lethbri dge researc her makes a scientific breakthrough...

10/20/2017 Lethbridge researcher makes a scientific breakthrough after his son’s seizure | Metro Calgary

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Lethbridge researcher makes ascientific breakthrough after hisson’s seizureDr. Artur Luczak began studying epilepsy at the University of Lethbridge after his infantson suffered a seizure and has emerged, four years later, with a new discovery

TREVOR KENNEY / COURTESY

Dr. Artur Luczak, a researcher in the University of Lethbridge, began studying epilepsy after hisinfant son had a seizure four years ago.

By: Jennifer Friesen Metro Published on Fri Oct 20 2017

It was the middle of the night when Dr. Artur Luczak discovered that his infant son wassuffering from a seizure.

“Such things are the worst moments in someone’s life,” he said. “I work inneuroscience, so I knew about seizures and have seen them happen, but when it’syour own child who’s unconscious and jerking…it’s really something different.”

Fortunately, Luczak’s son is a now healthy four-year-old who suffered his seizure as aresult of a fever. But, even years later, the effects of the experience have lived onthrough his new scientific discovery.

Luczak, a neuroscientist at the University of Lethbridge, was already studying the basicproperties of the brain, but after witnessing his son’s seizure he turned his eye towardunderstanding epilepsy.

“(My son) will probably be free of epilepsy,” he said. “But, nevertheless, that was a bigmoment for me to decide that I should start doing some research in this area, because Ican contribute to it.”

Luczak explained that the two types of neurons in the brain, excitatory and inhibitory,play a large part in seizures. Comparing it to a car, Luczak said the excitatory neurons

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are the accelerator and the inhibitory neurons are the brakes, and the two work tobalance one another to keep the brain moving at the right speed.

It’s been widely believed that in influx of excitatory neurons are at the root of the cause,but through a collaborative study with U of L’s Dr. Bruce McNaughton and StanfordUniversity, Luczak has found that this isn’t the whole story.

“By looking more closely at the cells, we found that a surprisingly large contribution tothe brain activity during a seizure is from the inhibitor (neurons),” he said. “This tells usthat things are much more complicated than we thought.”

Although the research may not provide any quick answers on how to treat epilepsy,Luczak said it now opens new doors to understanding how seizures work.

“We want to know how these seizures are hijacking regular brain activity,” he said. “AndI think this is putting us on a better path.”

The study was recently published in the neurology journal Brain, and Luczak is alreadylooking at how to advance this new discovery.

“It’s not a ‘eureka’ moment,” he said. “It was a lot of work, but in the end it paid offbecause we found something that other people didn’t know before and that opens somany possibilities of testing different treatments.”

Luczak said that epilepsy is a complicated disorder, and that there’s plenty left todiscover, but the next step is to manipulate activity on the inhibitory neurons (thebrakes, if you will). He said he hopes a pharmacological treatment could be created tokeep others from experiencing the same fear he had while he held his son’sunconscious body in his arms four years ago.

“It’s something every father would like to avoid, having this inspiration, but ithappened,” he said. “And I stated to do something about it.”

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