
After inhalation: fresh air.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower.
After eye contact: rinse out with plenty of water.
After swallowing: make victim drink water (two glasses at most). Consult doctor if feeling unwell.
4.2 Most important symptoms and effects, both acute and delayed
Nausea, Vomiting, Convulsions, Diarrhoea
The following applies to aliphatic amines in general: irritations after contact with eyes and skin.
Mucosal irritations, coughing, and dyspnoea after inhalation.
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SECTION 5. Firefighting measures
5.1 Extinguishing media
Suitable extinguishing mediaWater, Foam, Carbon dioxide (CO2), Dry powder
Unsuitable extinguishing mediaFor this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Combustible.
Development of hazardous combustion gases or vapours possible in the event of fire.
Fire may cause evolution of:
nitrogen oxides
5.3 Advice for firefighters
Special protective equipment for firefightersIn the event of fire, wear self-contained breathing apparatus.
Further informationSuppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing
water from contaminating surface water or the ground water system.
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid inhalation of dusts. Evacuate the danger area,
observe emergency procedures, consult an expert.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 108382
Product name Tris(hydroxymethyl)aminomethane GR for analysis buffer substance ACS,Reag.
Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 9
Advice for emergency responders:
Protective equipment see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see
sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation
of dusts.
6.4 Reference to other sections
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handlingObserve label precautions.
Hygiene measuresChange contaminated clothing. Wash hands after working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditionsTightly closed. Dry.
Recommended storage temperature see product label.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
Contains no substances with occupational exposure limit values.
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Eye/face protectionSafety glasses
Hand protection
full contact:
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 108382
Product name Tris(hydroxymethyl)aminomethane GR for analysis buffer substance ACS,Reag.
Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 4 of 9
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
splash contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 741 Dermatril® L (full contact),
KCL 741 Dermatril® L (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Respiratory protectionrequired when dusts are generated.
Recommended Filter type: Filter P 1 (acc. to DIN 3181) for solid particles of inert substances
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
Environmental exposure controls
Do not let product enter drains.
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
Form solid
Colour white
Odour odourless
Odour Threshold Not applicable
pH 10.2 - 10.6
at 6 g/l
20 °C
Melting point 168 - 172 °C
Boiling point/boiling range 219 - 220 °C
at 13.3 hPa
Flash point No information available.
Evaporation rate No information available.
Flammability (solid, gas) No information available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 108382
Product name Tris(hydroxymethyl)aminomethane GR for analysis buffer substance ACS,Reag.
Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 5 of 9
Lower explosion limit No information available.
Upper explosion limit No information available.
Vapour pressure 0.000267 Pa
at 20 °C
Relative vapour density No information available.
Density 1.353 g/cm³
at 23 °C
Relative density No information available.
Water solubility 800 g/l
at 20 °C
Partition coefficient: n-
octanol/water
log Pow: -2.31 (20 °C)
OECD Test Guideline 107
Bioaccumulation is not expected.
Auto-ignition temperature No information available.
Decomposition temperature No information available.
Viscosity, dynamic No information available.
Explosive properties Not classified as explosive.
Oxidizing properties none
9.2 Other data
Bulk density ca.840 kg/m³
SECTION 10. Stability and reactivity
10.1 Reactivity
The following applies in general to flammable organic substances and mixtures: in
correspondingly fine distribution, when whirled up a dust explosion potential may generally be
assumed.
10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.3 Possibility of hazardous reactions
Violent reactions possible with:
Oxidizing agents, Bases
Caution! In contact with nitrites, nitrates, nitrous acid possible liberation of nitosamines!
10.4 Conditions to avoid
no information available
10.5 Incompatible materials
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 108382
Product name Tris(hydroxymethyl)aminomethane GR for analysis buffer substance ACS,Reag.
Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 6 of 9
no information available
10.6 Hazardous decomposition products
in the event of fire: See section 5.
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Acute oral toxicityLD50 Rat: > 5,000 mg/kg
OECD Test Guideline 425
Acute inhalation toxicityThis information is not available.
Acute dermal toxicityLD50 Rat: > 5,000 mg/kg
OECD Test Guideline 402
Skin irritationRabbit
Result: No skin irritation
OECD Test Guideline 404
Eye irritationRabbit
Result: No eye irritation
OECD Test Guideline 405
SensitisationThis information is not available.
Germ cell mutagenicityThis information is not available.
CarcinogenicityThis information is not available.
Reproductive toxicityThis information is not available.
TeratogenicityThis information is not available.
Specific target organ toxicity - single exposureThis information is not available.
Specific target organ toxicity - repeated exposureThis information is not available.
Aspiration hazardThis information is not available.
11.2 Further information
After swallowing of large amounts:
Diarrhoea, Nausea, Vomiting, Convulsions
The following applies to aliphatic amines in general: irritations after contact with eyes and skin.
Mucosal irritations, coughing, and dyspnoea after inhalation., This substance should be handled
with particular care.
Under given conditions, contact with nitrites or nitric acid can lead to the formation of
nitrosamines, which have shown themselves to be carcinogenic in animal experiments.
However, when the product is handled appropriately, hazardous effects are unlikely to occur.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 108382
Product name Tris(hydroxymethyl)aminomethane GR for analysis buffer substance ACS,Reag.
Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 7 of 9
Handle in accordance with good industrial hygiene and safety practice.
SECTION 12. Ecological information
12.1 Toxicity
Toxicity to fishLC50 Leuciscus idus (Golden orfe): 460 mg/l; 96 h
OECD Test Guideline 203
Toxicity to daphnia and other aquatic invertebratesEC50 Daphnia magna (Water flea): > 980 mg/l; 48 h
OECD Test Guideline 202
Toxicity to algaeErC50 Pseudokirchneriella subcapitata (green algae): 397 mg/l; 72 h
OECD Test Guideline 201
Toxicity to bacteriaEC50 activated sludge: > 1,000 mg/l; 3 h
OECD Test Guideline 209
12.2 Persistence and degradability
Biodegradability89 %; 28 d
OECD Test Guideline 301D
Readily biodegradable
12.3 Bioaccumulative potential
Partition coefficient: n-octanol/waterlog Pow: -2.31 (20 °C)
OECD Test Guideline 107
Bioaccumulation is not expected.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.
12.6 Other adverse effects
Additional ecological informationDischarge into the environment must be avoided.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 108382
Product name Tris(hydroxymethyl)aminomethane GR for analysis buffer substance ACS,Reag.
Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 8 of 9
SECTION 13. Disposal considerations
Waste treatment methodsWaste material must be disposed of in accordance with the Directive on waste 2008/98/EC as
well as other national and local regulations. Leave chemicals in original containers. No mixing
with other waste. Handle uncleaned containers like the product itself.
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Sea transport (IMDG)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National legislation
Storage class 10 - 13
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Training advice
Provide adequate information, instruction and training for operators.
Labelling (67/548/EEC or 1999/45/EC)
Not a hazardous substance or mixture.
EC-No. 201-064-4
Key or legend to abbreviations and acronyms used in the safety data sheet
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 108382
Product name Tris(hydroxymethyl)aminomethane GR for analysis buffer substance ACS,Reag.
Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 9 of 9
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
The information contained herein is based on the present state of our knowledge. It characterises the product with regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Revision Date 11.07.2017 Version 3.1
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 18
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 108643
Product name Triton® X-100 suitable for the biopharmaceutical production
EMPROVE® bio Ph Eur
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.
CAS-No. 9036-19-5
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Pharmaceutical production, Reagent for analysis
For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * 8th Floor, Godrej One,
Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079
India * Tel: 0091 22 6210 9000
Responsible Department Quality Assurance * Merck Life Science Private Limited *
e-mail: [email protected] *
Tel : +91-2267863131-6
1.4 Emergency telephone
number
Please contact the regional company representation in your country.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 108643
Product name Triton® X-100 suitable for the biopharmaceutical production EMPROVE® bio
Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 18
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
Classification (REGULATION (EC) No 1272/2008)
Acute toxicity, Category 4, Oral, H302
Skin irritation, Category 2, H315
Serious eye damage, Category 1, H318
Acute aquatic toxicity, Category 1, H400
Chronic aquatic toxicity, Category 1, H410
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Hazard pictograms
Signal word
Danger
Hazard statements
H302 Harmful if swallowed.
H315 Causes skin irritation.
H318 Causes serious eye damage.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statements
Prevention
P273 Avoid release to the environment.
P280 Wear eye protection.
Response
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 108643
Product name Triton® X-100 suitable for the biopharmaceutical production EMPROVE® bio
Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 18
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
P313 Get medical advice/ attention.
Reduced labelling (≤125 ml)
Hazard pictograms
Signal word
Danger
Hazard statements
H318 Causes serious eye damage.
Precautionary statements
P280 Wear eye protection.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing.
P313 Get medical advice/ attention.
Contains: Octylphenol polyethoxyethanol
CAS-No. 9036-19-5
2.3 Other hazards
None known.
SECTION 3. Composition/information on ingredients
3.1 Substance
Formula C₈H₁₇C₆H₄(OCH₂CH₂)nOH C₁₄H₂₁(C₂H₄O)nOH (Hill)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 108643
Product name Triton® X-100 suitable for the biopharmaceutical production EMPROVE® bio
Ph Eur
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Page 4 of 18
Hazardous components (REGULATION (EC) No 1272/2008)
Chemical name (Concentration)
CAS-No. Registration number Classification
Octylphenol polyethoxyethanol (>= 50 % - <= 100 % )
9036-19-5 *)
Acute toxicity, Category 4, H302
Skin irritation, Category 2, H315
Serious eye damage, Category 1, H318
Acute aquatic toxicity, Category 1, H400
Chronic aquatic toxicity, Category 1, H410
M-Factor: 10
*) A registration number is not available for this substance as the substance or its use are exempted from registration according to Article
2 REACH Regulation (EC) No 1907/2006, the annual tonnage does not require a registration or the registration is envisaged for a later
registration deadline.
For the full text of the H-Statements mentioned in this Section, see Section 16.
3.2 Mixture
Not applicable
SECTION 4. First aid measures
4.1 Description of first aid measures
After inhalation: fresh air.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower.
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove
contact lenses.
After swallowing: caution if victim vomits. Risk of aspiration! Keep airways free. Pulmonary
failure possible after aspiration of vomit. Call a physician immediately.
4.2 Most important symptoms and effects, both acute and delayed
Dermatitis, Vomiting
Risk of corneal clouding.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 108643
Product name Triton® X-100 suitable for the biopharmaceutical production EMPROVE® bio
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Drying-out effect resulting in rough and chapped skin.
Irritation and corrosion
Risk of serious damage to eyes.
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SECTION 5. Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Water, Foam, Carbon dioxide (CO2), Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Combustible.
Vapours are heavier than air and may spread along floors.
Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
5.3 Advice for firefighters
Special protective equipment for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.
Further information
Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing
water from contaminating surface water or the ground water system.
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 108643
Product name Triton® X-100 suitable for the biopharmaceutical production EMPROVE® bio
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Advice for non-emergency personnel: Do not breathe vapours, aerosols. Avoid substance
contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency
procedures, consult an expert.
Advice for emergency responders:
Protective equipment see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see
sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb® ). Dispose of
properly. Clean up affected area.
6.4 Reference to other sections
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handling
Observe label precautions.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and
face after working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed.
Recommended storage temperature see product label.
7.3 Specific end use(s)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 108643
Product name Triton® X-100 suitable for the biopharmaceutical production EMPROVE® bio
Ph Eur
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Page 7 of 18
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
Contains no substances with occupational exposure limit values.
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Eye/face protection
Tightly fitting safety goggles
Hand protection
full contact:
Glove material: butyl-rubber
Glove thickness: 0.7 mm
Break through time: > 480 min
splash contact:
Glove material: butyl-rubber
Glove thickness: 0.7 mm
Break through time: > 480 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 898 Butoject® (full contact), KCL
898 Butoject® (splash contact).
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 108643
Product name Triton® X-100 suitable for the biopharmaceutical production EMPROVE® bio
Ph Eur
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Page 8 of 18
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Other protective equipment
protective clothing
Respiratory protection
required when vapours/aerosols are generated.
Recommended Filter type: Filter A-(P2)
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
Environmental exposure controls
Do not let product enter drains.
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
Form liquid
Colour colourless
Odour weak
Odour Threshold No information available.
pH 5.0 - 8.0
at 10 g/l
20 °C
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 108643
Product name Triton® X-100 suitable for the biopharmaceutical production EMPROVE® bio
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Page 9 of 18
Solidification point 6 °C
Boiling point/boiling range > 200 °C
at 1,013 hPa
Flash point 251 °C
at 1,013 hPa
Method: ASTM D 93
Evaporation rate No information available.
Flammability (solid, gas) No information available.
Lower explosion limit No information available.
Upper explosion limit No information available.
Vapour pressure < 0.01 hPa
at 20 °C
Relative vapour density No information available.
Density 1.07 g/cm3
at 20 °C
Relative density No information available.
Water solubility at 20 °C
soluble
Partition coefficient: n-
octanol/water
log Pow: 2.7 (20 °C)
(calculated)
(External MSDS) Bioaccumulation is not expected.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 108643
Product name Triton® X-100 suitable for the biopharmaceutical production EMPROVE® bio
Ph Eur
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Page 10 of 18
Auto-ignition temperature No information available.
Decomposition temperature No information available.
Viscosity, dynamic No information available.
Explosive properties Not classified as explosive.
Oxidizing properties none
9.2 Other data
Cloud point 63 - 69 °C
SECTION 10. Stability and reactivity
10.1 Reactivity
Forms explosive mixtures with air on intense heating.
A range from approx. 15 Kelvin below the flash point is to be rated as critical.
10.2 Chemical stability
In case of decomposition in closed containers and tubes risk of bursting due to buildup of
overpressure.
10.3 Possibility of hazardous reactions
Violent reactions possible with:
Strong oxidizing agents, Strong acids
10.4 Conditions to avoid
Strong heating.
10.5 Incompatible materials
no information available
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 108643
Product name Triton® X-100 suitable for the biopharmaceutical production EMPROVE® bio
Ph Eur
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Page 11 of 18
10.6 Hazardous decomposition products
in the event of fire: See section 5.
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Acute oral toxicity
LD50 Rat: 1,900 - 5,000 mg/kg
(External MSDS)
Symptoms: Vomiting, Irritations of mucous membranes in the mouth, pharynx, oesophagus and
gastrointestinal tract., Risk of aspiration upon vomiting., Aspiration may cause pulmonary
oedema and pneumonitis.
Acute inhalation toxicity
Symptoms: Possible damages:, mucosal irritations
Acute dermal toxicity
LD50 Rabbit: > 3,000 mg/kg
(External MSDS)
Skin irritation
Rabbit
Result: irritating
OECD Test Guideline 404
The value is given in analogy to the following substances: 4-(1,1,3,3-tetramethylbutyl)phenol
Causes skin irritation.
Drying-out effect resulting in rough and chapped skin. Dermatitis
Eye irritation
Risk of corneal clouding.
Causes serious eye damage.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 108643
Product name Triton® X-100 suitable for the biopharmaceutical production EMPROVE® bio
Ph Eur
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Page 12 of 18
Sensitisation
Sensitisation test: human
Result: negative
(External MSDS)
Germ cell mutagenicity
This information is not available.
Carcinogenicity
This information is not available.
Reproductive toxicity
This information is not available.
Teratogenicity
This information is not available.
Specific target organ toxicity - single exposure
This information is not available.
Specific target organ toxicity - repeated exposure
This information is not available.
Aspiration hazard
This information is not available.
11.2 Further information
After absorption:
We have no description of any toxic symptoms.
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
SECTION 12. Ecological information
12.1 Toxicity
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 108643
Product name Triton® X-100 suitable for the biopharmaceutical production EMPROVE® bio
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Page 13 of 18
Toxicity to fish
semi-static test LC50 Leuciscus idus (Golden orfe): 0.26 mg/l; 96 h
Analytical monitoring: yes
OECD Test Guideline 203
The value is given in analogy to the following substances: 4-(1,1,3,3-tetramethylbutyl)phenol
Toxicity to daphnia and other aquatic invertebrates
static test EC50 Daphnia magna (Water flea): 0.011 mg/l; 48 h
(ECOTOX Database) The value is given in analogy to the following substances: 4-(1,1,3,3-
tetramethylbutyl)phenol
Toxicity to algae
static test EC50 Pseudokirchneriella subcapitata (green algae): 1.9 mg/l; 96 h
(ECHA) The value is given in analogy to the following substances: 4-(1,1,3,3-
tetramethylbutyl)phenol
Toxicity to fish (Chronic toxicity)
flow-through test Danio rerio (zebra fish): 0.012 mg/l
Analytical monitoring: yes
OECD Test Guideline 210
The value is given in analogy to the following substances: 4-(1,1,3,3-tetramethylbutyl)phenol
Toxicity to daphnia and other aquatic invertebrates (Chronic toxicity)
semi-static test NOEC Daphnia magna (Water flea): 0.03 mg/l; 21 d
Analytical monitoring: yes
OECD Test Guideline 202
The value is given in analogy to the following substances: 4-(1,1,3,3-tetramethylbutyl)phenol
12.2 Persistence and degradability
Biodegradability
22 %; 28 d; aerobic
OECD Test Guideline 301C
Not readily biodegradable.
12.3 Bioaccumulative potential
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 108643
Product name Triton® X-100 suitable for the biopharmaceutical production EMPROVE® bio
Ph Eur
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Page 14 of 18
Partition coefficient: n-octanol/water
log Pow: 2.7 (20 °C)
(calculated)
(External MSDS) Bioaccumulation is not expected.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.
12.6 Other adverse effects
Additional ecological information
Causes endocrine disruption.
Discharge into the environment must be avoided.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 108643
Product name Triton® X-100 suitable for the biopharmaceutical production EMPROVE® bio
Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 15 of 18
SECTION 13. Disposal considerations
Waste treatment methods
Waste material must be disposed of in accordance with the national and local regulations. Leave
chemicals in original containers. No mixing with other waste. Handle uncleaned containers like
the product itself.
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 UN number UN 3082
14.2 Proper shipping name ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID,
N.O.S. (OCTYLPHENOXYPOLYETHOXYETHANOL)
14.3 Class 9
14.4 Packing group III
14.5 Environmentally hazardous yes
14.6 Special precautions for
user
yes
Tunnel restriction code -
Packages smaller than or equal to 5 kg / L , not dangerous goods of Class 9
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 108643
Product name Triton® X-100 suitable for the biopharmaceutical production EMPROVE® bio
Ph Eur
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Page 16 of 18
14.1 UN number UN 3082
14.2 Proper shipping name ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID,
N.O.S. (OCTYLPHENOXYPOLYETHOXYETHANOL)
14.3 Class 9
14.4 Packing group III
14.5 Environmentally hazardous yes
14.6 Special precautions for
user
no
Packages smaller than or equal to 5 kg / L , not dangerous goods of Class 9
Sea transport (IMDG)
14.1 UN number UN 3082
14.2 Proper shipping name ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID,
N.O.S. (OCTYLPHENOXYPOLYETHOXYETHANOL)
14.3 Class 9
14.4 Packing group III
14.5 Environmentally hazardous yes
14.6 Special precautions for
user
yes
EmS F-A S-F
Packages smaller than or equal to 5 kg / L , not dangerous goods of Class 9
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National legislation
Storage class 10 - 13
15.2 Chemical safety assessment
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 108643
Product name Triton® X-100 suitable for the biopharmaceutical production EMPROVE® bio
Ph Eur
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Page 17 of 18
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Full text of H-Statements referred to under sections 2 and 3.
H302 Harmful if swallowed.
H315 Causes skin irritation.
H318 Causes serious eye damage.
H400 Very toxic to aquatic life.
H410 Very toxic to aquatic life with long lasting effects.
Training advice
Provide adequate information, instruction and training for operators.
Labelling
Hazard pictograms
Signal word
Danger
Hazard statements
H302 Harmful if swallowed.
H315 Causes skin irritation.
H318 Causes serious eye damage.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statements
Prevention
P273 Avoid release to the environment.
P280 Wear eye protection.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 108643
Product name Triton® X-100 suitable for the biopharmaceutical production EMPROVE® bio
Ph Eur
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Page 18 of 18
Response
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
P313 Get medical advice/ attention.
Contains: Octylphenol polyethoxyethanol
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Revision Date 15.08.2017 Version 4.1
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 13
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 817072
Product name Tween® 20 (Polysorbate) EMPROVE® ESSENTIAL Ph Eur,JPE,NF
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.
CAS-No. 9005-64-5
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Pharmaceutical production, Chemical for synthesis, Cosmetic raw
material, Biocidal product
For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * 8th Floor, Godrej One,
Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079
India * Tel: 0091 22 6210 9000
Responsible Department Quality Assurance * Merck Life Science Private Limited *
e-mail: [email protected] *
Tel : +91-2267863131-6
1.4 Emergency telephone
number
Please contact the regional company representation in your country.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 817072
Product name Tween® 20 (Polysorbate) EMPROVE® ESSENTIAL Ph Eur,JPE,NF
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 13
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
This substance is not classified as dangerous according to European Union legislation.
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
2.3 Other hazards
None known.
SECTION 3. Composition/information on ingredients
3.1 Substance
Formula C₅₈H₁₁₄O₂₆ (Hill)
Molar mass 1,228 g/mol
Remarks No disclosure requirement according to Regulation (EC) No.
1907/2006.
3.2 Mixture
Not applicable
SECTION 4. First aid measures
4.1 Description of first aid measures
After inhalation: fresh air.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 817072
Product name Tween® 20 (Polysorbate) EMPROVE® ESSENTIAL Ph Eur,JPE,NF
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 13
After eye contact: rinse out with plenty of water. Remove contact lenses.
After swallowing: make victim drink water (two glasses at most). Consult doctor if feeling unwell.
4.2 Most important symptoms and effects, both acute and delayed
We have no description of any toxic symptoms.
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SECTION 5. Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Water, Foam, Carbon dioxide (CO2), Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Combustible.
Vapours are heavier than air and may spread along floors.
Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
5.3 Advice for firefighters
Special protective equipment for firefighters
In the event of fire, wear self-contained breathing apparatus.
Further information
Prevent fire extinguishing water from contaminating surface water or the ground water system.
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapours, aerosols. Evacuate the danger
area, observe emergency procedures, consult an expert.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 817072
Product name Tween® 20 (Polysorbate) EMPROVE® ESSENTIAL Ph Eur,JPE,NF
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 4 of 13
Advice for emergency responders:
Protective equipment see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see
sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb® ). Dispose of
properly. Clean up affected area.
6.4 Reference to other sections
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handling
Observe label precautions.
Hygiene measures
Change contaminated clothing. Wash hands after working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed.
Recommended storage temperature see product label.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 817072
Product name Tween® 20 (Polysorbate) EMPROVE® ESSENTIAL Ph Eur,JPE,NF
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 5 of 13
Contains no substances with occupational exposure limit values.
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Eye/face protection
Safety glasses
Hand protection
full contact:
Glove material: Nitrile rubber
Glove thickness: 0.40 mm
Break through time: > 480 min
splash contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 30 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 730 Camatril® -Velours (full
contact), KCL 741 Dermatril® L (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 817072
Product name Tween® 20 (Polysorbate) EMPROVE® ESSENTIAL Ph Eur,JPE,NF
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 6 of 13
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Respiratory protection
Not required; except in case of aerosol formation.
Environmental exposure controls
Do not let product enter drains.
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
Form liquid
Colour yellow
Odour odourless
Odour Threshold Not applicable
pH 6 - 8
at 50 g/l
20 °C
Melting point No information available.
Boiling point No information available.
Flash point 275 °C
at ca.1,013 hPa
Method: DIN 51758
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 817072
Product name Tween® 20 (Polysorbate) EMPROVE® ESSENTIAL Ph Eur,JPE,NF
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 7 of 13
Evaporation rate No information available.
Flammability (solid, gas) No information available.
Lower explosion limit No information available.
Upper explosion limit No information available.
Vapour pressure < 1.4 hPa
at 20 °C
Relative vapour density No information available.
Density 1.1 g/cm3
at 25 °C
Relative density No information available.
Water solubility < 0.2 mg/l
at 20 °C
Method: OECD Test Guideline 105
Partition coefficient: n-
octanol/water
No information available.
Auto-ignition temperature No information available.
Decomposition temperature No information available.
Viscosity, dynamic ca.400 mPa.s
at 25 °C
Explosive properties Not classified as explosive.
Oxidizing properties none
9.2 Other data
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 817072
Product name Tween® 20 (Polysorbate) EMPROVE® ESSENTIAL Ph Eur,JPE,NF
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 8 of 13
none
SECTION 10. Stability and reactivity
10.1 Reactivity
Forms explosive mixtures with air on intense heating.
A range from approx. 15 Kelvin below the flash point is to be rated as critical.
10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.3 Possibility of hazardous reactions
Violent reactions possible with:
Strong oxidizing agents
10.4 Conditions to avoid
Strong heating.
10.5 Incompatible materials
no information available
10.6 Hazardous decomposition products
no information available
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Acute oral toxicity
LD50 Rat: 38,900 mg/kg
(External MSDS)
Acute inhalation toxicity
LC50 Rat: > 5.1 mg/l; 4 h ; dust/mist
OECD Test Guideline 403
Limit Test (highest concentration to be prepared)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 817072
Product name Tween® 20 (Polysorbate) EMPROVE® ESSENTIAL Ph Eur,JPE,NF
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 9 of 13
Acute dermal toxicity
This information is not available.
Skin irritation
Rabbit
Result: No skin irritation
OECD Test Guideline 404
Eye irritation
This information is not available.
Sensitisation
Maximisation Test Guinea pig
Result: Does not cause skin sensitisation.
Method: OECD Test Guideline 406
Germ cell mutagenicity
Genotoxicity in vitro
Ames test
Escherichia coli/Salmonella typhimurium
Result: negative
Method: OECD Test Guideline 471
Mutagenicity (mammal cell test): chromosome aberration.
Human lymphocytes
Result: negative
Method: OECD Test Guideline 473
In vitro mammalian cell gene mutation test
Mouse lymphoma test
Result: negative
Method: OECD Test Guideline 476
Carcinogenicity
This information is not available.
Reproductive toxicity
This information is not available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 817072
Product name Tween® 20 (Polysorbate) EMPROVE® ESSENTIAL Ph Eur,JPE,NF
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 10 of 13
Teratogenicity
Application Route: Oral
Rat
Number of exposures: daily
Method: OECD Test Guideline 414
No indication of teratogenic properties.
Specific target organ toxicity - single exposure
This information is not available.
Specific target organ toxicity - repeated exposure
This information is not available.
Aspiration hazard
This information is not available.
11.2 Further information
Hazardous properties cannot be excluded but are unlikely when the product is handled
appropriately.
Handle in accordance with good industrial hygiene and safety practice.
SECTION 12. Ecological information
12.1 Toxicity
Toxicity to fish
static test LL50 Danio rerio (zebra fish): > 100 mg/l; 96 h
OECD Test Guideline 203
Toxicity to daphnia and other aquatic invertebrates
EC50 Daphnia (water flea): > 10 mg/l; 48 h
(above the solubility limit in the test medium) (Lit.)
Toxicity to algae
static test EL50 Pseudokirchneriella subcapitata (green algae): 58.84 mg/l; 72 h
OECD Test Guideline 201
static test EL10 Pseudokirchneriella subcapitata (green algae): 19.05 mg/l; 72 h
OECD Test Guideline 201
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 817072
Product name Tween® 20 (Polysorbate) EMPROVE® ESSENTIAL Ph Eur,JPE,NF
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 11 of 13
Toxicity to bacteria
microtox test EC50 Bacteria: 146 - 774 mg/l; 5 min
(Lit.)
Toxicity to daphnia and other aquatic invertebrates (Chronic toxicity)
semi-static test NOELR Daphnia magna (Water flea): 10 mg/l; 21 d
OECD Test Guideline 211
12.2 Persistence and degradability
Biodegradability
> 60 %; 28 d; aerobic
OECD Test Guideline 301F
Readily biodegradable
12.3 Bioaccumulative potential
No information available.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.
12.6 Other adverse effects
Additional ecological information
Discharge into the environment must be avoided.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 817072
Product name Tween® 20 (Polysorbate) EMPROVE® ESSENTIAL Ph Eur,JPE,NF
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 12 of 13
SECTION 13. Disposal considerations
Waste treatment methods
Waste material must be disposed of in accordance with the national and local regulations. Leave
chemicals in original containers. No mixing with other waste. Handle uncleaned containers like
the product itself.
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Sea transport (IMDG)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National legislation
Storage class 10 - 13
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 817072
Product name Tween® 20 (Polysorbate) EMPROVE® ESSENTIAL Ph Eur,JPE,NF
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 13 of 13
15.2 Chemical safety assessment
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Training advice
Provide adequate information, instruction and training for operators.
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Revision Date 08.06.2018 Version 1.2
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 16
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 102735
Product name L-Cysteine hydrochloride monohydrate suitable for use as excipient
EMPROVE® exp Ph Eur,USP
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.
CAS-No. 7048-04-6
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Pharmaceutical production, Cosmetic raw material
For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * 8th Floor, Godrej One,
Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079
India * Tel: 0091 22 6210 9000
Responsible Department Quality Assurance * Merck Life Science Private Limited *
e-mail: [email protected] *
Tel : +91-2267863131-6
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102735
Product name L-Cysteine hydrochloride monohydrate suitable for use as excipient
EMPROVE® exp Ph Eur,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 16
1.4 Emergency telephone
number
Please contact the regional company representation in your country.
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
Classification (REGULATION (EC) No 1272/2008)
Eye irritation, Category 2, H319
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Hazard pictograms
Signal word
Warning
Hazard statements
H319 Causes serious eye irritation.
Precautionary statements
Response
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
Reduced labelling (≤125 ml)
Hazard pictograms
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102735
Product name L-Cysteine hydrochloride monohydrate suitable for use as excipient
EMPROVE® exp Ph Eur,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 16
Signal word
Warning
CAS-No. 7048-04-6
2.3 Other hazards
None known.
SECTION 3. Composition/information on ingredients
3.1 Substance
Formula C₃H₈ClNO₂S * H₂O C₃H₈ClNO₂S * H₂O (Hill)
EC-No. 200-157-7
Molar mass 175.64 g/mol
Hazardous components (REGULATION (EC) No 1272/2008)
Chemical name (Concentration)
CAS-No. Registration number Classification
L-cysteine hydrochloride monohydrate (>= 80 % - <= 100 % )
7048-04-6 *)
Eye irritation, Category 2, H319
*) A registration number is not available for this substance as the substance or its use are exempted from registration according to Article
2 REACH Regulation (EC) No 1907/2006, the annual tonnage does not require a registration or the registration is envisaged for a later
registration deadline.
For the full text of the H-Statements mentioned in this Section, see Section 16.
3.2 Mixture
Not applicable
SECTION 4. First aid measures
4.1 Description of first aid measures
After inhalation: fresh air.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102735
Product name L-Cysteine hydrochloride monohydrate suitable for use as excipient
EMPROVE® exp Ph Eur,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 4 of 16
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower.
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.
After swallowing: immediately make victim drink water (two glasses at most). Consult a
physician.
4.2 Most important symptoms and effects, both acute and delayed
irritant effects
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SECTION 5. Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Water, Foam, Carbon dioxide (CO2), Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Combustible.
Development of hazardous combustion gases or vapours possible in the event of fire.
Fire may cause evolution of:
Hydrogen chloride gas, Sulphur oxides, nitrogen oxides
5.3 Advice for firefighters
Special protective equipment for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.
Further information
Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing
water from contaminating surface water or the ground water system.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102735
Product name L-Cysteine hydrochloride monohydrate suitable for use as excipient
EMPROVE® exp Ph Eur,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 5 of 16
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact. Ensure
adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an
expert.
Advice for emergency responders:
Protective equipment see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see
sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation
of dusts.
6.4 Reference to other sections
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handling
Observe label precautions.
Hygiene measures
Change contaminated clothing. Wash hands after working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed. Dry.
Recommended storage temperature see product label.
7.3 Specific end use(s)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102735
Product name L-Cysteine hydrochloride monohydrate suitable for use as excipient
EMPROVE® exp Ph Eur,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 6 of 16
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
Contains no substances with occupational exposure limit values.
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Eye/face protection
Safety glasses
Hand protection
full contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
splash contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 741 Dermatril® L (full contact),
KCL 741 Dermatril® L (splash contact).
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102735
Product name L-Cysteine hydrochloride monohydrate suitable for use as excipient
EMPROVE® exp Ph Eur,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 7 of 16
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Other protective equipment
protective clothing
Respiratory protection
required when dusts are generated.
Recommended Filter type: Filter P 2 (acc. to DIN 3181) for solid and liquid particles of harmful
substances
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
Environmental exposure controls
Do not let product enter drains.
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
Form solid
Colour white
Odour stinging
Odour Threshold No information available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102735
Product name L-Cysteine hydrochloride monohydrate suitable for use as excipient
EMPROVE® exp Ph Eur,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 8 of 16
pH 0.8 - 1.2
at 100 g/l
20 °C
Melting point 64 °C
at 1,013 hPa
Method: OECD Test Guideline 102
Boiling point/boiling range Method: OECD Test Guideline 103
(decomposition)
Flash point No information available.
Evaporation rate No information available.
Flammability (solid, gas) The product is not flammable.
Flammability (solids)
Lower explosion limit No information available.
Upper explosion limit No information available.
Vapour pressure < 0.1 hPa
at 20 °C
Method: OECD Test Guideline 104
Relative vapour density No information available.
Density 1.54 g/cm3
Method: OECD Test Guideline 109
Relative density No information available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102735
Product name L-Cysteine hydrochloride monohydrate suitable for use as excipient
EMPROVE® exp Ph Eur,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 9 of 16
Water solubility 660 g/l
at 23 °C
Method: OECD Test Guideline 105
Partition coefficient: n-
octanol/water
log Pow: -2.2 (23 °C)
OECD Test Guideline 107
Bioaccumulation is not expected.
Auto-ignition temperature No information available.
Decomposition temperature 110 °C
Viscosity, dynamic No information available.
Explosive properties Not classified as explosive.
Oxidizing properties none
9.2 Other data
Bulk density ca.780 kg/m3
Particle size Mean particle size
ca.269.7 µm
SECTION 10. Stability and reactivity
10.1 Reactivity
The following applies in general to flammable organic substances and mixtures: in
correspondingly fine distribution, when whirled up a dust explosion potential may generally be
assumed.
10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102735
Product name L-Cysteine hydrochloride monohydrate suitable for use as excipient
EMPROVE® exp Ph Eur,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 10 of 16
10.3 Possibility of hazardous reactions
Violent reactions possible with:
Oxidizing agents
10.4 Conditions to avoid
Strong heating (decomposition).
10.5 Incompatible materials
no information available
10.6 Hazardous decomposition products
in the event of fire: See section 5.
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Acute oral toxicity
LD50 Rat: > 2,000 mg/kg
OECD Test Guideline 423
Acute inhalation toxicity
This information is not available.
Acute dermal toxicity
LD50 Rat: > 2,000 mg/kg
OECD Test Guideline 402
Skin irritation
In vitro study
Result: No irritation
OECD Test Guideline 439
Eye irritation
In vitro study
Result: non-corrosive
OECD Test Guideline 437
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102735
Product name L-Cysteine hydrochloride monohydrate suitable for use as excipient
EMPROVE® exp Ph Eur,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 11 of 16
In vitro study
Result: positive
OECD Test Guideline 492
Causes serious eye irritation.
Sensitisation
Local lymph node assay (LLNA) Mouse
Result: negative
Method: OECD Test Guideline 429
Germ cell mutagenicity
Genotoxicity in vivo
Chromosome aberration test
Mouse
male
Intraperitoneal injection
Bone marrow
Result: negative
(Lit.) The value is given in analogy to the following substances: L-cysteine hydrochloride
Genotoxicity in vitro
Ames test
Salmonella typhimurium
Result: positive
Method: OECD Test Guideline 471
Carcinogenicity
This information is not available.
Reproductive toxicity
This information is not available.
Teratogenicity
This information is not available.
Specific target organ toxicity - single exposure
This information is not available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102735
Product name L-Cysteine hydrochloride monohydrate suitable for use as excipient
EMPROVE® exp Ph Eur,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 12 of 16
Specific target organ toxicity - repeated exposure
This information is not available.
Aspiration hazard
This information is not available.
11.2 Further information
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
SECTION 12. Ecological information
12.1 Toxicity
Toxicity to fish
static test LC50 Danio rerio (zebra fish): > 100 mg/l; 96 h
Analytical monitoring: yes
OECD Test Guideline 203
Toxicity to daphnia and other aquatic invertebrates
semi-static test EC50 Daphnia magna (Water flea): > 100 mg/l; 48 h
Analytical monitoring: yes
OECD Test Guideline 202
Toxicity to algae
static test EC50 Desmodesmus subspicatus (green algae): 40.1 mg/l; 72 h
Analytical monitoring: yes
OECD Test Guideline 201
static test EC10 Desmodesmus subspicatus (green algae): 7.5 mg/l; 72 h
Analytical monitoring: yes
OECD Test Guideline 201
Toxicity to bacteria
static test EC50 activated sludge: 360 mg/l; 3 h
OECD Test Guideline 209
12.2 Persistence and degradability
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102735
Product name L-Cysteine hydrochloride monohydrate suitable for use as excipient
EMPROVE® exp Ph Eur,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 13 of 16
Biodegradability
95.5 %; 9 d; aerobic
OECD Test Guideline 301A
Readily biodegradable
12.3 Bioaccumulative potential
Partition coefficient: n-octanol/water
log Pow: -2.2 (23 °C)
OECD Test Guideline 107
Bioaccumulation is not expected.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.
12.6 Other adverse effects
Additional ecological information
Discharge into the environment must be avoided.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102735
Product name L-Cysteine hydrochloride monohydrate suitable for use as excipient
EMPROVE® exp Ph Eur,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 14 of 16
SECTION 13. Disposal considerations
Waste treatment methods
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
Waste material must be disposed of in accordance with the national and local regulations. Leave
chemicals in original containers. No mixing with other waste. Handle uncleaned containers like
the product itself.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Sea transport (IMDG)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National legislation
Storage class 10 - 13
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102735
Product name L-Cysteine hydrochloride monohydrate suitable for use as excipient
EMPROVE® exp Ph Eur,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 15 of 16
15.2 Chemical safety assessment
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Full text of H-Statements referred to under sections 2 and 3.
H319 Causes serious eye irritation.
Training advice
Provide adequate information, instruction and training for operators.
Labelling
Hazard pictograms
Signal word
Warning
Hazard statements
H319 Causes serious eye irritation.
Precautionary statements
Response
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
Key or legend to abbreviations and acronyms used in the safety data sheet
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 102735
Product name L-Cysteine hydrochloride monohydrate suitable for use as excipient
EMPROVE® exp Ph Eur,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 16 of 16
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
Aldrich - 516732 Page 1 of 8
SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 03.11.2016
Print Date 18.06.2018 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA
SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1 Product identifiers Product name : 2-Mercaptoethanol
Product Number : 516732 Brand : Aldrich REACH No. : A registration number is not available for this substance as the substance
or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.
CAS-No. : 60-24-2
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances
1.3 Details of the supplier of the safety data sheet
Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA
1.4 Emergency telephone number
Emergency Phone # : +91 98802 05043
SECTION 2: Hazards identification
2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Oral (Category 3), H301 Acute toxicity, Inhalation (Category 3), H331 Acute toxicity, Dermal (Category 2), H310 Skin irritation (Category 2), H315 Serious eye damage (Category 1), H318 Skin sensitisation (Category 1), H317 Specific target organ toxicity - repeated exposure, Oral (Category 2), Liver, Heart, H373 Acute aquatic toxicity (Category 1), H400 Chronic aquatic toxicity (Category 1), H410
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008 Pictogram
Signal word Danger
Aldrich - 516732 Page 2 of 8
Hazard statement(s) H301 + H331 Toxic if swallowed or if inhaled H310 Fatal in contact with skin. H315 Causes skin irritation. H317 May cause an allergic skin reaction. H318 Causes serious eye damage. H373 May cause damage to organs (Liver, Heart) through prolonged or
repeated exposure if swallowed. H410 Very toxic to aquatic life with long lasting effects. Precautionary statement(s) P261 Avoid breathing vapours. P273 Avoid release to the environment. P280 Wear protective gloves/ eye protection/ face protection. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor. P302 + P350 IF ON SKIN: Gently wash with plenty of soap and water. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing. Supplemental Hazard Statements
none
2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. Stench. Stench., Rapidly absorbed through skin.
SECTION 3: Composition/information on ingredients
3.1 Substances Synonyms : beta mercaptoethanol
2-Hydroxyethylmercaptan 2ME Thioethylene glycol β-Mercaptoethanol BME
Formula : C2H6OS
Molecular weight : 78.13 g/mol CAS-No. : 60-24-2 EC-No. : 200-464-6 Hazardous ingredients according to Regulation (EC) No 1272/2008
Component Classification Concentration
2-Mercaptoethanol
CAS-No. EC-No.
60-24-2 200-464-6
Acute Tox. 3; Acute Tox. 2; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1; STOT RE 2; Aquatic Acute 1; Aquatic Chronic 1; H301, H331, H310, H315, H318, H317, H373, H400, H410
M-Factor - Aquatic Acute: 1
<= 100 %
For the full text of the H-Statements mentioned in this Section, see Section 16.
Aldrich - 516732 Page 3 of 8
SECTION 4: First aid measures
4.1 Description of first aid measures
General advice Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.
In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed No data available
SECTION 5: Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture Carbon oxides, Sulphur oxides
5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information Use water spray to cool unopened containers.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8.
6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.
6.3 Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13). Keep in suitable, closed containers for disposal.
6.4 Reference to other sections For disposal see section 13.
SECTION 7: Handling and storage
7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
Aldrich - 516732 Page 4 of 8
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
8.2 Exposure controls
Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.
Personal protective equipment
Eye/face protection Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 480 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) Splash contact Material: Nature latex/chloroprene Minimum layer thickness: 0.6 mm Break through time: 30 min Material tested:Lapren® (KCL 706 / Aldrich Z677558, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN 14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Aldrich - 516732 Page 5 of 8
Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.
SECTION 9: Physical and chemical properties
9.1 Information on basic physical and chemical properties
a) Appearance Form: liquid Colour: colourlessyellow
b) Odour Stench.
c) Odour Threshold No data available
d) pH 4.5 - 6 at 500 g/l at 20 °C
e) Melting point/freezing point
< -49.99 °C
f) Initial boiling point and boiling range
157 °C - lit.
g) Flash point 74 °C - closed cup
h) Evaporation rate No data available
i) Flammability (solid, gas) No data available
j) Upper/lower flammability or explosive limits
Upper explosion limit: 18 %(V) Lower explosion limit: 2.3 %(V)
k) Vapour pressure 0.76 mbar at 20 °C 4.67 mbar at 40 °C
l) Vapour density 2.70 - (Air = 1.0)
m) Relative density 1.114 g/cm3 at 25 °C
n) Water solubility soluble
o) Partition coefficient: n-octanol/water
log Pow: -0.326log Pow: -0.056 at 25 °C
p) Auto-ignition temperature
No data available
q) Decomposition temperature
No data available
r) Viscosity No data available
s) Explosive properties No data available
t) Oxidizing properties No data available
9.2 Other safety information
Relative vapour density 2.70 - (Air = 1.0)
SECTION 10: Stability and reactivity
10.1 Reactivity No data available
10.2 Chemical stability Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions No data available
Aldrich - 516732 Page 6 of 8
10.4 Conditions to avoid Heat, flames and sparks.
10.5 Incompatible materials Metals, Oxidizing agents
10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Sulphur oxides Other decomposition products - No data available In the event of fire: see section 5
SECTION 11: Toxicological information
11.1 Information on toxicological effects
Acute toxicity LD50 Oral - Rat - 98 - 162 mg/kg(2-Mercaptoethanol) (OECD Test Guideline 401) LC50 Inhalation - Rat - 4 h - 2 mg/l(2-Mercaptoethanol) LC50 Inhalation - Rat - 4 h - 625 ppm(2-Mercaptoethanol) LD50 Dermal - Rabbit - 112 mg/kg(2-Mercaptoethanol)
Skin corrosion/irritation Skin - Rabbit(2-Mercaptoethanol) Result: Irritating to skin. (Draize Test)
Serious eye damage/eye irritation Eyes - Rabbit(2-Mercaptoethanol) Result: Risk of serious damage to eyes.
Respiratory or skin sensitisation Maximisation Test - Guinea pig(2-Mercaptoethanol) May cause sensitisation by skin contact. (OECD Test Guideline 406)
Germ cell mutagenicity
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity No data available(2-Mercaptoethanol)
Specific target organ toxicity - single exposure No data available(2-Mercaptoethanol)
Specific target organ toxicity - repeated exposure Ingestion - May cause damage to organs through prolonged or repeated exposure. - Liver, Heart
Aspiration hazard No data available(2-Mercaptoethanol)
Additional Information RTECS: KL5600000 burning sensation, Cough, wheezing, laryngitis, Shortness of breath, Headache, Nausea, Vomiting, Weakness, Unconsciousness, Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema(2-Mercaptoethanol) To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(2-Mercaptoethanol)
Aldrich - 516732 Page 7 of 8
SECTION 12: Ecological information
12.1 Toxicity Toxicity to fish LC50 - Leuciscus idus (Golden orfe) - 46 - 100 mg/l - 96.0 h(2-
Mercaptoethanol) Toxicity to daphnia and other aquatic invertebrates
EC50 - Daphnia (water flea) - 0.89 mg/l - 48 h(2-Mercaptoethanol) (OECD Test Guideline 202)
Toxicity to algae EC50 - Desmodesmus subspicatus (green algae) - 12 mg/l - 72 h(2-
Mercaptoethanol) Toxicity to bacteria LC50 - Bacteria - 125 mg/l - 17 h(2-Mercaptoethanol)
12.2 Persistence and degradability Biodegradability Result: < 30.0 % - Not readily biodegradable. Result: 6 % - Not readily biodegradable. aerobic - Exposure time 28 d(2-Mercaptoethanol)
Result: < 10 % - Not readily biodegradable. Biochemical Oxygen Demand (BOD)
105 mg/g(2-Mercaptoethanol)
Chemical Oxygen Demand (COD)
1.894 mg/g(2-Mercaptoethanol)
12.3 Bioaccumulative potential Does not accumulate in organisms.
12.4 Mobility in soil No data available(2-Mercaptoethanol)
12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
12.6 Other adverse effects Very toxic to aquatic life with long lasting effects.
SECTION 13: Disposal considerations
13.1 Waste treatment methods
Product This combustible material may be burned in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging Dispose of as unused product.
SECTION 14: Transport information
14.1 UN number ADR/RID: 2966 IMDG: 2966 IATA: 2966
14.2 UN proper shipping name ADR/RID: THIOGLYCOL IMDG: THIOGLYCOL IATA: Thioglycol
14.3 Transport hazard class(es) ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1
14.4 Packaging group ADR/RID: II IMDG: II IATA: II
Aldrich - 516732 Page 8 of 8
14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user No data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out
SECTION 16: Other information
Full text of H-Statements referred to under sections 2 and 3.
H301 Toxic if swallowed. H301 + H331 Toxic if swallowed or if inhaled H310 Fatal in contact with skin. H315 Causes skin irritation. H317 May cause an allergic skin reaction. H318 Causes serious eye damage. H331 Toxic if inhaled. H373 May cause damage to organs through prolonged or repeated exposure if swallowed. H400 Very toxic to aquatic life. H410 Very toxic to aquatic life with long lasting effects.
Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.
Version: 1.2 Revision Date: 03-13-2018
SDS_US - SDS000001587 1/10
SAFETY DATA SHEET According to US Regulation 29 CFR 1910.1200 (HazCom 2012)
1. Identification
Product identifier: L-Arginine
Other means of identification
Product No.: 2066, 4932
Recommended restrictions
Recommended use: For Laboratory, Research or Manufacturing Use. Restrictions on use: Not determined.
Details of the supplier of the safety data sheet
Manufacturer
Company Name: Avantor Performance Materials, LLC. Address: 3477 Corporate Parkway
Center Valley, PA 18034
Telephone: Customer Service: 855-282-6867
Fax: 610-573-2610 Contact Person: Environmental Health & Safety E-mail: [email protected]
Emergency telephone number: CHEMTREC: 1-800-424-9300 within US and Canada
2. Hazard(s) identification
Hazard Classification
Health Hazards
Serious Eye Damage/Eye Irritation Category 2A
Unknown toxicity - Health
Acute toxicity, dermal 100 %
Acute toxicity, inhalation, vapor 100 %
Acute toxicity, inhalation, dust or mist
100 %
Hazard Symbol: No symbol
Signal Word: Warning
Hazard Statement: Causes eye irritation.
Label Elements
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SDS_US - SDS000001587 2/10
Precautionary Statements
Prevention: Wash hands thoroughly after handling.
Response: IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
Hazard(s) not otherwise classified (HNOC):
None.
3. Composition/information on ingredients
Substances
Chemical Identity CAS number Content in percent (%)*
L-Arginine 74-79-3 100% * All concentrations are percent by weight unless ingredient is a gas. Gas concentrations are in percent by volume.
4. First-aid measures
General information: Get medical advice/attention if you feel unwell. Show this safety data sheet
to the doctor in attendance. Ingestion: Rinse mouth. Call a POISON CENTER/doctor if you feel unwell.
Inhalation: Move to fresh air. Get medical attention if symptoms persist.
Skin Contact: Wash skin thoroughly with soap and water. Get medical attention if
symptoms occur. Eye contact: Immediately flush with plenty of water for at least 15 minutes. If easy to do,
remove contact lenses. Get medical attention. Most important symptoms/effects, acute and delayed
Symptoms: Irritating to eyes, respiratory system and skin.
Hazards: None known.
Indication of immediate medical attention and special treatment needed
Treatment: Treat symptomatically.
5. Fire-fighting measures
General Fire Hazards: No unusual fire or explosion hazards noted.
Suitable (and unsuitable) extinguishing media
Suitable extinguishing media:
Extinguish with foam, carbon dioxide, dry powder or water fog.
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SDS_US - SDS000001587 3/10
Unsuitable extinguishing media:
None known.
Specific hazards arising from
the chemical: During fire, gases hazardous to health may be formed.
Special protective equipment and precautions for firefighters
Special fire fighting procedures:
Move containers from fire area if you can do so without risk. Use water spray to keep fire-exposed containers cool. Cool containers exposed to flames with water until well after the fire is out.
Special protective equipment for fire-fighters:
Firefighters must use standard protective equipment including flame retardant coat, helmet with face shield, gloves, rubber boots, and in enclosed spaces, SCBA.
6. Accidental release measures
Personal precautions,
protective equipment and emergency procedures:
Keep unauthorized personnel away. Ventilate closed spaces before entering them. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Avoid inhalation of dust. See Section 8 of the SDS for Personal Protective Equipment.
Methods and material for
containment and cleaning up:
Sweep up and place in a clearly labeled container for chemical waste. Clean surface thoroughly to remove residual contamination.
Notification Procedures: Prevent entry into waterways, sewer, basements or confined areas. Stop
the flow of material, if this is without risk. Inform authorities if large amounts are involved.
Environmental Precautions: Do not contaminate water sources or sewer. Prevent further leakage or
spillage if safe to do so.
7. Handling and storage
Precautions for safe handling: Avoid contact with eyes, skin, and clothing. Avoid inhalation of dust. Wash
hands thoroughly after handling. See Section 8 of the SDS for Personal Protective Equipment.
Conditions for safe storage,
including any incompatibilities:
Keep container tightly closed in a cool, well-ventilated place.
8. Exposure controls/personal protection
Control Parameters
Occupational Exposure Limits None of the components have assigned exposure limits.
Appropriate Engineering
Controls No data available.
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SDS_US - SDS000001587 4/10
Individual protection measures, such as personal protective equipment
General information: Good general ventilation (typically 10 air changes per hour) should be used. Ventilation rates should be matched to conditions. If applicable, use process enclosures, local exhaust ventilation, or other engineering controls to maintain airborne levels below recommended exposure limits. If exposure limits have not been established, maintain airborne levels to an acceptable level.
Eye/face protection: Wear safety glasses with side shields (or goggles).
Skin Protection
Hand Protection: Chemical resistant gloves
Other: Wear suitable protective clothing.
Respiratory Protection: In case of inadequate ventilation use suitable respirator.
Hygiene measures: Provide eyewash station and safety shower. Always observe good personal hygiene measures, such as washing after handling the material and before eating, drinking, and/or smoking. Routinely wash work clothing to remove contaminants. Discard contaminated footwear that cannot be cleaned.
9. Physical and chemical properties
Appearance
Physical state: Solid
Form: Crystals or powder.
Color: Colorless
Odor: Odorless
Odor threshold: No data available.
pH: No data available.
Melting point/freezing point: 223 - 224 °C
Initial boiling point and boiling range: No data available.
Flash Point: No data available.
Evaporation rate: No data available.
Flammability (solid, gas): No data available.
Upper/lower limit on flammability or explosive limits
Flammability limit - upper (%): No data available.
Flammability limit - lower (%): No data available.
Explosive limit - upper (%): No data available.
Explosive limit - lower (%): No data available.
Vapor pressure: No data available.
Vapor density: No data available.
Density: 1.46 g/cm3 (20 °C)
Relative density: 1.46 (20 °C)
Solubility(ies)
Solubility in water: 182 g/l (25 °C)
Solubility (other): ethanol: Slightly Soluble ethyl ether: Insoluble
Partition coefficient (n-octanol/water): -4.20
Auto-ignition temperature: 380 °C
Decomposition temperature: No data available.
Viscosity: No data available.
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SDS_US - SDS000001587 5/10
Other information
Molecular weight: 174.2 g/mol (C6H14N4O2)
10. Stability and reactivity
Reactivity: No dangerous reaction known under conditions of normal use.
Chemical Stability: Material is stable under normal conditions.
Possibility of hazardous
reactions: Hazardous polymerization does not occur.
Conditions to avoid: Contact with incompatible materials.
Incompatible Materials: Strong oxidizing agents.
Hazardous Decomposition
Products: Thermal decomposition may produce oxides of carbon and nitrogen.
11. Toxicological information
Information on likely routes of exposure
Inhalation: Dust may irritate respiratory system.
Skin Contact: May cause irritation.
Eye contact: Causes eye irritation.
Ingestion: May cause irritation of the gastrointestinal tract.
Information on toxicological effects
Acute toxicity (list all possible routes of exposure)
Oral Product: LD 50 (Rat): 3,792 mg/kg
Dermal
Product: No data available.
Inhalation Product: No data available.
Repeated dose toxicity Product: No data available.
Skin Corrosion/Irritation Product: May cause skin irritation.
Serious Eye Damage/Eye Irritation
Product: Causes eye irritation.
Respiratory or Skin Sensitization Product: Not a skin sensitizer.
Carcinogenicity
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SDS_US - SDS000001587 6/10
Product: This substance has no evidence of carcinogenic properties.
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: No carcinogenic components identified
US. National Toxicology Program (NTP) Report on Carcinogens: No carcinogenic components identified
US. OSHA Specifically Regulated Substances (29 CFR 1910.1001-1050): No carcinogenic components identified
Germ Cell Mutagenicity
In vitro Product: No mutagenic components identified
In vivo
Product: No mutagenic components identified
Reproductive toxicity Product: No components toxic to reproduction
Specific Target Organ Toxicity - Single Exposure
Product: Respiratory tract irritation.
Specific Target Organ Toxicity - Repeated Exposure Product: None known.
Aspiration Hazard
Product: Not classified
Other effects: None known.
12. Ecological information
Ecotoxicity:
Acute hazards to the aquatic environment:
Fish Product: No data available.
Specified substance(s):
L-Arginine NOAEL (Danio rerio, 96 h): 1.8 g/l LC 50 (Danio rerio, 96 h): 2.8 g/l
Aquatic Invertebrates
Product: No data available.
Specified substance(s): L-Arginine EC 50 (Daphnia magna, 24 h): 1.8 g/l
NOAEL (Daphnia magna, 24 h): 1 g/l
Chronic hazards to the aquatic environment:
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SDS_US - SDS000001587 7/10
Fish Product: No data available.
Aquatic Invertebrates Product: No data available.
Toxicity to Aquatic Plants Product: No data available.
Persistence and Degradability
Biodegradation Product: There are no data on the degradability of this product.
BOD/COD Ratio
Product: No data available.
Bioaccumulative potential Bioconcentration Factor (BCF)
Product: No data available on bioaccumulation. Partition Coefficient n-octanol / water (log Kow)
Product: Log Kow: -4.20 Mobility in soil: The product is water soluble and may spread in water systems.
Other adverse effects: The product components are not classified as environmentally hazardous.
However, this does not exclude the possibility that large or frequent spills can have a harmful or damaging effect on the environment.
13. Disposal considerations
Disposal instructions: Discharge, treatment, or disposal may be subject to national, state, or local
laws. Contaminated Packaging: Since emptied containers retain product residue, follow label warnings even
after container is emptied.
14. Transport information
DOT
Not regulated.
IMDG Not regulated.
IATA
Not regulated.
15. Regulatory information
US Federal Regulations
TSCA Section 12(b) Export Notification (40 CFR 707, Subpt. D) None present or none present in regulated quantities.
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SDS_US - SDS000001587 8/10
US. OSHA Specifically Regulated Substances (29 CFR 1910.1001-1050) None present or none present in regulated quantities.
CERCLA Hazardous Substance List (40 CFR 302.4): None present or none present in regulated quantities.
Superfund Amendments and Reauthorization Act of 1986 (SARA)
Hazard categories
Serious eye damage or eye irritation
SARA 302 Extremely Hazardous Substance None present or none present in regulated quantities.
SARA 304 Emergency Release Notification
None present or none present in regulated quantities.
SARA 311/312 Hazardous Chemical Chemical Identity Threshold Planning Quantity L-Arginine 10000 lbs.
SARA 313 (TRI Reporting) None present or none present in regulated quantities.
Clean Air Act (CAA) Section 112(r) Accidental Release Prevention (40 CFR 68.130):
None present or none present in regulated quantities. None present or none present in regulated quantities.
Chemical Identity Reportable quantity Clean Water Act Section 311 Hazardous Substances (40 CFR 117.3):
None present or none present in regulated quantities. None present or none present in regulated quantities.
US State Regulations
US. California Proposition 65
No ingredient regulated by CA Prop 65 present.
US. New Jersey Worker and Community Right-to-Know Act No ingredient regulated by NJ Right-to-Know Law present.
US. Massachusetts RTK - Substance List
No ingredient regulated by MA Right-to-Know Law present.
US. Pennsylvania RTK - Hazardous Substances No ingredient regulated by PA Right-to-Know Law present.
US. Rhode Island RTK
No ingredient regulated by RI Right-to-Know Law present. International regulations
Montreal protocol
not applicable
Stockholm convention
not applicable
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SDS_US - SDS000001587 9/10
Rotterdam convention
not applicable
Kyoto protocol not applicable
Inventory Status:
Australia AICS: On or in compliance with the inventory Canada DSL Inventory List: On or in compliance with the inventory EINECS, ELINCS or NLP: On or in compliance with the inventory Japan (ENCS) List: On or in compliance with the inventory Korea Existing Chemicals Inv. (KECI): On or in compliance with the inventory Philippines PICCS: On or in compliance with the inventory US TSCA Inventory: On or in compliance with the inventory New Zealand Inventory of Chemicals: On or in compliance with the inventory Japan ISHL Listing: On or in compliance with the inventory China Inv. Existing Chemical Substances: On or in compliance with the inventory Mexico INSQ: On or in compliance with the inventory Taiwan Chemical Substance Inventory: On or in compliance with the inventory
16.Other information, including date of preparation or last revision
Issue Date: 03-13-2018
Revision Information: Not relevant.
Version #: 1.2
Source of information: Sources of information used in preparing this SDS included one or more of the following: results from in house or supplier toxicology studies, information from the Toxicology Data Network (TOXNET), European Chemical Agency (ECHA) substance dossiers, IARC Monographs, US National Toxicology Program data, the Agency for Toxic Substances and Disease Registry, other manufacturer’s SDSs and other sources, as appropriate.
Further Information: No data available.
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SDS_US - SDS000001587 10/10
Disclaimer: The information provided in this Safety Data Sheet (SDS) was prepared based on data believed to be accurate as of the date of this SDS. TO THE GREATEST EXTENT PERMITTED BY LAW, AVANTOR PERFORMANCE MATERIALS (“AVANTOR”) EXPRESSLY DISCLAIMS ANY AND ALL REPRESENTATIONS AND WARRANTIES REGARDING THE INFORMATION CONTAINED HEREIN INCLUDING, WITHOUT LIMITATION, AS TO ACCURACY, COMPLETENESS, FITNESS FOR PURPOSE OR USE, MERCHANTABILITY, NON-INFRINGEMENT, PERFORMANCE, SAFETY, SUITABILITY AND STABILITY. This SDS is intended as a guide to the appropriate use, handling, storage and disposal of the product to which it relates by properly trained personnel, and is not intended to be comprehensive. Users of Avantor’s products are advised to perform their own tests and to exercise their own judgment to determine the safety, suitability and appropriate use, handling, storage and disposal of each product and product combination for their own purposes and uses. TO THE GREATEST EXTENT PERMITTED BY LAW, AVANTOR DISCLAIMS LIABILITY FOR, AND BY USING AVANTOR’S PRODUCTS PURCHASER AGREES THAT UNDER NO CIRCUMSTANCES SHALL AVANTOR BE LIABLE FOR, SPECIAL, INDIRECT, INCIDENTAL , PUNITIVE OR CONSEQUENTIAL DAMAGES OF ANY TYPE OR KIND, INCLUDING WITHOUT LIMITATION, FOR LOSS OF PROFITS, REPUTATIONAL DAMAGE, PRODUCT RECALL OR BUSINESS INTERRUPTION.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Revision Date 12.12.2016 Version 2.1
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 24
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. D45399
Product code 4015
Product name Imidazole, ULTROL® Grade
REACH Registration Number 01-2119485825-24-XXXX
CAS-No. 288-32-4
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Reagent for development and research
In compliance with the conditions described in the annex to this safety
data sheet.
1.3 Details of the supplier of the safety data sheet
Company Merck KGaA * 64271 Darmstadt * Germany * Phone:+49 6151 72-0
Responsible Department LS-QHC * e-mail: [email protected]
1.4 Emergency telephone
number
Please contact the regional company representation in your country.
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
Classification (REGULATION (EC) No 1272/2008)
Acute toxicity, Category 4, Oral, H302
Skin corrosion, Category 1C, H314
Reproductive toxicity, Category 1B, H360D
For the full text of the H-Statements mentioned in this Section, see Section 16.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. D45399
Product name Imidazole, ULTROL® Grade
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 24
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Hazard pictograms
Signal word
Danger
Hazard statements
H360D May damage the unborn child.
H302 Harmful if swallowed.
H314 Causes severe skin burns and eye damage.
Precautionary statements
Prevention
P201 Obtain special instructions before use.
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
Response
P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.
Restricted to professional users.
Reduced labelling (≤125 ml)
Hazard pictograms
Signal word
Danger
Hazard statements
H360D May damage the unborn child.
H314 Causes severe skin burns and eye damage.
Precautionary statements
P201 Obtain special instructions before use.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. D45399
Product name Imidazole, ULTROL® Grade
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 24
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing.
P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.
Contains: Imidazole
Index-No. 613-319-00-0
2.3 Other hazards
None known.
SECTION 3. Composition/information on ingredients
3.1 Substance
Formula C₃H₄N₂ (Hill)
Index-No. 613-319-00-0
EC-No. 206-019-2
Molar mass 68,08 g/mol
Hazardous components (REGULATION (EC) No 1272/2008)
Chemical Name (Concentration)
CAS-No. Registration number Classification
Imidazole (<= 100 % )
Substance does not meet the criteria for PBT or vPvB according to Regulation (EC) No 1907/2006, Annex XIII.
288-32-4 01-2119485825-24-
XXXX
Acute toxicity, Category 4, H302
Skin corrosion, Category 1C, H314
Reproductive toxicity, Category 1B, H360D
For the full text of the H-Statements mentioned in this Section, see Section 16.
3.2 Mixture
Not applicable
SECTION 4. First aid measures
4.1 Description of first aid measures
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. D45399
Product name Imidazole, ULTROL® Grade
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 4 of 24
General advice
First aider needs to protect himself.
After inhalation: fresh air. Call in physician.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower. Call a physician immediately.
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist.
After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of
perforation). Do not attempt to neutralise. Call a physician immediately.
4.2 Most important symptoms and effects, both acute and delayed
Irritation and corrosion, Cough, Shortness of breath
Risk of blindness!
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SECTION 5. Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Water, Carbon dioxide (CO2), Foam, Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Combustible.
Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
Fire may cause evolution of:
nitrous gases, nitrogen oxides
5.3 Advice for firefighters
Special protective equipment for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. D45399
Product name Imidazole, ULTROL® Grade
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 5 of 24
Further information
Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing
water from contaminating surface water or the ground water system.
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid substance contact. Avoid inhalation of dusts. Ensure
adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an
expert.
Advice for emergency responders: Protective equipment see section 8.
6.2 Environmental precautions
Do not empty into drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills.
Observe possible material restrictions (see sections 7 and 10).
Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.
6.4 Reference to other sections
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handling
Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Observe label precautions.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and
face after working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only
to qualified or authorised persons.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. D45399
Product name Imidazole, ULTROL® Grade
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 6 of 24
Recommended storage temperature see product label.
7.3 Specific end use(s)
See exposure scenario in the Annex to this MSDS.
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
Derived No Effect Level (DNEL)
Worker DNEL, longterm Systemic effects inhalation 10,6 mg/m³
Worker DNEL, longterm Systemic effects dermal 1,5 mg/kg Body weight
Predicted No Effect Concentration (PNEC)
PNEC Fresh water 0,13 mg/l
PNEC Marine water 0,013 mg/l
PNEC Aquatic intermittent release 1,3 mg/l
PNEC Fresh water sediment 0,336 mg/kg
PNEC Marine sediment 0,0336 mg/kg
PNEC Soil 0,0425 mg/kg
PNEC Sewage treatment plant 10 mg/l
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. D45399
Product name Imidazole, ULTROL® Grade
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 7 of 24
Eye/face protection
Tightly fitting safety goggles
Hand protection
full contact:
Glove material: Nitrile rubber
Glove thickness: 0,11 mm
Break through time: > 480 min
splash contact:
Glove material: Nitrile rubber
Glove thickness: 0,11 mm
Break through time: > 480 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 741 Dermatril® L (full contact),
KCL 741 Dermatril® L (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Other protective equipment
protective clothing
Respiratory protection
required when dusts are generated.
Recommended Filter type: Filter P 3 (acc. to DIN 3181) for solid and liquid particles of toxic
and very toxic substances
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
Environmental exposure controls
Do not empty into drains.
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. D45399
Product name Imidazole, ULTROL® Grade
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 8 of 24
Form solid
Colour light yellow
Odour amine-like
Odour Threshold No information available.
pH 10,5
at 67 g/l
20 °C
Melting point 90 °C
Method: OECD Test Guideline 102
Boiling point/boiling range 268 °C
at 1.013 hPa
(ECHA)
Flash point 145 °C
Method: DIN 51758
Evaporation rate No information available.
Flammability (solid, gas) The product is not flammable.
Flammability (solids)
Lower explosion limit No information available.
Upper explosion limit No information available.
Vapour pressure 0,003 hPa
at 20 °C
Method: OECD Test Guideline 104
Relative vapour density No information available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. D45399
Product name Imidazole, ULTROL® Grade
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 9 of 24
Density 1,233 g/cm3
at 20 °C
Method: OECD Test Guideline 109
Relative density No information available.
Water solubility 633 g/l
at 20 °C
Partition coefficient: n-
octanol/water
log Pow: -0,02
OECD Test Guideline 107
Bioaccumulation is not expected. (Lit.)
Auto-ignition temperature No information available.
Decomposition temperature No information available.
Viscosity, dynamic 2,696 mPa.s
at 100 °C
Explosive properties Not classified as explosive.
Oxidizing properties none
9.2 Other data
Ignition temperature 480 °C
Method: DIN 51794
Bulk density 500 - 600 kg/m3
Particle size Mean particle size
ca.1 mm
SECTION 10. Stability and reactivity
10.1 Reactivity
Forms explosive mixtures with air on intense heating.
A range from approx. 15 Kelvin below the flash point is to be rated as critical.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. D45399
Product name Imidazole, ULTROL® Grade
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 10 of 24
The following applies in general to flammable organic substances and mixtures: in
correspondingly fine distribution, when whirled up a dust explosion potential may generally be
assumed.
10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.3 Possibility of hazardous reactions
Violent reactions possible with:
Strong oxidizing agents, Acid chlorides, Acid anhydrides, acids
10.4 Conditions to avoid
Strong heating.
10.5 Incompatible materials
no information available
10.6 Hazardous decomposition products
in the event of fire: See section 5.
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Acute oral toxicity
LD50 Rat: 970 mg/kg
OECD Test Guideline 401
Symptoms: If ingested, severe burns of the mouth and throat, as well as a danger of perforation
of the oesophagus and the stomach.
absorption
Acute inhalation toxicity
Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of
respiratory tract, Lung oedema
Acute dermal toxicity
This information is not available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. D45399
Product name Imidazole, ULTROL® Grade
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 11 of 24
Skin irritation
Rabbit
Result: Corrosive
OECD Test Guideline 404
Burns after prolonged exposure.
Eye irritation
Rabbit
Result: Causes serious eye damage.
OECD Test Guideline 405
Causes serious eye damage.
Risk of blindness!
Sensitisation
This information is not available.
Germ cell mutagenicity
Genotoxicity in vivo
In vivo micronucleus test
Mouse
male and female
Oral
Bone marrow
Result: negative
Method: OECD Test Guideline 474
Genotoxicity in vitro
unscheduled DNA synthesis assay
rat hepatocytes
Result: negative
Method: OECD Test Guideline 482
Ames test
Salmonella typhimurium
Result: negative
Method: OECD Test Guideline 471
In vitro mammalian cell gene mutation test
Chinese hamster lung cells
Result: negative
Method: OECD Test Guideline 476
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. D45399
Product name Imidazole, ULTROL® Grade
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 12 of 24
Carcinogenicity
This information is not available.
Reproductive toxicity
This information is not available.
Teratogenicity
This information is not available.
CMR effects
Teratogenicity:
May damage the unborn child.
Specific target organ toxicity - single exposure
This information is not available.
Specific target organ toxicity - repeated exposure
This information is not available.
Aspiration hazard
This information is not available.
11.2 Further information
After absorption:
We have no description of any toxic symptoms.
Other dangerous properties can not be excluded.
This substance should be handled with particular care.
SECTION 12. Ecological information
12.1 Toxicity
Toxicity to fish
LC50 Leuciscus idus (Golden orfe): ca. 280 mg/l; 48 h
DIN 37 412 T 15
(External MSDS)
Toxicity to daphnia and other aquatic invertebrates
static test EC50 Daphnia magna (Water flea): 341,5 mg/l; 48 h
OECD Test Guideline 202
Toxicity to algae
static test ErC50 Desmodesmus subspicatus (green algae): 133 mg/l; 72 h
DIN 38412
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. D45399
Product name Imidazole, ULTROL® Grade
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 13 of 24
Toxicity to bacteria
Respiration inhibition EC50 activated sludge: > 1.000 mg/l; 30 min
OECD Test Guideline 209
12.2 Persistence and degradability
Biodegradability
90 - 100 %; 18 d; aerobic
OECD Test Guideline 301A
Readily biodegradable
12.3 Bioaccumulative potential
Partition coefficient: n-octanol/water
log Pow: -0,02
OECD Test Guideline 107
Bioaccumulation is not expected. (Lit.)
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
Substance does not meet the criteria for PBT or vPvB according to Regulation (EC) No
1907/2006, Annex XIII.
12.6 Other adverse effects
Additional ecological information
When discharged properly, no impairments in the function of adapted biological wastewater
treatment plants are to be expected.
Depending on the concentration, phosphorus and/or nitrogen compounds may contribute to the
eutrophication of drinking- water supplies.
Discharge into the environment must be avoided.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. D45399
Product name Imidazole, ULTROL® Grade
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 14 of 24
SECTION 13. Disposal considerations
Waste treatment methods
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 UN number UN 3263
14.2 Proper shipping name CORROSIVE SOLID, BASIC, ORGANIC, N.O.S.
(IMIDAZOLE)
14.3 Class 8
14.4 Packing group III
14.5 Environmentally hazardous --
14.6 Special precautions for
user
yes
Tunnel restriction code E
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)
14.1 UN number UN 3263
14.2 Proper shipping name CORROSIVE SOLID, BASIC, ORGANIC, N.O.S.
(IMIDAZOLE)
14.3 Class 8
14.4 Packing group III
14.5 Environmentally hazardous --
14.6 Special precautions for
user
no
Sea transport (IMDG)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. D45399
Product name Imidazole, ULTROL® Grade
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 15 of 24
14.1 UN number UN 3263
14.2 Proper shipping name CORROSIVE SOLID, BASIC, ORGANIC, N.O.S.
(IMIDAZOLE)
14.3 Class 8
14.4 Packing group III
14.5 Environmentally hazardous --
14.6 Special precautions for
user
yes
EmS F-A S-B
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
EU regulations
Major Accident Hazard
Legislation
SEVESO III
Not applicable
Occupational restrictions Take note of Dir 94/33/EC on the protection of young people at
work. Observe work restrictions regarding maternity protection in
accordance to Dir 92/85/EEC or stricter national regulations where
applicable.
Regulation (EC) No 1005/2009 on substances that
deplete the ozone layer
not regulated
Regulation (EC) No 850/2004 of the European
Parliament and of the Council of 29 April 2004 on
persistent organic pollutants and amending
Directive 79/117/EEC
not regulated
Substances of very high concern (SVHC) This product does not contain substances
of very high concern according to
Regulation (EC) No 1907/2006 (REACH),
Article 57 above the respective regulatory
concentration limit of ≥ 0.1 % (w/w).
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. D45399
Product name Imidazole, ULTROL® Grade
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 16 of 24
National legislation
Storage class 6.1C
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Full text of H-Statements referred to under sections 2 and 3.
H302 Harmful if swallowed.
H314 Causes severe skin burns and eye damage.
H360D May damage the unborn child.
Training advice
Provide adequate information, instruction and training for operators.
Labelling
Hazard pictograms
Signal word
Danger
Hazard statements
H302 Harmful if swallowed.
H314 Causes severe skin burns and eye damage.
H360 May damage fertility or the unborn child.
Precautionary statements
Prevention
P201 Obtain special instructions before use.
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
Response
P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. D45399
Product name Imidazole, ULTROL® Grade
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 17 of 24
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.
Further information
Restricted to professional users.
Contains: Imidazole
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
Regional representation
This information is given on the authorised Safety Data Sheet for your country.
The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
SAFETY DATA SHEET – Annex
according to Regulation (EC) No. 1907/2006
Catalogue No. D45399
Product name Imidazole, ULTROL® Grade
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 18 of 24
EXPOSURE SCENARIO 1 (Industrial use)
1. Industrial use Reagent for development and research)
Sectors of end-use
SU 3 Industrial uses: Uses of substances as such or in preparations at industrial sites
SU9 Manufacture of fine chemicals
SU 10 Formulation [mixing] of preparations and/ or re-packaging (excluding alloys)
Chemical product category
PC21 Laboratory chemicals
Process categories
PROC1 Use in closed process, no likelihood of exposure
PROC2 Use in closed, continuous process with occasional controlled exposure
PROC3 Use in closed batch process (synthesis or formulation)
PROC4 Use in batch and other process (synthesis) where opportunity for exposure arises
PROC5 Mixing or blending in batch processes for formulation of preparations and articles
(multistage and/ or significant contact)
PROC8a Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large
containers at non-dedicated facilities
PROC8b Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large
containers at dedicated facilities
PROC9 Transfer of substance or preparation into small containers (dedicated filling line, including
weighing)
PROC10 Roller application or brushing
PROC15 Use as laboratory reagent
Environmental Release Categories
ERC1 Manufacture of substances
ERC2 Formulation of preparations
ERC6a Industrial use resulting in manufacture of another substance (use of intermediates)
ERC6b Industrial use of reactive processing aids
2. Contributing scenarios: Operational conditions and risk management measures
2.1 Contributing scenario controlling worker exposure for: PROC1, PROC2, PROC3, PROC4, PROC5, PROC8a,
PROC8b, PROC9, PROC15
SAFETY DATA SHEET – Annex
according to Regulation (EC) No. 1907/2006
Catalogue No. D45399
Product name Imidazole, ULTROL® Grade
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 19 of 24
Product characteristics
Concentration of the Substance in
Mixture/Article
Covers the percentage of the substance in the product up to
100 %.
Physical Form (at time of use) Solid, low dustiness
Frequency and duration of use
Frequency of use 8 hours/day
Frequency of use 5 days/week
Other operational conditions affecting workers exposure
Outdoor / Indoor Indoor without local exhaust ventilation (LEV)
Organisational measures to prevent /limit releases, dispersion and exposure
Covers daily exposures up to 8 hours.
Conditions and measures related to personal protection, hygiene and health evaluation
Wear chemically resistant gloves (tested to EN374) in combination with ‘basic’ employee training. Use
suitable eye protection. Wear suitable coveralls to prevent exposure to the skin.
Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice Avoid contact with the skin and the eyes. Do not inhale
substance/mixture.
2.2 Contributing scenario controlling worker exposure for: PROC10
Product characteristics
Concentration of the Substance in
Mixture/Article
Covers the percentage of the substance in the product up to
10 %.
Physical Form (at time of use) Solid, low dustiness
Frequency and duration of use
Frequency of use 8 hours/day
Frequency of use 5 days/week
Other operational conditions affecting workers exposure
Outdoor / Indoor Indoor without local exhaust ventilation (LEV)
Organisational measures to prevent /limit releases, dispersion and exposure
Covers daily exposures up to 8 hours.
SAFETY DATA SHEET – Annex
according to Regulation (EC) No. 1907/2006
Catalogue No. D45399
Product name Imidazole, ULTROL® Grade
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 20 of 24
Conditions and measures related to personal protection, hygiene and health evaluation
Wear chemically resistant gloves (tested to EN374) in combination with ‘basic’ employee training. Use
suitable eye protection. Wear suitable coveralls to prevent exposure to the skin.
Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice Avoid contact with the skin and the eyes. Do not inhale
substance/mixture.
3. Exposure estimation and reference to its source
Environment
A chemical safety assessment was performed according REACH Article 14(3), Annex I, sections 3
(Environmental Hazard Assessment) and 4 (PBT/vPvB Assessment). As no hazard was identified, an exposure
assessment and risk characterisation is not necessary (REACH Annex I section 5.0).
SAFETY DATA SHEET – Annex
according to Regulation (EC) No. 1907/2006
Catalogue No. D45399
Product name Imidazole, ULTROL® Grade
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 21 of 24
Workers
CS Use descriptor Exposure duration, route, effect RCR Exposure Assessment Method
2.1 PROC1 longterm, dermal, systemic 0,02 ECETOC TRA, modified
longterm, inhalative, systemic < 0,01 ECETOC TRA, modified
longterm, combined, systemic 0,02
2.1 PROC2 longterm, dermal, systemic 0,09 ECETOC TRA, modified
longterm, inhalative, systemic < 0,01 ECETOC TRA, modified
longterm, combined, systemic 0,09
2.1 PROC3 longterm, dermal, systemic 0,02 ECETOC TRA, modified
longterm, inhalative, systemic 0,01 ECETOC TRA, modified
longterm, combined, systemic 0,03
2.1 PROC4 longterm, dermal, systemic 0,46 ECETOC TRA, modified
longterm, inhalative, systemic 0,05 ECETOC TRA, modified
longterm, combined, systemic 0,50
2.1 PROC5 longterm, dermal, systemic 0,46 ECETOC TRA, modified
longterm, inhalative, systemic 0,09 ECETOC TRA, modified
longterm, combined, systemic 0,55
2.1 PROC8a longterm, dermal, systemic 0,91 ECETOC TRA, modified
longterm, inhalative, systemic 0,05 ECETOC TRA, modified
longterm, combined, systemic 0,96
2.1 PROC8b longterm, dermal, systemic 0,46 ECETOC TRA, modified
longterm, inhalative, systemic 0,05 ECETOC TRA, modified
longterm, combined, systemic 0,50
2.1 PROC9 longterm, dermal, systemic 0,46 ECETOC TRA, modified
longterm, inhalative, systemic 0,01 ECETOC TRA, modified
longterm, combined, systemic 0,47
2.1 PROC15 longterm, dermal, systemic 0,02 ECETOC TRA, modified
longterm, inhalative, systemic 0,01 ECETOC TRA, modified
longterm, combined, systemic 0,03
2.2 PROC10 longterm, dermal, systemic 0,18 ECETOC TRA, modified
longterm, inhalative, systemic 0,27 ECETOC TRA, modified
longterm, combined, systemic 0,45
The default parameters and -efficiencies of the applied exposure assessment model were used for
the calculation (unless stated differently).
For (other) local effects risk management measures are based on qualitative risk characterisation.
SAFETY DATA SHEET – Annex
according to Regulation (EC) No. 1907/2006
Catalogue No. D45399
Product name Imidazole, ULTROL® Grade
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 22 of 24
4. Guidance to Downstream User to evaluate whether he works inside the boundaries set by the Exposure
Scenario
Please refer to the following documents: ECHA Guidance on information requirements and chemical
safety assessment Chapter R.12: Use descriptor system; ECHA Guidance for downstream users;
ECHA Guidance on information requirements and chemical safety assessment Part D: Exposure
Scenario Building, Part E: Risk Characterisation and Part G: Extending the SDS; VCI/Cefic REACH
Practical Guides on Exposure Assessment and Communications in the Supply Chain; CEFIC
Guidance Specific Environmental Release Categories (SPERCs).
For scaling of worker exposure assessments performed with ECETOC TRA, please consult the Merck
tool ScIDeEx® at www.merckmillipore.com/scideex.
SAFETY DATA SHEET – Annex
according to Regulation (EC) No. 1907/2006
Catalogue No. D45399
Product name Imidazole, ULTROL® Grade
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 23 of 24
EXPOSURE SCENARIO 2 (Professional use)
1. Professional use Reagent for development and research)
Sectors of end-use
SU 22 Professional uses: Public domain (administration, education, entertainment, services,
craftsmen)
Chemical product category
PC21 Laboratory chemicals
Process categories
PROC15 Use as laboratory reagent
Environmental Release Categories
ERC2 Formulation of preparations
ERC6a Industrial use resulting in manufacture of another substance (use of intermediates)
ERC6b Industrial use of reactive processing aids
2. Contributing scenarios: Operational conditions and risk management measures
2.1 Contributing scenario controlling worker exposure for: PROC15
Product characteristics
Concentration of the Substance in
Mixture/Article
Covers the percentage of the substance in the product up to
100 %.
Physical Form (at time of use) Solid, low dustiness
Frequency and duration of use
Frequency of use 8 hours/day
Frequency of use 5 days/week
Other operational conditions affecting workers exposure
Outdoor / Indoor Indoor without local exhaust ventilation (LEV)
Organisational measures to prevent /limit releases, dispersion and exposure
Covers daily exposures up to 8 hours.
Conditions and measures related to personal protection, hygiene and health evaluation
Wear chemically resistant gloves (tested to EN374) in combination with ‘basic’ employee training. Use
SAFETY DATA SHEET – Annex
according to Regulation (EC) No. 1907/2006
Catalogue No. D45399
Product name Imidazole, ULTROL® Grade
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 24 of 24
suitable eye protection. Wear suitable coveralls to prevent exposure to the skin.
Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice Avoid contact with the skin and the eyes. Do not inhale
substance/mixture.
3. Exposure estimation and reference to its source
Environment
A chemical safety assessment was performed according REACH Article 14(3), Annex I, sections 3
(Environmental Hazard Assessment) and 4 (PBT/vPvB Assessment). As no hazard was identified, an exposure
assessment and risk characterisation is not necessary (REACH Annex I section 5.0).
Workers
CS Use descriptor Exposure duration, route, effect RCR Exposure Assessment Method
2.1 PROC15 longterm, dermal, systemic 0,02 ECETOC TRA, modified
longterm, inhalative, systemic 0,01 ECETOC TRA, modified
longterm, combined, systemic 0,03
The default parameters and -efficiencies of the applied exposure assessment model were used for
the calculation (unless stated differently).
For (other) local effects risk management measures are based on qualitative risk characterisation.
4. Guidance to Downstream User to evaluate whether he works inside the boundaries set by the Exposure
Scenario
Please refer to the following documents: ECHA Guidance on information requirements and chemical
safety assessment Chapter R.12: Use descriptor system; ECHA Guidance for downstream users;
ECHA Guidance on information requirements and chemical safety assessment Part D: Exposure
Scenario Building, Part E: Risk Characterisation and Part G: Extending the SDS; VCI/Cefic REACH
Practical Guides on Exposure Assessment and Communications in the Supply Chain; CEFIC
Guidance Specific Environmental Release Categories (SPERCs).
For scaling of worker exposure assessments performed with ECETOC TRA, please consult the Merck
tool ScIDeEx® at www.merckmillipore.com/scideex.
Citraconic Anhydride
2,5-Furandione, 3-methyl-
Liquid.
CHEMTREC: 800.424.9300Outside US: 703.527.3887
SAFETY DATA SHEET
GHS product identifier
Other means of identification
Product type
Emergency telephone number (with hours of operation)
Section 1. Identification:
:
:
Chemical name : citraconic anhydride
Supplier's details : Thermo Fisher Scientific Pierce BiotechnologyP.O. Box 117Rockford, IL 61105United States815.968.0747 or800.874.37237 AM - 5 PM Central Time (GMT -06:00)
Citraconic Anhydride
Relevant identified uses of the substance or mixture and uses advised against
Not applicable.
Product code
SDS #
CAS #
Chemical formula
:
:
:
:
:
0020907 0020907B 1871270 1900417 NCI2090
2139
C5-H4-O3
616-02-4
Section 2. Hazards identification
ACUTE TOXICITY (dermal) - Category 3SKIN CORROSION/IRRITATION - Category 1BSERIOUS EYE DAMAGE/ EYE IRRITATION - Category 2ARESPIRATORY SENSITIZATION - Category 1SKIN SENSITIZATION - Category 1SPECIFIC TARGET ORGAN TOXICITY (SINGLE EXPOSURE) (Respiratory tract irritation) - Category 3
Classification of the substance or mixture
:
Signal word : Danger
Hazard statements : Toxic in contact with skin.Causes severe skin burns and eye damage.May cause allergy or asthma symptoms or breathing difficulties if inhaled.May cause an allergic skin reaction.May cause respiratory irritation.
Hazard pictograms :
Precautionary statements
Prevention : Wear protective gloves. Wear eye or face protection. Wear protective clothing. In case of inadequate ventilation wear respiratory protection. Use only outdoors or in a well-ventilated area. Avoid breathing vapor. Wash hands thoroughly after handling.Contaminated work clothing should not be allowed out of the workplace.
GHS label elements
OSHA/HCS status : This material is considered hazardous by the OSHA Hazard Communication Standard (29 CFR 1910.1200).
Date of issue/Date of revision : 6/25/2014. Date of previous issue : No previous validation. Version : 1 1/11
Citraconic Anhydride
Section 2. Hazards identificationResponse : IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for
breathing. Immediately call a POISON CENTER or physician. If experiencing respiratory symptoms: Call a POISON CENTER or physician. IF SWALLOWED:Immediately call a POISON CENTER or physician. Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower. Wash contaminated clothing before reuse. Immediately call a POISON CENTER or physician. IF ON SKIN: Wash with plenty of soap and water. Call a POISON CENTER or physician if you feel unwell. If skin irritation or rash occurs: Get medical attention. IF IN EYES: Rinse cautiously with water for several minutes.Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or physician. If eye irritation persists: Get medical attention.
Storage : Store locked up.
Disposal : Dispose of contents and container in accordance with all local, regional, national and international regulations.
Hazards not otherwise classified
: None known.
Section 3. Composition/information on ingredients
citraconic anhydride 98 - 100 616-02-4
Ingredient name CAS number%
There are no additional ingredients present which, within the current knowledge of the supplier and in the concentrations applicable, are classified as hazardous to health or the environment and hence require reporting in this section.
Chemical name : citraconic anhydride
Other means of identification
: 2,5-Furandione, 3-methyl-
CAS number : 616-02-4
Substance/mixture
CAS number/other identifiers
:
Occupational exposure limits, if available, are listed in Section 8.
Substance
Any concentration shown as a range is to protect confidentiality or is due to batch variation.
Get medical attention immediately. Call a poison center or physician. Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Continue to rinse for at least 10 minutes. Chemical burns must be treated promptly by a physician.
Get medical attention immediately. Call a poison center or physician. Wash with plenty of soap and water. Remove contaminated clothing and shoes. Wash contaminated clothing thoroughly with water before removing it, or wear gloves. Continue to rinse for at least 10 minutes. Chemical burns must be treated promptly by a physician. In the event of any complaints or symptoms, avoid further exposure. Wash clothing before reuse.Clean shoes thoroughly before reuse.
Get medical attention immediately. Call a poison center or physician. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If it is suspected that fumes are still present, the rescuer should wear an appropriate mask or self-contained breathing apparatus. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway.Loosen tight clothing such as a collar, tie, belt or waistband. In the event of any complaints or symptoms, avoid further exposure.
Section 4. First aid measures
Eye contact
Skin contact
Inhalation
:
:
:
Description of necessary first aid measures
Date of issue/Date of revision : 6/25/2014. Date of previous issue : No previous validation. Version : 1 2/11
Citraconic Anhydride
Section 4. First aid measuresGet medical attention immediately. Call a poison center or physician. Wash out mouth with water. Remove dentures if any. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Stop if the exposed person feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do so by medical personnel. If vomiting occurs, the head should be kept low so that vomit does not enter the lungs. Chemical burns must be treated promptly by a physician.Never give anything by mouth to an unconscious person. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway.Loosen tight clothing such as a collar, tie, belt or waistband.
Ingestion :
Protection of first-aiders : No action shall be taken involving any personal risk or without suitable training. If it is suspected that fumes are still present, the rescuer should wear an appropriate mask or self-contained breathing apparatus. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. Wash contaminated clothing thoroughly with water before removing it, or wear gloves.
Notes to physician : Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled.
Specific treatments : No specific treatment.
Most important symptoms/effects, acute and delayed
Inhalation : May cause respiratory irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled.
May cause burns to mouth, throat and stomach.:Ingestion
Skin contact : Causes severe burns. Toxic in contact with skin. May cause an allergic skin reaction.
Causes serious eye damage.:Eye contact
Over-exposure signs/symptoms
Skin contact
Ingestion
Inhalation Adverse symptoms may include the following:respiratory tract irritationcoughingwheezing and breathing difficultiesasthma
Adverse symptoms may include the following:stomach pains
Adverse symptoms may include the following:pain or irritationrednessblistering may occur
:
:
:
Eye contact : Adverse symptoms may include the following:painwateringredness
Potential acute health effects
See toxicological information (Section 11)
Indication of immediate medical attention and special treatment needed, if necessary
Section 5. Fire-fighting measures
Specific hazards arising from the chemical
In a fire or if heated, a pressure increase will occur and the container may burst.
Use an extinguishing agent suitable for the surrounding fire.
Extinguishing media
:
None known.
Suitable extinguishing media
:
Unsuitable extinguishing media
:
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Citraconic Anhydride
Section 5. Fire-fighting measures
Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training.
Hazardous thermal decomposition products
Decomposition products may include the following materials:carbon dioxidecarbon monoxide
Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode.
Special protective equipment for fire-fighters
:
:
Special protective actions for fire-fighters
:
Section 6. Accidental release measures
Environmental precautions
Personal precautions, protective equipment and emergency procedures
Stop leak if without risk. Move containers from spill area. Approach release from upwind.Prevent entry into sewers, water courses, basements or confined areas. Wash spillages into an effluent treatment plant or proceed as follows. Contain and collect spillage with non-combustible, absorbent material e.g. sand, earth, vermiculite or diatomaceous earth and place in container for disposal according to local regulations (see Section 13).Dispose of via a licensed waste disposal contractor. Contaminated absorbent material may pose the same hazard as the spilled product. Note: see Section 1 for emergency contact information and Section 13 for waste disposal.
:
: No action shall be taken involving any personal risk or without suitable training.Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilled material. Do not breathe vapor or mist.Provide adequate ventilation. Wear appropriate respirator when ventilation is inadequate.Put on appropriate personal protective equipment.
Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air).
Large spill :
Stop leak if without risk. Move containers from spill area. Dilute with water and mop up if water-soluble. Alternatively, or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Dispose of via a licensed waste disposal contractor.
Small spill :
Methods and materials for containment and cleaning up
For non-emergency personnel
For emergency responders : If specialised clothing is required to deal with the spillage, take note of any information in Section 8 on suitable and unsuitable materials. See also the information in "For non-emergency personnel".
Section 7. Handling and storage
Advice on general occupational hygiene
Conditions for safe storage,including any incompatibilities
Eating, drinking and smoking should be prohibited in areas where this material is handled,stored and processed. Workers should wash hands and face before eating, drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures.
Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Store locked up. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabeled containers. Use appropriate containment to avoid environmental contamination.
:
:
Protective measures Put on appropriate personal protective equipment (see Section 8). Persons with a history of skin sensitization problems or asthma, allergies or chronic or recurrent respiratory disease should not be employed in any process in which this product is used. Do not get in eyes or on skin or clothing. Do not breathe vapor or mist. Do not ingest. Use only with adequate ventilation. Wear appropriate respirator when ventilation is inadequate.Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use. Empty containers retain product residue and can be hazardous. Do not reuse container.
:
Precautions for safe handling
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Citraconic Anhydride
None.
Section 8. Exposure controls/personal protection
Hand protection
Use a properly fitted, air-purifying or air-fed respirator complying with an approved standard if a risk assessment indicates this is necessary. Respirator selection must be based on known or anticipated exposure levels, the hazards of the product and the safe working limits of the selected respirator.
Chemical-resistant, impervious gloves complying with an approved standard should be worn at all times when handling chemical products if a risk assessment indicates this is necessary. Considering the parameters specified by the glove manufacturer, check during use that the gloves are still retaining their protective properties. It should be noted that the time to breakthrough for any glove material may be different for different glove manufacturers. In the case of mixtures, consisting of several substances, the protection time of the gloves cannot be accurately estimated.
Safety eyewear complying with an approved standard should be used when a risk assessment indicates this is necessary to avoid exposure to liquid splashes, mists,gases or dusts. If contact is possible, the following protection should be worn, unless the assessment indicates a higher degree of protection: chemical splash goggles and/or face shield. If inhalation hazards exist, a full-face respirator may be required instead.
Eye/face protection
Respiratory protection :
:
:
Body protection Personal protective equipment for the body should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product.
:
Environmental exposure controls
: Emissions from ventilation or work process equipment should be checked to ensure they comply with the requirements of environmental protection legislation. In some cases,fume scrubbers, filters or engineering modifications to the process equipment will be necessary to reduce emissions to acceptable levels.
Appropriate engineering controls
: Use only with adequate ventilation. If user operations generate dust, fumes, gas, vapor or mist, use process enclosures, local exhaust ventilation or other engineering controls to keep worker exposure to airborne contaminants below any recommended or statutory limits.
Wash hands, forearms and face thoroughly after handling chemical products, before eating, smoking and using the lavatory and at the end of the working period. Appropriate techniques should be used to remove potentially contaminated clothing. Contaminated work clothing should not be allowed out of the workplace. Wash contaminated clothing before reusing. Ensure that eyewash stations and safety showers are close to the workstation location.
Hygiene measures :
Control parameters
Individual protection measures
Occupational exposure limits
Skin protection
Other skin protection : Appropriate footwear and any additional skin protection measures should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product.
Section 9. Physical and chemical properties
Physical state
Melting point
Liquid. [Clear sparkling liquid.]
7 to 8°C (44.6 to 46.4°F)
Not available.Odor
pH
Colorless. Yellow. [Light]Color
Flash point Closed cup: 100.85°C (213.5°F)
Not available.
Not available.Odor threshold
:
:
:
:
:
:
:
Appearance
Boiling point : 213 to 214°C (415.4 to 417.2°F)
Burning rate Not applicable.:
Burning time : Not applicable.
Date of issue/Date of revision : 6/25/2014. Date of previous issue : No previous validation. Version : 1 5/11
Citraconic Anhydride
Section 9. Physical and chemical properties
Vapor pressure
Relative density
Vapor density
Solubility
1.245
4 [Air = 1]
0.13 kPa (1 mm Hg) [room temperature]
Partially soluble in the following materials: methanol, diethyl ether and acetone.
Evaporation rate Not available.
Auto-ignition temperature Not available.
Not available.
Viscosity Not available.
Partition coefficient: n-octanol/water
:
:
:
:
:
:
:
:
Flammability (solid, gas) : Not available.
Lower and upper explosive (flammable) limits
: Not available.
SADT Not available.:
Decomposition temperature : Not available.
Solubility in water : Not available.
Section 10. Stability and reactivity
Hazardous decomposition products
Conditions to avoid No specific data.
Under normal conditions of storage and use, hazardous decomposition products should not be produced.
The product is stable.Chemical stability
No specific data.
:
:
:
Incompatible materials :
Possibility of hazardous reactions
: Under normal conditions of storage and use, hazardous reactions will not occur.
Reactivity : No specific test data related to reactivity available for this product or its ingredients.
Section 11. Toxicological information
Acute toxicity
citraconic anhydride LD50 Dermal Rabbit 218 mg/kg -LD50 Oral Rat 2600 mg/kg -
Product/ingredient name Result Species Dose Exposure
Carcinogenicity
Not available.
Mutagenicity
Not available.
Reproductive toxicity
Irritation/Corrosion
Not available.
Sensitization
Not available.
Information on toxicological effects
Classification
citraconic anhydride None. - -
Product/ingredient name NTPIARCOSHA
Date of issue/Date of revision : 6/25/2014. Date of previous issue : No previous validation. Version : 1 6/11
Citraconic Anhydride
Section 11. Toxicological information
Not available.
Conclusion/Summary : Exposure can cause coughing, chest pains and difficulty in breathing. Exposure can cause stomach pains, vomiting and diarrhea.
Teratogenicity
Not available.
Not available.
Information on the likely routes of exposure
Inhalation : May cause respiratory irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled.
May cause burns to mouth, throat and stomach.:Ingestion
Skin contact : Causes severe burns. Toxic in contact with skin. May cause an allergic skin reaction.
Causes serious eye damage.:Eye contact
Symptoms related to the physical, chemical and toxicological characteristics
Skin contact
Ingestion
Inhalation Adverse symptoms may include the following:respiratory tract irritationcoughingwheezing and breathing difficultiesasthma
Adverse symptoms may include the following:stomach pains
Adverse symptoms may include the following:pain or irritationrednessblistering may occur
:
:
:
Eye contact : Adverse symptoms may include the following:painwateringredness
Potential chronic health effects
Delayed and immediate effects and also chronic effects from short and long term exposure
Specific target organ toxicity (single exposure)
Specific target organ toxicity (repeated exposure)
citraconic anhydride Category 3 Not applicable. Respiratory tract irritation
Name Category
Not available.
Aspiration hazard
Not available.
Route of exposure
Target organs
: Routes of entry anticipated: Oral, Dermal, Inhalation.
Potential acute health effects
Potential immediate effects
: Not available.
Short term exposure
Potential delayed effects : Not available.
Potential immediate effects
: Not available.
Long term exposure
Potential delayed effects : Not available.
Date of issue/Date of revision : 6/25/2014. Date of previous issue : No previous validation. Version : 1 7/11
Citraconic Anhydride
Section 11. Toxicological informationOnce sensitized, a severe allergic reaction may occur when subsequently exposed to very low levels.
General :
No known significant effects or critical hazards.Carcinogenicity :
No known significant effects or critical hazards.Mutagenicity :
No known significant effects or critical hazards.Teratogenicity :
Developmental effects : No known significant effects or critical hazards.
Fertility effects : No known significant effects or critical hazards.
Numerical measures of toxicity
Not available.
Acute toxicity estimates
Section 12. Ecological information
Bioaccumulative potential
Other adverse effects : No known significant effects or critical hazards.
Not available.
Toxicity
Not available.
Persistence and degradability
Soil/water partition coefficient (KOC)
: Not available.
Mobility in soil
Not available.
Section 13. Disposal considerationsThe generation of waste should be avoided or minimized wherever possible. Disposal of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Waste should not be disposed of untreated to the sewer unless fully compliant with the requirements of all authorities with jurisdiction.Waste packaging should be recycled. Incineration or landfill should only be considered when recycling is not feasible. This material and its container must be disposed of in a safe way. Care should be taken when handling emptied containers that have not been cleaned or rinsed out. Empty containers or liners may retain some product residues.Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers.
:Disposal methods
Section 14. Transport information
Toxic, liquids, organic, n.o.s.(citraconic anhydride)
Toxic liquid, organic, n.o.s. (citraconic anhydride)
UN2810UN2810
DOT Classification IATA
UN number
UN proper shipping name
Date of issue/Date of revision : 6/25/2014. Date of previous issue : No previous validation. Version : 1 8/11
Citraconic Anhydride
Section 14. Transport information6.1
III
6.1
III
Packaging instructionPassenger aircraftQuantity limitation: 60 L
Cargo aircraftQuantity limitation: 220 L
-
Transport hazard class(es)
Packing group
Additional information
Environmental hazards
Special precautions for user
Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
No. No.
Transport within user’s premises: always transport in closed containers that are upright and secure. Ensure that persons transporting the product know what to do in the event of an accident or spillage.
: Not available.
:
Section 15. Regulatory informationU.S. Federal regulations
This material is not listed.Massachusetts
:
:
Clean Air Act Section 112(b) Hazardous Air Pollutants (HAPs)
: Not listed
Clean Air Act Section 602 Class I Substances
: Not listed
Clean Air Act Section 602 Class II Substances
: Not listed
DEA List I Chemicals (Precursor Chemicals)
: Not listed
DEA List II Chemicals (Essential Chemicals)
: Not listed
State regulations
TSCA 8(a) CDR Exempt/Partial exemption: Not determined
United States inventory (TSCA 8b): This material is listed or exempted.
SARA 302/304
SARA 304 RQ : Not applicable.
No products were found.
Composition/information on ingredients
SARA 311/312
Classification : Immediate (acute) health hazard
citraconic anhydride 98 - 100 No. No. No. Yes. No.
Name % Fire hazard
Sudden release of pressure
Reactive Immediate (acute)health hazard
Delayed (chronic)health hazard
Composition/information on ingredients
Date of issue/Date of revision : 6/25/2014. Date of previous issue : No previous validation. Version : 1 9/11
Citraconic Anhydride
Section 15. Regulatory informationNew York : This material is not listed.
New Jersey : This material is not listed.
Pennsylvania : This material is not listed.
Canada inventory : This material is listed or exempted.
Australia inventory (AICS): Not determined.China inventory (IECSC): Not determined.Japan inventory: This material is listed or exempted.Korea inventory: Not determined.Malaysia Inventory (EHS Register): Not determined.New Zealand Inventory of Chemicals (NZIoC): Not determined.Philippines inventory (PICCS): This material is listed or exempted.Taiwan inventory (CSNN): Not determined.
International regulations
International lists :
Chemical Weapons Convention List Schedule I Chemicals
: Not listed
Chemical Weapons Convention List Schedule II Chemicals
: Not listed
Chemical Weapons Convention List Schedule III Chemicals
: Not listed
Section 16. Other information
6/25/2014.
History
Date of printing
Date of issue/Date of revision
:
: 6/25/2014.
Hazardous Material Information System (U.S.A.)
2
1
0
0
1
2
National Fire Protection Association (U.S.A.)
Health
Special
Instability/Reactivity
Flammability
Health
Flammability
Caution: HMIS® ratings are based on a 0-4 rating scale, with 0 representing minimal hazards or risks, and 4 representing significant hazards or risks Although HMIS® ratings are not required on SDSs under 29 CFR 1910.1200, the preparer may choose to provide them. HMIS® ratings are to be used with a fully implemented HMIS® program. HMIS® is a registered mark of the National Paint & Coatings Association (NPCA). HMIS® materials may be purchased exclusively from J. J. Keller (800) 327-6868.
The customer is responsible for determining the PPE code for this material.
Reprinted with permission from NFPA 704-2001, Identification of the Hazards of Materials for Emergency Response Copyright ©1997, National Fire Protection Association, Quincy, MA 02269. This reprinted material is not the complete and official position of the National Fire Protection Association, on the referenced subject which is represented only by the standard in its entirety.
Copyright ©2001, National Fire Protection Association, Quincy, MA 02269. This warning system is intended to be interpreted and applied only by properly trained individuals to identify fire, health and reactivity hazards of chemicals. The user is referred to certain limited number of chemicals with recommended classifications in NFPA 49 and NFPA 325, which would be used as a guideline only. Whether the chemicals are classified by NFPA or not,anyone using the 704 systems to classify chemicals does so at their own risk.
Physical hazards
Chronic Health Hazard
Date of issue/Date of revision : 6/25/2014. Date of previous issue : No previous validation. Version : 1 10/11
Citraconic Anhydride
Section 16. Other information
Version
To the best of our knowledge, the information contained herein is accurate. However, neither the above-named supplier, nor any of its subsidiaries, assumes any liability whatsoever for the accuracy or completeness of the information contained herein.Final determination of suitability of any material is the sole responsibility of the user. All materials may present unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot guarantee that these are the only hazards that exist.
Notice to reader
Date of previous issue
:
:
Indicates information that has changed from previously issued version.
References : Not available.
Key to abbreviations : ATE = Acute Toxicity EstimateBCF = Bioconcentration FactorGHS = Globally Harmonized System of Classification and Labelling of ChemicalsIATA = International Air Transport AssociationIBC = Intermediate Bulk ContainerIMDG = International Maritime Dangerous GoodsLogPow = logarithm of the octanol/water partition coefficientMARPOL 73/78 = International Convention for the Prevention of Pollution From Ships,1973 as modified by the Protocol of 1978. ("Marpol" = marine pollution)UN = United Nations
No previous validation.
1
SDS SpecialistPrepared by :
Date of issue/Date of revision : 6/25/2014. Date of previous issue : No previous validation. Version : 1 11/11
Sigma - T3568 Page 1 of 7
SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006 Version 6.1 Revision Date 02.01.2017
Print Date 18.06.2018 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA
SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1 Product identifiers Product name : TrypZean®, bovine
Product Number : T3568 Brand : Sigma Index-No. : 647-010-00-7 REACH No. : A registration number is not available for this substance as the substance
or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.
CAS-No. : 9002-07-7
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances
1.3 Details of the supplier of the safety data sheet
Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA
1.4 Emergency telephone number
Emergency Phone # : +91 98802 05043
SECTION 2: Hazards identification
2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 Eye irritation (Category 2), H319 Specific target organ toxicity - single exposure (Category 3), H335 Skin irritation (Category 2), H315 Respiratory sensitisation (Category 1), H334
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008 Pictogram
Signal word Danger Hazard statement(s) H315 Causes skin irritation. H319 Causes serious eye irritation. H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Sigma - T3568 Page 2 of 7
H335 May cause respiratory irritation. Precautionary statement(s) P261 Avoid breathing dust. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing. P342 + P311 If experiencing respiratory symptoms: Call a POISON CENTER/doctor. Supplemental Hazard Statements
none
2.3 Other hazards - none
SECTION 3: Composition/information on ingredients
3.1 Substances Synonyms : Trypsinbovine
CAS-No. : 9002-07-7 EC-No. : 232-650-8 Index-No. : 647-010-00-7 Hazardous ingredients according to Regulation (EC) No 1272/2008
Component Classification Concentration
Trypsin
CAS-No. EC-No. Index-No.
9002-07-7 232-650-8 647-010-00-7
Skin Irrit. 2; Eye Irrit. 2; Resp. Sens. 1; STOT SE 3; H315, H319, H334, H335
<= 100 %
For the full text of the H-Statements mentioned in this Section, see Section 16.
SECTION 4: First aid measures
4.1 Description of first aid measures
General advice Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact Wash off with soap and plenty of water. Consult a physician.
In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed No data available
SECTION 5: Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Sigma - T3568 Page 3 of 7
5.2 Special hazards arising from the substance or mixture Nature of decomposition products not known.
5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information No data available
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
6.4 Reference to other sections For disposal see section 13.
SECTION 7: Handling and storage
7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Recommended storage temperature -20 °C
Keep in a dry place. Storage class (TRGS 510): Combustible Solids
7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
8.2 Exposure controls
Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
Personal protective equipment
Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Sigma - T3568 Page 4 of 7
Full contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle r (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure Do not let product enter drains.
SECTION 9: Physical and chemical properties
9.1 Information on basic physical and chemical properties
a) Appearance Form: powder, lyophilized
b) Odour No data available
c) Odour Threshold No data available
d) pH No data available
e) Melting point/freezing point
No data available
f) Initial boiling point and boiling range
No data available
g) Flash point No data available
h) Evaporation rate No data available
i) Flammability (solid, gas) No data available
j) Upper/lower flammability or explosive limits
No data available
k) Vapour pressure No data available
l) Vapour density No data available
m) Relative density No data available
n) Water solubility No data available
o) Partition coefficient: n-octanol/water
No data available
p) Auto-ignition No data available
Sigma - T3568 Page 5 of 7
temperature
q) Decomposition temperature
No data available
r) Viscosity No data available
s) Explosive properties No data available
t) Oxidizing properties No data available
9.2 Other safety information No data available
SECTION 10: Stability and reactivity
10.1 Reactivity No data available
10.2 Chemical stability Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions No data available
10.4 Conditions to avoid No data available
10.5 Incompatible materials Strong oxidizing agents
10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Nature of decomposition products not known. Other decomposition products - No data available In the event of fire: see section 5
SECTION 11: Toxicological information
11.1 Information on toxicological effects
Acute toxicity LD50 Oral - Rat - > 5,000 mg/kg(Trypsin)
Skin corrosion/irritation No data available(Trypsin)
Serious eye damage/eye irritation No data available(Trypsin)
Respiratory or skin sensitisation No data available(Trypsin)
Germ cell mutagenicity No data available(Trypsin)
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
No data available(Trypsin)
Specific target organ toxicity - single exposure No data available(Trypsin)
Sigma - T3568 Page 6 of 7
Specific target organ toxicity - repeated exposure No data available
Aspiration hazard No data available(Trypsin)
Additional Information RTECS: YN5075000 To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Trypsin) Liver - Irregularities - Based on Human Evidence(Trypsin)
SECTION 12: Ecological information
12.1 Toxicity No data available
12.2 Persistence and degradability No data available
12.3 Bioaccumulative potential No data available
12.4 Mobility in soil No data available(Trypsin)
12.5 Results of PBT and vPvB assessment PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Other adverse effects No data available
SECTION 13: Disposal considerations
13.1 Waste treatment methods
Product Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chem scrubber.
Contaminated packaging Dispose of as unused product.
SECTION 14: Transport information
14.1 UN number ADR/RID: - IMDG: - IATA: -
14.2 UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods
14.3 Transport hazard class(es) ADR/RID: - IMDG: - IATA: -
14.4 Packaging group ADR/RID: - IMDG: - IATA: -
14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user No data available
Sigma - T3568 Page 7 of 7
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out
SECTION 16: Other information
Full text of H-Statements referred to under sections 2 and 3.
H315 Causes skin irritation. H319 Causes serious eye irritation. H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. H335 May cause respiratory irritation.
Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Revision Date 14.08.2017 Version 1.1
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 18
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 100997
Product name 1-Propanol for analysis EMSURE® ACS,Reag. Ph Eur
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.
CAS-No. 71-23-8
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Reagent for analysis, Chemical production
For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * 8th Floor, Godrej One,
Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079
India * Tel: 0091 22 6210 9000
Responsible Department Quality Assurance * Merck Life Science Private Limited *
e-mail: [email protected] *
Tel : +91-2267863131-6
1.4 Emergency telephone
number
Please contact the regional company representation in your country.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100997
Product name 1-Propanol for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 18
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
Classification (REGULATION (EC) No 1272/2008)
Flammable liquid, Category 2, H225
Serious eye damage, Category 1, H318
Specific target organ toxicity - single exposure, Category 3, Central nervous system, H336
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Hazard pictograms
Signal word
Danger
Hazard statements
H225 Highly flammable liquid and vapour.
H318 Causes serious eye damage.
H336 May cause drowsiness or dizziness.
Precautionary statements
Prevention
P210 Keep away from heat/sparks/open flames/hot surfaces. No smoking.
P240 Ground/bond container and receiving equipment.
P280 Wear eye protection.
Response
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
P313 Get medical advice/ attention.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100997
Product name 1-Propanol for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 18
Storage
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
Reduced labelling (≤125 ml)
Hazard pictograms
Signal word
Danger
Hazard statements
H318 Causes serious eye damage.
Precautionary statements
P280 Wear eye protection.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing.
P313 Get medical advice/ attention.
CAS-No. 71-23-8
2.3 Other hazards
None known.
SECTION 3. Composition/information on ingredients
3.1 Substance
Formula CH₃CH₂CH₂OH C₃H₈O (Hill)
EC-No. 200-746-9
Molar mass 60.1 g/mol
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100997
Product name 1-Propanol for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 4 of 18
Hazardous components (REGULATION (EC) No 1272/2008)
Chemical name (Concentration)
CAS-No. Registration number Classification
1-Propanol (<= 100 % )
Substance does not meet the criteria for PBT or vPvB according to Regulation (EC) No 1907/2006, Annex XIII.
71-23-8 *) Flammable liquid, Category 2, H225
Serious eye damage, Category 1, H318
Specific target organ toxicity - single exposure, Category 3, H336
*) A registration number is not available for this substance as the substance or its use are exempted from registration according to Article
2 REACH Regulation (EC) No 1907/2006, the annual tonnage does not require a registration or the registration is envisaged for a later
registration deadline.
For the full text of the H-Statements mentioned in this Section, see Section 16.
3.2 Mixture
Not applicable
SECTION 4. First aid measures
4.1 Description of first aid measures
After inhalation: fresh air. Call in physician.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower.
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove
contact lenses.
After swallowing: caution if victim vomits. Risk of aspiration! Keep airways free. Call a physician
immediately. Subsequently administer: activated charcoal (20 - 40 g in 10% slurry).
4.2 Most important symptoms and effects, both acute and delayed
Irritation and corrosion, Cough, respiratory paralysis, Shortness of breath, Drowsiness,
Unconsciousness, narcosis, inebriation, Vertigo, somnolence, Headache, Coma
Risk of serious damage to eyes.
4.3 Indication of any immediate medical attention and special treatment needed
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100997
Product name 1-Propanol for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 5 of 18
Laxative: Sodium sulfate (1 tablespoon/1/4 l water).
SECTION 5. Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Foam, Carbon dioxide (CO2), Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Combustible.
Vapours are heavier than air and may spread along floors.
Forms explosive mixtures with air at ambient temperatures.
Pay attention to flashback.
Development of hazardous combustion gases or vapours possible in the event of fire.
5.3 Advice for firefighters
Special protective equipment for firefighters
In the event of fire, wear self-contained breathing apparatus.
Further information
Remove container from danger zone and cool with water. Prevent fire extinguishing water from
contaminating surface water or the ground water system.
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapours, aerosols. Avoid substance
contact. Ensure adequate ventilation. Keep away from heat and sources of ignition. Evacuate the
danger area, observe emergency procedures, consult an expert.
Advice for emergency responders:
Protective equipment see section 8.
6.2 Environmental precautions
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100997
Product name 1-Propanol for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 6 of 18
Do not let product enter drains. Risk of explosion.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see
sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb® ). Dispose of
properly. Clean up affected area.
6.4 Reference to other sections
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handling
Observe label precautions.
Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition. Take precautionary
measures against static discharge.
Hygiene measures
Change contaminated clothing. Wash hands after working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and
sources of ignition.
Recommended storage temperature see product label.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100997
Product name 1-Propanol for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 7 of 18
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
Contains no substances with occupational exposure limit values.
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Eye/face protection
Tightly fitting safety goggles
Hand protection
full contact:
Glove material: Nitrile rubber
Glove thickness: 0.40 mm
Break through time: > 480 min
splash contact:
Glove material: polychloroprene
Glove thickness: 0.65 mm
Break through time: > 120 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 730 Camatril® -Velours (full
contact), KCL 720 Camapren® (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100997
Product name 1-Propanol for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 8 of 18
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Other protective equipment
Flame retardant antistatic protective clothing.
Respiratory protection
required when vapours/aerosols are generated.
Recommended Filter type: Filter A (acc. to DIN 3181) for vapours of organic compounds
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
Environmental exposure controls
Do not let product enter drains.
Risk of explosion.
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
Form liquid
Colour colourless
Odour alcohol-like
Odour Threshold No information available.
pH 7
at 200 g/l
20 °C
Melting point -127 °C
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100997
Product name 1-Propanol for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 9 of 18
Boiling point/boiling range 96.5 - 98 °C
at 1,013 hPa
Method: DIN 53171
Flash point 15 °C
Method: c.c.
Evaporation rate No information available.
Flammability (solid, gas) No information available.
Lower explosion limit 2.1 %(V)
Upper explosion limit 19.2 %(V)
Vapour pressure 19 hPa
at 20 °C
Relative vapour density 2.1
Density 0.80 g/cm3
at 20 °C
Method: DIN 51757
Relative density No information available.
Water solubility at 20 °C
miscible in all proportions
Partition coefficient: n-
octanol/water
log Pow: 0.25
(experimental)
(IUCLID) Bioaccumulation is not expected.
Auto-ignition temperature No information available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100997
Product name 1-Propanol for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 10 of 18
Decomposition temperature No information available.
Viscosity, dynamic 2.3 mPa.s
at 20 °C
Explosive properties Not classified as explosive.
Oxidizing properties none
9.2 Other data
Ignition temperature 360 °C
Method: DIN 51794
SECTION 10. Stability and reactivity
10.1 Reactivity
Vapours may form explosive mixture with air.
10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.3 Possibility of hazardous reactions
Exothermic reaction with:
Alkaline earth metals, alcoholates
Alkali metals, Release of:, Hydrogen
Violent reactions possible with:
Strong oxidizing agents
10.4 Conditions to avoid
Warming.
10.5 Incompatible materials
rubber, various plastics
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100997
Product name 1-Propanol for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 11 of 18
10.6 Hazardous decomposition products
no information available
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Acute oral toxicity
Symptoms: Risk of aspiration upon vomiting., Aspiration may cause pulmonary oedema and
pneumonitis.
Acute inhalation toxicity
Symptoms: Possible damages:, mucosal irritations
Acute dermal toxicity
This information is not available.
Skin irritation
Rabbit
Result: No irritation
OECD Test Guideline 404
Eye irritation
Rabbit
Result: Severe irritations
OECD Test Guideline 405
Causes serious eye damage.
Sensitisation
Sensitisation test: Guinea pig
Result: negative
(IUCLID)
Patch test: human
Result: negative
(IUCLID)
Germ cell mutagenicity
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100997
Product name 1-Propanol for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 12 of 18
Genotoxicity in vitro
Ames test
Escherichia coli/Salmonella typhimurium
Result: negative
Method: OECD Test Guideline 471
(IUCLID)
Mutagenicity (mammal cell test):
Result: negative
Method: OECD Test Guideline 476
Mutagenicity (mammal cell test): chromosome aberration.
Result: negative
Method: OECD Test Guideline 473
Carcinogenicity
This information is not available.
Reproductive toxicity
This information is not available.
Teratogenicity
This information is not available.
Specific target organ toxicity - single exposure
May cause drowsiness or dizziness.
Target Organs: Central nervous system
Specific target organ toxicity - repeated exposure
This information is not available.
Aspiration hazard
This information is not available.
11.2 Further information
Systemic effects:
Headache, Vertigo, inebriation, Unconsciousness, narcosis
After uptake of large quantities:
respiratory paralysis, Coma
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100997
Product name 1-Propanol for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 13 of 18
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
SECTION 12. Ecological information
12.1 Toxicity
Toxicity to fish
LC50 Pimephales promelas (fathead minnow): 4,630 mg/l; 96 h
(IUCLID)
flow-through test LC50 Pimephales promelas (fathead minnow): 4,555 mg/l; 96 h
Analytical monitoring: yes
OECD Test Guideline 203
Toxicity to daphnia and other aquatic invertebrates
static test EC50 Daphnia magna (Water flea): 3,644 mg/l; 48 h
DIN 38412
Toxicity to algae
static test EC50 Pseudokirchneriella subcapitata (green algae): 9,170 mg/l; 48 h
(ECHA)
Toxicity to bacteria
static test IC50 activated sludge: > 1,000 mg/l; 3 h
OECD Test Guideline 209
Toxicity to daphnia and other aquatic invertebrates (Chronic toxicity)
semi-static test NOEC Daphnia magna (Water flea): > 100 mg/l; 21 d
OECD Test Guideline 211
12.2 Persistence and degradability
Biodegradability
75 %; 20 d; aerobic
(IUCLID)
Readily biodegradable
Chemical Oxygen Demand (COD)
2,230 mg/g
(IUCLID)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100997
Product name 1-Propanol for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 14 of 18
Theoretical oxygen demand (ThOD)
2,400 mg/g
(Lit.)
Ratio BOD/COD
73 %
(IUCLID)
12.3 Bioaccumulative potential
Partition coefficient: n-octanol/water
log Pow: 0.25
(experimental)
(IUCLID) Bioaccumulation is not expected.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
Substance does not meet the criteria for PBT or vPvB according to Regulation (EC) No
1907/2006, Annex XIII.
12.6 Other adverse effects
Discharge into the environment must be avoided.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100997
Product name 1-Propanol for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 15 of 18
SECTION 13. Disposal considerations
Waste treatment methods
Waste material must be disposed of in accordance with the national and local regulations. Leave
chemicals in original containers. No mixing with other waste. Handle uncleaned containers like
the product itself.
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 UN number UN 1274
14.2 Proper shipping name N-PROPANOL
14.3 Class 3
14.4 Packing group II
14.5 Environmentally hazardous --
14.6 Special precautions for
user
yes
Tunnel restriction code D/E
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)
14.1 UN number UN 1274
14.2 Proper shipping name N-PROPANOL
14.3 Class 3
14.4 Packing group II
14.5 Environmentally hazardous --
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100997
Product name 1-Propanol for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 16 of 18
14.6 Special precautions for
user
no
Sea transport (IMDG)
14.1 UN number UN 1274
14.2 Proper shipping name N-PROPANOL
14.3 Class 3
14.4 Packing group II
14.5 Environmentally hazardous --
14.6 Special precautions for
user
yes
EmS F-E S-D
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National legislation
Storage class 3
15.2 Chemical safety assessment
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Full text of H-Statements referred to under sections 2 and 3.
H225 Highly flammable liquid and vapour.
H318 Causes serious eye damage.
H336 May cause drowsiness or dizziness.
Training advice
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100997
Product name 1-Propanol for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 17 of 18
Provide adequate information, instruction and training for operators.
Labelling
Hazard pictograms
Signal word
Danger
Hazard statements
H225 Highly flammable liquid and vapour.
H318 Causes serious eye damage.
H336 May cause drowsiness or dizziness.
Precautionary statements
Prevention
P210 Keep away from heat/sparks/open flames/hot surfaces. No smoking.
P240 Ground/bond container and receiving equipment.
P280 Wear eye protection.
Response
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
P313 Get medical advice/ attention.
Storage
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100997
Product name 1-Propanol for analysis EMSURE® ACS,Reag. Ph Eur
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 18 of 18
The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006
Revision Date 29.06.2015 Version 1.3
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 8
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 106643
Product name Sodium sulfate anhydrous EMPROVE® ESSENTIAL Ph
Eur,BP,USP,E 514
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.
CAS-No. 7757-82-6
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Pharmaceutical production, Cosmetic raw material
For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * 8th Floor, Godrej One,
Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079
India * Tel: 0091 22 6210 9000
Responsible Department Quality Assurance * Merck Life Science Private Limited *
e-mail: [email protected] *
Tel : +91-2267863131-6
1.4 Notrufnummer Please contact the regional company representation in your country.
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
This substance is not classified as dangerous according to European Union legislation.
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
2.3 Other hazards
None known.
SECTION 3. Composition/information on ingredients
3.1 Substance
Formula Na₂SO₄ Na₂O₄S (Hill)
EC-No. 231-820-9
Molar mass 142.04 g/mol
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106643
Product name Sodium sulfate anhydrous EMPROVE® ESSENTIAL Ph Eur,BP,USP,E 514
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 8
Remarks No disclosure requirement according to Regulation (EC) No.
1907/2006
3.2 Mixture
Not applicable
SECTION 4. First aid measures
4.1 Description of first aid measures
After inhalation: fresh air.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower.
After eye contact: rinse out with plenty of water.
After swallowing: make victim drink water (two glasses at most). Consult doctor if feeling unwell.
4.2 Most important symptoms and effects, both acute and delayed
Nausea, Vomiting, cardiovascular disorders
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SECTION 5. Firefighting measures
5.1 Extinguishing media
Suitable extinguishing mediaUse extinguishing measures that are appropriate to local circumstances and the surrounding
environment.
Unsuitable extinguishing mediaFor this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Not combustible.
Ambient fire may liberate hazardous vapours.
Fire may cause evolution of:
Sulphur oxides
5.3 Advice for firefighters
Special protective equipment for firefightersIn the event of fire, wear self-contained breathing apparatus.
Further informationSuppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing
water from contaminating surface water or the ground water system.
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid inhalation of dusts. Evacuate the danger area,
observe emergency procedures, consult an expert.
Advice for emergency responders:
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106643
Product name Sodium sulfate anhydrous EMPROVE® ESSENTIAL Ph Eur,BP,USP,E 514
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 8
Protective equipment see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see
sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation
of dusts.
6.4 Reference to other sections
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handlingObserve label precautions.
Hygiene measuresChange contaminated clothing. Wash hands after working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditionsTightly closed. Dry.
Recommended storage temperature see product label.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
Contains no substances with occupational exposure limit values.
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Eye/face protectionSafety glasses
Hand protection
full contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106643
Product name Sodium sulfate anhydrous EMPROVE® ESSENTIAL Ph Eur,BP,USP,E 514
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 4 of 8
splash contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 741 Dermatril® L (full contact),
KCL 741 Dermatril® L (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Respiratory protectionrequired when dusts are generated.
Recommended Filter type: Filter P 1 (acc. to DIN 3181) for solid particles of inert substances
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
Environmental exposure controls
Do not let product enter drains.
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
Form solid
Colour white
Odour odourless
Odour Threshold Not applicable
pH 5.2 - 8.0
at 50 g/l
20 °C
Melting point 888 °C
Boiling point/boiling range Not applicable, (decomposition)
Flash point Not applicable
Evaporation rate No information available.
Flammability (solid, gas) The product is not flammable.
Lower explosion limit No information available.
Upper explosion limit No information available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106643
Product name Sodium sulfate anhydrous EMPROVE® ESSENTIAL Ph Eur,BP,USP,E 514
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 5 of 8
Vapour pressure Not applicable
Relative vapour density No information available.
Density 2.70 g/cm³
at 20 °C
Relative density No information available.
Water solubility 200 g/l
at 20 °C
Partition coefficient: n-
octanol/water
Not applicable
Auto-ignition temperature > 400 °C
Method: NF T 20-036
does not ignite
Decomposition temperature > 890 °C
Viscosity, dynamic No information available.
Explosive properties Not classified as explosive.
Oxidizing properties none
9.2 Other data
Ignition temperature Not applicable
Bulk density ca.1,400 - 1,600 kg/m³
SECTION 10. Stability and reactivity
10.1 Reactivity
See section 10.3
10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.3 Possibility of hazardous reactions
Risk of explosion with:
smelt, with, Aluminium
10.4 Conditions to avoid
no information available
10.5 Incompatible materials
no information available
10.6 Hazardous decomposition products
in the event of fire: See section 5.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106643
Product name Sodium sulfate anhydrous EMPROVE® ESSENTIAL Ph Eur,BP,USP,E 514
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 6 of 8
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Acute oral toxicityLD50 Rat: > 2,000 mg/kg
OECD Test Guideline 423
(ECHA)
Symptoms: Possible damages:, Nausea, Vomiting
Acute inhalation toxicityThis information is not available.
Acute dermal toxicityThis information is not available.
Skin irritationRabbit
Result: No irritation
OECD Test Guideline 404
Eye irritationRabbit
Result: slight irritation
OECD Test Guideline 405
SensitisationThis information is not available.
Germ cell mutagenicity
Genotoxicity in vitroAmes test
Result: negative
(IUCLID)
CarcinogenicityThis information is not available.
Reproductive toxicityThis information is not available.
TeratogenicityThis information is not available.
Specific target organ toxicity - single exposureThis information is not available.
Specific target organ toxicity - repeated exposureThis information is not available.
Aspiration hazardThis information is not available.
11.2 Further information
Systemic effects:
After uptake of large quantities:
cardiovascular disorders
Symptoms in:
Gastrointestinal tract
However, when the product is handled appropriately, hazardous effects are unlikely to occur.
Handle in accordance with good industrial hygiene and safety practice.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106643
Product name Sodium sulfate anhydrous EMPROVE® ESSENTIAL Ph Eur,BP,USP,E 514
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 7 of 8
SECTION 12. Ecological information
12.1 Toxicity
Toxicity to fishLC50 Gambusia affinis (Mosquito fish): 120 mg/l; 96 h
(IUCLID)
Toxicity to daphnia and other aquatic invertebratesEC50 Daphnia magna (Water flea): 2,564 mg/l; 48 h
(IUCLID)
Toxicity to bacteriaEC10 Pseudomonas putida: > 1,000 mg/l; 16 h
(IUCLID)
12.2 Persistence and degradability
No information available.
12.3 Bioaccumulative potential
Partition coefficient: n-octanol/water
Not applicable
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.
12.6 Other adverse effects
Additional ecological informationDischarge into the environment must be avoided.
SECTION 13. Disposal considerations
Waste treatment methodsWaste material must be disposed of in accordance with the national and local regulations. Leave
chemicals in original containers. No mixing with other waste. Handle uncleaned containers like
the product itself.
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Sea transport (IMDG)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106643
Product name Sodium sulfate anhydrous EMPROVE® ESSENTIAL Ph Eur,BP,USP,E 514
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 8 of 8
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National legislation
Storage class 10 - 13
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Training advice
Provide adequate information, instruction and training for operators.
Labelling (67/548/EEC or 1999/45/EC)
The product does not need to be labelled in accordance with EC directives or respective national
laws.
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
The information contained herein is based on the present state of our knowledge. It characterises the product with regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Revision Date 20.12.2016 Version 1.2
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 11
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 106585
Product name di-Sodium hydrogen phosphate anhydrous EMPROVE® ESSENTIAL
Ph Eur,BP,USP,JPE,E 339
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.
CAS-No. 7558-79-4
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Pharmaceutical production, Cosmetic raw material
For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * 8th Floor, Godrej One,
Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079
India * Tel: 0091 22 6210 9000
Responsible Department Quality Assurance * Merck Life Science Private Limited *
e-mail: [email protected] *
Tel : +91-2267863131-6
1.4 Emergency telephone
number
Please contact the regional company representation in your country.
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
This substance is not classified as dangerous according to European Union legislation.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106585
Product name di-Sodium hydrogen phosphate anhydrous EMPROVE® ESSENTIAL Ph
Eur,BP,USP,JPE,E 339
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 11
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
2.3 Other hazards
None known.
SECTION 3. Composition/information on ingredients
3.1 Substance
Formula Na₂HPO₄ HNa₂O₄P (Hill)
EC-No. 231-448-7
Molar mass 141.96 g/mol
Remarks No disclosure requirement according to Regulation (EC) No.
1907/2006.
3.2 Mixture
Not applicable
SECTION 4. First aid measures
4.1 Description of first aid measures
After inhalation: fresh air.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower.
After eye contact: rinse out with plenty of water with the eyelid held wide open. Call in
ophthalmologist if necessary.
After swallowing: make victim drink water (two glasses at most). Consult doctor if feeling unwell.
4.2 Most important symptoms and effects, both acute and delayed
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106585
Product name di-Sodium hydrogen phosphate anhydrous EMPROVE® ESSENTIAL Ph
Eur,BP,USP,JPE,E 339
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 11
irritant effects
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SECTION 5. Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Use extinguishing measures that are appropriate to local circumstances and the surrounding
environment.
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Not combustible.
Ambient fire may liberate hazardous vapours.
Fire may cause evolution of:
Oxides of phosphorus
5.3 Advice for firefighters
Special protective equipment for firefighters
In the event of fire, wear self-contained breathing apparatus.
Further information
Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing
water from contaminating surface water or the ground water system.
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid inhalation of dusts. Evacuate the danger area,
observe emergency procedures, consult an expert.
Advice for emergency responders:
Protective equipment see section 8.
6.2 Environmental precautions
Do not let product enter drains.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106585
Product name di-Sodium hydrogen phosphate anhydrous EMPROVE® ESSENTIAL Ph
Eur,BP,USP,JPE,E 339
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 4 of 11
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see
sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation
of dusts.
6.4 Reference to other sections
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handling
Observe label precautions.
Hygiene measures
Change contaminated clothing. Wash hands after working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed. Dry.
Recommended storage temperature see product label.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
Contains no substances with occupational exposure limit values.
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106585
Product name di-Sodium hydrogen phosphate anhydrous EMPROVE® ESSENTIAL Ph
Eur,BP,USP,JPE,E 339
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 5 of 11
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Eye/face protection
Safety glasses
Hand protection
full contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
splash contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 741 Dermatril® L (full contact),
KCL 741 Dermatril® L (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Respiratory protection
required when dusts are generated.
Recommended Filter type: Filter P 1 (acc. to DIN 3181) for solid particles of inert substances
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
Environmental exposure controls
Do not let product enter drains.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106585
Product name di-Sodium hydrogen phosphate anhydrous EMPROVE® ESSENTIAL Ph
Eur,BP,USP,JPE,E 339
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 6 of 11
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
Form solid
Colour white
Odour odourless
Odour Threshold Not applicable
pH 8.7 - 9.3
at 10 g/l
20 °C
Melting point ca. 250 °C
(decomposition)
Boiling point No information available.
Flash point does not flash
Evaporation rate No information available.
Flammability (solid, gas) The product is not flammable.
Lower explosion limit Not applicable
Upper explosion limit Not applicable
Vapour pressure No information available.
Relative vapour density No information available.
Density No information available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106585
Product name di-Sodium hydrogen phosphate anhydrous EMPROVE® ESSENTIAL Ph
Eur,BP,USP,JPE,E 339
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 7 of 11
Relative density No information available.
Water solubility 77 g/l
at 20 °C
Partition coefficient: n-
octanol/water
No information available.
Auto-ignition temperature No information available.
Decomposition temperature > 250 °C
Viscosity, dynamic No information available.
Explosive properties Not applicable
Oxidizing properties none
9.2 Other data
Ignition temperature not combustible
Bulk density ca.880 kg/m3
SECTION 10. Stability and reactivity
10.1 Reactivity
See section 10.3
10.2 Chemical stability
hygroscopic
10.3 Possibility of hazardous reactions
Exothermic reaction with:
Strong acids, antipyrine, acetates
10.4 Conditions to avoid
no information available
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106585
Product name di-Sodium hydrogen phosphate anhydrous EMPROVE® ESSENTIAL Ph
Eur,BP,USP,JPE,E 339
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 8 of 11
10.5 Incompatible materials
no information available
10.6 Hazardous decomposition products
in the event of fire: See section 5.
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Acute oral toxicity
LD50 Rat: > 2,000 mg/kg
OECD Test Guideline 420
Acute inhalation toxicity
This information is not available.
Acute dermal toxicity
This information is not available.
Skin irritation
Rabbit
Result: No irritation
OECD Test Guideline 404
After long-term exposure to the chemical: slight irritation
Eye irritation
After long-term exposure to the chemical: slight irritation
Sensitisation
This information is not available.
Germ cell mutagenicity
Genotoxicity in vitro
Ames test
Salmonella typhimurium
Result: negative
Method: OECD Test Guideline 471
Carcinogenicity
This information is not available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106585
Product name di-Sodium hydrogen phosphate anhydrous EMPROVE® ESSENTIAL Ph
Eur,BP,USP,JPE,E 339
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 9 of 11
Reproductive toxicity
This information is not available.
Teratogenicity
This information is not available.
Specific target organ toxicity - single exposure
This information is not available.
Specific target organ toxicity - repeated exposure
This information is not available.
Aspiration hazard
This information is not available.
11.2 Further information
However, when the product is handled appropriately, hazardous effects are unlikely to occur.
Handle in accordance with good industrial hygiene and safety practice.
SECTION 12. Ecological information
12.1 Toxicity
Toxicity to fish
LC50 Gambusia affinis (Mosquito fish): 467 mg/l; 48 h
(Lit.)
Toxicity to daphnia and other aquatic invertebrates
EC50 Daphnia magna (Water flea): 1,089 mg/l; 48 h
(Lit.)
12.2 Persistence and degradability
No information available.
12.3 Bioaccumulative potential
No information available.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.
12.6 Other adverse effects
Additional ecological information
Discharge into the environment must be avoided.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106585
Product name di-Sodium hydrogen phosphate anhydrous EMPROVE® ESSENTIAL Ph
Eur,BP,USP,JPE,E 339
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 10 of 11
SECTION 13. Disposal considerations
Waste treatment methods
Waste material must be disposed of in accordance with the national and local regulations. Leave
chemicals in original containers. No mixing with other waste. Handle uncleaned containers like
the product itself.
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Sea transport (IMDG)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National legislation
Storage class 10 - 13
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 106585
Product name di-Sodium hydrogen phosphate anhydrous EMPROVE® ESSENTIAL Ph
Eur,BP,USP,JPE,E 339
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 11 of 11
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Training advice
Provide adequate information, instruction and training for operators.
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Revision Date 26.09.2016 Version 1.1
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 12
SECTION 1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Catalogue No. 100590
Product name Glycine cryst. suitable for use as excipient EMPROVE® exp
Ph.Eur.,BP,JP,USP
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.
CAS-No. 56-40-6
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Food and pharmaceutical industry
For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck Life Science Private Limited * 8th Floor, Godrej One,
Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079
India * Tel: 0091 22 6210 9000
Responsible Department Quality Assurance * Merck Life Science Private Limited *
e-mail: [email protected] *
Tel : +91-2267863131-6
1.4 Emergency telephone
number
Please contact the regional company representation in your country.
SECTION 2. Hazards identification
2.1 Classification of the substance or mixture
This substance is not classified as dangerous according to European Union legislation.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100590
Product name Glycine cryst. suitable for use as excipient EMPROVE® exp Ph.Eur.,BP,JP,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 2 of 12
2.2 Label elements
Labelling (REGULATION (EC) No 1272/2008)
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
2.3 Other hazards
None known.
SECTION 3. Composition/information on ingredients
3.1 Substance
Formula H₂NCH₂COOH C₂H₅NO₂ (Hill)
EC-No. 200-272-2
Molar mass 75.06 g/mol
Remarks No disclosure requirement according to Regulation (EC) No.
1907/2006.
3.2 Mixture
Not applicable
SECTION 4. First aid measures
4.1 Description of first aid measures
After inhalation: fresh air.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower.
After eye contact: rinse out with plenty of water. Remove contact lenses.
After swallowing: make victim drink water (two glasses at most). Consult doctor if feeling unwell.
4.2 Most important symptoms and effects, both acute and delayed
We have no description of any toxic symptoms.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100590
Product name Glycine cryst. suitable for use as excipient EMPROVE® exp Ph.Eur.,BP,JP,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 3 of 12
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SECTION 5. Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Water, Foam, Carbon dioxide (CO2), Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Combustible.
Development of hazardous combustion gases or vapours possible in the event of fire.
Fire may cause evolution of:
nitrous gases, nitrogen oxides
5.3 Advice for firefighters
Special protective equipment for firefighters
In the event of fire, wear self-contained breathing apparatus.
Further information
Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing
water from contaminating surface water or the ground water system.
SECTION 6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid inhalation of dusts. Evacuate the danger area,
observe emergency procedures, consult an expert.
Advice for emergency responders:
Protective equipment see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100590
Product name Glycine cryst. suitable for use as excipient EMPROVE® exp Ph.Eur.,BP,JP,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 4 of 12
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see
sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation
of dusts.
6.4 Reference to other sections
Indications about waste treatment see section 13.
SECTION 7. Handling and storage
7.1 Precautions for safe handling
Advice on safe handling
Observe label precautions.
Hygiene measures
Change contaminated clothing. Wash hands after working with substance.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed. Dry.
Recommended storage temperature see product label.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8. Exposure controls/personal protection
8.1 Control parameters
Contains no substances with occupational exposure limit values.
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100590
Product name Glycine cryst. suitable for use as excipient EMPROVE® exp Ph.Eur.,BP,JP,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 5 of 12
Individual protection measures
Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Eye/face protection
Safety glasses
Hand protection
full contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
splash contact:
Glove material: Nitrile rubber
Glove thickness: 0.11 mm
Break through time: > 480 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 741 Dermatril® L (full contact),
KCL 741 Dermatril® L (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Respiratory protection
required when dusts are generated.
Recommended Filter type: Filter P 1 (acc. to DIN 3181) for solid particles of inert substances
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
Environmental exposure controls
Do not let product enter drains.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100590
Product name Glycine cryst. suitable for use as excipient EMPROVE® exp Ph.Eur.,BP,JP,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 6 of 12
SECTION 9. Physical and chemical properties
9.1 Information on basic physical and chemical properties
Form solid
Colour white
Odour odourless
Odour Threshold Not applicable
pH 5.9 - 6.4
at 50 g/l
20 °C
Melting point 233 °C
(decomposition)
Boiling point/boiling range Not applicable
Flash point Not applicable
Evaporation rate No information available.
Flammability (solid, gas) The product is not flammable.
Test N.1: Test method for readily combustible solids
Lower explosion limit No information available.
Upper explosion limit No information available.
Vapour pressure 0.0000171 Pa
at 25 °C
Relative vapour density No information available.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100590
Product name Glycine cryst. suitable for use as excipient EMPROVE® exp Ph.Eur.,BP,JP,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 7 of 12
Density 1.161 g/cm3
at 20 °C
Relative density No information available.
Water solubility 250 g/l
at 25 °C
soluble
Partition coefficient: n-
octanol/water
log Pow: -3.21
(calculated)
(Lit.) Bioaccumulation is not expected.
Auto-ignition temperature not auto-flammable
Decomposition temperature > 233 °C
Viscosity, dynamic Not applicable
Explosive properties Not classified as explosive.
Oxidizing properties none
9.2 Other data
Bulk density 920 kg/m3
Particle size < 0.1 mm
Method: OECD Test Guideline 110
SECTION 10. Stability and reactivity
10.1 Reactivity
The following applies in general to flammable organic substances and mixtures: in
correspondingly fine distribution, when whirled up a dust explosion potential may generally be
assumed.
10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100590
Product name Glycine cryst. suitable for use as excipient EMPROVE® exp Ph.Eur.,BP,JP,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 8 of 12
10.3 Possibility of hazardous reactions
Violent reactions possible with:
Strong oxidizing agents, Bases
10.4 Conditions to avoid
no information available
10.5 Incompatible materials
no information available
10.6 Hazardous decomposition products
in the event of fire: See section 5.
SECTION 11. Toxicological information
11.1 Information on toxicological effects
Acute oral toxicity
LD50 Rat: 7,930 mg/kg
(External MSDS)
Acute inhalation toxicity
This information is not available.
Acute dermal toxicity
This information is not available.
Skin irritation
This information is not available.
Eye irritation
This information is not available.
Sensitisation
Sensitisation test: Mouse
Result: negative
Method: OECD Test Guideline 429
Germ cell mutagenicity
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100590
Product name Glycine cryst. suitable for use as excipient EMPROVE® exp Ph.Eur.,BP,JP,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 9 of 12
Genotoxicity in vitro
reverse mutation assay
Escherichia coli/Salmonella typhimurium
Result: negative
Method: OECD Test Guideline 471
In vitro mammalian cell gene mutation test
Mouse lymphoma test
Result: negative
Method: OECD Test Guideline 476
Ames test
Salmonella typhimurium
Result: negative
Method: OECD Test Guideline 471
(National Toxicology Program)
Carcinogenicity
This information is not available.
Reproductive toxicity
This information is not available.
Teratogenicity
This information is not available.
Specific target organ toxicity - single exposure
This information is not available.
Specific target organ toxicity - repeated exposure
This information is not available.
Aspiration hazard
This information is not available.
11.2 Further information
This is a non-essential amino acid that occurs in many forms in natural protein.
Therapeutically used substance.
No toxic effects are to be expected when the product is handled appropriately.
Handle in accordance with good industrial hygiene and safety practice.
SECTION 12. Ecological information
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100590
Product name Glycine cryst. suitable for use as excipient EMPROVE® exp Ph.Eur.,BP,JP,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 10 of 12
12.1 Toxicity
Toxicity to fish
static test LC50 Oryzias latipes (Orange-red killifish): > 1,000 mg/l; 96 h
OECD Test Guideline 203
Toxicity to daphnia and other aquatic invertebrates
semi-static test EC50 Daphnia magna (Water flea): > 220 mg/l; 48 h
Analytical monitoring: yes
OECD Test Guideline 202
Toxicity to algae
static test EC50 Pseudokirchneriella subcapitata (green algae): > 1,000 mg/l; 72 h
OECD Test Guideline 201
Toxicity to bacteria
static test NOEC activated sludge: >= 100 mg/l; 14 d
(ECHA)
12.2 Persistence and degradability
Biodegradability
76 - 82 %; 14 d; aerobic
OECD Test Guideline 301C
Readily biodegradable
12.3 Bioaccumulative potential
Partition coefficient: n-octanol/water
log Pow: -3.21
(calculated)
(Lit.) Bioaccumulation is not expected.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.
12.6 Other adverse effects
Discharge into the environment must be avoided.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100590
Product name Glycine cryst. suitable for use as excipient EMPROVE® exp Ph.Eur.,BP,JP,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 11 of 12
SECTION 13. Disposal considerations
Waste treatment methods
Waste material must be disposed of in accordance with the national and local regulations. Leave
chemicals in original containers. No mixing with other waste. Handle uncleaned containers like
the product itself.
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information
Land transport (ADR/RID)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
Sea transport (IMDG)
14.1 - 14.6 Not classified as dangerous in the meaning of transport
regulations.
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National legislation
Storage class 10 - 13
15.2 Chemical Safety Assessment
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Catalogue No. 100590
Product name Glycine cryst. suitable for use as excipient EMPROVE® exp Ph.Eur.,BP,JP,USP
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 12 of 12
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Training advice
Provide adequate information, instruction and training for operators.
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
Version: 1.3 Revision Date: 12-01-2017
SDS_US - SDSMIX000331 1/11
SAFETY DATA SHEET According to US Regulation 29 CFR 1910.1200 (HazCom 2012)
1. Identification
Product identifier: Phosphoric Acid
Other means of identification
Synonyms: Ortho-Phosphoric Acid, White Phosphoric Acid Product No.: 0240, 6908, 2798, 2797, 5854, 2796, 5804, 2788, 0259, 5372,
0274, 0269, 0268, 0265, 0264, 0262, 0260, 0255, 0251, 6168
Recommended restrictions
Recommended use: For Laboratory, Research or Manufacturing Use. Restrictions on use: Not determined.
Details of the supplier of the safety data sheet
Manufacturer
Company Name: Avantor Performance Materials, LLC. Address: 3477 Corporate Parkway
Center Valley, PA 18034
Telephone: Customer Service: 855-282-6867
Fax: 610-573-2610 Contact Person: Environmental Health & Safety E-mail: [email protected]
Emergency telephone number: CHEMTREC: 1-800-424-9300 within US and Canada
2. Hazard(s) identification
Hazard Classification
Physical Hazards
Corrosive to metals Category 1
Health Hazards
Acute toxicity (Oral) Category 4
Acute toxicity (Dermal) Category 5
Skin Corrosion/Irritation Category 1A
Serious Eye Damage/Eye Irritation Category 1
Specific Target Organ Toxicity - Single Exposure
Category 31.
Target Organs
1. Respiratory tract irritation.
Unknown toxicity - Health
Acute toxicity, oral 0 %
Acute toxicity, dermal 0 %
Acute toxicity, inhalation, vapor 84 %
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SDS_US - SDSMIX000331 2/11
Acute toxicity, inhalation, dust or mist
84 %
Hazard Symbol:
Signal Word: Danger
Hazard Statement: May be corrosive to metals. Harmful if swallowed. Causes severe skin burns and eye damage. May cause respiratory irritation.
Precautionary Statements
Prevention: Keep only in original packaging. Do not breathe dust/fume/mist/vapors. Do
not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling.
Response: Absorb spillage to prevent material damage. IF SWALLOWED: Rinse
mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower]. Wash contaminated clothing before reuse. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER or doctor/physician.
Storage: Store locked up. Store in a well-ventilated place. Keep container tightly
closed. Store in a corrosion-resistant container with a resistant inner liner.
Disposal: Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Hazard(s) not otherwise classified (HNOC):
None.
3. Composition/information on ingredients
Mixtures
Chemical Identity CAS number Content in percent (%)*
Phosphoric acid 7664-38-2 80 - 90% * All concentrations are percent by weight unless ingredient is a gas. Gas concentrations are in percent by volume.
4. First-aid measures
Label Elements
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SDS_US - SDSMIX000331 3/11
General information: Get medical advice/attention if you feel unwell. Show this safety data sheet
to the doctor in attendance. Ingestion: Do NOT induce vomiting. Call a physician or poison control center
immediately. If vomiting occurs, keep head low so that stomach content doesn't get into the lungs.
Inhalation: Move to fresh air. Call a physician or poison control center immediately.
Apply artificial respiration if victim is not breathing If breathing is difficult, give oxygen.
Skin Contact: Immediately flush with plenty of water for at least 15 minutes while
removing contaminated clothing and shoes. Call a physician or poison control center immediately. Wash contaminated clothing before reuse. Destroy or thoroughly clean contaminated shoes.
Eye contact: Immediately flush with plenty of water for at least 15 minutes. If easy to do,
remove contact lenses. Call a physician or poison control center immediately. In case of irritation from airborne exposure, move to fresh air. Get medical attention immediately.
Most important symptoms/effects, acute and delayed
Symptoms: Causes severe skin and eye burns. Causes digestive tract burns.
Hazards: None known.
Indication of immediate medical attention and special treatment needed
Treatment: Treat symptomatically. Symptoms may be delayed.
5. Fire-fighting measures
General Fire Hazards: Product is highly acidic. Wear protective gear if spilled during fire fighting.
Suitable (and unsuitable) extinguishing media
Suitable extinguishing media:
The product is non-combustible. Use fire-extinguishing media appropriate for surrounding materials.
Unsuitable extinguishing media:
None known.
Specific hazards arising from
the chemical: Not combustible, but if involved in a fire decomposes to produce toxic gases.
Special protective equipment and precautions for firefighters
Special fire fighting procedures:
Move containers from fire area if you can do so without risk. Use water spray to keep fire-exposed containers cool. Cool containers exposed to flames with water until well after the fire is out.
Special protective equipment for fire-fighters:
Firefighters must use standard protective equipment including flame retardant coat, helmet with face shield, gloves, rubber boots, and in enclosed spaces, SCBA. Product is highly acidic. Wear protective gear if spilled during fire fighting.
6. Accidental release measures
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SDS_US - SDSMIX000331 4/11
Personal precautions,
protective equipment and emergency procedures:
See Section 8 of the SDS for Personal Protective Equipment. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Keep unauthorized personnel away. Keep upwind. Ventilate closed spaces before entering them.
Methods and material for
containment and cleaning up:
Neutralize with lime or soda ash. Absorb spill with vermiculite or other inert material, then place in a container for chemical waste. Clean surface thoroughly to remove residual contamination. Dike far ahead of larger spill for later recovery and disposal.
Notification Procedures: Inform authorities if large amounts are involved.
Environmental Precautions: Do not contaminate water sources or sewer. Prevent further leakage or
spillage if safe to do so.
7. Handling and storage
Precautions for safe handling: Do not get in eyes, on skin, on clothing. Do not taste or swallow. Wash
thoroughly after handling. Do not eat, drink or smoke when using the product. Use caution when adding this material to water. Add material slowly when mixing with water. Do not add water to the material; instead, add the material to the water.
Conditions for safe storage,
including any incompatibilities:
Do not store in metal containers. Keep container tightly closed. Store in a well-ventilated place.
8. Exposure controls/personal protection
Control Parameters
Occupational Exposure Limits
Chemical Identity Type Exposure Limit Values Source
Phosphoric acid TWA 1 mg/m3 US. ACGIH Threshold Limit Values (2011)
STEL 3 mg/m3 US. ACGIH Threshold Limit Values (2011)
REL 1 mg/m3 US. NIOSH: Pocket Guide to Chemical Hazards (2010)
STEL 3 mg/m3 US. NIOSH: Pocket Guide to Chemical Hazards (2010)
PEL 1 mg/m3 US. OSHA Table Z-1 Limits for Air Contaminants (29 CFR 1910.1000) (02 2006)
TWA 1 mg/m3 US. OSHA Table Z-1-A (29 CFR 1910.1000) (1989)
STEL 3 mg/m3 US. OSHA Table Z-1-A (29 CFR 1910.1000) (1989)
TWA 1 mg/m3 US. Tennessee. OELs. Occupational Exposure Limits, Table Z1A (06 2008)
STEL 3 mg/m3 US. Tennessee. OELs. Occupational Exposure Limits, Table Z1A (06 2008)
ST ESL 10 µg/m3 US. Texas. Effects Screening Levels (Texas Commission on Environmental Quality) (12 2010)
AN ESL 1 µg/m3 US. Texas. Effects Screening Levels (Texas Commission on Environmental Quality) (12 2010)
TWA PEL 1 mg/m3 US. California Code of Regulations, Title 8, Section 5155. Airborne Contaminants (08 2010)
STEL 3 mg/m3 US. California Code of Regulations, Title 8, Section 5155. Airborne Contaminants (08 2010)
Version: 1.3 Revision Date: 12-01-2017
SDS_US - SDSMIX000331 5/11
Appropriate Engineering Controls
No data available.
Individual protection measures, such as personal protective equipment
General information: Good general ventilation (typically 10 air changes per hour) should be used.
Ventilation rates should be matched to conditions. If applicable, use process enclosures, local exhaust ventilation, or other engineering controls to maintain airborne levels below recommended exposure limits. If exposure limits have not been established, maintain airborne levels to an acceptable level. An eye wash and safety shower must be available in the immediate work area.
Eye/face protection: Wear safety glasses with side shields (or goggles) and a face shield.
Skin Protection
Hand Protection: Chemical resistant gloves
Other: Wear suitable protective clothing and gloves.
Respiratory Protection: In case of inadequate ventilation use suitable respirator. Respirator type: Chemical respirator with acid gas cartridge.
Hygiene measures: Provide eyewash station and safety shower. Observe good industrial
hygiene practices. Wash hands before breaks and immediately after handling the product. Wash contaminated clothing before reuse. Avoid contact with eyes. Avoid contact with skin.
9. Physical and chemical properties
Appearance
Physical state: Liquid
Form: Liquid
Color: Colorless
Odor: Odorless
Odor threshold: No data available.
pH: 1.5 (3.27 g/l, 20 °C)
Melting point/freezing point: 21.1 °C
Initial boiling point and boiling range: 158 °C
Flash Point: not applicable
Evaporation rate: No data available.
Flammability (solid, gas): No data available.
Upper/lower limit on flammability or explosive limits
Flammability limit - upper (%): No data available.
Flammability limit - lower (%): No data available.
Explosive limit - upper (%): No data available.
Explosive limit - lower (%): No data available.
Vapor pressure: 0.3 kPa
Vapor density: No data available.
Density: 1.69 g/ml (20 °C)
Relative density: 1.69 (20 °C)
Solubility(ies)
Solubility in water: Miscible with water.
Solubility (other): No data available.
Version: 1.3 Revision Date: 12-01-2017
SDS_US - SDSMIX000331 6/11
Partition coefficient (n-octanol/water): No data available.
Auto-ignition temperature: No data available.
Decomposition temperature: No data available.
Viscosity: No data available.
10. Stability and reactivity
Reactivity: No dangerous reaction known under conditions of normal use.
Chemical Stability: Material is stable under normal conditions.
Possibility of hazardous
reactions: Hazardous polymerization does not occur.
Conditions to avoid: Avoid contact with oxidizing agents. Avoid contact with strong reducing
agents. Contact with alkalis. Incompatible Materials: Strong reducing agents. Alkalies. Strong oxidizing agents. Metals.
Hazardous Decomposition
Products: oxides of phosphorus
11. Toxicological information
Information on likely routes of exposure
Inhalation: Severely irritating to respiratory system.
Skin Contact: Causes severe skin burns.
Eye contact: Causes serious eye damage.
Ingestion: Harmful if swallowed.
Information on toxicological effects
Acute toxicity (list all possible routes of exposure)
Oral Product: ATEmix (Rat): 1,700 mg/kg
Dermal
Product: ATEmix (Rabbit) 3,044.44 mg/kg
Inhalation Product: Not classified for acute toxicity based on available data.
Repeated dose toxicity Product: No data available.
Skin Corrosion/Irritation Product: Causes severe skin burns.
Serious Eye Damage/Eye Irritation
Product: Causes serious eye damage.
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SDS_US - SDSMIX000331 7/11
Respiratory or Skin Sensitization Product: Not a skin sensitizer.
Carcinogenicity
Product: This substance has no evidence of carcinogenic properties.
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: No carcinogenic components identified
US. National Toxicology Program (NTP) Report on Carcinogens: No carcinogenic components identified
US. OSHA Specifically Regulated Substances (29 CFR 1910.1001-1050): No carcinogenic components identified
Germ Cell Mutagenicity
In vitro Product: No mutagenic components identified
In vivo
Product: No mutagenic components identified
Reproductive toxicity Product: No components toxic to reproduction
Specific Target Organ Toxicity - Single Exposure
Product: None known.
Specific Target Organ Toxicity - Repeated Exposure Product: None known.
Target Organs Specific Target Organ Toxicity - Single Exposure: Respiratory tract irritation.
Aspiration Hazard
Product: Not classified
Other effects: Not known.
12. Ecological information
Ecotoxicity:
Acute hazards to the aquatic environment:
Fish Product: No data available.
Aquatic Invertebrates
Product: No data available.
Chronic hazards to the aquatic environment:
Fish Product: No data available.
Version: 1.3 Revision Date: 12-01-2017
SDS_US - SDSMIX000331 8/11
Aquatic Invertebrates
Product: No data available.
Toxicity to Aquatic Plants Product: No data available.
Persistence and Degradability
Biodegradation
Product: Expected to be readily biodegradable.
BOD/COD Ratio Product: No data available.
Bioaccumulative potential
Bioconcentration Factor (BCF) Product: No data available on bioaccumulation.
Partition Coefficient n-octanol / water (log Kow)
Product: No data available. Mobility in soil: The product is water soluble and may spread in water systems.
Other adverse effects: The product may affect the acidity (pH-factor) in water with risk of harmful
effects to aquatic organisms.
13. Disposal considerations
Disposal instructions: Discharge, treatment, or disposal may be subject to national, state, or local
laws. Contaminated Packaging: Since emptied containers retain product residue, follow label warnings even
after container is emptied.
14. Transport information
DOT
UN Number: UN 1805 UN Proper Shipping Name: Phosphoric acid solution Transport Hazard Class(es)
Class: 8 Label(s): 8
Packing Group: III Marine Pollutant: No Special precautions for user: Not determined.
IMDG
UN Number: UN 1805 UN Proper Shipping Name: PHOSPHORIC ACID SOLUTION Transport Hazard Class(es)
Class: 8 Label(s): 8 EmS No.: F-A, S-B
Packing Group: III Marine Pollutant: No
Version: 1.3 Revision Date: 12-01-2017
SDS_US - SDSMIX000331 9/11
Special precautions for user: Not determined.
IATA UN Number: UN 1805 Proper Shipping Name: Phosphoric acid, solution Transport Hazard Class(es):
Class: 8 Label(s): 8
Packing Group: III Marine Pollutant: No Special precautions for user: Not determined.
15. Regulatory information
US Federal Regulations
TSCA Section 12(b) Export Notification (40 CFR 707, Subpt. D) None present or none present in regulated quantities.
US. OSHA Specifically Regulated Substances (29 CFR 1910.1001-1050)
None present or none present in regulated quantities.
CERCLA Hazardous Substance List (40 CFR 302.4):
Chemical Identity Reportable quantity Phosphoric acid 5000 lbs.
Superfund Amendments and Reauthorization Act of 1986 (SARA)
Hazard categories
Corrosive to metals Acute toxicity Skin Corrosion/Irritation Serious Eye Damage/Eye Irritation Specific Target Organ Toxicity - Single Exposure
SARA 302 Extremely Hazardous Substance
None present or none present in regulated quantities.
SARA 304 Emergency Release Notification Chemical Identity Reportable quantity Phosphoric acid 5000 lbs.
SARA 311/312 Hazardous Chemical Chemical Identity Threshold Planning Quantity Phosphoric acid 10000 lbs.
SARA 313 (TRI Reporting) None present or none present in regulated quantities.
Clean Air Act (CAA) Section 112(r) Accidental Release Prevention (40 CFR 68.130):
None present or none present in regulated quantities. Clean Water Act Section 311 Hazardous Substances (40 CFR 117.3):
Chemical Identity Reportable quantity Phosphoric acid Reportable quantity: 5000 lbs.
US State Regulations
Version: 1.3 Revision Date: 12-01-2017
SDS_US - SDSMIX000331 10/11
US. California Proposition 65 No ingredient regulated by CA Prop 65 present.
US. New Jersey Worker and Community Right-to-Know Act
Chemical Identity Phosphoric acid
US. Massachusetts RTK - Substance List
Chemical Identity Phosphoric acid
US. Pennsylvania RTK - Hazardous Substances
Chemical Identity Phosphoric acid
US. Rhode Island RTK
Chemical Identity Phosphoric acid
International regulations
Montreal protocol
not applicable
Stockholm convention
not applicable
Rotterdam convention
not applicable
Kyoto protocol not applicable
Inventory Status:
Australia AICS: On or in compliance with the inventory Canada DSL Inventory List: On or in compliance with the inventory EINECS, ELINCS or NLP: On or in compliance with the inventory Japan (ENCS) List: On or in compliance with the inventory Korea Existing Chemicals Inv. (KECI): On or in compliance with the inventory Philippines PICCS: On or in compliance with the inventory US TSCA Inventory: On or in compliance with the inventory New Zealand Inventory of Chemicals: On or in compliance with the inventory China Inv. Existing Chemical Substances: On or in compliance with the inventory Mexico INSQ: On or in compliance with the inventory Taiwan Chemical Substance Inventory: On or in compliance with the inventory
16.Other information, including date of preparation or last revision
Version: 1.3 Revision Date: 12-01-2017
SDS_US - SDSMIX000331 11/11
0
1
3
NFPA Hazard ID
Flammability
Health
Reactivity
Special hazard.
Hazard rating: 0 - Minimal; 1 - Slight; 2 - Moderate; 3 - Serious; 4 - Severe; RNP - Rating not possible
Issue Date: 12-01-2017
Revision Information: Not relevant.
Version #: 1.3
Further Information: No data available.
Disclaimer: The information provided in this Safety Data Sheet (SDS) was prepared based on data believed to be accurate as of the date of this SDS. TO THE GREATEST EXTENT PERMITTED BY LAW, AVANTOR PERFORMANCE MATERIALS (“AVANTOR”) EXPRESSLY DISCLAIMS ANY AND ALL REPRESENTATIONS AND WARRANTIES REGARDING THE INFORMATION CONTAINED HEREIN INCLUDING, WITHOUT LIMITATION, AS TO ACCURACY, COMPLETENESS, FITNESS FOR PURPOSE OR USE, MERCHANTABILITY, NON-INFRINGEMENT, PERFORMANCE, SAFETY, SUITABILITY AND STABILITY. This SDS is intended as a guide to the appropriate use, handling, storage and disposal of the product to which it relates by properly trained personnel, and is not intended to be comprehensive. Users of Avantor’s products are advised to perform their own tests and to exercise their own judgment to determine the safety, suitability and appropriate use, handling, storage and disposal of each product and product combination for their own purposes and uses. TO THE GREATEST EXTENT PERMITTED BY LAW, AVANTOR DISCLAIMS LIABILITY FOR, AND BY USING AVANTOR’S PRODUCTS PURCHASER AGREES THAT UNDER NO CIRCUMSTANCES SHALL AVANTOR BE LIABLE FOR, SPECIAL, INDIRECT, INCIDENTAL , PUNITIVE OR CONSEQUENTIAL DAMAGES OF ANY TYPE OR KIND, INCLUDING WITHOUT LIMITATION, FOR LOSS OF PROFITS, REPUTATIONAL DAMAGE, PRODUCT RECALL OR BUSINESS INTERRUPTION.