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Bio3200: Human Physiology F2010

3 credits MW3-4:20pmGen Lectures 100

Mark F.A. VanBerkum5178 Biological Sciences Building577-5554

mvb@wayne.edu

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Description and Objective: To understand the basic principles of humanphysiology. Major organ systems will be covered emphasizing the structure andfunction AND regulation = PHYSIOLOGY

Basic cell biology & biochemistry very helpful reviewed in first few chapters.Represent baseline knowledge you are expected to have via prerequisites =Bio1510/2600.

Bio2600

Bio3100*

Bio1510

Bio32000

Bio3070*

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Text:

The text is REQUIRED reading.

students are responsible for ALL materialeven if NOT specifically covered in class.

The text chosen is: Human Physiology: AnIntegrated Approach with Interactive

Physiology, Fifth Edition by Dee UnglaubSilverthorn [IBSN: 0321559398].

Fourth edition: Ok I think BUT no guarantee

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Communication:

Office hours: M & W: 1:30 to 2:30 pmT 1-2 pm [ but NOT always]

You may also e-mail for a mutually convenient appointment.answer only an ODD question or two via e-mail; if complicated find meI do NOT reply to notes repeating announcements or found on BB

Class Web Site: Go to Pipeline and Blackboard [http://blackboard.wayne.edu/]to access the class web site for most class handouts (syllabus, lecture notesetc), which will be available as PDF files.

CHECK this site often, as I will try to upload a PDF file of my PowerPoint slidesbefore each class.

I also anticipate using an overhead or tablet so come prepared to take notes.

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Attendance: Class attendance is mandatory for an exam day (see datesbelow): failure to write an exam results in a zero (0). I strongly recommend

that you attend all classes to augment your own reading of the text and tocatch a glimpse of how I think/emphasize selected topics.

Timeliness: On exams dates do NOT arrive late!! You will not be allowed totake the exam if you arrive after the first student has finished the exam and leftthe room (and some students finish in less than 15 min). Assuming you sit for the exam, no additional time will be provided.

Religious Conflicts: Tell me NOW i.e. by Sept. 8, 2010i.e. look at ALL exam dates now. No make-up exams will be given unless youhave notified me in writing by the above date.

ADD/DROP POLICY : I follow all university policies on adding or dropping this

class. Contact Mrs. Hunter, Biology Advisor for help in this area.

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Individuals with Disabilities: Register with Student Disability Services (SDS)for coordination of your academic accommodations, then co-ordinate with me.

UNEXPECTED UNIVERSITY CLOSURES: will hear via:1. the University Newsline (313) 577-5345 *2. WSU Homepage ( www.wayne.edu ) *3. WSU Pipeline ( www.pipeline.wayne.edu ) *4. WDET-FM (Public Radio 101.9)5. by other local radio and television stations

If the University is officially closed on an exam day , the exam will be held on thenext regularly scheduled class day.

Any specific issue not covered by this syllabus will be resolved using Universitypolicies.

Disputes that cannot be resolved following the guidelines present in this syllabus willbe resolved by following the guidelines of the University Student Due Process.

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GRADING:4 class exams, and a cumulative final exam. Plus25 bonus clicker pointsEXAM DATES: will NOT change, content may

NO MAKE-UP EXAMS will be given as you droplowest, if dont write = zero

multiple choice with problem solving and reasoning.

Old exams on Blackboard, NOT section 3

EXAM DATES:

Wed. Sept. 22, 2010Mon. Oct. 18, 2010Wed. Nov. 10, 2010Mon. Dec. 6, 2010

Final : FRIDAY Dec.17, 2010 AT 1:20 pmThe FINAL Exam is CUMULATIVE, worth 200 points

scheduled FRIDAY Dec. 17 starting at 1:20 am (NOTE TIME AND DAY).DO NOT be late, as no extra time is provided.

Make-up exam: REQUIRE documented reason (e.g. illness, or family emergency)signed by a non-family professional person (e.g. doctor, police officer, funeral director etc.):

travel plans will NOT be used as a reason to take a make up.Without a note you do NOT write a make up AND you get a zero

a make-up exam may not occur until January.

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Grade Calculation:A letter grade is calculated after total score normalized(averaged) to the score of the second higheststudent.

This number converted to percentage and assigned aletter grade according to the table at right.

Exam I 100 points top 3 scoresExam II 100 points = 300 pointsExam III 100 pointsExam IV 100 pointsFinal Ex = 200 points

TOTAL = 500 points+ clicker bonus points 25

93-100% A

90-92 A-86-89 B+82-85 B80-81 B-76-79 C+72-75 C70-71 C-67-69 D+63-66 D60-62 D-59 or less F

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Clicker Bonus Points:

starts for points AFTER Exam 1 (although Qs will beused sooner)

25 points for voluntary/optional useadded to exam scoresif answer 90% of all questions asked = 25 points, pro-rated accordingly

ONLY accept answers received by my computer because you are here.

If I see multiple clickers in use all will be confiscated and returned to students during office hours ALL

students involved will LOSE any chance for bonuspoints and any funds spent on getting them.

Questions?

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Physiology= INTEGRATION & Homeostasis between body systems

Internal and External environments.

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Figure 1-4

It is ALL about homeostasis

Input Signal

Controller

OutputSignal

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Figure 1-5b

Concept Mapping = FlowCharts

allows you to create a basicstructure that lets you hangthe details onto

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Table 1-2

Read & understand the section on graphs and how to read them (i.e. convertthem into a sentence describing the relationship between dependent andindependent variables -- the text is full of them!

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Cell Communication: Recap from 2600Signal Transduction - conversion of one type of signal to another

ions

+ a fifth one - autocrine --self-regulation, feedback toself

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Figure 6-2 - Overview

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Figure 6-1 - Overview

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Signal transduction:conversion of an extracellular signalto intracellular signal

ligand

2600:

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Figure 6-4 (2 of 3)

In Bio2600: we usedconcept of

hydrophilic(= lipophobic)

vs

hydrophobic(= lipophilic)

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Figure 6-5

general types of membrane receptors:

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Figure 6-6

2600

review Protein Kinase A and C cascades

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KINETICS: degrees of specificity saturation maximum conductance rate

regulated (gated) inhibitable (biologically &/or

pharmacologically)

Agonist and Antagonists

Ligand-Receptor interaction: key communication step

see pgs. 40-45 for reviewon protein interactionsand kinetics

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Figure 6-10

Tyrosine kinase signaling

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Figure 6-19

Homeostasis: maintain a relatively stable environment

need to detect environment, assess if OK from either direction, and havemechanism to fix

= variety of CONTROL SYSTEMS

Canons Postulates:

1. nervous system plays role inorganism fitness

2. tonic control is often used

- set at a mid-point so can go UP & DOWN

3. Antagonistic control -- positive and

negative feedback loops regulateactivity

4. ligand and receptor specificity

endocrine one hormone,many receptors = differential response

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Figure 6-23

Control mechanism two phases:

Response loop: Afferent

and

Feedback loop: Efferent

integration

center

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tonic control of blood vesseldiameter

Antagonist control of heart rate

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Figure 6-22

Homeostasis:Multiple levels of control LOCAL vs Reflex control:

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means body must integrate information

and often it oscillates near a set point but not exactly on it asyou get feedback fromboth sides of the set point. (over shoot/undershoot)

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Control systems

vary in specificity, speed and duration

simple to complex, mixed endocrine & neuronal loops every connection point is an integration point

(i.e. cell has to make a decision to do something or not)

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Figure 6-31 - Overview

as we cover chp 7think about thesechain of events