Editorials To Have and Have Not: Intrinsic Platelet Hyperreactivity? Marc Laine, Corinne Frere, and Laurent Bonello e008750. DOI: 10.1161/JAHA.118.008750.

Regulation of Kir2.1 Function Under Shear Stress and Cholesterol Loading Nhat-Tu Le and Jun-ichi Abe e008749. DOI: 10.1161/JAHA.118.008749.

Pediatric and Adolescent Pulmonary Hypertension: What Is the Risk of Undergoing Invasive Hemodynamic Testing? Anudeep Jassal, Omer Cavus, and Elisa A. Bradley e008625. DOI: 10.1161/JAHA.118.008625.

Original Research Arrhythmia and Electrophysiology

Prospective Randomized Evaluation of Implantable Cardioverter-Defibrillator Programming in Patients With a Left Ventricular Assist Device Travis D. Richardson, Leslie Hale, Christopher Arteaga, Meng Xu, Mary Keebler, Kelly Schlendorf, Matthew Danter, Ashish Shah, JoAnn Lindenfeld, and Christopher R. Ellis e007748. DOI: 10.1161/JAHA.117.007748.

Patient-Reported Outcomes in Relation to Continuously Monitored Rhythm Before and During 2 Years After Atrial Fibrillation Ablation Using a Disease-Specific and a Generic Instrument Anna Björkenheim, Axel Brandes, Anders Magnuson, Alexander Chemnitz, Nils Edvardsson, and Dritan Poçi e008362. DOI: 10.1161/JAHA.117.008362.

Physical Activity Measured by Implanted Devices Predicts Atrial Arrhythmias and Patient Outcome: Results of IMPLANTED (Italian Multicentre Observational Registry on Patients With Implantable Devices Remotely Monitored) Pietro Palmisano, Federico Guerra, Ernesto Ammendola, Matteo Ziacchi, Ennio Carmine Luigi Pisanò, Gabriele Dell’Era, Vittorio Aspromonte, Maria Zaccaria, Francesco Di Ubaldo, Alessandro Capucci, Gerardo Nigro, Eraldo Occhetta, Giampiero Maglia, Renato Pietro Ricci, Giuseppe Boriani, Michele Accogli, and on behalf of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC) e008146. DOI: 10.1161/JAHA.117.008146.

Cardiovascular Surgery Prognostic Value of Early Postoperative Troponin T in Patients Undergoing Coronary Artery Bypass Grafting Brigitta Gahl, Volkhard Göber, Ayodele Odutayo, Hendrik T. Tevaearai Stahel, Bruno R. da Costa, Stephan M. Jakob, G. Martin Fiedler, Olivia Chan, Thierry P. Carrel, and Peter Jüni e007743. DOI: 10.1161/JAHA.117.007743.

Safety of Perioperative Aprotinin Administration During Isolated Coronary Artery Bypass Graft Surgery: Insights From the ART (Arterial Revascularization Trial) Umberto Benedetto, Douglas G. Altman, Stephen Gerry, Alastair Gray, Belinda Lees, Gianni D. Angelini, Marcus Flather, and David P. Taggart on behalf of the ART (Arterial Revascularization Trial) Investigators e007570. DOI: 10.1161/JAHA.117.007570.

JAHA: Journal of the American Heart AssociationVolume 7, Issue 5

March 6, 2018

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Coronary Heart Disease High-Sensitivity Troponin I Levels and Coronary Artery Disease Severity, Progression, and Long-Term Outcomes Ayman Samman Tahhan, Pratik Sandesara, Salim S. Hayek, Muhammad Hammadah, Ayman Alkhoder, Heval M. Kelli, Matthew Topel, Wesley T. O'Neal, Nima Ghasemzadeh, Yi-An Ko, Mohamad Mazen Gafeer, Naser Abdelhadi, Fahad Choudhary, Keyur Patel, Agim Beshiri, Gillian Murtagh, Jonathan Kim, Peter Wilson, Leslee Shaw, Viola Vaccarino, Stephen E. Epstein, Laurence Sperling, and Arshed A. Quyyumi e007914. DOI: 10.1161/JAHA.117.007914.

Slow Gait Speed and Cardiac Rehabilitation Participation in Older Adults After Acute Myocardial Infarction Kelsey Flint, Kevin Kennedy, Suzanne V. Arnold, John A. Dodson, Sharon Cresci, and Karen P. Alexander e008296. DOI: 10.1161/JAHA.117.008296.

Adipose-Derived Exosomes Exert Proatherogenic Effects by Regulating Macrophage Foam Cell Formation and Polarization Zulong Xie, Xuedong Wang, Xinxin Liu, Huaan Du, Changbin Sun, Xin Shao, Jiangtian Tian, Xia Gu, Hailong Wang, Jinwei Tian, and Bo Yu e007442. DOI: 10.1161/JAHA.117.007442.

Effect of β-Blockers Beyond 3 Years After Acute Myocardial Infarction Jin Joo Park, Sun-Hwa Kim, Si-Hyuck Kang, Chang-Hwan Yoon, Young-Seok Cho, Tae-Jin Youn, In-Ho Chae, and Dong-Ju Choi e007567. DOI: 10.1161/JAHA.117.007567.

ADP Platelet Hyperreactivity Predicts Cardiovascular Disease in the FHS (Framingham Heart Study) Marja K. Puurunen, Shih-Jen Hwang, Martin G. Larson, Ramachandran S. Vasan, Christopher J. O'Donnell, Geoffrey Tofler, and Andrew D. Johnson e008522. DOI: 10.1161/JAHA.118.008522.

Hypercholesterolemia-Induced Loss of Flow-Induced Vasodilation and Lesion Formation in Apolipoprotein E–Deficient Mice Critically Depend on Inwardly Rectifying K+ Channels Ibra S. Fancher, Sang Joon Ahn, Crystal Adamos, Catherine Osborn, Myung-Jin Oh, Yun Fang, Catherine A. Reardon, Godfrey S. Getz, Shane A. Phillips, and Irena Levitan 007430. DOI: 10.1161/JAHA.117.007430.

Epidemiology Sex Differences in the Association Between Measures of General and Central Adiposity and the Risk of Myocardial Infarction: Results From the UK Biobank Sanne A. E. Peters, Sophie H. Bots, and Mark Woodward e008507. DOI: 10.1161/JAHA.117.008507.

Exercise Physiology Cardiac Rehabilitation Protects Against the Expansion of Abdominal Aortic Aneurysm Atsuko Nakayama, Hiroyuki Morita, Masatoshi Nagayama, Katsuyuki Hoshina, Yukari Uemura, Hitonobu Tomoike, and Issei Komuro e007959. DOI: 10.1161/JAHA.117.007959.

Genetics Genome-Wide Association Approach Identified Novel Genetic Predictors of Heart Rate Response to β-Blockers Mohamed H. Shahin, Daniela J. Conrado, Daniel Gonzalez, Yan Gong, Maximilian T. Lobmeyer, Amber L. Beitelshees, Eric Boerwinkle, John G. Gums, Arlene Chapman, Stephen T. Turner, Rhonda M. Cooper-DeHoff, and Julie A. Johnson e006463. DOI: 10.1161/JAHA.117.006463.

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Heart Failure Diastolic Blood Pressure and Adverse Outcomes in the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) Trial Pratik B. Sandesara, Wesley T. O'Neal, Heval M. Kelli, Matthew Topel, Ayman Samman-Tahhan, and Laurence S. Sperling e007475. DOI: 10.1161/JAHA.117.007475.

Predictive Value of Collagen Biomarkers for Heart Failure With and Without Preserved Ejection Fraction: MESA (Multi-Ethnic Study of Atherosclerosis) Daniel A. Duprez, Myron D. Gross, Jorge R. Kizer, Joachim H. Ix, William G. Hundley, and David R. Jacobs Jr e007885. DOI: 10.1161/JAHA.117.007885.

Clinical Outcomes in Patients With Nonobstructive, Labile, and Obstructive Hypertrophic Cardiomyopathy Dai-Yin Lu, Iraklis Pozios, Bereketeab Haileselassie, Ioannis Ventoulis, Hongyun Liu, Lars L. Sorensen, Marco Canepa, Susan Phillip, M. Roselle Abraham, and Theodore P. Abraham e006657. DOI: 10.1161/JAHA.117.006657.

Combined Angiotensin Receptor–Neprilysin Inhibitors Improve Cardiac and Vascular Function Via Increased NO Bioavailability in Heart Failure Rishi K. Trivedi, David J. Polhemus, Zhen Li, Daniel Yoo, Hiroshi Koiwaya, Amy Scarborough, Traci T. Goodchild, and David J. Lefer e008268. DOI: 10.1161/JAHA.117.008268.

Hypertension Twenty-Four-Hour Central Pulse Pressure for Cardiovascular Events Prediction in a Low-Cardiovascular-Risk Population: Results From the Bordeaux Cohort Antoine Cremer, Romain Boulestreau, Prune Gaillard, Marion Lainé, Georgios Papaioannou, and Philippe Gosse e008225. DOI: 10.1161/JAHA.117.008225.

Kidney Mass Reduction Leads to L -Arginine Metabolism-Dependent Blood Pressure Increase in Mice Samyuktha Muralidharan Pillai, Petra Seebeck, Ralph Fingerhut, Ji Huang, Xiu-Fen Ming, Zhihong Yang, and François Verrey e008025. DOI: 10.1161/JAHA.117.008025.

Network of Micro RNA s Mediate Translational Repression of Bone Morphogenetic Protein Receptor-2: Involvement in HIV -Associated Pulmonary Vascular Remodeling Mahendran Chinnappan, Aradhana Mohan, Stuti Agarwal, Pranjali Dalvi, and Navneet K. Dhillon e008472. DOI: 10.1161/JAHA.117.008472.

Left Ventricular Torsion Associated With Aortic Stiffness in Hypertension Jean-Barthelemy Gnakamene, Michel E. Safar, Bernard I. Levy, and Brigitte Escoubet e007427. DOI: 10.1161/JAHA.117.007427.

Kidney in Cardiovascular Disease High-Sensitivity Troponin T and C-Reactive Protein Have Different Prognostic Values in Hemo- and Peritoneal Dialysis Populations: A Cohort Study Titi Chen, Hicham C. Hassan, Pierre Qian, Monica Vu, and Angela Makris e007876. DOI: 10.1161/JAHA.117.007876.

Pediatric Cardiology Risk Factors for Major Early Adverse Events Related to Cardiac Catheterization in Children and Young Adults With Pulmonary Hypertension: An Analysis of Data From the IMPACT (Improving Adult and Congenital Treatment) Registry Michael L. O'Byrne, Kevin F. Kennedy, Joshua P. Kanter, John T. Berger, and Andrew C. Glatz e008142. DOI: 10.1161/JAHA.117.008142.

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Preventive Cardiology Circulating Concentrations of Redox Biomarkers Do Not Improve the Prediction of Adverse Cardiovascular Events in Patients With Type 2 Diabetes Mellitus Maxime Cournot, Elena Burillo, Pierre-Jean Saulnier, Cynthia Planesse, Elise Gand, Michaela Rehman, Stéphanie Ragot, Philippe Rondeau, Aurélie Catan, Marie-Paule Gonthier, Eva Feigerlova, Olivier Meilhac, and Samy Hadjadj e007397. DOI: 10.1161/JAHA.117.007397.

Temporal Trends of High-Intensity Statin Therapy Among Veterans Treated With Percutaneous Coronary Intervention Aref A. Bin Abdulhak, Mary Vaughan-Sarrzin, Peter Kaboli, Phillip A. Horwitz, Hilary Mosher, Gardar Sigurdsson, Nicholas E. Walker, Robert Wallace, and Jennifer G. Robinson e007370. DOI: 10.1161/JAHA.117.007370.

Stroke Hypoxia Inducible Factor 1α Plays a Key Role in Remote Ischemic Preconditioning Against Stroke by Modulating Inflammatory Responses in Rats Jian Yang, Cuiying Liu, Xiangnan Du, Menglei Liu, Xunming Ji, Huishan Du, and Heng Zhao e007589. DOI: 10.1161/JAHA.117.007589.

Micro RNA -210 Promotes Accumulation of Neural Precursor Cells Around Ischemic Foci After Cerebral Ischemia by Regulating the SOCS1–STAT3–VEGF-C Pathway Zhao-You Meng, Hua-Li Kang, Wei Duan, Jian Zheng, Qian-Ning Li, and Zhu-Juan Zhou e005052. DOI: 10.1161/JAHA.116.005052.

Downstream Microvascular Thrombosis in Cortical Venules Is an Early Response to Proximal Cerebral Arterial Occlusion Jean-Philippe Desilles, Varouna Syvannarath, Lucas Di Meglio, Célina Ducroux, William Boisseau, Liliane Louedec, Martine Jandrot-Perrus, Jean-Baptiste Michel, Mikael Mazighi, and Benoît Ho-Tin-Noé e007804. DOI: 10.1161/JAHA.117.007804.

Vascular Medicine Dipeptidyl Peptidase-4 Inhibition Potentiates Stimulated Growth Hormone Secretion and Vasodilation in Women Jessica R. Wilson, Nancy J. Brown, Hui Nian, Chang Yu, Martin Bidlingmaier, and Jessica K. Devin e008000. DOI: 10.1161/JAHA.117.008000.

Cardiopulmonary Exercise Testing in Patients Following Massive and Submassive Pulmonary Embolism Mazen S. Albaghdadi, David M. Dudzinski, Nicholas Giordano, Christopher Kabrhel, Brian Ghoshhajra, Michael R. Jaff, Ido Weinberg, and Aaron Baggish e006841. DOI: 10.1161/JAHA.117.006841.

Contemporary Review Sudden Unexplained Nocturnal Death Syndrome: The Hundred Years’ Enigma Jingjing Zheng, Da Zheng, Terry Su, and Jianding Cheng e007837. DOI: 10.1161/JAHA.117.007837.

Correction Myocardial Ischemia and Mobilization of Circulating Progenitor Cells e004230. DOI: 10.1161/JAHA.117.004230.

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7 (5)

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