january 25, 2014 john f. la disa, jr., ph.d....

January 25, 2014

JOHN F. LA DISA, JR., Ph.D.

CURRICULUM VITAE Present Positions: Associate Professor with Tenure - Marquette University,

Department of Biomedical Engineering

Director - Laboratory for Translational, Experimental and Computational Cardiovascular Research (CV T.E.C. Lab)

Director - Marquette University Visualization Laboratory

Adjunct Faculty - Children's Hospital of Wisconsin, Department of Pediatrics

Adjunct Professor of Medicine - Medical College of Wisconsin, Department of Cardiovascular Medicine

Address: Marquette University Engineering Hall, Room 311 1637 West Wisconsin Avenue Milwaukee, WI 53233

Telephone: 414- 288-6739

Facsimile: 414- 288-7938

Electronic Mail: [email protected]

Websites: http://www.eng.mu.edu/cvtec/ http://www.eng.mu.edu/vizlab/ EDUCATION AND TRAINING

Postdoctoral Scholar, Pediatric Cardiology, Stanford University, CA, 2004-2006 Ph.D., Biomedical Engineering, Marquette University, Milwaukee, WI, 2004 M.S., Biomedical Engineering, Marquette University, Milwaukee, WI, 2001 B.S., Biomechanical Engineering, Marquette University, Milwaukee, WI, 2000

RESEARCH AND PROFESSIONAL EXPERIENCE

Assistant Professor of Biomedical Engineering - Marquette University, Milwaukee WI 2007-2013

Postdoctoral Scholar - Department of Pediatrics, Division of Pediatric Cardiology, Stanford University, Stanford, CA, 2004-2006

Research Technician - Department of Anesthesiology Research, Medical College of Wisconsin, Milwaukee, WI, 2001-2004

Laboratory Assistant - Department of Anesthesiology Research, Medical College of Wisconsin, Milwaukee, WI, 1998-2001

Research and Development & Quality Assurance Cooperative Education Student - Boston Scientific Corporation, Maple Grove, MN, 1997-99

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AWARDS AND HONORS

Received since accepting faculty position at Marquette University 2012 Editor's Choice list (1 of 9 papers) for Optimization of cardiovascular stent

design using computational fluid dynamics by TJ Gundert, AL Marsden, W Yang, JF LaDisa, Jr. J Biomech Eng 2012 Jan;134(1):011002

2012-13 e-learning Faculty Fellowship - Marquette University Center for Teaching and Learning. January 1, 2013 - December 31, 2013

Young Engineer of the Year Award - STEM Forward (formerly Engineers & Scientists of Milwaukee), February 16, 2012

Rising Star Award - Marquette Chapter of Sigma Xi, April 7, 2010 Featured in Milwaukee Magazine’s The Next Generation: New leaders under 40 who

will change Milwaukee. January 2009. Best Technology Business Plan Award Winner - 6th Annual Kohler Center for

Entrepreneurship Business Plan Competition, Marquette University, April 2008

Received prior to accepting faculty position at Marquette University 3rd Place - 2nd Annual Governor’s Business Plan Contest (Biomedical Sciences

Division), Wisconsin Technology Council, June 2005 Grand Prize, Alumni and Vox Populi Award Winners - 3rd Annual Kohler Center for

Entrepreneurship Business Plan Competition, Marquette University, April 2005 NSF Fellow - International Summer School on Biocomplexity from System to Gene,

Dartmouth College, July 19-25, 2003 Caroline tum Suden/Francis Hellebrandt Professional Opportunity Award - American

Physiological Society, January 2003 Student Travel Award - Biomedical Engineering Society, October 2002 Alpha Sigma Nu Graduate Student Scholarship - Marquette University, July 2001 Graduate Student Industrial Fellowship, Boston Scientific Corporation, June 2000 Alpha Eta Mu Beta - National Biomedical Engineering Honor Society, Marquette

University, 2000 Pi Mu Epsilon - National Mathematics Honor Society, Marquette University, 1999 Alpha Sigma Nu - National Jesuit Honor Society, Marquette University, 1999 Engineering Deans List - fall ‘96, spring ‘97, spring ‘98, fall ’98, spring ’99, spring ’00,

fall ’01, and fall ’02. ACADEMIC SERVICE AND PROFESSIONAL ACTIVITIES

Committees and University service: Gap Analysis Planning Committee: Kohler Center for Entrepreneurship Marquette

University, February 2012 to present - committee composed of faculty, staff, alumni and business personnel working with the Market Strategy Group on future planning efforts that highlight key gaps the center could address.

Leadership role for the Discovery Learning Complex Visualization facility, 2010 to present - Identifying pertinent applications, required hardware and software, and usage policies for potential users throughout the Marquette community

Core Evaluation Committee for the Clinical and Translational Science Institute (CTSI), 2011 - committee comprised of directors, users, and representatives of research groups, departments, and centers CTSI-affiliated institutions that

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evaluates performance, monitors usage, and make recommendations to the oversight advisory committee regarding expansion or discontinuation of cores.

College of Engineering Opus Dean Search Committee Member, 2009-10

Student Advising - curriculum guidance for ~ 10-12 students each semester

Undergraduate Committee - Dept. of Biomedical Engineering, 2008 - present

Senior Design Team Mentor Fall 2007 - B18: Medication Scheduling System Fall 2008 & Spring 2009 - B16: Medication Spinal Rod Cutter Fall 2009 & Spring 2010 - B13: Laparoscopic Surgery Simulator Fall 2011 & Spring 2012 - B5: Rubber Dam Tooth Clamp for Dental Procedures Fall 2012 & Spring 2013 - B22: Automated Counting System for the Operating Room Fall 2013 & Spring 2014 - B31: Low Cost Ventriloscope

Memberships in professional societies: American Physiological Society (#44909) American Society of Mechanical Engineers - Bioengineering Division (#7818651) Biomedical Engineering Society (#5619) IEEE Division of Engineering in Medicine and Biology Society (#41527494) Society for Experimental Biology and Medicine (#22622) Sigma Xi Scientific Research Society

Peer-reviewed journal affiliations:

Associate Editor - ASME Journal of Medical Devices, 8/1/2013 - 8/1/2016 Frontiers in Pediatric Cardiology - Review Editorial Board Member, 2012 - present Ad-hoc journal reviewer: AJP-Heart Circ Physiol, Anesthesiology, Annals of

Biomedical Engineering, BioMedical Engineering OnLine, Cardiovasc and Intervent Radiol, Circulation, J Applied Physiol, J Biomechanics.

Health Research Board in Ireland - grant reviewer 2005 McGill Journal of Medicine - Junior Editor, 2002-2003

Invited scientific service:

Consultant - Expert analysis and witness to conduct failure analysis on a delivery catheter that failed during use. The case settled as a result of the analysis.

Faculty member for the 2012 Lifeline Vascular Access - Physician Operators Forum, Denver, April 2012

Session Chair - Annual Meeting of the Biomedical Engineering Society: Systems Biology, Bioinformatics & Computational Bioengineering, Hartford, October 2011

Session Chair - ASME Bioengineering Division, Summer Bioengineering Conference: CFD Modeling, Farmington, June 2011

American Heart Association Peer Reviewer - 2011 - present Session Chair - ASME Bioengineering Division, Summer Bioengineering

Conference: Cardiovascular Design and Devices I, Naples, June 2010 Program Committee Member & Session Chair - SPIE Medical Imaging: Biomedical

Applications in Molecular, Structural & Functional Imaging, San Diego 2010 Member of Fluids Committee - ASME Bioengineering Division, Summer

Bioengineering Conference, 2009 - present

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Faculty member for the 2008 IMAGING & PHYSIOLOGY Summit - sponsored by the CardioVascular Research Foundation (CVRF), Seoul, Korea, November 2008

TEACHING

Since accepting faculty position at Marquette University Instructor for BIEN 4720/5720 (formerly BIEN183): Cardiopulmonary Mechanics -

Spring, 2007, 2008, 2009, 2011 and Fall 2012, 2013 Co-Instructor for BIEN1100 (formerly BIEN002): Introduction to Biomedical

Engineering Methods 2 - Spring, 2007 - 2013 Instructor for BIEN4400/5400 (formerly BIEN186): Transport Phenomena for

Biomedical Engineers - Fall 2007 - 2012, 2013 and Spring 2010, 2012, 2014 Instructor for BIEN210: Biofluid Mechanics - Fall, 2008

Prior to accepting faculty position at Marquette University Co-Instructor for BIOE284A/ME284A: Cardiovascular Bioengineering - Stanford

University, Stanford, CA, Autumn, 2005 and Autumn, 2006 Course Moderator and Administrator for BIOE390/MED289: Introduction to

Bioengineering Research - Stanford University, CA, Autumn, 2005 and Fall 2006 Choice Instructor and creator of “How the Body Works” - De Marillac Middle School,

San Francisco, CA, 2005 Guest Lecturer for Physiology, Media College Prep High School, Oakland, CA, 2005

RESEARCH MENTORSHIP, THESIS AND DISSERTATION COMMITTEES

Mentees since accepting faculty position at Marquette University:

Undergraduate Research Mentor: William Wang (B.S. in Biomedical Engineering 2013 - Marquette University) Mia Helfrich (B.S. in Biomedical Engineering 2013 - Brown University) Michael Kamykowski (B.S. in Biomedical Engineering 2014 - Marquette University) Daphne Gutierrez (B.S. in Biomedical Engineering 2015 - Marquette University) Keelia Doyle (B.S. in Biomedical Engineering 2015 - Marquette University)

NSF Fellow - 12th International Summer School on Biocomplexity and Biodesign: from Gene to System, June 23-9, 2013 Istanbul, Turkey

Master's Thesis Chair and Primary Advisor:

Andrew Williams M.S. (B.S. in Biomedical Engineering from Marquette University), Quantifying Hemodynamic Changes Caused by Stenting of Coronary Bifurcation Lesions Using Realistic Computational Fluid Dynamics Models. December 2008

BS/MS student in Biomedical Engineering at Marquette University

Participant for the 2007 Emerging Entrepreneurs in Biomedical Technology Workshop - Stanford University, October 5-6, 2007

currently a Mechanical Design Engineer with Creation Technologies

Ronak Dholakia M.S. (B.S. in Biomedical Engineering from University of Mumbai), Numerical Modeling of Hemodynamics in the Thoracic Aorta and Alterations by Dacron Patch Treatment of Aortic Coarctation. December 2009

currently a PhD student and Research Specialist with the Cerebrovascular Research Center at Stony Brook University Medical Center

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Sara Nomeland M.S. (B.S. in Biomedical Engineering from Michigan Tech), Image-based quantification workflow for coronary morphology: a tool for use in next-generation bifurcation stent design. August 2010

Recipient of the 2009 Maurice L. Madden Biomedical Engineering Fellowship

currently an Engineer with MED Institute, Inc. (Cook Medical)

Timothy Gundert M.S. (B.S. in Biomedical Engineering May 2009), Improving cardiovascular stent design using patient-specific models and shape optimization. December 2011


Awarded 3rd Place in the Bachelor's Student Paper Competition of the ASME Summer Bioengineering Conference (Biotransport, Tissue Engineering, and Cellular Biomechanics Category): Presented at the Resort at Squaw Creek Lake Tahoe, CA June 17-21, 2009

Awarded 2nd Place in the Master’s Student Paper Competition of the ASME Summer Bioengineering Conference (Solid Mechanics, Design and Rehabilitation Engineering Category): Presented at the Grande Beach Resort, Naples, FL June 16-19, 2010

MAGS Distinguished Master's Thesis Award nominee for Marquette University

currently a R&D Engineer at Medtronic - Renal Denervation (F/K/A Ardian)

David 'DJ' Quam M.S. (B.S. in Biomedical Engineering May 2009), Advanced visualization and intuitive user interface systems for biomedical applications. May 2012


accepted an Engineer position as part of the Quality/Regulatory Leadership Program at GE Healthcare

Sung Kwon (B.S. in Biomedical Engineering from the University of Minnesota), Quantification of local hemodynamic alterations caused by virtual implantation of three commercially-available stents for the treatment of aortic coarctation. December 2013

accepted a Quality Engineer position at Baxter Healthcare

Joshua Hughey (B.S. in Biomedical Engineering from the University of Missouri), 2012 - present

Ali Aleiou (B.S. in Biomedical Engineering from the University of Minnesota), 2012 - present

Daniel Greenheck (B.S. in Biomedical Engineering from the University of Wisconsin - Madison), August - December 2013

Doctoral Dissertation Primary Advisor: Dave Wendell (B.S. in Electrical Engineering from Purdue University), Incorporating

the Aortic Valve into Computational Fluid Dynamics Models Using Phase-Contrast MRI and Valve Tracking. December 2011

Recipient of an American Heart Association Predoctoral Fellowship - Greater Midwest Affiliate

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currently a Postdoctoral Scholar at the Duke Cardiovascular Magnetic Resonance Center (DCMRC) of Duke University Medical Center PIs: Raymond Kim, MD and Robert Judd, PhD

Arjun Menon (B.S. in Biomedical Engineering from the University of Minnesota), Quantifying the impact of altered hemodynamics and vascular biomechanics to changes in structure and function in native and corrected aortic coarctation.

May 2012

currently a Postdoctoral Scholar in the Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine PI: Edward A. Fisher, PhD, MD, MPH

Hongfeng 'Nick' Wang (Doctor of Veterinary Medicine and M.S. in Embryonic Engineering, Northwest A&F University, China, M.S. in Genetics, Mississippi State University), Vascular changes in Type 2 Diabetes Mellitus: application to restenosis to restenosis after stenting

May 2013

Recipient of the Chinese Government Award for Outstanding Students Abroad by China's Scholarship Council

Recipient of an Arthur J. Schmitt Fellowship Award

Thomas Dienhart (B.S. in Biomedical Engineering from Michigan Tech), 2012 - 2013

Awarded 3rd Place in the Graduate Division of the Sigma Xi 2013 Student Research Showcase (Engineering Section)

Applicant for an American Heart Association Predoctoral Fellowship - Greater Midwest Affiliate

Scott Loberg (B.S. in Biology from Winona State University) August - December 2013

Benjamin R. Dickerhoff (B.S. & M.S. in Biomedical Engineering from the University of Iowa)

December 2013 - present

M.S. Thesis advisor - Madhavan Raghavan Ph.D. - University of Iowa

Doctoral Dissertation Committee Member: John A. Wheeldon BSEE MSEE, The Role of Mechanical Changes in the Aging

Cervical Spine, defended November 2008

Jason J. Hallman, Detrimental Thoracoabdominal Interaction with Llateral Airbag Restraints, completed December 2010

Zhuohui Gan, Quantitative Evaluation of Redox Processes in the Intact Rat Lung and Cultured Pulmonary Artery Endothelial Cells and the Effect of Hyperoxia, completed December 2011

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Postdoctoral Scholars: Laura Ellwein, Ph.D. (B.S. in Chemical Engineering from University of Wisconsin -

Madison; Ph.D. in the Interdisciplinary Physiology Concentration of Applied Math at North Carolina State University; Thesis advisor: Mette S. Olufsen, Ph.D.)

2009-2012

Recipient of an American Heart Association Postdoctoral Fellowship - Greater Midwest Affiliate

currently an Assistant Professor of Mathematics (tenure-track) at Virginia Commonwealth University

Mentees prior to accepting faculty position at Marquette University: Paul Larsen (Medical Student, Tulane School of Medicine, B.S. from Washington

University in St. Louis, 2007) Nicholas Telischak (Medical Student, Dartmouth Medical School, 2007) Dominic Lai (Undergraduate Student, Biomedical Sciences, Marquette University,

2004, currently a Pharmacy resident) Dunbar Alcinor (Medical Student, Medical College of Wisconsin, 2002-03, currently

Neurosurgery Resident at Alleghany General Hospital in Pittsburgh, PA) Eric Kersten (Undergraduate Student, Biomedical Engineering, Northwestern

University, 2002, currently an Engineer with GE Medical Systems) Ankit Shah (Graduate Student, Biomedical Engineering, Marquette University, 2002, currently a Wharton MBA student - University of Pennsylvania)

GRANTS AND CONTRACTS Funding to date: direct costs (DC): $1,150,456; with indirect costs (wIDC): $1,362,996 Percent effort indicated after the role for each grant.

Received since accepting faculty position at Marquette University: Marquette University Center for Teaching and Learning “IDIVE, an integrated digital

immersive virtual environment for enhancing engineering education”. 2012-13 e-learning Faculty Fellowship DC: N/A 1/1/13-12/31/13 Role: PI (1.8 cal)

Children's Hospital of Wisconsin, "Next-generation visualization of data and CFD results". Educational Research Agreement

DC: $20,770 wIDC: $28,345 1/ 1/12-8/31/13 Role: PI (as needed)

Marquette University College of Engineering Summer Undergraduate Research Program, “Optimizing flow patterns over vascular cells: reducing cellular proliferation for application to drug eluting stents”

DC: $3,000 5/27/13-8/9/13 Role: PI (as needed)

NIH, “Cardiovascular, Lung, and Blood Computation Model Library”. Contract to Open Source Medical Software Corporation DC: $83,584 wIDC:$117,353 5/30/11-5/29/13 Role: Co-I(2 summer mo) N Wilson (PI)

Marquette University Office of the Provost, “The Use of the IDIVE - An Integrated Digital Immersive Virtual Environment to Facilitate Nursing Student

Development of Clinical Reasoning”. Assessment Mini-Grants DC: $2,500 1/1/12-6/30/12 Role: Co-I(as needed) K Goepfert(PI)

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NIH, “Quantifying altered hemodynamics in response to stenting for aortic coarctation”. R15 - Academic Research Enhancement Award

DC: $158,936 wIDC:$241,420 4/1/09-4/30/12 Role: PI (1 summer mo)

Medical College of Wisconsin, “CFD Modeling for Pediatric Cardiovascular Disease”. Contract through Margaret Samyn MD.


American Diabetes Association, “A novel interdisciplinary approach to characterize and minimize vascular changes contributing to restenosis after stenting in type 2 diabetes mellitus” Junior Faculty Award

DC: $357,609 wIDC:$411,251 7/1/08-6/30/11 Role: PI (2.4 cal + 2 summer mo)

CTSI of Southeastern Wisconsin, “Computational Cardiology: Translating theoretical and subject-specific computational fluid dynamics results into a specialized stent for coronary artery bifurcation lesions” Translational Opportunity Grant of the Pilot and Collaborative Clinical and Translational Research Grants program


Medtronic Corporation, “CFD Stent Analysis”. Educational Research Agreement. DC: $8,316 wIDC $12,516 8/1/10-9/30/10 Role: PI (as needed)

Alvin & Marion Birnschein Foundation, “A coupled clinical and computational approach to determine important design characteristics of a novel stent specifically designed for the progressive treatment of aortic coarctation”


NIH, “A novel cardiovascular stent for the intrinsic reduction of restenosis and thrombus formation”, Small Business Technology Transfer (STTR) Award - R41

DC: $99,983 8/1/08-7/31/09 Role: PI (Vascular Prolifix, LLC; N/A)

Biomedical Engineering Research Initiative for Undergraduate Students, “Developing Cardiovascular Content for the Discovery World HIVE Visualization Facility”


Committee on Research Summer Faculty Fellowship and Regular Research Grant Programs, “Engineering a novel treatment for the reduction of long-term morbidity in children with aortic coarctation”.

DC: $11,500 7/01/08-12/31/08 Role: PI (0.75 summer mo)

Children’s Research Institute “Cardiac Magnetic Resonance Imaging (cMRI) Assessment of Early Atherosclerosis in Pediatric Type I Diabetic (T1DM), Type 2 Diabetic (T2DM) and Metabolic Syndrome Patients”

DC: $74,864 1/01/08-12/31/08 Role: Co-I (as needed), M Samyn (PI)

Alvin & Marion Birnschein Foundation, “A coupled clinical and computational approach to determine important design characteristics of a novel stent specifically designed for the progressive treatment of aortic coarctation”


Marquette University College of Engineering Research Incentive Program, “Computational assessment of adverse hemodynamic alterations and subsequent

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restenosis caused by changes in distal resistance resulting from type II diabetes mellitus” DC: $8,357 1/01/08-6/30/08 Role: PI (as needed)

NIH, “Patient-specific computational modeling of altered hemodynamics, arterial deformation and morbidity induced by aortic coarctation and subsequent surgical or catheter-based repair”. Loan Repayment Programs

DC: $8,037 7/1/06-6/30/08 Role: PI (N/A)

Biomedical Engineering Research Initiative for Undergraduate Students, “Development of a phantom and offline postprocessing techniques for use with 3D ultrasound data of the human carotid bifurcation”

DC: $2,000 1/01/08-5/31/08 Role: co-PI w T. Gilat-Schmidt (N/A)

Current: Kobe University School of Medicine, "Optical coherence and computed tomography

for evaluation of wall shear stress and thrombus potential in coronary arteries after stenting". Educational Research Agreement

DC: 61,130 wIDC: $92,000 8/27/12-8/26/14 Role: PI (as needed)

Pending: Marquette University College of Engineering Summer Undergraduate Research

Program, “Visualization lab content creation and implementation” DC: $5,000 5/26/14-8/8/14 Role: PI (as needed)

Marquette University College of Engineering Summer Undergraduate Research Program, “Characterizing brain activity in response to driving task complexity in an immersive virtual reality environment”

DC: $5,000 dates: TBD Role: Co-I (as needed) Drakopoulos & Beardsley (PIs)

Marquette University College of Engineering Summer Undergraduate Research Program, “Landslide hazards as a result of deforestation and heavy rain conditions in South American regions”

DC: $5,000 dates: TBD Role: Co-I (as needed) T Lin (PI)

NSF/Southern California Earthquake Center, “Visualizing emergency response under extreme motions”

DC: $22,166 wIDC:$34,972 2/1/14-1/31/15 Role: Co-I (as needed) T Lin (PI)

NIH, “Optimizing mechanical stimuli around stents to reduce restenosis and thrombosis”. R01 - Research Project Grant

DC: $ 1,281,319 wIDC:$1,885,549 7/1/14-6/30/19 Role: PI (1.8 cal + 2 summer mo)

Marquette University College of Engineering (CoE), "Proposal for the purchase of an ILUMIEN optical coherence tomography (OCT) and pressure measurement system" CoE RFP for Research Equipment

DC: $156,485 Role: PI

NIH, “Impact of native and treated aortic coarctation on vessel structure and function”. R15 - Academic Research Enhancement Award resubmission


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Unfunded: Alvin & Marion Birnschein Foundation, “Optimizing local blood flow patterns

surrounding stents to reduce restenosis and thrombosis” DC: $20,000 1/1/14-12/31/14 Role: PI (as needed)

Leducq Foundation, “FORECAST project: FORsee clinical outcomEs in CoronAy bifurcation STenting: biomechanics meets imaging”. Transatlantic Networks of Excellence Program in Cardiovascular Research project

Letter of Intent submitted for consideration of full proposal Role: North American Coordinator (2.0 cal)

FDA, “MedDev4kids: A Midwest-based Nationwide Pediatric Device Consortium”. P50 - Pediatric Device Consortia Program

DC: $3,581,819 wIDC:$3,745,000 9/1/13-8/31/18 Role: Co-PI (2.0 cal + 2 summer mo), J Winters (PI)

NIH, “Impact of native and treated aortic coarctation on vessel structure and function”. R15 - Academic Research Enhancement Award


Saving tiny Hearts Society "Extent of reversibility for coarctation-induced vascular changes after treatment"

Research Grant program DC: $74,290 1/1/13-12/31/13 Role: PI (1.5 summer mo)

Alvin & Marion Birnschein Foundation, “Stereoscopic visualization system with intuitive gesture-based controls for biomedical and scientific data sets”


NIH, “IDIVE-integrated digital immersive virtual environments to advance patient safety”. R18 - Advances in Patient Safety through Simulation Research

DC:$717,436 wIDC:$1,049,942 7/1/12-6/30/15 Role: Co-I (1.8 cal) K Goepfert (PI)

Marquette University Committee on Teaching, “The Use of IDIVE: An Integrated Digital Immersive Virtual Environment to facilitate nursing student development of clinical reasoning skills that improve patient safety”.

Way-Klingler Teaching Enhancement Award wIDC: $ 20,000 7/1/12-6/30/13 Role: Co-I (as needed) K Goepfert (PI)

American Heart Association, “A novel experimental approach to identify mechanisms of morbidity in aortic coarctation” National Innovative Research Grant

wIDC: $150,000 1/1/12-12/31/13 Role: PI (1 summer mo)

NSF, “Optimizing cardiovascular stents for patient-specific atherosclerotic lesions using biofluid dynamics, drug-elution profiles and visualization of results in immersive environments amenable to informal science education.” Faculty Early Career Development CAREER

wIDC: $ 515,873 3/1/12-2/28/17 Role: PI (2 summer mo)

Saving tiny Hearts Society, "Characterizing local aortic hemodynamics for next-generation surgical optimization in patients with hypoplastic left heart syndrome."

Research Project wIDC: $30,000 8/1/10-7/31/11 Role: PI (as needed)

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NSF, “Vascular Voyage: an immersive tool for interactive teaching, learning and research.” Faculty Early Career Development CAREER

wIDC: $584,105 1/1/10-12/31/14 Role: PI (2 summer mo)

NIH, “Vascular Voyage: an Interactive and Immersive STEM Experience”. RC1 - NIH Challenge Grants in Health and Science Research

wIDC: $995,478 9/30/09-9/29/11 Role: PI (as needed)

The Children's Heart Foundation, “A coupled computer-based and experimental approach to quantify altered hemodynamics and vascular biomechanics in response to stent implantation for aortic coarctation.”

wIDC:$65,620 1/01/09-12/31/09 Role: PI (as needed)

Wallace H. Coulter Foundation, “A coupled clinical, experimental and computational approach to determine important design characteristics of a novel stent specifically designed for the progressive treatment of aortic coarctation”. Early Career Translational Research Award in Biomedical Engineering (resubmission)

wIDC: $235,972 2008-10 Role: PI (3.84 cal)

NIH, “Diabetes and restenosis: a novel integrative strategy for clinical translation”. Director's New Innovator Award Program (DP2)

wIDC: $1,888,510 09/28/07-08/31/12 Role: PI (2.4 cal + 3 summer mo)

Thrasher Pediatric Research Fund, “A coupled experimental and computational investigation to assess the safety and efficacy of isometric handgrip exercise as a way of alleviating persistent hypertension and morbidity in children previously treated for aortic coarctation.”


American Society of Echocardiography, “Use of 3D and Doppler ultrasound to generate patient-specific wall shear stress maps in carotid artery disease following statin treatment: a novel and practical way of understanding the link between structure (plaque morphology) and flow dynamics”. Echo Investigator Award


Wallace H. Coulter Foundation, “A coupled clinical, experimental and computational approach to determine important design characteristics of a novel stent specifically designed for the progressive treatment of aortic coarctation”. Early Career Translational Research Award in Biomedical Engineering

wIDC: $230,696 2007-9 Role: PI (3 cal)

Received prior to accepting faculty position at Marquette University: Stanford University, “Computational Modeling of Alterations in Vascular

Hemodynamics for Optimization of Surgical and Catheter-Based Therapies and Long-Term Outcomes in Aortic Coarctation”. Dean's postdoctoral fellowship,

DC: $40,000 2004-05 Role: PI (12 cal)

Sigma Xi Scientific Research Society, “Local Vascular Geometry and Shear Modulated Mitotic Expression After Chronic Stenting”. Grants-in-Aid of Research, dissertation project supply stipend

DC: $1,000 2003 Role: PI (N/A)

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Boston Scientific Corporation, "In Vivo and Computational Fluid Dynamics Modeling of Hemodynamic Changes Induced by Coronary Stenting” Graduate Thesis Project, tuition and stipend

DC: ~$30,000 2000-01 Role: PI ( 12 cal) PATENTS AND DISCLOSURES

Progressive expansion diameter stent, Disclosed to Stanford University April 18, 2005.

Apparatus and method for minimizing flow disturbances in a stented region of a lumen - #US20080140179, published June 12, 2008 (abandoned after second final rejection)

Gesture-based visualization system for biomedical imaging and scientific datasets, Disclosed to Marquette University/Medical College of Wisconsin July 23, 2012.

PRESENTATIONS (students and trainees indicated in boldface)

Offered since accepting faculty position at Marquette University:

National: " Recent progress in the use of experimental and computational tools to optimize flow

patterns around stents and reduce coronary artery restenosis" Department of Mechanical Engineering and Materials Science - University of Pittsburgh, October 15, 2013

"Stent architecture/design - does it matter for restenosis?" Invited presentation - Lifeline Vascular Access 2012 Physician Operators Forum, Denver, April 14, 2012

"Hemodialysis, stenosis and Chronic Kidney Disease: An Engineer's Perspective" Invited presentation - Lifeline Vascular Access 2012 Physician Operators Forum, Denver, April 14, 2012

"The Success of Aortic Arch Surgery: An Engineer's Perspective" Invited presentation - American Heart Association (AHA) Scientific Sessions 2011: Cardiovascular Seminar entitled Biomedical Engineering Insights into Congenital Heart Disease, Orlando, FL, Nov. 15, 2011

“Coupling experimental and computational tools to quantify hemodynamic alterations introduced by stents” Invited presentation - CardioVascular Innovation Seminar (CVIS) series, Medtronic CardioVascular, Santa Rosa, CA, Jan. 19, 2011

“Aortic coarctation: recent developments in experimental and computational methods to assess treatments for this simple condition.” Invited presentation - 1st International Conference on Computational Simulation in Congenital Heart Disease, San Diego, Feb. 27, 2010

“A new image-based process for quantifying hemodynamic contributions to long-term morbidity in a rabbit model of aortic coarctation” offered by DC Wendell, RJ Dholakia, PM Larsen, AR Menon, JF LaDisa, Jr. SPIE Medical Imaging: Biomedical Applications in Molecular, Structural & Functional Imaging, San Diego, Feb. 2010

“Coupling clinical and computational resources to quantify hemodynamic alterations as indices of morbidity and engineer novel treatment strategies for carotid artery

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disease”, Invited presentation - Penner Biomechanics Seminar, Department of Mechanical Engineering, University of California - San Diego, May 20, 2009

“Coupling experimental, computational and translational resources for use in next generation stent design”, Invited presentation - Abbott Vascular, Santa Clara, August 10, 2007

International: "Mircroarray analysis of changes induced by coarctation and restored upon its repair."

Invited presentation - 4th International Frontiers Conference on Pediatrics and Congenital Heart Diseases. Sponsored by Stanford University and INRIA. Paris, France. forthcoming May 2014.

"Optimization-based treatment of coronary artery bifurcation lesions following plaque characterization." Invited presentation - 9th International Symposium on Biomechanics in Vascular Biology and Cardiovascular Disease. Montreal, Canada, forthcoming April 2014.

“Combined use of imaging and computational techniques to investigate fluid dynamics in normal and stented coronary artery bifurcations” Invited presentation - IMAGING & PHYSIOLOGY Summit 2008, sponsored by the CardioVascular Research Foundation (CVRF), Seoul, Korea, November 22, 2008

Regional: "Developing immersive visualization content for interactive teaching, learning and

research" Invited presentation - MBECC 2011: Visualization in Medicine Panel, Northwestern University, Evanston, IL, April 1, 2011

Local: “Cardiac magnetic resonance imaging assessment of early atherosclerosis in

pediatric patients with Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, and Metabolic Syndrome” Invited co-presentation (with Margaret Samyn, MD) - Cardiovascular Translational Research Symposium, Clinical and Translational Research Institute (CTSI), January 9, 2009

“Leveraging current imaging techniques for next-generation medical diagnosis, monitoring and treatment” Invited presentation - Cultivating Innovation Symposium, GE Healthcare, Milwaukee, December 12, 2008

“Coupling clinical and computational resources to quantify hemodynamic alterations as indices of morbidity and engineer novel treatment strategies for carotid artery disease”, Invited presentation - Cardiology Grand Rounds, Department of Cardiovascular Medicine, Medical College of Wisconsin, February 12, 2008

Offered prior to accepting faculty position at Marquette University: “Coupling experimental and computational tools for use in next generation in stent

design”, Invited presentation - Medtronic Vascular, Santa Rosa, November 29, 2006

“Recent progress and future initiatives for quantifying hemodynamic alterations as indices of morbidity before and after repair of aortic coarctation”, Special Symposium on Aortic Coarctation, Children’s Hospital of Wisconsin, March 9, 2006

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“Patient-specific modeling of altered hemodynamics and arterial deformation induced by coarctation of the aorta and subsequent stent implantation”, poster presentation, Biomedical Computation at Stanford (BCATS) Symposium, Oct. 15, 2005

“Distributions of wall shear stress influence neointimal hyperplasia after stent implantation in vivo” Biomedical Engineering Society Annual Meeting, Oct. 2004

WHITE PAPERS

1. John F. LaDisa, Jr., with contributions by Michael S. Switzenbaum, Keith Rocheck and Brad Bonczkiewicz. Purchase Recommendations for the Visualization Laboratory in Engineering Hall - submitted to Robert H. Bishop PhD, OPUS Dean, College of Engineering, Marquette University, October 2012

2. John F. LaDisa, Jr., with contributions by Christopher M. Foley and Saeed Karshenas. Developing Interest, Content, Publicity and Expertise for an Advanced Visualization Facility - submitted to Stan Jaskolski, OPUS Dean, and Michael S. Switzenbaum, Professor and Executive Associate Dean, College of Engineering, Marquette University, August 2008

BOOK CHAPTERS

John F. LaDisa, Jr., Charles A. Taylor, Jeffrey A. Feinstein. Endovascular treatment strategies for coarctation of the aorta. In: Current Treatment of Thoracic Aortic Diseases. 2006. Editor: Herve Rousseau, Springer, pp. 363-374.

PEER-REVIEWED JOURNAL ARTICLES (students and postdocs in boldface)

Since accepting faculty position at Marquette University: 1. Sung Kwon, Jeffrey A. Feinstein, Ronak Dholakia, John F. LaDisa, Jr.

Quantification of local hemodynamic alterations caused by virtual implantation of three commercially-available stents for the treatment of aortic coarctation. Accepted to Pediatric Cardiology. DOI: 10.1007/s00246-013-0845-7

2. Timothy J. Gundert, Ronak J. Dholakia, Dennis McMahon, John F. LaDisa, Jr. Computational fluid dynamics evaluation of equivalency in hemodynamic alterations between Driver, Integrity and similar stents implanted into an idealized coronary artery. J Med Device. 2013 Mar;7:011004 doi:10.1115/1.4023413

3. Arjun Menon, Thomas J. Eddinger, Hongfeng Wang, David C. Wendell, Jeffrey M. Toth, John F. LaDisa, Jr. Altered hemodynamics, endothelial function and protein expression occur with aortic coarctation and persist following repair. Am J Physiol Heart Circ Physiol. 2012 Dec;303(11):H1304-18.

4. David C. Wendell, Margaret M. Samyn, Joseph R. Cava, Laura M. Ellwein, Mary M. Krolikowski, Kimberly L. Gandy, Andrew N. Pelech, Shawn C. Shadden, John F. LaDisa, Jr. Including aortic valve morphology in computational fluid dynamics simulations: initial findings and application to aortic coarctation. Med Eng Phys. 2013 Jun; 35(6):723-35.

5. Timothy J. Gundert, Alison L. Marsden, Weiguang Yang, David S. Marks, John F. LaDisa, Jr. Identification of hemodynamically optimal coronary stent designs based on vessel diameter. IEEE Trans Biomed Eng. 2012 July; 59(7):1992-2002.

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6. Jessica S. Coogan, Frandics P. Chan, John F. LaDisa, Jr., Charles A. Taylor, Frank L. Hanley, Jeffrey A. Feinstein. Computational fluid dynamic simulations for determination of ventricular workload in aortic arch obstructions. J Thorac Cardiovasc Surg. 2013 Feb; 145(2):489-495.e1

7. Timothy J. Gundert, Alison L. Marsden, Weiguang Yang, John F. LaDisa, Jr. Optimization of cardiovascular stent design using computational fluid dynamics. J Biomech Eng 2012 Jan;134(1):011002 doi:10.1115/1.4005542. 1 of 9 papers selected to the 2012 Editor's Choice list

8. Arjun Menon, David C. Wendell, Hongfeng Wang, Thomas J. Eddinger, Jeffrey M. Toth, Ronak J. Dholakia, Paul M. Larsen, Eric S. Jensen, John F. LaDisa, Jr. A novel coupled experimental and computational approach to quantify deleterious hemodynamics, vascular alterations, and mechanisms of long-term morbidity in response to aortic coarctation. J Pharmacol Toxicol Meth. 2012 Jan; 65(1):18-28.

9. John F. LaDisa, Jr., C. Alberto Figueroa, Irene E. Vignon-Clementel, Hyun Jin Kim, Nan Xiao, Laura M. Ellwein, Frandics P. Chan, Jeffrey A. Feinstein, Charles A. Taylor. Computational simulations for aortic coarctation: representative results from a sampling of patients. J. Biomech. Eng. 2011 Sep;133(9):091008. doi:10.1115/1.4004996. = authors contributed equally

10. John F. LaDisa, Jr., Ronak J. Dholakia, C. Alberto Figueroa, Irene E. Vignon-Clementel, Frandics P. Chan, Margaret M. Samyn, Joseph R. Cava, Charles A. Taylor, Jeffrey A. Feinstein. Computational simulations demonstrate altered wall shear stress in aortic coarctation patients previously treated by resection with end-to-end anastomosis. Congenit Heart Dis. 2011 Sep; 6(5): 432-43.

11. Laura M. Ellwein, Hiro Otake, Timothy J. Gundert, Bon-Kwon Koo, Toshiro Shinke, Yasuhiro Honda, Junya Shite, John F. LaDisa, Jr. Optical coherence tomography for patient-specific 3D artery reconstruction and evaluation of wall shear stress in a left circumflex coronary artery. Cardiovasc Eng Tech. 2011 Sept; 2(3): 212-7.

12. Timothy J. Gundert, Shawn C. Shadden, Andrew R. Williams, Bon-Kwon Koo, Jeffrey A. Feinstein, John F. LaDisa, Jr. A rapid and computationally inexpensive method for assessing patient-specific hemodynamic alterations introduced by commercially available and next-generation stents. Ann Biomed Eng. 2011 May; 39(5): 1423-37.

13. John F. LaDisa, Jr., Charles A. Taylor, Jeffrey A. Feinstein. Aortic coarctation: recent developments in experimental and computational methods to assess treatments for this simple condition. Prog Pediatr Cardiol 2010 Dec; 30(1): 45-9.

14. Raymond Q. Migrino, Mark R. Bowers, Leanne Harmann, Robert Prost, John F. LaDisa, Jr. Carotid plaque regression following 6-month statin therapy assessed by 3T MRI: comparison with ultrasound intima media thickness. J Cardiovasc Magn Reson. 2011 Aug 3;13(1):37.

15. Andrew R. Williams, Bon-Kwon Koo, Timothy J. Gundert, Peter J. Fitzgerald, John F. LaDisa, Jr. Local hemodynamic changes caused by main branch stent implantation and subsequent side branch balloon angioplasty in a representative coronary bifurcation. J Appl Physiol. 2010 Aug; 109(2): 532-40.

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16. James E. Moore Jr., Lucas H. Timmins, John F. LaDisa, Jr. Coronary artery bifurcation biomechanics and implications for interventional strategies. Catheter Cardiovasc Interv. 2010 Nov 15; 76(6):836-43.

17. John F. LaDisa, Jr., Mark R. Bowers, Leanne Harmann, Robert Prost, Anil Doppalapudi, Tayyab Mohyuddin, Osama Zaidat, Raymond Q. Migrino. Time-efficient patient-specific quantification of regional carotid artery fluid dynamics and spatial correlation with plaque burden following statin treatment. Medical Physics. 2010 Feb; 37(2): 784-92.

18. Hyun Jin Kim, Irene E. Vignon-Clementel, C. Alberto Figueroa, John F. LaDisa, Jr, Kenneth E. Jansen, Jeffrey A. Feinstein, Charles A. Taylor. On coupling a lumped parameter heart model and a three-dimensional finite element aorta model. Ann Biomed Eng. 2009 Nov; 37(11): 2153-69.

Prior to accepting faculty position at Marquette University: 19. John F. LaDisa, Jr., Lars E. Olson, Douglas A. Hettrick, David C. Warltier, Judy R.

Kersten, and Paul S. Pagel. Alterations in regional vascular geometry produced by theoretical stent implantation influence distributions of wall shear stress: analysis of a curved coronary artery using 3D computational fluid dynamics modeling. Biomed Eng Online. 2006 June 16; 5:40.

20. John F. LaDisa, Jr., Lars E. Olson, Douglas A. Hettrick, David C. Warltier, Judy R. Kersten, and Paul S. Pagel. Axial stent strut angle influences wall shear stress after stent implantation: analysis using 3D computational fluid dynamics models of stent foreshortening. Biomed Eng Online. 2005 Oct 26; 4(1):59.

21. John F. LaDisa, Jr., Lars E. Olson, Kristina M. Ropella, Robert C. Molthen, Steven T. Haworth, Judy R. Kersten, David C. Warltier, and Paul S. Pagel. Microfocal x-ray computed tomography post-processing operations for optimizing reconstruction volumes of stented arteries during 3D computational fluid dynamics modeling. Comput Methods Programs Biomed. 2005 Aug; 79(2):121-34.

22. John F. LaDisa, Jr., Lars E. Olson, Robert C. Molthen, Douglas A. Hettrick, Michael D. Hardel, Phillip F. Pratt, Judy R. Kersten, David C. Warltier, and Paul S. Pagel. Alterations in wall shear stress predict sites of neointimal hyperplasia after stent implantation in rabbit iliac arteries. Am J Physiol Heart Circ Physiol. 2005 May; 288(5):H2465-75.

23. John F. LaDisa, Jr., Lars E. Olson, Ismail Guler, Douglas A. Hettrick, Judy R. Kersten, David C. Warltier, and Paul S. Pagel. Circumferential vascular deformation after stent implantation alters wall shear stress evaluated using time-dependent 3D computational fluid dynamics models. J Appl Physiol. 2005; 98(3):947-57.

24. John F. LaDisa, Jr., Heidi T. Meier, Lars E. Olson, Judy R. Kersten, David C. Warltier and Paul S. Pagel. Antegrade iliac artery stent implantation for the temporal and spatial examination of stent-induced neointimal hyperplasia and alterations in regional fluid dynamics. J Pharmacol Toxicol Methods. 2005 Mar-Apr; 51(2):115-21.

25. John F. LaDisa Jr., John G. Krolikowski, Paul S. Pagel, David C. Warltier, and Judy R. Kersten. Cardioprotection by glucose-insulin-potassium: dependence on

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KATP channel opening and blood glucose concentration before ischemia. Am J Physiol Heart Circ Physiol. 2004 Aug; 287(2): H601-H607.

26. John F. LaDisa, Jr., Lars E. Olson, Ismail Guler, Douglas A. Hettrick, Said H. Audi, Judy R. Kersten, David C. Warltier, Paul S. Pagel. Stent design properties and deployment ratio influence indices of wall shear stress: a 3D computational fluid dynamics investigation within a normal artery. J Appl Physiol. 2004 July; 97(1):424-30.

27. Franz Kehl, John F. LaDisa Jr., Douglas A. Hettrick, Judy R. Kersten, David C. Warltier, Paul S. Pagel. Influence of isoflurane on left atrial function in dogs with pacing-induced cardiomyopathy: Evaluation with pressure-volume relationships. J of Cardiothorac and Vasc Anesth. 2003 Dec; 17(6):709-14.

28. Lynda M. Ludwig, Judy R. Kersten, Katsuya Tanaka, Weidong Gu, John F. LaDisa, Jr., David C. Warltier, Paul S. Pagel. Mechanisms of volatile anesthetic-induced myocardial protection. Curr Top in Pharmacol. 2003; 7(2): 195-207.

29. John F. LaDisa Jr., Ismail Guler, Lars E. Olson, Douglas A. Hettrick, Judy R. Kersten, David C. Warltier, Paul S. Pagel. Three-dimensional computational fluid dynamics modeling of alterations in coronary artery wall shear stress produced by stent implantation. Ann Biomed Eng. 2003 Aug; 31(8):972-980.

30. John F. LaDisa, Jr., Eric R. Gross, Dorothee Weihrauch, Douglas A. Hettrick, Lars E. Olson, Tobias Kress, Paul S. Pagel, David C. Warltier, and Judy R. Kersten. Reactive oxygen species modulate alterations in coronary wall shear stress and endothelial function during hyperglycemia. Am J Physiol Heart Circ Physiol. 2003 May; 284(5):H1552-H1559.

31. Franz Kehl, John G. Krolikowski, John F. LaDisa Jr., Judy R. Kersten, David C. Warltier, and Paul S. Pagel. Adenosine type 1 (A(1)) receptors mediate protection against myocardial infarction produced by chronic, intermittent ingestion of ethanol in dogs. Int J Cardiol. 2003 Apr; 88(2-3):175-82.

32. John F. LaDisa Jr., Douglas A. Hettrick, Lars E. Olson, Ismail Guler, Eric R. Gross, Tobias T. Kress, Judy R. Kersten, David C. Warltier, and Paul S. Pagel. Stent implantation alters coronary artery hemodynamics and wall shear stress during maximal vasodilation. J Appl Physiol. 2002 Dec; 93(6):1939-1946.

33. Katsuya Tanaka, Dorothee Weihrauch, Franz Kehl, Lynda M. Ludwig, John F. LaDisa Jr., Judy R. Kersten, Paul S. Pagel, and David C. Warltier. Mechanism of preconditioning by isoflurane in rabbits: a direct role for reactive oxygen species. Anesthesiology. 2002 Dec; 97(6):1485-1490.

34. Richard Rys, John F. LaDisa, Jr., John P. Tessmer, Judy R. Kersten, David C. Warltier, and Paul S. Pagel. An automated coronary artery occlusion device for stimulating collateral development in vivo. J Pharmacol Toxicol Methods. 2002; 48:111-18.

ABSTRACTS (students and trainees indicated in boldface)

Since accepting faculty position at Marquette University: 1. Joshua K. Hughey, Hiromasa Otake, Ken-ichi Hirata, John F. LaDisa, Jr. Impact of

stent platform on wall shear stress distributions after implantation: insights from

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computational fluid dynamics simulations using optical coherence tomography and coronary CT angiography. Submitted to the 7th World Congress of Biomechanics, Boston, 7/6-7/11/2014.

2. Joshua K. Hughey, Hiromasa Otake, Francesco Migliavacca, Mahdi Esmaily-Moghadam, Wei Wu, Claudio Chiastra, Nathan M. Wilson, Alison L. Marsden, John F. LaDisa, Jr. Towards optimizing mechanical stimuli around stents to reduce restenosis for challenging coronary artery lesions. Submitted to the 7th World Congress of Biomechanics, Boston, 7/6-7/11/2014.

3. Joshua K. Hughey, Michael Kamykowski, John F. LaDisa, Jr., Hiromasa Otake. Evaluation of wall shear stress in stented coronary arteries using optical coherence tomography and computational fluid dynamics. BMES Midwest Biomedical Engineering Career Conference, Chicago, IL, 4/19/13.

4. William M. Wang, David. J. Quam, Ronald K. Woods, John F. LaDisa, Jr. Toward the development of a stereoscopic visualization system with intuitive gesture-based control for biomedical and scientific datasets. BMES Midwest Biomedical Engineering Career Conference, Chicago, IL, 4/19/13.

5. Thomas A. Dienhart, Deepak Sharma, Robert W. Prost, John F. LaDisa, Jr. Initial analysis of local stent-induced blood flow alterations in a virtually-created arteriovenous fistula using computational fluid dynamics. BMES Midwest Biomedical Engineering Career Conference, Chicago, IL, 4/19/13.

6. Nathan M. Wilson, Ana K. Ortiz, Allison B. Johnson, Jeffrey A. Feinstein, John F. LaDisa, Jr., Alison L. Marsden. A public repository of image-based computational models and patient-specific blood flow simulation results. ASME Bioengineering Division, Summer Bioengineering Conference, Sunriver, OR, 6/26-29/13

7. Laura M. Ellwein, John F. LaDisa, Jr., Stacy Leibham, Sheila Schindler-Ivens, Margaret M. Samyn. Quantification of thoracic aorta blood flow by magnetic resonance imaging during supine cycling exercise of increasing intensity. 2013 annual meeting of the Society for Cardiovascular Magnetic Resonance (SCMR). To be held 1/31/13-2/3/13 in San Francisco.

8. DJ Quam, John F. LaDisa, Jr., Ronald K. Woods. Stereoscopic Visualization System with Intuitive Gesture-Based Control for Biomedical and Scientific Datasets. Accepted for poster - 2012 Engineering Frontiers conference. Stanford University and Lucile Packard Children's Hospital, 2012.

9. Laura M. Ellwein, Margaret M. Samyn, Michael Danduran, Sheila Schindler-Ivens, Stacy Leibham, John F. LaDisa, Jr. Translating near-infrared spectroscopy tissue oxygenation data for computational modeling of aortic and peripheral hemodynamics during exercise. Accepted for podium and poster presentation - 2012 Engineering Frontiers conference. Stanford University and Lucile Packard Children's Hospital, 2012.

10. Timothy J. Gundert, Alison L. Marsden, Weiguang Yang, John F. LaDisa, Jr. Identification of hemodynamically optimal stent configurations using computational fluid dynamics. Accepted for poster - FDA Computational Modeling for Cardiovascular Devices workshop in Rockville, MD, 2011.

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11. DJ Quam, Laura M. Ellwein, Raymond Q. Migrino, John F. LaDisa, Jr. Mobile virtual reality system for cardiovascular CFD analysis. Accepted for poster - Annals of Biomedical Engineering, Biomedical Engineering Society, Hartford, 2011.

12. Hongfeng Wang, Laura M. Ellwein, Judy R. Kersten, John F. LaDisa, Jr. Vascular changes in type 2 diabetes mellitus: application to restenosis after stenting. Accepted for poster - Annals of Biomedical Engineering, Biomedical Engineering Society, Austin, 2010.

13. Laura M. Ellwein, Hiromasa Otake, Bon-Kwon Koo, Toshiro Shinke, Yasuhiro Honda, Junya Shite, John F. LaDisa, Jr. Characterization of coronary artery pathologies and shear stress by optical coherence tomography. Accepted for podium presentation - Annals of Biomedical Engineering, Biomedical Engineering Society, Austin, 2010.

14. Timothy J. Gundert, John F. LaDisa, Jr. Evaluation of cerebral aneurysm stent performance in a subject-specific computational model. Accepted for poster - ASME Bioengineering Division, Summer Bioengineering Conference, Naples, 2010.

15. Sara Nomeland, Raymond Q. Migrino, David S. Marks, John F. LaDisa, Jr. Image-based quantification of 3-D morphology for bifurcations in the left coronary artery: application to stent design. Accepted for podium presentation - FDA Computational Modeling for Cardiovascular Devices workshop in Rockville, MD, 2010.

16. Andrew R. Williams, Jonathan A. Freeman, Raymond Q. Migrino, Bon-Kwon Koo, David S. Marks, W. Dennis Foley, John F. LaDisa, Jr. Computational simulations from CT angiography demonstrate altered hemodynamics in realistic stented coronary artery bifurcations. Annals of Biomedical Engineering, Biomedical Engineering Society, Pittsburgh, 2009.

17. David C. Wendell, Joseph Cava, Margaret Samyn, John F. LaDisa, Jr. Influence of aortic valve morphology on arch hemodynamics after successful aortic coarctation repair. Annals of Biomedical Engineering, Biomedical Engineering Society, Pittsburgh, 2009.

18. Timothy J. Gundert, Andrew R. Williams, John F. LaDisa, Jr. Rapid and computationally inexpensive quantification of hemodynamic alterations introduced by commercially-available and next-generation stents. FDA Computational Modeling for Cardiovascular Devices workshop in Rockville, MD, 2009.

19. Timothy J. Gundert, Paul Hayden, Raymond Q. Migrino, John F. LaDisa, Jr. Visualization of CFD results in a virtual reality environment. ASME Bioengineering Division, Summer Bioengineering Conference, Lake Tahoe, 2009.

20. John F. LaDisa, Jr., Joseph Cava, Ronak Dholakia, David Wendell, Mary Krolikowski, Margaret Samyn. Computational simulations from cardiac magnetic resonance imaging reveal altered hemodynamics in coarctation patients previously treated by patch aortoplasty Society of Cardiovascular Magnetic Resonance (SCMR) Annual Scientific Sessions. Orlando, 2009.

21. John F. LaDisa, Jr., Robert Prost, Leanne Harmann, Anil Doppalapudi, Tayyab Mohyuddin, Megan Bright, Raymond Q. Migrino. Relationship between regional

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wall shear stress and carotid plaque composition using 3T MRI and patient-specific computational fluid dynamics. Society of Cardiovascular Magnetic Resonance (SCMR) Annual Scientific Sessions. Orlando, 2009.

22. Ronak J. Dholakia, Paul M. Larsen, David C. Wendell and John F. LaDisa, Jr. An experimental and computational study of hemodynamics and arterial structure in aortic coarctation. Annals of Biomedical Engineering, Biomedical Engineering Society, St. Louis, 2008.

23. David Wendell, Paul S. Pagel and John F. LaDisa, Jr. Assessment of left ventricular function after treatment of aortic coarctation in an animal model. Annals of Biomedical Engineering, Biomedical Engineering Society, St. Louis, 2008.

24. Nathan M. Wilson, Raymond Q. Migrino, Leanne Harmann, Robert W. Prost, and John F. LaDisa, Jr. Modeling and realistic simulation of the carotid artery bifurcation using 3-D image segmentation implemented in a commercial software package for hemodynamic simulation (cvSimTM). ASME - Bioengineering Division, Summer Bioengineering Conference, Marco Island, 2008.

25. John F. LaDisa Jr., Robert Prost, Leanne Harmann, Tayyab Mohyuddin, Osama Zaidat, Jason Jurva, Anil Doppalapudi, Megan Bright and Raymond Q. Migrino. Patient-specific computational simulations of carotid artery hemodynamics complement clinical imaging data and correlate with plaque morphology after statin treatment. 5th International Caltech Biofluids Symposium and Workshop, Pasadena CA, March 28-30, 2008.

26. John F. LaDisa, Jr., Robert Prost, Leanne Harmann, Tayyab Mohyuddin, Osama Zaidat, Jason Jurva, Mahazarin Kaikobad, Megan Bright and Raymond Q. Migrino. Regional differences in carotid plaque morphology and shear stress using combined 3T MRI, ultrasound and patient-specific computational fluid dynamics and the effects of short-term statin treatment. SCAI Annual Scientific Sessions/ACC i2 Summit, Chicago, 2008.

27. John F. LaDisa, Jr., C. Alberto Figueroa, Irene E. Vignon-Clementel, Frandics P. Chan, Charles A. Taylor, Jeffrey A. Feinstein, Computational simulations demonstrate altered biomechanics in post-operative aortic coarctation patients. Annual Meeting of the American College of Cardiology, Chicago, 2008.

28. Lars E. Olson, John F. LaDisa, Jr., A model of shear-dependent neointimal growth of stented vessels. Annals of Biomedical Engineering, Biomedical Engineering Society, Los Angeles, 2007.

29. John F. LaDisa, Jr., C. Alberto Figueroa, Irene E. Vignon-Clementel, Frandics P. Chan, Jeffrey A. Feinstein, Charles A. Taylor. Use of CFD for the replication of clinical blood flow and pressure measurements and characterization of hemodynamics in the normal ascending and thoracic aorta. ASME Bioengineering Division, Summer Bioengineering Conference, Keystone, 2007.

30. Andrea S. Les, Christopher P. Cheng, Mary T. Draney Blomme, C. Alberto Figueroa, John F. LaDisa, Jinha M. Park, Robert J. Herfkens, Ronald L. Dalman, Charles A. Taylor. Hemodynamics in abdominal aortic aneurysms during rest and simulated exercise. ASME - Bioengineering Division, Summer Bioengineering Conference, Keystone, 2007.

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Prior to accepting faculty position at Marquette University: 31. John F. LaDisa, C. Alberto Figueroa, Irene E. Vignon-Clementel, Frandics P.

Chan, Jeffrey A. Feinstein, Charles A. Taylor. CFD estimation of hemodynamic alterations and indices of morbidity in aortic coarctation patients during moderate exercise. Invited Paper - 5th World Congress of Biomechanics, Munich, Aug 2006.

32. John F. LaDisa, Lars E. Olson, David C. Warltier, Paul S. Pagel. Computational fluid dynamics estimates of alterations in wall shear stress influencing neointimal hyperplasia after stent implantation. Invited Paper - 5th World Congress of Biomechanics, Munich, August 2006.

33. John F. LaDisa, Charles A. Taylor, Jeffrey A. Feinstein. Stent-induced alterations in compliance and hemodynamics in the aorta and head and neck arteries of patients with aortic coarctation. Society for Cardiac Angiography and Interventions, Chicago, 2006.

34. Alberto Figueroa, John F. LaDisa, Irene E. Vignon-Clementel, Kenneth E. Jansen, Thomas J.R. Hughes, Jeffrey A. Feinstein, Charles A. Taylor. A coupled-momentum method for fluid-structure interaction: application to aortic coarctation. 2nd International Conference on Computational Bioengineering, Lisbon, Portugal, September 14-16, 2005.

35. Irene E. Vignon-Clementel, C. Alberto Figueroa, John F. LaDisa, Jeffrey A. Feinstein, Kenneth E. Jansen, Charles A. Taylor. Impedance outflow boundary conditions for three-dimensional patient specific modeling of blood flow. ASME Bioengineering Division, Summer Bioengineering Conference, Vail, 2005.

36. John F. LaDisa, David C. Warltier, Lars E. Olson, Steve T. Haworth, Robert C. Molthen, Douglas A. Hettrick, Judy R. Kersten, Paul S. Pagel. Distributions of wall shear stress influence neointimal hyperplasia after stent implantation in vivo. Annals of Biomedical Engineering, Biomedical Engineering Society, Philadelphia, 2004.

37. John F. LaDisa, Lars E. Olson, Judy R. Kersten, David C. Warltier, Paul S. Pagel. Wall shear stress varies with stent properties and correlates with sites of neointimal hyperplasia. Annals of Biomedical Engineering, Biomedical Engineering Society, Nashville, 2003.

38. Franz Kehl, John F. LaDisa, Judy R. Kersten, David C. Warltier, Paul S. Pagel. Isoflurane adversely alters active and passive left atrial function and impairs left atrial-left ventricular coupling in dogs with pacing-induced cardiomyopathy as evaluated using pressure-volume relations. American Society of Anesthesiologists, San Francisco, 2003.

39. John F. LaDisa, David C. Warltier, Ismail Guler, Judy R. Kersten, Paul S. Pagel. Stent geometry and deployment ratio influence distributions of wall shear stress: three-dimensional numerical simulations exploiting properties of an implanted stent. ASME Bioengineering Division, Summer Bioengineering Conference, Key Biscayne, 2003.

40. John F. LaDisa, David C. Warltier, Lars E. Olson, Judy R. Kersten, Paul S. Pagel. Shear-modulated neointimal hyperplasia after stent implantation. FASEB Journal - Experimental Biology, San Diego, 2003.

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41. Weidong Gu, John F. LaDisa, Paul S. Pagel, David C. Warltier, Judy R. Kersten. Simvastatin restores the cardioprotective effect of ischemic preconditioning in the presence of hyperglycemia through a NO-mediated mechanism. American Society of Anesthesiologists, Orlando, 2002.

42. John F. LaDisa, John G. Krolikowski, Lynda M. Ludwig, Paul S. Pagel, David C. Warltier, Judy R. Kersten. Diabetes, Hyperglycemia, GIK and Cardioprotection: Do KATP Channels Play a Role? Journal of the American College of Cardiology, American College of Cardiology, Chicago, 2002.

43. John F. LaDisa, Lars E. Olson, Ismail Guler, Eric R. Gross, Douglas A. Hettrick, Judy R. Kersten, David C. Warltier, Paul S. Pagel. Coronary stent implantation alters wall shear stress during maximal vasodilation. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. v2 2002. p1228-1229. Houston, 2002.

44. John F. LaDisa, Lars E. Olson, Douglas A. Hettrick, Ismail Guler, Fernando DiCaprio, Paul S. Pagel, Judy R. Kersten, David C. Warltier. CFD modeling of hemodynamic changes caused by coronary stenting in vivo. Annals of Biomedical Engineering, Biomedical Engineering Society, Raleigh/Durham, 2001.

45. John F. LaDisa, Lars E. Olson, Fernando DiCaprio, Ismail Guler, David C. Warltier. In vivo measurement and fluid dynamics modeling of hemodynamic changes produced by coronary stenting. FASEB Journal - Experimental Biology, Orlando, 2001.

january 25, 2014 john f. la disa, jr., ph.d....

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